Infant formula milk powder and preparation method thereof

Abstract

The invention discloses infant formula milk powder and a preparation method thereof. Comprising 0-6-month-old formula milk powder, 6-12-month-old formula milk powder and 12-36-month-old formula milk powder. The infant formula milk powder fits the natural growth curve of babies by adjusting the proportion of whey protein and casein at different segments. The baby feed is rich in nutrition, can promote development and growth of babies and has strong antibacterial property. The 0-6-month-old formula milk powder contains casein phosphopeptides and 3 '-sialyllactose, and can promote the growth and development of infants; the 6-12-month-old formula milk powder contains various probiotics and prebiotics, so that the antibacterial ability of the infants is improved; the 12-36-month-old formula milk powder contains L-carnitine tartrate and a milk fat globule membrane, so that the intestinal leakage prevention capability of infants is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of infant foods, and particularly relates to infant formula milk powder and a preparation method thereof. Background Art

[0002] Infant formula is a breast milk substitute designed for infants who cannot breastfeed. Its ingredients closely mimic the nutritional composition of breast milk. Infant formula is generally divided into three stages. Stage 1 (0-6 months): The formula is closer to breast milk, with a moderate protein content, easy digestion and absorption, and contains a variety of essential amino acids, fatty acids (such as DHA and ARA), minerals, and vitamins similar to the nutritional composition of breast milk to meet the rapid growth and development needs of babies at this stage. Stage 2 (6-12 months): The content of protein, fat, minerals, and other ingredients is adjusted to meet the baby's changing nutritional needs at this stage, and some nutrients are added to support the baby's intellectual development and bone growth. Stage 3 (12-36 months): Further nutrients are added to support the baby's intellectual development and bone growth.

[0003] As a substitute for breast milk, infant formula has made significant progress in nutrition and safety, but some potential flaws or controversial points still exist, mainly including the following aspects: 1. Limitations of nutritional formula and differences from breast milk: Breast milk contains active immune components (such as antibodies, enzymes, probiotics), growth factors, and dynamically changing nutrients, which are difficult to fully replicate in formula. Although formula is supplemented with DHA, ARA, nucleotides, etc., the bioavailability and synergistic effects may not be as good as breast milk. Individual adaptability differences: Some infants may be intolerant to the protein (such as the whey protein / casein ratio), lactose, or added ingredients (such as prebiotics) in formula, leading to diarrhea, flatulence, or allergies. 2. Poor antibacterial properties. Infants infected with pathogenic bacteria are prone to various diseases. Compared with breast milk, current infant formula has poorer antibacterial properties. 3. Infants: Leaky gut syndrome (increased intestinal permeability) is a highly discussed yet controversial concept. It refers to a compromised intestinal barrier function, allowing undigested food particles, toxins, and bacteria to pass through the intestinal wall and enter the bloodstream, potentially triggering allergic, inflammatory, or immune responses. Infants with leaky gut experience recurrent diarrhea, bloating, bloody stools, and constipation (possibly accompanied by mucus), impacting their growth and development. Summary of the Invention

[0004] The object of the present invention is to provide an infant formula milk powder and a preparation method thereof.

[0005] Disclosed is infant formula milk powder, comprising formula milk powder for infants aged 0-6 months, formula milk powder for infants aged 6-12 months, and formula milk powder for infants aged 12-36 months; the formula milk powder for infants aged 0-6 months comprises casein phosphopeptide and 3'-sialyllactose; the formula milk powder for infants aged 6-12 months comprises Bifidobacterium longum subsp. infantis CCFM1192 and Lactobacillus reuteri SS23-52; and the formula milk powder for infants aged 12-36 months comprises L-carnitine tartrate and milk fat globule membrane.

[0006] The Bifidobacterium longum subsp. infantis CCFM1192 was purchased from Guangdong Provincial Microbiological Culture Collection Center with a collection number of GDMCC No. 61846; the Lactobacillus reuteri SS23-52 was purchased from China General Microbiological Culture Collection Center (CGMCC) with a collection number of CGMCC No. 15152.

[0007] The 0-6 month formula milk powder is composed of the following components in parts by weight: 500-900 parts of high-oil desalted whey powder, 0-200 parts of whole milk powder, 1-100 parts of whey protein powder, 10-50 parts of polyfructose, 1-20 parts of casein phosphopeptide, 0.01-5 parts of 3'-sialyllactose, 1-10 parts of arachidonic acid oil, 1-10 parts of docosahexaenoic acid oil, 0.01-1 parts of inositol, 0.1-1 parts of nucleotides, 0.1-1 parts of L-carnitine tartrate, 0.01-1 parts of lutein, and 0.01-1 parts of taurine.

