Sample adding instrument, sample storage instrument, sample storage assembly, sample storage method and electronic equipment

Abstract

The invention provides a sample adding instrument, a sample storage instrument, a sample storage assembly, a sample storage method and electronic equipment, the sample adding instrument comprises a plate moving device and a plate frame, the plate frame is provided with at least one plate placing position and at least one cover placing position, and the cover placing position is located on one side of the plate placing position along a first horizontal direction; the plate moving device comprises a translation mechanism, a lifting mechanism and a plate support which are connected in sequence; the translation mechanism can drive the lifting mechanism to drive the plate support to move in the first horizontal direction, so that the plate support moves to correspond to the horizontal positions of the plate placing position and the cover placing position and extends out of the sample adding instrument; the lifting mechanism can drive the plate support to do lifting motion so that the plate support can jack up and bear the sample plate in the plate placing position and the plate cover in the cover placing position. The sample adding instrument provided by the invention can automatically complete sample adding operation, and in the process of adding samples into the sample storage instrument, an operator only needs to place a sample plate and a plate cover in the plate placing position and the cover placing position respectively, so that a large amount of manual operation time is saved, and the convenience of sample adding operation is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug sensitivity testing equipment, and specifically, to a sample adding instrument, a sample storage instrument, a sample storage assembly including the sample adding instrument and the sample storage instrument, a sample storage method applied to the sample storage assembly, and an electronic device. Background Art

[0002] In medical diagnosis and microbiological research, drug sensitivity testing is a key step in determining the sensitivity of pathogens to antibiotics and is crucial for guiding clinical medication.

[0003] In the prior art, usually, the liquid in the sample needs to be sucked out by a pipette in the form of manual operation, and the liquid is dropped into each sample slot of the drug sensitivity plate, and then the drug sensitivity plate is manually placed into a heat preservation device for heat preservation treatment for a period of time to complete the drug sensitivity test. However, the manual operation steps are cumbersome and time-consuming, greatly wasting the time of drug sensitivity tests and increasing the labor cost.

[0004] Therefore, how to provide an automated device that can improve the convenience of sample adding operation has become a technical problem to be solved urgently in this field. Summary of the Invention

[0005] The present invention aims to solve one of the technical problems in the related art to a certain extent. For this purpose, the present invention provides a sample adding instrument, a sample storage instrument, a sample storage assembly including the sample adding instrument and the sample storage instrument, a sample storage method applied to the sample storage assembly, and an electronic device. The sample adding instrument can automatically complete the sample adding action, thereby saving a large amount of manual operation time and improving the convenience of sample adding operation.

[0006] To achieve the above object, as an aspect of the present invention, there is provided a sample adding instrument, including a plate moving device and a plate rack, wherein,

[0007] The plate rack has at least one plate placing position and at least one plate covering position, and the plate covering position is located on one side of the plate placing position along a first horizontal direction;

[0008] The plate moving device includes a translation mechanism, a lifting mechanism and a plate holder connected in sequence; the translation mechanism can drive the lifting mechanism to drive the plate holder to move along the first horizontal direction, so that the plate holder moves to a position corresponding to the horizontal positions of the plate placing position and the plate covering position, and extends out of the sample adding instrument; the lifting mechanism can drive the plate holder to move up and down, so that the plate holder lifts and bears the sample plate in the plate placing position and the plate cover in the plate covering position.

[0009] Optionally, the plate rack has at least a plurality of plate placement positions and a plurality of lid placement positions. The plurality of plate placement positions are distributed along the first horizontal direction, and the plurality of lid placement positions are distributed along the vertical direction.

[0010] Optionally, the plate rack includes a first side frame and a second side frame. The first side frame and the second side frame are respectively disposed on both sides of the plate moving device along the second horizontal direction, and the second horizontal direction intersects the first horizontal direction;

[0011] The first side frame has a first plate placement groove and a first lid placement groove, and the horizontal positions of the first plate placement groove and the first lid placement groove are distributed along the first horizontal direction. The second side frame has a second plate placement groove and a second lid placement groove. The first plate placement groove and the second plate placement groove together form the plate placement position, and the first lid placement groove and the second lid placement groove together form the lid placement position.

[0012] Optionally, the first side frame includes a first side plate, a first plate placement table, and a first lid placement table. The first plate placement table and the first lid placement table are both fixedly disposed on the side of the first side plate facing the second side frame. The first plate placement groove is formed on the first plate placement table, and the first lid placement groove is formed on the first lid placement table;

[0013] The second side frame includes a second side plate, a second plate placement table, and a second lid placement table. The second plate placement table and the second lid placement table are both fixedly disposed on the side of the second side plate facing the first side frame. The second plate placement groove is formed on the second plate placement table, and the second lid placement groove is formed on the second lid placement table.

[0014] Optionally, the heights of the first lid placement table and the second lid placement table are greater than the heights of the first plate placement table and the second plate placement table.

[0015] Optionally, the top surfaces of the first plate placement table and the first lid placement table are flush with the top surface of the corresponding position of the first side plate, and the top surfaces of the second plate placement table and the second lid placement table are flush with the top surface of the corresponding position of the second side plate.

[0016] Optionally, the projected contour shapes of the plate placement position and the lid placement position on the horizontal plane are both rounded rectangles.

[0017] Optionally, the sample adding instrument further includes a liquid transfer device and a sample rack. The position of the sample rack is relatively fixed with respect to the position of the plate rack. The liquid transfer device includes a moving device and a pipette. The moving device can drive the pipette to move to the sample rack so that the pipette can aspirate the liquid in the sample placed on the sample rack, and can also drive the pipette to move to the plate placement position so that the pipette can drip the liquid into the sample groove of the sample plate placed in the plate placement position.

[0018] Optionally, the plate moving device further comprises a barcode reading module, wherein the barcode reading module is fixedly connected to the plate support, and the barcode reading module is used to read the barcode information of the sample plate located on the plate support.

[0019] Optionally, the sample rack is fixedly arranged on a side of the first side frame or the second side frame facing away from the plate moving device.

[0020] Optionally, the sample loading instrument further comprises a box, the plate moving device and the plate rack are both arranged in the box, a sample outlet is provided on the side wall of the box, and the plate support of the plate moving device can extend from the sample outlet to the outside of the box.

[0021] Optionally, the sample injector also includes a tip rack and a tip disposal module, the tip rack has a plurality of tip fixing grooves, the tip disposal module includes a release plate and a tip box, the release plate is arranged on the top of the tip box, and a release hole is formed on the release plate and penetrates the release plate along the thickness direction, the moving device can drive the pipette gun to move to the tip rack so that the end of the pipette gun extends into the tip in the tip fixing groove, and can also drive the pipette gun to move to the tip disposal module so that the end of the pipette gun drives the tip to extend into the release hole and pull it out, so that the tip detaches from the pipette gun and falls into the tip box.

[0022] Optionally, the translation mechanism includes a first guide rail and a first displacement portion, the first guide rail extends along the first horizontal direction, the first displacement portion is movably disposed on the first guide rail and can move along the first guide rail, and the lifting mechanism is connected to the first displacement portion;

[0023] Optionally, the translation mechanism further includes a rotating motor, a driving wheel, a driven wheel, a transmission belt and a translation mounting seat, the translation mounting seat and the sample rack are relatively fixed in position, the driving wheel and the driven wheel are arranged on the translation mounting seat at intervals along the first horizontal direction, the transmission belt is mounted on the driving wheel and the driven wheel, the rotating motor can drive the driving wheel to rotate around its own axis, so that the transmission belt drives the driven wheel to rotate around its own axis, and the first displacement portion is fixedly connected to the transmission belt.

