Nanosecond steep pulse excitation system and pulse excitation method

Through the nano-scale high-voltage pulse source and solid-state Marx-type circuit topology, combined with the closed-loop control of the impedance detection module, the problems of slow response and insufficient control accuracy of traditional Marx circuits are solved, and nanosecond-level precise triggering and safe high-frequency energy deposition are achieved.

CN120389728APending Publication Date: 2025-07-29SHANGHAI ONIKO MEDICAL TECH CO LTD

Patent Information

Application Number
CN202510475675.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-15
Publication Date
2025-07-29

AI Technical Summary

Technical Problem

Traditional Marx circuits are slow to respond and prone to aging, and cannot dynamically adjust pulse parameters, which affects the treatment effect and safety, and lacks control accuracy, making it difficult to meet the precise triggering needs of nanosecond pulses.

Method used

It adopts nano-level high-voltage pulse source and solid-state Marx-type circuit topology, combined with an impedance detection module to monitor tissue impedance in real time, forms a closed-loop control through the controller, dynamically adjusts the pulse parameters, and achieves accurate triggering of nanoseconds.

Benefits of technology

Improve the efficiency of high-voltage pulse generation, ensure effective deposition of high-frequency energy, reduce transient voltage spikes, avoid excessive ablation or insufficient treatment, and achieve dual-mode safety protection.

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Abstract

The invention discloses a nanosecond steep pulse excitation system and a nanosecond steep pulse excitation method. The nanosecond steep pulse excitation system comprises a high-voltage pulse generation module, a controller, an impedance detection module and a treatment electrode, the high-voltage pulse generation module is used for receiving a control signal monitored by the controller and outputting a high-voltage pulse to the treatment electrode; the impedance detection module comprises a measuring electrode, tissue impedance data are collected through the measuring electrode, and the impedance data are dynamically fed back to the controller; the controller dynamically adjusts parameters of the high-voltage pulse generation module according to impedance data to form closed-loop control, the Marx circuit is optimized, the high-voltage pulse generation efficiency is high, nanosecond-level accurate triggering is achieved through embedded control, effective deposition of high-frequency energy is ensured, transient voltage spikes are reduced, impedance changes are detected in real time through the impedance detection module, and the control precision is improved. The pulse width or amplitude is dynamically adjusted, pulse parameters are adjusted in real time based on impedance changes, and excessive ablation or insufficient treatment is avoided.
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Description

Technical Field

[0001] The present invention relates to the technical field of pulse control, and particularly relates to a nanosecond steep pulse excitation system and a pulse excitation method. Background Art

[0002] A nanosecond pulse power supply is a power supply device used to generate nanosecond-level pulses. It is mainly used to drive applications such as nanosecond pulse lasers, high-speed pulse generators, and high-speed switches to generate electrical signals with high energy and short pulse widths. Nanosecond pulse power supplies are widely used in fields such as lasers, radars, high-speed pulse generators, and high-speed switches. They can provide stable, high-power nanosecond-level pulse signals to meet the working requirements of devices and systems with high-speed and high-energy requirements.

[0003] In the Chinese patent with the publication number CN 105487455A, a DSP controller for a nanosecond-level high-voltage pulse power supply is mentioned. The hardware includes a core control unit, a clock module, a random access memory, a parameter calendar module, an EEPROM module, a programming port JTAG, a three-phase synchronous signal detection module, a three-phase thyristor trigger module, an IGBT drive module, several analog quantity acquisition circuits, several digital quantity input circuits, several digital quantity output circuits, and several communication interface circuits. The present invention solves problems such as the control, monitoring, information feedback, and fault handling of a nanosecond-level high-voltage pulse power supply, and increases the reliability of the control system: through precise control of steps such as the acquisition, calculation, feedback, and adjustment of digital quantities, together with a high-precision sampling signal, a highly reliable feedback loop, and a fast-response software system, the response speed and reliability of the fault alarm system are improved, and the possibility of false alarms is reduced;

