Real-time image monitoring and regulating system and device in tendon trauma treatment
A real-time imaging system with differential nanosecond pulse electric field stimulation addresses the challenge of balancing tendon healing and adhesion prevention, enhancing treatment precision and effectiveness.
Patent Information
- Application Number
- CN202510416203.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-03
- Publication Date
- 2025-07-15
AI Technical Summary
In the existing treatment methods for tendon trauma, the differential stimulation of the pulsed electric field is not intelligent and accurate enough, making it difficult to achieve the best balance between promoting regeneration at the anastomosis and preventing peritoneal adhesion, resulting in poor tendon mechanical performance or high refraction rate.
It provides a real-time image monitoring and regulation system and device in tendon trauma treatment. Through real-time image acquisition, analysis and regulation module, differential stimulation of nanosecond pulse electric field is realized, and the application of low-high-intensity nanosecond pulse electric field is accurately controlled according to the dynamic time evolution curve of the tendon healing process.
It improves the intelligence and accuracy of pulsed electric field stimulation in tendon trauma treatment, promotes regeneration at the anastomosis and inhibits peritoneal adhesions, improves the mechanical properties of the tendon and reduces the refraction rate.
Smart Images
Figure CN120305560A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of sports trauma repair and rehabilitation physical therapy devices, and particularly to a real-time imaging monitoring and regulation system and device in tendon trauma treatment. Background Art
[0002] During surgical treatment of tendon injuries or ruptures caused by sports or trauma, it is easy to form scars with weak anti-tensile strength at the anastomosis, resulting in poor mechanical properties of the tendon, thus increasing the re-rupture rate, or forming excessive scars around the anastomosis, leading to adhesion of the peritendinous tissue and affecting limb motor function. The two common complications of re-rupture at the tendon anastomosis and peritendinous adhesion after tendon anastomosis are the main factors causing poor prognosis of tendon treatment. For functional tendon trauma repair and rehabilitation treatment, it is necessary to make the tendon healing at the tendon stump have sufficient strength and prevent adhesion in the peritendinous tissue. However, clinically, these two often restrict each other and it is difficult to achieve the best balance point. Existing tendon trauma repair and rehabilitation treatment methods either only focus on how to accelerate tendon healing, but it is easy to cause hyperplasia and adhesion of scar tissue around the anastomosis while promoting regeneration at the anastomosis, affecting limb motor function; or only focus on inhibiting the formation of scars around the anastomosis, but it causes poor healing at the anastomosis, resulting in poor mechanical properties of the tendon and a high re-rupture rate; and it cannot effectively solve the contradiction between regeneration repair at the anastomosis and prevention of peritendinous adhesion.
[0003] Research has found that nanosecond pulsed electric field stimulation has a dose-dependent bidirectional regulation effect on the proliferation and differentiation of osteoblasts and myoblasts, that is, low-intensity nanosecond pulsed electric field stimulation has a promoting effect on the proliferation and differentiation of osteoblasts and myoblasts, while high-intensity nanosecond pulsed electric field stimulation has an inhibitory or even killing and ablation effect on cell proliferation and differentiation, and it is expected to better solve the contradiction between promoting regeneration and preventing peritendinous adhesion at the anastomosis, and has important application value in the field of functional tendon trauma repair and rehabilitation treatment. However, in existing tendon trauma treatment methods, the differential stimulation of pulsed electric fields is not intelligent and precise enough. Summary of the Invention
[0004] In view of this, this application provides a real-time imaging monitoring and regulation system and device in tendon trauma treatment, which improves the intelligence and precision of differential stimulation of pulsed electric fields through real-time imaging monitoring, evaluation and regulation during the process of tendon trauma repair and rehabilitation treatment.
[0005] The first aspect of this application provides a real-time imaging monitoring and regulation system in tendon trauma treatment. The system includes a pulsed electric field energy generation module, a treatment process image acquisition module, an image analysis module and a regulation module; The pulsed electric field energy generation module is used to output a nanosecond pulsed electric field according to treatment parameters to stimulate and treat the target tendon; The treatment process image acquisition module is used to acquire real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process; The image analysis module determines the radiopharmaceutical concentration of the target tendon through the real-time treatment images, and performs quantitative analysis on the radiopharmaceutical concentration to obtain a dynamic time evolution curve reflecting the repair and healing process of the target tendon; The regulation module is used to perform differential stimulation regulation on the anastomosis and peritendinous area of the target tendon according to the dynamic time evolution curve.
