Diglyceride oil powder for body weight management and preparation method thereof

Abstract

The invention relates to the technical field of weight management, in particular to diglyceride oil powder for weight management and a preparation method of the diglyceride oil powder. The invention discloses diglyceride oil powder for weight management. The diglyceride oil powder comprises the following substances in parts by weight: 18-30 parts of flaxseed diglyceride; 10 to 20 parts of a konjak extract; 3 to 8 parts of L-carnitine; 3-8 parts of a white kidney bean extract; 2-5 parts of a green coffee extract; the flaxseed diglyceride is flaxseed diglyceride in which the sn-1, 3 structure proportion is greater than or equal to 85%. The multi-target body weight regulation network is constructed by taking flaxseed diglyceride as a core and combining the konjak extract, the L-carnitine, the white kidney bean extract and the green coffee extract. And a synergistic effect of'fat-carbon water double blocking + energy consumption 'is formed. The composition breaks through the action limitation of a single component by regulating and controlling full links of intake, absorption and metabolism.

Description

Technical Field

[0001] The present invention relates to the technical field of weight management, and in particular to a diglyceride oil powder for weight management and a preparation method thereof. Background Art

[0002] Traditional weight management methods mainly rely on diet control, exercise intervention and drug therapy, but they have significant limitations: low compliance with diet and exercise programs, and long-term effects are difficult to maintain; although drug intervention can inhibit fat absorption, it is accompanied by gastrointestinal side effects, and it is easy to rebound after stopping the drug; although surgery can quickly reduce weight, it has a high risk of trauma and is expensive. In recent years, functional foods have gradually become a research hotspot due to their natural and safe characteristics, but their development still faces a core problem - how to achieve sustainable fat loss through precise metabolic regulation rather than simply relying on calorie restriction. Existing meal replacement products mostly use high dietary fiber or protein compounds. Although they can increase satiety in the short term, they lack targeted regulation of key pathways of fat metabolism, resulting in a limited reduction in body fat percentage and an inability to improve metabolic indicators such as insulin sensitivity.

[0003] In response to the above-mentioned related technologies, the inventors found that the current research on functional ingredients for weight management mainly focuses on three major directions: fat metabolism regulation, carbohydrate absorption inhibition, and energy consumption promotion. Although these ingredients have shown potential in in vitro experiments, their actual application effects are greatly reduced due to technical limitations. Existing compounding schemes mostly use simple physical mixing, lacking synergistic enhancement design between ingredients. Most products only target a single metabolic pathway and lack systematic intervention in the entire link of "intake-absorption-storage-consumption", resulting in a slow decline in body fat percentage. Secondly, the stability and delivery efficiency of weight management functional ingredients are insufficient. High-temperature processing causes the activity loss rate of heat-sensitive ingredients to exceed 40%; fat-soluble ingredients have poor compatibility with aqueous media and are easily stratified after being brewed with cold water, with an actual absorption rate of less than 50%. Summary of the Invention

[0004] In order to improve the defects of the existing weight management functional ingredients, such as the single metabolic regulation and insufficient ingredient stability and delivery efficiency, the present application provides a diglyceride oil powder for weight management and a preparation method thereof.

[0005] In a first aspect, the present application provides a diglyceride oil powder for weight management, which adopts the following technical solution:

[0006] A diglyceride oil powder for weight management comprises the following substances in parts by weight: 18-30 parts of flaxseed diglyceride; 10-20 parts of konjac extract; 3-8 parts of L-carnitine; 3-8 parts of white kidney bean extract; and 2-5 parts of green coffee extract. The flaxseed diglyceride has a sn-1,3 structure accounting for ≥85%.

[0007] Through the above technical solution, this application takes flaxseed diglyceride as the core, combined with konjac extract, L-carnitine, white kidney bean extract and green coffee extract, to construct a multi-target weight regulation network. Flaxseed diglyceride activates the PPARα receptor and preferentially enters the mitochondrial β-oxidation pathway rather than the fat storage pathway; konjac extract enhances satiety by prolonging gastric emptying time; L-carnitine and flaxseed diglyceride synergistically promote the transport of fatty acids across the mitochondrial membrane, solving the rate-limiting bottleneck of carnitine palmitoyltransferase; white kidney bean extract inhibits the decomposition of carbohydrates into glucose, and green coffee extract activates the AMPK pathway to promote fat decomposition, forming a "fat-carbohydrate double blocking + energy consumption" synergistic effect. This combination breaks through the limitations of a single ingredient by regulating the entire chain of intake, absorption, and metabolism.

