Traditional Chinese medicine enema mixture composition for treating pelvic inflammation and application thereof

Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine enema mixture composition for treating pelvic inflammation and application thereof. The invention discloses a traditional Chinese medicine enema mixture composition for treating pelvic inflammation. The traditional Chinese medicine enema mixture composition is prepared from the following raw materials in parts by weight: hematoxylon, honeycomb, radix trichosanthis, spina gleditsiae, fructus liquidambaris, herba patriniae, vinegar-processed curcuma zedoary and cassia twig. The traditional Chinese medicine is prepared from 10-12 parts of sappan wood, 10-12 parts of honeycomb, 15-20 parts of radix trichosanthis, 12-15 parts of spina gleditsiae, 8-12 parts of fructus liquidambaris, 20-30 parts of herba patriniae, 10-12 parts of vinegar-processed rhizoma curcumae and 8-12 parts The traditional Chinese medicine enema mixture composition for treating pelvic inflammation provided by the invention has the effects of clearing away heat and toxic materials, dispersing blood stasis and dredging collaterals, and promoting qi circulation and relieving pain, and the medicine directly acts on a pelvic focus part.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease and its uses. Background Art

[0002] Pelvic inflammatory disease (PID) refers to a group of infectious diseases in the upper reproductive tract of women, mainly including endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis. Sequelae of chronic pelvic inflammatory disease (SPID) is the most common infectious disease in gynecology. It is a series of sequelae formed by the destruction of the female reproductive system and surrounding tissues, such as hyperplasia and adhesion, due to the failure to receive timely and correct treatment of pelvic inflammatory disease. It is also the main cause of chronic pelvic pain, infertility, and ectopic pregnancy. It is prone to recurrence when overworked, which has an adverse impact on the psychology, physiology, and quality of life of women. In particular, tubal infertility (TFI) caused by morphological changes such as tubal adhesions brings a heavy life and economic burden to them.

[0003] At present, Western medicine for the treatment of pelvic inflammatory disease mostly uses antibiotics, which has a significant effect on acute pelvic inflammatory disease. However, the treatment effect on tissue adhesions and blood circulation disorders caused by chronic inflammation is poor, and patients have low tolerance. Long-term use of antibiotics is prone to drug resistance, affecting the clinical treatment effect. The treatment methods of traditional Chinese medicine have shown good effects in the treatment of pelvic inflammatory disease, making up for the deficiencies of existing Western medicine treatment methods. Summary of the Invention

[0004] The purpose of the present invention is to solve the disadvantages existing in the prior art, and to provide a traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease and its uses.

[0005] In the first aspect, the present invention provides a traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease, and adopts the following technical scheme: A traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease, comprising sappanwood, nidus vespae, trichosanthin, gleditsia spine, clerodendron bungei, patrinia scabiosaefolia, zedoary turmeric vinegar, and cassia twig.

[0006] Preferably, it is prepared from the following raw materials in parts by weight: 10 - 12 parts of sappanwood, 10 - 12 parts of nidus vespae, 15 - 20 parts of trichosanthin, 12 - 15 parts of gleditsia spine, 8 - 12 parts of clerodendron bungei, 20 - 30 parts of patrinia scabiosaefolia, 10 - 12 parts of zedoary turmeric vinegar, and 8 - 12 parts of cassia twig.

[0007] Preferably, it is prepared from the following raw materials in parts by weight: 10 parts of Sappan Wood, 10 parts of Nidus Vespae, 20 parts of Trichosanthis Root, 12 parts of Gleditsiae Spina, 10 parts of Liquidambar Formosana Hance, 30 parts of Patrinia Scabiosaefolia, 10 parts of Rhizoma Curcumae Aromaticae Vinegar Processed, 10 parts of Ramulus Cinnamomi.

[0008] Preferably, it is prepared from the following raw materials in parts by weight: 12 parts of Sappan Wood, 12 parts of Nidus Vespae, 18 parts of Trichosanthis Root, 12 parts of Gleditsiae Spina, 10 parts of Liquidambar Formosana Hance, 25 parts of Patrinia Scabiosaefolia, 12 parts of Rhizoma Curcumae Aromaticae Vinegar Processed, 11 parts of Ramulus Cinnamomi.

