Snake oil nanoemulsion and preparation method thereof

Abstract

The invention is suitable for the technical field of cosmetic preparation, and provides a snake oil nano-emulsion and a preparation method thereof, the snake oil nano-emulsion comprises the following components by mass: 40-60% of refined snake oil, 10-20% of an auxiliary oil phase, 5-10% of polysorbate-80, 3-8% of glyceryl stearate, 10-15% of a co-emulsifier and 20-30% of a water phase; the refined snake oil is Changbai mountain agkistrodon halys oil. The prepared snake oil nanoemulsion is good in stability, the use experience is effectively improved, and industrial application can be achieved in cooperation with a corresponding preparation method.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetic preparation, and in particular relates to a snake oil nanoemulsion and a preparation method thereof. Background Art

[0002] Snake oil (such as Changbai Mountain Pit Viper oil) is rich in unsaturated fatty acids (such as linoleic acid and linolenic acid) and has antioxidant, anti-inflammatory, and skin repair effects. However, most of them have the following problems:

[0003] Physical and chemical defects: high viscosity, strong fishy smell, easy to oxidize and deteriorate;

[0004] Poor stability: Traditional snake oil products are prone to stratification and deterioration, and the active ingredients are easily lost;

[0005] Insufficient transdermal absorption: The molecular weight is too large to effectively penetrate the skin.

[0006] In the existing technology, snake oil is often combined with ordinary emulsions, but this does not solve the above problems. Therefore, there is an urgent need for a new nanoemulsion carrier technology to improve the stability of snake oil, improve its physical and chemical properties, and enhance its transdermal absorption ability. Summary of the Invention

[0007] The purpose of the embodiments of the present invention is to provide a snake oil nanoemulsion and a preparation method thereof, aiming to solve the problems raised in the above background technology.

[0008] The embodiment of the present invention is achieved by a snake oil nanoemulsion comprising the following components and contents by mass percentage:

[0009] 40-60% refined snake oil, 10-20% auxiliary oil phase, 5-10% polysorbate 80, 3-8% glyceryl stearate, 10-15% co-emulsifier and 20-30% water phase;

[0010] The refined snake oil is Changbai Mountain Agkistrodon acutus oil.

[0011] In a further technical solution, the auxiliary oil phase can be one or more of olive oil and jojoba oil.

[0012] In a further technical solution, the co-emulsifier is propylene glycol or ethanol.

[0013] In a further technical solution, the aqueous phase is deionized water or a functional aqueous solution (such as a glycerol solution).

[0014] Another object of an embodiment of the present invention is to provide a method for preparing a snake oil nanoemulsion, based on the above-mentioned snake oil nanoemulsion, comprising the following steps:

[0015] Step 1: Snake oil refining;

[0016] The Changbai Mountain Agkistrodon halys snake oil was obtained, and impurities were removed by heating and refining (80°C, 2h) and organic extraction (washing with ether) to obtain refined snake oil.

[0017] Step 2: Nanoemulsion preparation;

[0018] The components were mixed according to the specified ratio, and then a high-pressure homogenizer (pressure 100-200 MPa, cycle 3-5 times) was used to prepare the nanoemulsion.

[0019] Further technical solution, said step 2 includes the following specific steps:

[0020] Step 2.1: Pre-emulsification;

[0021] Mix the refined snake oil and auxiliary oil phase with the emulsifier, heat to 60-70°C, and stir until uniform;

[0022] Step 2.2: High-pressure homogenization:

[0023] A high-pressure homogenizer (pressure 100-200 MPa, cycle 3-5 times) was used to form a nanoemulsion with a particle size of 50-200 nm.

[0024] A further technical solution is that in step 2, the specific proportions of the components are:

[0025] Refined snake oil (50%), olive oil (10%), jojoba oil (10%), polysorbate 80 (8%), glyceryl stearate (5%), propylene glycol (10%) and deionized water (7%).

[0026] The snake oil nanoemulsion and its preparation method provided in the embodiments of the present invention have the following beneficial effects:

[0027] (1) Improved stability: Nanoemulsion carriers significantly extend the shelf life of snake oil products and reduce stratification and oxidative deterioration;

[0028] (2) Improve user experience: reduce the viscosity and fishy smell of snake oil, making the product lighter and easier to absorb;

[0029] (3) Enhanced efficacy: Nanoemulsion promotes the transdermal absorption of snake oil active ingredients, improving the antioxidant and skin repair effects;

[0030] (4) Industrial application: Through pilot testing, ensure the repeatability of the process and the feasibility of large-scale production. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 The present invention provides a flowchart of a method for preparing a snake oil nanoemulsion. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0033] The specific implementation of the present invention is described in detail below with reference to specific embodiments.

