Microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole

Abstract

The invention relates to the field of micro-channel reactors, in particular to a micro-channel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole. The reaction device comprises a reaction cylinder, a feeding piece, a discharging piece, a micro-channel reaction piece and a pressure adjusting assembly. The reaction cylinder rotationally penetrates through the shell in the length direction, one end is provided with a feeding pipe I, and the other end is provided with a discharging pipe; the feeding piece is located on one side of the shell and connected with the first feeding pipe. The discharging piece is located on the other side of the shell and connected with the discharging pipe; the micro-channel reaction parts form a micro-reaction flow channel by a plurality of groups of reaction plates, and the micro-channel reaction parts are arranged in the reaction cylinder in pairs; opening and closing of the two adjacent pairs of micro-channel reaction pieces are synchronous and opposite; and the pressure adjusting assembly is fixed between each pair of micro-channel reaction pieces. According to the invention, each reaction reagent is transferred from the water inlet end to the water outlet end in a segmented manner, segmented pressurization and filtration are carried out in the transfer process, and finally, the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole is efficiently completed.

Description

Technical Field

[0001] The present invention relates to the field of microchannel reactors, and particularly to a microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole. Background Art

[0002] When preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole, the general operation is to add methylhydrazine aqueous reagent (40%) and acetic acid into a reaction flask, and at a certain temperature, dropwise add ethyl trifluoroacetoacetate. After the reaction is completed, water several times the volume of acetic acid is added for cooling, filtration, washing, and then filtration again. The solid is dried to obtain the product. The above reaction has low efficiency, long time, and potential safety hazards.

[0003] A microchannel reactor is essentially a continuous-flow tubular reactor, and its channel size is usually in the micrometer to millimeter range. This tiny size design can significantly increase the contact area between reactants and catalysts, and at the same time reduce the mass transfer and heat transfer resistance during the reaction, being safe and efficient. Therefore, preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole through a microchannel reactor has certain application value.

[0004] Chinese Patent with the authorization announcement number CN117282395B discloses an anti-blocking microchannel reactor, including a microchannel reactor body and a filter cylinder shell. The front end of the filter cylinder shell is fixedly installed and communicated with a liquid inlet pipe, the rear end of the filter cylinder shell is fixedly installed and communicated with a liquid discharge pipe, the liquid discharge pipe is communicated with the input end of the microchannel reactor body, a filter plate is fixedly installed inside the filter cylinder shell, a filter chip is fixedly installed on the filter plate, a rotating shaft column is rotatably installed on the filter plate, an arc-shaped flow pusher is fixedly installed on the rotating shaft column, a filter core strip is installed at the tail end of the arc-shaped flow pusher, and a water inlet slot is arranged at the bottom end of the rotating shaft column, so that the reaction materials first react or dissolve with the reaction liquid in the filter cylinder shell.

[0005] The blockage of microchannel reactors is a common problem. In the prior art, the anti-blocking methods mainly focus on the pretreatment in the early stage, generally filtering the reagents before entering the microreaction channel. However, during the reaction process, due to the inherent properties of the products, for example, 1-methyl-3-trifluoromethyl-5-hydroxypyrazole itself is a powder, and it is easy to cause blockage after agglomerating and moving in the microreaction channel, thus affecting the preparation efficiency and effect. Summary of the Invention

[0006] Aiming at the problems in the background art, a microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole is proposed, which enables each reaction reagent to be transferred from the water inlet end to the water outlet end in segments, with pressure applied and filtration carried out in segments during the transfer process, and finally efficiently completes the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole.

[0007] The present invention provides a microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole, which comprises a reaction cylinder, a feeding member, a discharging member, a microchannel reaction member and a pressure regulating assembly. The reaction cylinder penetrates through the outer shell along the length direction and is rotationally connected with the outer shell through a first driving structure. One end is provided with a first feeding pipe, and the other end is provided with a discharging pipe. The feeding member is located on one side of the outer shell and is connected to the first feeding pipe. The discharging member is located on the other side of the outer shell and is connected to the discharging pipe. The microchannel reaction member consists of multiple groups of reaction plates to form a microreaction flow channel, and the microchannel reaction members are arranged in pairs in the reaction cylinder. Each pair of microchannel reaction members can move in an opening and closing manner along the horizontal direction through a second driving structure, and on the other hand, they rotate with the reaction cylinder. The adjacent two pairs of microchannel reaction members open and close synchronously and in opposite directions. The outermost two groups of microchannel reaction members are respectively communicated with the first feeding pipe and the discharging pipe. The pressure regulating assembly is fixed between each pair of microchannel reaction members. As the two sides of the microchannel reaction members open and close, the air inside the pressure regulating assembly is synchronously squeezed or stretched, and the flowing reagent is segmented and pressurized.