[0009] Preferably, it is prepared from the following raw materials in parts by weight: 12 parts of Sappan Wood, 12 parts of Nidus Vespae, 15 parts of Trichosanthis Root, 12 parts of Gleditsiae Spina, 10 parts of Liquidambar Formosana Hance, 30 parts of Patrinia Scabiosaefolia, 11 parts of Rhizoma Curcumae Aromaticae Vinegar Processed, 10 parts of Ramulus Cinnamomi.

[0010] Preferably, the preparation method of the traditional Chinese medicine enema mixture composition comprises the following steps: Weigh each raw material component according to the parts by weight, put them into a casserole, add 1000 mL of water, stir evenly and soak for 1 hour, first boil over high heat and then change to low heat and decoct for 1 hour, filter out the medicinal liquid, let it stand and then filter out the precipitate, take 150 mL of the medicinal liquid and divide it into portions, then the traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease is obtained.

[0011] Among the above raw material components, the pharmacological effects of each traditional Chinese medicine raw material are as follows: Sappan Wood, with a neutral nature, promotes blood circulation to remove stasis, reduces swelling and relieves pain; Nidus Vespae, with a neutral nature, attacks toxins (sores and ulcers), kills insects, dispels wind and relieves pain; Trichosanthis Root, with a slightly cold nature, clears heat and purges fire, generates fluid to quench thirst, reduces swelling and discharges pus; Gleditsiae Spina, with a warm nature, reduces swelling and supports detoxification, kills insects; Liquidambar Formosana Hance, with a neutral nature, dispels wind and activates collaterals, promotes diuresis, and dredges menstruation. It is used for arthralgia, numbness and contracture, edema and distension, scanty lactation, amenorrhea; Patrinia Scabiosaefolia, with a cold nature, clears heat and detoxifies, eliminates carbuncles and discharges pus, removes stasis and relieves pain; Rhizoma Curcumae Aromaticae Vinegar Processed, with a warm nature, promotes qi circulation and breaks blood stasis, reduces accumulation and relieves pain Ramulus Cinnamomi, with a hot nature, induces sweating and relieves exterior syndrome, warms and dredges the meridian, warms and boosts yang qi; In this formula, Patrinia Scabiosaefolia and Trichosanthis Root are used as the monarch drugs to clear heat and detoxify, eliminate carbuncles and discharge pus, and remove stasis and relieve pain. Sappan Wood, Nidus Vespae, and Rhizoma Curcumae Aromaticae Vinegar Processed are used as the minister drugs to promote blood circulation to remove stasis and relieve pain. Gleditsiae Spina and Liquidambar Formosana Hance are used as the assistant drugs to reduce swelling and support detoxification and dredge collaterals. Ramulus Cinnamomi is used as the guiding drug to warm the meridian and boost yang, and together with Gleditsiae Spina, it restricts the cold nature of Patrinia Scabiosaefolia and Trichosanthis Root. The whole formula jointly exerts the functions of clearing heat and detoxifying, removing stasis and dredging collaterals, promoting qi circulation and relieving pain.

[0012] In the second aspect, the present invention provides a pharmaceutical preparation using the traditional Chinese medicine enema mixture composition as described in any one of the above as an active ingredient.

