A diglyceride oil powder for weight management and its preparation method

Abstract

This invention relates to the technical field of weight management, and in particular to a diglyceride oil powder for weight management and its preparation method. The diglyceride oil powder for weight management comprises the following components by weight: 18-30 parts flaxseed diglyceride; 10-20 parts konjac extract; 3-8 parts L-carnitine; 3-8 parts white kidney bean extract; and 2-5 parts green coffee extract; wherein the flaxseed diglyceride is a flaxseed diglyceride with a sn-1,3 structure comprising ≥85%. This application uses flaxseed diglyceride as the core, combined with konjac extract, L-carnitine, white kidney bean extract, and green coffee extract, to construct a multi-target weight regulation network. This forms a synergistic effect of "fat-carbohydrate dual blocking + energy consumption." This combination overcomes the limitations of single-component effects by regulating the entire process of intake, absorption, and metabolism.

Description

Technical Field

[0001] This invention relates to the technical field of weight management, and in particular to a diglyceride oil powder for weight management and its preparation method. Background Technology

[0002] Traditional weight management methods mainly rely on diet control, exercise intervention, and drug therapy, but they have significant limitations: adherence to diet and exercise programs is low, and long-term effects are difficult to maintain; while drug intervention can inhibit fat absorption, it is accompanied by gastrointestinal side effects, and rebound is common after discontinuation; although surgery can achieve rapid weight loss, it carries high risks of trauma and is expensive. In recent years, functional foods have gradually become a research hotspot due to their natural and safe characteristics, but their development still faces a core problem—how to achieve sustainable fat loss through precise metabolic regulation, rather than simply relying on calorie restriction. Existing meal replacement products mostly use high-fiber or protein blends, which can increase satiety in the short term, but lack targeted regulation of key pathways in fat metabolism, resulting in limited reduction in body fat percentage and failing to improve metabolic indicators such as insulin sensitivity.

[0003] Regarding the aforementioned technologies, the inventors discovered that current research on functional ingredients for weight management mainly focuses on three areas: regulation of fat metabolism, inhibition of carbohydrate absorption, and promotion of energy expenditure. Although these ingredients have shown potential in in vitro experiments, their practical application effectiveness is significantly reduced due to technological limitations. Existing compound formulations mostly employ simple physical mixing, lacking synergistic design between ingredients. Most products target only a single metabolic pathway, lacking systematic intervention across the entire "intake-absorption-storage-consumption" chain, resulting in slow reduction of body fat percentage. Secondly, the stability and delivery efficiency of functional ingredients for weight management are insufficient. High-temperature processing leads to an activity loss rate of over 40% for heat-sensitive ingredients; fat-soluble ingredients have poor compatibility with aqueous media, easily separating after reconstitution with cold water, resulting in an actual absorption rate of less than 50%. Summary of the Invention

[0004] To address the shortcomings of existing weight management functional ingredients, such as limited metabolic regulation and insufficient stability and delivery efficiency, this application provides a diglyceride oil powder for weight management and its preparation method.

[0005] In a first aspect, this application provides a diglyceride oil powder for weight management, employing the following technical solution:

[0006] A weight management diglyceride oil powder comprises the following components by weight: 18-30 parts flaxseed diglyceride; 10-20 parts konjac extract; 3-8 parts L-carnitine; 3-8 parts white kidney bean extract; 2-5 parts green coffee extract; wherein the flaxseed diglyceride is a flaxseed diglyceride with a sn-1,3 structure accounting for ≥85%.

[0007] Through the above technical solution, this application constructs a multi-target weight regulation network with flaxseed diglyceride as the core, combined with konjac extract, L-carnitine, white kidney bean extract, and green coffee extract. Flaxseed diglyceride activates PPARα receptors, preferentially entering the mitochondrial β-oxidation pathway rather than the fat storage pathway; konjac extract enhances satiety by prolonging gastric emptying time; L-carnitine synergistically promotes fatty acid transmitochondrial membrane transport with flaxseed diglyceride, overcoming the rate-limiting bottleneck of carnitine palmitoyltransferase; white kidney bean extract inhibits carbohydrate breakdown into glucose, and green coffee extract activates the AMPK pathway to promote fat breakdown, forming a synergistic effect of "fat-carbohydrate dual blockade + energy consumption." This combination overcomes the limitations of single-component effects by regulating the entire pathway of intake, absorption, and metabolism.

