Blood glucose detection method, blood glucose detection device and storage medium

Abstract

The invention discloses a blood glucose detection method, a blood glucose detection device and a storage medium, and relates to the technical field of blood glucose detection.The blood glucose detection method is applied to the blood glucose detection device, the blood glucose detection device comprises a sensor and an emitter, the sensor and the emitter are arranged in a separable mode, and the blood glucose detection method comprises the steps that the sensor and the emitter are connected, the sensor and the transmitter carry out information matching; confirming that the information of the sensor and the transmitter is successfully matched, and extracting human tissue fluid of the to-be-detected person by the sensor through counter-ion electroosmosis to obtain a glucose concentration value; and sending the glucose concentration value to an emitter to obtain a target blood glucose value. According to the blood glucose detection method, the blood glucose detection complexity is reduced, and the use convenience of the blood glucose detection device is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of blood glucose detection, and particularly to a blood glucose detection method, a blood glucose detection device and a storage medium. Background Art

[0002] Continuous blood glucose detection is to detect blood glucose through electrochemical reaction by a blood glucose detection device for a long time (such as 7 days, 14 days or up to 21 days) without interruption to judge the health status.

[0003] In the existing blood glucose detection device, the sensor and the transmitter are separable structures. During daily use, the user needs to pair and connect with the sensor and the transmitter respectively, making the pairing process cumbersome and complex, and the convenience of user use is poor. Summary of the Invention

[0004] The main object of the present invention is to propose a blood glucose detection method, a blood glucose detection device and a storage medium, aiming to reduce the complexity of blood glucose detection and improve the convenience of use of the blood glucose detection device through the blood glucose detection method.

[0005] To achieve the above object, the present invention proposes a blood glucose detection method, which is applied to a blood glucose detection device. The blood glucose detection device includes a sensor and a transmitter, and the sensor and the transmitter are separable. The steps of the blood glucose detection method include: Connect the sensor and the transmitter, and the sensor and the transmitter perform information matching; Confirm that the information matching between the sensor and the transmitter is successful, and the sensor extracts the body tissue fluid of the person to be tested through counterion electroosmosis to obtain the glucose concentration value; Send the glucose concentration value to the transmitter to obtain the target blood glucose value.

[0006] In an embodiment, the step of connecting the sensor and the transmitter, and the sensor and the transmitter performing information matching includes: Confirm that the sensor is in a worn state; In the worn state, the sensor and the transmitter perform wireless authentication matching to obtain the first matching information; Confirm that the sensor and the transmitter are in a connected state to obtain the second matching information; Confirm that the information matching between the sensor and the transmitter is successful according to the first matching information and the second matching information.

[0007] In an embodiment, the first matching information includes at least one of the following: The sensor device identity identifier and the transmitter device identity identifier; The first communication state between the sensor and the transmitter, where the first communication state includes connected and disconnected; The current first detection state of the sensor, where the first detection state includes timed detection, continuous detection, and stop detection.

[0008] In one embodiment, the second matching information includes at least one of the following: The second communication state between the sensor and the transmitter, where the second communication state includes connected and disconnected; The current second detection state of the sensor, where the second detection state includes timed detection, continuous detection, and stop detection; The third communication state between the transmitter and an external electronic device, where the third communication state includes connected and disconnected; The sampling parameters of the sensor, where the sampling parameters include sampling current value, sampling frequency, sampling time, and range.

[0009] In one embodiment, after confirming that the information of the sensor and the transmitter matches successfully based on the first matching information and the second matching information, the steps of connecting the sensor and the transmitter and the sensor and the transmitter performing information matching further include: Disconnect the wireless authentication matching between the sensor and the transmitter, and stop obtaining the first matching information; Keep the sensor and the transmitter in a connected state, and continuously obtain the second matching information.

[0010] In one embodiment, after sending the target blood glucose electrical signal to the transmitter to obtain the target blood glucose value, the steps of the blood glucose detection method further include terminating the detection, and the steps of terminating the detection include: Detect that the circuit conduction between the sensor and the transmitter is interrupted, and the transmitter stops obtaining the second matching information; Enable the wireless authentication matching between the sensor and the transmitter, and re-obtain the first matching information; The transmitter stores the first matching information, or sends the first matching information to a mobile terminal; The sensor stops extracting the body tissue fluid of the person to be tested.

[0011] In one embodiment, the sensor includes an extraction electrode and a detection electrode. The steps of confirming that the information of the sensor and the transmitter matches successfully and the sensor extracting the body tissue fluid of the person to be tested by anti-ion electroosmosis to obtain the glucose concentration value include: Within a first preset time, the extraction electrode pre-extracts the body tissue fluid of the person to be tested to obtain a test response current value; Based on the measured response current value, confirm that the blood glucose detection device is in a stable state; Within a second preset time, the extraction electrode obtains a tissue fluid sample of the person to be tested; The detection electrode obtains the glucose concentration value in the tissue fluid based on the tissue fluid sample.

[0012] In one embodiment, after the detection electrode obtains the glucose concentration value in the tissue fluid based on the tissue fluid sample, the step of obtaining the glucose concentration value further includes: Obtain a historical stable glucose concentration value; Compare the current glucose concentration value with the historical stable glucose concentration value to confirm whether the current glucose concentration value is within a stable range; If so, send the current glucose concentration value to the transmitter to obtain the target blood glucose value; If not, discard the abnormal value in the current glucose concentration value, re-obtain the glucose concentration value, and confirm again whether the current glucose concentration value is within a stable range.

[0013] The present invention also provides a blood glucose detection device, which includes: A sensor, the sensor is provided with a first conductive member; and A transmitter, the transmitter is detachably connected to the sensor, the transmitter is provided with a second conductive member, the blood glucose detection device has a connection state in which the sensor and the transmitter are connected, and in the connection state, the first conductive member and the second conductive member are in contact and the circuit is conducted.

[0014] The present invention also provides a storage medium, the storage medium is a computer-readable storage medium, and a computer program is stored on the storage medium. When the computer program is executed by a processor, the steps of the blood glucose detection method according to any one of claims 1 to 8 are implemented.