[0024] Optionally, the driving wheel and the driven wheel are both arranged on the top of the translation mounting seat, and the rotating motor is arranged inside the translation mounting seat.

[0025] Optionally, the lifting mechanism includes a lifting base, a lifting motor, a driving wheel, a lifting belt, a driven wheel, a transmission lead screw, a threaded mating portion, and a second displacement portion. The lifting base is fixedly connected to the first displacement portion, the lifting motor is fixedly connected to the lifting base, the transmission lead screw is movably disposed on the lifting base, the driving wheel is connected to the output shaft of the lifting motor, the driven wheel is coaxially and fixedly connected to the transmission lead screw, the lifting belt is sleeved on the driving wheel and the driven wheel, the threaded mating portion has an internal threaded hole, and the threaded mating portion is sleeved on the transmission lead screw. The second displacement portion is fixedly connected to the threaded mating portion;

[0026] The lifting motor can drive the driving wheel to rotate, so as to drive the driven wheel and the transmission lead screw to rotate through the lifting belt, and further enable the threaded mating portion to drive the second displacement portion to move up and down. The plate holder is fixedly connected to the second displacement portion.

[0027] As a second aspect of the present invention, there is provided a sample storage instrument, which includes a housing and at least one sample tower disposed in the housing. The sample tower is disposed in the housing, and there are a plurality of sample storage positions distributed in the height direction in the sample tower. There is a sample inlet on the side wall of the housing. The sample inlet is used for the plate holder of the pipetting device provided by the present invention to extend into the housing, and place the sample plate in the sample storage position and take out the sample plate in the sample storage position.

[0028] Optionally, the sample storage instrument further includes a temperature control device, and the temperature control device can heat the gas environment in the housing to control the temperature inside the housing.

[0029] Optionally, the sample storage instrument further includes a rotating device. A plurality of the sample towers are provided on the rotating device, and the rotating device can drive the plurality of sample towers to rotate so that the plurality of sample towers face the sample inlet in sequence.

[0030] Optionally, the sample storage instrument further includes a code scanning device, and the code scanning device can scan and read the identification code information on the sample plates stored in each of the sample storage positions on the sample tower.

[0031] Optionally, the code scanning device includes a lifting module and a code reader. The lifting module can drive the code reader to move in the vertical direction so that the code reader corresponds to the height of each layer of the sample storage positions, and the code reader can scan and read the identification code information on the sample plate.

[0032] Optionally, the lifting module includes a vertical guide rail, a code reading mounting base, a lifting lead screw, and a lead screw driving part. The lifting lead screw is arranged in the same direction as the vertical guide rail. The code reading mounting base is movably connected to the vertical guide rail and has a threaded fitting hole. The lifting lead screw passes through the threaded fitting hole. The code reader is fixedly connected to the code reading mounting base. The lead screw driving part can drive the lifting lead screw to rotate, so as to drive the code reading mounting base to drive the code reader to move in the vertical direction.

[0033] Optionally, the code scanning device further includes a mounting frame, which includes a mounting top plate and a pair of mounting side plates. The tops of the mounting side plates are respectively fixedly connected to both ends of the mounting top plate, and the bottoms of the mounting side plates are fixedly connected to the bottom wall of the housing. The vertical guide rail is fixedly arranged on the mounting side plates, and the top of the lifting lead screw passes through the mounting top plate and is connected to the lead screw driving part.

[0034] Optionally, the lead screw driving part includes a lifting motor and a pulley transmission structure. The lifting motor is fixedly arranged on the mounting top plate, and the output shaft of the lifting motor is connected to the top of the lifting lead screw through the pulley transmission structure. The lifting motor can drive the lifting lead screw to rotate through the pulley transmission structure.

[0035] As a third aspect of the present invention, there is provided a sample storage assembly, which includes the sample adding instrument provided by the present invention and the sample storage instrument provided by the present invention.

[0036] As a fourth aspect of the present invention, there is provided a sample storage method, which is used for the sample storage assembly provided by the present invention. The sample storage method includes:

[0037] Controlling the translation mechanism of the plate moving device to drive the plate holder to move to a position corresponding to the plate placing position, and controlling the lifting mechanism of the plate moving device to drive the plate holder to lift and carry the sample plate in the plate placing position;

[0038] Controlling the translation mechanism to drive the plate holder to move to a position corresponding to the plate covering position, and controlling the lifting mechanism to drive the plate holder to lift the plate cover in the plate covering position, so that the plate cover covers the sample plate;

[0039] Controlling the translation mechanism to drive the plate holder to pass through the sample inlet of the sample storage instrument and extend into the housing, so that the sample plate enters the sample storage position of the sample tower;

[0040] Controlling the lifting mechanism to drive the plate holder to move up and down and separate from the sample plate, and controlling the translation mechanism to drive the plate holder to move and leave the housing.

[0041] As a fifth aspect of the present invention, there is provided an electronic device, comprising:

[0042] One or more processors;

[0043] A memory storing one or more computer programs, which, when executed by the one or more processors, cause the one or more processors to implement the sample storage method provided by the present invention.

[0044] In the pipetting instrument, sample storage instrument, sample storage component, sample storage method and electronic device provided by the present invention, the pipetting instrument includes a plate transfer device and a plate rack. The plate rack has a plate placement position for placing a sample plate and a cover placement position for placing a plate cover. The translation mechanism and lifting mechanism of the plate transfer device can respectively drive the plate carrier to move along a first horizontal direction and perform a lifting movement, so as to drive the plate carrier to move below the plate placement position and pass through the plate placement position from bottom to top, and lift the sample plate in the plate placement position. Then, it drives the plate carrier to move below the cover placement position and pass through the cover placement position from bottom to top, and closes the plate cover in the cover placement position with the sample plate. Then, it can also drive the plate carrier to extend outside the pipetting instrument, so as to send the covered sample plate into the sample storage instrument (drug sensitivity instrument). During the process of adding samples to the sample storage instrument, the operator only needs to place the sample plate and the plate cover in the plate placement position and the cover placement position respectively, and the entire sample addition operation can be automatically completed by the machine, thereby saving a large amount of manual operation time and improving the convenience of the sample addition operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] The present invention will be further described below with reference to the accompanying drawings:

[0046] Figure 1 is a schematic structural diagram of a pipetting instrument provided by an embodiment of the present invention;

[0047] Figure 2 is a schematic structural diagram of the pipetting instrument with part of the box body hidden provided by an embodiment of the present invention;

[0048] Figure 3 is a schematic structural diagram of the pipetting instrument with part of the box body hidden provided by an embodiment of the present invention;

[0049] Figure 4 is a schematic structural diagram of a plate rack in a sample storage instrument provided by an embodiment of the present invention;

[0050] Figure 5 is a schematic structural diagram of a plate rack in a sample storage instrument provided by an embodiment of the present invention;

[0051] Figure 6 is a schematic structural diagram of a plate rack in a sample storage instrument provided by an embodiment of the present invention;

[0052] Figure 7It is a schematic structural diagram of the plate moving device in the sample storage instrument provided by an embodiment of the present invention;

[0053] Figure 8 It is Figure 7 a partial enlarged schematic diagram of area A in

[0054] Figure 9 It is a schematic structural diagram of the pipette tip holder and the pipette tip waste module in the sample storage instrument provided by an embodiment of the present invention;