[0004] However, the traditional Marx circuit relies on mechanical switches, has a slow response and is prone to aging, resulting in low efficiency of high-voltage pulse generation; it cannot dynamically adjust pulse parameters according to tissue impedance changes, affecting the treatment effect and safety, and the control accuracy is insufficient: embedded closed-loop control is not achieved, it is difficult to meet the precise triggering requirements of nanosecond-level pulses, and a too long rise time will cause ineffective energy output, affect the safe aging of the equipment, and also affect the treatment effect and safety; overshoot will also affect the safety of the equipment and the human body. Summary of the Invention

[0005] To solve the above technical problems, the present invention provides a nanosecond steep pulse excitation system, including a high-voltage pulse generation module, a controller, an impedance detection module, and a treatment electrode;

[0006] The high-voltage pulse generation module is used to receive the control signal monitored by the controller and output a high-voltage pulse to the treatment electrode; the impedance detection module includes a measurement electrode, which is used to collect tissue impedance data and dynamically feedback the impedance data to the controller; the controller is used to dynamically adjust the parameters of the high-voltage pulse generation module according to the impedance data to form a closed-loop control.

[0007] Preferably: The high-voltage pulse generation module is a nanoscale high-voltage pulse source based on magnetic isolation drive, including a solid-state switch array and a high-voltage capacitor bank, and the nanoscale high-voltage pulse source adopts a solid-state Marx-type circuit topology.

[0008] Preferably: The solid-state Marx-type circuit topology includes a Marx generator and a magnetic isolation drive, and the Marx generator is composed of a high-voltage capacitor bank and a solid-state switch array; the magnetic isolation drive is used to achieve electrical isolation between high-voltage and low-voltage circuits.

[0009] Preferably: The solid-state switch structure is a solid-state switch structure adopting N-stage parallel charging and series discharging.

[0010] Preferably: It also includes an RC buffer circuit, which is arranged between the solid-state switch structures and is connected to the solid-state switch structures.

[0011] Preferably: The controller includes a field-programmable gate array, an ARM processor, a real-time operating system, and an HMI interface. Preferably, the HMI interface is used to connect to an HMI serial screen, and the user can set target pulse parameters through the HMI serial screen.

[0012] Preferably: The impedance detection module is used to monitor the impedance of the treatment area in real time to obtain the impedance amplitude and phase angle. Preferably, the impedance detection module includes an AC excitation source, a differential amplifier circuit, and a phase detection circuit, and is used to identify whether the cell membrane is broken down through impedance amplitude and phase angle analysis.

[0013] Preferably, the AC excitation source includes a sine wave generator and a voltage-controlled amplifier, which are used to generate a multi-frequency signal and inject it into the tissue through the treatment electrode. The sine wave generator uses the non-linear characteristics of the amplifier and the feedback loop to generate self-excited oscillation, and realizes the output of the sine wave by adjusting the feedback network.

[0014] Preferably: The impedance amplitude range is |Z|±2%; the phase angle range is θ±0.5°. When the impedance suddenly drops >20%, it is determined that the cell membrane is broken down.

[0015] Preferably: The treatment electrode also includes a safety protection module, which is used for overvoltage or overcurrent protection during the pulse output process. Preferably, the treatment electrode includes a contact detection sensor and an ablation electrode, and the ablation electrode is the discharge electrode.

[0016] A pulse excitation method, comprising the following steps:

[0017] The Marx module receives a control signal and outputs a high-voltage pulse to the treatment electrode;

[0018] The impedance detection module collects tissue impedance data through the measurement electrode and feeds it back to the controller;

[0019] The controller dynamically adjusts the high-voltage pulse parameters output by the Marx module according to the impedance data to form a closed-loop control.

[0020] Preferably, when the controller dynamically adjusts the high-voltage pulse parameters output by the Marx module according to the impedance data, it judges whether the current impedance Z is less than the Z threshold. If so, after reducing the pulse amplitude △V, it outputs the pulse and monitors the temperature; if not, it continues to judge whether the Z change rate is greater than 20%. If so, it shortens the pulse width △T, outputs the pulse and monitors the temperature; if not, it maintains the current parameters, outputs the pulse and monitors the temperature, and feeds it back to the controller.