[0015] The steps of the blood glucose detection method of the technical solution of the present invention include: connecting a sensor and a transmitter, and the sensor and the transmitter perform information matching; confirming that the information matching between the sensor and the transmitter is successful, and the sensor extracts the body tissue fluid of the person to be tested through anti-ion electroosmosis to obtain a glucose concentration value; sending the glucose concentration value to the transmitter to obtain a target blood glucose value. In this application, the blood glucose detection method is applied to a blood glucose detection device. The blood glucose detection device includes a sensor and a transmitter, and the sensor and the transmitter can be detachably arranged. When the person to be tested wears the sensor and installs and connects the transmitter to the sensor, the transmitter can directly perform information matching and pairing connection with the sensor, so as to avoid the user from performing information matching with the sensor and the transmitter separately at the same time, reduce the complexity of the pairing process, and improve the convenience of user use. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on the structures shown in these drawings.

[0017] Figure 1 It is a schematic diagram of the steps of the blood glucose detection method in an embodiment of the present invention; Figure 2 It is a schematic diagram of the steps of information matching between the sensor and the transmitter in an embodiment of the present invention; Figure 3 It is a schematic diagram of the steps of terminating the detection in an embodiment of the present invention; Figure 4 It is a schematic diagram of the steps of obtaining the glucose concentration value in an embodiment of the present invention; Figure 5 It is a schematic diagram of the modules of the blood glucose detection device in an embodiment of the present invention.

[0018] The realization, functional features and advantages of the object of the present invention will be further described in conjunction with the embodiments with reference to the drawings. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the scope of protection of the present invention.

[0020] It should be noted that if there are directional indications (such as up, down, left, right, front, back...) involved in the embodiments of the present invention, the directional indications are only used to explain the relative positional relationship, movement conditions, etc. between components in a specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0021] In addition, if there are descriptions such as "first", "second", etc. involved in the embodiments of the present invention, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, if "and / or" or "and / or" appears throughout the text, its meaning includes three parallel scenarios. Taking "A and / or B" as an example, it includes scenario A, or scenario B, or the scenario where A and B are satisfied simultaneously. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on what can be achieved by those of ordinary skill in the art. When the combination of technical solutions results in contradictions or cannot be achieved, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0022] Please refer to Figure 1 and Figure 5 As shown, the present invention provides a blood glucose detection method. The blood glucose detection method is applied to a blood glucose detection device. The blood glucose detection device includes a sensor and a transmitter. The sensor and the transmitter can be detachably arranged. The steps of the blood glucose detection method include: S10, connecting the sensor and the transmitter, and the sensor and the transmitter perform information matching; S20, confirming that the information matching between the sensor and the transmitter is successful, and the sensor extracts the body tissue fluid of the person to be tested through anti-ion electroosmosis to obtain the glucose concentration value; S30, sending the glucose concentration value to the transmitter to obtain the target blood glucose value.

[0023] In this embodiment, the blood glucose detection device is a medical device capable of monitoring blood glucose levels. The blood glucose detection device can continuously and real-time detect the changes in the daily blood glucose of diabetic patients and record blood glucose data in real time. It is widely used in the daily blood glucose management of diabetic patients. Different from the traditional finger-pricking test, the sensor in the blood glucose detection device adheres to the skin to achieve continuous blood glucose detection.

[0024] Specifically, a blood glucose detection device generally includes a sensor and a transmitter. The sensor is usually attached to the human skin, such as the upper arm or abdomen, and glucose oxidase is provided inside the sensor. The glucose oxidase can react with glucose in the tissue fluid to measure the glucose concentration in the tissue fluid and convert the detected glucose concentration into an electrical signal. The transmitter is electrically connected to the sensor. The transmitter obtains the electrical signal regarding the glucose concentration in the sensor and simultaneously wirelessly transmits the obtained blood glucose data to an external mobile device or cloud device, such as a smartphone, a smartwatch, a dedicated monitor, a cloud server, etc., to facilitate the user to view data, analyze data, retrieve data, etc.

[0025] It can be understood that after the sensor is used for a long time, the glucose oxidase used to detect blood glucose in the sensor will gradually be exhausted, or the adhesive tape used to bond with the skin of the person to be tested in the sensor gradually loses its viscosity, and the adhesive force decreases, resulting in the sensor being unable to closely adhere to the skin for blood glucose detection, causing a decrease in detection accuracy.

[0026] That is to say, at this time, the sensor needs to be replaced. However, in traditional blood glucose detection devices, the sensor and the transmitter are of an integrated structure. For example, the sensor and the transmitter share the same packaging structure and the same circuit system. Replacing the sensor requires replacing the transmitter together, resulting in waste of the related structures and components of the transmitter and increasing the use cost of the blood glucose detection device. At the same time, the integrated structure of the transmitter and the sensor also makes the overall size of the blood glucose detection device relatively large, and the person to be tested has a strong sense of foreign body and discomfort during daily wearing, affecting the comfort and convenience of daily use.

[0027] Based on the above problems, the sensor and the transmitter in this blood glucose detection device are set as a separable structure, and the sensor and the transmitter are detachably connected. For example, a button is provided on the transmitter, and a buckle or a card slot and other structures are provided on the sensor corresponding to the button. When the user presses the button, the button can be connected to or separated from the buckle or the card slot.

[0028] By setting the sensor and the transmitter as two separable components, on the one hand, when the glucose oxidase inside the sensor is exhausted or the adhesive force with the skin decreases, only the sensor can be replaced while retaining the original transmitter to improve the recycling use of the transmitter and reduce the overall use cost of the blood glucose detection device. On the other hand, after the user attaches the sensor to the skin, the transmitter can be installed when blood glucose information needs to be obtained, and can be removed through a detachable structure such as a button when not needed, so as to reduce the load and discomfort caused by wearing and improve the comfort and convenience of use.

[0029] In this embodiment, the person to be tested first wears a sensor. For example, when the sensor is pasted on the skin or strapped to the arm or abdomen with an elastic band, then the transmitter is mechanically connected to the sensor, such as by magnetic attraction connection, snap connection, or bonding. And when the sensor and the transmitter are connected and after the connection is stable, information matching is performed. The sensor and the transmitter can use wireless communication technologies, such as NFC near-field communication, low-power Bluetooth communication, Wi-Fi, cellular network, Zigbee, etc., or conductive parts can be used to conduct the circuit to achieve data transmission and information matching. Of course, it can also be that wireless communication technology and circuit conduction are used simultaneously for information matching.

