Multi-channel sample parallel detection device of liquid phase chip instrument

Abstract

The invention discloses a multichannel sample parallel detection device of a liquid phase chip instrument, and relates to the field of detection devices.The multichannel sample parallel detection device comprises a liquid phase chip instrument main body, a pretreatment chamber is arranged in the liquid phase chip instrument main body, a pore plate box and a sample loading device are arranged in the pretreatment chamber, a lifting plate is arranged at the bottom end of the pore plate box, and a sample loading device is arranged at the bottom end of the lifting plate; a driving assembly and a lifting assembly are arranged at the bottom end of the lifting plate, the lifting assembly comprises a lifting rod, moving rods are fixedly mounted on the two sides of the lifting rod, the guide grooves are fixedly mounted at the bottom end of the inner wall of the pretreatment chamber, and each guide groove is divided into a straight low-position section, a straight high-position section and an inclined lifting section. According to the invention, through cooperation of the driving assembly, sample adding of the test tube is realized in a multi-channel sample parallel manner, the detection speed is greatly increased, the manual error is reduced, meanwhile, through arrangement of the lifting assembly, the situation that liquid splashes to the inner wall of the test tube when a reagent is dropwise added by the sample adding device is reduced, and the accuracy of a detection result is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of detection devices, and particularly to a multi-channel sample parallel detection device for a liquid-phase chip analyzer. Background Art

[0002] As a cutting-edge device in the field of life science and medical detection, the liquid-phase chip analyzer is an innovative high-throughput detection platform that combines flow cytometry and microsphere suspension array technology. It uses different fluorescent-coded microspheres with specific capture probes on their surfaces to specifically react with the sample to be tested, and then uses a laser to excite the fluorescent substances on the microspheres. By detecting the fluorescent signals, rapid quantitative analysis of multiple target molecules (such as biomarkers such as antigens, nucleic acids, proteins, etc.) in a single well can be achieved. Compared with traditional detection technologies, this device not only greatly improves the detection efficiency, but also significantly reduces the sample consumption, and has important application value in the fields of clinical diagnosis, drug research and development, disease screening, etc.

[0003] In the prior art, to meet the needs of large-scale sample detection, existing liquid-phase chip analyzers are often equipped with multi-channel sample parallel detection devices. Through an integrated design, this device can process dozens to hundreds of samples simultaneously, effectively coping with batch sample analysis tasks in scenarios such as high-throughput screening, epidemiological investigations, and drug clinical trials. However, the current multi-channel sample parallel detection device still has problems in the sample pretreatment link. Before the test tube enters the formal detection process, operations such as sample addition and shaking and mixing need to be completed in sequence. If the manual single-sample-by-sample addition method is used, it not only takes time and effort, resulting in low overall detection efficiency, but also the sample processing process is cumbersome, prone to introducing human operation errors, and it is difficult to ensure the accuracy and repeatability of the detection results. In addition, manual operation may also increase the risk of cross-contamination, further affecting the detection accuracy, and cannot meet the requirements of modern high-throughput detection for timeliness, standardization, and automation. Summary of the Invention

[0004] The main object of the present invention is to propose a multi-channel sample parallel detection device for a liquid-phase chip analyzer, aiming to solve the problems in the existing multi-channel sample parallel detection device for a liquid-phase chip analyzer, such as low detection efficiency, complex sample processing process, and difficult to guarantee detection accuracy due to manual single-sample-by-sample addition.

[0005] To solve the above problems, the present invention proposes a multi-channel sample parallel detection device for a liquid-phase chip analyzer, including a main body of the liquid-phase chip analyzer. Inside the main body of the liquid-phase chip analyzer, there is a pretreatment chamber. Inside the pretreatment chamber, there are a well plate box and a sample loading device. The top of the well plate box is evenly provided with holes for placing test tubes. The bottom of the well plate box is provided with a lifting plate. The well plate box and the lifting plate are connected by an adjusting component. The bottom of the lifting plate is provided with a driving component for transporting the well plate box to the bottom of the sample loading device and a lifting component for bringing the test tubes in the well plate box closer to the sample loading device. One side of the lifting plate is provided with a measuring component for judging the initial horizontal position of the well plate box. The lifting component includes lifting rods arranged at the bottom of the lifting plate. On both sides of each lifting rod, there are fixedly installed moving rods. The moving rods are all slidably installed on the inner wall of the guiding groove. The guiding grooves are all fixedly installed at the bottom of the inner wall of the pretreatment chamber. The guiding grooves are each divided into a straight low-level section and a high-level section, and an inclined lifting section. The low-level section and the high-level section are both connected by the lifting section.