[0008] Furthermore, the flaxseed diglyceride with a sn-1,3 structure content of ≥85% is prepared using the following technical solution:

[0009] First, place the flaxseed diglyceride in a 150-160℃, 3-5MPa pressure environment for distillation for 25-30 minutes.

[0010] Flaxseed diglyceride with a sn-1,3 structure content ≥85% can be prepared by taking the distillate and subjecting it to two-stage distillation at 200-220℃ and 1-3MPa for 25-30 minutes.

[0011] Through the above technical solution, this application achieves precise enrichment of sn-1,3 structures using a two-stage molecular distillation process. The first stage of distillation removes free fatty acids and low-molecular-weight impurities, reducing the acid value; the second stage of distillation selectively evaporates residual sn-1,2 isomers based on the boiling point difference between sn-1,3 and sn-1,2 structures. This process overcomes the temperature limitations of traditional distillation, suppresses high-temperature oxidation side reactions through high pressure, and reduces thermal decomposition by utilizing the high vacuum of molecular distillation.

[0012] Furthermore, the weight management diglyceride oil powder also includes 1-5 parts by weight of α-linolenic acid microcapsule powder.

[0013] Through the above technical solution, this application further adds α-linolenic acid as an essential fatty acid, which forms a complex with flaxseed diglycerides with a sn-1,3 structure, enhancing efficacy through a dual mechanism: firstly, α-linolenic acid is converted to EPA / DHA in the liver, inhibiting lipase activity and reducing new fat formation; secondly, the ALA-DAG structure enhances the small intestinal lymphatic absorption pathway, bypassing the portal vein first-pass effect and improving bioavailability. Simultaneously, this microencapsulation uses sodium alginate as the wall material, releasing α-linolenic acid in a pH-responsive manner, avoiding the destruction of the cis-double bond structure of α-linolenic acid by gastric acid.

[0014] Furthermore, the α-linolenic acid microcapsule powder is prepared using the following technical solution:

[0015] After shearing and emulsifying flaxseed oil and sodium alginate, the emulsion is collected and placed in a spray drying device for spray drying to prepare the α-linolenic acid microcapsule powder.

[0016] Through the above technical solution, this application achieves efficient encapsulation of α-linolenic acid using a spray drying process with sodium alginate as the wall material. During the shear emulsification stage, a stable emulsion is formed, and sodium alginate binds to the hydrophobic ends of α-linolenic acid through its carboxyl groups, forming a bilayer structure. During the spray drying stage, the film-forming properties of sodium alginate are utilized for rapid dehydration, forming porous microcapsules. Compared to traditional gelatin encapsulation, sodium alginate microcapsules offer superior targeting.

[0017] Furthermore, the weight management diglyceride oil powder also includes 1-8 parts by weight of fucoidan oligosaccharides.

[0018] Through the above technical solution, this application selects fucoidan as a prebiotic, which promotes the production of short-chain fatty acids by selectively proliferating beneficial bacteria such as Bifidobacteria and Lactobacillus. Short-chain fatty acids activate intestinal L cells to secrete GLP-1, suppressing appetite and enhancing insulin sensitivity. Simultaneously, fucoidan and konjac glucomannan form a complex dietary fiber network, prolonging the duration of the gastric gel barrier and reducing calorie intake. Its low molecular weight ensures colon-targeted fermentation, preventing premature degradation in the stomach.

[0019] Furthermore, the konjac extract is phosphorylated modified glucomannan.

[0020] Through the above technical solution, this application selects phosphorylated modified glucomannan. After modification, the solubility is further improved, and the hydrogen bonding between the acid groups and water molecules further increases the viscosity, expanding the gel volume in the stomach and prolonging the duration of satiety. Furthermore, phosphorylation modification endows it with resistance to enzymatic degradation, reducing its degradation rate in a pepsin-rich environment.

[0021] Secondly, this application provides a method for preparing diglyceride oil powder for weight management, using the following technical solution:

[0022] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0023] L-carnitine, green coffee extract and α-linolenic acid microcapsule powder were mixed and soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0024] Using konjac extract and sodium alginate as bilayer wall materials, white kidney bean extract, brown algae oligosaccharide, flaxseed diglyceride and nanoemulsion were encapsulated through gradient encapsulation treatment.

[0025] After supercritical CO2-assisted spray drying, nano-silica and microcrystalline cellulose are added, and the mixture is fluidized bed coated and packaged to prepare the diglyceride oil powder for weight management.