[0008] Preferably, the space between the outer shell and the reaction cylinder is filled with a heat-insulating agent.

[0009] Preferably, the first driving structures are respectively located at both ends of the reaction cylinder, and each includes a first gear driven by a first motor to rotate; a second gear is sleeved on the outer periphery of the reaction cylinder and meshes with the first gear.

[0010] Preferably, the second driving structure includes an adjusting rod arranged along the length direction of the reaction cylinder and driven to rotate by a driving box; the adjusting rod is provided with corresponding adjusting sections according to the number of pairs of microchannel reaction members; a pair of moving blocks realize the opening and closing movement by being respectively threadedly connected to both ends of the adjusting section; a first mounting frame is clamped outside the microchannel reaction member and is correspondingly connected to the moving block.

[0011] Preferably, connectors communicating with the head end and the tail end of the microreaction flow channel are respectively arranged on both sides of the microchannel reaction member; the connector at the forefront is connected to the first feeding pipe, the connector at the rearmost is connected to the discharging pipe, and the remaining connectors are connected to the pressure regulating assembly; the pressure regulating assembly includes two connecting pipes respectively connected to the connectors on the front and rear microchannel reaction members; the relative ends of the two connecting pipes respectively slide into the pressure regulating cylinder from both ends and are connected to a piston plate with a one-way valve; the one-way valves on the two piston plates control the reagent to enter from one side and exit from the other side; a filter screen is arranged between the two piston plates.

[0012] Preferably, the filter screen is a flexible filter screen; a deformable film connected to the edge position of the flexible filter screen is arranged in a circle on the side wall of the pressure regulating cylinder, and a rotatable adjusting ring is further arranged outside the pressure regulating cylinder; an airbag bag correspondingly covers the deformable film and is filled with gas inside; an extrusion member is arranged on the adjusting ring, and as the adjusting ring rotates, the airbag bags are sequentially extruded.

[0013] Preferably, extrusion members are arranged at intervals on the side wall of the adjusting ring; a third gear is sleeved on the end of the adjusting ring, and a fourth gear driven by a second motor to rotate is arranged on one side; the third gear is meshed with the fourth gear and is rotatably connected to the pressure adjusting cylinder; the extrusion member is wheel-shaped and can generate heat when electrified.

[0014] Preferably, the feeding member includes a second mounting frame; a plurality of discharging tanks are arranged in the second mounting frame, and a sampling pump corresponding to each discharging tank is arranged on the second mounting frame; each sampling pump transfers the corresponding reagent to the first feeding pipe by cooperating with the corresponding second feeding pipe.

[0015] Compared with the prior art, the present invention has the following beneficial technical effects: A reaction cylinder soaked by a heat preservation agent and capable of rotating around the origin is provided, so that each reaction reagent can ensure the temperature and be fully mixed during the moving process, achieving the purpose of efficient reaction. The paired microchannel reaction members are provided, and each pair of microchannel reaction members drives to move in an opening and closing manner in the horizontal direction by a second driving structure, and the adjacent two pairs of microchannel reaction members are synchronized and opposite in opening and closing, and the pressure regulating assembly is fixed between each pair of microchannel reaction members. This structure enables the two microchannel reaction members on both sides to be separated, the two connecting pipes drive the two piston plates to be separated, stretching the air in the pressure regulating cylinder, and when the two microchannel reaction members on both sides are closed, the two connecting pipes drive the two piston plates to be closed, squeezing the air in the pressure regulating cylinder. The pressure regulating assembly arranged along the reagent flow direction squeezes - closes - squeezes - closes in sequence, enabling the reagents in the adjacent microchannel reaction members to enter and exit alternately, pressurizing the reagents in sections, on the one hand, reducing the blockage of the microreaction flow channels, and on the other hand, accelerating the mixing and reaction. At the same time, by rotating the pressure regulating cylinder, the extrusion member is driven to squeeze the airbag; the deformable membrane deforms under the gas extrusion, driving the filter screen to deform, thereby achieving the purpose of cleaning and local pressurization. Finally, each reaction reagent is transferred from the water inlet end to the water outlet end in sections, pressurized and filtered in sections during the transfer process, and finally the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole is efficiently completed. Description of the Drawings