[0055] Figure 10 It is a schematic structural diagram of the sample storage instrument provided by an embodiment of the present invention;

[0056] Figure 11 It is a schematic structural diagram of the sample storage instrument with part of the housing hidden provided by an embodiment of the present invention;

[0057] Figures 12 to 13 It is a schematic diagram of the docking principle of the pipetting instrument and the sample storage instrument in the sample storage component provided by an embodiment of the present invention;

[0058] Figure 14 It is a schematic structural diagram of the sample storage component with the outer shell hidden provided by an embodiment of the present invention;

[0059] Figure 15 It is a schematic structural diagram of the sample tower and the rotating device in the sample storage instrument provided by an embodiment of the present invention;

[0060] Figure 16 It is a schematic structural diagram of the barcode scanning device in the sample storage instrument provided by an embodiment of the present invention;

[0061] Figure 17 It is a schematic structural diagram of the moving device in the sample storage instrument provided by an embodiment of the present invention;

[0062] Figure 18 It is a schematic structural diagram of the electronic device provided by an embodiment of the present invention.

[0063] Explanation of reference numerals:

[0064] Sampling instrument 10; Plate transfer device 100; Translation mechanism 110; First guide rail 111; First displacement part 112; Rotation motor 113; Driving wheel 114; Driven wheel 115; Transmission belt 116; Translation mounting seat 117; Lifting mechanism 120; Lifting seat 121; Lifting motor 122; Lifting belt 123; Transmission lead screw 124; Threaded mating part 125; Second displacement part 126; Plate support 130; Rolling structure 140; Rolling seat 141; Rotating shaft 142; Roller 143; Code reading module 150; Plate rack 200; First side frame 210; First side plate 211; First plate placement table 212; First cover placement table 213; Second side frame 220; Second side plate 221; Second plate placement table 222; Second cover placement table 223; Plate placement position a; First plate placement groove a1; First cover placement groove b1; Cover placement position b; Second plate placement groove a2; Second cover placement groove b2; First horizontal direction x; Pipetting device 310; Moving device 311; Pipette 312; Sample rack 320; Box body 400; Box body main body 410; Sample feeding port 411; Sealing cover 420; Tip rack 510; Tip fixing groove 511; Tip waste module 520; Loosening plate 521; Tip box 522; Sample storage instrument 20; Housing 600; Sealing door panel 610; Hinge 620; Sample tower rack 700; Sample storage position c; Rotating device 810; Rotating shaft seat 811; Motor 812; First belt 813; Bottom wheel 814; Adapter shaft seat 815; Top wheel 816; Second belt 817; Temperature control device 820; Scanning code device 900; Lifting mechanism lifting module 910; Vertical guide rail 912; Code reading mounting seat 913; Lifting lead screw 914; Lead screw driving part 915; Code reader 920; Mounting frame 930; Picking and placing module 940; Sample plate 11; Plate cover 12. Detailed implementation mode

[0065] The embodiments of the present invention will be described in detail below. Examples of the embodiments are shown in the drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. Based on the embodiments in the implementation manners, it is intended to explain the present invention and should not be construed as a limitation of the present invention.

[0066] As used herein, the phrase "in one embodiment" or "example" or "instance" means that a particular feature, structure, or characteristic described in connection with the embodiment itself can be included in at least one embodiment of the present disclosure. The appearances of the phrase "in one embodiment" in various places in the specification do not necessarily refer to the same embodiment.

[0067] To solve the above technical problems, as one aspect of the present invention, a sampling instrument is provided, as Figures 1 to 3 shown, the sampling instrument 10 includes a plate transfer device 100 and a plate rack 200, wherein,

[0068] AsFigure 4 As shown, the plate rack 200 has at least one plate placement position a and at least one lid placement position b, and the lid placement position b is located on one side of the plate placement position a along the first horizontal direction x;

[0069] As Figure 7 shown, the plate moving device 100 includes a translation mechanism 110, a lifting mechanism 120 and a plate support 130 connected in sequence; the translation mechanism 110 can drive the lifting mechanism 120 to drive the plate support 130 to move along the first horizontal direction x, so that the plate support 130 moves to a position corresponding to the horizontal positions of the plate placement position a and the lid placement position b, and extends out of the sampler 10; the lifting mechanism 120 can drive the plate support 130 to move up and down, so that the plate support 130 jacks up and bears the sample plate 11 in the plate placement position a and the plate lid 12 in the lid placement position b.

[0070] The sampler provided by the present invention includes a plate moving device 100 and a plate rack 200, wherein the plate rack 200 has a plate placement position a for placing the sample plate 11 and a lid placement position b for placing the plate lid 12. The translation mechanism 110 and the lifting mechanism 120 of the plate moving device 100 can respectively drive the plate support 130 to move along the first horizontal direction x and move up and down. Thus, the plate support 130 can be driven to move below the plate placement position a and pass through the plate placement position a from bottom to top, and lift the sample plate 11 in the plate placement position a. Then, the plate support 130 is driven to move below the lid placement position b and pass through the lid placement position b from bottom to top, and the plate lid 12 in the lid placement position b is covered with the sample plate 11. Then, the plate support 130 can also be driven to extend out of the sampler 10, so as to send the covered sample plate 11 into the sample storage instrument 20 (drug sensitivity instrument). During the process of adding samples to the sample storage instrument 20, the operator only needs to place the sample plate 11 and the plate lid 12 in the plate placement position a and the lid placement position b respectively, and the whole sample adding operation can be automatically completed by the machine, thus saving a large amount of manual operation time and improving the convenience of the sample adding operation.

[0071] Optionally, as Figure 5 shown, the plate rack 200 may have 1 plate placement position a and 1 lid placement position b, or, as Figure 6 shown, the plate rack 200 may have a plurality of plate placement positions a and a plurality of lid placement positions b. The plurality of plate placement positions a are distributed along the first horizontal direction x, and the plurality of lid placement positions b are distributed along the vertical direction, so that the operator can place a plurality of sample plates 11 and a plurality of plate lids 12 at one time.

[0072] As an alternative embodiment of the present invention, as Figure 4 shown, the plate rack 200 includes a first side rack 210 and a second side rack 220. The first side rack 210 and the second side rack 220 are respectively arranged on both sides of the plate moving device 100 along the second horizontal direction y, and the second horizontal direction y intersects with the first horizontal direction x;

[0073] The first side frame 210 is provided with a first plate placing groove a1 and a first cover placing groove b1, and the horizontal positions of the first cover placing groove b1 and the second plate placing groove a2 are distributed along the first horizontal direction x. The second side frame 220 is provided with a second plate placing groove a2 and a second cover placing groove b2. The first plate placing groove a1 and the second plate placing groove a2 together form a plate placing position a, and the first cover placing groove b1 and the second cover placing groove b2 together form a cover placing position b.

[0074] As an alternative embodiment of the present invention, as Figure 4 shown, the first side frame 210 includes a first side plate 211, a first plate placing platform 212 and a first cover placing platform 213. The first plate placing platform 212 and the first cover placing platform 213 are both fixedly arranged on the side of the first side plate 211 facing the second side frame 220. The first plate placing groove a1 is formed on the first plate placing platform 212, and the first cover placing groove b1 is formed on the first cover placing platform 213;

[0075] The second side frame 220 includes a second side plate 221, a second plate placing platform 222 and a second cover placing platform 223. The second plate placing platform 222 and the second cover placing platform 223 are both fixedly arranged on the side of the second side plate 221 facing the first side frame 210. The second plate placing groove a2 is formed on the second plate placing platform 222, and the second cover placing groove b2 is formed on the second cover placing platform 223.