[0026] This application solves the compatibility problem of fat-soluble and water-soluble components by nano-sizing L-carnitine, green coffee extract, α-linolenic acid and flaxseed diglyceride through high-pressure homogenization. At the same time, supercritical CO2-assisted spray drying reduces the loss of heat-sensitive components.

[0027] Furthermore, the gradient embedding process employs the following technical solution:

[0028] Phosphorylated modified glucomannan was selected as the primary encapsulation wall material to encapsulate white kidney bean extract, flaxseed diglyceride and nanoemulsion in one step, and the encapsulated particles were collected by spray drying.

[0029] Sodium alginate was then selected as the second-layer embedding wall material to perform a second embedding treatment on the first-layer embedded particles.

[0030] Furthermore, the temperature of the first embedding treatment is 35-45℃, and the spray drying rate is 3-5mL / min.

[0031] Furthermore, the secondary embedding treatment temperature is 40-50℃, and the spray drying rate is 2-3 mL / min.

[0032] Through the above technical solution, this application employs a double-layer wall material of konjac extract and sodium alginate: the primary layer encapsulates to form a gastric sustained-release barrier, protecting L-carnitine from gastric acid degradation; low temperature prevents high-temperature gelation of konjac glucomannan, ensuring uniform film formation; the secondary layer encapsulates to release flaxseed diglycerides and nanoemulsions triggered by intestinal pH, targeting the absorption sites in the small intestine. This process overcomes the limitations of single-layer encapsulation in release control, achieving temporal synergy between gastric sustained release and intestinal targeting.

[0033] In summary, this application has the following beneficial effects:

[0034] First, this application uses flaxseed diglyceride as the core ingredient, combined with konjac extract, L-carnitine, white kidney bean extract, and green coffee extract to construct a multi-target weight regulation network. Flaxseed diglyceride activates PPARα receptors, preferentially entering the mitochondrial β-oxidation pathway rather than the fat storage pathway; konjac extract enhances satiety by prolonging gastric emptying time; L-carnitine synergistically promotes fatty acid transmitochondrial membrane transport with flaxseed diglyceride, overcoming the rate-limiting bottleneck of carnitine palmitoyltransferase; white kidney bean extract inhibits carbohydrate breakdown into glucose, and green coffee extract activates the AMPK pathway to promote fat breakdown, forming a synergistic effect of "fat-carbohydrate dual blockade + energy consumption." This combination overcomes the limitations of single-component effects by regulating the entire pathway of intake, absorption, and metabolism.

[0035] Secondly, this application further adds α-linolenic acid as an essential fatty acid, which forms a complex with flaxseed diglycerides with a sn-1,3 structure, enhancing its efficacy through a dual mechanism: firstly, α-linolenic acid is converted to EPA / DHA in the liver, inhibiting lipase activity and reducing new fat production; secondly, the ALA-DAG structure enhances the small intestinal lymphatic absorption pathway, bypassing the portal vein first-pass effect and improving bioavailability. Simultaneously, this microencapsulation uses sodium alginate as the wall material, releasing α-linolenic acid in a pH-responsive manner, avoiding the destruction of the cis-double bond structure of α-linolenic acid by gastric acid.

[0036] Third, this application selects fucoidan oligosaccharides as a prebiotic, which promotes the production of short-chain fatty acids by selectively proliferating beneficial bacteria such as Bifidobacteria and Lactobacillus. Short-chain fatty acids activate intestinal L cells to secrete GLP-1, suppressing appetite and enhancing insulin sensitivity; at the same time, fucoidan oligosaccharides and konjac glucomannan form a complex dietary fiber network, prolonging the duration of the gastric gel barrier and reducing calorie intake. Its low molecular weight characteristics ensure colon-targeted fermentation, avoiding premature degradation in the stomach.

[0037] Fourth, this application employs a double-layer wall material of konjac extract and sodium alginate: the primary layer encapsulates to form a gastric sustained-release barrier, protecting L-carnitine from gastric acid degradation; low temperature prevents high-temperature gelation of konjac glucomannan, ensuring uniform film formation; the secondary layer encapsulates flaxseed diglycerides and nanoemulsions triggered by intestinal pH, targeting absorption sites in the small intestine. This process overcomes the limitations of single-layer encapsulation in release control, achieving temporal synergy between gastric sustained release and intestinal targeting. Detailed Implementation

[0038] The present application will be further described in detail below with reference to the embodiments.