[0008] The formula milk powder for children aged 6 to 12 months is composed of the following components in parts by weight: 500-900 parts of high-oil desalted whey powder, 50-200 parts of whole milk powder, 50-200 parts of skim milk powder, 1-100 parts of whey protein powder, 1-10 parts of arachidonic acid oil, 1-10 parts of docosahexaenoic acid oil, 0.01-1 part of inositol, 0.01-1 part of nucleotides, 0.01-1 part of L-carnitine tartrate, 0.01-1 part of lutein, 0.01-1 part of taurine, 0.01-2 parts of Bifidobacterium longum infantis subspecies CCFM1192, and 0.01-1 part of Lactobacillus reuteri SS23-52.

[0009] The formula milk powder for babies aged 12-36 months is composed of the following components in parts by weight: 400-800 parts of high-oil desalted whey powder, 50-200 parts of whole milk powder, 50-200 parts of skim milk powder, 1-100 parts of whey protein powder, 1-10 parts of arachidonic acid oil, 1-10 parts of docosahexaenoic acid oil, 0.01-1 parts of inositol, 0.01-1 parts of nucleotides, 1-10 parts of milk fat globule membrane, 0.01-1 parts of L-carnitine tartrate, 0.01-1 parts of lutein, 0.01-1 parts of taurine, 0.01-1 parts of animal Bifidobacterium lactis subspecies HN019, and 0.01-1 parts of animal Bifidobacterium lactis subspecies Bi-07.

[0010] The high-oil desalted whey powder is prepared from the following components in parts by weight: 300-600 parts of desalted whey, 100-150 parts of cream, 100-150 parts of vegetable blending oil, 10-20 parts of phospholipids, and 3-8 parts of sodium ascorbate.

[0011] The vegetable blended oil is composed of the following components in parts by weight: 30-50 parts of soybean oil, 25-30 parts of sunflower oil, 20-30 parts of low-erucic acid rapeseed oil, 20-30 parts of coconut oil, 1-3 parts of mixed tocopherol concentrate, and 1-3 parts of ascorbyl palmitate.

[0012] Minerals and vitamins are added to the 0-6 month formula milk powder, 6-12 month formula milk powder and 12-36 month formula milk powder, and the added amount accounts for 0.01-1% of the total weight of the formula milk powder.

[0013] The minerals are one or more of calcium chloride, potassium chloride, tricalcium phosphate, magnesium sulfate, ferrous sulfate, zinc lactate, copper sulfate, manganese sulfate, potassium iodate, and sodium selenite.

[0014] The vitamins are one or more of L-sodium ascorbate, dl-α-tocopheryl acetate, niacinamide, D-calcium pantothenate, thiamine hydrochloride, retinyl acetate, pyridoxine hydrochloride, folic acid, phytonadione, D-biotin, cholecalciferol, cyanocobalamin, riboflavin, and choline bitartrate.

[0015] The beneficial effects of this invention include: The infant formula milk powder is nutritious, promotes infant development and growth, and has strong antibacterial properties. The formula milk powder for infants aged 0-6 months contains casein phosphopeptides and 3'-sialyllactose, which promote growth and development; the formula milk powder for infants aged 6-12 months contains Bifidobacterium longum subsp. infantis CCFM1192 and Lactobacillus reuteri SS23-52, which enhances antibacterial properties; and the formula milk powder for infants aged 12-36 months contains L-carnitine tartrate and milk fat globule membrane, which enhances intestinal leakiness. DETAILED DESCRIPTION

[0016] To facilitate understanding of the present invention, the present invention will be described more fully below. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive. Example 1

[0017] A baby formula milk powder, comprising a 0-6 month formula milk powder, a 6-12 month formula milk powder and a 12-36 month formula milk powder; the 0-6 month formula milk powder is composed of the following components in parts by weight: 700 parts of high-oil desalted whey powder, 100 parts of whole milk powder, 50 parts of whey protein powder, 30 parts of polyfructose, 12 parts of casein phosphopeptide, 3 parts of 3'-sialyllactose, 5 parts of arachidonic acid oil, 5 parts of docosahexaenoic acid oil, 0.05 parts of inositol, 0.5 parts of nucleotides, and L-carnitine tartrate. 0.3 parts, lutein 0.05 parts, taurine 0.04 parts; the 6-12 month formula milk powder is composed of the following components in parts by weight: 700 parts of high oil desalted whey powder, 100 parts of whole milk powder, 100 parts of skim milk powder, 50 parts of whey protein powder, 5 parts of arachidonic acid oil, 5 parts of docosahexaenoic acid oil, 0.03 parts of inositol, 0.07 parts of nucleotides, 0.06 parts of L-carnitine tartrate, 0.02 parts of lutein, 0.02 parts of taurine, Bifidobacterium longum infantis subspecies CCFM1192 1 part and 0.5 parts of Lactobacillus reuteri SS23-52; the 12-36 month formula milk powder is composed of the following components in parts by weight: 600 parts of high-oil desalted whey powder, 100 parts of whole milk powder, 100 parts of skim milk powder, 50 parts of whey protein powder, 3 parts of arachidonic acid oil, 6 parts of docosahexaenoic acid oil, 0.04 parts of inositol, 0.05 parts of nucleotides, 5 parts of milk fat globule membrane, 0.2 parts of L-carnitine tartrate, 0.3 parts of lutein, 0.3 parts of taurine, 0.6 parts of animal Bifidobacterium lactis subspecies HN019, and 0.6 parts of animal Bifidobacterium lactis subspecies Bi-07.