[0076] As an alternative embodiment of the present invention, as Figure 4 shown, the heights of the first cover placing platform 213 and the second cover placing platform 223 are greater than the heights of the first plate placing platform 212 and the second plate placing platform 222. Thus, the movement path when the plate support 130 extends out is forward, upward, forward, upward, forward, making the movement of the plate shifting device 100 more coherent.

[0077] In the case where the plate rack 200 only has 1 plate placing position a and 1 cover placing position b, as an alternative embodiment of the present invention, as Figure 4 shown, the top surfaces of the first plate placing platform 212 and the first cover placing platform 213 are flush with the top surface of the corresponding position of the first side plate 211, and the top surfaces of the second plate placing platform 222 and the second cover placing platform 223 are flush with the top surface of the corresponding position of the second side plate 221.

[0078] As an alternative embodiment of the present invention, as Figure 4 shown, the projected contour shapes of the plate placing position a and the cover placing position b on the horizontal plane are both rounded rectangles.

[0079] As an alternative embodiment of the present invention, as Figure 2 、 Figure 3As shown, the pipetting instrument 10 further includes a liquid transfer device 310 and a sample rack 320. The position of the sample rack 320 is relatively fixed with respect to the position of the plate rack 200. The liquid transfer device 310 includes a moving device 311 and a pipette 312. The moving device 311 can drive the pipette 312 to move to the sample rack 320 so that the pipette 312 can aspirate the liquid in the sample placed on the sample rack 320, and can also drive the pipette 312 to move to the plate placement position a so that the pipette 312 can drip the liquid into the sample wells of the sample plate 11 placed in the plate placement position a.

[0080] In an embodiment of the present invention, the pipetting instrument 10 further includes a liquid transfer device 310. The liquid transfer device 310 can automatically aspirate the liquid from the sample placed on the sample rack 320 and complete the operation of transferring the liquid into the sample wells of the sample plate 11. The operator only needs to place the empty sample plate 11 in the plate placement position a, thereby further saving the manual operation time and improving the convenience of the pipetting operation.

[0081] As an alternative embodiment of the present invention, as Figure 17 shown, the moving device 311 includes a fixed frame 3111, a first driving part 3112, a first guide rail 3113, a first moving frame 3114, a second driving part 3115, a second guide rail 3116, a second moving frame 3117 and a third driving part 3118. Among them, the bottom of the fixed frame 3111 is fixedly connected to the bottom wall of the box body 400. The first driving part 3112 and the first guide rail 3113 are both arranged on the fixed frame 3111. The first guide rail 3113 extends along the first horizontal direction x. The first moving frame 3114 is movably arranged on the first guide rail 3113. The first driving part 3112 can drive the first moving frame 3114 to move along the first guide rail 3113;

[0082] The second driving part 3115 and the second guide rail 3116 are both arranged on the first moving frame 3114. The second guide rail 3116 extends along the second horizontal direction y. The second moving frame 3117 is movably arranged on the second guide rail 3116. The second driving part 3115 can drive the second moving frame 3117 to move along the second guide rail 3116; The third driving part 3118 is connected between the pipette 312 and the second moving frame 3117 and can drive the pipette 312 to move in the vertical direction.

[0083] That is, the first driving part 3112 and the second driving part 3115 respectively drive the pipette 312 to move in the first horizontal direction x and the second horizontal direction y to change the horizontal position of the pipette 312, and the third driving part 3118 drives the pipette 312 to expand and contract in the vertical direction to realize the operation of entering and exiting the sample and the sample wells of the sample plate 11.

[0084] Optionally, as Figure 17As shown, both the first driving part 3112 and the second driving part 3115 can be pulley driving structures, that is, including a motor, a driving wheel, a driven wheel and a belt. The motor drives the driving wheel to rotate, so that the driven wheel and the belt sleeved on the driving wheel and the driven wheel move, and further the moving frame fixedly connected to the belt moves along the corresponding guide rail.

[0085] Or in other embodiments of the present invention, the first driving part 3112 and the second driving part 3115 can also be other forms of driving mechanisms such as pneumatic cylinders, hydraulic cylinders, electric cylinders, linear motors, lead screws, etc.

[0086] Optionally, the moving device 311 further includes a third guide rail and a third moving frame (not shown in the figure). The third guide rail is arranged on the second moving frame 3117 and extends in the vertical direction. The third moving frame is movably arranged on the third guide rail and fixedly connected to the pipette 312. The third driving part 3118 can drive the third moving frame to move up and down along the third guide rail, so as to drive the pipette 312 to stretch in the vertical direction.

[0087] Optionally, the third driving part 3118 can also be a pulley driving structure, or other forms of driving mechanisms such as pneumatic cylinders, hydraulic cylinders, electric cylinders, linear motors, lead screws, etc.

[0088] As an optional embodiment of the present invention, the sample rack 320 is fixedly arranged on one side of the first side rack 210 or the second side rack 220 away from the plate moving device 100.

[0089] As an optional embodiment of the present invention, as Figure 1 shown, the pipetting instrument 10 further includes a box body 400. The plate moving device 100 and the plate rack 200 are both arranged in the box body 400. There is a sample outlet 411 on the side wall of the box body 400. The plate carrier 130 of the plate moving device 100 can extend out of the box body 400 through the sample outlet 411.

[0090] As an optional embodiment of the present invention, as Figure 2 、 Figure 3 、 Figure 9 shown, the pipetting instrument 10 further includes a pipette tip rack 510 and a pipette tip waste module 520. The pipette tip rack 510 has a plurality of pipette tip fixing slots 511. The pipette tip waste module 520 includes a release plate 521 and a pipette tip box 522. The release plate 521 is arranged on the top of the pipette tip box 522. A release hole penetrating the release plate 521 in the thickness direction is formed on the release plate 521. The moving device 311 can drive the pipette 312 to move to the pipette tip rack 510, so that the end of the pipette 312 extends into the pipette tip in the pipette tip fixing slot 511, and can also drive the pipette 312 to move to the pipette tip waste module 520, so that the end of the pipette 312 drives the pipette tip to extend into the release hole and be pulled out, so that the pipette tip is separated from the pipette 312 and falls into the pipette tip box 522.

[0091] Optionally, as shown in Figure 2 , Figure 3 , Figure 9 , the release holes on the release plate 521 are gourd-shaped holes.

[0092] Optionally, as shown in Figure 2 , Figure 3 , Figure 9 , the release plate 521 is fixedly arranged on the suction head holder 510.

[0093] As an optional implementation manner of the present invention, as shown in Figure 7 , the plate moving device 100 further includes a code reading module 150. The code reading module 150 is fixedly connected to the plate holder 130. The code reading module 150 is used to read the barcode information of the sample plate 11 located on the plate holder 130, so that the sampler 10 can send the barcode information of the sample plate 11 to the sample storage device 20, which is convenient for the sample storage device 20 to identify and manage the newly added sample plate 11.

[0094] As an optional implementation manner of the present invention, as shown in Figure 7 , the translation mechanism 110 includes a first guide rail 111 and a first displacement part 112. The first guide rail 111 extends along the first horizontal direction x. The first displacement part 112 is movably arranged on the first guide rail 111 and can move along the first guide rail 111. The lifting mechanism 120 is connected to the first displacement part 112.