[0008] Furthermore, the flaxseed diglyceride with a sn-1,3 structure accounting for ≥85% is prepared using the following technical solution:

[0009] Take linseed diglyceride and distill it at 150-160℃ and 3-5MPa for 25-30min;

[0010] The distillate is taken and placed in a secondary distillation process at 200-220° C. and a pressure of 1-3 MPa for 25-30 minutes to prepare flaxseed diglyceride with a sn-1,3 structure accounting for ≥85%.

[0011] Through the above technical solution, this application uses a two-stage molecular distillation process to precisely enrich the sn-1,3 structure. The first stage removes free fatty acids and low-molecular-weight impurities, reducing the acid value. The second stage selectively evaporates the remaining sn-1,2 isomer based on the boiling point difference between the sn-1,3 structure and the sn-1,2 structure. This process overcomes the temperature limitations of traditional distillation by suppressing high-temperature oxidation side reactions through high pressure, while simultaneously utilizing the high vacuum of molecular distillation to reduce thermal decomposition.

[0012] Furthermore, the diglyceride oil powder for weight management further comprises 1-5 parts by weight of α-linolenic acid microcapsule powder.

[0013] Through the above technical solution, this application further adds α-linolenic acid as an essential fatty acid to form a complex with flaxseed diglycerides with a sn-1,3 structure, enhancing efficacy through a dual mechanism: first, α-linolenic acid is converted into EPA / DHA by the liver, inhibiting the activity of lipase and reducing new fat production; second, the ALA-DAG structure enhances the intestinal lymphatic absorption pathway, bypassing the portal vein first-pass effect and improving bioavailability. At the same time, the microencapsulation uses sodium alginate as a wall material, which releases through pH response, preventing gastric acid from destroying the cis double bond structure of α-linolenic acid.

[0014] Furthermore, the α-linolenic acid microcapsule powder is prepared using the following technical solution:

[0015] After linseed oil and sodium alginate are sheared and emulsified, the emulsion is collected and placed in a spray drying device for spray drying to prepare the α-linolenic acid microcapsule powder.

[0016] Through the above-mentioned technical solution, this application achieves efficient encapsulation of α-linolenic acid through a spray-drying process using sodium alginate as the wall material. During the shear emulsification stage, a stable emulsion is formed, with sodium alginate bonding to the hydrophobic end of α-linolenic acid via its carboxyl groups, forming a bilayer structure. The spray-drying stage utilizes the film-forming properties of sodium alginate to rapidly dehydrate and form porous microcapsules. Compared to traditional gelatin encapsulation, sodium alginate microcapsules offer superior targeting.

[0017] Furthermore, the diglyceride oil powder for weight management further comprises 1-8 parts by weight of brown algae oligosaccharide.

[0018] Through the above technical solution, this application selects brown algae oligosaccharides as prebiotics, promoting the production of short-chain fatty acids by selectively proliferating beneficial bacteria such as bifidobacteria and lactic acid bacteria. Short-chain fatty acids activate intestinal L cells to secrete GLP-1, suppressing appetite and enhancing insulin sensitivity. At the same time, brown algae oligosaccharides and konjac glucomannan form a composite dietary fiber network, extending the duration of the gel barrier in the stomach and reducing calorie intake. Its low molecular weight ensures targeted fermentation in the colon, avoiding premature degradation in the stomach.

[0019] Furthermore, the konjac extract is phosphorylated modified glucomannan

[0020] Through the above technical solution, this application selected phosphorylated glucomannan. After modification, its solubility is further improved, and the hydrogen bonding between the acid groups and water molecules further increases viscosity, expanding the gel volume in the stomach and prolonging the duration of satiety. Furthermore, phosphorylation modification imparts resistance to enzymatic degradation, reducing its degradation rate in the environment of pepsin.