[0018] The high-oil desalted whey powder is prepared from the following components in parts by weight: 450 parts of desalted whey, 120 parts of cream, 120 parts of vegetable blending oil, 15 parts of phospholipids, and 6 parts of sodium ascorbate; the vegetable blending oil is composed of the following components in parts by weight: 40 parts of soybean oil, 28 parts of sunflower oil, 24 parts of low-erucic acid rapeseed oil, 24 parts of coconut oil, 2 parts of mixed tocopherol concentrate, and 2 parts of ascorbyl palmitate.

[0019] Minerals and vitamins are also added to the 0-6 month formula milk powder, and the added amounts are 0.015% and 0.025% of the total weight of the 0-6 month formula milk powder, respectively; the minerals and the percentage of the total weight of the 0-6 month formula milk powder are calcium chloride 0.003%, potassium chloride 0.003%, tricalcium phosphate 0.0015%, magnesium sulfate 0.001%, ferrous sulfate 0.002%, zinc lactate 0.0015%, copper sulfate 0.001%, manganese sulfate 0.001%, potassium iodate 0.0005%, sodium selenite 0.001%. .0005%; the vitamins and their percentage by weight of the total formula milk powder for 0-6 months of age are 0.003% L-sodium ascorbate, 0.003% niacinamide, 0.003% D-calcium pantothenate, 0.001% thiamine hydrochloride, 0.003% retinyl acetate, 0.001% pyridoxine hydrochloride, 0.005% folic acid, 0.001% phytonadione, 0.001% D-biotin, 0.001% cholecalciferol, 0.001% cyanocobalamin, 0.001% riboflavin, and 0.001% choline bitartrate.

[0020] The 6-12 month formula milk powder further contains minerals and vitamins, the added amounts of which are 0.02% and 0.02% of the total weight of the 6-12 month formula milk powder respectively; the minerals and the percentage of the total weight of the 6-12 month formula milk powder are as follows: calcium chloride 0.005%, potassium chloride 0.005%, tricalcium phosphate 0.0015%, magnesium sulfate 0.002%, ferrous sulfate 0.002%, zinc lactate 0.0015%, copper sulfate 0.001%, manganese sulfate 0.001%, potassium iodate 0.0005%, sodium selenite 0.001%, potassium iodate 0.0005%, sodium iodate 0.0006%, potassium iodate 0.0007%, potassium iodate 0.0008%, potassium iodide 0.0009%, potassium iodide 0.0017%, potassium iodide 0.0016 ... 0005%; the vitamins and the percentage by weight of the total weight of the formula milk powder for children aged 6-12 months are L-sodium ascorbate 0.002%, niacinamide 0.003%, D-calcium pantothenate 0.002%, thiamine hydrochloride 0.001%, retinyl acetate 0.002%, pyridoxine hydrochloride 0.002%, folic acid 0.003%, phytonadione 0.001%, D-biotin 0.001%, cholecalciferol 0.001%, cyanocobalamin 0.0005%, riboflavin 0.0005%, and choline bitartrate 0.001%.

[0021] The 12-36 month formula milk powder is added with minerals and vitamins, and the added amounts are 0.025% and 0.025% of the total weight of the 12-36 month formula milk powder respectively; the minerals and the percentage of the total weight of the 12-36 month formula milk powder are calcium chloride 0.006%, potassium chloride 0.005%, tricalcium phosphate 0.0025%, magnesium sulfate 0.003%, ferrous sulfate 0.002%, zinc lactate 0.0015%, copper sulfate 0.001%, manganese sulfate 0.001%, potassium iodate 0.0015%, selenious acid The vitamins and their percentage by weight for the total formula milk powder for children aged 12-36 months are 0.002% L-sodium ascorbate, 0.003% niacinamide, 0.003% D-calcium pantothenate, 0.002% thiamine hydrochloride, 0.002% retinyl acetate, 0.002% pyridoxine hydrochloride, 0.0045% folic acid, 0.002% phytonadione, 0.001% D-biotin, 0.001% cholecalciferol, 0.0005% cyanocobalamin, 0.001% riboflavin, and 0.001% choline bitartrate. Example 2