[0021] The technical effects and advantages of the present invention:

[0022] 1. The present invention optimizes the Marx circuit, has a high high-voltage pulse generation efficiency, realizes nanosecond-level precise triggering through embedded control, ensures effective deposition of high-frequency energy, and reduces transient voltage spikes.

[0023] 2. In the present invention, an impedance detection module is adopted to detect impedance changes in real time, dynamically adjust the pulse width or amplitude, and adjust the pulse parameters in real time based on impedance changes to avoid over-ablation or insufficient treatment.

[0024] 3. The pulse excitation method of the present invention adopts a dual-mode operation and a multi-modal safety protection mechanism to prevent the risks of overheating or non-contact discharge. Description of the Drawings

[0025] Figure 1 is the overall architecture block diagram of the nanosecond steep pulse excitation system provided by the embodiment of the present application;

[0026] Figure 2 is the pulse waveform parameter diagram in the nanosecond steep pulse excitation system provided by the embodiment of the present application;

[0027] Figure 3 is the Marx circuit topology diagram in the nanosecond steep pulse excitation system provided by the embodiment of the present application;

[0028] Figure 4 is the switch drive timing diagram in the nanosecond steep pulse excitation system provided by the embodiment of the present application;

[0029] Figure 5 is the circuit principle of the impedance detection module in the nanosecond steep pulse excitation system provided by the embodiment of the present application;

[0030] Figure 6 It is the flowchart of the adaptive adjustment of pulse parameters in the nanosecond steep pulse excitation method provided by the embodiments of the present application. Specific embodiments

[0031] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. The embodiments of the present invention are given for purposes of illustration and description, and are not exhaustive or limit the present invention to the disclosed form. Many modifications and variations are obvious to those of ordinary skill in the art. The embodiments are selected and described to better illustrate the principles and practical applications of the present invention, and enable those of ordinary skill in the art to understand the present invention and design various embodiments with various modifications suitable for specific purposes.

[0032] Please refer to Figure 1 , in this embodiment, a nanosecond steep pulse excitation system is provided, including a Marx pulse generation module (high-voltage pulse generation module), a controller, an impedance detection module, and a treatment electrode;

[0033] The high-voltage pulse generation module is used to receive the control signal monitored by the controller and output a high-voltage pulse to the treatment electrode; the impedance detection module includes a measurement electrode, and the measurement electrode is used to collect tissue impedance data and dynamically feedback the impedance data to the controller; the controller is used to dynamically adjust the parameters of the high-voltage pulse generation module according to the impedance data to form a closed-loop control.

[0034] Specifically, the user sets the target pulse parameters through the human-machine interface, the impedance detection module is initialized, the tissue baseline impedance before treatment is measured, the high-voltage pulse generation module automatically matches the initial voltage according to the baseline impedance, during the pulse output process, the impedance change is detected in real time, the pulse width or amplitude is dynamically adjusted, if an impedance mutation is detected, protection is triggered and the output is paused, and the pulse parameters are adjusted in real time based on the impedance change to avoid the occurrence of over-ablation or under-treatment.

[0035] In a specific embodiment, the high-voltage pulse generation module adopts a solid-state Marx circuit topology, including a Marx generator and a magnetic isolation drive. The use of a magnetic isolation drive can achieve electrical isolation between the high-voltage and low-voltage circuits; the Marx generator consists of a high-voltage capacitor bank and a solid-state switch array, and adopts a solid-state switch structure of N-level parallel charging and series discharging. During the charging process, each capacitor is charged in parallel and the voltage gradually increases; when the set threshold is reached, the gas switch conducts, and each capacitor discharges in series to generate a high-voltage pulse output.

[0036] The energy storage capacitors in the high-voltage capacitor bank, with a capacitance of C = 100 μF for each stage, a rated voltage of Vrated = 5 kV, and the total output voltage Vout = N × Vcap, meet the 15 kV requirement to achieve a 15 kV high-voltage output. The pulse rise time ≤ 10 ns, and the inter-stage synchronization error ≤ 0.5 ns, ensuring effective deposition of high-frequency energy and reducing transient voltage spikes.