[0021] In a second aspect, the present application provides a method for preparing diglyceride oil powder for weight management, using the following technical solution:

[0022] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0023] L-carnitine, green coffee extract and α-linolenic acid microcapsule powder were mixed, soybean lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0024] Konjac extract and sodium alginate were used as double-layer wall materials, and white kidney bean extract, brown algae oligosaccharide, linseed diglyceride and nanoemulsion were embedded respectively through gradient embedding process;

[0025] After supercritical CO2-assisted spray drying, nano-silicon dioxide and microcrystalline cellulose are added, and the mixture is fluidized bed coated and then packaged to prepare the diglyceride oil powder for weight management.

[0026] This application uses high-pressure homogenization to nano-size L-carnitine, green coffee extract, α-linolenic acid and linseed diglyceride to solve the compatibility problem of fat-soluble and water-soluble components, and at the same time supercritical CO2-assisted spray drying reduces the loss of heat-sensitive components.

[0027] Furthermore, the gradient embedding process adopts the following technical solutions:

[0028] Phosphorylated modified glucomannan was selected as the primary embedding wall material, white kidney bean extract, linseed diglyceride and nanoemulsion were subjected to a primary embedding treatment, and the primary embedding particles were collected by spray drying.

[0029] Then, sodium alginate is selected as the second layer embedding wall material to perform a secondary embedding treatment on the first embedded particles.

[0030] Furthermore, the temperature of the primary embedding treatment is 35-45° C., and the spray drying speed is 3-5 mL / min.

[0031] Furthermore, the secondary embedding treatment temperature is 40-50° C., and the spray drying speed is 2-3 mL / min.

[0032] Through the above technical solution, this application uses a double-layer wall material of konjac extract and sodium alginate: the primary layer forms a sustained-release barrier in the stomach, protecting L-carnitine from gastric acid destruction; low temperature prevents high-temperature gelation of konjac glucomannan, ensuring uniform film formation of the wall material; the second layer, triggered by intestinal fluid pH, releases flaxseed diacylglycerol and nanoemulsion, targeting the absorption site in the small intestine. This process overcomes the release control limitations of single-layer encapsulation and achieves the time-series coordination of gastric sustained release and intestinal targeting.

[0033] In summary, this application has the following beneficial effects:

[0034] First, this application takes flaxseed diglyceride as the core, and combines konjac extract, L-carnitine, white kidney bean extract and green coffee extract to construct a multi-target weight regulation network. Flaxseed diglyceride activates the PPARα receptor and preferentially enters the mitochondrial β-oxidation pathway rather than the fat storage pathway; konjac extract enhances satiety by prolonging gastric emptying time; L-carnitine and flaxseed diglyceride synergistically promote the transport of fatty acids across the mitochondrial membrane, solving the rate-limiting bottleneck of carnitine palmitoyltransferase; white kidney bean extract inhibits the decomposition of carbohydrates into glucose, and green coffee extract activates the AMPK pathway to promote fat decomposition, forming a "fat-carbohydrate double blocking + energy consumption" synergistic effect. This combination breaks through the limitations of a single ingredient by regulating the entire chain of intake, absorption, and metabolism.

[0035] Second, this application further adds α-linolenic acid as an essential fatty acid, forming a complex with sn-1,3 flaxseed diglycerides. This enhances synergy through a dual mechanism: first, α-linolenic acid is converted into EPA / DHA by the liver, inhibiting lipase activity and reducing new fat production. Second, the ALA-DAG structure enhances intestinal lymphatic absorption, bypassing the portal vein first-pass effect and improving bioavailability. Furthermore, the microencapsulation uses sodium alginate as a wall material, which releases the product in a pH-responsive manner, preventing gastric acid from damaging the cis-double bond structure of α-linolenic acid.

[0036] Third, this application uses brown algae oligosaccharides as prebiotics, which promote the production of short-chain fatty acids by selectively proliferating beneficial bacteria such as bifidobacteria and lactic acid bacteria. Short-chain fatty acids activate intestinal L cells to secrete GLP-1, suppressing appetite and enhancing insulin sensitivity. At the same time, brown algae oligosaccharides and konjac glucomannan form a complex dietary fiber network, extending the duration of the gel barrier in the stomach and reducing calorie intake. Its low molecular weight ensures targeted fermentation in the colon and avoids premature degradation in the stomach.

