Temperature-sensitive hydrogel loaded with Chinese herbal medicine vesicles for regulating immunity and preparation method of temperature-sensitive hydrogel

A thermoresponsive hydrogel combining PNIPAM with GelMA and quince leaf-derived EVLPs addresses mechanical and immune regulation deficiencies, effectively clearing ROS and modulating inflammation for improved tissue regeneration.

CN120305198APending Publication Date: 2025-07-15NANJING UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202510528246.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-25
Publication Date
2025-07-15

AI Technical Summary

Technical Problem

The prior art is difficult to effectively regulate inflammatory responses, oxidative stress and immune disorders during tissue regeneration, especially in terms of scavenging and immunomodulation of reactive oxygen species.

Method used

Poly(N-isopropylacrylamide) is introduced into methacrylylated gelatin, combined with extracellular vesicle-like particles from wolfberry leaves, to prepare a Chinese herbal vesicle temperature-sensitive hydrogel that regulates immunity, which has thermal responsiveness, mechanical properties, antioxidant and immune regulation functions.

Benefits of technology

It improves the local microenvironment, promotes tissue repair, removes reactive oxygen species, regulates immune response, achieves multiple biological activity effects, and promotes the high-value utilization of the wolfberry industry.

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Abstract

The invention relates to a Chinese herbal medicine vesicle-loaded temperature-sensitive hydrogel for regulating immunity and a preparation method thereof, and belongs to the technical field of biological medicines. The raw materials are wide in source, methacrylated gelatin (GelMA) has good biocompatibility, poly (N-isopropylacrylamide) (PNIPAM) and GelMA hydrogel are combined, meanwhile, lycium barbarum leaf source extracellular vesicle-like particles (LBL-EVLPs) are introduced, certain thermal responsiveness is achieved, the local immune microenvironment can be adjusted, and oxidative stress reaction can be effectively relieved. The temperature-sensitive hydrogel loaded with the Chinese herbal medicine vesicles provided by the invention has multiple effects of promoting tissue repair, removing reactive oxygen species (ROS), regulating immunity and the like, and has the advantages of simple preparation, low cost and the like.
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