Column pipe system and generator

Abstract

The invention discloses a column tube system and a generator, the column tube system comprises a chromatographic column, an elastic plug and a bracket, and two openings are respectively formed in two axial ends of the chromatographic column; the two elastic plugs are respectively connected with two ends of the chromatographic column and are used for sealing an opening of the chromatographic column; the support comprises a first supporting leg, two limiting plates arranged at intervals in the first direction are arranged on the first supporting leg, the color layer column and the two elastic plugs are located between the two limiting plates, and the two elastic plugs abut against the two limiting plates respectively. According to the column pipe system disclosed by the invention, the bracket is arranged, and the two limiting plates are arranged on the bracket at an interval, so that when the color layer column is mounted, the color layer column is clamped between the two limiting plates, and the elastic plugs at the two ends of the color layer column are respectively propped against the two limiting plates, so that the color layer column is extruded and limited by the limiting plates at the two ends; the installation stability of the chromatographic column in the production process is improved, and the liquid leakage probability is reduced.

Description

Technical Field

[0001] This application belongs to the field of automated production, and particularly relates to a column tube system and a generator. Background Art

[0002] A radioactive isotope generator can provide carrier-free, high specific activity, and high radioactive concentration short-lived nuclides for people multiple times safely and conveniently, so it is widely used in the fields of medicine, industry, scientific research, etc. The short-lived nuclides obtained from a radioactive isotope generator can be directly applied or made into various labeled compounds (including drugs) for application.

[0003] In related technologies, the column tube system of a generator is divided into two categories. One is a rigid pipeline, which is easy to realize automated production, but the pipeline sealing plug is easy to slip off, with a risk of radioactive leakage. The other is a flexible pipeline, which cannot complete automation and has a slow production speed.

[0004] In actual production, it is difficult for the column tube system of a generator to meet the requirements of automated production, high production efficiency, and low radioactive leakage risk. Summary of the Invention

[0005] The embodiments of this application provide a column tube system and a generator. The chromatographic column facilitates automatic fixation and self-fastening during the production process of the generator, so as to improve production efficiency, ensure the stability and consistency of the structure, reduce connection errors caused by manual operation, and reduce labor intensity and production costs.

[0006] An embodiment of the first aspect of this application provides a column tube system, including a chromatographic column, an elastic plug, and a bracket. The chromatographic column is provided with two openings at both ends in its axial direction; the two elastic plugs are respectively connected to both ends of the chromatographic column for sealing the openings of the chromatographic column; the bracket includes a first leg, and two limiting plates are arranged on the first leg at intervals along a first direction. The chromatographic column and the two elastic plugs are both located between the two limiting plates, and the two elastic plugs respectively abut against the two limiting plates.

[0007] According to the implementation manner of the first aspect of this application, it further includes an infusion tube and an outflow tube. The infusion tube and the outflow tube are respectively connected to an elastic plug and are both communicated with the chromatographic column. The infusion tube is used to convey materials into the chromatographic column, and the outflow tube is used to discharge the materials in the chromatographic column.

[0008] According to the implementation manner of the first aspect of this application, the bracket further includes two second legs. The two second legs are both connected to the first leg. The second leg includes a second support plate and a second groove formed by enclosing the second support plate. At least part of the infusion tube and at least part of the outflow tube are respectively located in the second grooves of the two second legs.

[0009] According to an embodiment of the first aspect of the present application, two second legs are located on the same side of the first leg in the first direction; the bracket further includes a mounting plate, which is located on the side of the second legs away from the first leg and is connected to both second legs. The mounting plate is provided with a perfusion through-hole and an outflow through-hole that penetrate in the first direction. The perfusion through-hole is communicated with a perfusion pipe, and the outflow through-hole is communicated with an outflow pipe.

[0010] According to an embodiment of the first aspect of the present application, it further includes: a perfusion needle assembly, including a first needle seat and a perfusion needle tube connected to the first needle seat. The first needle seat is connected to the mounting plate, so that the perfusion needle tube is communicated with the perfusion pipe through the perfusion through-hole; an outflow needle assembly, including a second needle seat and an outflow needle tube connected to the second needle seat. The second needle seat is connected to the mounting plate, so that the outflow needle tube is communicated with the outflow pipe through the outflow through-hole.