[0095] As an optional implementation manner of the present invention, as shown in Figure 7 , the translation mechanism 110 further includes a rotating motor 113, a driving wheel 114, a driven wheel 115, a transmission belt 116 and a translation mounting seat 117. The translation mounting seat 117 is relatively fixed in position with the sample holder 320. The driving wheel 114 and the driven wheel 115 are arranged on the translation mounting seat 117 at intervals along the first horizontal direction x. The transmission belt 116 is sleeved on the driving wheel 114 and the driven wheel 115. The rotating motor 113 can drive the driving wheel 114 to rotate around its own axis, so that the transmission belt 116 drives the driven wheel 115 to rotate around its own axis. The first displacement part 112 is fixedly connected to the transmission belt 116.

[0096] As an optional implementation manner of the present invention, as shown in Figure 7 , both the driving wheel 114 and the driven wheel 115 are arranged on the top of the translation mounting seat 117, and the rotating motor 113 is arranged inside the translation mounting seat 117.

[0097] As an optional implementation manner of the present invention, as shown in Figure 7As shown in the figure, the lifting mechanism 120 includes a lifting base 121, a lifting motor 122, a driving wheel, a lifting belt 123, a driven wheel, a transmission lead screw 124, a threaded mating part 125, and a second displacement part 126. The lifting base 121 is fixedly connected to the first displacement part. The lifting motor 122 is fixedly connected to the lifting base 121. The transmission lead screw 124 is movably arranged on the lifting base 121. The driving wheel is connected to the output shaft of the lifting motor 122. The driven wheel is coaxial with and fixedly connected to the transmission lead screw 124. The lifting belt 123 is sleeved on the driving wheel and the driven wheel. The threaded mating part 125 has an internal threaded hole and is sleeved on the transmission lead screw 124. The second displacement part 126 is fixedly connected to the threaded mating part 125;

[0098] The lifting motor 122 can drive the driving wheel to rotate, so as to drive the driven wheel and the transmission lead screw 124 to rotate through the lifting belt 123, and further drive the threaded mating part 125 to drive the second displacement part 126 to move up and down. The plate holder 130 is fixedly connected to the second displacement part 126.

[0099] As a preferred embodiment of the present invention, as Figure 7 shown, the plate shifting device 100 further includes a code reading module 150. The code reading module 150 is fixedly connected to the plate holder 130. The code reading module 150 is used to read the barcode information of the sample plate 11 located on the plate holder 130.

[0100] As a preferred embodiment of the present invention, as Figure 10 shown, an inlet is formed on the housing 600 of the sample storage instrument 20 (drug susceptibility instrument), and a sealing door panel 610 is arranged at the inlet. The sealing door panel 610 can be pushed inward when the plate holder 130 extends into the inlet, and automatically returns to the Figure 10 state of closing the inlet as shown in the figure after the plate holder 130 is retracted.

[0101] Optionally, as Figure 10 shown, the sealing door panel 610 is hingedly connected to the housing 600 through a hinge 620, that is, the sealing door panel 610 is a revolving door. An elastic member (such as a torsion spring) is further arranged at the connection between the sealing door panel 610 and the housing 600. The elastic member can drive the sealing door panel 610 to rotate to close the inlet through elastic force.

[0102] As a preferred embodiment of the present invention, as Figure 7 、 Figure 8 shown, the plate shifting device 100 further includes a rolling structure 140. The rolling structure 140 is arranged on one side of the plate holder 130 facing its extending direction. The rolling structure 140 can be in rolling contact with the sealing door panel 610 when the plate holder 130 extends into the inlet, so as to reduce the friction between the plate shifting device 100 and the sealing door panel 610 during the process of pushing the sealing door panel 610 inward and ensure the smoothness of the sample feeding action.

[0103] Optionally, as Figure 8 shown, the rolling structure 140 includes a rolling base 141, a rotating shaft 142, and rollers 143. The rolling base 141 is fixedly connected to the plate support 130. The rotating shaft 142 is fixedly arranged on the rolling base 141 and is parallel to the edge of the corresponding side of the plate support 130. The rollers 143 are sleeved on the rotating shaft 142 and can rotate around the rotating shaft 142.

[0104] Optionally, as Figure 8 shown, the rolling structures 140 can be arranged in pairs.

[0105] In other embodiments of the present invention, the rolling structure 140 can also adopt other forms of rolling contact structures. For example, rolling contact can be achieved through balls and the sealing door panel 610.

[0106] As a preferred embodiment of the present invention, as Figure 1 shown, the box body 400 includes a box body main body 410 and a sealing cover 420. The sealing cover 420 can selectively seal the opening at the top of the box body main body 410, thereby facilitating the staff to open the box body 400 and place the sample plate 11, the plate cover 12, and the sample into the sampler 10.

[0107] Optionally, as Figure 1 shown, one side of the box body main body 410 has a sample feeding port 411, and the plate support 130 can extend out of the box body 400 through the sample feeding port 411.

[0108] Optionally, the sampler further includes a control device for controlling the movement of each moving part (such as the translation mechanism 110, the lifting mechanism 120, the liquid transfer device 310, etc.) in the sampler.

[0109] Optionally, the control device of the sampler can also be used to communicate with the control device in the sample storage instrument 20 or directly communicate with each component in the sample storage instrument 20 to control the operation of the corresponding components in the sample storage instrument 20. For example, controlling the temperature-changing device 820 in the sample storage instrument 20 to change the temperature, or controlling the rotation of the rotating device 810 in the sample storage instrument 20, and the pick-and-place module 940 of the code scanning device 900 to pick and place the corresponding sample plate 11, etc.

[0110] Optionally, a docking plug is provided on the box body 400. When the sampler is docked with the sample storage instrument 20, the docking plug on the box body 400 can be plugged into the corresponding plug on the sample storage instrument 20, so that the control device of the sampler can communicate with the control device or each component in the sample storage instrument 20 through a cable.

[0111] As the second aspect of the present invention, as Figure 10 , Figure 11As shown, a sample storage instrument 20 is provided. The sample storage instrument 20 includes a housing 600 and at least one sample tower 700 disposed in the housing 600. The sample tower 700 is disposed in the housing 600 and, as Figure 5 , Figure 6 shown, the sample tower 700 has a plurality of sample storage positions c distributed in the height direction. An inlet is provided on the side wall of the housing 600. The inlet is used for the plate holder 130 of the plate transfer device 100 in the pipetting instrument 10 provided by the present invention to extend into the housing 600, and place the sample plate 11 in the sample storage position c and take out the sample plate 11 in the sample storage position c.

[0112] The sample storage instrument 20 provided by the present invention is used in cooperation with the pipetting instrument 10 provided by the present invention. The pipetting instrument 10 includes a plate transfer device 100 and a plate rack 200. The plate rack 200 has a plate placement position a for placing the sample plate 11 and a lid placement position b for placing the plate lid 12. The translation mechanism 110 and the lifting mechanism 120 of the plate transfer device 100 can respectively drive the plate holder 130 to move along the first horizontal direction x and perform a lifting movement, so as to drive the plate holder 130 to move below the plate placement position a and pass through the plate placement position a from bottom to top, and lift the sample plate 11 in the plate placement position a. Then, drive the plate holder 130 to move below the lid placement position b and pass through the lid placement position b from bottom to top, and cover the plate lid 12 in the lid placement position b with the sample plate 11. Then, it can also drive the plate holder 130 to extend out of the pipetting instrument 10, so as to send the covered sample plate 11 into the sample storage instrument 20. During the process of pipetting into the sample storage instrument 20, the operator only needs to place the sample plate 11 and the plate lid 12 in the plate placement position a and the lid placement position b respectively, and align the pipetting instrument 10 with the sample storage instrument 20 (as Figures 12 to 14 shown). The entire pipetting operation can be automatically completed by the machine, thus saving a large amount of manual operation time and improving the convenience of the pipetting operation.