[0006] Preferably, the driving component includes a first driving plate arranged below the lifting plate. The first driving plate is slidably installed on the outer wall of the lifting rod. A first lead screw is threadedly installed on the inner wall of one side of the first driving plate. One end of the first lead screw is connected to a motor. The motor is connected to an external power supply through a wire. A first guiding rod is slidably installed on the inner wall of the other side of the first driving plate away from the first lead screw. On the other side of the first driving plate, there is a positioning component for keeping the test tube vertical.

[0007] Preferably, the measuring component includes a first abutting block arranged on one side of the lifting plate. The bottom of the first abutting block abuts against a positioning block. One side of the positioning block is fixedly installed with a first connecting plate. The bottom of the first connecting plate is fixedly installed with a first connecting rod. The other end of the first connecting rod is fixedly installed with a placing seat. The bottom of the placing seat is fixedly installed with a first sliding plate. The first sliding plate is slidably installed on the inner wall of the first sealing cavity. The first sealing cavity is fixedly installed inside the pretreatment chamber. One side of the first sealing cavity is fixedly installed with a second sealing cavity. The first sealing cavity and the second sealing cavity are connected by a connecting channel. A second sliding block is slidably installed on the inner wall of the second sealing cavity.

[0008] Preferably, the adjusting component includes an adjusting plate arranged between the well plate box and the lifting plate. The adjusting plate is fixedly installed at the bottom of the well plate box. A second lead screw is threadedly installed on the inner wall of one corner of the adjusting plate. The bottom of the second lead screw passes through the lifting plate and is fixedly installed with an adjusting turning handle. Second guiding rods are slidably installed on the inner walls of the other three corners of the adjusting plate. The second guiding rods are all fixedly installed at the top of the lifting plate.

[0009] Preferably, the positioning component includes a second driving plate fixedly installed on one side of the first driving plate. A driving groove is formed on one side of the second driving plate. A second abutting block abuts against the inner wall of the driving groove. A second connecting plate is arranged on one side of the second abutting block. Several pressing plates are fixedly installed at the bottom end of the second connecting plate. The several pressing plates are connected by a second connecting rod. A first limiting rod is slidably installed inside the second connecting rod. The first limiting rod is fixedly installed inside the top end of the orifice plate box. First centering blocks are uniformly installed on one side of each pressing plate. Second centering blocks are arranged on one side of each first centering block. The second centering blocks are fixedly installed on one side of the holes.

[0010] Preferably, one end of the second abutting block close to the driving groove is set as an inclined part. The top end of the inclined part is set as an inclined surface. The bottom end of the inclined part is set as a flat surface. The cross-section of the driving groove is set to be the same as that of the second abutting block.

[0011] Preferably, the distance between the top end of the second driving plate and the driving groove is greater than the distance between the horizontal height of the high position section and the horizontal height of the low position section of the guiding groove.

[0012] Preferably, a sliding groove is formed inside the second connecting plate. The second abutting block is slidably installed on the inner wall of the sliding groove. A third guiding rod is fixedly installed on one side of the second abutting block close to the sliding groove. A resilient spring is sleeved on the outer wall of the third guiding rod.

[0013] Preferably, a second limiting rod is fixedly installed on one side of the second abutting block. The second limiting rod is slidably installed on the inner wall of the limiting groove. The limiting groove is formed inside the second connecting plate.