[0006] Optionally, the differential stimulation regulation of the anastomosis and peritendinous area of the target tendon according to the dynamic time evolution curve includes: Determine the healing state of the target tendon through the dynamic time evolution curve, and the healing state includes the inflammatory phase, the proliferation phase, and the scar phase; When it is determined that the target tendon is in the late inflammatory stage and the early proliferation stage, move the matrix electrode to the anastomosis of the target tendon, turn on the low-intensity nanosecond pulsed electric field for treatment, and turn off the low-intensity nanosecond pulsed electric field until it is determined that the target tendon is in the late proliferation stage; When it is determined that the target tendon is in the late proliferation stage and the early scar stage, move the matrix electrode to the peritendinous area of the target tendon, turn on the high-intensity nanosecond pulsed electric field for ablation inhibition, and turn off the high-intensity nanosecond pulsed electric field until it is determined that the target tendon is in the late scar stage.
[0007] Optionally, the real-time treatment image is a PET / CT image.
[0008] Optionally, the acquisition of the real-time treatment image of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process includes: Determine a radioactive probe that specifically targets key biomarkers during tendon repair, and arrange the radioactive probe in the anastomosis and peritendinous area of the target tendon; Capture the distribution and metabolism of the radioactive probe in the target tendon through a PET detector to obtain a PET image; Scan the target tendon with a CT scanner to obtain a CT image.
[0009] Optionally, the system further includes an electric field energy monitoring module; The electric field energy monitoring module is used to monitor the nanosecond pulsed electric field output by the pulsed electric field energy generation module according to a preset threshold interval; When it is determined that the electric field parameters of the nanosecond pulsed electric field are not within the threshold range, the energy output of the pulsed electric field energy generation module is stopped, where the electric field parameters include voltage, pulse width, and frequency.
[0010] Optionally, the system further includes a current detection module; The current detection module is configured to detect the current of the matrix electrode through a current sensor when the pulsed electric field energy generation module outputs a nanosecond pulsed electric field, and issue an alarm when it is determined that the current of the matrix electrode exceeds the safety threshold.
[0011] A second aspect of the present application provides a real-time image monitoring and regulation device in tendon trauma treatment, and the device includes: A pulsed electric field energy generation unit, configured to output a nanosecond pulsed electric field according to treatment parameters to stimulate and treat a target tendon; A treatment process image acquisition unit, configured to acquire real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process; An image analysis unit, configured to determine the radiopharmaceutical concentration of the target tendon through the real-time treatment images, and perform quantitative analysis on the radiopharmaceutical concentration to obtain a dynamic time evolution curve reflecting the repair and healing process of the target tendon; A regulation unit, configured to perform differential stimulation regulation on the anastomosis and peritendinous regions of the target tendon according to the dynamic time evolution curve.
[0012] Optionally, the differential stimulation regulation of the anastomosis and peritendinous regions of the target tendon according to the dynamic time evolution curve in the regulation unit includes: Determining the healing state of the target tendon through the dynamic time evolution curve, where the healing state includes an inflammatory phase, a proliferative phase, and a scar phase; When it is determined that the target tendon is at the end of the inflammatory phase and the beginning of the proliferative phase, move the matrix electrode to the anastomosis of the target tendon, turn on a low-intensity nanosecond pulsed electric field for treatment, and turn off the low-intensity nanosecond pulsed electric field until it is determined that the target tendon is at the end of the proliferative phase; When it is determined that the target tendon is at the end of the proliferative phase and the beginning of the scar phase, move the matrix electrode to the peritendinous region of the target tendon, turn on a high-intensity nanosecond pulsed electric field for ablation inhibition, and turn off the high-intensity nanosecond pulsed electric field until it is determined that the target tendon is at the end of the scar phase.