[0011] According to an embodiment of the first aspect of the present application, a plurality of first limiting pieces protrude from the side of the mounting plate away from the first leg. A part of the first limiting pieces surrounds the perfusion through-hole, and another part of the first limiting pieces surrounds the outflow through-hole. A limiting groove is formed between two adjacent first limiting pieces; at least one second limiting piece protrudes from both the first needle seat and the second needle seat. When the second limiting piece of the first needle seat extends into any one of the limiting grooves, the first needle seat is connected to the mounting plate. When the second limiting piece of the second needle seat extends into any one of the limiting grooves, the second needle seat is connected to the mounting plate.

[0012] According to an embodiment of the first aspect of the present application, the mounting plate is further provided with an avoidance hole that penetrates in the first direction, and the avoidance hole is located between the perfusion through-hole and the outflow through-hole.

[0013] According to an embodiment of the first aspect of the present application, the first leg includes a first support plate and a first groove and a third groove formed by enclosing the first support plate. The first groove is located between the limiting plates, and at least part of the chromatographic column is located in the first groove; the outflow pipe includes a first section and a second section arranged in sequence. At least part of the first section is located in the third groove. At least part of the second section is located in the second groove.

[0014] According to an embodiment of the first aspect of the present application, one end of the first section away from the second section extends out of the third groove and is connected to an elastic plug.

[0015] An embodiment of the first aspect of the present application provides a generator, including a reaction tank and the column tube system of any of the above embodiments. A sealed cavity is provided in the reaction tank, and the chromatographic column is located in the sealed cavity.

[0016] The column tube system of the present application is provided with a bracket, and two spaced limiting plates are arranged on the bracket. When installing the chromatographic column, the chromatographic column is clamped between the two limiting plates, and the elastic plugs at both ends of the chromatographic column are respectively abutted against the two limiting plates, so that the chromatographic column is squeezed and limited by the limiting plates at both ends, improving the installation stability of the chromatographic column during the production process and reducing the probability of liquid leakage. By making the chromatographic column only be clamped by the limiting plates on both sides during installation, the disassembly and assembly speed of the chromatographic column is increased, the manual operation steps are reduced, the labor intensity and operation difficulty of workers are reduced, workers are protected from radioactive ray irradiation, and the production speed is increased. By providing a bracket for installing the chromatographic column, the dimensional consistency of multiple installations of the chromatographic column is improved, the errors that may be caused by manual operation are avoided, and thus the installation accuracy of the chromatographic column is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings required to be used in the embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0018] Figure 1 Front view structural schematic diagram of the column tube system of some embodiments of the present application;

[0019] Figure 2 Front view structural schematic diagram showing an example bracket;

[0020] Figure 3 Front view structural schematic diagram showing an example chromatographic column and elastic plug;

[0021] Figure 4 Front view structural schematic diagram showing an example chromatographic column, elastic plug, perfusion tube and outflow tube;

[0022] Figure 5 Top view structural schematic diagram showing an example bracket;

[0023] Figure 6 Side view structural schematic diagram showing an example column tube system;

[0024] Figure 7 Cross-sectional view structural schematic diagram showing an example generator;

[0025] Figure 8 Exploded view structural schematic diagram showing an example generator.

[0026] REFERENCE MARKS:

[0027] 10, column tube system; 20, reaction tank; 21, sealing cavity; 30, sealing plug; 40, cover body; 50, handle; 60, outer shell;

[0028] 100, chromatographic column

[0029] 200, elastic plug;

[0030] 300, bracket; 310, first leg; 311, limiting plate; 312, first support plate; 313, first groove; 314, third groove; 315, second clamping part; 320, second leg; 321, second support plate; 322, second groove; 323, first clamping part; 330, mounting plate; 331, perfusion through-hole; 332, outflow through-hole; 333, first limiting piece; 334, limiting groove; 335, avoidance hole; 336, mounting hole;

[0031] 400, perfusion tube;

[0032] 500, outflow tube; 510, first section; 520, second section;

[0033] 600, connecting piece;

[0034] 700, perfusion needle assembly; 710, first needle seat; 711, second limiting piece; 720, perfusion needle tube;

[0035] 800, outflow needle assembly; 810, second needle seat; 820, outflow needle tube; 830, filter element;

[0036] x, first direction. Detailed implementation manners

[0037] The features and exemplary embodiments of various aspects of the present application will be described in detail below. In order to make the purpose, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present application, rather than limiting the present application. For those skilled in the art, the present application can be implemented without some of these specific details. The following description of the embodiments is only intended to provide a better understanding of the present application by showing examples of the present application.

