Tablet grinding equipment for preparing medical drugs

Abstract

The invention discloses tablet grinding equipment for preparing medical drugs. The tablet grinding equipment comprises an equipment box, a first-stage grinding mechanism, a second-stage grinding mechanism and a third-stage grinding mechanism, a row of feeding hoppers are arranged at the top of the equipment box; the primary grinding mechanism comprises a grinding pipeline, a grinding roller and a brush; the secondary grinding mechanism comprises a quantitative discharging auger and an extrusion grinding barrel, the quantitative discharging auger comprises a vertical barrel body, an auger and a discharging servo motor, and an extrusion grinding threaded rod is arranged in the extrusion grinding barrel; the third-stage grinding mechanism comprises a grinding tank, a grinding ball and a collecting box, the bottom of the grinding tank is a hemispherical bottom, and the grinding ball is vase-shaped. Raw materials enter the grinding pipeline, can slide downwards and are extruded and ground from the bottom of the grinding roller, medicine powder is subjected to threaded extrusion and grinding through the extrusion grinding threaded rod rotating at a constant speed, the finer grinding effect is further achieved, the grinding ball and the grinding tank are extruded, the effect like manual grinding through a grinder is achieved, and the grinding effect is better.

Description

Technical Field

[0001] The invention relates to the technical field of tablet preparation, and in particular to a tablet grinding device for preparing medical drugs. Background Art

[0002] Tablets contain multiple ingredients, and the content of the main ingredient is relatively low. In order to make the main ingredients in the tablets uniform and meet the dosage requirements of the tablets, all ingredients need to be mixed evenly during the preparation process. The raw materials of the main ingredients need to be ground, and grinding can reduce the particle size of the drug and increase the specific surface area of the drug. In this way, after entering the human body, the contact area between the drug and the liquid in the gastrointestinal tract increases, the dissolution rate is accelerated, and it can be absorbed into the blood circulation faster, thereby improving the solubility and bioavailability of poorly soluble drugs, so that the drugs can better exert their therapeutic effects. Manual grinding is too costly for enterprises, and equipment grinding needs to be thorough, and the grinding process does not damage the medicinal properties of the raw materials. At the same time, the ability to grind and mix multiple ingredients at the same time will greatly reduce the production cost and improve production efficiency. However, the existing grinding is to grind the raw materials independently, and later mixing is required, which is cumbersome to operate and has high production costs. Summary of the invention

[0003] The present invention aims to solve at least one of the technical problems in the related art to a certain extent. To this end, one purpose of the present invention is to provide a tablet grinding device for preparing medical drugs, which solves the problems of low grinding efficiency, inability to grind multiple raw materials at the same time and mix them at the same time.

[0004] A tablet grinding device for preparing medical drugs according to the present invention comprises an equipment box and a primary grinding mechanism, a secondary grinding mechanism and a tertiary grinding mechanism arranged in the equipment box;

[0005] A row of hoppers is provided at the top of the equipment box near the left side wall, and a blocking plate is provided above the equipment box. The blocking plate is pushed and pulled by a push cylinder;

[0006] The primary grinding mechanism comprises a grinding pipe, a grinding roller and a brush. The top ends of the plurality of grinding pipes are connected to the bottom ends of a feeding hopper, and the bottom ends are gathered into a gathering box. The grinding pipe is tilted downward, the upper part of the grinding pipe is a square pipe, and the lower part is a semi-elliptical pipe. The grinding roller has a semi-elliptical edge around it. The center position of the grinding roller is rotatably mounted on the grinding pipe by a shaft, and one end of the shaft is connected to the first servo motor shaft. The semi-elliptical edge around the grinding roller matches the inner wall of the semi-elliptical pipe and leaves a gap of 3-8mm. 3-5 grinding rollers are arranged at equal intervals from top to bottom in the grinding pipe, and a brush is arranged on the rear side of each grinding roller and the brush is fixedly installed in the grinding pipe;

[0007] The secondary grinding mechanism includes a quantitative feeding auger and an extrusion grinding cylinder. The quantitative feeding auger includes a vertical cylinder body, an auger, and a feeding servo motor. The vertical cylinder body is provided with an auger inside. The feeding servo motor is fixed on the top wall of the equipment box, and its rotating shaft extends downward through the vertical cylinder body and sleeves the auger on the rotating shaft. The extrusion grinding cylinder is provided with an extrusion grinding screw rod. A mechanical sleeve is movably sleeved on the left end of the extrusion grinding screw rod. A second servo motor is provided at the left end of the extrusion grinding cylinder, and the rotating shaft of the second servo motor is connected to the left end of the extrusion grinding screw rod. The right end of the extrusion grinding cylinder is open. The bottom of the vertical cylinder body is open, and the bottom of the vertical cylinder body communicates with the middle position of the left half of the extrusion grinding cylinder.