[0034] One embodiment of the present invention provides a snake oil nanoemulsion comprising the following components and contents by mass percentage:

[0035] 40-60% refined snake oil, 10-20% auxiliary oil phase, 5-10% polysorbate 80, 3-8% glyceryl stearate, 10-15% co-emulsifier and 20-30% water phase;

[0036] The refined snake oil is Changbai Mountain Agkistrodon acutus oil.

[0037] As a preferred embodiment of the present invention, the auxiliary oil phase can be one or more of olive oil and jojoba oil.

[0038] As a preferred embodiment of the present invention, the co-emulsifier is propylene glycol or ethanol.

[0039] As a preferred embodiment of the present invention, the aqueous phase is deionized water or a functional aqueous solution (such as a glycerol solution).

[0040] Another embodiment of the present invention provides a method for preparing a snake oil nanoemulsion, based on the above-mentioned snake oil nanoemulsion, comprising the following steps:

[0041] Step 1: Snake oil refining;

[0042] The Changbai Mountain Agkistrodon halys snake oil was obtained, and impurities were removed by heating and refining (80°C, 2h) and organic extraction (washing with ether) to obtain refined snake oil.

[0043] Step 2: Nanoemulsion preparation;

[0044] The components were mixed according to the specified ratio, and then a high-pressure homogenizer (pressure 100-200 MPa, cycle 3-5 times) was used to prepare the nanoemulsion.

[0045] As a preferred embodiment of the present invention, step 2 includes the following specific steps:

[0046] Step 2.1: Pre-emulsification;

[0047] Mix the refined snake oil and auxiliary oil phase with the emulsifier, heat to 60-70°C, and stir until uniform;

[0048] Step 2.2: High-pressure homogenization:

[0049] A high-pressure homogenizer (pressure 100-200 MPa, cycle 3-5 times) was used to form a nanoemulsion with a particle size of 50-200 nm.

[0050] As a preferred embodiment of the present invention, in step 2, the specific proportions of the components are:

[0051] Refined snake oil (50%), olive oil (10%), jojoba oil (10%), polysorbate 80 (8%), glyceryl stearate (5%), propylene glycol (10%) and deionized water (7%).

[0052] As a preferred embodiment of the present invention, the stability of the prepared snake oil nanoemulsion is verified by a stability test.

[0053] Experimental methods:

[0054] Centrifugation experiment: centrifuge at 3000 rpm for 30 minutes and observe the stratification;

[0055] Freeze-thaw cycle: -20℃ to 40℃ for 5 cycles, 24 hours each time, and observe the changes in appearance;

[0056] Accelerated aging test: Store at 40°C for 30 days and detect changes in pH and particle size.

[0057] The experimental results are shown in Table 1 below;

[0058] Table 1

[0059]

[0060]

[0061] This indicates that snake oil nanoemulsions maintain physical stability under extreme conditions, while traditional emulsions are prone to failure due to stratification or increased particle size.

[0062] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A snake oil nanoemulsion, characterized in that The following components and contents are included by mass percentage: 40-60% refined snake oil, 10-20% auxiliary oil phase, 5-10% polysorbate 80, 3-8% glyceryl stearate, 10-15% co-emulsifier and 20-30% water phase; The refined snake oil is Changbai Mountain Agkistrodon acutus oil.

2. The snake oil nanoemulsion according to claim 1, characterized in that The auxiliary oil phase can be one or more of olive oil and jojoba oil.

3. The snake oil nanoemulsion according to claim 1, characterized in that The co-emulsifier is propylene glycol or ethanol.

4. The snake oil nanoemulsion according to claim 1, characterized in that The aqueous phase is deionized water or a functional aqueous solution.

5. A method for preparing a snake oil nanoemulsion, based on the snake oil nanoemulsion according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step 1: Snake oil refining; Taking the oil of the white-browed agkistrodon halys from Changbai Mountain, heating and refining it, and removing impurities through organic extraction, thus obtaining refined snake oil; Step 2: Nanoemulsion preparation; The components were mixed according to the specified ratio, and then a high-pressure homogenizer was used with a pressure of 100-200 MPa for 3-5 cycles to prepare the nanoemulsion.

6. The method for preparing the snake oil nanoemulsion according to claim 5, wherein: The step 2 includes the following specific steps: Step 2.1: Pre-emulsification; Mix the refined snake oil and auxiliary oil phase with the emulsifier, heat to 60-70°C, and stir until uniform; Step 2.2: High-pressure homogenization: A high-pressure homogenizer is used with a pressure of 100-200 MPa and circulated 3-5 times to form a nanoemulsion with a particle size of 50-200 nm.

7. The method for preparing the snake oil nanoemulsion according to claim 5, wherein: In step 2, the specific ratio of each component is: 50% refined snake oil, 10% olive oil, 10% jojoba oil, 8% polysorbate 80, 5% glyceryl stearate, 10% propylene glycol, and 7% deionized water.

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