[0013] In a third aspect, the present invention provides an application of the traditional Chinese medicine enema mixture composition as described in any one of the above in the preparation of a medicament for treating pelvic inflammatory disease.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows: The traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease provided by the present invention has the effects of clearing heat and detoxifying, removing stasis and dredging collaterals, promoting qi circulation and relieving pain. The medicine directly acts on the pelvic lesion site to achieve the purpose of treating pelvic inflammatory diseases. Compared with simply using western medicine for treatment, it is more effective, has less toxic and side effects, better patient compliance, and is not prone to drug resistance. The traditional Chinese medicine enema composition for treating pelvic inflammatory diseases of the present invention has remarkable curative effects, less toxic and side effects, and good patient tolerance. Detailed implementation manners

[0015] To more clearly illustrate the present invention, the present invention will be further described below in conjunction with preferred embodiments. Those skilled in the art should understand that the specific content described below is illustrative rather than restrictive, and should not be used to limit the protection scope of the present invention. Embodiment

[0016] A traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease is prepared from the following raw materials in parts by weight: weigh 10 parts of sappanwood, 10 parts of nidus vespae, 20 parts of trichosanthes root, 12 parts of gleditsia spine, 10 parts of clerodendrum bungei, 30 parts of patrinia scabiosaefolia, 10 parts of zedoary turmeric vinegar, and 10 parts of cassia twig.

[0017] Weigh the above-mentioned raw materials in parts by weight one by one, and put the above-mentioned medicinal materials into a casserole, add 1000 ml of water, stir evenly and soak for 1 hour. First, bring to a boil over high heat and then change to low heat and boil for about 1 hour. Filter out the medicinal liquid, let it stand and then filter out the precipitate to obtain about 150 ml of enema mixture. Pour the medicinal liquid into a disposable enema bag.

[0018] Perform enema once a day, and control the temperature of the medicinal liquid at 40 ± 1 °C during enema. Precautions for enema: The enema time during the contraceptive period is from the end of menstruation to the next menstruation. The enema time during the pregnancy preparation period is from the end of menstruation to the ovulation day.

[0019] Empty the bladder and rectum before enema. The patient takes a lateral position, the lower limb pressed below is straightened, and the upper limb is naturally bent to fully expose the anus. The medical staff or family member inserts the enema device into the anus about 15 - 18 cm along the trend, turns on the enema control switch, drops the medicinal liquid into the intestine, which lasts for 5 - 8 minutes. After the enema is finished, take out the enema device, and try to keep the buttocks elevated and lie in bed for 30 minutes to allow the medicinal liquid to be fully absorbed. If there is no obvious discomfort, there is no need to go to the toilet. If there is an obvious urge to defecate, then go to the toilet to empty the medicinal liquid.

[0020] To further illustrate the efficacy of this traditional Chinese medicine enema mixture in the treatment of pelvic inflammatory diseases, 60 outpatients in the Department of Gynecology of Nantong Hospital of Traditional Chinese Medicine in Jiangsu Province were retrospectively analyzed for their clinical efficacy and adverse reactions.

[0021] I. Patient data All 60 cases were outpatients in the Department of Gynecology of Nantong Hospital of Traditional Chinese Medicine in Jiangsu Province, meeting the diagnostic criteria and randomly divided into 2 groups.

[0022] There were 30 cases in the treatment group, aged 25 - 40 years, with an average age of 30.00 ± 0.35 years; the disease course was 6 - 24 months, with an average of 10.0 ± 2.7 months.

[0023] There were 30 cases in the control group, aged 16 - 39 years, with an average age of 27.00 ± 0.41 years; the disease course was 5 - 25 months, with an average of 10.0 ± 3.1 months.

[0024] There were no statistically significant differences in the general data between the two groups (P > 0.05), and they were comparable.

[0025] II. Case selection Western medicine diagnostic criteria: Referring to the national higher medical textbook "Obstetrics and Gynecology": ① Having a history of inflammation in the endometrium, uterine body, adnexa, etc. with repeated attacks and secondary infertility; ② Chronic pelvic pain occurring from time to time, with lower abdominal distension, pain, and lumbosacral soreness, often aggravated after fatigue, sexual intercourse, and before and after menstruation, and an increase in vaginal discharge; ③ Gynecological examination: There may or may not be uterine tenderness, patchy thickening and tenderness in the adnexal area; or thickening of the uterosacral ligament, with or without tenderness; ④ B-ultrasound examination shows thickening of the fallopian tube, hydrosalpinx, tubo-ovarian mass, pelvic effusion, etc., or salpingography shows hydrosalpinx, patency with obstruction, or non-visualization of the fallopian tube.