[0030] It can be understood that by matching the information of the sensor and the transmitter, the transmitter can directly perform device code recognition, identity matching, user information transmission, and detection information transmission with the sensor, and maintain the information connection between the sensor and the transmitter during detection, so as to form a complete blood glucose detection device in combination, thus eliminating the need for traditional information matching means such as scanning codes and authentication with the sensor and the transmitter respectively, effectively improving the pairing efficiency, simplifying the user usage process, reducing the complexity of user usage, and effectively shortening the pairing time of the sensor and the transmitter.

[0031] In this embodiment, after confirming that the information of the sensor and the transmitter is successfully matched, the sensor extracts the human tissue fluid of the person to be tested through counterion electroosmosis to obtain the glucose concentration value. Among them, after confirming that the information of the sensor and the transmitter is successfully matched, that is, when the blood glucose detection device is in the state where the sensor and the transmitter are connected, and the sensor can stably transmit electrical signals or data streams to the transmitter, the sensor extracts the human tissue fluid of the person to be tested through counterion electroosmosis to obtain the glucose concentration value in the human tissue fluid.

[0032] Specifically, the sensor is provided with an extraction electrode and a detection electrode. The extraction electrode includes an anode and a cathode. The anode and the cathode are respectively connected to the two poles of a constant current source. An electric field perpendicular to the skin surface is applied to the skin surface of the person to be tested through the extraction electrode. Under the action of the electric field, cations (such as Na+) in the subcutaneous tissue fluid of the skin migrate towards the cathode, and anions (Cl-) migrate towards the anode. Under physiological conditions, that is, when the skin surface is weakly alkaline (pH = 7.4), the skin surface is negatively charged, so that some neutral substances (such as glucose) in the subcutaneous layer of the skin approach the positive charge at the skin sensing area. That is, glucose and the like are more likely to migrate towards the cathode together with cations (Na+) and can penetrate through the skin and be extracted to the outside of the body.

[0033] At the same time, while limiting the electric field strength between the anode and the cathode to be as small as possible in terms of the skin stimulation of the person to be tested, it can also make as much glucose as possible transfer with the current. The electric field strength can be limited to be from 0.1 mA per square centimeter to 5 mA per square centimeter.

[0034] Among them, the material of the extraction electrode can be a gold, platinum, copper or carbon conductive electrode, and the surface of the extraction electrode is modified with a silver / silver chloride material, which is made by screen-printing silver / silver chloride on the surface of the conductive electrode or electroplating a layer of silver chloride on the silver electrode.

[0035] Furthermore, the detection electrode is a three-electrode system, and the detection electrode includes a working electrode, a counter electrode and a reference electrode. The surface of the working electrode is modified with glucose oxidase and an electron mediator compound. The electron mediator compound can be Prussian blue. Glucose oxidase can react with glucose in the tissue fluid to generate a glucose concentration value. The counter electrode forms a circuit with the working electrode, and the reference electrode is used to calibrate the working voltage in the working electrode.

[0036] It can be understood that after obtaining the glucose concentration value in the human tissue fluid, the sensor transmits the glucose concentration value to the transmitter in the form of a response electrical signal, and the transmitter re-calibrates and outputs the received glucose concentration value according to the regression model or the blood glucose neural network model to obtain a target blood glucose value closer to the glucose concentration in the blood of the person to be tested.

[0037] Furthermore, the regression model or the blood glucose neural network model can be established by comparing the relationship between the tissue fluid glucose concentration value and the blood glucose value of the experimental personnel. First, collect the human tissue fluid of the experimental personnel, and obtain the response current value of the glucose concentration value in the tissue fluid through the sensor. Then, use a blood glucose meter to measure the calibrated blood glucose value of the experimental personnel, and correspond the tissue fluid response current value and the calibrated blood glucose value of the experimental personnel one by one to obtain the regression model. After the subsequent sensor obtains the real-time tissue fluid glucose concentration value and inputs it into the regression model, the regression model can directly output the target blood glucose value in the human blood.

[0038] Of course, the blood glucose value of the human body is affected by multiple environmental factors at the same time, such as the collection time (morning, afternoon, evening, etc.), the age of the collector (youth, middle age, old age, etc.), the health status of the collector, etc. A blood glucose neural network model can be obtained by setting multi-parameter training on the basis of the one-to-one correspondence between the tissue fluid response current and the target blood glucose value.

[0039] Specifically, within different time periods, the blood glucose value of the experimental personnel will also fluctuate and change. For example, there will be large fluctuations during the two time periods of noon and evening. At the same time, the blood glucose in the body will also have large fluctuations before and after meals in a day. Therefore, the collection time can be introduced as a parameter into the blood glucose neural network model for training to ensure the accuracy of the blood glucose neural network model training and the accuracy of the output result.

[0040] Meanwhile, blood glucose levels vary among people of different ages and health statuses. For example, the natural blood glucose level of middle-aged and elderly people is higher than that of young people. Therefore, the identity information of the experimental subjects is introduced into the training of the blood glucose neural network model to ensure the accuracy of the training of the blood glucose neural network model and the accuracy of the output results.

[0041] The steps of the blood glucose detection method according to the technical solution of the present invention include: connecting a sensor and a transmitter, and performing information matching between the sensor and the transmitter; confirming that the information matching between the sensor and the transmitter is successful, and the sensor extracts the body tissue fluid of the person to be tested through anti-iontophoretic osmosis to obtain a glucose concentration value; sending the glucose concentration value to the transmitter to obtain a target blood glucose value. In this application, the blood glucose detection method is applied to a blood glucose detection device, which includes a sensor and a transmitter, and the sensor and the transmitter can be detachably arranged. When the person to be tested wears the sensor and installs and connects the transmitter to the sensor, the transmitter can directly perform information matching and pairing connection with the sensor, so as to avoid the user from performing information matching with the sensor and the transmitter separately at the same time, reduce the complexity of the pairing process, and improve the convenience of user use.

