Plaster composite adhesive based on natural viscosity of litsea glutinosa bark and preparation method of plaster composite adhesive

Abstract

The invention discloses a litsea glutinosa bark natural viscidity-based plaster composite adhesive and a preparation method thereof, and relates to the field of medicines, the litsea glutinosa bark natural viscidity-based plaster composite adhesive comprises the following raw materials by weight: 50-70 parts of litsea glutinosa bark extract glue liquid, 5-10 parts of bletilla striata powder, 3-8 parts of frankincense powder, 10-20 parts of honeysuckle extract liquid, 5-15 parts of ginger juice, 4-10 parts of beeswax, 3-8 parts of honey, 0.5-2 parts of borneol powder and 0.1-1 part of alum powder; according to the plaster composite adhesive based on the litsea glutinosa bark natural viscidity, the three effects of stopping bleeding, relieving pain and resisting bacteria are achieved through synergy of natural components, the plaster composite adhesive is suitable for trauma, inflammation and chronic skin problems, the adhesive performance is sufficient, and the plaster composite adhesive is not prone to falling off in the pasting process; no chemical synthesis additive is involved, the biocompatibility is high, and the allergy risk of a patient is reduced; the beeswax and the honey cooperate to prolong the storage life, so that the prepared adhesive can be directly taken for use, does not need to be blended on site, and is convenient for patients to use.

Description

Technical Field

[0001] The invention relates to medical technology, and in particular to a plaster composite adhesive based on natural stickiness of the bark of a Chinese yew tree and a preparation method thereof. Background Art

[0002] Litsea glutinosa (scientific name: Litsea glutinosa) is an evergreen tree or small tree of the genus Litsea in the Lauraceae family. Its roots, bark and leaves can be used as medicine, which has the effects of clearing dampness and heat, reducing swelling and toxins, stopping bleeding and relieving pain. The roots can treat diarrhea, bruises, mumps, and diabetes, and the bark and leaves can treat sores, carbuncles, early-stage mastitis, bruises, and traumatic bleeding.

[0003] The existing technology for preparing the powder of the Chinese tallow tree is to grind it into powder, add water to make a binder, and then add other medicinal powders to make a paste for external application. However, when patients have trauma, it is usually necessary to stop bleeding, reduce swelling and pain, and reduce inflammation and antibacterial effects at the same time. Therefore, multiple medicinal powders need to be added. However, some powdered drugs are difficult to completely dissolve, resulting in poor viscosity and difficulty in absorbing the undissolved medicinal powder.

[0004] Natural adhesives such as peach gum and gum arabic are not sticky enough or have a single function, and cannot meet the needs of multi-functionality.

[0005] Existing traditional Chinese medicine plasters mostly use animal glue such as fish bladder glue as the matrix, which has problems such as scarce raw materials and complex processes; Summary of the Invention

[0006] The purpose of the present invention is to provide a plaster composite adhesive based on the natural sticky substance of the bark of the mulberry tree and a preparation method thereof, so as to solve the above-mentioned shortcomings in the prior art.

[0007] In order to achieve the above object, the present invention provides the following technical solution: a plaster composite adhesive based on the natural sticky substance of the bark of the euphorbia pulex, the raw materials of which include, by weight:

[0008] 50-70 parts of gum extracted from the bark of the Chinese yew tree, 5-10 parts of bletilla striata powder, 3-8 parts of frankincense powder, 10-20 parts of honeysuckle extract, 5-15 parts of ginger juice, 4-10 parts of beeswax, 3-8 parts of honey, 0.5-2 parts of borneol powder and 0.1-1 part of alum powder.

[0009] Furthermore, the preparation method of the glue extracted from the bark of the mulberry tree is as follows: crush the bark of the mulberry tree to 60-100 meshes, add water and mix according to the weight ratio of the bark powder to water of 1:5-1:10, extract at a low boiling temperature of 90-95°C for 40-60 minutes, and filter and concentrate the extracted mixture to a solid content of 15%-25%.