[0022] A baby formula milk powder, comprising a 0-6 month formula milk powder, a 6-12 month formula milk powder and a 12-36 month formula milk powder; the 0-6 month formula milk powder is composed of the following components in parts by weight: 550 parts of high-oil desalted whey powder, 40 parts of whole milk powder, 45 parts of whey protein powder, 15 parts of polyfructose, 5 parts of casein phosphopeptide, 1 part of 3'-sialyllactose, 3 parts of arachidonic acid oil, 3 parts of docosahexaenoic acid oil, 0.1 part of inositol, 0.3 part of nucleotides, L-carnitine tartrate 0.3 parts of salt, 0.1 parts of lutein, and 0.1 parts of taurine; the 6-12 month formula milk powder is composed of the following components in parts by weight: 550 parts of high oil desalted whey powder, 70 parts of whole milk powder, 70 parts of skim milk powder, 25 parts of whey protein powder, 2 parts of arachidonic acid oil, 3 parts of docosahexaenoic acid oil, 0.1 parts of inositol, 0.05 parts of nucleotides, 0.05 parts of L-carnitine tartrate, 0.05 parts of lutein, 0.05 parts of taurine, Bifidobacterium longum infantis subspecies CCFM1192 0.3 parts and Lactobacillus reuteri SS23-52 0.3 parts; the 12-36 month formula milk powder is composed of the following components in parts by weight: 450 parts of high-oil desalted whey powder, 60 parts of whole milk powder, 60 parts of skim milk powder, 35 parts of whey protein powder, 3 parts of arachidonic acid oil, 3 parts of docosahexaenoic acid oil, 0.2 parts of inositol, 0.1 parts of nucleotides, 3 parts of milk fat globule membrane, 0.1 parts of L-carnitine tartrate, 0.1 parts of lutein, 0.1 parts of taurine, 0.3 parts of animal Bifidobacterium lactis subspecies HN019, and 0.3 parts of animal Bifidobacterium lactis subspecies Bi-07.

[0023] The high-oil desalted whey powder is prepared from the following components in parts by weight: 320 parts of desalted whey, 110 parts of cream, 110 parts of vegetable blending oil, 12 parts of phospholipids, and 4 parts of sodium ascorbate; the vegetable blending oil is composed of the following components in parts by weight: 35 parts of soybean oil, 26 parts of sunflower oil, 23 parts of low-erucic acid rapeseed oil, 23 parts of coconut oil, 1.5 parts of mixed tocopherol concentrate, and 1.5 parts of ascorbyl palmitate.

[0024] Minerals and vitamins are also added to the 0-6 month formula milk powder, and the added amounts are 0.01% and 0.01% of the total weight of the 0-6 month formula milk powder respectively; the minerals and 0-6 month formula milk powder account for the following percentages of calcium chloride 0.002%, potassium chloride 0.002%, tricalcium phosphate 0.001%, magnesium sulfate 0.001%, ferrous sulfate 0.0005%, zinc lactate 0.001%, copper sulfate 0.0005%, manganese sulfate 0.001%, potassium iodate 0.0005%, sodium selenite 0.0005%; the vitamins and The percentage by weight of the total formula milk powder for children aged 0-6 months is 0.001% L-sodium ascorbate, 0.001% niacinamide, 0.001% D-calcium pantothenate, 0.0005% thiamine hydrochloride, 0.001% retinyl acetate, 0.0005% dl-α-tocopheryl acetate, 0.0005% pyridoxine hydrochloride, 0.001% folic acid, 0.0005% phytonadione, 0.001% D-biotin, 0.001% cholecalciferol, 0.0005% cyanocobalamin, 0.0005% riboflavin, and 0.0005% choline bitartrate.

[0025] Minerals and vitamins are further added to the 6-12 month formula milk powder, and the added amounts are 0.02% and 0.02% of the total weight of the 6-12 month formula milk powder, respectively; the minerals and the percentage of the total weight of the 6-12 month formula milk powder are 0.005% calcium chloride, 0.005% potassium chloride, 0.0015% tricalcium phosphate, 0.002% magnesium sulfate, 0.001% ferrous sulfate, 0.0015% zinc lactate, 0.001% copper sulfate, 0.001% manganese sulfate, 0.001% potassium iodate, and 0.001% sodium selenite; the vitamins are 0.02% calcium chloride, 0.005% potassium chloride, 0.0015% tricalcium phosphate, 0.002% magnesium sulfate, 0.001% ferrous sulfate, 0.0015% zinc lactate, 0.001% copper sulfate, 0.001% manganese sulfate, 0.001% potassium iodate, and 0.001% sodium selenite; The vitamins and their percentage by weight of the total formula milk powder for children aged 6-12 months are 0.003% L-sodium ascorbate, 0.002% niacinamide, 0.002% D-calcium pantothenate, 0.001% thiamine hydrochloride, 0.002% retinyl acetate, 0.002% dl-α-tocopheryl acetate, 0.002% pyridoxine hydrochloride, 0.001% folic acid, 0.001% phytonadione, 0.001% D-biotin, 0.001% cholecalciferol, 0.0005% cyanocobalamin, 0.0005% riboflavin, and 0.001% choline bitartrate.