[0113] Optionally, the sample storage instrument 20 provided by the present invention can be used for drug sensitivity tests, that is, the sample storage instrument 20 can be a drug sensitivity instrument.

[0114] As an alternative embodiment of the present invention, as Figure 11 shown, the sample storage instrument 20 further includes a temperature control device 820. The temperature control device 820 can heat the gas environment in the housing 600 to control the temperature inside the housing 600.

[0115] As an alternative embodiment of the present invention, as Figure 11 shown, the sample storage instrument 20 further includes a rotating device 810. A plurality of sample towers 700 are provided on the rotating device 810, and the rotating device 810 can drive the plurality of sample towers 700 to rotate so that the plurality of sample towers 700 are sequentially oriented towards the inlet.

[0116] As an alternative embodiment of the present invention, as Figure 15 shown, the rotating device 810 includes a rotating shaft seat 811, a motor 812, a motor wheel (not shown in the figure), a first belt 813, a bottom wheel 814, a transfer shaft (not shown in the figure), a transfer shaft seat 815, a top wheel 816, a second belt 817, an internal gear (not shown in the figure), and a tower shaft (not shown in the figure). Among them, the rotating shaft seat 811 is fixedly arranged in the sample storage instrument 20, the tower shaft is movably arranged in the rotating shaft seat 811 and can rotate around the vertical axis, and a plurality of sample towers 700 are distributed around the tower shaft and fixedly connected to the tower shaft;

[0117] The output end of the motor 812 is fixedly connected to the motor wheel. The first belt 813 is wound around the motor wheel and the bottom wheel 814. The transfer shaft is movably arranged in the transfer shaft seat 815 and can rotate around the vertical axis. The bottom wheel 814 and the top wheel 816 are respectively fixedly connected to the upper and lower ends of the transfer shaft. The second belt 817 is wound around the top wheel 816 and the internal gear. The internal gear is fixedly connected to the tower shaft. The motor 812 can drive the motor wheel to rotate, so that the first belt 813 drives the bottom wheel 814 and the transfer shaft and the top wheel 816 connected thereto to rotate, and further the second belt 817 drives the internal gear and the tower shaft and the plurality of sample towers 700 connected thereto to rotate. Moreover, the diameter of the motor wheel is smaller than the diameter of the bottom wheel 814, and the diameter of the top wheel 816 is smaller than the diameter of the internal gear, thereby forming a two-stage speed reduction structure from the motor 812 to the tower shaft.

[0118] As an alternative embodiment of the present invention, as Figure 11 、 Figure 16 shown, the sample storage instrument 20 further includes a code scanning device 900. The code scanning device 900 can scan and read the identification code information on the sample plate 11 stored in each sample storage position c on the sample tower 700, so that the plate transfer device 100 of the pipetting instrument 10 can pick and place the sample plate 11 at the corresponding position of the sample tower 700 according to the identification code information.

[0119] As an alternative embodiment of the present invention, as Figure 11 shown, the code scanning device 900 includes a lifting module 910 and a code reader 920. The lifting module 910 can drive the code reader 920 to move in the vertical direction so that the code reader 920 corresponds to the height of each layer of sample storage positions c, and the code reader 920 can scan and read the identification code information on the sample plate 11.

[0120] As an alternative embodiment of the present invention, as Figure 16As shown in the figure, the code scanning device 900 further includes a picking and placing module 940. The picking and placing module 940 is fixedly connected to the code reader 920 and can take out the sample plate 11 stored in the sample storage positions c at various heights of the sample tower 700, or put the sample plate 11 into the sample storage position c of the sample tower 700. Thus, the plate transfer device 100 only needs to place the sample plate 11 from a fixed height into the sample storage position c at the corresponding position of the sample tower 700. After the sample storage position c where the sample plate 11 is to be placed rotates to face the code scanning device 900, the picking and placing module 940 takes out the newly placed sample plate 11 and transfers the sample plate 11 to the sample storage position c at a suitable position.

[0121] As an alternative embodiment of the present invention, as Figure 16 shown, the lifting module 910 includes a vertical guide rail 912, a code reading mounting seat 913, a lifting lead screw 914, and a lead screw driving part 915. The lifting lead screw 914 is arranged in the same direction as the vertical guide rail 912. The code reading mounting seat 913 is movably connected to the vertical guide rail 912, and the code reading mounting seat 913 has a threaded mating hole. The lifting lead screw 914 passes through the threaded mating hole. The code reader 920 is fixedly connected to the code reading mounting seat 913. The lead screw driving part 915 can drive the lifting lead screw 914 to rotate to drive the code reading mounting seat 913 to drive the code reader 920 to move in the vertical direction.

[0122] As an alternative embodiment of the present invention, as Figure 16 shown, the code scanning device 900 further includes a mounting frame 930. The mounting frame 930 includes a mounting top plate and a pair of mounting side plates. The tops of the mounting side plates are respectively fixedly connected to both ends of the mounting top plate. The bottoms of the mounting side plates are fixedly connected to the bottom wall of the housing 600. The vertical guide rail 912 is fixedly arranged on the mounting side plates. The top end of the lifting lead screw 914 passes through the mounting top plate and is connected to the lead screw driving part 915.

[0123] As an alternative embodiment of the present invention, as Figure 16 shown, the lead screw driving part 915 includes a lifting motor and a pulley transmission structure. The lifting motor is fixedly arranged on the mounting top plate, and the output shaft of the lifting motor is connected to the top end of the lifting lead screw 914 through the pulley transmission structure. The lifting motor can drive the lifting lead screw 914 to rotate through the pulley transmission structure.

[0124] As a preferred embodiment of the present invention, as Figure 10 shown, a sample inlet is formed on the housing 600 of the sample storage instrument 20, and a sealing door panel 610 is arranged at the sample inlet. The sealing door panel 610 can be pushed inward when the plate holder 130 extends into the sample inlet and automatically returns to the Figure 10 closed state of the sample inlet as shown in the figure after the plate holder 130 is retracted.

[0125] Optionally, asFigure 10 As shown, the sealing door panel 610 is hingedly connected to the housing 600 through a hinge 620, that is, the sealing door panel 610 is a revolving door. An elastic member (such as a torsion spring) is also provided at the connection between the sealing door panel 610 and the housing 600. This elastic member can drive the sealing door panel 610 to rotate to close the sample inlet through elastic force.

[0126] As a preferred embodiment of the present invention, as Figure 7 、 Figure 8 shown, the plate moving device 100 further includes a rolling structure 140. The rolling structure 140 is arranged on one side of the plate holder 130 facing its extending direction. The rolling structure 140 can rollingly contact the sealing door panel 610 when the plate holder 130 extends into the sample inlet, so as to reduce the friction between the plate moving device 100 and the sealing door panel 610 during the process of pushing the sealing door panel 610 inward, and ensure the smoothness of the sample feeding action.