[0016] Figure 1 It is a schematic structural diagram of a microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole in the present invention; Figure 2 It is a sectional view of the outer shell in the present invention; Figure 3 It is a sectional view of the reaction cylinder in the present invention; Figure 4 It is Figure 2 The enlarged view at A in Figure 5 It is a schematic structural diagram of the second driving structure and the microchannel reaction member; Figure 6 It is a schematic structural diagram of the microchannel reaction member and the pressure regulating assembly; Figure 7 It is a schematic structural diagram of the pressure regulating component; Figure 8 It is a partial structural schematic diagram of the pressure regulating component; Figure 9 It is a partial sectional view of the pressure regulating component; Figure 10 It is a schematic structural diagram of the feeding part in the present invention.

[0017] Reference numerals: 1, feeding part; 101, mounting bracket II; 102, discharge tank; 103, feeding pipe II; 104, sampling pump; 2, outer shell; 3, discharging part; 4, reaction cylinder; 401, feeding pipe I; 402, discharging pipe; 403, driving structure I; 40301, motor I; 40302, gear I; 40303, gear II; 5, microchannel reaction part; 501, joint; 6, pressure regulating component; 601, connecting pipe; 602, pressure regulating cylinder; 603, piston plate; 604, filter screen; 605, deformable membrane; 606, airbag; 607, adjusting ring; 608, extruding part; 609, gear III; 610, gear IV; 611, motor II; 7, driving structure II; 701, adjusting rod; 702, driving box; 703, moving block; 704, mounting bracket I; 705, fixing rod. Detailed implementation manners

[0018] Example 1, as Figures 1 - 3 shown, a microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole proposed by the present invention includes a reaction cylinder 4, a feeding part 1, a discharging part 3, a microchannel reaction part 5 and a pressure regulating component 6. The reaction cylinder 4 penetrates through the outer shell 2 along the length direction and is rotationally connected to the outer shell 2 through the driving structure I 403, with a feeding pipe I 401 provided at one end and a discharging pipe 402 provided at the other end; the feeding part 1 is located on one side of the outer shell 2 and is connected to the feeding pipe I 401; the discharging part 3 is located on the other side of the outer shell 2 and is connected to the discharging pipe 402; the microchannel reaction part 5 is composed of multiple groups of reaction plates to form a microreaction flow channel, and the microchannel reaction part 5 is arranged in pairs in the reaction cylinder 4. On the one hand, each pair of microchannel reaction parts 5 makes an opening and closing movement along the horizontal direction through the driving structure II 7, and on the other hand, rotates with the reaction cylinder 4; the opening and closing of adjacent pairs of microchannel reaction parts 5 are synchronized and opposite; the outermost two groups of microchannel reaction parts 5 are respectively communicated with the feeding pipe I 401 and the discharging pipe 402; the pressure regulating component 6 is fixed between each pair of microchannel reaction parts 5. As the two sides of the microchannel reaction part 5 open and close, the air inside the pressure regulating component 6 is synchronously squeezed or stretched, pressurizing the flowing reagent in segments. Pressurizing the reagent can, on the one hand, accelerate its mixing and promote the reaction, and on the other hand, dredge the microreaction flow channel.

[0019] It should be further noted that the space between the outer shell 2 and the reaction cylinder 4 is filled with a heat-insulating agent; the temperature-control agent can be an oil liquid. The required temperature range for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole is about 40 °C. By heating the oil liquid, the reaction temperature is controlled to promote the smooth completion of the reaction.

[0020] As Figure 4 shown, the driving structure one 403 is respectively located at both ends of the reaction cylinder 4 and includes a gear one 40302 driven to rotate by a motor one 40301; a gear two 40303 is sleeved on the outer periphery of the reaction cylinder 4 and meshes with the gear one 40302. By driving the reaction cylinder 4 to rotate around the origin through the driving structure one 403, the microchannel reaction member 5 can be driven to rotate synchronously. This rotation process is beneficial to the mixing of each reaction reagent and also beneficial to maintaining the temperature stability.

[0021] As Figure 5 shown, the driving structure two 7 includes an adjusting rod 701 arranged along the length direction of the reaction cylinder 4 and driven to rotate by a driving box 702; the adjusting rod 701 is provided with corresponding adjusting sections according to the logarithm of the microchannel reaction members 5; a pair of moving blocks 703 realize opening and closing movements by being respectively threadedly connected to both ends of the adjusting section; a mounting frame one 704 is clamped outside the microchannel reaction member 5 and is correspondingly connected to the moving blocks 703 one by one.