[0038] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising..." does not exclude the presence of additional identical elements in the process, method, article or device comprising said element.

[0039] To solve the technical problems involved in the background art, the applicant provides a column tube system, which includes a chromatographic column, an elastic plug and a bracket. The chromatographic column is provided with two openings at both ends in its axial direction; two elastic plugs are respectively connected to both ends of the chromatographic column for sealing the openings of the chromatographic column; the bracket includes a first leg, and two limiting plates are arranged on the first leg at intervals in a first direction. The chromatographic column and the two elastic plugs are both located between the two limiting plates, and the two elastic plugs are respectively abutted against the two limiting plates.

[0040] In the column tube system of the present application, by providing a bracket with two spaced-apart limiting plates, when installing the chromatographic column, the chromatographic column is clamped between the two limiting plates, and the elastic plugs at both ends of the chromatographic column are respectively abutted against the two limiting plates, so that the chromatographic column is squeezed and limited by the limiting plates at both ends, improving the installation stability of the chromatographic column during the production process and reducing the probability of liquid leakage. By making the chromatographic column only be clamped by the limiting plates on both sides during installation, the disassembly and assembly speed of the chromatographic column is increased, the manual operation steps are reduced, the labor intensity and operation difficulty of workers are reduced, workers are protected from radioactive ray irradiation, and the production speed is increased. By providing a bracket for installing the chromatographic column, the dimensional consistency of the chromatographic column during multiple installations is improved, avoiding errors that may be caused by manual operation, and thus improving the installation accuracy of the chromatographic column.

[0041] The column tube system provided by the embodiments of the present application will be introduced below with reference to the accompanying drawings. In the drawings, for the convenience of drawing, the dimensions in the drawings do not necessarily have a proportional relationship with the actual dimensions.

[0042] Please refer to Figures 1 to 3 , Figure 1 which is a front view structural schematic diagram of the column tube system of some embodiments of the present application; Figure 2 showing a front view structural schematic diagram of an exemplary bracket; Figure 3 showing a front view structural schematic diagram of an exemplary chromatographic column and an elastic plug.

[0043] As Figures 1 to 3As shown in the figure, the present application provides a column tube system 10, which includes a chromatographic column 100, an elastic plug 200 and a bracket 300. The chromatographic column 100 is provided with two openings (not shown) at both ends in its axial direction. The two elastic plugs 200 are respectively connected to both ends of the chromatographic column 100 to seal the openings of the chromatographic column 100. The bracket 300 includes a first leg 310, and two limiting plates 311 are arranged on the first leg 310 at intervals along the first direction (the x direction in the figure). The chromatographic column 100 and the two elastic plugs 200 are both located between the two limiting plates 311, and the two elastic plugs 200 are respectively abutted against the two limiting plates 311.

[0044] Optionally, the distance between the two limiting plates 311 in the first direction x is greater than the length of the chromatographic column 100 and less than the total installation length of the chromatographic column 100 and the two elastic plugs 200. When the chromatographic column 100 is clamped between the two limiting plates 311, the elastic plug 200 will be squeezed by the two limiting plates 311 and undergo a certain elastic deformation, which can improve the installation stability of the chromatographic column 100 and at the same time reduce the probability of leakage caused by the elastic plug 200 detaching from the chromatographic column 100.

[0045] Optionally, the bracket 300 has certain wear-resistant and corrosion-resistant properties. The elastic plug 200 has corrosion-resistant and highly elastic properties. It should be noted that any elastic and corrosion-resistant material is within the protection scope of this embodiment, such as polymer materials such as polyurethane and polysiloxane. Those skilled in the art can select appropriate materials as the elastic plug 200 according to the actual use situation. The chromatographic column 100 can be a glass column.