[0039] The sources of raw materials used in this application are shown below. Unless otherwise specified, they are analytically pure substances used in this application.

[0040] Flaxseed diglyceride: Shandong Tianmei Biotechnology Co., Ltd.;

[0041] Brown algae oligosaccharides: Qingdao Mingyue Seaweed Group;

[0042] White kidney bean extract: Sabinsa Pharmaceuticals, USA;

[0043] Green coffee extract: Chlorogenic acid purity ≥ 98%: Shaanxi Jiahe Biotechnology.

[0044] Preparation Example 1

[0045] Flaxseed diglyceride 1

[0046] Flaxseed diglyceride was first placed at 150℃ and 3MPa pressure for 25 minutes for distillation.

[0047] Flaxseed diglyceride 1 with a sn-1,3 structure content ≥85% can be prepared by taking the distillate and subjecting it to two-stage distillation at 200-220℃ and 1MPa for 25 minutes.

[0048] Preparation Example 2

[0049] Flaxseed diglyceride 2

[0050] Flaxseed diglyceride was first distilled at 155℃ and 4MPa for 27 minutes.

[0051] Flaxseed diglyceride 2 with a sn-1,3 structure content ≥85% can be prepared by taking the distillate and subjecting it to two-stage distillation at 210℃ and 2MPa for 27min.

[0052] Preparation Example 3

[0053] Flaxseed diglyceride 3

[0054] Flaxseed diglyceride was first placed at 160℃ and 5MPa for 30 minutes for distillation.

[0055] Flaxseed diglyceride 3 with a sn-1,3 structure content ≥85% can be prepared by taking the distillate and subjecting it to secondary distillation at 220℃ and 3MPa for 30 min.

[0056] Preparation Example 4

[0057] α-Linolenic acid microcapsule powder 1

[0058] Flaxseed oil and sodium alginate were sheared and emulsified at a mass ratio of 1:1. The emulsion with a particle size ≤50μm was collected and placed in a spray drying device. The α-linolenic acid microcapsule powder 1 was prepared by spray drying at an inlet temperature of 150℃, an outlet temperature of 80℃, and an atomization pressure of 0.2MPa.

[0059] Preparation Example 5

[0060] α-Linolenic acid microcapsule powder 2

[0061] Flaxseed oil and sodium alginate were sheared and emulsified at a mass ratio of 2:1. The emulsion with a particle size ≤50μm was collected and placed in a spray drying device. The α-linolenic acid microcapsule powder 2 was prepared by spray drying at an inlet temperature of 165℃, an outlet temperature of 85℃, and an atomization pressure of 0.3MPa.

[0062] Preparation Example 6

[0063] α-Linolenic acid microcapsule powder 3

[0064] Flaxseed oil and sodium alginate were sheared and emulsified at a mass ratio of 3:1. The emulsion with a particle size ≤50μm was collected and placed in a spray drying device. The α-linolenic acid microcapsule powder 3 was prepared by spray drying at an inlet temperature of 180℃, an outlet temperature of 90℃, and an atomization pressure of 0.4MPa.

[0065] Preparation Example 7

[0066] Konjac extract (phosphorylated modified glucomannan)

[0067] Take 700g glucomannan and 100g sodium hexametaphosphate, stir and mix them, and place them in 5000g water. After adjusting the pH to 3.0, sonicate at 55℃ for 2h, wash with 40% ethanol until no free phosphorus residue remains, and dry at 80℃ to obtain konjac extract.

[0068] Example 1

[0069] A weight management diglyceride oil powder comprising the following substances: 18 kg flaxseed diglyceride, 10 kg konjac extract, 3 kg L-carnitine, 3 kg white kidney bean extract and 2 kg green coffee extract.

[0070] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0071] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0072] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 1, and nanoemulsion. The encapsulation temperature was 35℃, and the spray drying rate was 3mL / min. After collecting the encapsulated particles by spray drying, a second encapsulation process was performed at 40℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 1, and nanoemulsion. The encapsulated material was then collected.

[0073] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0074] Example 2

[0075] A weight management diglyceride oil powder comprising the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 5 kg white kidney bean extract and 3 kg green coffee extract.

[0076] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0077] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0078] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a secondary encapsulation process was performed at 45℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, and nanoemulsion. The encapsulated material was then collected.

[0079] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0080] Example 3

[0081] A weight management diglyceride oil powder comprising the following substances: 30 kg flaxseed diglyceride, 20 kg konjac extract, 8 kg L-carnitine, 8 kg white kidney bean extract and 5 kg green coffee extract.