[0008] The tertiary grinding mechanism includes a grinding tank, grinding balls, and a collection box. The bottom of the grinding tank is a hemispherical bottom. An inlet is provided on the side wall of the grinding tank near the top. The open position at the right end of the extrusion grinding cylinder is inserted into the inlet. The grinding balls are vase-shaped, and the lower half is a hemisphere. The diameter of the hemisphere at the lower half of the grinding ball is 5 - 8 mm smaller than the inner diameter of the hemispherical bottom of the grinding tank. A support column is provided at the middle position of the inner bottom of the grinding tank. The bottom of the grinding ball is rotatably sleeved on the support column. A grinding shaft rod passes through the center position of the grinding ball. A third servo motor is provided on the top of the equipment box, and the rotating shaft of the third servo motor is connected to the grinding shaft rod. Powder discharge holes are evenly distributed on the hemispherical bottom wall of the grinding tank. The collection box is sleeved outside the hemispherical bottom of the grinding tank. An inclined discharge channel is provided at the bottom of the collection box, and the discharge channel passes through the right side wall of the equipment box and extends to the outside.

[0009] In some embodiments of the present invention, the grinding pipeline is inclined downward at an angle of 30 - 45°. The distance between the semi-elliptical edge of the grinding roller in the grinding pipeline and the inner wall of the semi-elliptical pipe of the grinding pipeline gradually decreases from top to bottom, with a maximum distance of 7 - 8 mm and a minimum distance of 3 - 4 mm.

[0010] In some other embodiments of the present invention, the thread profile of the extrusion grinding screw rod is trapezoidal. The length of the upper side of the trapezoid is 4 - 6 mm, the length of the lower side is 8 - 12 mm. The distance between the threads of the extrusion grinding screw rod is 6 - 10 mm. A distance of 3 - 5 mm is maintained between the upper side of the trapezoid and the inner wall of the extrusion grinding cylinder.

[0011] In some other embodiments of the present invention, the extrusion grinding cylinder is horizontally arranged or inclined downward at 5 - 15°.

[0012] In some other embodiments of the present invention, the inside of the grinding ball is a hollow cavity, and the wall of the grinding ball is a 5 - 10 mm stainless steel wall.

[0013] In some other embodiments of the present invention, the grinding roller includes a stainless steel disc in the center and a rubber semi-elliptical edge sleeved around the stainless steel disc.

[0014] In some other embodiments of the present invention, a heating device is provided on the outer wall of the grinding tank, and the heating device can keep the temperature inside the grinding tank at 40 - 45 °C.

[0015] In some other embodiments of the present invention, the number of the row of feeding hoppers is not less than three, and each feeding hopper is used to deliver one kind of raw material.

[0016] In the present invention, several raw materials can be evenly fed in proportion from different feeding hoppers. The raw materials will slide downwards when entering the grinding pipeline. When sliding under the grinding rollers, they will be extruded and ground. After passing through several grinding rollers, a primary grinding effect is achieved. Then they converge and slide into the vertical cylinder, and are evenly fed into the extrusion grinding cylinder through the auger. The powder is pushed and extruded by the extrusion grinding screw rod rotating at a constant speed, and the powder is extruded and ground by the thread, further achieving a finer grinding effect. Finally, it slides into the grinding tank, and through the extrusion between the rotating grinding balls and the grinding tank, it achieves the effect of manual grinding with a grinding tool, and moreover, the grinding force is greater and the grinding effect is better. Description of the Drawings

[0017] The drawings are used to provide further understanding of the present invention, and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention, and do not constitute a limitation to the present invention. In the drawings:

[0018] Figure 1 is a schematic structural diagram of a tablet grinding device for medical drug preparation proposed by the present invention.

[0019] Figure 2 is a schematic internal sectional structure diagram of a tablet grinding device for medical drug preparation proposed by the present invention.

[0020] Figure 3 is a schematic sectional structure diagram of the re - grinding roller position of the grinding pipeline proposed by the present invention.

[0021] Figure 4 is a schematic structural diagram of the connection of the grinding pipeline to the converging box proposed by the present invention.