[0010] Furthermore, the weight ratio of the beeswax to honey is 1:0.8 to 1:1.5, and the melting temperature of the beeswax is 70 to 75°C.

[0011] Furthermore, it also contains at least one of the following components:

[0012] 0.1-0.5 parts of tea tree essential oil;

[0013] 2-5 parts of zinc oxide;

[0014] 3 to 6 portions of Panax notoginseng powder.

[0015] Furthermore, the borneol powder has a particle size of ≤50 μm and is added to the mixing system at 45-50° C.

[0016] A method for preparing a plaster composite adhesive based on the natural stickiness of the bark of a sedge tree, which is applicable to the plaster composite adhesive based on the natural stickiness of the bark of a sedge tree. The method for preparing a plaster composite adhesive based on the natural stickiness of the bark of a sedge tree is used to prepare a plaster composite adhesive based on the natural stickiness of the bark of a sedge tree, comprising the following steps:

[0017] S1, after washing and drying the dried chancao bark, using a grinder to grind it to 60-80 mesh, obtaining a uniform chancao bark powder, according to the weight ratio of chancao bark powder to water of 1:5-1:10, adding it to an extraction container, and heating it to 90-95 ° C., maintaining it for 40-60 minutes, stirring it every ten minutes during the period to promote the release of chancao bark colloid, using a 200 mesh filter with a double layer of gauze to filter, discarding the residue, transferring the filtrate to a concentration container, and concentrating it under reduced pressure at 80-85 ° C. to a solid content of 15% to 25%, to obtain a chancao bark extract;

[0018] S2, transferring the glue solution extracted from the bark of the sedge tree obtained in S1 to a thermostatic stirring kettle, adjusting the temperature of the thermostatic stirring kettle to 60-65° C., adding the white striata powder and frankincense powder to the glue solution extracted from the bark of the sedge tree, opening the thermostatic stirring kettle and stirring continuously at a speed of 200-300 rpm for 15-20 minutes, until the white striata powder and frankincense powder are completely dissolved in the glue solution extracted from the bark of the sedge tree and no visible particles are left, to obtain a preliminary mixed glue solution;

[0019] S3. Slowly add ginger juice and honeysuckle extract to the preliminary mixed glue solution obtained in S2, control the flow rate to 5-10 ml / min, and maintain the stirring speed at 300-400 rpm. Add alum powder, and use a pH meter to monitor the pH of the system in real time after adding alum powder. Adjust the pH to 5.5-6.5 by dropwise adding 10% w / w citric acid solution to obtain an acidic glue solution;

[0020] S4. Chop the beeswax into block particles with a particle size of ≤5 mm, mix the beeswax particles with honey in a weight ratio of 1:1 to 1:2, heat at 70 to 75° C. in a water bath until the beeswax is completely melted to obtain a liquid mixture, slowly pour the liquid mixture into the acidic glue in S3, and homogenize using a high-speed homogenizer at 3000 to 4000 rpm for 3 to 5 minutes to obtain a stable emulsion;

[0021] S5. After cooling the stable emulsion in S4 to 45-50° C. at a cooling rate of ≤2° C. / min, borneol powder is added to a high-speed homogenizer, and any one or more of essential oil, zinc oxide, and Panax notoginseng powder are selectively added as needed. The mixture is stirred at 400-500 rpm for 10-15 minutes until the powder is completely dispersed, thereby obtaining a plaster composite adhesive with natural sticky properties of the bark of the yew tree;

[0022] S6. Fill the natural sticky plaster composite adhesive obtained from the bark of the mulberry tree obtained in S5 into a container at 45-50° C., then affix a label to the container. After filling, cool and solidify in a dark environment below 25° C. for 12-24 hours. After solidification, put it into storage.

[0023] Furthermore, in S3, when the pH value of the system is less than 5.5, sodium bicarbonate solution is used to adjust the pH value to 5.5-6.5.

[0024] Application of a plaster composite adhesive based on the natural stickiness of the bark of the sedge tree in the preparation of medical plasters, band-aids or rheumatism analgesic patches: the plaster composite adhesive based on the natural stickiness of the bark of the sedge tree is directly used as a plaster matrix or compounded with active pharmaceutical ingredients.