[0013] Optionally, the real-time treatment images in the treatment process image acquisition unit are PET / CT images; the acquisition of the real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process includes: Determine a radioactive probe that specifically targets key biomarkers during tendon repair, and arrange the radioactive probe in the anastomotic site and peritendinous region of the target tendon; Capture the distribution and metabolism of the radioactive probe in the target tendon by a PET detector to obtain a PET image; Scan the target tendon by a CT scanner to obtain a CT image.
[0014] Optionally, the device further includes: An electric field energy monitoring unit for monitoring the nanosecond pulsed electric field output by the pulsed electric field energy generation module according to a preset threshold range; When it is determined that the electric field parameters of the nanosecond pulsed electric field are not within the threshold range, stop the energy output of the pulsed electric field energy generation module, where the electric field parameters include voltage, pulse width, and frequency; A current detection unit for detecting the current between the matrix electrodes by a current sensor when the pulsed electric field energy generation module outputs a nanosecond pulsed electric field, and giving an alarm when it is determined that the current of the matrix electrodes exceeds a safety threshold.
[0015] In the embodiments provided in the present application, the system obtains real-time images during the pulsed electric field tendon functional trauma repair and rehabilitation treatment through an image acquisition module, and then determines the dynamic time evolution curve of the tendon repair and healing process through an image analysis module according to the radiopharmaceutical concentration. Finally, high- and low-intensity nanosecond pulsed electric fields are applied to the anastomotic site and peritendinous region of the target tendon with different healing states according to the curve, so as to achieve differential stimulation regulation. This improves the intelligence and accuracy of differential stimulation treatment of tendons by nanosecond pulsed electric fields. Description of the Drawings
[0016] Figure 1 It is a system module diagram provided by an embodiment of the present application; Figure 2 It is a hardware module structure diagram provided by an embodiment of the present application; Figure 3 It is a device structure diagram provided by an embodiment of the present application; Figure 4 It is an internal structure schematic diagram of a computer device provided by an embodiment of the present application. Detailed Embodiments
[0017] Exemplary embodiments will be described in detail herein, and examples thereof are shown in the accompanying drawings. When the following description refers to the accompanying drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. On the contrary, they are merely examples of devices and methods consistent with some aspects of the present application as detailed in the appended claims.
[0018] The terms used in this application are for the purpose of describing particular embodiments only and are not intended to limit the present application. The singular forms "a", "the", and "said" used in this application and the appended claims are also intended to include the plural forms unless the context clearly dictates otherwise. It should also be understood that the term "and / or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
[0019] It should be understood that although the terms first, second, third, etc. may be used in this application to describe various information, such information should not be limited to these terms. These terms are only used to distinguish information of the same type from each other. For example, without departing from the scope of the present application, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Depending on the context, the word "if" as used herein may be interpreted as "when" or "upon" or "in response to determining".
[0020] The present application provides a real-time imaging monitoring and regulation system in tendon trauma treatment to improve the intelligence and accuracy of differential stimulation treatment of tendons by nanosecond pulsed electric fields.
[0021] The technical solutions of the present application will be described in detail below with specific embodiments. These several specific embodiments below can be combined with each other, and the same or similar concepts or processes may not be repeated in some embodiments.
[0022] As Figure 1 shown, it is a module diagram of a pulsed electric field adaptive stimulation regulation system for tendon trauma provided by the present application. The functions and effects of each module will be described below.
[0023] 1. Pulsed electric field energy generation module. This module is used to output a nanosecond pulsed electric field to stimulate the target tendon according to the treatment parameters.
[0024] In this module, there are usually a high-voltage power supply, a pulse generator, and electrodes. The high-voltage power supply provides high voltage for the pulse generator, which generates a nanosecond-level pulsed electric field. Then, the pulsed electric field energy is transferred to the target tendon through the electrodes. The electrodes can be surface electrodes or needle electrodes. The surface electrodes are used for non-invasive treatment by placing them on the skin surface, while the needle electrodes are directly inserted into the target tendon for invasive treatment.