[0026] The 12-36 month formula milk powder is further added with minerals and vitamins, and the added amounts are 0.027% and 0.028% of the total weight of the 12-36 month formula milk powder respectively; the minerals and the percentage of the total weight of the 12-36 month formula milk powder are 0.006% of calcium chloride, 0.005% of potassium chloride, 0.003% of tricalcium phosphate, 0.003% of magnesium sulfate, 0.002% of ferrous sulfate, 0.002% of zinc lactate, 0.001% of copper sulfate, 0.001% of manganese sulfate, 0.002% of potassium iodate, and 0.002% of sodium selenite; The vitamins and their percentage by weight of the total formula milk powder for children aged 12-36 months are 0.004% L-sodium ascorbate, 0.002% niacinamide, 0.003% D-calcium pantothenate, 0.002% thiamine hydrochloride, 0.002% retinyl acetate, 0.002% dl-α-tocopheryl acetate, 0.002% pyridoxine hydrochloride, 0.005% folic acid, 0.002% phytonadione, 0.001% D-biotin, 0.001% cholecalciferol, 0.0005% cyanocobalamin, 0.0005% riboflavin, and 0.001% choline bitartrate. Example 3

[0027] A baby formula milk powder, comprising a 0-6 month formula milk powder, a 6-12 month formula milk powder, and a 12-36 month formula milk powder; the 0-6 month formula milk powder is composed of the following components in parts by weight: 850 parts of high-oil desalted whey powder, 180 parts of whole milk powder, 85 parts of whey protein powder, 45 parts of polyfructose, 16 parts of casein phosphopeptide, 4 parts of 3'-sialyllactose, 8 parts of arachidonic acid oil, 8 parts of docosahexaenoic acid oil, 0.8 part of inositol, 0.8 part of nucleotides, 0.7 part of L-carnitine tartrate, 0.06 part of lutein, and 0.5 part of taurine; The 6-12 month formula milk powder is composed of the following components in parts by weight: 850 parts of high-oil desalted whey powder, 180 parts of whole milk powder, 180 parts of skim milk powder, 80 parts of whey protein powder, 6 parts of arachidonic acid oil, 6 parts of docosahexaenoic acid oil, 0.8 parts of inositol, 0.8 parts of nucleotides, 0.5 parts of L-carnitine tartrate, 0.8 parts of lutein, 0.8 parts of taurine, 1.5 parts of Bifidobacterium longum infantis subsp. CCFM1192, and Lactobacillus reuteri SS23-52 1.5 parts; the 12-36 month formula milk powder is composed of the following components in parts by weight: 750 parts of high-oil desalted whey powder, 160 parts of whole milk powder, 160 parts of skim milk powder, 80 parts of whey protein powder, 7 parts of arachidonic acid oil, 8 parts of docosahexaenoic acid oil, 0.6 parts of inositol, 0.6 parts of nucleotides, 7 parts of milk fat globule membrane, 0.7 parts of L-carnitine tartrate, 0.8 parts of lutein, 0.8 parts of taurine, 1 part of animal Bifidobacterium lactis subspecies HN019, and 1 part of animal Bifidobacterium lactis subspecies Bi-07.

[0028] The high-oil desalted whey powder is prepared from the following components in parts by weight: 550 parts of desalted whey, 145 parts of cream, 145 parts of vegetable blending oil, 18 parts of phospholipids, and 8 parts of sodium ascorbate; the vegetable blending oil is composed of the following components in parts by weight: 50 parts of soybean oil, 30 parts of sunflower oil, 30 parts of low-erucic acid rapeseed oil, 30 parts of coconut oil, 3 parts of mixed tocopherol concentrate, and 2 parts of ascorbyl palmitate.

[0029] Minerals and vitamins are also added to the 0-6 month formula milk powder, and the added amounts are 0.027% and 0.028% of the total weight of the 0-6 month formula milk powder respectively; the minerals and 0-6 month formula milk powder account for the following percentages of calcium chloride 0.005%, potassium chloride 0.004%, tricalcium phosphate 0.003%, magnesium sulfate 0.003%, ferrous sulfate 0.002%, zinc lactate 0.002%, copper sulfate 0.002%, manganese sulfate 0.002%, potassium iodate 0.002%, sodium selenite 0.002%; the vitamins are 0.027% and 0.028% of the total weight of the 0-6 month formula milk powder respectively; the minerals and vitamins ... are 0.027% and 0.028% of the total weight of the 0-6 month formula milk powder respectively; the minerals and vitamins are 0.027% and 0.028% of the total weight of the 0-6 month formula milk powder respectively; the minerals and vitamins are 0.027% and 0.028% of the total weight of the 0-6 month formula milk powder respectively; the minerals and vitamins are 0.027% and 0.028% of the total weight of the 0- The vitamins and their percentage by weight of the total formula milk powder for children aged 0-6 months are 0.005% L-sodium ascorbate, 0.003% niacinamide, 0.003% D-calcium pantothenate, 0.002% thiamine hydrochloride, 0.002% retinyl acetate, 0.002% dl-α-tocopheryl acetate, 0.002% pyridoxine hydrochloride, 0.001% folic acid, 0.001% phytonadione, 0.001% D-biotin, 0.002% cholecalciferol, 0.001% cyanocobalamin, 0.001% riboflavin, and 0.002% choline bitartrate.