[0014] Preferably, a dismounting hole is arranged on one side of the second limiting rod. The dismounting hole is formed on one side of the second connecting plate.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: Through the cooperation of the driving component and the sample loading device, the technical solution of the present invention enables the sample addition of the test tube to use multi-channel sample parallelism, realizes automated process operation, greatly improves the detection speed and reduces human error. At the same time, by setting the lifting component and the adjusting component, the situation that the liquid splashes onto the inner wall of the test tube when the sample loading device drops the reagent is reduced, thereby improving the accuracy and stability of the detection result. Description of the Drawings

[0016] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0017] Figure 1 is a schematic diagram of the overall structure of the liquid-phase chip instrument of the present invention; Figure 2 is a schematic cross-sectional structure diagram at the pretreatment chamber of the present invention; Figure 3 is a schematic cross-sectional structure diagram of the lifting assembly of the present invention; Figure 4 is the present invention Figure 3 an enlarged view of part A in; Figure 5 is a schematic structure diagram at the orifice plate box of the present invention; Figure 6 is the present invention Figure 5 an enlarged view of part B in; Figure 7 is a schematic cross-sectional structure diagram at the second connecting plate of the present invention; Figure 8 is a schematic structure diagram at the measurement assembly of the present invention; Figure 9 is a schematic cross-sectional structure diagram of the measurement assembly of the present invention from another perspective.

[0018] The description of the reference numerals is as follows: 1. Main body of the liquid-phase chip instrument; 2. Pretreatment chamber; 3. Orifice plate box; 4. Lifting plate; 5. Sampling device; 6. Lifting rod; 7. Moving rod; 8. Guide groove; 9. First driving plate; 10. First lead screw; 11. Motor; 12. First abutting block; 13. Positioning block; 14. First connecting plate; 15. First connecting rod; 16. Placing seat; 17. First sliding plate; 18. First sealing cavity; 19. Second sealing cavity; 20. Connection channel; 21. Second sliding block; 22. Adjusting plate; 23. Second lead screw; 24. Adjusting turning handle; 25. Second driving plate; 26. Driving groove; 27. Second abutting block; 28. Second connecting plate; 29. Extrusion plate; 30. Second connecting rod; 31. First limiting rod; 32. First centering block; 33. Second centering block; 34. Chute; 35. Third guiding rod; 36. Elastic spring; 37. Second limiting rod; 38. Limiting groove; 39. Disassembly hole. Detailed implementation manners

[0019] The technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts belong to the scope of protection of the present invention.

[0020] In the present invention, unless otherwise clearly defined and limited, terms such as "connection" and "fixation" shall be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0021] The present invention provides a multi-channel sample parallel detection device for a liquid phase chip analyzer. The multi-channel sample parallel detection device of the liquid phase chip analyzer cooperates with a driving component and a sample loading device 5, so that the sample addition of the test tube also uses the multi-channel sample parallel method, realizing an automated process operation, greatly improving the detection speed and reducing human error. At the same time, by setting a lifting component and an adjusting component, the situation where liquid splashes onto the inner wall of the test tube when the sample loading device 5 drops the reagent is reduced, thereby improving the accuracy and stability of the detection result.