[0025] Furthermore, this module can also provide a user interface, which allows the operator to set treatment parameters such as electric field strength, pulse width, and frequency, and to display the treatment parameters, energy output status, and safety monitoring information in real time, so that the operator can start or stop the treatment.
[0026] 2. Treatment process image acquisition module. This module is used to acquire real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment.
[0027] In this module, real-time treatment images can be determined by various medical imaging techniques, such as ultrasound imaging, magnetic resonance imaging (MRI), optical coherence tomography (OCT), etc. The real-time acquired images can be stored in the medical system for subsequent analysis and comparison. Furthermore, multi-modal imaging fusion can also be performed, such as fusing ultrasound and MRI images to obtain more comprehensive tendon structure and function information.
[0028] In another embodiment, the above real-time treatment image is a PET / CT image. The method for acquiring the PET / CT image is as follows: For PET images, since certain key biomarkers, such as collagen, growth factors, and inflammatory factors, are involved in the repair and regeneration process during tendon repair, molecules that specifically bind to these biomarkers are selected as targets. Then, radioactive probes that can specifically bind to the target biomarkers are selected. For example, radioactive isotopes such as ¹ 8 F, ¹¹C, 68 Ga, etc. are used to label the molecular probes to ensure that they can target the tendon repair area.
[0029] After determining the radioactive probe, it is introduced into the anastomosis and peritendinous area of the target tendon by intravenous injection or local injection. The radioactive probe will reach the target area through blood circulation or local diffusion and bind to the specific biomarkers. Then, a PET detector is used to capture the γ photons generated by the annihilation of the positrons emitted by the radioactive probe. The PET device will record the position and intensity of the γ photons to generate a three-dimensional functional metabolic image, which is the above PET image.
[0030] For CT images, a CT scanner can be used to scan the target tendon area to obtain high-resolution anatomical structure images. Then, the PET image and the CT image are registered and fused to generate a PET / CT fusion image. The fusion image simultaneously displays the functional metabolic information and anatomical structure information of the tendon.
[0031] 3. Image analysis module. This module determines the radiopharmaceutical concentration of the target tendon through the real-time treatment image and performs quantitative analysis on the radiopharmaceutical concentration to obtain a dynamic time evolution curve reflecting the repair and healing process of the target tendon.
[0032] In this module, first, the signal intensity of the PET image at each time point is extracted, that is, the radioactive count. The signal intensity reflects the concentration of the radioactive probe in the target tendon. Then, the standardized uptake value SUV at each time point is calculated through the formula SUV = injected dose (MBq) / radioactivity (kBq / mL) in the ROI of weight (g). Then, with time as the horizontal axis and SUV as the vertical axis, a time-activity curve (TAC) of the target tendon area is plotted, and this curve reflects the dynamic distribution and metabolic process of the radioactive probe in the tendon.
[0033] Through the dynamic changes of the TAC, the metabolic activities in different stages of tendon repair, such as the inflammatory phase, proliferation phase, and scar phase, are evaluated. For example, during the inflammatory phase, the concentration of the radioactive probe is relatively high, reflecting the activity of inflammatory cells and repair factors; during the proliferation phase, the concentration of the radioactive probe gradually decreases, reflecting the progress of the repair process; during the scar phase, the concentration of the radioactive probe tends to be stable, reflecting the maturation of the tendon structure. Different probe concentration thresholds can be set for each stage, and the repair stage of the target tendon is determined through this threshold.
[0034] This module determines the radiopharmaceutical concentration of the target tendon through PET / CT images and plots a dynamic time evolution curve, which can quantitatively evaluate the metabolic activity and dynamic process of tendon repair. This method provides an important tool for tendon repair research and clinical practice, and can help doctors and researchers better understand the repair mechanism, optimize treatment plans, and achieve personalized treatment.
[0035] 4. Regulation module. This module is used to perform differential stimulation regulation on the anastomosis and peritendinous area of the target tendon according to the dynamic time evolution curve.