[0046] Optionally, the sealing of the opening of the chromatographic column 100 by the elastic plug 200 can include one or a combination of rubber plug aluminum cover crimping seal, sealing ring elastic seal, and threaded sealing ring end face seal.

[0047] The column tube system 10 of the present application, by providing a bracket 300 with two spaced-apart limiting plates 311 thereon, when installing the chromatographic column 100, the chromatographic column 100 is clamped between the two limiting plates 311, and the elastic plugs 200 at both ends of the chromatographic column 100 are respectively abutted against the two limiting plates 311, so that the chromatographic column 100 is squeezed and limited by the limiting plates 311 at both ends, improving the installation stability of the chromatographic column 100 during the production process and reducing the probability of liquid leakage. By enabling the chromatographic column 100 to be only clamped by the limiting plates 311 on both sides during installation, the disassembly and assembly speed of the chromatographic column 100 is increased, the manual operation steps are reduced, the labor intensity and operation difficulty of workers are reduced, the workers are protected from radioactive ray irradiation, and the production speed is increased. By providing a bracket 300 for installing the chromatographic column 100, the dimensional consistency of multiple installations of the chromatographic column 100 is improved, the errors that may be brought by manual operation are avoided, and thus the installation accuracy of the chromatographic column 100 is improved. The column tube system of the present application is compatible with hard pipelines and soft pipelines, can adapt to various complex pipeline layouts and space limitations, and can be more conveniently installed and adjusted in cooperation with the bracket.

[0048] Please refer to Figures 1 to 4 , Figure 4 which shows a front view structural schematic diagram of an exemplary chromatographic column, elastic plug, perfusion tube and outflow tube.

[0049] As Figures 1 to 4 shown, in some embodiments, the column tube system 10 further includes a perfusion tube 400 and an outflow tube 500. The perfusion tube 400 and the outflow tube 500 are respectively connected to an elastic plug 200 and are both communicated with the chromatographic column 100. The perfusion tube 400 is used to convey materials into the chromatographic column 100, and the outflow tube 500 is used to discharge the materials in the chromatographic column 100.

[0050] Optionally, the elastic plug 200 is provided with through holes (not shown) for fixing the perfusion tube 400 and the outflow tube 500. The perfusion tube 400 and the outflow tube 500 respectively extend into the through holes of the two elastic plugs 200 and are fixedly connected to the elastic plug 200, thereby realizing the communication between the perfusion tube 400 and the outflow tube 500 and the chromatographic column 100. Among them, the perfusion tube 400, the outflow tube 500 and the elastic plug 200 can be connected by processes such as welding, gluing, and clamping.

[0051] Optionally, the chromatographic column 100 is filled with an adsorbent. The perfusion tube 400 is used to perfusion a sodium chloride elution solution into the chromatographic column 100, and the outflow tube 500 is used to discharge the radioactive reaction solution. Among them, the elastic plug 200 connected to the perfusion tube 400 is located above the chromatographic column 100, and the elastic plug 200 connected to the outflow tube 500 is located below the chromatographic column 100.

[0052] Optionally, the perfusion tube 400 and the outflow tube 500 can be rigid pipelines or flexible pipelines. In this embodiment, it is exemplified that both the perfusion tube 400 and the outflow tube 500 are flexible hoses.

[0053] Optionally, through holes (not shown) through which the perfusion tube 400 and the outflow tube 500 can pass are provided on the limiting plate 311, so that the perfusion tube 400 and the outflow tube 500 can pass through the through holes and be connected to the elastic plug 200.