[0022] It should be further noted that reverse threads are respectively arranged at both ends of each adjusting section, and the two moving blocks 703 are driven to translate and open and close through threaded connection.

[0023] It should be further noted that after the fixing rod 705 penetrates through the microchannel reaction member 5 from the periphery, the end penetrates through the mounting frame one 704 and is further locked by a nut, further locking the microchannel reaction member 5, reducing its liquid leakage, and also facilitating the adjustment of its movement.

[0024] It should be further noted that the mounting frame one 704 is of a U-shaped structure.

[0025] Through the driving structure two 7, the horizontal opening and closing movement of each pair of microchannel reaction members 5 can be realized, and the adjacent two pairs of microchannel reaction members 5 open and close synchronously but in opposite directions, that is, a cycle of squeezing-pulling-squeezing-pulling of the air inside the inner wall of the pressure regulating assembly 6 is formed, making the reagent flow coherent and the segmented pressurization efficient.

[0026] As Figure 6 shown, connectors 501 for connecting the head end and the tail end of the micro reaction flow channel are respectively arranged on both sides of the microchannel reaction member 5; the connector 501 at the forefront is connected to the feed pipe one 401, the connector 501 at the rearmost is connected to the discharge pipe 402, and the remaining connectors 501 are connected to the pressure regulating assembly 6.

[0027] As Figures 7 - 9As shown in the figure, the pressure regulating assembly 6 includes two sets of connecting pipes 601 respectively connected to the upper joints 501 of the front and rear microchannel reaction members 5; the opposite ends of the two sets of connecting pipes 601 slide into the pressure regulating cylinder 602 from both ends, and are connected to the piston plates 603 with one-way valves.

[0028] It should be further noted that the one-way valves on the two piston plates 603 control the reagent to enter from one side and exit from the other side; the filter screen 604 is arranged between the two piston plates 603.

[0029] When the current pair of microchannel reaction members 5 move closer together, the next pair of microchannel reaction members 5 move apart synchronously. The two sets of connecting pipes 601 on the pressure regulating assembly 6 between the previous pair of microchannel reaction members 5 drive the two piston plates 603 to approach each other, squeezing the air in the pressure regulating cylinder 602. The reagent is quickly filtered and transferred into the next pair of microchannel reaction members 5. At the same time, the two sets of connecting pipes 601 on the pressure regulating assembly 6 between the next pair of microchannel reaction members 5 drive the two piston plates 603 to separate, stretching the air in the pressure regulating cylinder 602. The original reagent in the next pair of microchannel reaction members 5 flows into the pressure regulating cylinder 602. By alternately introducing and discharging the reagent, the reagent is transferred from the water inlet end to the water outlet end. During the transfer process, the reagent is pressurized and filtered in sections. On the one hand, the flow rate of the reagent is kept changing dynamically, reducing the blockage of the microreaction flow channel and promoting the mixing reaction. On the other hand, the impurities and agglomerated reagents generated during the reaction process are filtered in time, further reducing the occurrence of blockage of the microreaction flow channel.

[0030] It should be further noted that the filter screen 604 is a flexible filter screen for the dispersed 1-methyl-3-trifluoromethyl-5-hydroxypyrazole powder to pass through; a deformable film 605 is arranged on the side wall of the pressure regulating cylinder 602 at a position connecting with the edge of the flexible filter screen. A rotatable adjusting ring 607 is also arranged around the pressure regulating cylinder 602; the airbag bags 606 respectively cover the deformable films 605 and are filled with gas inside; the squeezing member 608 is arranged on the adjusting ring 607, and as the adjusting ring 607 rotates, the airbag bags 606 are sequentially squeezed.

[0031] When cleaning the filter screen 604, rotate the pressure regulating cylinder 602 to drive the squeezing member 608 to rotate synchronously, and the airbag bags 606 can be sequentially squeezed. The deformable film 605 deforms under the gas extrusion, driving the filter screen 604 to deform, so as to achieve the purpose of cleaning it. In addition, the cleaning process can also squeeze the internal reagent to achieve the purpose of local pressurization, disperse the agglomerated products, intercept large-volume sundries, and thus facilitate improving the dredging effect.