[0037] Among them, the switching delay of the switching devices in the solid-state switch array < 5 ns, and the withstand voltage V br ≥ 10 V.

[0038] Preferably, high-speed IGBTs (Insulated Gate Bipolar Transistors) are used, adopting the IXYS (Isys GmbH) series or MOSFETs (Metal Oxide Semiconductor Field Effect Transistors);

[0039] Synchronous triggering: Generate PWM signals with precise timing through an embedded system to ensure synchronous conduction of each stage of switches and avoid pulse distortion.

[0040] It can be understood that a multi-stage solid-state switch (such as MOSFET or IGBT) with a parallel charging and series discharging structure is adopted. The charging voltage and discharging timing are adjusted by a controller. Its pulse width: ≥ 10 ns, voltage: 1 kV - 20 kV, repetition frequency: 1 kHz - 10 kHz.

[0041] Furthermore, to optimize the problem of pulse overcharging, the coupling isolation drive in the Marx circuit uses a coupling isolator to drive the switch, avoiding magnetic loop interference and improving switch synchronization;

[0042] Refer to Figure 2 As shown, it also includes an RC buffer circuit, which is set between the solid-state switch structures and connected to the solid-state switch structures. The parameters of the RC buffer circuit are R = 10 Ω and C = 1 nF, suppressing transient voltage spikes, avoiding overshoot, reducing switch losses, and improving treatment safety.

[0043] Refer to Figure 3 As shown, when N = 3, it is a three-stage Marx circuit, and each stage includes switch S1, switch S2, switch S3, and capacitor C1, capacitor C2, and capacitor C3.

[0044] In the charging stage, switches S1, S2, and S3 conduct in parallel, and capacitors C1, C2, and C3 are charged to the same voltage V_charge;

[0045] In the discharging stage, switches S1, S2, and S3 conduct in series, and capacitors C1, C2, and C3 output a superimposed high voltage, V_out = 3 × V_charge.

[0046] Refer to Figure 4The shown switch drive timing diagram triggers the switches in the order of S1 → S2 → S3, with an interval of 100 ns, ensuring the synchronization of series discharge.

[0047] In a specific embodiment, the controller includes an FPGA (Field Programmable Gate Array), an ARM processor, a Real-Time Operating System (RTOS), and an HMI interface. Among them, the FPGA is a further developed product based on devices such as Programmable Array Logic (PAL), Generic Array Logic (GAL), Erasable Programmable Logic Device (EPLD), etc. It is a programmable logic chip that can perform general functions, that is, it can be programmed to implement a certain logic processing function.

[0048] The ARM processor and RTOS (Real-Time Operating System), RTOS is an operating system specifically designed to process tasks within a specified time. The main feature of RTOS is that it can quickly accept and process these events when external events or data occur, ensuring that operations are completed within the specified time, thereby controlling the production process or making a quick response to the system.

[0049] The HMI interface is used to connect to the HMI serial screen, and users can set target pulse parameters through the HMI serial screen.

[0050] It can achieve the following functions:

[0051] For parameter configuration: digitally set parameters such as pulse amplitude, pulse width, frequency, etc., and support GUI or remote control;

[0052] For real-time monitoring: collect the voltages of each node of the Marx circuit, with the voltage accuracy of ±0.5%, and the current signal accuracy of ±1% accuracy, so as to detect abnormal states;

[0053] For dynamic adjustment: based on impedance detection data, such as changes in tissue conductivity, adaptively adjust output parameters, such as increasing the voltage to break through the cell membrane, using dynamic impedance detection and real-time tuning, matching a 50 - 200 Ω biological tissue load, and the energy reflectivity < 5%.