[0054] In the column tube system 10 of the present application, by making both the perfusion tube 400 and the outflow tube 500 be flexible hoses, the hoses have the following advantages: 1) High flexibility, capable of adapting to various complex pipeline layouts and space limitations; 2) Can effectively absorb vibration and shock, reduce mechanical stress on the bracket 300 and the chromatographic column 100, and extend the service life of the equipment; 3) Easier to operate and install compared to rigid pipes, facilitating maintenance and repair. By making both the perfusion tube 400 and the outflow tube 500 be connected to the elastic plug 200, when the elastic plug 200 and the chromatographic column 100 are clamped on the bracket 300, the elastic plug 200 can also play a certain role in assisting the positioning of the perfusion tube 400 and the outflow tube 500. By making through holes through which the perfusion tube 400 and the outflow tube 500 can pass be provided on the limiting plate 311, when the perfusion tube 400 and the outflow tube 500 are connected to the elastic plug 200, the through holes on the limiting plate 311 can also play a certain role in assisting the positioning of the perfusion tube 400 and the outflow tube 500.

[0055] In some alternative embodiments, the bracket 300 further includes two second legs 320, and both of the two second legs 320 are connected to the first leg 310. The second leg 320 includes a second support plate 321 and a second groove 322 formed by enclosing the second support plate 321. At least part of the perfusion tube 400 and at least part of the outflow tube 500 are respectively located in the second grooves 322 of the two second legs 320.

[0056] Optionally, the two second legs 320 are located on the same side of the first leg in the first direction, and the two second legs 320 and the first leg 310 together form a Y shape.

[0057] Optionally, as Figure 2 shown, the second groove 322 is formed by partially enclosing the second support plate 321, that is, the second support plate 321 is a semi-circular arc-shaped plate.

[0058] In another embodiment, the second groove 322 can be formed by completely surrounding and enclosing the second support plate 321, that is, the second support plate 321 is a sleeve, and the perfusion tube 400 and the outflow tube 500 can extend into the sleeve from one end opening of the sleeve.

[0059] Optionally, the second leg 320 further includes a first clamping member 323. The first clamping member 323 is connected to the second support plate 321 and is located on the side of the second support plate 321 facing the second groove 322. The first clamping member 323 is used to fix the perfusion tube 400 or the outflow tube 500 located in the second groove 322. Since both the perfusion tube 400 and the outflow tube 500 are flexible hoses, the perfusion tube 400 and the outflow tube 500 can be conveniently snapped into the first clamping member 323 to achieve the fixed connection between the perfusion tube 400, the outflow tube 500 and the second leg 320.

[0060] For the column tube system 10 of the present application, by providing two second legs 320 for installing the perfusion tube 400 and the outflow tube 500, the dimensional consistency of multiple installations of the perfusion tube 400 and the outflow tube 500 is improved, the errors that may be brought by manual operation are avoided, and thus the installation accuracy of the perfusion tube 400 and the outflow tube 500 is improved. By providing the first clamping member 323 for fixing the perfusion tube 400 and the outflow tube 500, the disassembly and assembly speed of the perfusion tube 400 and the outflow tube 500 is increased, the manual operation steps are reduced, and the labor intensity and operation difficulty of workers are reduced.

[0061] In some alternative embodiments, the first leg 310 includes a first support plate 312 and a first groove 313 and a third groove 314 formed by enclosing the first support plate 312. The first groove 313 is located between the two limiting plates 311, and at least part of the chromatographic column 100 is located in the first groove 313. The outflow tube 500 includes a first section 510 and a second section 520 arranged in sequence. At least part of the first section 510 is located in the third groove 314, and at least part of the second section 520 is located in the second groove 322.

[0062] Optionally, both the first groove 313 and the third groove 314 extend along the first direction x.

[0063] Optionally, the extending directions of the first groove 313 and the third groove 314 intersect with the first direction x.

[0064] Optionally, as Figure 2 shown, the first groove 313 and the third groove 314 are partially formed by enclosing the second support plate 321, that is, the second support plate 321 is two semicircular arc plates arranged side by side, respectively used to accommodate the chromatographic column 100 and the outflow tube 500.

[0065] In another embodiment, the third groove 314 can be completely surrounded and formed by the first support plate 312, that is, a part of the first support plate 312 is a sleeve, and the first section 510 can extend into the sleeve from one end opening of the sleeve.

[0066] Optionally, one end of the first section 510 facing away from the second section 520 extends out of the third groove 314 and is connected to the elastic plug 200.