[0022] In the figure: 1, equipment box; 11, feeding hopper; 111, blocking plate; 112, pushing cylinder; 12, discharge channel; 2, feeding servo - motor; 21, vertical cylinder; 3, third servo - motor; 4, grinding pipeline; 40, semi - elliptical pipe; 41, grinding roller; 42, brush; 43, first servo - motor; 5, extrusion grinding cylinder; 51, extrusion grinding screw rod; 52, second servo - motor; 6, grinding tank; 61, powder outlet; 62, support column; 7, collection box; 8, grinding ball. Detailed Embodiments

[0023] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0024] like Figures 1-4 As shown, a tablet grinding device for preparing medical drugs proposed by the present invention comprises an equipment box 1 and a primary grinding mechanism, a secondary grinding mechanism and a tertiary grinding mechanism arranged in the equipment box 1;

[0025] A row of hoppers 11 are provided at the top of the equipment box 1 near the left side wall, and a blocking plate 111 is provided above the equipment box 1. The blocking plate 111 is pulled out by pushing the cylinder 112;

[0026] The primary grinding mechanism includes a grinding pipe 4, a grinding roller 41 and a brush 42. The tops of the plurality of grinding pipes 4 are connected to the bottom of a feeding hopper 11, and the bottom ends are gathered into a gathering box. The grinding pipe 4 is tilted downward, the upper part of the grinding pipe 4 is a square pipe, and the lower part is a semi-elliptical pipe 40. The grinding roller 41 has a semi-elliptical edge around it. The center position of the grinding roller 41 is rotatably mounted on the grinding pipe 4 by an axle, and one end of the axle is connected to the first servo motor 43. The semi-elliptical edge around the grinding roller 41 matches the inner wall of the semi-elliptical pipe 40 and leaves a gap of 3-8mm. 3-5 grinding rollers 41 are arranged at equal intervals from top to bottom in the grinding pipe 4, and a brush 42 is arranged on the rear side of each grinding roller 41, and the brush 42 is fixedly mounted in the grinding pipe 4;

[0027] At the beginning, the raw materials will be in agglomeration or agglomeration. After being thrown from the feeding hopper 11 (the unused lower hopper is blocked with a blocking plate), they will slide down to the grinding roller 41, where they will be split and pressed for primary pressing and grinding. After multiple times, they will be ground into a mixture of small particles and powders, and the particle size will not exceed 3mm. Multiple raw materials can be ground separately for primary grinding.

[0028] The secondary grinding mechanism includes a quantitative unloading auger and an extrusion grinding cylinder 5, the quantitative unloading auger includes a vertical cylinder 21, an auger and a unloading servo motor 2, an auger is arranged in the vertical cylinder 21, the unloading servo motor 2 is fixed on the top wall of the equipment box 1 and extends the rotating shaft downward to penetrate into the vertical cylinder 21 and sleeves the auger on the rotating shaft, an extrusion grinding threaded rod 51 is arranged in the extrusion grinding cylinder 5, a mechanical sleeve is movably sleeved on the left end of the extrusion grinding threaded rod 51, a second servo motor 52 is arranged on the left end of the extrusion grinding cylinder 5 and the rotating shaft of the second servo motor 52 is connected to the left end of the extrusion grinding threaded rod 51, the right end of the extrusion grinding cylinder 5 is open, the bottom of the vertical cylinder 21 is open and the bottom of the vertical cylinder 21 is connected to the middle position of the left half of the extrusion grinding cylinder 5;

[0029] After the raw materials converge, they enter the vertical cylinder 21, and are quantitatively fed through the auger, and then enter the extrusion and grinding cylinder 5 for pushing the material. During the pushing process of the powder, it will be extruded and ground, so that the powder is mixed and further ground. Then it is pushed out from the opening at the right end of the extrusion and grinding cylinder 5 and falls into the grinding tank 6.

[0030] The three-stage grinding mechanism includes a grinding tank 6, grinding balls 8 and a collection box 7. The bottom of the grinding tank 6 is a hemispherical bottom. There is a feeding port on the side wall of the grinding tank 6 near the top. The opening position at the right end of the extrusion and grinding cylinder 5 is inserted into the feeding port. The grinding balls 8 are vase-shaped and the lower half is a hemisphere. The diameter of the hemisphere at the lower half of the grinding ball 8 is 5-8 mm smaller than the inner diameter of the hemispherical bottom of the grinding tank 6. There is a support column 62 at the middle position of the inner bottom of the grinding tank 6. The bottom of the grinding ball 8 is rotatably sleeved on the support column 62. A grinding shaft rod penetrates through the center position of the grinding ball 8. There is a third servo motor 3 on the top of the equipment box 1 and the rotating shaft of the third servo motor 3 is connected to the grinding shaft rod. Powder discharge holes 61 are evenly distributed on the hemispherical bottom wall of the grinding tank 6. The collection box 1 is sleeved outside the hemispherical bottom of the grinding tank 6. There is an inclined discharge channel 12 at the bottom of the collection box 7 and the discharge channel 12 penetrates through the right side wall of the equipment box and extends to the outside.