[0054] Specifically, using the FPGA core can achieve nanosecond-level timing control, ensuring that the switch synchronization error < 5 ns; using the ARM processor: running RTOS, processing algorithms and data communication; implementing closed-loop control, using the PID (Proportional-Integral-Derivative) algorithm to dynamically adjust the charging voltage and discharge timing, compensating for load changes; implementing fault diagnosis, triggering the protection mechanism based on threshold comparison (such as overcurrent > 50 A), and the response time < 10 μs.

[0055] Refer to Figure 5As shown, in a specific embodiment, the impedance detection module is used to monitor the impedance of the treatment area in real time. The impedance detection module measures the tissue impedance to obtain the impedance amplitude and phase angle. The impedance detection module includes an AC excitation source, a differential amplifier circuit, and a phase detection circuit. The tissue impedance range is 10Ω - 10kΩ, and the frequency is 10kHz - 1MHz. Through the analysis of the impedance amplitude and phase angle, it is used to identify whether the cell membrane is broken down.

[0056] Among them, the impedance amplitude range is |Z| ± 2%, and the phase angle range is θ ± 0.5°. When the impedance suddenly drops > 20%, it is determined that the cell membrane is broken down.

[0057] Specifically, the AC excitation source includes a sine wave generator and a voltage-controlled amplifier, which is used to generate multi-frequency signals and inject them into the tissue through the treatment electrode. The sine wave generator uses the non-linear characteristics of the amplifier and the feedback loop to generate self-excited oscillation, and realizes the output of the sine wave by adjusting the feedback network. This type of oscillator has a simple structure and a wide frequency range; the voltage-controlled amplifier uses a voltage-controlled resistor to adjust the amplification factor of the amplifier, so as to achieve the purpose of adjusting the output voltage and improve the measurement accuracy.

[0058] The differential amplifier circuit includes a differential amplifier and a band-pass filter. Both the differential amplifier and the band-pass filter are connected to the positive electrode and the negative electrode of the electrode. The differential amplifier is used to collect the voltage across the electrode, amplify the differential signal, and suppress the common-mode noise; the band-pass filter is used to select signals in a specific frequency range, filter out high-frequency switching noise, and suppress interference from other frequencies, such as Marx pulse interference.

[0059] The phase detection circuit includes a multiplier and a low-pass filter. The multiplier multiplies the modulation signal and the carrier signal to generate new signals with frequencies that are the sum and difference of the modulation signal frequency and the carrier signal frequency. Then, the high-frequency components in the new signals are filtered out through the low-pass filter to obtain the original modulation signal. The multiplier combines the reference signal for phase-sensitive detection to extract the real part / imaginary part of the impedance.

[0060] The AC excitation source uses an excitation electrode to inject high-frequency alternating current during monitoring to avoid polarization effects; the phase detection circuit uses a measurement electrode to detect the voltage signal, which is amplified by the differential amplifier and then input into the ADC module (analog-to-digital converter); after signal processing, through digital demodulation, the impedance amplitude (|Z|) and phase (θ) are extracted through the FFT (Fast Fourier Transform) algorithm; the sampling rate is ≥ 1MSPS (data volume transmitted per second is 1 megabit); the system error is automatically corrected through a reference resistor (such as 1kΩ ± 0.1%) to achieve dynamic calibration.

[0061] It can be understood that using a differential amplifier can suppress common-mode interference and extract impedance signals.

[0062] During use, an AC excitation source generates a multi-frequency excitation signal. The signal amplified by the differential amplifier circuit is transmitted to the phase detection circuit. The demodulated DC voltage is transmitted to the ADC module. After extracting the impedance data, it is fed back to the controller. The controller dynamically adjusts the Marx parameters according to the impedance data to form a closed-loop control.

[0063] In a specific embodiment, the treatment electrode includes a contact detection sensor and an ablation electrode. The ablation electrode is a discharge electrode. During energy transfer, a high-voltage pulse is accurately applied to the target tissue through the discharge electrode. The controller feeds back a safety protection signal to the treatment electrode to achieve electrical isolation, overvoltage / overcurrent protection, and contact state monitoring.

[0064] Specifically, the contact state between the electrode and the tissue is judged by impedance measurement. If there is no contact, the pulse output is prohibited.