[0036] In this module, the differential stimulation regulation process is as follows Figure 2As shown. After the tendon trauma repair / rehabilitation treatment starts, move the matrix electrode to the position directly opposite the anastomosis site. Through real-time imaging monitoring by PET / CT and image quantitative analysis, it is determined in real time to activate low-intensity nanosecond pulsed electric field stimulation for regeneration at the end of tendon rehabilitation inflammation and the initial stage of hyperplasia, and turn off the low-intensity nanosecond pulsed electric field stimulation at the end of hyperplasia. Then move the matrix electrode to the peritendinous position. Through real-time imaging monitoring by PET / CT and image quantitative analysis, it is determined in real time to activate high-intensity nanosecond pulsed electric field ablation inhibition at the end of tendon rehabilitation hyperplasia and the initial stage of scar formation, and turn off the nanosecond pulsed electric field until the end of scarring, and the tendon trauma repair / rehabilitation treatment process ends.
[0037] Thus, the Figure 1 function description of each module in
[0038] In the embodiment of the present application, the system obtains real-time images during the pulsed electric field tendon functional trauma repair and rehabilitation treatment through the image acquisition module, and then determines the dynamic time evolution curve of the tendon repair and healing process according to the radiopharmaceutical concentration through the image analysis module. Finally, high- and low-intensity nanosecond pulsed electric fields are applied to the target tendon anastomosis and peritendinous positions in different healing states according to the curve, so as to achieve differential stimulation regulation. This improves the intelligence and accuracy of differential stimulation treatment of tendons by nanosecond pulsed electric fields.
[0039] In another embodiment, the above system further includes an electric field energy monitoring module; The electric field energy monitoring module is used to monitor the nanosecond pulsed electric field output by the pulsed electric field energy generation module according to a preset threshold range; When it is determined that the electric field parameters of the nanosecond pulsed electric field are not within the threshold range, the energy output of the pulsed electric field energy generation module is stopped, where the electric field parameters include voltage, pulse width, and frequency.
[0040] This module ensures the safety and effectiveness of the treatment by real-time monitoring of electric field parameters and ensuring that they are within the safe threshold range. The design and implementation of this module require the combination of high-precision sensing technology, real-time data processing technology, and reliable control logic to meet the requirements of tendon repair treatment.
[0041] In another embodiment, the above system further includes a current detection module; The current detection module is used to detect the current of the matrix electrode through a current sensor when the pulsed electric field energy generation module outputs a nanosecond pulsed electric field, and give an alarm when it is determined that the current of the matrix electrode exceeds the safety threshold.
[0042] This module sets a safety current threshold according to the electrode material and load. During the output of the nanosecond pulsed electric field, the current is continuously monitored by a current sensor. When the current exceeds the safety threshold, the system issues an alarm through means such as sound, light signals, or software notifications. This module ensures the safe operation of the pulsed electric field energy generation system through real-time monitoring, threshold judgment, and alarm mechanisms, preventing risks brought by abnormal current.
[0043] As Figure 3 shown, this application also provides a real-time image monitoring and regulation device in tendon trauma treatment. The device includes: A pulsed electric field energy generation unit 301 for outputting a nanosecond pulsed electric field to stimulate and treat the target tendon according to treatment parameters; A treatment process image acquisition unit 302 for acquiring real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment; An image analysis unit 303 for determining the radiopharmaceutical concentration of the target tendon through the real-time treatment images and performing quantitative analysis on the radiopharmaceutical concentration to obtain a dynamic time evolution curve reflecting the repair and healing process of the target tendon; A regulation unit 304 for performing differential stimulation regulation on the anastomosis and peritendinous regions of the target tendon according to the dynamic time evolution curve.
[0044] In another embodiment, the differential stimulation regulation of the anastomosis and peritendinous regions of the target tendon by the regulation unit according to the dynamic time evolution curve includes: Determining the healing state of the target tendon through the dynamic time evolution curve, where the healing state includes the inflammatory phase, the proliferative phase, and the scar phase; When it is determined that the target tendon is in the late inflammatory stage and the early proliferative stage, move the matrix electrode to the anastomosis of the target tendon, turn on the low-intensity nanosecond pulsed electric field for treatment, and turn off the low-intensity nanosecond pulsed electric field until it is determined that the target tendon is in the late proliferative stage; When it is determined that the target tendon is in the late proliferative stage and the early scar stage, move the matrix electrode to the peritendinous region of the target tendon, turn on the high-intensity nanosecond pulsed electric field for ablation inhibition, and turn off the high-intensity nanosecond pulsed electric field until it is determined that the target tendon is in the late scar stage.