[0026] Traditional Chinese medicine syndrome differentiation criteria: Based on the 3rd edition of "Clinical Gynecology of Traditional Chinese Medicine" and "Gynecology of Traditional Chinese Medicine", the relevant syndrome diagnosis criteria were formulated: Syndrome of dampness stagnation and blood stasis: Repeated attacks of lower abdominal pain, dull pain accompanied by lumbosacral soreness, occurring when tired, heavy menstrual bleeding with blood clots or accompanied by prolonged menstrual period, profuse leucorrhea, yellow in color, sometimes with an abnormal smell, pale and dull tongue or with stasis spots, white or greasy tongue coating, and stringy and unsmooth pulse.

[0027] Inclusion criteria: ① Meeting the diagnostic criteria for sequelae of pelvic inflammatory diseases, and being differentiated as the syndrome of dampness stagnation and blood stasis in traditional Chinese medicine; ② Aged 24 - 41 years; ③ Disease course of more than 12 months; ④ Informed consent from the patient; This study was approved by the Medical Ethics Committee of Nantong Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, with the ethics number: Tongzhongyuan

[2020] No. 007.

[0028] Exclusion criteria: ① Not meeting the diagnostic criteria for sequelae of pelvic inflammatory disease; ② Acute exacerbation stage of pelvic inflammatory disease; ③ Course of disease less than 12 months; ④ Having severe heart, liver, kidney, hematopoietic system diseases or malignant tumors, or mental disorders; ⑤ Those in the attack stage of anorectal diseases such as hemorrhoids and anal fistulas; ⑥ Those who did not take medicine as prescribed or whose data were incomplete and the curative effect could not be determined; ⑦ Having used hormonal drugs such as contraceptives and glucocorticoids in the past 1 month; ⑧ Those with allergic constitution or allergic to the drugs used in this study; ⑨ Those who are currently participating in other clinical drug trials.

[0029] Criteria for terminating clinical observation: ① Poor compliance and inability to adhere to treatment; ② Those who experience serious adverse events during clinical observation; ③ Those who develop complications and are not suitable for continued treatment; ④ Those who withdraw from clinical observation voluntarily.

[0030] III. Treatment plan Medication plan: Treatment group: Starting from 3 - 7 days after menstruation stops, continuously administer the enema mixture for pelvic inflammatory disease in this example rectally for 14 days, and continuously treat for 3 menstrual cycles; Control group: Starting from 3 - 7 days after menstruation stops, continuously administer Guizhi Fuling Pills (formula) rectally for 14 days, and continuously treat for 3 menstrual cycles.

[0031] Rectal administration method: The patient takes a lateral position, the lower limb pressed below is straightened, the upper limb is naturally bent, the anus is exposed, the enema device is inserted into the anus about 15 - 18 cm along the trend, the control switch is turned on, the medicinal liquid is dropped into the intestine, which lasts for 5 - 8 minutes. After the enema is completed, the enema device is taken out, and the buttocks are lifted high and the patient lies in bed for 30 minutes.

[0032] Volume of rectal administration liquid: 150 ml.

[0033] Temperature of rectal administration liquid: 40 °C.

[0034] Preparation of rectal administration liquid: In the treatment group, the traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease in this example is selected; in the control group of Guizhi Fuling Capsules (produced by Jiangsu Kanion Pharmaceutical Co., Ltd.), the drugs in 12 capsules are dissolved in tap water that has been boiled and then cooled to 80 °C; then it is cooled to 40 °C for standby.

[0035] Guizhi Fuling Capsules (formula): Cinnamon twig, peach kernel, moutan bark, white peony root, poria cocos.

[0036] Course of treatment: Continuous treatment for 3 menstrual cycles is taken as 1 course of treatment. After 1 course of treatment, the medicine is stopped, the monitoring indicators are observed and the curative effect is evaluated. Telephone follow - up is conducted 6 months and 12 months after stopping the medicine to evaluate the recurrence rate and long - term curative effect.