[0065] Furthermore, the treatment electrode also includes a safety protection module. During the pulse output process, the safety protection module is used for overvoltage or overcurrent protection. The safety protection module adopts an optical fiber isolator. By using the method of optical fiber or multi-stage hybrid isolation between the high-voltage side and the low-voltage side, high voltage resistance is achieved; methods such as TVS diodes, varistors, gas discharge tubes, or self-resetting fuses are used to achieve overvoltage protection, and its response time is <1 ns; sensors such as Hall sensors, magnetoresistive sensors, or inductive sensors are used to trigger a solid-state relay (SSR) to cut off the circuit to achieve overcurrent protection, and its action time is <10 μs.

[0066] In the present invention, the Marx circuit is optimized to achieve nanosecond-level precise triggering through embedded control; the pulse parameters are adjusted in real time based on impedance changes to avoid over-ablation or insufficient treatment, and impedance dynamic feedback is achieved; it supports a fixed parameter mode (manually set by the doctor) and an adaptive mode to achieve dual-mode operation.

[0067] Refer to Figure 6 As shown, in another embodiment, a pulse excitation method is provided, including the following steps:

[0068] The Marx module receives a control signal and outputs a high-voltage pulse to the treatment electrode;

[0069] The impedance detection module collects tissue impedance data through the measurement electrode and feeds it back to the controller;

[0070] The controller dynamically adjusts the high-voltage pulse parameters output by the Marx module according to the impedance data to form a closed-loop control.

[0071] Specifically, it includes the following steps:

[0072] Initialize the treatment parameters. The user sets the target pulse parameters through the man-machine interface. The high-voltage pulse generation module automatically matches the initial voltage according to the baseline impedance and outputs a high-voltage pulse to the treatment electrode;

[0073] The impedance detection module is started. The impedance detection module collects tissue impedance data through the measurement electrode, such as measuring the tissue baseline impedance before treatment;

[0074] Obtain the current impedance Z. During the pulse output process, detect the impedance change in real time and dynamically adjust the pulse width or amplitude;

[0075] Judge whether the current impedance Z is less than the Z threshold value. If so, after reducing the pulse amplitude △V, output the pulse and monitor the temperature; if not, continue to judge whether the Z change rate is greater than 20%. If so, shorten the pulse width △T, output the pulse and monitor the temperature; if not, maintain the current parameters, output the pulse and monitor the temperature, and feedback to the controller;

[0076] Continuous safety protection. Judge whether the temperature is higher than the threshold value or the impedance has mutated; if the temperature is higher than the threshold value or the impedance has mutated, stop emergently; if the temperature is not higher than the threshold value or the impedance has not mutated, continue the treatment. The controller dynamically adjusts the high-voltage pulse parameters output by the Marx module according to the impedance data, and judges whether the treatment time exceeds the limit. If so, stop emergently, if not, return to the step of starting the impedance detection module.

[0077] In this nanosecond steep pulse excitation method, by judging the impedance threshold value, if the impedance is lower than the baseline, the voltage is reduced to avoid excessive ablation, where the baseline is the baseline impedance for cell membrane breakdown.

[0078] By judging the impedance change rate, when the impedance drops rapidly, the pulse width is shortened to prevent heat accumulation and improve the safety of the treatment.

[0079] Multi-modal safety protection mechanism. By judging the double thresholds of temperature and impedance, prevent the risks of overheating or non-contact discharge, trigger the emergency stop function, and ensure the treatment safety.

[0080] Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art and related fields without creative work shall fall within the protection scope of the present invention. The structures, devices, and operation methods not specifically described and explained in the present invention, unless otherwise specified and limited, are implemented according to the conventional means in the art.

Claims

1. A nanosecond steep pulse excitation system, characterized in that, It includes a high-voltage pulse generation module, a controller, an impedance detection module, and a treatment electrode; The high-voltage pulse generation module is used to receive the control signal monitored by the controller and output a high-voltage pulse to the treatment electrode; The impedance detection module includes measurement electrodes, which are used to collect tissue impedance data and dynamically feedback the impedance data to the controller; The controller is used to dynamically adjust the parameters of the high-voltage pulse generation module according to the impedance data to form a closed-loop control.