[0025] Compared with the existing technology, the plaster composite adhesive based on the natural sticky substance of the bark of the mulberry tree and its preparation method provided by the present invention achieves the three-in-one effects of hemostasis, analgesia and antibacterial through the synergistic effect of natural ingredients. It is suitable for trauma, inflammation and chronic skin problems, and has sufficient adhesive properties, making it difficult to fall off when pasted.

[0026] No chemical synthetic additives are involved, with high biocompatibility, reducing the risk of allergies in patients;

[0027] Beeswax and honey work together to extend the shelf life, so that the prepared adhesive can be directly taken and used without on-site mixing, which is convenient for patients to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments described in the present invention. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0029] Figure 1 A flow chart for preparing a plaster composite adhesive based on the natural stickiness of the bark of the mulberry tree provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0030] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0031] Example 1:

[0032] A plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex and a preparation method thereof, wherein the raw materials thereof include, by weight:

[0033] 50-70 parts of gum extracted from the bark of the Chinese yew tree, 5-10 parts of bletilla striata powder, 3-8 parts of frankincense powder, 10-20 parts of honeysuckle extract, 5-15 parts of ginger juice, 4-10 parts of beeswax, 3-8 parts of honey, 0.5-2 parts of borneol powder and 0.1-1 part of alum powder.

[0034] The preparation method of the glue solution extracted from the bark of the euphorbia pulverata is as follows: crushing the bark of the euphorbia pulverata to 60-100 meshes, adding water and mixing according to the weight ratio of the bark powder to water of 1:5-1:10, extracting at a low boiling temperature of 90-95°C for 40-60 minutes, filtering and concentrating the extracted mixture to a solid content of 15%-25%.

[0035] The weight ratio of the beeswax to the honey is 1:0.8 to 1:1.5, and the melting temperature of the beeswax is 70 to 75°C.

[0036] Also contains at least one of the following components:

[0037] 0.1-0.5 parts of tea tree essential oil;

[0038] 2-5 parts of zinc oxide;

[0039] 3 to 6 portions of Panax notoginseng powder.

[0040] The particle size of the borneol powder is ≤50 μm and is added into the mixing system at 45-50° C.

[0041] Example 2:

[0042] See also Figure 1 This embodiment provides a technical solution based on the first embodiment: a method for preparing a plaster composite adhesive based on the natural sticky substance of the bark of the euphorbia pulex, comprising the following steps:

[0043] S1, after washing and drying the dried chancao bark, using a grinder to grind it to 60-80 mesh, obtaining a uniform chancao bark powder, according to the weight ratio of chancao bark powder to water of 1:5-1:10, adding it to an extraction container, and heating it to 90-95 ° C., maintaining it for 40-60 minutes, stirring it every ten minutes during the period to promote the release of chancao bark colloid, using a 200 mesh filter with a double layer of gauze to filter, discarding the residue, transferring the filtrate to a concentration container, and concentrating it under reduced pressure at 80-85 ° C. to a solid content of 15% to 25%, to obtain a chancao bark extract;

[0044] S2, transferring the glue solution extracted from the bark of the sedge tree obtained in S1 to a thermostatic stirring kettle, adjusting the temperature of the thermostatic stirring kettle to 60-65° C., adding the white striata powder and frankincense powder to the glue solution extracted from the bark of the sedge tree, opening the thermostatic stirring kettle and stirring continuously at a speed of 200-300 rpm for 15-20 minutes, until the white striata powder and frankincense powder are completely dissolved in the glue solution extracted from the bark of the sedge tree and no visible particles are left, to obtain a preliminary mixed glue solution;

[0045] S3. Slowly add ginger juice and honeysuckle extract to the preliminary mixed glue solution obtained in S2, control the flow rate to 5-10 ml / min, and maintain the stirring speed at 300-400 rpm. Add alum powder, and use a pH meter to monitor the pH of the system in real time after adding alum powder. Adjust the pH to 5.5-6.5 by dropwise adding 10% w / w citric acid solution to obtain an acidic glue solution;