[0042] In one embodiment, as Figure 2 shown, the steps of connecting the sensor and the transmitter and performing information matching between the sensor and the transmitter include: S101, confirm that the sensor is in a worn state; S102, in the worn state, perform wireless authentication matching between the sensor and the transmitter to obtain the first matching information; S103, confirm that the sensor and the transmitter are in a connected state to obtain the second matching information; S104, confirm that the information matching between the sensor and the transmitter is successful according to the first matching information and the second matching information.

[0043] In this embodiment, the process of matching information between the sensor and the transmitter first needs to confirm that the sensor is in a worn state, that is, the sensor is in contact with the skin of the person to be tested. For example, a pressure sensor or an optical sensor is set on the side of the sensor that contacts the person to be tested to confirm that the sensor is in a worn state when the person to be tested wears the sensor. In the worn state, the sensor and the transmitter perform wireless authentication matching to obtain the first matching information. Specifically, the sensor end can be integrated with an NFC tag chip, and a helical antenna and a resonant capacitor matching circuit electrically connected to the NFC tag chip are provided. An NFC controller is provided at the transmitter end, and The NFC controller is independently powered. When the sensor and transmitter are close to each other, the NFC controller of the transmitter generates a 13.56MHz carrier. The antenna of the sensor obtains energy through electromagnetic induction and exchanges data. The first matching information obtained can be the device identification information between the sensor and the transmitter, or it can be the identity information and health information of the person to be tested, so as to verify the legitimacy of the equipment between the sensor and the transmitter, ensure the compatibility of the protocol versions of the sensor and the transmitter, and establish an encrypted channel to protect the privacy of medical data. Of course, the first matching information can be obtained once or continuously, which is not limited here.

[0044] Further, confirm that the sensor and the transmitter are in a connected state, that is, there is a stable mechanical connection between the sensor and the transmitter, such as being connected by snap-on, bonding, magnetic attraction, etc., and obtain second matching information between the sensor and the transmitter, wherein the second matching information can be continuously and uninterruptedly obtained after the sensor and the transmitter are connected to each other, or can be obtained at intervals. The second matching information includes but is not limited to biosignal data, such as the original electrochemical signal generated by the sensor, the impedance value of the tissue fluid, the skin temperature, the activity of glucose oxidase, the remaining life of the sensor, the transmitter battery voltage monitoring, etc.

[0045] It can be understood that by using NFC short-range wireless communication, it is possible to achieve the communication connection between the sensor and the transmitter and the data exchange between the sensor and the transmitter without any other operations by the person to be measured when the transmitter approaches or connects to the sensor, so as to realize the pairing and connection of the sensor and the transmitter. At the same time, on the basis of obtaining the first matching information through wireless authentication matching, the second matching information is obtained through the wired circuit conduction connection between the sensor and the transmitter, and the successful matching of the sensor and transmitter information is confirmed by the first matching information and the second matching information. On the one hand, it can improve the pairing and authentication efficiency of the connection between the sensor and the transmitter, reduce the complexity of the pairing process, and enhance the convenience of user use. On the other hand, the two-stage cross-authentication mechanism can also improve the reliability of the blood glucose detection device, realize the classification and multi-dimensional transmission authentication of different information, avoid problems such as large data volume and long authentication time caused by a single information matching channel, and further improve the pairing and authentication efficiency.

[0046] In one embodiment, the first matching information includes at least one of the following: The sensor device identity and the transmitter device identity; The first communication state between the sensor and the transmitter, where the first communication state includes connected and disconnected; The current first detection state of the sensor, where the first detection state includes timed detection, continuous detection, and stop detection.

[0047] It can be understood that the first matching information includes the device identity of the sensor itself and the device identity of the transmitter itself. The sensor device identity is the unique device code of the sensor, and the transmitter device identity is the unique device code of the transmitter. By obtaining the device identity of the transmitter through the sensor, or the device identity of the sensor through the transmitter, or the two-way transmission of their respective device identities between the sensor and the transmitter, the legitimacy of the device can be verified, avoiding the mutual access of incompatible transmitters (or transmitters and incompatible sensors), or avoiding cross-device mixing. At the same time, it ensures the compatibility of the software protocol versions of the sensor and the transmitter, and can also establish an encrypted channel to meet the requirements of medical data privacy.

[0048] Moreover, the first matching information may further include the first communication state between the sensor and the transmitter, where the first communication state includes the state of the sensor and the transmitter remaining connected and the disconnected state after the sensor and the transmitter are disconnected, to confirm the current connected state of the sensor and the transmitter. Finally, the first matching information may further include the current first detection state of the sensor. For timed detection, it can be started and enabled at regular intervals through programming or user-defined means, such as detecting once every 5 minutes for 1 - 2 minutes, or detecting once every 30 minutes for 5 - 10 minutes, etc., for daily health detection, which can effectively reduce the energy consumption of the blood glucose detection device and save detection resources on the sensor (such as glucose oxidase, etc.); continuous detection can be used in environments such as postoperative monitoring, daily monitoring of high-risk groups such as hyperglycemia or hypoglycemia, setting a higher sampling rate, such as 1 Hz, and transmitting the electrical signal value of glucose concentration from the sensor to the transmitter in real time; stop detection is to stop the information transmission between the sensor and the transmitter based on the lowest power consumption of the device in the standby state, thereby extending the battery life.

[0049] In one embodiment, the second matching information includes at least one of the following: The second communication state between the sensor and the transmitter, where the second communication state includes connected and disconnected; The current second detection state of the sensor, where the second detection state includes timed detection, continuous detection, and stop detection; The third communication state between the transmitter and an external electronic device, where the third communication state includes connected and disconnected; The sampling parameters of the sensor, where the sampling parameters include sampling current value, sampling frequency, sampling time, and range.

[0050] It can be understood that the second matching information and the first matching information can be obtained simultaneously through different dimensions and methods, or they can be obtained separately. For example, the first matching information is obtained through wireless authentication first, and then the second matching information is obtained through the conduction connection of the physical circuit. Or after the information matching process between the sensor and the transmitter is completed, only the second matching information is obtained and the acquisition of the first matching information is stopped to save the overall energy consumption of the blood glucose detection device.