[0037] IV. Observation indicators Clinical efficacy: It is divided into cured, markedly effective, effective, and ineffective. The total effective rate = (cured + markedly effective + effective) / total number of cases × 100%.

[0038] Symptom, sign score, and disease severity: The grading score was carried out with reference to the "Guiding Principles for Clinical Research of New Chinese Medicines"

[126] .

[0039] Main symptoms: According to the severity of lower abdominal pain, lumbosacral distending pain, vaginal discharge volume, vaginal discharge color, and vaginal discharge odor, it is divided into 0 points, 2 points, 4 points, and 6 points.

[0040] Secondary symptoms: According to the conditions of fatigue, low-grade fever, irregular menstruation, dysmenorrhea, chest and hypochondrium and breast distending pain, cold limbs, urine, stool, etc., the score is 0 points, 1 point, 2 points, and 3 points.

[0041] Sign scoring criteria: The severity of one or both fallopian tubes showing cord-like thickening or (and) patchy thickening and tenderness on one side of the uterus, and tenderness of bilateral adnexal masses is divided into 0 points, 2 points, and 4 points. According to the severity of thickening and tenderness of one or both uterosacral ligaments, it is divided into 0 points, 1 point, and 2 points.

[0042] Disease severity scoring criteria: The cumulative score of the above three items is more than 35 points for severe, 25 - 34 points for moderate, and less than 25 points for mild.

[0043] Efficacy criteria: ① Cured: Clinical symptoms disappear, there is no tenderness in the uterine body and adnexa during gynecological examination, the cervix has no lift pain, the fallopian tube angiography shows that the fallopian tube is unobstructed, the integral is reduced by more than 95% compared with before treatment, and there is no recurrence after half a year of follow-up; ② Markedly effective: Clinical symptoms disappear, there is no tenderness in the uterine body and adnexa during gynecological examination, the cervix has no lift pain, the fallopian tube angiography indicates that it is unobstructed but not smooth enough, the integral is reduced by 70% - 95% compared with before treatment, and it relapses after half a year; ③ Effective: Clinical symptoms and gynecological examination are both alleviated compared with before treatment, but there are relapses from time to time, the fallopian tube angiography indicates that it is unobstructed but not smooth enough, the integral is reduced by 30% - 70% compared with before treatment; ④ Ineffective: There is no change in clinical symptoms and gynecological examination, there is no change in fallopian tube angiography, and the integral change is not obvious, less than 30%.

[0044] V. Comparison of the efficacy between the treatment group and the control group Table 1 Comparison of the efficacy between the two groups As can be seen from Table 1, the effective rate of the treatment group is better than that of the control group, (P < 0.05); the pregnancy rate of the treatment group is better than that of the control group, (P < 0.05).

[0045] Comparison of the symptom, sign (disease severity) integral between the two groups of patients before and after treatment Table 2 Comparison of the symptom, sign integral (disease severity) between the two groups of patients before and after treatment As can be seen from Table 2, within each group, the improvement of symptoms, signs (disease severity) after treatment is better than that before treatment, (P < 0.01); Comparisons between groups showed that the treatment group was superior to the control group (P < 0.01).

[0046] In the field of traditional Chinese medicine (TCM) gynecology, most scholars believe that the pathogenesis characteristics of SPID vary among different patients, with multiple syndrome types, mainly described as damp-heat stasis syndrome, qi stagnation and blood stasis syndrome, cold-damp stagnation syndrome, qi deficiency and blood stasis syndrome, and kidney deficiency and blood stasis syndrome, and corresponding syndrome differentiation and prescription are carried out. The treatment of SPID by rectal administration of traditional Chinese medicine is an extension of external treatment methods in TCM. It has been used in modern TCM gynecology for more than forty years and achieved good results. The female pelvic cavity has rich blood circulation, and the pelvic cavity is adjacent to the rectal mucosa. The rectal administration of traditional Chinese medicine is quickly absorbed and avoids the first-pass effect of the liver of oral drugs, enabling the drug to directly act on the pelvic lesion site, thus improving the therapeutic effect of the drug.