[0032] It should be further noted that extrusion members 608 are arranged at intervals on the side wall of the adjusting ring 607; a third gear 609 is sleeved on the end of the adjusting ring 607, and a fourth gear 610 driven to rotate by a second motor 611 is arranged on one side; the third gear 609 is meshed and connected with the fourth gear 610 and is rotatably connected to the pressure adjusting cylinder 602; the extrusion member 608 is wheel-shaped and can generate heat when electrified.

[0033] Through the cooperation of the third gear 609 and the fourth gear 610, the adjusting ring 607 is driven to rotate. The extrusion member 608 moves synchronously with the adjusting ring 607. During the moving process, the airbag 606 deforms and recovers repeatedly, producing the effects of cleaning and pressurization. At the same time, the extrusion member 608 heats the air inside the airbag 606, causing its volume to expand and further increasing the extrusion effect.

[0034] As Figure 10 shown, the feeding member 1 includes a second mounting frame 101; a plurality of discharging tanks 102 are arranged inside the second mounting frame 101, and a sampling pump 104 connected to the plurality of discharging tanks 102 in one-to-one correspondence is arranged on the second mounting frame 101; each sampling pump 104 transfers the corresponding reagent to the first feeding pipe 401 by cooperating with the corresponding second feeding pipe 103. By setting the independent sampling method, the premature reaction of the reagent is avoided, and at the same time, the accuracy of sampling is ensured.

[0035] It should be further noted that three discharging tanks 102 are provided, which are respectively used for placing methylhydrazine hydrate reagent (40%), acetic acid addition, and ethyl trifluoroacetoacetate.

[0036] Example 2: Based on the microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole in Example 1, this example proposes a method for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole, and the steps are as follows: S1. The sampling pumps 104 respectively and independently sample methylhydrazine hydrate reagent (40%), acetic acid addition, and ethyl trifluoroacetoacetate into the reaction cylinder 4 in proportion; S2. Drive the reaction cylinder 4 to rotate at the original point through the first driving structure 403, and the microchannel reaction member 5 can be driven to rotate synchronously to achieve the purpose of mixing the reaction reagents; S3. The reagent sequentially passes through the paired microchannel reaction components 5. The horizontal opening and closing movement of each pair of microchannel reaction components 5 is driven by the second driving structure 7, and the opening and closing of adjacent pairs of microchannel reaction components 5 are synchronous but in opposite directions. When the current pair of microchannel reaction components 5 moves closer, the next pair of microchannel reaction components 5 moves apart synchronously. The two connecting pipes 601 on the pressure regulating component 6 between the current pair of microchannel reaction components 5 drive the two piston plates 603 to approach each other, squeezing the air in the pressure regulating cylinder 602. After the reagent is quickly filtered, it is transferred into the next pair of microchannel reaction components 5. At the same time, the two connecting pipes 601 on the pressure regulating component 6 between the next pair of microchannel reaction components 5 drive the two piston plates 603 to separate, stretching the air in the pressure regulating cylinder 602, and the original reagent in the next pair of microchannel reaction components 5 flows into the pressure regulating cylinder 602. S4. The filter screen 604 intercepts large-volume impurities and agglomerated products. By rotating the pressure regulating cylinder 602, the squeezing component 608 is driven to rotate synchronously, and the airbag 606 can be sequentially squeezed. Since the squeezing component 608 heats the air inside the airbag 606, its volume expands. The deformable film 605 deforms under the gas extrusion, driving the filter screen 604 to deform, thereby achieving the purpose of cleaning it and locally pressurizing to disperse the products. S5. By alternately introducing and discharging the reagent, the reagent is transferred from the water inlet end to the water outlet end in sections. During the transfer process, the reagent is pressurized and filtered in sections to complete the corresponding chemical reaction. At the same time, to ensure the reaction effect, the oil liquid is heated to control the reaction temperature at about 40 °C. S6. The prepared 1-methyl-3-trifluoromethyl-5-hydroxypyrazole enters the discharging component 3.

[0037] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to this. Within the scope of knowledge possessed by those skilled in the art to which the present invention pertains, various changes can be made without departing from the gist of the present invention.