[0030] The 6-12 month formula milk powder further contains minerals and vitamins, with the added amounts accounting for 0.031% and 0.034% of the total weight of the 6-12 month formula milk powder, respectively; the minerals and the percentages of the total weight of the 6-12 month formula milk powder are 0.008% calcium chloride, 0.005% potassium chloride, 0.005% tricalcium phosphate, 0.003% magnesium sulfate, 0.001% ferrous sulfate, 0.003% zinc lactate, 0.001% copper sulfate, 0.002% manganese sulfate, 0.001% potassium iodate, and 0.002% sodium selenite; the The vitamins and their percentage by weight of the total formula milk powder for children aged 6-12 months are 0.005% L-sodium ascorbate, 0.003% niacinamide, 0.003% D-calcium pantothenate, 0.002% thiamine hydrochloride, 0.003% retinyl acetate, 0.005% dl-α-tocopheryl acetate, 0.002% pyridoxine hydrochloride, 0.002% folic acid, 0.002% phytonadione, 0.002% D-biotin, 0.002% cholecalciferol, 0.001% cyanocobalamin, 0.001% riboflavin, and 0.001% choline bitartrate.

[0031] Minerals and vitamins are added to the formula milk powder for children aged 12-36 months, and the added amounts are 0.038% and 0.047% of the total weight of the formula milk powder for children aged 12-36 months, respectively; the minerals and the percentages of the total weight of the formula milk powder for children aged 12-36 months are 0.008% of calcium chloride, 0.006% of potassium chloride, 0.006% of tricalcium phosphate, 0.004% of magnesium sulfate, 0.002% of ferrous sulfate, 0.005% of zinc lactate, 0.001% of copper sulfate, 0.001% of manganese sulfate, 0.002% of potassium iodate, and 0.003% of sodium selenite; The vitamins and their percentage by weight of the total formula milk powder for children aged 12-36 months are 0.006% L-sodium ascorbate, 0.006% niacinamide, 0.004% D-calcium pantothenate, 0.004% thiamine hydrochloride, 0.003% retinyl acetate, 0.006% dl-α-tocopheryl acetate, 0.003% pyridoxine hydrochloride, 0.008% folic acid, 0.001% phytonadione, 0.002% D-biotin, 0.001% cholecalciferol, 0.001% cyanocobalamin, 0.001% riboflavin, and 0.001% choline bitartrate.

[0032] Comparative Example 1 A baby formula milk powder includes a 0-6 month formula milk powder, a 6-12 month formula milk powder and a 12-36 month formula milk powder; the 0-6 month formula milk powder contains 15 parts of casein phosphopeptide and does not contain 3'-sialyllactose, and is otherwise the same as in Example 1.

[0033] Comparative Example 2 An infant formula milk powder comprises a 0-6 month formula milk powder, a 6-12 month formula milk powder and a 12-36 month formula milk powder; the 0-6 month formula milk powder contains 15 parts of 3'-sialyllactose and does not contain casein phosphopeptide, and is otherwise the same as in Example 1.

[0034] Comparative Example 3 A baby formula milk powder comprises a 0-6 month formula milk powder, a 6-12 month formula milk powder and a 12-36 month formula milk powder; the 12-36 month formula milk powder contains 5.2 parts of milk fat globule membrane and does not contain L-carnitine tartrate, and other aspects are the same as those in Example 1.

[0035] Comparative Example 4 A baby formula milk powder comprises a 0-6 month formula milk powder, a 6-12 month formula milk powder and a 12-36 month formula milk powder; the 12-36 month formula milk powder contains 5.2 parts of L-carnitine tartrate and does not contain milk fat globule membrane, and is otherwise the same as in Example 1.

[0036] Experimental Example 1: Newly weaned Sprague Dawley rats were selected and fed a basal diet for one week to acclimate to the environment. They were then randomly divided into a control group, Example 1-3 groups, and Comparative Example 1-2 groups, with eight rats in each group. Formula milk powders for ages 0-6 months, prepared in Examples 1-3 and Comparative Example 1-2, were mixed with warm water to form milk at a ratio of 2g / 15mL. The rats were orally gavaged with milk at 9:00 AM daily at a dose of 0.15mL / 10g bw. Algal oil and algal oil microcapsule powder were emulsified with 0.5% sodium hydroxymethylcellulose solution to prepare an emulsion. The control group received the same volume of 0.5% sodium hydroxymethylcellulose solution with free access to food and water for 28 days. A five-day water maze test was performed five days before the end of the feeding period.