2. The nanosecond steep pulse excitation system according to claim 1, wherein The high-voltage pulse generation module is a nanoscale high-voltage pulse source based on magnetic isolation drive, including a solid-state switch array and a high-voltage capacitor bank. The nanoscale high-voltage pulse source adopts a solid-state Marx circuit topology.

3. The nanosecond steep pulse excitation system according to claim 2, wherein, The solid-state Marx circuit topology includes a Marx generator and a magnetic isolation drive. The Marx generator consists of a high-voltage capacitor bank and a solid-state switch array; the magnetic isolation drive is used to achieve electrical isolation between the high-voltage and low-voltage circuits.

4. A nanosecond steep pulse excitation system according to claim 3, characterized in that The solid-state switch structure is a solid-state switch structure using N-stage parallel charging and series discharging.

5. A nanosecond steep pulse excitation system according to claim 1, characterized in that, It also includes an RC buffer circuit, which is arranged between the solid-state switch structures and connected to the solid-state switch structures.

6. The nanosecond steep pulse excitation system according to claim 1, characterized in that, The controller includes a field-programmable gate array, an ARM processor, a real-time operating system, and an HMI interface. Preferably, the HMI interface is used to connect to an HMI serial screen, and the user sets the target pulse parameters through the HMI serial screen.

7. A nanosecond steep pulse excitation system according to claim 1, characterized in that, The impedance detection module is used to monitor the impedance of the treatment area in real time to obtain the impedance amplitude and phase angle. Preferably, the impedance detection module includes an AC excitation source, a differential amplification circuit, and a phase detection circuit, which are used to identify whether the cell membrane is broken down through impedance amplitude and phase angle analysis.

8. A nanosecond steep pulse excitation system according to claim 7, characterized in that The AC excitation source includes a sine wave generator and a voltage-controlled amplifier, which are used to generate a multi-frequency signal and inject it into the tissue through the treatment electrode. The sine wave generator uses the non-linear characteristics of the amplifier and the feedback loop to generate self-excited oscillation, and realizes the output of the sine wave by adjusting the feedback network.

9. A nanosecond steep pulse excitation system according to claim 7, wherein The impedance amplitude range is |Z|±2%; the phase angle range is θ±0.5°. When the impedance suddenly drops >20%, it is determined that the cell membrane is broken down.

10. The nanosecond steep pulse excitation system according to claim 1, wherein The treatment electrode further includes a safety protection module, which is used for overvoltage or overcurrent protection during the pulse output process; Preferably, the treatment electrode includes a contact detection sensor and an ablation electrode, and the ablation electrode is a discharge electrode.

11. A nanosecond steep pulse excitation method according to any one of claims 1-10, characterized in that, It includes the following steps: The Marx module receives the control signal and outputs a high-voltage pulse to the treatment electrode; The impedance detection module collects tissue impedance data through the measurement electrodes and feeds it back to the controller; The controller dynamically adjusts the high-voltage pulse parameters output by the Marx module according to the impedance data to form a closed-loop control.

12. A nanosecond steep pulse excitation method according to claim 10, wherein The controller dynamically adjusts the high-voltage pulse parameters output by the Marx module according to the impedance data, determines whether the current impedance Z is less than the Z threshold. If so, after reducing the pulse amplitude △V, it outputs a pulse and monitors the temperature; if not, it continues to determine whether the Z change rate is greater than 20%. If so, it shortens the pulse width △T, outputs a pulse and monitors the temperature; if not, it maintains the current parameters, outputs a pulse and monitors the temperature, and feeds back to the controller.

Citation Information

Patent Citations

  • High-frequency composite electric field ablation system

    CN113633370A

  • Diode-directed solid-state marx generator

    US20060245217A1

  • High-voltage analog circuit pulser with feedback control

    US20170245928A1

  • Ablation system

    US20250025222A1

  • Configurable pulse generator

    WO2011146498A2

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