[0022] Embodiment 1 In this embodiment, the structure of a multi-channel sample parallel detection device for a liquid phase chip analyzer is as Figures 1 to 9 shown, including a liquid phase chip analyzer main body 1. Inside the liquid phase chip analyzer main body 1, a pretreatment chamber 2 is provided. Inside the pretreatment chamber 2, a well plate box 3 and a sample loading device 5 are provided. The top of the well plate box 3 is evenly provided with holes for placing test tubes. Among them, the sample loading device 5 is provided with a dropping syringe and a lateral moving device. The number of dropping syringes is the same as the number of holes in a row on the well plate box 3. Through the lateral moving device, the dropping syringes can add samples to the test tubes placed on the well plate box 3 row by row, improving the sample addition accuracy and working efficiency at the same time. A lifting plate 4 is provided at the bottom of the well plate box 3. The well plate box 3 and the lifting plate 4 are connected through an adjusting component. At the bottom of the lifting plate 4, a driving component for transporting the well plate box 3 to the bottom of the sample loading device 5 and a lifting component for bringing the test tubes in the well plate box 3 close to the sample loading device 5 are provided. A measuring component for judging the initial horizontal position of the well plate box 3 is provided on one side of the lifting plate 4. Among them, as Figures 2 to 4As shown in the figure, the driving component includes a first driving plate 9 arranged below the lifting plate 4. The first driving plate 9 is slidably installed on the outer wall of the lifting rod 6. A first lead screw 10 is threadedly installed on the inner wall of one side of the first driving plate 9. One end of the first lead screw 10 is connected to a motor 11. The motor 11 is connected to an external power supply through a wire. A first guide rod is slidably installed on the inner wall of the side of the first driving plate 9 away from the first lead screw 10. A positioning component for keeping the test tube vertical is arranged on the other side of the first driving plate 9. After the staff places the test tube in the hole of the top of the orifice plate box 3, the motor 11 can be started (in this embodiment, the model of the motor 11 is selected as LW100, and since the motor 11 belongs to mature prior art, its internal structure and working principle will not be described in detail). The motor 11 drives the orifice plate box 3 to move through the first lead screw 10, the first driving plate 9, the lifting rod 6 and the lifting plate 4, so that the orifice plate box 3 moves to the bottom of the sample loading device 5, realizing accurate positioning of the orifice plate box 3 during sample loading. Compared with manual operation, the position of the orifice plate box 3 is more accurate, which can reduce the disorder degree of the reagent falling into the orifice plate box 3 and reduce the generation of water splashes, thereby improving the mixing degree of the reagent and the sample and improving the detection result. The lifting component includes a lifting rod 6 arranged at the bottom end of the lifting plate 4. Moving rods 7 are fixedly installed on both sides of the lifting rod 6. The moving rods 7 are slidably installed on the inner walls of the guide grooves 8. The guide grooves 8 are fixedly installed at the bottom end of the inner wall of the pretreatment chamber 2. The guide grooves 8 are divided into a flat low-level section, a high-level section and an inclined lifting section. The low-level section and the high-level section are connected by the lifting section. With such a design, when the driving component drives the test tube in the orifice plate box 3 to move, the first driving plate 9 drives the lifting rod 6 to move, so that the lifting rod 6 drives the moving rod 7 to move. Then, due to the limiting and guiding effect of the guide groove 8 on the moving rod 7, the moving rod 7 moves along the inner track of the guide groove 8. The inclined lifting section design of the guide groove 8 can drive the moving rod 7 to move from the low-level section to the high-level section, so as to drive the test tube to lift through the lifting rod 6, the lifting plate 4 and the orifice plate box 3, making the orifice plate box 3 closer to the dropping syringe on the sample loading device 5, reducing the impact force when the reagent enters the test tube under the action of gravity, further reducing the generation of water splashes, and improving the accuracy of the detection result. In the prior art, the samples detected by the liquid phase chip analyzer need to be manually dropped with reagents one by one, which has problems such as low detection efficiency, complex sample processing process and difficult to guarantee detection accuracy. By adopting the design of the driving component and the sample loading device 5 in this embodiment, multi-channel sample simultaneous loading can be carried out on the test tubes in the orifice plate box 3, greatly improving the detection speed and reducing manual errors. At the same time, a lifting component is also set, reducing the situation that liquid splashes onto the inner wall of the test tube when the sample loading device 5 drops the reagent, thereby improving the accuracy and stability of the detection result.