[0037] Fourth, this application utilizes a double-layered encapsulation system of konjac extract and sodium alginate. The primary layer forms a sustained-release barrier in the stomach, protecting L-carnitine from gastric acid. Low temperatures prevent high-temperature gelation of the konjac glucomannan, ensuring uniform film formation. The secondary encapsulation layer, triggered by intestinal pH, releases flaxseed diacylglycerol and nanoemulsion, targeting absorption sites in the small intestine. This process overcomes the release control limitations of a single-layer encapsulation system, achieving a timed synergistic effect of sustained gastric release and intestinal targeting. DETAILED DESCRIPTION

[0038] The present application is further described in detail below with reference to the embodiments.

[0039] Among them, the sources of raw materials used in this application are as follows, and those not specified indicate analytically pure substances used in this application.

[0040] Flaxseed diglyceride: Shandong Tianmei Biotechnology Co., Ltd.;

[0041] Brown algae oligosaccharide: Qingdao Mingyue Seaweed Group;

[0042] White kidney bean extract: Sabinsa, USA;

[0043] Green coffee extract: Chlorogenic acid purity ≥98%: Shaanxi Jiahe Biotechnology.

[0044] Preparation Example 1

[0045] Flaxseed diglyceride 1

[0046] Flaxseed diglyceride was first distilled at 150°C and 3 MPa for 25 min.

[0047] The distillate is taken and subjected to secondary distillation at 200-220° C. and a pressure of 1 MPa for 25 minutes to prepare flaxseed diglyceride 1 having a sn-1,3 structure accounting for ≥85%.

[0048] Preparation Example 2

[0049] Flaxseed diglyceride 2

[0050] Flaxseed diglyceride was first distilled at 155°C and 4 MPa for 27 min.

[0051] The distillate was taken and placed under a secondary distillation treatment at 210° C. and a pressure of 2 MPa for 27 min to prepare flaxseed diglyceride 2 with a sn-1,3 structure accounting for ≥85%.

[0052] Preparation Example 3

[0053] Flaxseed diglyceride 3

[0054] Flaxseed diglyceride was first distilled at 160°C and 5 MPa for 30 min;

[0055] The distillate was taken and placed under a secondary distillation treatment at 220° C. and a pressure of 3 MPa for 30 min to prepare flaxseed diglyceride 3 having a sn-1,3 structure accounting for ≥85%.

[0056] Preparation Example 4

[0057] α-linolenic acid microcapsule powder 1

[0058] Linseed oil and sodium alginate were shear-emulsified in a mass ratio of 1:1, and the emulsion with a particle size of ≤50 μm was collected and placed in a spray drying device. The α-linolenic acid microcapsule powder 1 was prepared by spray drying at an inlet temperature of 150° C., an outlet temperature of 80° C., and an atomization pressure of 0.2 MPa.

[0059] Preparation Example 5

[0060] α-linolenic acid microcapsule powder 2

[0061] Linseed oil and sodium alginate were shear-emulsified in a mass ratio of 2:1, and the emulsion with a particle size of ≤50 μm was collected and placed in a spray drying device. The α-linolenic acid microcapsule powder 2 was prepared by spray drying at an inlet temperature of 165° C., an outlet temperature of 85° C., and an atomization pressure of 0.3 MPa.

[0062] Preparation Example 6

[0063] α-linolenic acid microcapsule powder 3

[0064] Linseed oil and sodium alginate were shear-emulsified in a mass ratio of 3:1, and the emulsion with a particle size of ≤50 μm was collected and placed in a spray drying device. The α-linolenic acid microcapsule powder 3 was prepared by spray drying at an inlet temperature of 180° C., an outlet temperature of 90° C., and an atomization pressure of 0.4 MPa.