[0037] The water maze apparatus consisted of a circular water tank, an automatic video recorder, and a computer analysis and processing system. The water tank had a diameter of 1.5 meters and a height of 0.5 meters, and the water temperature was controlled at 23 ± 2°C. The circular water tank was divided into four quadrants, with a marked entry point in the middle of each quadrant for the rat to enter. The platform was located underwater in the second quadrant. The water maze experiment was conducted according to the method described by Guo Yanfen et al. (Guo Yanfen et al., 2011).

[0038] The experimental results were statistically analyzed using SPSS 24.0 software, and the measurement data were analyzed using ± (mean ± standard deviation) was expressed. The Kolmogorov-Smirnov test was used to test the normality of the data. For data that met the normal distribution, the t-test was used to compare the mean differences between the two groups. The difference was considered statistically significant when P < 0.05. The results are shown in Table 1: Table 1

[0039] Note: * represents P < 0.05 compared with the group in Example 1.

[0040] Experimental Example 2: Bifidobacterium longum subsp. infantis CCFM1192 and Lactobacillus reuteri SS23-52 were cultured in MRS medium supplemented with 1% cysteine and incubated anaerobicly at 37°C overnight. The cells were harvested and rinsed with saline solution. The probiotic concentration was adjusted and inoculated onto plates containing nematode growth medium (consistent with the nematode's age). Each plate contained 1 × 10 probiotics. 8 CFU. Divided into 4 groups: Bifidobacterium longum subspecies infantis CCFM1192 group, supplemented with 1×10 8 CFU bacteria; Lactobacillus reuteri SS23-52 group was supplemented with 1×10 8CFU bacteria; Bifidobacterium longum subsp. infantis CCFM1192 and Lactobacillus reuteri SS23-52 group, 5×10 7 CFU Bifidobacterium longum subsp. infantis CCFM1192 bacteria and 5×10 7 CFU of Lactobacillus reuteri SS23-52; the control was a nematode culture dish without added intervention.

[0041] After the nematodes became adults, they were transferred to a culture dish inoculated with Staphylococcus aureus ATCC25923, with a concentration of 2×10 8 CFU / mL was used to simulate infection with Staphylococcus aureus. Two controls were used: a culture dish without pathogenic bacteria and a culture dish infected with the pathogenic bacteria Staphylococcus aureus but without any intervention (a culture dish containing only Staphylococcus aureus). After the nematodes were cultured for several days, their survival rate was counted daily. If the nematodes did not respond to the platinum wire, they were considered dead. The survival rate of the nematodes on the second, fourth, and sixth days of culture is shown in Table 2: Table 2

[0042] Note: * represents P < 0.05 compared with the Bifidobacterium longum subsp. infantis CCFM1192 and Lactobacillus reuteri SS23-52 groups, ** represents P < 0.01.

[0043] Experimental Example 3: Eight-week-old C57BL / 6J mice weighing 19-21 g were fed a 60% high-fat diet (HFD, 60% fat, 20% carbohydrates, 20% protein) for one week (the control group was fed a standard diet, 6% fat, 55% carbohydrates, 21% protein, and 18% other). The C57BL / 6J mice were randomly divided into a control group, a model group, Example 1-3 groups, and Comparative Example 3-4 groups according to a random number table, with 10 mice in each group. The 12-36 month old formula milk powder prepared in Examples 1-3 and Comparative Examples 3-4 was mixed with warm water to form milk, with a milk powder to water ratio of 2 g / 15 mL. The mice were orally gavaged with milk at 9:00 a.m. every day, with a gavage volume of 0.1 mL / 10 g bw, once a day; the model group, Example 1-3 group, and Comparative Example 3-4 group continued to be fed a 60% high-fat diet, the model group was gavaged with an equal amount of water, and the control group was fed a normal diet and an equal amount of water; after 10 days, blood was collected from the mice for serum collection.

[0044] "Leaky gut" is a key link in metabolic inflammation caused by dysbiosis. LPS is the main lysate of intestinal Gram-negative bacteria and enters the blood through leaky gut. This experiment detected the levels of LPS, a marker of leaky gut, and inflammatory factor IL-1β in serum. The experimental results were statistically analyzed using SPSS 24.0 software. The quantitative data were analyzed using ± (mean ± standard deviation) was expressed. The Kolmogorov-Smirnov test was used to test the normality of the data. For data that met the normal distribution, the t-test was used to compare the mean differences between the two groups. The difference was considered statistically significant when P < 0.05. The results are shown in Table 3: Table 3

[0045] Note: * represents P < 0.05 compared with the group in Example 1, ** represents P < 0.01.