Claims

1. A microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole, characterized in that, Comprising: A reaction cylinder (4), the reaction cylinder (4) penetrates through the outer shell (2) along the length direction and is rotationally connected to the outer shell (2) through a driving structure one (403), with a feed pipe one (401) provided at one end and a discharge pipe (402) provided at the other end; A feeding member (1), the feeding member (1) is located on one side of the outer shell (2) and is connected to the feed pipe one (401); A discharging member (3), the discharging member (3) is located on the other side of the outer shell (2) and is connected to the discharge pipe (402); A microchannel reaction member (5), the microchannel reaction member (5) consists of multiple groups of reaction plates to form a micro reaction flow channel, and the microchannel reaction member (5) is arranged in pairs in the reaction cylinder (4). Each pair of microchannel reaction members (5) is driven to move in an opening and closing manner in the horizontal direction through a driving structure two (7), and on the other hand, rotates with the reaction cylinder (4); adjacent pairs of microchannel reaction members (5) open and close synchronously and in opposite directions; the outermost two groups of microchannel reaction members (5) are respectively communicated with the feed pipe one (401) and the discharge pipe (402); And a pressure regulating assembly (6), the pressure regulating assembly (6) is fixed between each pair of microchannel reaction members (5). As the two sides of the microchannel reaction members (5) open and close, the air inside the pressure regulating assembly (6) is synchronously compressed or stretched, and the flowing reagent is segmented and pressurized.

2. The microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 1, characterized in that, The space between the outer shell (2) and the reaction cylinder (4) is filled with a heat-insulating agent.

3. The microchannel reactor for the preparation of 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 1, wherein, The driving structure one (403) is respectively located at both ends of the reaction cylinder (4), and includes a gear one (40302) driven to rotate by a motor one (40301); a gear two (40303) is sleeved on the outer circumference of the reaction cylinder (4) and meshes with the gear one (40302).

4. The microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 1, wherein The driving structure two (7) includes an adjusting rod (701) arranged along the length direction of the reaction cylinder (4) and driven to rotate by a driving box (702); the adjusting rod (701) is provided with corresponding adjusting sections corresponding to the number of pairs of microchannel reaction members (5); paired moving blocks (703) realize opening and closing movement by being respectively screwed to both ends of the adjusting section; a mounting frame one (704) is clamped outside the microchannel reaction member (5) and is respectively connected to the moving blocks (703).

5. The microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 1, wherein, Connectors (501) communicating with the head end and the tail end of the micro reaction flow channel are respectively arranged on both sides of the microchannel reaction member (5); the connector (501) at the forefront is connected to the feed pipe one (401), the connector (501) at the rearmost is connected to the discharge pipe (402), and the remaining connectors (501) are connected to the pressure regulating assembly (6); The pressure regulating assembly (6) includes two groups of connecting pipes (601) respectively connected to the connectors (501) on the front and rear microchannel reaction members (5); the opposite ends of the two groups of connecting pipes (601) respectively slide into the pressure regulating cylinder (602) from both ends and are connected to a piston plate (603) with a one-way valve; The one-way valves on the two groups of piston plates (603) control the reagent to enter from one side and exit from the other side; A filter screen (604) is arranged between the two groups of piston plates (603).

6. The microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 5, characterized in that, The filter screen (604) is a flexible filter screen; a deformable membrane (605) that is connected to the edge position of the flexible filter screen is provided in a circle on the side wall of the pressure adjustment cylinder (602), and a rotatable adjustment ring (607) is further provided in a circle outside the pressure adjustment cylinder (602); The airbag bags (606) cover the deformable membranes (605) one by one and are filled with gas inside; The extrusion members (608) are provided on the adjustment ring (607), and as the adjustment ring (607) rotates, the airbag bags (606) are sequentially extruded.

7. The microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 6, wherein, The extrusion members (608) are arranged at intervals on the side wall of the adjustment ring (607); a third gear (609) is sleeved on the end of the adjustment ring (607), and a fourth gear (610) driven to rotate by a second motor (611) is provided on one side; the third gear (609) is meshed and connected to the fourth gear (610) and is rotatably connected to the pressure adjustment cylinder (602); The extrusion members (608) are wheel-shaped and can generate heat when electrified.

8. The microchannel reactor for preparing 1-methyl-3-trifluoromethyl-5-hydroxypyrazole according to claim 1, wherein, The feeding member (1) includes a second mounting frame (101); a plurality of discharge tanks (102) are arranged inside the second mounting frame (101), and a sampling pump (104) connected to the plurality of discharge tanks (102) one by one is provided on the second mounting frame (101); each sampling pump (104) transfers the corresponding reagent to the first feeding pipe (401) by cooperating with the corresponding second feeding pipe (103).

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