[0045] In another embodiment, the real-time treatment image in the treatment process image acquisition unit is a PET / CT image; the acquisition of the real-time treatment image of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment includes: Determine a radioactive probe that specifically targets key biomarkers during tendon repair, and arrange the radioactive probe in the anastomosis and peritendinous regions of the target tendon; Capture the distribution and metabolism of the radioactive probe in the target tendon through a PET detector to obtain a PET image; Scan the target tendon with a CT scanner to obtain a CT image.
[0046] In another embodiment, the device further includes: An electric field energy monitoring unit 305, configured to monitor the nanosecond pulsed electric field output by the pulsed electric field energy generation module according to a preset threshold interval; When it is determined that the electric field parameters of the nanosecond pulsed electric field are not within the threshold interval, stop the energy output of the pulsed electric field energy generation module, where the electric field parameters include voltage, pulse width, and frequency; A current detection unit 306, configured to detect the current of the matrix electrode through a current sensor when the pulsed electric field energy generation module outputs a nanosecond pulsed electric field, and give an alarm when it is determined that the current of the matrix electrode exceeds a safety threshold.
[0047] In the above embodiments of the present invention, a real-time imaging monitoring and regulation system in tendon trauma treatment is provided, and based on this system, a real-time imaging monitoring and regulation device in tendon trauma treatment is provided. Through the above system and device, the intelligence and accuracy of differential stimulation treatment of tendons by nanosecond pulsed electric fields can be improved.
[0048] This embodiment also discloses a computer device, as Figure 4 shown, the computer device includes a processor and a memory, and at least one instruction is stored in the memory, and the at least one instruction is loaded and executed by the processor to implement the method on the real-time imaging monitoring and regulation system in tendon trauma treatment described in any one of the above.
[0049] In addition, in the implementation manner of the real-time imaging monitoring and regulation device in tendon trauma treatment in the above example, the logical division of each program module is only for illustration. In actual application, according to needs, for example, considering the configuration requirements of the corresponding hardware or the convenience of software implementation, the above functions can be assigned to different program modules to complete, that is, the internal structure of the real-time imaging monitoring and regulation device in tendon trauma treatment is divided into different program modules to complete all or part of the functions described above.
[0050] The above are only the preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included within the scope of protection of the present application.
Claims
1. A real-time imaging monitoring and regulation system in tendon trauma treatment, characterized in that, The system includes a pulsed electric field energy generation module, a treatment process image acquisition module, an image analysis module, and a regulation module; The pulsed electric field energy generation module is used to output a nanosecond pulsed electric field according to treatment parameters to stimulate and treat the target tendon; The treatment process image acquisition module is used to acquire real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process; The image analysis module determines the radiopharmaceutical concentration of the target tendon through the real-time treatment images, and performs quantitative analysis on the radiopharmaceutical concentration to obtain a dynamic time evolution curve reflecting the repair and healing process of the target tendon; The regulation module is used to perform differential stimulation regulation on the anastomosis and peritendinous regions of the target tendon according to the dynamic time evolution curve; 2. The system according to claim 1, wherein The differential stimulation regulation of the anastomosis and peritendinous regions of the target tendon according to the dynamic time evolution curve includes: Determining the healing state of the target tendon through the dynamic time evolution curve, and the healing state includes an inflammatory phase, a proliferation phase, and a scar phase; When it is determined that the target tendon is in the late inflammatory stage and the early proliferation stage, move the matrix electrode to the anastomosis of the target tendon, turn on the low-intensity nanosecond pulsed electric field for treatment, and turn off the low-intensity nanosecond pulsed electric field until it is determined that the target tendon is in the late proliferation stage; When it is determined that the target tendon is in the late proliferation stage and the early scar stage, move the matrix electrode to the peritendinous region of the target tendon, turn on the high-intensity nanosecond pulsed electric field for ablation inhibition, and turn off the high-intensity nanosecond pulsed electric field until it is determined that the target tendon is in the late scar stage; 3. The system according