[0031] In the grinding tank 6, the grinding balls 8 grind the powder by extrusion like manual grinding. During the downward movement, it is extruded from the powder discharge holes 61 and falls. The grinding balls 8 are vase-shaped to prevent powder from accumulating on the top of the grinding balls 8, and the powder will slide down automatically. The top of the support column is hemispherical, so that the bottom of the grinding ball 8 does not contact the inner bottom of the grinding tank 6 and can still ensure rotation.

[0032] The downward inclination angle of the grinding pipeline 4 is 30-45°. The distance between the semi-elliptical edge of the grinding roller in the grinding pipeline 4 and the inner wall of the semi-elliptical pipe 40 of the grinding pipeline 4 gradually becomes smaller from top to bottom, with the maximum distance being 7-8 mm and the minimum distance being 3-4 mm. The raw materials can slide down, and with the vibration of the motor, the powder will slide down and will not accumulate. It is pressed and crushed step by step and ground into powder.

[0033] The thread profile of the extrusion and grinding screw rod 51 is trapezoidal. The length of the upper side of the trapezoid is 4-6 mm, the length of the lower side is 8-12 mm, the distance between the threads of the extrusion and grinding screw rod 51 is 6-10 mm, and the distance between the upper side of the trapezoid and the inner wall of the extrusion and grinding cylinder 5 is 3-5 mm. It is set according to the grinding requirements. During the process of adding oil to the particles, they will be finer and will not get stuck.

[0034] The extrusion and grinding cylinder 5 is horizontally arranged or arranged with a downward inclination of 5-15°. Horizontally setting or appropriate inclination is convenient for discharging and extrusion and grinding. If the inclination angle is too large, the powder entering the extrusion and grinding screw rod 51 will accumulate at one point.

[0035] The interior of the grinding ball 8 is a hollow cavity, and the wall of the grinding ball 8 is a stainless steel wall with a thickness of 5-10 mm.

[0036] With a certain stiffness, the grinding ball 8 is not too heavy and is convenient to operate.

[0037] The grinding roller 41 includes a stainless steel disc at the center and a rubber semi-elliptical edge sleeved around the stainless steel disc, which has a certain elastic extrusion effect.

[0038] A heating device is provided on the outer wall of the grinding tank 6, and the heating device can keep the temperature inside the grinding tank at 40-45 °C. The powder is heated to a certain extent inside the grinding tank 6 to prevent the powder from caking due to moisture. A water-absorbing cotton is provided at the top inside the grinding tank, and it can be replaced regularly.

[0039] The number of the feeding hoppers 11 in a row is not less than three, and each feeding hopper 11 is used to feed a raw material. Multiple raw materials can be ground synchronously, and ground and mixed according to the proportion of feeding.