[0023] Embodiment 2 For further supplementary explanation on the basis of Embodiment 1, in this embodiment, as Figure 3 、Figure 7 and Figure 8 As shown in Figure 8 , the measuring assembly includes a first abutting block 12 disposed on one side of the lifting plate 4. The bottom end of the first abutting block 12 abuts against a positioning block 13. A first connecting plate 14 is fixedly installed on one side of the positioning block 13. The bottom end of the first connecting plate 14 is fixedly installed with a first connecting rod 15. The other end of the first connecting rod 15 is fixedly installed with a placing seat 16. The bottom end of the placing seat 16 is fixedly installed with a first sliding plate 17. The first sliding plate 17 is slidably installed on the inner wall of the first sealing cavity 18. The first sealing cavity 18 is fixedly installed in the pretreatment chamber 2. A second sealing cavity 19 is fixedly installed on one side of the first sealing cavity 18. The first sealing cavity 18 and the second sealing cavity 19 are connected through a connecting channel 20. A second sliding block 21 is slidably installed on the inner wall of the second sealing cavity 19. It should be noted that the weight of the second sliding block 21 is set to M, and the sum of the weights of the placing seat 16 and the first sliding plate 17 is set to m1, such that M is equal to m1 + m2. Since the volume of the solvent in the test tube often accounts for three-quarters of the test tube capacity, m2 is set to the sum of the weights of the test tube and the solvent with a volume of three-quarters of the test tube capacity. With such a design, before sample addition, a staff member can place a test tube to be sampled on the placing seat 16. At this time, the pressure on the first sealing cavity 18 changes due to the pressure of the first sliding plate 17. Denote the sum of the gravity of the test tube and the solvent in the test tube at this time as m. If m is greater than m2, the first sliding plate 17 compresses the volume of the gas in the first sealing cavity 18, resulting in an increase in the air pressure on the side of the first sealing cavity 18, pushing the second sliding block 21 to move upward, increasing the volume in the second sealing cavity 19 and enhancing the air pressure. When the air pressures in the first sealing cavity 18 and the second sealing cavity 19 are equal, the first sliding plate 17 and the second sliding block 21 regain force balance. At this time, the first sliding plate 17 drives the positioning block 13 to move through the placing seat 16, the first connecting rod 15, and the first connecting plate 14. If m is less than m2, the force on the top end of the first sliding plate 17 decreases, causing the gas inside the first sealing cavity 18 to push the first sliding plate 17 to move. At this time, the volume inside the first sealing cavity 18 increases and the air pressure decreases, causing the gas in the second sealing cavity 19 to move into the first sealing cavity 18, increasing the air pressure in the first sealing cavity 18 and decreasing the air pressure in the second sealing cavity 19. When the air pressures in the first sealing cavity 18 and the second sealing cavity 19 are equal, the first sliding plate 17 and the second sliding block 21 regain force balance. At this time, the first sliding plate 17 drives the positioning block 13 to move through the placing seat 16, the first connecting rod 15, and the first connecting plate 14. It should be noted that according to the ideal gas law, it can be deduced that the movement amount of the positioning block 13 , where V0 is the total gas volume in the first sealing cavity 18, the second sealing cavity 19 and the connecting channel 20, and A is the cross-sectional area of the first slide plate 17. Since the sum of the weights of the test tube and the solvent in the test tube, m, is much smaller than the sum of the weights of the placement seat 16 and the first slide plate 17, m1, there is an approximately linear relationship between ∆h and m. Thus, relatively precise measurement and position control can be achieved within a short range of changes. If more precise measurement and positioning are required, in other embodiments, a pressure sensor can also be provided at the bottom end of the placement seat 16, and a positioning component can be provided at the bottom end of the positioning block 13. The positioning component can be composed of a lifting motor, a lifting lead screw, and a lifting slider. The size of m can be accurately measured by the pressure sensor, and a signal can be sent according to the actual size of m to control the start of the lifting component, thereby driving the positioning block 13 to move an appropriate distance. In addition, in this embodiment, the gas in the first sealing cavity 18, the second sealing cavity 19, and the connecting channel 20 is preferably nitrogen, which is close to an ideal gas under normal temperature and pressure, conforms to the PV = nRT law, is convenient for accurately calculating the changes in air pressure and volume through the state equation, ensures the stability of the cover plate movement, and has chemical inertness, does not react with the materials in the device (such as metals, plastics), avoids gas deterioration or corrosion of the cavity, and is especially suitable for scenarios involving biological samples (such as liquid phase chip analyzers); Further, the adjusting component includes an adjusting plate 22 disposed between the orifice plate box 3 and the lifting plate 4. The adjusting plate 22 is fixedly installed at the bottom end of the orifice plate box 3. A second lead screw 23 is threadedly installed on the inner wall of one corner of the adjusting plate 22. The bottom end of the second lead screw 23 passes through the lifting plate 4 and is fixedly installed with an adjusting handle 24. Second guide rods are slidably installed on the inner walls of the other three corners of the adjusting plate 22, and the second guide rods are fixedly installed at the top end of the lifting plate 4. By cooperating the adjusting component with the measuring component, after the position of the positioning block 13 in the measuring component tends to be stable, the staff can rotate the adjusting handle 24, so that the adjusting handle 24 drives the adjusting plate 22 to move through the second lead screw 23, and the adjusting plate 22 drives the first abutting block 12 to move to abut against the positioning block 13, thereby adjusting the initial horizontal position of the test tube in the orifice plate box 3. Since the volumes of different samples in the test tube are different, for example, for general samples, while ensuring that the solvent in the tube does not splash out of the test tube during vibration and ensuring the accuracy of the detection data, the solvent in the tube often accounts for two-thirds of the volume of the test tube, while for biological samples, it shall not exceed one-half. At this time, when adding samples to biological samples at the dropping positions of conventional samples, it is easy for the reagent to splash onto the inner wall of the test tube when contacting the solvent, reducing the mixing effect of the solvent and the reagent, and thus affecting the detection result. After adopting the adjusting component in this embodiment, during subsequent sample addition, the distance between the test tube and the dropping syringe can be kept appropriate, further improving the accuracy of reagent dropping, reducing the impact force during reagent dropping, thereby improving the mixing degree of the reagent and the solvent, and improving the accuracy of the detection result.