[0065] Preparation Example 7

[0066] Konjac Extract (Phosphorylated Modified Glucomannan)

[0067] 700 g of glucomannan and 100 g of sodium hexametaphosphate were stirred and mixed and placed in 5000 g of water. After adjusting the pH to 3.0, the mixture was ultrasonically treated at 55° C. for 2 h, washed with 40% ethanol by mass until no free phosphorus remained, and dried at 80° C. to obtain the konjac extract.

[0068] Example 1

[0069] A diglyceride oil powder for weight management comprises the following substances: 18 kg of flaxseed diglyceride 1, 10 kg of konjac extract, 3 kg of L-carnitine, 3 kg of white kidney bean extract and 2 kg of green coffee extract.

[0070] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0071] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0072] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 1 and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 35°C and a spray drying rate of 3 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 40°C and a spray drying rate of 2 mL / min to embed the white kidney bean extract, linseed diglyceride 1 and nanoemulsion, and the embedded material was collected.

[0073] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0074] Example 2

[0075] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0076] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0077] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0078] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 45°C and a spray drying rate of 2 mL / min to embed the white kidney bean extract, linseed diglyceride 2, and nanoemulsion, and collect the embedded material.

[0079] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0080] Example 3

[0081] A diglyceride oil powder for weight management comprises the following substances: 30 kg of flaxseed diglyceride 3, 20 kg of konjac extract, 8 kg of L-carnitine, 8 kg of white kidney bean extract and 5 kg of green coffee extract.

[0082] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0083] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0084] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 3 and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 45°C and a spray drying rate of 5 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 50°C and a spray drying rate of 3 mL / min to embed white kidney bean extract, linseed diglyceride 3 and nanoemulsion, and the embedded material was collected.

[0085] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0086] Example 4

[0087] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 1 kg of α-linolenic acid microcapsule powder 1, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0088] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0089] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0090] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, α-linolenic acid microcapsule powder 1, and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 45°C and a spray drying rate of 2 mL / min to embed white kidney bean extract, linseed diglyceride 2, α-linolenic acid microcapsule powder 1, and nanoemulsion, and the embedded material was collected.

[0091] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0092] Example 5

[0093] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 3 kg of α-linolenic acid microcapsule powder 2, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0094] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0095] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0096] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, α-linolenic acid microcapsule powder 2, and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 45°C and a spray drying rate of 2 mL / min to embed the white kidney bean extract, linseed diglyceride 2, α-linolenic acid microcapsule powder 2, and nanoemulsion, and the embedded material was collected.

[0097] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0098] Example 6

[0099] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 5 kg of α-linolenic acid microcapsule powder 3, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0100] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0101] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0102] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, α-linolenic acid microcapsule powder 3, and nanoemulsion were subjected to a primary embedding treatment at a temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed at a temperature of 45°C and a spray drying rate of 2 mL / min to embed the white kidney bean extract, linseed diglyceride 2, α-linolenic acid microcapsule powder 3, and nanoemulsion, and the embedded material was collected.

[0103] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0104] Example 7

[0105] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 3 kg of α-linolenic acid microcapsule powder 2, 1 kg of brown algae oligosaccharide, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0106] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0107] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0108] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, brown algae oligosaccharide, α-linolenic acid microcapsule powder 2 and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 45°C and a spray drying rate of 2 mL / min to embed white kidney bean extract, linseed diglyceride 2, brown algae oligosaccharide, α-linolenic acid microcapsule powder 2 and nanoemulsion, and the embedded material was collected.

[0109] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0110] Example 8

[0111] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 3 kg of α-linolenic acid microcapsule powder 2, 4 kg of brown algae oligosaccharide, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0112] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0113] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0114] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, brown algae oligosaccharide, α-linolenic acid microcapsule powder 2 and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 45°C and a spray drying rate of 2 mL / min to embed white kidney bean extract, linseed diglyceride 2, brown algae oligosaccharide, α-linolenic acid microcapsule powder 2 and nanoemulsion, and the embedded material was collected.

[0115] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0116] Example 9

[0117] A diglyceride oil powder for weight management comprises the following substances: 23 kg of flaxseed diglyceride 2, 15 kg of konjac extract, 5 kg of L-carnitine, 3 kg of α-linolenic acid microcapsule powder 2, 8 kg of brown algae oligosaccharide, 5 kg of white kidney bean extract and 3 kg of green coffee extract.