[0046] S4. Chop the beeswax into block particles with a particle size of ≤5 mm, mix the beeswax particles with honey in a weight ratio of 1:1 to 1:2, heat at 70 to 75° C. in a water bath until the beeswax is completely melted to obtain a liquid mixture, slowly pour the liquid mixture into the acidic glue in S3, and homogenize using a high-speed homogenizer at 3000 to 4000 rpm for 3 to 5 minutes to obtain a stable emulsion;

[0047] S5. After cooling the stable emulsion in S4 to 45-50° C. at a cooling rate of ≤2° C. / min, borneol powder is added to a high-speed homogenizer, and any one or more of essential oil, zinc oxide, and Panax notoginseng powder are selectively added as needed. The mixture is stirred at 400-500 rpm for 10-15 minutes until the powder is completely dispersed, thereby obtaining a plaster composite adhesive with natural sticky properties of the bark of the yew tree;

[0048] S6. Fill the natural sticky plaster composite adhesive obtained from the bark of the mulberry tree obtained in S5 into a container at 45-50° C., then affix a label to the container. After filling, cool and solidify in a dark environment below 25° C. for 12-24 hours. After solidification, put it into storage.

[0049] In the step S3, when the pH value of the system is less than 5.5, a sodium bicarbonate solution is used to adjust the pH value to 5.5-6.5.

[0050] Example 3: Application of a plaster composite adhesive based on the natural stickiness of the bark of the mulberry tree in the preparation of medical patches, band-aids or rheumatism pain relief patches, characterized in that the plaster composite adhesive based on the natural stickiness of the bark of the mulberry tree is directly used as a plaster matrix or compounded with active pharmaceutical ingredients.

[0051] Example 4:

[0052] The formula is selected by weight:

[0053] 70 parts of glue extracted from the bark of Chancao tree, 10 parts of Bletilla striata powder, 5 parts of frankincense powder, 15 parts of honeysuckle extract, 10 parts of ginger juice, 8 parts of beeswax, 5 parts of honey, 1 part of borneol powder and 0.5 parts of alum powder;

[0054] Process parameters:

[0055] The bark of the Changao tree is crushed to 80 mesh, mixed with water at a powder-water ratio of 1:8, extracted at 95°C for 50 minutes, and concentrated to a solid content of 20% to obtain a Changao tree bark extract. Bletilla striata powder and frankincense powder are added at 63°C and stirred at 260 rpm for 18 minutes until the Bletilla striata powder and frankincense powder are completely dissolved. Ginger juice and honeysuckle extract are then added at 8 ml / min and stirred at 150 rpm. Alum powder is added and the pH is adjusted to 6.0 with a 10% w / w citric acid solution. The molten liquid mixture of honey and beeswax is homogenized at 3000 rpm for 4 minutes, and borneol powder is added and stirred until completely dissolved. The mixture is completely solidified at 20°C for 15 hours.

[0056] Performance testing:

[0057] Adhesion: Initial adhesion 1.8N / cm in line with GB / T4851-2014;

[0058] Antibacterial rate: The antibacterial rate against Staphylococcus aureus is 92%, which complies with GB / T20944.3-2008.

[0059] Embodiment 5:

[0060] The formula is selected by weight:

[0061] 60 parts of safflower bark extract, 8 parts of white hyacinth powder, 6 parts of frankincense powder, 20 parts of honeysuckle extract, 8 parts of ginger juice, 10 parts of beeswax, 5 parts of honey, 1.5 parts of borneol powder, 0.3 parts of alum powder, 5 parts of zinc oxide

[0062] Process adjustment

[0063] pH adjustment: first adjust the pH to 5.2 with 10% w / w citric acid solution, then adjust to 6.0 with sodium bicarbonate solution;

[0064] Homogenization: 3500 rpm in two stages (2 minutes + 3 minutes).

[0065] Performance Testing

[0066] Water resistance: Adhesion retention rate after immersion in water for 24 hours is 85%;

[0067] Astringency: The time for wound exudate to decrease is shortened by 30%.