[0067] Optionally, the first leg 310 further includes a second engaging member 315. The second engaging member 315 is connected to the first support plate 312 and is located on the side of the first support plate 312 facing the third groove 314. The second engaging member 315 is used to fix the first section 510 located in the third groove 314. Since the outflow pipe 500 is a flexible pipe, the first section 510 of the outflow pipe 500 can be conveniently snapped into the second engaging member 315 to realize the fixed connection between the first section 510 and the first leg 310.

[0068] In the column tube system 10 of the present application, by providing the second engaging member 315 for the first section 510 of the outflow pipe 500, the disassembly and assembly speed of the outflow pipe 500 is increased, the manual operation steps are reduced, and the labor intensity and operation difficulty of the workers are reduced. By allowing a part of the outflow pipe 500 to be located in the second groove 322 and another part to be located in the third groove 314, while realizing the connection between the outflow pipe 500 and the lower end of the chromatographic column 100, the outflow pipe 500 is respectively limited by the second groove 322 and the third groove 314, thereby realizing the fixed connection between the outflow pipe 500 and the first leg 310 and the second leg 320.

[0069] Please refer to Figures 1 to 5 , Figure 5 which shows a schematic top view structure of an exemplary bracket.

[0070] As Figures 1 to 5 shown, in some alternative embodiments, the bracket 300 further includes a mounting plate 330. The mounting plate 330 is located on the side of the second leg 320 facing away from the first leg 310 and is connected to both second legs 320. The mounting plate 330 is provided with a perfusion through hole 331 and an outflow through hole 332 that penetrate along the first direction x. The perfusion through hole 331 is in communication with the perfusion pipe 400, and the outflow through hole 332 is in communication with the outflow pipe 500.

[0071] Optionally, the column tube system 10 further includes a connecting member 600. The two connecting members 600 are respectively snapped onto the perfusion through hole 331 and the outflow through hole 332, and are respectively connected to the perfusion pipe 400 and the outflow pipe 500. One end of the perfusion pipe 400 is connected to the mounting plate 330 through the connecting member 600, and the perfusion pipe 400 is in communication with the perfusion through hole 331. The other end is connected to the chromatographic column 100 through the elastic plug 200. One end of the outflow pipe 500 is connected to the mounting plate 330 through the connecting member 600, and the outflow pipe 500 is in communication with the outflow through hole 332. The other end is connected to the chromatographic column 100 through the elastic plug 200.

[0072] In the column tube system 10 of the present application, by providing the connecting member 600, both the perfusion pipe 400 and the outflow pipe 500 can be connected to the mounting plate 330, and the perfusion pipe 400 is in communication with the perfusion through hole 331, and the outflow pipe 500 is in communication with the outflow through hole 332.

[0073] Please refer to Figures 1 to 6 , Figure 6 which shows a schematic side view structure of an exemplary column tube system. Among them, in order to more intuitively display the characteristics of the column tube system, Figure 1 and Figure 6 the perfusion needle assembly and the outflow needle assembly in

[0074] are separated from the mounting plate. In actual applications, the perfusion needle assembly and the outflow needle assembly can be connected to the mounting plate. Figures 1 to 6 As shown in

[0075] In some alternative embodiments, the column tube system 10 further includes a perfusion needle assembly 700 and an outflow needle assembly 800. The perfusion needle assembly 700 includes a first needle seat 710 and a perfusion needle tube 720 connected to the first needle seat 710. The first needle seat 710 is connected to the mounting plate 330, so that the perfusion needle tube 720 communicates with the perfusion tube 400 through the perfusion through hole 331. The outflow needle assembly 800 includes a second needle seat 810 and an outflow needle tube 820 connected to the second needle seat 810. The second needle seat 810 is connected to the mounting plate 330, so that the outflow needle tube 820 communicates with the outflow tube 500 through the outflow through hole 332.

[0076] Optionally, the first needle seat 710 and the perfusion needle tube 720 can be connected by means such as a Luer connector, a buckle, a direct plug connector, a heparin cap, a quick-release connector, a sealing ring, etc. The second needle seat 720 and the outflow needle tube 820 can be connected by means such as a Luer connector, a buckle, a direct plug connector, a heparin cap, a quick-release connector, a sealing ring, etc.