[0046] The above-described embodiments merely illustrate several implementations of the present invention, and while their descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, all of which fall within the scope of protection of the present invention. Therefore, the scope of protection of the patent for this invention shall be determined by the appended claims.

Claims

1. An infant formula milk powder, characterized in that, The invention comprises formula milk powder for children aged 0-6 months, formula milk powder for children aged 6-12 months and formula milk powder for children aged 12-36 months; the formula milk powder for children aged 0-6 months contains casein phosphopeptide and 3'-sialyllactose; the formula milk powder for children aged 6-12 months contains Bifidobacterium longum infantis subspecies CCFM1192 and Lactobacillus reuteri SS23-52; the formula milk powder for children aged 12-36 months contains L-carnitine tartrate and milk fat globule membrane.

2. The infant formula milk powder according to claim 1, wherein The 0-6 month formula milk powder is composed of the following components in parts by weight: 500-900 parts of high-oil desalted whey powder, 0-200 parts of whole milk powder, 1-100 parts of whey protein powder, 10-50 parts of polyfructose, 1-20 parts of casein phosphopeptide, 0.01-5 parts of 3'-sialyllactose, 1-10 parts of arachidonic acid oil, 1-10 parts of docosahexaenoic acid oil, 0.01-1 parts of inositol, 0.1-1 parts of nucleotides, 0.1-1 parts of L-carnitine tartrate, 0.01-1 parts of lutein, and 0.01-1 parts of taurine.

3. The infant formula milk powder according to claim 1, wherein The formula milk powder for babies aged 6 to 12 months is composed of the following components in parts by weight: 500-900 parts of high-oil desalted whey powder, 50-200 parts of whole milk powder, 50-200 parts of skim milk powder, 1-100 parts of whey protein powder, 1-10 parts of arachidonic acid oil, 1-10 parts of docosahexaenoic acid oil, 0.01-1 part of inositol, 0.01-1 part of nucleotides, 0.01-1 part of L-carnitine tartrate, 0.01-1 part of lutein, 0.01-1 part of taurine, 0.01-2 parts of Bifidobacterium longum infantis subspecies CCFM1192, and 0.01-1 part of Lactobacillus reuteri SS23-52.

4. The infant formula milk powder according to claim 1, wherein The formula milk powder for babies aged 12-36 months is composed of the following components in parts by weight: 400-800 parts of high-oil desalted whey powder, 50-200 parts of whole milk powder, 50-200 parts of skim milk powder, 1-100 parts of whey protein powder, 1-10 parts of arachidonic acid oil, 1-10 parts of docosahexaenoic acid oil, 0.01-1 parts of inositol, 0.01-1 parts of nucleotides, 1-10 parts of milk fat globule membrane, 0.01-1 parts of L-carnitine tartrate, 0.01-1 parts of lutein, 0.01-1 parts of taurine, 0.01-1 parts of animal Bifidobacterium lactis subspecies HN019, and 0.01-1 parts of animal Bifidobacterium lactis subspecies Bi-07.

5. The infant formula milk powder according to any one of claims 1 to 4, characterized in that The high-oil desalted whey powder is prepared from the following components in parts by weight: 300-600 parts of desalted whey, 100-150 parts of cream, 100-150 parts of vegetable blending oil, 10-20 parts of phospholipids, and 3-8 parts of sodium ascorbate.

6. The infant formula milk powder according to any one of claim 5, characterized in that The vegetable blended oil is composed of the following components in parts by weight: 30-50 parts of soybean oil, 25-30 parts of sunflower oil, 20-30 parts of low-erucic acid rapeseed oil, 20-30 parts of coconut oil, 1-3 parts of mixed tocopherol concentrate, and 1-3 parts of ascorbyl palmitate.

7. The infant formula milk powder according to any one of claims 1 to 4, characterized in that Minerals and vitamins are added to the 0-6 month formula milk powder, 6-12 month formula milk powder and 12-36 month formula milk powder, and the added amount accounts for 0.01-1% of the total weight of the formula milk powder.

8. The infant formula milk powder according to any one of claim 7, characterized in that The minerals are one or more of calcium chloride, potassium chloride, tricalcium phosphate, magnesium sulfate, ferrous sulfate, zinc lactate, copper sulfate, manganese sulfate, potassium iodate, and sodium selenite.

9. The infant formula milk powder according to any one of claim 7, characterized in that The vitamins are one or more of L-sodium ascorbate, dl-α-tocopheryl acetate, niacinamide, D-calcium pantothenate, thiamine hydrochloride, retinyl acetate, pyridoxine hydrochloride, folic acid, phytonadione, D-biotin, cholecalciferol, cyanocobalamin, riboflavin, and choline bitartrate.

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