[0068] Example 6:

[0069] The formula is selected by weight:

[0070] 50 parts of glue extracted from the bark of Chancao tree, 5 parts of bletilla striata powder, 8 parts of frankincense powder, 10 parts of honeysuckle extract, 15 parts of ginger juice, 4 parts of beeswax, 8 parts of honey, 2 parts of borneol powder, 1 part of alum powder, and 6 parts of Panax notoginseng powder.

[0071] The preparation process is the same as that of Example 5, except that the notoginseng powder and borneol powder are added simultaneously;

[0072] Performance Testing

[0073] Analgesic effect: The rat writhing test showed a pain inhibition rate of 78%;

[0074] Blood circulation function: Laser Doppler detection showed that the local microcirculation blood flow of rats increased by 40%.

[0075] Embodiment seven:

[0076] The formula is selected by weight:

[0077] 65 parts of safflower bark extract, 7 parts of bletilla striata powder, 4 parts of frankincense powder, 18 parts of honeysuckle extract, 12 parts of ginger juice, 6 parts of beeswax, 6 parts of honey, 0.8 parts of borneol powder, 0.2 parts of alum powder and 0.3 parts of tea tree essential oil;

[0078] Process adjustment

[0079] The preparation process is the same as that of Example 5, except that tea tree essential oil and borneol powder are added simultaneously, mixed, and then ultrasonically dispersed for 10 minutes;

[0080] Performance Testing

[0081] Broad-spectrum antibacterial: The inhibition rate against Escherichia coli (ATCC25922) is 95%, and the inhibition rate against Candida albicans is 88%.

[0082] Volatile retention: GC-MS detection of tea tree essential oil retention rate ≥ 90%.

[0083] Embodiment 8:

[0084] The formula is selected by weight:

[0085] 55 parts of glutinous liquid extracted from the bark of the Chinese yew tree, 6 parts of white hyacinth powder, 7 parts of frankincense powder, 12 parts of honeysuckle extract, 7 parts of ginger juice, 7 parts of beeswax, 4 parts of honey, 1.2 parts of borneol powder, 0.4 parts of alum powder, 3 parts of zinc oxide, 4 parts of Panax notoginseng powder, and 0.2 parts of tea tree essential oil;

[0086] Process adjustment

[0087] Zinc oxide and Panax notoginseng powder are premixed and then added to the glue solution;

[0088] Tea tree essential oil and borneol powder are ground together and then added;

[0089] Adjust pH to 5.8;

[0090] Performance test is shown in Table 1:

[0091]

[0092]

[0093] Table 1

[0094] The above description is merely illustrative of certain exemplary embodiments of the present invention. It goes without saying that those skilled in the art will be able to modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and description are illustrative in nature and should not be construed as limiting the scope of protection of the claims.

Claims

1. A plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex, characterized in that: The raw materials include by weight: 50-70 parts of gum extracted from the bark of the Chinese yew tree, 5-10 parts of bletilla striata powder, 3-8 parts of frankincense powder, 10-20 parts of honeysuckle extract, 5-15 parts of ginger juice, 4-10 parts of beeswax, 3-8 parts of honey, 0.5-2 parts of borneol powder and 0.1-1 part of alum powder.

2. The plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex according to claim 1, characterized in that: The preparation method of the glue solution extracted from the bark of the euphorbia pulverata is as follows: crushing the bark of the euphorbia pulverata to 60-100 meshes, adding water and mixing according to the weight ratio of the bark powder to water of 1:5-1:10, extracting at a low boiling temperature of 90-95°C for 40-60 minutes, filtering and concentrating the extracted mixture to a solid content of 15%-25%.

3. The plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex according to claim 1, characterized in that: The weight ratio of the beeswax to the honey is 1:0.8 to 1:1.5, and the melting temperature of the beeswax is 70 to 75°C.

4. The plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex according to claim 1, characterized in that: Also contains at least one of the following components: 0.1-0.5 parts of tea tree essential oil; 2-5 parts of zinc oxide; 3 to 6 portions of Panax notoginseng powder.