to claim 1, wherein The real-time treatment image is a PET / CT image; 4. The system according to claim 3, characterized in that, The acquisition of the real-time treatment image of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process includes: Determining a radioactive probe specific to the key biomarker during the tendon repair process, and arranging the radioactive probe in the anastomosis and peritendinous regions of the target tendon; Capturing the distribution and metabolism of the radioactive probe in the target tendon through a PET detector to obtain a PET image; Scanning the target tendon through a CT scanner to obtain a CT image; 5. The system according to claim 1, wherein The system further includes an electric field energy monitoring module; The electric field energy monitoring module is used to monitor the nanosecond pulsed electric field output by the pulsed electric field energy generation module according to a preset threshold interval; When it is determined that the electric field parameters of the nanosecond pulsed electric field are not within the threshold interval, stop the energy output of the pulsed electric field energy generation module, where the electric field parameters include voltage, pulse width, and frequency; 6. The system according to claim 1, wherein The system further includes a current detection module; The current detection module is used to detect the current between the matrix electrodes through a current sensor when the pulsed electric field energy generation module outputs a nanosecond pulsed electric field, and issue an alarm when it is determined that the current between the matrix electrodes exceeds the safety threshold; 7. A real-time imaging monitoring and regulation device in tendon trauma treatment, characterized in that, The device includes; A pulsed electric field energy generation unit, which is used to output a nanosecond pulsed electric field according to treatment parameters to stimulate and treat the target tendon; A treatment process image acquisition unit for acquiring real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process; An image analysis unit for determining the radiopharmaceutical concentration of the target tendon through the real-time treatment images and performing quantitative analysis on the radiopharmaceutical concentration to obtain a dynamic time evolution curve reflecting the repair and healing process of the target tendon; A regulation unit for performing differential stimulation regulation on the anastomosis and peritendinous regions of the target tendon according to the dynamic time evolution curve.
8. The device according to claim 7, wherein The differential stimulation regulation of the anastomosis and peritendinous regions of the target tendon by the regulation unit according to the dynamic time evolution curve includes: Determining the healing state of the target tendon through the dynamic time evolution curve, where the healing state includes the inflammatory phase, the proliferative phase, and the scar phase; When it is determined that the target tendon is in the late inflammatory stage and the early proliferative stage, moving the matrix electrode to the anastomosis of the target tendon and turning on a low-intensity nanosecond pulsed electric field for treatment until it is determined that the target tendon is in the late proliferative stage and then turning off the low-intensity nanosecond pulsed electric field; When it is determined that the target tendon is in the late proliferative stage and the early scar phase, moving the matrix electrode to the peritendinous region of the target tendon and turning on a high-intensity nanosecond pulsed electric field for ablation inhibition until it is determined that the target tendon is in the late scar phase and then turning off the high-intensity nanosecond pulsed electric field.
9. The device according to claim 7, characterized in that, The real-time treatment images in the treatment process image acquisition unit are PET / CT images; the acquisition of the real-time treatment images of the target tendon during the pulsed electric field tendon functional trauma repair and rehabilitation treatment process includes: Determining a radioactive probe specific to the key biomarker during the tendon repair process and arranging the radioactive probe in the anastomosis and peritendinous regions of the target tendon; Capturing the distribution and metabolism of the radioactive probe in the target tendon through a PET detector to obtain a PET image; Scanning the target tendon through a CT scanner to obtain a CT image.
10. The device according to claim 7, characterized in that, The device further includes: An electric field energy monitoring unit for monitoring the nanosecond pulsed electric field output by the pulsed electric field energy generation module according to a preset threshold range; When it is determined that the electric field parameters of the nanosecond pulsed electric field are not within the threshold range, stopping the energy output of the pulsed electric field energy generation module, where the electric field parameters include voltage, pulse width, and frequency; A current detection unit for detecting the current between the matrix electrodes through a current sensor when the pulsed electric field energy generation module outputs a nanosecond pulsed electric field and giving an alarm when it is determined that the current between the matrix electrodes exceeds the safety threshold.