[0051] Therefore, after the information matching between the sensor and the transmitter is completed, the acquisition of the first matching information between the sensor and the transmitter may stop, and only the second matching information is obtained through the conduction connection of the physical circuit. Based on this, the second matching information still includes, for example, the second communication state between the sensor and the transmitter, such as the connected state and the disconnected state, and the current second detection state of the sensor, where the second detection state still includes timed detection, continuous detection, and stop detection, etc., of the sensor.

[0052] Moreover, the second matching information obtained between the sensor and the transmitter further includes the third communication status between the transmitter and an external electronic device (such as an external mobile device or a cloud device that receives the target blood glucose value of the transmitter), so as to monitor the communication status between the transmitter and the external electronic device in real time, such as the connected status or the disconnected status, thereby ensuring that the transmitter can transmit the detection result of the sensor to the external device in real time, and ensuring that the person to be tested can monitor and view the current detection status in real time.

[0053] In one embodiment, as Figure 2 shown, after it is confirmed that the sensor and transmitter information match successfully according to the first matching information and the second matching information, when connecting the sensor and the transmitter, the steps of information matching between the sensor and the transmitter further include: S105, disconnect the wireless authentication matching between the sensor and the transmitter, and stop obtaining the first matching information; S106, keep the sensor and the transmitter in a connected state, and continuously obtain the second matching information.

[0054] In this embodiment, after it is confirmed that the sensor and the transmitter are successfully matched according to the first matching information and the second matching information, the blood glucose detection device disconnects the wireless authentication matching between the transmitter and the sensor, that is, disconnects their wireless communication connection. At this time, the first matching information is no longer obtained between the sensor and the transmitter, and on the basis of keeping the sensor and the transmitter in a physically conductive circuit connection, the second matching information is continuously obtained.

[0055] It can be understood that for wireless communication methods such as NFC near-field communication, continuous power supply is required during operation. Based on the above, the sensor and the transmitter can obtain the first matching information and the second matching information simultaneously or separately. After the information matching is completed, the wireless authentication matching can be disconnected to stop obtaining the first matching information, reducing the device power consumption of the transmitter and the sensor. At the same time, by continuously obtaining the second matching information through the physically conductive circuit connection, it can also ensure the continuous circuit conduction and monitoring of the sensor and the transmitter, ensure the normal information transmission between the sensor and the transmitter, and the real-time monitoring of the detection status of the sensor.

[0056] In one embodiment, as Figure 3 shown, after sending a target blood glucose electrical signal to the transmitter to obtain the target blood glucose value, the steps of the blood glucose detection method further include terminating the detection, and the steps of terminating the detection include: S401, detect that the circuit conduction between the sensor and the transmitter is interrupted, and the transmitter stops obtaining the second matching information; S402, enable the wireless authentication matching of the sensor and the transmitter, and re-obtain the first matching information; S403, the transmitter stores the first matching information, or sends the first matching information to the mobile terminal; S404, the sensor stops extracting the body tissue fluid of the person to be tested.

[0057] In this embodiment, the sensor and the transmitter are in a normal working state, that is, the sensor normally obtains the body tissue fluid of the person to be tested and maintains a good communication connection and a conductive circuit connection with the transmitter. At the same time, the transmitter can also convert the received glucose concentration value into a target blood glucose value in real time and stably. On the basis of the normal working state of the sensor and the transmitter, an abnormal interruption of the communication and conductive circuit between the transmitter and the sensor may occur due to the abnormal separation and detachment of the transmitter and / or the sensor, or the abnormal communication interruption between the transmitter and the external mobile terminal. At this time, the transmitter stops obtaining the second matching information, that is, there is no communication connection and conductive circuit connection between the transmitter and the sensor. Further, on the basis of stopping obtaining the second matching information, the wireless authentication matching of the sensor and the transmitter is re-enabled, and the transmitter re-obtains the first matching information of the sensor, that is, a normal communication connection between the sensor and the transmitter is maintained through near-field communication connection or other wireless connection methods.

[0058] It can be understood that, on the basis of detecting the interruption of the conductive circuit between the sensor and the transmitter and the transmitter stopping obtaining the second matching information, the wireless authentication matching of the transmitter and the sensor is re-enabled, and the transmitter and the sensor re-perform protocol authentication and pairing to obtain the current state of the sensor by re-obtaining the first matching information. When the sensor and the transmitter are within the range of near-field communication, the transmitter timely stores the first matching information, especially the data and information about the detected blood glucose, or timely sends the data and information about the blood glucose to the mobile terminal for display or storage, etc., to effectively ensure data security and avoid the loss of detected data due to emergencies such as the abnormal separation of the sensor and the transmitter or the abnormal interruption of the circuit.

[0059] Of course, when it is detected that the conductive circuit between the sensor and the transmitter is interrupted, it is also possible that the wireless authentication matching of the sensor and the transmitter cannot be activated, that is, at this time, neither the first matching information nor the second matching information can be obtained. At this time, the transmitter will quickly store the last received data or send it to the terminal device to ensure data security and avoid the loss of detected data.

[0060] At the same time, the sensor also stops extracting the tissue fluid of the person to be tested, avoiding the discomfort of the person to be tested caused by the long-term application of the detection voltage by the sensor, reducing the electrode loss and energy consumption, increasing the single-use duration, and preventing the data collected during the disconnection period from being lost or invalid due to inability to be transmitted.

[0061] Of course, terminating the detection may also include any of the following conditions: Obtain the response current value and confirm that the change rate of the response current value is less than 0.5% per minute; Obtain a third preset time and confirm that the third preset time is greater than 15 minutes; Obtain a blood glucose warning value and confirm that the target blood glucose value is greater than or equal to the blood glucose warning value; Disconnect the sensor from the transmitter; The person to be tested actively terminates the detection.

[0062] It can be understood that when the sensor continuously obtains the response current value in real time and detects that the minute change rate of the response current value is lower than 0.5% (for example, it drops from 100 nA / min to 99.5 nA / min), the system determines that the electrochemical system of the sensor fails. For example, there is insufficient interstitial fluid on the skin surface of the person to be tested, resulting in insufficient transfer of interstitial fluid to generate a response current signal, or the glucose oxidase provided on the detection electrode of the sensor is gradually exhausted and / or the enzyme activity decays, making the catalytic efficiency of glucose oxidase decrease, or the detection electrode of the sensor is passivated, forming an oxide layer on the detection electrode, increasing the impedance of the detection electrode and gradually reducing the acquisition of the response current value.