[0024] Embodiment Three In this embodiment, as Figures 3 to 7As shown in the figure, the positioning component includes a second driving plate 25 fixedly installed on one side of the first driving plate 9. A driving groove 26 is formed on one side of the second driving plate 25. The inner wall of the driving groove 26 abuts against a second abutting block 27. A second connecting plate 28 is arranged on one side of the second abutting block 27. One end of the second abutting block 27 close to the driving groove 26 is set as an inclined part. The top end of the inclined part is set as an inclined surface, and the bottom end of the inclined part is set as a flat surface. The cross-section of the driving groove 26 is set to be the same as that of the second abutting block 27. With such a design, when the lifting component drives the lifting plate 4 to lift, the lifting plate 4 drives the second abutting block 27 to move through the orifice plate box 3. Since the first driving plate 9 does not move in the vertical direction, the second driving plate 25 moves downward relative to the second abutting block 27. Through the setting of the inclined surface, the vertical thrust of the driving groove 26 on the second abutting block 27 is decomposed into a horizontal thrust, thereby pushing the driving groove 26 to move in the direction close to the second connecting plate 28, so that the driving groove 26 can drive the second connecting plate 28 to move. A plurality of pressing plates 29 are fixedly installed at the bottom end of the second connecting plate 28. The plurality of pressing plates 29 are connected by a second connecting rod 30. A first limiting rod 31 is slidably installed on the inner wall of the second connecting rod 30. The first limiting rod 31 is fixedly installed on the inner side of the top end of the orifice plate box 3. First centering blocks 32 are uniformly installed on one side of each pressing plate 29. Second centering blocks 33 are arranged on one side of each first centering block 32. The second centering blocks 33 are all fixedly installed on one side of the hole. With such a design, when the second abutting block 27 pushes the second connecting plate 28 to move, the second connecting plate 28 drives the first centering blocks 32 to move in the direction close to the test tube through the pressing plates 29 and the second connecting rod 30, so that the first centering blocks 32 and the second centering blocks 33 center and position the test tube. To facilitate the staff to place the test tube, the diameter of the hole at the top of the orifice plate box 3 is often larger than the diameter of the test tube, which may cause the test tube to easily shift. Furthermore, when adding samples, the reagent is likely to fall on the inner wall of the test tube, resulting in part of the reagent remaining on the inner wall of the test tube, making the reagent content in the solvent less than the dropping amount and affecting the test result. However, through the positioning component, the sample addition can be more accurate, thereby improving the accuracy of the test result. In addition, it should be added that the distance between the top end of the second driving plate 25 and the driving groove 26 is greater than the distance between the horizontal height of the high position section and the horizontal height of the low position section of the guiding groove 8. With such a design, it can be avoided that when the moving rod 7 moves to the high position section of the guiding groove 8, the moving rod 7 drives the second abutting block 27 to move through the lifting rod 6, the lifting plate 4, the orifice plate box 3 and the second connecting plate 28. If the distance between the top end of the second driving plate 25 and the driving groove 26 is less than the distance between the horizontal height of the high position section and the horizontal height of the low position section of the guiding groove 8, then at this time, the second abutting block 27 moves to the top end of the second driving plate 25, and one side of the second driving plate 25 no longer abuts against the second abutting block 27, resulting in insufficient squeezing force of the first centering block 32 on the test tube, and the test tube is likely to shift under the action of inertia.Problems leading to a decrease in the accuracy of sample addition.