[0077] Optionally, the outflow needle assembly 800 further includes a filter member 830. The filter member 830 communicates with the outflow needle tube 820, and the filter member is used to filter the air in the solution flowing through the outflow needle tube 820.

[0078] Optionally, a plurality of first limiting pieces 333 protrude from the side of the mounting plate 330 facing away from the first leg 310. A part of the first limiting pieces 333 are arranged around the perfusion through hole 331, and another part of the first limiting pieces 333 are arranged around the outflow through hole 332. A limiting groove 334 is formed between two adjacent first limiting pieces 333. At least one second limiting piece 711 protrudes from both the first needle seat 710 and the second needle seat 810. When the second limiting piece 711 of the first needle seat 710 extends into any one of the limiting grooves 334, the first needle seat 710 is connected to the mounting plate 330. When the second limiting piece 711 of the second needle seat 810 extends into any one of the limiting grooves 334, the second needle seat 810 is connected to the mounting plate 330.

[0079] Optionally, four second limiting pieces 711 protrude from both the first needle seat 710 and the second needle seat 810. There are four first limiting pieces 333 on the mounting plate 330 surrounding the perfusion through hole 331, and another four first limiting pieces 333 surrounding the outflow through hole 332.

[0080] In the column tube system 10 of the present application, by providing a plurality of first limiting pieces 333 on the mounting plate 330, a limiting groove 334 is formed between two adjacent first limiting pieces 333, and by providing a plurality of second limiting pieces 711 protruding from the first needle seat 710, when the second limiting piece 711 on the first needle seat 710 extends into the limiting groove 334, the first needle seat 710 and the mounting plate 330 are mutually limited by the first limiting piece 333 and the second limiting piece 711, so that the first needle seat 710 is connected to the mounting plate 330 and the first needle seat 710 cannot rotate relative to the mounting plate 330. By providing a plurality of second limiting pieces 711 protruding from the second needle seat 810, when the second limiting piece 711 on the second needle seat 810 extends into the limiting groove 334, the second needle seat 810 and the mounting plate 330 are mutually limited by the first limiting piece 333 and the second limiting piece 711, so that the second needle seat 810 is connected to the mounting plate 330 and the second needle seat 810 cannot rotate relative to the mounting plate 330.

[0081] In some alternative embodiments, the mounting plate 330 is further provided with an avoidance hole 335 penetrating along the first direction x, and the avoidance hole 335 is located between the perfusion through hole 331 and the outflow through hole 332.

[0082] Optionally, the avoidance hole 335 is used to install a sealing plug, so that when the chromatographic column 100 reacts, it is located in a sealed cavity.

[0083] Please refer to Figure 5 、 Figure 7 and Figure 8 , Figure 7 show a schematic cross-sectional structure diagram of an exemplary generator; Figure 8 show a schematic exploded structure diagram of an exemplary generator.

[0084] As Figure 5 、 Figure 7 and Figure 8 shown, the present application also discloses a generator, which includes a reaction tank 20 and the column tube system 10 of any of the above embodiments. A sealing cavity 21 is provided in the reaction tank 20, and the chromatographic column 100 is located in the sealing cavity 21.

[0085] Optionally, the generator further includes a sealing plug 30, a cover 40, a handle 50 and a housing 60. The reaction tank 20 is a lead tank, and the sealing plug 30 is a lead plug. When the bracket 300 is installed on the reaction tank 20, the chromatographic column 100 extends into the sealing cavity 21, and the sealing plug 30 closes the outlet of the sealing cavity 21 through the avoidance hole 335 on the mounting plate 330, so that the chromatographic column 100 is located in a sealed environment. The housing 60 and the cover 40 are wrapped outside the reaction tank 20, and the handle 50 is connected to the cover 40 for facilitating the movement of the generator.

[0086] Optionally, the mounting plate 330 is further provided with a mounting hole 336 penetrating along the first direction x. When the bolt passes through the mounting hole 336 and is connected to the reaction tank 20, the bracket 300 is fixedly installed on the reaction tank 20.