[0047] Etiology and pathogenesis of pelvic inflammatory disease: Dampness is lingering, and over time, it turns into heat and toxin, forming stasis and blocking collaterals, resulting in difficult-to-heal abdominal pain. Therefore, the treatment should target the dampness stagnation transforming into heat, stasis and blocked collaterals, and the method is to clear heat and detoxify, supplemented by warming the meridian, promoting blood circulation and dredging collaterals.

[0048] Clinical typical cases: Case 1: Yan, 27 years old, visited the doctor due to infertility after 2 years of marriage. Initial diagnosis time: May 11, 2019. Last menstrual period: April 22, 2019. The patient usually had regular menstruation, 5 / 30 days, without dysmenorrhea. Usually, there was leucorrhea with a slight odor, which was not taken seriously. There was no other special medical history. Before visiting the doctor, the patient had previously undergone in vitro fertilization technology at the Ji'ai Center of Obstetrics and Gynecology Hospital Affiliated to Fudan University in Shanghai. After various examinations, it was found that one fallopian tube was unobstructed and the other had hydrosalpinx. She was required to treat the fallopian tube inflammation before proceeding with in vitro fertilization technology, so she came to our clinic. The rectal administration agent of Example 1 of the present invention was used for 3 cycles. On January 5, 2020, she reported a missed period of 35 days. The HCG was 3720 miU / ml. Follow-up visit: In October 2020, she was informed that she had a cesarean section of a 3.8 kg male infant at 39 weeks + 5 of pregnancy, and both the mother and the baby were safe.

[0049] Case 2: Sun, female, 43 years old, visited the doctor due to recurrent lower abdominal pain for 3 years, which occurred or worsened when tired. Initial diagnosis: March 9, 2021. Based on clinical symptoms, gynecological examination, and color Doppler ultrasound, pelvic inflammatory disease was diagnosed. Subsequently, the rectal administration of Example 1 of the present invention was used. The patient was instructed to retain the rectal administration for 30 minutes after menstruation ended, for 14 consecutive days, for a total of 3 menstrual cycles. Follow-up and review were carried out, and the patient was instructed to avoid excessive fatigue. If abdominal pain occurred or worsened again, she should follow up. The patient did not experience abdominal pain, and the laboratory test indicators were normal. After a 3-month follow-up visit, the patient did not relapse.

[0050] Case 3: Kong XX, female, 34 years old. The patient was hospitalized for the treatment of acute pelvic inflammatory disease 3 years ago and was discharged after the abdominal pain disappeared. Subsequently, she suffered from fatigue attacks many times. Two weeks ago, after working continuously for 18 hours, she had dull pain in the lower abdomen. She took levofloxacin by herself, but the abdominal pain did not disappear, so she came to the doctor. Subsequently, rectal administration was performed according to Example 1 of the present invention. The patient was instructed to retain the rectal administration for 30 minutes every time after menstruation ended, for 14 consecutive days, and was followed up and reexamined for a total of 3 menstrual cycles. The patient was also instructed to avoid excessive fatigue. In case of recurrence or aggravation of abdominal pain, she should follow up. The patient did not have abdominal pain, and the laboratory test indicators were normal. After 6 months of follow-up, the patient did not relapse. Example

[0051] A traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease is prepared from the following raw materials in parts by weight: Weigh 12 parts of sappanwood, 12 parts of nidus vespae, 18 parts of trichosanthes root, 12 parts of gleditsia spine, 10 parts of clerodendrum bungei, 25 parts of patrinia scabiosaefolia, 12 parts of zedoary turmeric processed with vinegar, and 11 parts of cassia twig.