[0118] A method for preparing diglyceride oil powder for weight management comprises the following steps:

[0119] L-carnitine and green coffee extract were mixed, 5 kg of soy lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion;

[0120] Phosphorylated modified glucomannan was selected as the primary embedding wall material, and white kidney bean extract, linseed diglyceride 2, brown algae oligosaccharide, α-linolenic acid microcapsule powder 2 and nanoemulsion were subjected to a primary embedding treatment at an embedding temperature of 40°C and a spray drying rate of 4 mL / min. After spray drying and collecting the primary embedded particles, a secondary embedding treatment was performed, which was adjusted to 45°C and a spray drying rate of 2 mL / min to embed white kidney bean extract, linseed diglyceride 2, brown algae oligosaccharide, α-linolenic acid microcapsule powder 2 and nanoemulsion, and the embedded material was collected.

[0121] The encapsulated material is then subjected to supercritical CO2-assisted spray drying at an inlet temperature of 50°C and a CO2 flow rate of 20 L / min. 0.5 kg of nano-silicon dioxide and 1 kg of microcrystalline cellulose are added, and the encapsulated material is fluidized bed coated at an inlet air temperature of 45°C and then packaged to prepare the diglyceride oil powder for weight management.

[0122] Comparative Example 1

[0123] Compared with Example 1, flaxseed diglyceride was not added in Comparative Example 1, and other ingredients were the same as those in Example 1.

[0124] Performance testing

[0125] The diglyceride oil powders prepared in Examples 1-9 and the weight management material prepared in Comparative Example 1 were subjected to performance testing, and the testing standards were as follows:

[0126] Fat oxidation rate: refer to INFOGEST 2.0 for in vitro fat digestion model test;

[0127] Intestinal targeted release rate: Release rate in simulated gastric fluid (pH 1.2, 2h) and intestinal fluid (pH 7.4, 6h);

[0128] Solubility: tested according to GB / T 19077-2016;

[0129] The test results are shown in Table 1 below:

[0130] Table 1 Performance test table

[0131]

[0132]

[0133] From the comparison of the results of Examples 1-9 and Comparative Example 1, it can be found that:

[0134] Comparison of Examples 1-3 with Comparative Example 1 further illustrates the construction of a multi-target weight regulation network based on flaxseed diglyceride, combined with konjac extract, L-carnitine, white kidney bean extract, and green coffee extract. By regulating the entire chain of intake, absorption, and metabolism, the application overcomes the limitations of a single ingredient.

[0135] Comparisons between Examples 1-3 and 4-6 further illustrate that the present invention's technical solution adds α-linolenic acid as an essential fatty acid, forming a complex with sn-1,3 flaxseed diglycerides. This enhances synergy through a dual mechanism: first, α-linolenic acid is converted into EPA / DHA by the liver, inhibiting lipase activity and reducing new fat production. Second, the ALA-DAG structure enhances intestinal lymphatic absorption, bypassing the portal vein first-pass effect and improving bioavailability. Furthermore, the microencapsulation utilizes sodium alginate as a wall material, enabling pH-responsive release to prevent gastric acid from damaging the cis-double bond structure of α-linolenic acid.

[0136] As further illustrated in conjunction with Examples 4-6 and 7-9, this application uses brown algae oligosaccharides as prebiotics to promote the production of short-chain fatty acids by selectively proliferating beneficial bacteria such as bifidobacteria and lactic acid bacteria. Short-chain fatty acids activate intestinal L cells to secrete GLP-1, suppressing appetite and enhancing insulin sensitivity. At the same time, brown algae oligosaccharides and konjac glucomannan form a composite dietary fiber network, extending the duration of the gel barrier in the stomach and reducing calorie intake. Its low molecular weight ensures targeted fermentation in the colon and avoids premature degradation in the stomach.

[0137] The present invention has been described in detail above with reference to specific embodiments and exemplary examples. However, these descriptions should not be construed as limiting the present invention. Those skilled in the art will appreciate that various equivalent substitutions, modifications, or improvements may be made to the technical solutions and implementations of the present invention without departing from the spirit and scope of the present invention, all of which fall within the scope of the present invention. The scope of protection of the present invention shall be determined by the appended claims.