[0063] Or, obtain a third preset time. When it is confirmed that the sensor continuously detects for more than the third preset time, the blood glucose detection device terminates obtaining the blood glucose value. Among them, the third preset time can be within 15 minutes, such as 10 minutes, or greater than or equal to 15 minutes, such as 20 minutes, etc. The user can set it on a mobile terminal or in the cloud that is communicatively connected to the transmitter. When the sensor continuously detects for a certain period of time (such as the third preset time), the sensor will generate continuous electroosmotic stimulation on the skin of the person to be tested, thus causing discomfort and slight pain to the user. And the regeneration cycle of human interstitial fluid is once every 15 minutes to 20 minutes. Based on this, the detection can be terminated when the continuous detection exceeds the third preset time, and it can be restarted after an interval of time to leave time for the regeneration of interstitial fluid for the person to be tested, improving the comfort of use of the person to be tested. And, after the sensor continuously detects for a certain period of time (such as the third preset time) within the third preset time, the blood glucose value also tends to be stable and there is no need to continue the detection, so as to save detection resources (such as the power of the transmitter, the enzyme content and enzyme activity of glucose oxidase, the water content of the hydrogel on the electrode surface, etc.) and reduce the energy consumption of the blood glucose detection device.

[0064] Alternatively, preset and obtain a blood glucose warning value in advance. For example, a blood glucose warning value is set in an external mobile device or cloud that is communicatively connected to the transmitter. The blood glucose warning value is a blood glucose value that may be harmful to the user's physical health. When it is confirmed that the target blood glucose value is greater than or equal to the blood glucose warning value, the detection is terminated and an alarm is triggered to inform the person to be tested that they are in a relatively dangerous state. Among them, the blood glucose warning value can have three levels of alarms, and different warning methods can be used according to different blood glucose concentration values. For reaching a lower blood glucose warning value, such as 8 mmol / L to 13 mmol / L, vibration and short message prompts can be given, and the detection is terminated at the same time; for reaching a higher blood glucose warning value, such as 13 mmol / L to 18 mmol / L, sound and light alarms and short message prompts can be given, and the detection is terminated at the same time; for reaching a very high blood glucose warning value, such as greater than 18 mmol / L, emergency data can be pushed, and the detection is terminated to effectively remind the person to be tested of the high or low current target blood glucose value and help the person to be tested seek manual intervention in a timely manner, such as seeking medical treatment, injecting insulin, etc.

[0065] Alternatively, when the sensor and the transmitter are disconnected, such as when the contact impedance between the sensor and the transmitter mutates, or when the circuit between the surface sensor and the transmitter may be open-circuited when it conducts, the detection is terminated at this time. Or when the near-field communication signal between the sensor and the transmitter is lost, it also indicates that there is a problem with the signal transmission between the two, and the detection is also terminated to ensure that the sensor and the transmitter are in a stable communication connection state and circuit conduction state, and to ensure the stability of the data transmission of the target blood glucose value, as well as the accuracy and continuity of the detection.

[0066] Moreover, in the case where the user actively terminates the detection, the sensor can also stop detecting, and the transmission of electrical signals and data streams between the sensor and the transmitter stops.

[0067] In one embodiment, as Figure 4 shown, the sensor includes an extraction electrode and a detection electrode. After confirming that the information of the sensor and the transmitter matches successfully, the steps for the sensor to extract the body tissue fluid of the person to be tested by anti-ion electroosmosis and obtain the glucose concentration value include: S201, within a first preset time, the extraction electrode pre-extracts the body tissue fluid of the person to be tested to obtain a test response current value; S202, according to the test response current value, confirm that the blood glucose detection device is in a stable state; S203, within a second preset time, the extraction electrode obtains a tissue fluid sample of the person to be tested; S204, the detection electrode obtains the glucose concentration value in the tissue fluid according to the tissue fluid sample.

[0068] In this embodiment, during the process of obtaining the glucose concentration value, pre-extraction needs to be carried out first to confirm that the sensor and the blood glucose detection device are in a stable working state through pre-extraction within a period of time (within the first preset time, the first preset time can be from 1 minute to 10 minutes, such as 5 minutes, 6 minutes, 8 minutes, etc.). Also, when the blood glucose detection device is used for the first time and when it is reused after a long interval, pre-extraction will also be carried out to confirm that the blood glucose detection device is in a stable state. Among them, pre-extraction is to pre-extract the human tissue fluid of the person to be tested through the extraction electrode before officially obtaining the glucose concentration value to obtain the test response current value. The blood glucose detection device is pre-set with a standard response current value in a stable state. The current test response current value is compared with the standard response current value to confirm whether the current test response current value is normal and stable, so as to determine whether the blood glucose detection device is in a stable state.

[0069] It can be understood that during daily activities such as human movement and eating, blood glucose will fluctuate to a certain extent, resulting in fluctuations in the results when the sensor obtains the glucose concentration value. Relatively speaking, the glucose concentration value data obtained when the blood glucose value is stable will be more stable and accurate, and the accuracy of calibration calculation is better. Therefore, it is necessary to determine that the blood glucose detection device is in a stable state through pre-extraction, which can greatly improve the accuracy of the blood glucose value.

[0070] Moreover, by carrying out pre-extraction to determine that the blood glucose detection device is in a stable state, on the one hand, a part of the tissue fluid can be pre-extracted to the skin surface to remove epidermal pollutants and eliminate initial interference. On the other hand, it can also remove the passivation layer on the electrode surface to activate the electrode, so that the extraction electrode and the detection electrode of the sensor are in a good working state. At the same time, it can also calibrate the blood glucose detection device to ensure the accuracy and continuity of the detection results.