5. The plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex according to claim 1, characterized in that: The particle size of the borneol powder is ≤50 μm and is added into the mixing system at 45-50° C.

6. A method for preparing a plaster composite adhesive based on the natural stickiness of the bark of the eucalyptus globulus, which is applicable to the plaster composite adhesive based on the natural stickiness of the bark of the eucalyptus globulus according to any one of claims 1 to 5. The method for preparing a plaster composite adhesive based on the natural stickiness of the bark of the eucalyptus globulus is used to prepare a plaster composite adhesive based on the natural stickiness of the bark of the eucalyptus globulus, characterized in that: The steps include: S1, after washing and drying the dried chancao bark, using a grinder to grind it to 60-80 mesh, obtaining a uniform chancao bark powder, according to the weight ratio of chancao bark powder to water of 1:5-1:10, adding it to an extraction container, and heating it to 90-95 ° C., maintaining it for 40-60 minutes, stirring it every ten minutes during the period to promote the release of chancao bark colloid, using a 200 mesh filter with a double layer of gauze to filter, discarding the residue, transferring the filtrate to a concentration container, and concentrating it under reduced pressure at 80-85 ° C. to a solid content of 15% to 25%, to obtain a chancao bark extract; S2, transferring the glue solution extracted from the bark of the sedge tree obtained in S1 to a thermostatic stirring kettle, adjusting the temperature of the thermostatic stirring kettle to 60-65° C., adding the white striata powder and frankincense powder to the glue solution extracted from the bark of the sedge tree, opening the thermostatic stirring kettle and stirring continuously at a speed of 200-300 rpm for 15-20 minutes, until the white striata powder and frankincense powder are completely dissolved in the glue solution extracted from the bark of the sedge tree and no visible particles are left, to obtain a preliminary mixed glue solution; S3. Slowly add ginger juice and honeysuckle extract to the preliminary mixed glue solution obtained in S2, control the flow rate to 5-10 ml / min, and maintain the stirring speed at 300-400 rpm. Add alum powder, and use a pH meter to monitor the pH of the system in real time after adding alum powder. Adjust the pH to 5.5-6.5 by dropwise adding 10% w / w citric acid solution to obtain an acidic glue solution; S4. Chop the beeswax into block particles with a particle size of ≤5 mm, mix the beeswax particles with honey in a weight ratio of 1:1 to 1:2, heat at 70 to 75° C. in a water bath until the beeswax is completely melted to obtain a liquid mixture, slowly pour the liquid mixture into the acidic glue in S3, and homogenize using a high-speed homogenizer at 3000 to 4000 rpm for 3 to 5 minutes to obtain a stable emulsion; S5. After cooling the stable emulsion in S4 to 45-50° C. at a cooling rate of ≤2° C. / min, borneol powder is added to a high-speed homogenizer, and any one or more of essential oil, zinc oxide, and Panax notoginseng powder are selectively added as needed. The mixture is stirred at 400-500 rpm for 10-15 minutes until the powder is completely dispersed, thereby obtaining a plaster composite adhesive with natural sticky properties of the bark of the yew tree; S6. Fill the natural sticky plaster composite adhesive obtained from the bark of the mulberry tree obtained in S5 into a container at 45-50° C., then affix a label to the container. After filling, cool and solidify in a dark environment below 25° C. for 12-24 hours. After solidification, put it into storage.

7. The method for preparing a plaster composite adhesive based on the natural stickiness of the bark of the Chinese yam tree according to claim 6, characterized in that: In the step S3, when the pH value of the system is less than 5.5, a sodium bicarbonate solution is used to adjust the pH value to 5.5-6.

5.

8. Use of the plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex according to any one of claims 1 to 5 in the preparation of medical plasters, band-aids or rheumatism analgesic patches, characterized in that: The plaster composite adhesive based on the natural stickiness of the bark of the euphorbia pulex is directly used as a plaster matrix or is compounded with active pharmaceutical ingredients for use.

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