[0052] The clinical efficacy of treating pelvic inflammatory diseases with the traditional Chinese medicine enema mixture of this example is as follows: 30 people were clinically treated, 15 were cured, 8 were markedly effective, 4 were effective, 3 were ineffective, and the total effective rate was 90%. Example

[0053] A traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease is prepared from the following raw materials in parts by weight: Weigh 12 parts of sappanwood, 12 parts of nidus vespae, 15 parts of trichosanthes root, 12 parts of gleditsia spine, 10 parts of clerodendrum bungei, 30 parts of patrinia scabiosaefolia, 11 parts of zedoary turmeric processed with vinegar, and 10 parts of cassia twig.

[0054] The clinical efficacy of treating pelvic inflammatory diseases with the traditional Chinese medicine enema mixture of this example is as follows: 30 people were clinically treated, 16 were cured, 9 were markedly effective, 3 were effective, 2 were ineffective, and the total effective rate was 93.33%.

[0055] As mentioned above, it is only the preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and all should be covered within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease, characterized in that, It includes Sappan Wood, Nidus Vespae, Trichosanthis Root, Spina Gleditsiae, Fructus Liquidambaris, Patrinia Scabiosaefolia, Rhizoma Curcumae with Vinegar Processed, and Ramulus Cinnamomi.

2. The traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease according to claim 1, wherein It is prepared from the following raw materials in parts by weight: 10 - 12 parts of Sappan Wood, 10 - 12 parts of Nidus Vespae, 15 - 20 parts of Trichosanthis Root, 12 - 15 parts of Spina Gleditsiae, 8 - 12 parts of Fructus Liquidambaris, 20 - 30 parts of Patrinia Scabiosaefolia, 10 - 12 parts of Rhizoma Curcumae with Vinegar Processed, and 8 - 12 parts of Ramulus Cinnamomi.

3. The traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease according to claim 2, wherein, It is prepared from the following raw materials in parts by weight: 10 parts of Sappan Wood, 10 parts of Nidus Vespae, 20 parts of Trichosanthis Root, 12 parts of Spina Gleditsiae, 10 parts of Fructus Liquidambaris, 30 parts of Patrinia Scabiosaefolia, 10 parts of Rhizoma Curcumae with Vinegar Processed, and 10 parts of Ramulus Cinnamomi.

4. The traditional Chinese medicine retention enema mixture composition for treating pelvic inflammatory disease according to claim 2, wherein, It is prepared from the following raw materials in parts by weight: 12 parts of Sappan Wood, 12 parts of Nidus Vespae, 18 parts of Trichosanthis Root, 12 parts of Spina Gleditsiae, 10 parts of Fructus Liquidambaris, 25 parts of Patrinia Scabiosaefolia, 12 parts of Rhizoma Curcumae with Vinegar Processed, and 11 parts of Ramulus Cinnamomi.

5. The traditional Chinese medicine retention enema mixture composition for treating pelvic inflammatory disease according to claim 2, characterized in that It is prepared from the following raw materials in parts by weight: 12 parts of Sappan Wood, 12 parts of Nidus Vespae, 15 parts of Trichosanthis Root, 12 parts of Spina Gleditsiae, 10 parts of Fructus Liquidambaris, 30 parts of Patrinia Scabiosaefolia, 11 parts of Rhizoma Curcumae with Vinegar Processed, and 10 parts of Ramulus Cinnamomi.

6. The traditional Chinese medicine retention enema mixture composition for treating pelvic inflammatory disease according to any one of claims 2, wherein, The preparation method of the traditional Chinese medicine enema mixture composition comprises the following steps: Weigh each raw material component according to the parts by weight, put them into a casserole, add 1000 mL of water, stir evenly and soak for 1 hour, first boil over high heat and then change to low heat and decoct for 1 hour, filter out the medicinal liquid, let it stand and then filter out the precipitate, take 150 mL of the medicinal liquid and divide it into portions, thus obtaining the traditional Chinese medicine enema mixture composition for treating pelvic inflammatory disease.

7. A pharmaceutical preparation with the traditional Chinese medicine enema mixture composition as defined in any one of claims 1 - 6 as an active ingredient.

8. Use of the traditional Chinese medicine enema mixture composition as defined in any one of claims 1 - 6 in the preparation of a medicament for treating pelvic inflammatory disease.