[0138] All publications, patent applications, patents, and other references mentioned in this specification are incorporated herein by reference. Unless otherwise defined, all technical and scientific terms used in this specification have the meanings conventionally understood by those skilled in the art. In the event of conflict, the definitions in this specification shall prevail.

[0139] When this specification uses the prefix "well known to those skilled in the art", "prior art" or similar terms to introduce materials, substances, methods, steps, devices or components, the objects introduced by the prefix include those commonly used in the art when this application is filed, but also include those that are not commonly used at present but will become generally recognized in the art to be suitable for similar purposes.

[0140] In the context of this specification, any matters or items not mentioned are directly applicable to those known in the art without any changes except those explicitly stated.

Claims

1. A diglyceride oil powder for weight management, characterized in that: The composition includes the following materials in parts by weight: 18-30 parts of flaxseed diglyceride; 10-20 parts of konjac extract; 3-8 servings of L-carnitine; 3-8 parts of white kidney bean extract; 2-5 parts green coffee extract; The flaxseed diglyceride is a flaxseed diglyceride in which the sn-1,3 structure accounts for ≥85%.

2. The diglyceride oil powder for weight management according to claim 1, characterized in that: The flaxseed diglyceride with a sn-1,3 structure accounting for ≥85% is prepared using the following technical solution: Take linseed diglyceride and distill it at 150-160℃ and 3-5MPa for 25-30min; The distillate is taken and placed in a secondary distillation process at 200-220° C. and a pressure of 1-3 MPa for 25-30 minutes to prepare flaxseed diglyceride with a sn-1,3 structure accounting for ≥85%.

3. The diglyceride oil powder for weight management according to claim 1, characterized in that: The diglyceride oil powder for weight management further comprises 1-5 parts by weight of α-linolenic acid microcapsule powder.

4. The diglyceride oil powder for weight management according to claim 3, characterized in that: The α-linolenic acid microcapsule powder is prepared by the following technical solution: After linseed oil and sodium alginate are sheared and emulsified, the emulsion is collected and placed in a spray drying device for spray drying to prepare the α-linolenic acid microcapsule powder.

5. The diglyceride oil powder for weight management according to claim 3, characterized in that: The diglyceride oil powder for weight management further comprises 1-8 parts by weight of brown algae oligosaccharide.

6. The diglyceride oil powder for weight management according to claim 1, characterized in that: The konjac extract is phosphorylated modified glucomannan.

7. The method for preparing diglyceride oil powder for weight management according to any one of claims 1 to 6, characterized in that: The method comprises the following preparation steps: L-carnitine, green coffee extract and α-linolenic acid microcapsule powder were mixed, soybean lecithin was added, and high-pressure homogenization was performed at a pressure of 80 MPa to form a nanoemulsion; Konjac extract and sodium alginate were used as double-layer wall materials, and white kidney bean extract, brown algae oligosaccharide, linseed diglyceride and nanoemulsion were embedded respectively through gradient embedding process; After supercritical CO2-assisted spray drying, nano-silicon dioxide and microcrystalline cellulose are added, and the mixture is fluidized bed coated and then packaged to prepare the diglyceride oil powder for weight management.

8. The method for preparing diglyceride oil powder for weight management according to claim 7, characterized in that: The gradient embedding process adopts the following technical solutions: Phosphorylated modified glucomannan was selected as the primary embedding wall material, white kidney bean extract, linseed diglyceride and nanoemulsion were subjected to a primary embedding treatment, and the primary embedding particles were collected by spray drying. Then, sodium alginate is selected as the second layer embedding wall material to perform a secondary embedding treatment on the first embedded particles.

9. The method for preparing diglyceride oil powder for weight management according to claim 8, characterized in that: The temperature of the primary embedding treatment is 35-45° C., and the spray drying speed is 3-5 mL / min.

10. The method for preparing diglyceride oil powder for weight management according to claim 8, characterized in that: The secondary embedding treatment temperature is 40-50° C., and the spray drying speed is 2-3 mL / min.

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