[0025] Furthermore, a chute 34 is provided on the inner wall of the second connecting plate 28. The second abutting block 27 is slidably mounted on the inner wall of the chute 34. A third guiding rod 35 is fixedly installed on the side of the second abutting block 27 close to the chute 34. An elastic spring 36 is sleeved on the outer wall of the third guiding rod 35. With this design, when the first aligning block 32 tightly abuts against one side of the test tube, the second driving plate 25 continues to lift. At this time, when the second driving plate 25 drives the second abutting block 27 to move in the direction close to the second connecting plate 28 through the driving groove 26, the second abutting block 27 can slide in the chute 34 and accumulate elastic potential energy for buffering by squeezing the elastic spring 36, so as to avoid the problem that the first aligning block 32 and the second aligning block 33 apply too much pressure to the test tube, resulting in the test tube being easily damaged, the sample being contaminated, affecting the test results, or even causing the test tube to break and contaminating the equipment. In addition, by providing the third guiding rod 35, on the one hand, it can provide a limiting and guiding effect on the movement of the second abutting block 27, making the movement of the second abutting block 27 smoother and more stable. On the other hand, it can provide a protection effect on the elastic spring 36 when the elastic spring 36 undergoes elastic deformation, avoiding the problem that the elastic spring 36 is prone to bending deformation during the elastic deformation process, shortening the service life of the elastic spring 36.

[0026] Furthermore, in this embodiment, as Figures 5 to 7 shown, a second limiting rod 37 is fixedly installed on one side of the second abutting block 27. The second limiting rod 37 is slidably mounted on the inner wall of the limiting groove 38. The limiting groove 38 is provided on the inner side of the second connecting plate 28. With this design, the movement trajectory of the second abutting block 27 can be limited by the limitation of the second limiting rod 37 by the limiting groove 38, avoiding the problem that the second abutting block 27 moves out of the chute 34 due to the elastic action of the elastic spring 36 and affecting the subsequent operation. Furthermore, a disassembly hole 39 is provided on one side of the second limiting rod 37. The disassembly hole 39 is provided on one side of the second connecting plate 28. A clamping block is also installed in the disassembly hole 39. The second limiting rod 37 is slidably mounted on one side of the second abutting block 27. The second limiting rod 37 and the second abutting block 27 are connected by a spring. With this design, when the elastic spring 36 is used for a long time and its elasticity decays, the staff can insert a slender tool such as a punch into the disassembly hole 39 and press the second limiting rod 37 into the second abutting block 27. At this time, the staff can easily take out the second abutting block 27 and replace the elastic spring 36.

[0027] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structural transformation made under the inventive concept of the present invention by using the content of the specification and drawings of the present invention, or any direct / indirect application in other related technical fields is included in the patent protection scope of the present invention.

Claims

1. A multi-channel sample parallel detection device for a liquid phase chip analyzer, comprising a liquid phase chip analyzer main body (1), characterized in that, Inside the main body (1) of the liquid-phase chip instrument, a pretreatment chamber (2) is provided. Inside the pretreatment chamber (2), a well plate box (3) and a sample loading device (5) are provided. The top of the well plate box (3) is evenly provided with holes for placing test tubes. The bottom of the well plate box (3) is provided with a lifting plate (4). The well plate box (3) and the lifting plate (4) are connected by an adjustment assembly. The bottom of the lifting plate (4) is provided with a driving assembly for transporting the well plate box (3) to the bottom of the sample loading device (5) and a lifting assembly for bringing the test tubes in the well plate box (3) closer to the sample loading device (5). One side of the lifting plate (4) is provided with a measuring assembly for judging the initial horizontal position of the well plate box (3). The lifting assembly includes lifting rods (6) arranged at the bottom of the lifting plate (4). Moving rods (7) are fixedly installed on both sides of the lifting rods (6). The moving rods (7) are all slidably installed on the inner walls of the guiding grooves (8). The guiding grooves (8) are all fixedly installed at the bottom of the inner wall of the pretreatment chamber (2). The guiding grooves (8) are all divided into a straight low-level section and a high-level section, and an inclined lifting section. The low-level section and the high-level section are both connected by the lifting section.