[0087] Optionally, mounting holes 336 are provided around both the perfusion through-hole 331 and the outflow through-hole 332, and the number of mounting holes 336 around the perfusion through-hole 331 and the outflow through-hole 332 is different, so that the front and back of the bracket 300 can be judged by the different number of mounting holes 336 during installation, reducing the probability of the bracket 300 being installed in the reverse direction.

[0088] As mentioned above, it is only the specific implementation manner of the present application. Those skilled in the art can clearly understand that for the convenience and conciseness of description, the specific working processes of the above-described systems, modules and units can refer to the corresponding processes in the foregoing embodiments, and will not be elaborated herein. It should be understood that the protection scope of the present application is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present application can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of the present application.

Claims

1. A column tube system, characterized in that, include: The chromatographic column has two openings at both ends of its axial direction; Elastic plugs, two of which are connected to two ends of the chromatographic column respectively, and are used to seal the opening of the chromatographic column; The bracket comprises a first leg, on which are provided two limiting plates spaced apart along a first direction, the color layer column and the two elastic plugs are located between the two limiting plates, and the two elastic plugs are respectively in contact with the two limiting plates.

2. The column tube system according to claim 1, characterized in that, It also includes a perfusion tube and an outflow tube, which are respectively connected to one of the elastic plugs and are both connected to the chromatographic column. The perfusion tube is used to transport materials into the chromatographic column, and the outflow tube is used to discharge materials in the chromatographic column.

3. The column tube system according to claim 2, characterized in that, The bracket also includes two second legs, both of which are connected to the first leg, and the second legs include a second support plate and a second groove formed by the second support plate, and at least part of the perfusion tube and at least part of the outflow tube are respectively located in the second grooves of the two second legs.

4. The column tube system according to claim 3, characterized in that, The two second legs are located on the same side of the first leg in the first direction; The bracket also includes a mounting plate, which is located on the side of the second leg away from the first leg and connected to both of the second legs. The mounting plate is provided with an infusion through hole and an outflow through hole penetrating along the first direction, the infusion through hole is connected to the infusion pipe, and the outflow through hole is connected to the outflow pipe.

5. The column tube system according to claim 4, characterized in that, Also includes: An infusion needle assembly, comprising a first needle seat and an infusion needle tube connected to the first needle seat, wherein the first needle seat is connected to the mounting plate so that the infusion needle tube is connected to the infusion tube through the infusion through hole; The outflow needle assembly comprises a second needle seat and an outflow needle tube connected to the second needle seat, wherein the second needle seat is connected to the mounting plate so that the outflow needle tube is connected to the outflow tube through the outflow through hole.

6. The column tube system according to claim 5, characterized in that, A plurality of first limiting pieces are protrudingly provided on one side of the mounting plate away from the first leg, a portion of the first limiting pieces are arranged around the infusion through hole, another portion of the first limiting pieces are arranged around the outflow through hole, and a limiting groove is formed between two adjacent first limiting pieces; At least one second limiting piece is protruding from the first needle seat and the second needle seat. When the second limiting piece of the first needle seat extends into any one of the limiting grooves, the first needle seat is connected to the mounting plate. When the second limiting piece of the second needle seat extends into any one of the limiting grooves, the second needle seat is connected to the mounting plate.

7. The column tube system according to claim 4, characterized in that The mounting plate is also provided with an avoidance hole penetrating along the first direction, and the avoidance hole is located between the injection through hole and the outflow through hole.

8. The column tube system according to claim 3, characterized in that, The first leg comprises a first support plate and a first groove and a third groove formed by the first support plate, the first groove is located between the two limit plates, and at least part of the color layer column is located in the first groove; The outflow pipe includes a first section and a second section which are arranged in sequence, at least a portion of the first section is located in the third groove, and at least a portion of the second section is located in the second groove.

9. The column tube system according to claim 8, wherein One end of the first section facing away from the second section extends out of the third groove and is connected to the elastic plug.

10. A generator, characterized in that, It includes a reaction tank and the column tube system according to any one of claims 1 to 9. A sealing cavity is provided in the reaction tank, and the chromatographic column is located in the sealing cavity.

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