[0127] Optionally, the sample storage instrument further includes a control device, which is used for each component in the sample storage instrument (such as the temperature control device 820, the rotating device 810, the picking and placing module 940, etc.).

[0128] Optionally, the control device of the sample storage instrument can also be used to communicate with the control device in the sample adding instrument 10 or directly communicate with each moving component in the sample adding instrument 10 to control the operation of the corresponding components in the sample adding instrument 10. For example, control the translation mechanism 110, the lifting mechanism 120, the liquid transfer device 310, etc. to perform corresponding actions.

[0129] Optionally, a docking plug is provided on the housing 600. When the sample storage instrument is docked with the sample adding instrument 10, the docking plug on the housing 600 can be plugged into the corresponding plug on the sample adding instrument 10, so that the control device of the sample storage instrument can communicate with the control device or each component in the sample adding instrument 10 through a cable.

[0130] As the third aspect of the present invention, a sample storage assembly is provided, as Figures 12 to 14 shown, the sample storage assembly includes the sample adding instrument 10 provided by the present invention and the sample storage instrument 20 provided by the present invention.

[0131] In the sample storage component provided by the present invention, the pipetting instrument 10 includes a plate transfer device 100 and a plate rack 200. The plate rack 200 has a plate placement position a for placing the sample plate 11 and a cover placement position b for placing the plate cover 12. The translation mechanism 110 and the lifting mechanism 120 of the plate transfer device 100 can respectively drive the plate carrier 130 to move along the first horizontal direction x and perform a lifting motion, so as to drive the plate carrier 130 to move below the plate placement position a and pass through the plate placement position a from bottom to top, and lift the sample plate 11 in the plate placement position a. Then, drive the plate carrier 130 to move below the cover placement position b and pass through the cover placement position b from bottom to top, and cover the plate cover 12 in the cover placement position b with the sample plate 11. Then, it can also drive the plate carrier 130 to extend outside the pipetting instrument 10, so as to send the covered sample plate 11 into the sample storage instrument 20 (drug sensitivity instrument). During the process of adding samples to the sample storage instrument 20, the operator only needs to place the sample plate 11 and the plate cover 12 in the plate placement position a and the cover placement position b respectively, and the entire sample addition operation can be automatically completed by the machine, thereby saving a large amount of manual operation time and improving the convenience of the sample addition operation.

[0132] As the fourth aspect of the present invention, a sample storage method is provided. The sample storage method is used for the sample storage component provided by the embodiments of the present invention. The sample storage method includes:

[0133] Step S1: Control the translation mechanism 110 of the plate transfer device 100 to drive the plate carrier 130 to move to a position corresponding to the plate placement position a, and control the lifting mechanism 120 of the plate transfer device 100 to drive the plate carrier 130 to lift and carry the sample plate 11 in the plate placement position a;

[0134] Step S2: Control the translation mechanism 110 to drive the plate carrier 130 to move to a position corresponding to the cover placement position b, and control the lifting mechanism 120 to drive the plate carrier 130 to lift the plate cover 12 in the cover placement position b, so that the plate cover 12 is covered with the sample plate 11;

[0135] Step S3: Control the translation mechanism 110 to drive the plate carrier 130 to pass through the sample inlet of the sample storage instrument and extend into the housing 600, so that the sample plate 11 enters the sample storage position c of the sample tower rack 700;

[0136] Step S4: Control the lifting mechanism 120 to drive the plate carrier 130 to perform a lifting motion and separate from the sample plate 11, and control the translation mechanism 110 to drive the plate carrier 130 to move and leave the housing 600.

[0137] Optionally, the sample storage method provided by the present invention can be applied to the control device in the pipetting instrument 10, or to the control device in the sample storage instrument 20.

[0138] Optionally, the pipetting instrument 10 includes a liquid transfer device 310 and a sample rack 320. The sample storage method further includes, before step S1:

[0139] Step S0: Control the pipetting device 310 to aspirate liquid from the sample on the sample rack 320 and drip the liquid into the sample well of the sample plate 11.

[0140] In an embodiment of the present invention, the sampler 10 further includes a pipetting device 310. The pipetting device 310 can automatically aspirate liquid from the sample placed on the sample rack 320 and complete the operation of pipetting the liquid into the sample well of the sample plate 11. The operator only needs to place the empty sample plate 11 in the plate placement position a, thereby further saving the manual operation time and improving the convenience of the pipetting operation.

[0141] Optionally, the sample storage device 20 further includes a rotating device 810. A plurality of sample towers 700 are provided on the rotating device 810. The sample storage method further includes the following steps performed before step S3:

[0142] Step S01: Control the rotating device 810 to drive the plurality of sample towers 700 to rotate so that the sample tower 700 corresponding to the first preset storage position faces the sample inlet.

[0143] As an optional implementation manner of the present invention, as Figure 16 shown, the sample storage device 20 further includes a code scanning device 900. The code scanning device 900 includes a lifting module 910, a code reader 920, and a picking and placing module 940. The lifting module 910 can drive the code reader 920 to move in the vertical direction so that the code reader 920 corresponds to the height of each layer of sample storage position c. The code reader 920 can scan and read the identification code information on the sample plate 11. The picking and placing module 940 is fixedly connected to the code reader 920 and can take out the sample plate 11 stored in the sample storage position c at each height of the sample tower 700, or put the sample plate 11 into the sample storage position c of the sample tower 700. The sample storage method further includes the following steps performed after step S4:

[0144] Step S02: Control the rotating device 810 to drive the plurality of sample towers 700 to rotate so that the sample tower 700 corresponding to the first preset storage position faces the code scanning device 900;

[0145] Step S03: Control the lifting module 910 to drive the code reader 920 to move in the vertical direction so that the code reader 920 and the picking and placing module 940 correspond to the height of the first preset storage position, and obtain the code reading and recognition result of the code reader 920;

[0146] Step S04: Control the picking and placing module 940 to take out the sample plate 11 at the first preset storage position;

[0147] Step S05: Control the rotation device 810 to drive the multiple sample towers 700 to rotate so that the sample tower 700 corresponding to the second preset storage position faces the code scanning device 900, and control the lifting module 910 to drive the code reader 920 to move in the vertical direction so that the code reader 920 and the picking and placing module 940 correspond to the height of the second preset storage position;

[0148] Step S06: Control the picking and placing module 940 to place the sample plate 11 into the second preset storage position.

[0149] In the embodiment of the present invention, the control device can control the code scanning device 900 to transfer the sample plate 11 newly placed in the first preset storage position to different second preset storage positions. Therefore, the plate transfer device 100 only needs to place the sample plate 11 from the fixed height corresponding to the first preset storage position into the sample storage position c corresponding to the sample tower 700. After the sample storage position c where the sample plate 11 to be placed rotates to face the code scanning device 900, the picking and placing module 940 takes out the newly placed sample plate 11 and transfers the sample plate 11 to the sample storage position c at a suitable position, thereby reducing the size of the sample inlet on the housing 600 in the height direction and ensuring the stability of the temperature inside the housing 600.

[0150] Optionally, the sample storage method further includes determining the second preset storage position corresponding to the code reading and recognition result of each sample plate 11 based on preset input information. It can be understood that the preset input information can be sent by the upper computer to the control device or can be manually input information. For example, the operator manually inputs information to the corresponding machine (such as the sample adding instrument 10 or the sample storage instrument 20) through an input device such as a touchpad.

[0151] Optionally, the sample storage method further includes adjusting the set temperature of the temperature control device 820 based on preset input information.