[0071] Furthermore, on the basis of confirming that the blood glucose detection device is in a stable state, a tissue fluid sample of the person to be tested is obtained through the extraction electrode within the second preset time. The sensor is provided with an extraction electrode and a detection electrode. The extraction electrode includes an anode and a cathode. The anode and the cathode are respectively connected to the two poles of a constant current source. An electric field perpendicular to the skin surface is applied to the skin surface of the person to be tested through the extraction electrode. Under the action of the electric field, cations (such as Na+) in the subcutaneous tissue fluid migrate towards the cathode, and anions (Cl-) migrate towards the anode. Under physiological conditions, that is, when the skin surface is weakly alkaline (pH = 7.4), the skin surface is negatively charged, so that some neutral substances (such as glucose) in the subcutaneous layer approach the positive charge at the skin sensing part, that is, glucose and the like are more likely to migrate towards the cathode together with cations (Na+), and can penetrate through the skin and be extracted to the outside of the body.

[0072] Meanwhile, while limiting the electric field strength between the anode and the cathode to be as small as possible in terms of skin irritation to the person to be measured, as much glucose as possible can be transferred with the current. The electric field strength can be limited to be from 0.1 mA per square centimeter to 5 mA per square centimeter.

[0073] Among them, the material of the extraction electrode can be a gold, platinum, copper or carbon conductive electrode, and the surface of the extraction electrode is modified with a silver / silver chloride material, which is made by screen-printing silver / silver chloride on the surface of the conductive electrode or electroplating a layer of silver chloride on the silver electrode.

[0074] Furthermore, the detection electrode is a three-electrode system. The detection electrode includes a working electrode, a counter electrode and a reference electrode. Among them, the surface of the working electrode is modified with glucose oxidase and an electron mediator compound. The electron mediator compound can be Prussian blue. Glucose oxidase can react with glucose in the tissue fluid to generate a glucose concentration value. The counter electrode forms a circuit with the working electrode, and the reference electrode is used to calibrate the working voltage in the working electrode.

[0075] In one embodiment, as Figure 4 shown, after the detection electrode obtains the glucose concentration value in the tissue fluid according to the tissue fluid sample, the steps of obtaining the glucose concentration value further include: S205, obtaining a historical stable glucose concentration value; S206, comparing the current glucose concentration value with the historical stable glucose concentration value to confirm whether the current glucose concentration value is in a stable range; S2061, if so, sending the current glucose concentration value to the transmitter to obtain the target blood glucose value; S2062, if not, discarding the abnormal value in the current glucose concentration value, re-obtaining the glucose concentration value, and again confirming whether the current glucose concentration value is in a stable range.

[0076] In this embodiment, as the wearing time of the sensor increases, the medium of the electrochemical reaction will gradually be depleted. For example, the glucose oxidase provided on the surface of the detection electrode is gradually exhausted, and the loss of the water in the hydrogel provided on the surface of the detection electrode leads to a decrease in the microcurrent transmission efficiency, and the intensity and stability of the microcurrent also gradually weaken. Or, in scenarios such as after the person to be measured exercises or eats, the glucose concentration value detected by the sensor may also be in an unstable state, such as the glucose concentration value suddenly increases or suddenly decreases to generate abnormal data, etc.

[0077] Based on the above problems, after obtaining the glucose concentration value, the present application compares the current glucose concentration value with the historical stable glucose concentration value and corrects the current glucose concentration value to avoid large deviations in the glucose concentration value. Specifically, the historical stable glucose concentration value is stored in a blood glucose detection device, or an external mobile device communicatively connected to the blood glucose detection device, or an external cloud server communicatively connected to the blood glucose detection device, etc. The historical stable glucose concentration value stores verified reliable data, and the historical stable glucose concentration value reflects the stable and accurate blood glucose values obtained during a specific past detection time. By comparing the current glucose concentration value with the historical stable glucose concentration value, it is confirmed whether the currently detected glucose concentration value is within a stable range.

[0078] Further, if the currently detected glucose concentration value is within the stable range, the current glucose concentration value is sent to the transmitter, and the target blood glucose value related to the current glucose concentration value is obtained through the transmitter. If the currently detected glucose concentration value is not within the stable range, the abnormal values in the detected glucose concentration value are discarded, such as larger and smaller glucose concentration values, and the same number of glucose concentration values as those discarded are newly obtained. Again, it is confirmed whether the current glucose concentration value is within the stable range through the newly obtained glucose concentration values.

[0079] It can be understood that by confirming whether the current glucose concentration value is within the stable range, the abnormal data in the obtained glucose concentration value can be eliminated, and it is ensured that the obtained glucose concentration value is generally within a stable and accurate detection range, ensuring the stability, continuity, and accuracy of the overall detection.

[0080] The present invention also proposes a blood glucose detection device, which includes a sensor and the above-mentioned transmitter. The sensor is provided with a first conductive member, and the transmitter is provided with a second conductive member. The transmitter is detachably connected to the sensor. The blood glucose detection device has a connection state in which the sensor and the transmitter are connected. In the connection state, the first conductive member and the second conductive member are in contact and the circuit is conducted. It can be understood that by setting the sensor and the transmitter as two separable components, on the one hand, when the glucose oxidase inside the sensor is exhausted or the adhesion force to the skin decreases, only the sensor can be replaced while retaining the original transmitter to improve the recycling of the transmitter and reduce the overall use cost of the blood glucose detection device. On the other hand, after the user attaches the sensor to the skin, the transmitter can be installed when blood glucose information is needed and removed through a detachable structure such as a button when not needed, so as to reduce the load and discomfort caused by wearing and improve the comfort and convenience of use.

[0081] The computer-readable storage medium provided by the present invention stores computer-readable program instructions for executing the above blood glucose detection method. The computer-readable program instructions are used to execute the blood glucose detection method in the above embodiments, and solve the technical problems of complex pairing process and low convenience between the existing transmitter and sensor. Compared with the prior art, the beneficial effects of the computer-readable storage medium provided by the embodiments of the present invention are the same as those of the blood glucose detection method provided by the above embodiments, and will not be elaborated here.

[0082] The computer-readable storage medium provided by the embodiments of the present invention may be, for example, a USB flash drive, but is not limited to electrical, magnetic, optical, electromagnetic, infrared, or semiconductor systems, devices or components, or any combination of the above. More specific examples of the computer-readable storage medium may include, but are not limited to: electrical connections with one or more wires, portable computer disks, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fibers, portable compact disk read-only memory (CD-ROM), optical storage devices, magnetic storage devices, or any suitable combination of the above. In this embodiment, the computer-readable storage medium may be any tangible medium that contains or stores a program, and the program can be used by or in combination with an instruction execution system, device or component. The program code contained on the computer-readable storage medium can be transmitted by any suitable medium, including but not limited to: wires, optical cables, RF (radio frequency), etc., or any suitable combination of the above.