[0040] As mentioned above, the above is only the preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A tablet grinding device for the preparation of medical drugs, characterized in that: It includes an equipment box (1) and a primary grinding mechanism, a secondary grinding mechanism, and a tertiary grinding mechanism arranged inside the equipment box (1); At the top near the left side wall of the equipment box (1), there is a row of feeding hoppers (11). Above the equipment box (1), the feeding hoppers (11) are provided with a blocking plate (111), and the blocking plate (111) is pushed and pulled by a pushing cylinder (112); The primary grinding mechanism includes grinding pipes (4), grinding rollers (41), and brushes (42). The tops of multiple grinding pipes (4) are connected to the bottom end of one feeding hopper (11), and the bottom ends converge into a converging box. The grinding pipes (4) are inclined downward. The upper part of the grinding pipe (4) is a square pipe, and the lower part is a semi-elliptical pipe (40). The circumference of the grinding roller (41) is a semi-elliptical edge. The center of the grinding roller (41) is rotatably installed on the grinding pipe (4) with a shaft rod. One end of the shaft rod is connected to the shaft of the first servo motor (43). The semi-elliptical edge of the circumference of the grinding roller (41) matches the inner wall of the semi-elliptical pipe (40) with a gap of 3 - 8 mm. There are 3 - 5 grinding rollers (41) arranged at equal intervals from top to bottom in the grinding pipe (4). Behind each grinding roller (41), there is a brush (42), and the brush (42) is fixedly installed in the grinding pipe (4); The secondary grinding mechanism includes a metering feeding auger and an extrusion grinding cylinder (5). The metering feeding auger includes a vertical cylinder body (21), an auger, and a feeding servo motor (2). An auger is arranged inside the vertical cylinder body (21). The feeding servo motor (2) is fixed on the top wall of the equipment box (1), and its rotating shaft extends downward through the vertical cylinder body (21) and slews the auger on the rotating shaft. Inside the extrusion grinding cylinder (5), there is an extrusion grinding screw rod (51). The left end of the extrusion grinding screw rod (51) is movably sleeved with a mechanical sleeve. At the left end of the extrusion grinding cylinder (5), there is a second servo motor (52), and the rotating shaft of the second servo motor (52) is connected to the left end of the extrusion grinding screw rod (51). The right end of the extrusion grinding cylinder (5) is open. The bottom of the vertical cylinder body (21) is open, and the bottom of the vertical cylinder body (21) is communicated with the middle position of the left half of the extrusion grinding cylinder (5); The three-stage grinding mechanism includes a grinding tank (6), grinding balls (8), and a collection box (7). The bottom of the grinding tank (6) is a hemispherical bottom. There is a feeding port on the side wall of the grinding tank (6) near the top. The opening position at the right end of the extrusion grinding cylinder (5) is inserted into the feeding port. The grinding balls (8) are vase-shaped and the lower half is a hemisphere. The diameter of the hemisphere at the lower half of the grinding ball (8) is 5 - 8 mm smaller than the inner diameter of the hemispherical bottom of the grinding tank (6). In the middle position at the inner bottom of the grinding tank (6), there is a support column (62). The bottom of the grinding ball (8) is rotatably sleeved on the support column (62). A grinding shaft rod penetrates through the center position of the grinding ball (8). There is a third servo motor (3) on the top of the equipment box (1), and the rotating shaft of the third servo motor (3) is connected to the grinding shaft rod. Powder discharge holes (61) are evenly distributed on the hemispherical bottom wall of the grinding tank (6). The collection box (1) is sleeved outside the hemispherical bottom of the grinding tank (6). An inclined discharge channel (12) is provided at the bottom of the collection box (7), and the discharge channel (12) penetrates through the right side wall of the equipment box and extends to the outside.

2. The tablet grinding device for preparing a medical drug according to claim 1, wherein: The downward inclination angle of the grinding pipeline (4) is 30 - 45°. The distance between the semi-elliptical edge of the grinding roller in the grinding pipeline (4) and the inner wall of the semi-elliptical pipe (40) of the grinding pipeline (4) gradually decreases from top to bottom, with a maximum distance of 7 - 8 mm and a minimum distance of 3 - 4 mm.

3. A tablet grinding device for preparing a medical drug according to claim 1, characterized in that: The thread profile of the extrusion grinding screw rod (51) is trapezoidal. The length of the upper side of the trapezoid is 4 - 6 mm, the length of the lower side is 8 - 12 mm. The distance between the threads of the extrusion grinding screw rod (51) is 6 - 10 mm. There is a distance of 3 - 5 mm between the upper side of the trapezoid and the inner wall of the extrusion grinding cylinder (5).

4. A tablet grinding device for preparing a medical drug according to claim 1, characterized in that: The extrusion grinding cylinder (5) is horizontally arranged or arranged with a downward inclination of 5 - 15°.

5. A tablet grinding device for preparing a medical drug according to claim 1, characterized in that: The inside of the grinding ball (8) is a hollow cavity, and the wall of the grinding ball (8) is a 5 - 10 mm stainless steel wall.

6. A tablet grinding device for preparing a medical drug according to claim 1, characterized in that: The grinding roller (41) includes a stainless steel disc in the center and a rubber semi-elliptical edge sleeved around the stainless steel disc.

7. A tablet grinding device for preparing a medical drug according to claim 1, characterized in that: A heating device is provided on the outer wall of the grinding tank (6), and the heating device can keep the inside of the grinding tank at 40 - 45 °C.

8. A tablet grinding device for preparing a medical drug according to claim 1, characterized in that: The number of the row of feeding hoppers (11) is not less than three, and each feeding hopper (11) is used to deliver a kind of raw material.

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