[0152] As the fifth aspect of the present invention, there is provided an electronic device, as Figure 18 shown, the electronic device includes:

[0153] One or more processors 101;

[0154] A memory 102, on which one or more computer programs are stored. When the one or more computer programs are executed by the one or more processors 101, the one or more processors 101 implement the sample storage method provided by the embodiment of the present invention.

[0155] Optionally, as Figure 18 shown, the electronic device may further include one or more I / O interfaces 103, connected between the processor 101 and the memory 102, configured to implement information interaction between the processor 101 and the memory 102.

[0156] Among them, the processor 101 is a device with data processing capabilities, including but not limited to a central processing unit (CPU), etc.; the memory 102 is a device with data storage capabilities, including but not limited to random access memory (RAM, more specifically such as SDRAM, DDR, etc.), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory (FLASH); the I / O interface (read / write interface) is connected between the processor and the memory and can realize the information interaction between the processor and the memory, including but not limited to a data bus (Bus), etc.

[0157] As Figure 18 As shown, in some embodiments of the present invention, the processor 101, the memory 102, and the I / O interface 103 are interconnected through a bus 104 and further connected to other components of the computing device.

[0158] The above is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Those skilled in the art should understand that the present invention includes but is not limited to the content described in the drawings and the above specific implementation manner. Any modification that does not deviate from the functional and structural principles of the present invention will be included in the scope of the claims.

Claims

1. A sample adding instrument, characterized in that, It includes a plate moving device (100) and a plate rack (200), wherein, the plate rack (200) has at least one plate placing position (a) and at least one lid placing position (b), and the lid placing position (b) is located on one side of the plate placing position (a) along the first horizontal direction (x); the plate moving device (100) includes a translation mechanism (110), a lifting mechanism (120) and a plate carrier (130) connected in sequence; the translation mechanism (110) can drive the lifting mechanism (120) to drive the plate carrier (130) to move along the first horizontal direction (x), so that the plate carrier (130) moves to a position corresponding to the horizontal positions of the plate placing position (a) and the lid placing position (b), and extends out of the sample adding instrument; the lifting mechanism (120) can drive the plate carrier (130) to move up and down, so that the plate carrier (130) jacks up and bears the sample plate (11) in the plate placing position (a) and the plate lid (12) in the lid placing position (b).

2. The pipetting instrument according to claim 1, wherein The plate rack (200) includes a first side rack (210) and a second side rack (220), the first side rack (210) and the second side rack (220) are respectively arranged on both sides of the plate moving device (100) along the second horizontal direction (y), and the second horizontal direction (y) intersects with the first horizontal direction (x); the first side rack (210) has a first plate placing groove (a1) and a first lid placing groove (b1), and the horizontal positions of the first plate placing groove (a1) and the first lid placing groove (b1) are distributed along the first horizontal direction (x), the second side rack (220) has a second plate placing groove (a2) and a second lid placing groove (b2), the first plate placing groove (a1) and the second plate placing groove (a2) together form the plate placing position (a), and the first lid placing groove (b1) and the second lid placing groove (b2) together form the lid placing position (b).

3. The pipetting instrument according to claim 2, wherein The first side rack (210) includes a first side plate (211), a first plate placing table (212) and a first lid placing table (213), the first plate placing table (212) and the first lid placing table (213) are both fixedly arranged on the side of the first side plate (211) facing the second side rack (220), the first plate placing groove (a1) is formed on the first plate placing table (212), and the first lid placing groove (b1) is formed on the first lid placing table (213); The second side rack (220) includes a second side plate (221), a second plate placing table (222) and a second lid placing table (223), the second plate placing table (222) and the second lid placing table (223) are both fixedly arranged on the side of the second side plate (221) facing the first side rack (210), the second plate placing groove (a2) is formed on the second plate placing table (222), and the second lid placing groove (b2) is formed on the second lid placing table (223).

4. The sampler according to claim 3, wherein The heights of the first lid placing table (213) and the second lid placing table (223) are greater than the heights of the first plate placing table (212) and the second plate placing table (222).

5. The pipetting instrument according to any one of claims 1 to 4, characterized in that, The sample adding instrument further includes a pipetting device (310) and a sample rack (320). The position of the sample rack (320) is relatively fixed with respect to the position of the plate rack (200). The pipetting device (310) includes a moving device (311) and a pipette (312). The moving device (311) can drive the pipette (312) to move to the sample rack (320) so that the pipette (312) aspirates the liquid in the sample placed on the sample rack (320), and can also drive the pipette (312) to move to the plate placement position (a) so that the pipette (312) drips the liquid into the sample wells of the sample plate (11) placed in the plate placement position (a).

6. The sampler according to any one of claims 1 to 4, characterized in that The plate moving device (100) further includes a code reading module (150). The code reading module (150) is fixedly connected to the plate carrier (130). The code reading module (150) is used to read the barcode information of the sample plate (11) located on the plate carrier (130).

7. A sample storage instrument, characterized in that, The sample storage instrument includes a housing (600) and at least one sample tower rack (700) provided in the housing (600). The sample tower rack (700) is provided in the housing (600), and there are a plurality of sample storage positions (c) distributed in the height direction in the sample tower rack (700). There is a sample inlet on the side wall of the housing (600). The sample inlet is used for the plate carrier (130) of the plate moving device (100) in the sample adding instrument according to any one of claims 1 to 6 to extend into the housing (600), place the sample plate (11) in the sample storage position (c) and take out the sample plate (11) in the sample storage position (c).

8. The sample storage device according to claim 7, characterized in that, The sample storage instrument further includes a temperature control device (820). The temperature control device (820) can heat the gas environment in the housing (600) to control the temperature inside the housing (600).

9. The sample storage instrument according to claim 7 or 8, characterized in that, The sample storage instrument further includes a rotating device (810). A plurality of the sample tower racks (700) are provided on the rotating device (810), and the rotating device (810) can drive the plurality of sample tower racks (700) to rotate so that the plurality of sample tower racks (700) are sequentially oriented towards the sample inlet.

10. A sample storage component, characterized in that, The sample storage assembly includes the sample adding instrument (10) according to any one of claims 1 to 6 and the sample storage instrument (20) according to any one of claims 7 to 9.

11. A method for storing samples, characterized in that, The sample storage method is used for the sample storage assembly according to claim 10. The sample storage method includes: Controlling the translation mechanism (110) of the plate moving device (100) to drive the plate carrier (130) to move to a position corresponding to the plate placement position (a), and controlling the lifting mechanism (120) of the plate moving device (100) to drive the plate carrier (130) to lift and carry the sample plate (11) in the plate placement position (a). Control the translation mechanism (110) to drive the plate holder (130) to move to a position corresponding to the lid placement position (b), and control the lifting mechanism (120) to drive the plate holder (130) to lift the plate lid (12) in the lid placement position (b), so that the plate lid (12) is covered with the sample plate (11); Control the translation mechanism (110) to drive the plate holder (130) to pass through the sample inlet of the sample storage instrument and extend into the housing (600), so that the sample plate (11) enters the sample storage position (c) of the sample tower (700); Control the lifting mechanism (120) to drive the plate holder (130) to move up and down and disengage from the sample plate (11), and control the translation mechanism (110) to drive the plate holder (130) to move and leave the housing (600).

12. An electronic device, characterized in that, Comprising: One or more processors; A memory storing one or more computer programs, which, when executed by the one or more processors, cause the one or more processors to implement the sample storage method according to claim 11.

Images