[0083] The above computer-readable storage medium may be included in an electronic device; or may exist separately without being assembled into the electronic device.

[0084] Computer program code for performing the operations of the present disclosure may be written in one or more programming languages or combinations thereof. The above programming languages include object-oriented programming languages - such as Java, Smalltalk, C++, and also include conventional procedural programming languages - such as the "C" language or similar programming languages. The program code may be executed entirely on the user's computer, partially on the user's computer, executed as a stand-alone software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server.

[0085] In the case of a remote computer, the remote computer can be connected to the user's computer through any type of network - including a local area network (LAN) or a wide area network (WAN) - or can be connected to an external computer (for example, by using an Internet service provider to connect through the Internet).

[0086] The modules involved in the embodiments of the present disclosure can be implemented in software or in hardware. In some cases, the name of the module does not constitute a limitation on the unit itself.

[0087] The above are only exemplary embodiments of the present invention, and do not limit the patent scope of the present invention. Any equivalent structural transformation made by using the content of the specification and drawings of the present invention under the technical concept of the present invention, or any direct / indirect application in other related technical fields, is included in the patent protection scope of the present invention.

Claims

1. A blood glucose detection method, which is applied to a blood glucose detection device. The blood glucose detection device includes a sensor and a transmitter, and the sensor and the transmitter are detachably arranged. It is characterized in that, The steps of the blood glucose detection method include: Connect the sensor and the transmitter, and the sensor and the transmitter perform information matching; Confirm that the information matching between the sensor and the transmitter is successful. The sensor extracts the human tissue fluid of the person to be tested through counterion electroosmosis to obtain the glucose concentration value; Send the glucose concentration value to the transmitter to obtain the target blood glucose value.

2. The blood glucose detection method according to claim 1, wherein The step of connecting the sensor and the transmitter, and the sensor and the transmitter performing information matching includes: Confirm that the sensor is in a worn state; In the worn state, the sensor and the transmitter perform wireless authentication matching to obtain the first matching information; Confirm that the sensor and the transmitter are in a connected state to obtain the second matching information; Confirm that the information matching between the sensor and the transmitter is successful according to the first matching information and the second matching information.

3. The blood glucose detection method according to claim 2, wherein The first matching information includes at least one of the following: The sensor device identity identifier and the transmitter device identity identifier; The first communication state between the sensor and the transmitter, and the first communication state includes connected and disconnected; The current first detection state of the sensor, and the first detection state includes timed detection, continuous detection, and stop detection.

4. The blood glucose detection method according to claim 2, wherein The second matching information includes at least one of the following: The second communication state between the sensor and the transmitter, and the second communication state includes connected and disconnected; The current second detection state of the sensor, and the second detection state includes timed detection, continuous detection, and stop detection; The third communication state between the transmitter and the external electronic device, and the third communication state includes connected and disconnected; The sampling parameters of the sensor, and the sampling parameters include sampling current value, sampling frequency, sampling time, and range.

5. The blood glucose detection method according to claim 2, wherein After confirming that the information matching between the sensor and the transmitter is successful according to the first matching information and the second matching information, the step of connecting the sensor and the transmitter, and the sensor and the transmitter performing information matching further includes: Disconnect the wireless authentication matching between the sensor and the transmitter and stop obtaining the first matching information; Keep the sensor and the transmitter in a connected state and continuously obtain the second matching information.

6. The blood glucose detection method according to claim 5, wherein, After sending the target blood glucose electrical signal to the transmitter to obtain the target blood glucose value, the steps of the blood glucose detection method further include terminating the detection, and the steps of terminating the detection include: Detect that the circuit conduction between the sensor and the transmitter is interrupted, and the transmitter stops obtaining the second matching information; Enable the wireless authentication matching between the sensor and the transmitter to re-obtain the first matching information; The transmitter stores the first matching information or sends the first matching information to the mobile terminal; The sensor stops extracting the human tissue fluid of the person to be tested.

7. The blood glucose detection method according to any one of claims 1 to 6, characterized in that The sensor includes an extraction electrode and a detection electrode. The step of confirming that the information matching between the sensor and the transmitter is successful, and the sensor extracting the human tissue fluid of the person to be tested through counterion electroosmosis to obtain the glucose concentration value includes: Within a first preset time, the extraction electrode pre-extracts human tissue fluid of the person to be tested to obtain a test response current value; Confirming that the blood sugar detection device is in a stable state according to the test response current value; Within the second preset time, the extraction electrode obtains a tissue fluid sample from the person to be tested; The detection electrode obtains the glucose concentration value in the tissue fluid according to the tissue fluid sample.

8. The blood glucose detection method according to claim 7, wherein After the detection electrode obtains the glucose concentration value in the tissue fluid according to the tissue fluid sample, the step of obtaining the glucose concentration value further includes: Obtain historical stable glucose concentration values; Comparing the current glucose concentration value with the historical stable glucose concentration value to confirm whether the current glucose concentration value is in a stable range; If yes, sending the current glucose concentration value to the transmitter to obtain a target blood glucose value; If not, the abnormal value in the current glucose concentration value is discarded, the glucose concentration value is acquired again, and it is confirmed again whether the current glucose concentration value is in a stable range.

9. A blood glucose detection device, which applies the blood glucose detection method according to any one of claims 1 to 8, characterized in that, The blood sugar detection device comprises: A sensor having a first conductive member; and A transmitter, wherein the transmitter is detachably connected to the sensor, and the transmitter is provided with a second conductive member. The blood glucose detection device has a connection state in which the sensor and the transmitter are connected. In the connection state, the first conductive member and the second conductive member are in contact and the circuit is turned on.

10. A storage medium, characterized in that, The storage medium is a computer-readable storage medium, and a computer program is stored on the storage medium. When the computer program is executed by a processor, the steps of the blood glucose detection method according to any one of claims 1 to 8 are implemented.

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