2. The multi-channel sample parallel detection device of a liquid-phase chip instrument according to claim 1, wherein, The driving assembly includes a first driving plate (9) arranged below the lifting plate (4). The first driving plate (9) is slidably installed on the outer wall of the lifting rod (6). A first lead screw (10) is threadedly installed on the inner wall of one side of the first driving plate (9). One end of the first lead screw (10) is connected to a motor (11). The motor (11) is connected to an external power supply through a wire. A first guiding rod is slidably installed on the inner wall of the other side of the first driving plate (9) away from the first lead screw (10). A positioning assembly for keeping the test tube vertical is arranged on the other side of the first driving plate (9).

3. The multi-channel sample parallel detection device of a liquid-phase chip instrument according to claim 1, characterized in that, The measuring assembly includes a first abutting block (12) arranged on one side of the lifting plate (4). The bottom of the first abutting block (12) abuts against a positioning block (13). A first connecting plate (14) is fixedly installed on one side of the positioning block (13). A first connecting rod (15) is fixedly installed at the bottom of the first connecting plate (14). The other end of the first connecting rod (15) is fixedly installed with a placing seat (16). A first sliding plate (17) is fixedly installed at the bottom of the placing seat (16). The first sliding plate (17) is slidably installed on the inner wall of the first sealing cavity (18). The first sealing cavity (18) is fixedly installed inside the pretreatment chamber (2). A second sealing cavity (19) is fixedly installed on one side of the first sealing cavity (18). The first sealing cavity (18) and the second sealing cavity (19) are connected through a connecting channel (20). A second sliding block (21) is slidably installed on the inner wall of the second sealing cavity (19).

4. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 1, characterized in that, The adjusting assembly includes an adjusting plate (22) disposed between the orifice plate box (3) and the lifting plate (4). The adjusting plate (22) is fixedly installed at the bottom end of the orifice plate box (3). A second lead screw (23) is threadedly installed on the inner wall of one corner of the adjusting plate (22). The bottom end of the second lead screw (23) passes through the lifting plate (4) and is fixedly installed with an adjusting turning handle (24). Second guide rods are slidably installed on the inner walls of the other three corners of the adjusting plate (22), and the second guide rods are fixedly installed at the top end of the lifting plate (4).

5. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 2, wherein, The positioning assembly includes a second driving plate (25) fixedly installed on one side of the first driving plate (9). A driving groove (26) is formed on one side of the second driving plate (25). A second abutting block (27) abuts against the inner wall of the driving groove (26). A second connecting plate (28) is disposed on one side of the second abutting block (27). Several pressing plates (29) are fixedly installed at the bottom end of the second connecting plate (28). The several pressing plates (29) are connected by a second connecting rod (30). A first limiting rod (31) is slidably installed in the inner wall of the second connecting rod (30), and the first limiting rod (31) is fixedly installed inside the top end of the orifice plate box (3). First straightening blocks (32) are uniformly installed on one side of the pressing plate (29), and second straightening blocks (33) are disposed on one side of each first straightening block (32), and the second straightening blocks (33) are fixedly installed on one side of the hole.

6. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 5, characterized in that, One end of the second abutting block (27) close to the driving groove (26) is provided with an inclined portion. The top end of the inclined portion is provided with an inclined surface, and the bottom end of the inclined portion is provided with a flat straight surface. The cross section of the driving groove (26) is set to be the same as the cross section of the second abutting block (27).

7. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 5, wherein, The distance between the top end of the second driving plate (25) and the driving groove (26) is greater than the distance between the horizontal height of the high position section and the horizontal height of the low position section of the guide groove (8).

8. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 5, characterized in that, A sliding groove (34) is formed in the inner wall of the second connecting plate (28). The second abutting block (27) is slidably installed in the inner wall of the sliding groove (34). A third guide rod (35) is fixedly installed on one side of the second abutting block (27) close to the sliding groove (34), and a resilient spring (36) is sleeved on the outer wall of the third guide rod (35).

9. The multi-channel sample parallel detection device of a liquid-phase chip instrument according to claim 5, wherein A second limiting rod (37) is fixedly installed on one side of the second abutting block (27), and the second limiting rod (37) is slidably installed in the inner wall of the limiting groove (38), and the limiting groove (38) is formed inside the second connecting plate (28).

10. The multi-channel sample parallel detection device of a liquid phase chip instrument according to claim 9, characterized in that, One side of the second limiting rod (37) is provided with a disassembly hole (39), and the disassembly hole (39) is formed on one side of the second connecting plate (28).

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