[0082] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0083] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0084] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 3, and nanoemulsion. The encapsulation temperature was 45℃, and the spray drying rate was 5mL / min. After collecting the encapsulated particles by spray drying, a second encapsulation process was performed at 50℃ with a spray drying rate of 3mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 3, and nanoemulsion. The encapsulated material was then collected.

[0085] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0086] Example 4

[0087] A weight management diglyceride oil powder comprises the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 1 kg α-linolenic acid microcapsule powder, 5 kg white kidney bean extract, and 3 kg green coffee extract.

[0088] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0089] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0090] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, α-linolenic acid microcapsule powder 1, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a secondary encapsulation process was performed at 45℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, α-linolenic acid microcapsule powder 1, and nanoemulsion. The encapsulated material was then collected.

[0091] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0092] Example 5

[0093] A weight management diglyceride oil powder comprises the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 3 kg α-linolenic acid microcapsule powder, 5 kg white kidney bean extract, and 3 kg green coffee extract.

[0094] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0095] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0096] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a secondary encapsulation process was performed at 45℃ and the spray drying rate was 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulated material was then collected.

[0097] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0098] Example 6

[0099] A weight management diglyceride oil powder comprises the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 5 kg α-linolenic acid microcapsule powder, 5 kg white kidney bean extract, and 3 kg green coffee extract.

[0100] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0101] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0102] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, α-linolenic acid microcapsule powder 3, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a secondary encapsulation process was performed at 45℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, α-linolenic acid microcapsule powder 3, and nanoemulsion. The encapsulated material was then collected.

[0103] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0104] Example 7

[0105] A weight management diglyceride oil powder comprises the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 3 kg α-linolenic acid microcapsule powder, 1 kg brown algae oligosaccharide, 5 kg white kidney bean extract, and 3 kg green coffee extract.

[0106] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0107] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0108] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, fucoidan oligosaccharide, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a second encapsulation process was performed at 45℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, fucoidan oligosaccharide, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulated material was then collected.

[0109] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0110] Example 8

[0111] A weight management diglyceride oil powder comprises the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 3 kg α-linolenic acid microcapsule powder, 4 kg brown algae oligosaccharide, 5 kg white kidney bean extract, and 3 kg green coffee extract.

[0112] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0113] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0114] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, fucoidan oligosaccharide, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a second encapsulation process was performed at 45℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, fucoidan oligosaccharide, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulated material was then collected.

[0115] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0116] Example 9

[0117] A weight management diglyceride oil powder comprises the following substances: 23 kg flaxseed diglyceride, 15 kg konjac extract, 5 kg L-carnitine, 3 kg α-linolenic acid microcapsule powder, 8 kg brown algae oligosaccharide, 5 kg white kidney bean extract, and 3 kg green coffee extract.

[0118] A method for preparing diglyceride oil powder for weight management includes the following preparation steps:

[0119] L-carnitine and green coffee extract were mixed, and 5 kg of soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion.

[0120] Phosphorylated modified glucomannan was selected as the primary embedding wall material to encapsulate white kidney bean extract, flaxseed diglyceride 2, fucoidan oligosaccharide, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulation temperature was 40℃, and the spray drying rate was 4mL / min. After collecting the encapsulated particles by spray drying, a second encapsulation process was performed at 45℃ with a spray drying rate of 2mL / min to encapsulate white kidney bean extract, flaxseed diglyceride 2, fucoidan oligosaccharide, α-linolenic acid microcapsule powder 2, and nanoemulsion. The encapsulated material was then collected.

[0121] After supercritical CO2-assisted spray drying of the embedded material at an inlet temperature of 50℃ and a CO2 flow rate of 20L / min, 0.5kg of nano-silica and 1kg of microcrystalline cellulose are added, and the mixture is then coated in a fluidized bed at an inlet air temperature of 45℃ and packaged to obtain the diglyceride oil powder for weight management.

[0122] Comparative Example 1

[0123] Compared with Example 1, Comparative Example 1 did not contain flaxseed diglyceride, but the other components were the same as in Example 1.

[0124] Performance testing

[0125] The performance of the diglyceride oil powder prepared in Examples 1-9 and the weight management substance prepared in Comparative Example 1 were tested according to the following standards:

[0126] Fat oxidation rate: In vitro fat digestion model test was conducted with reference to INFOGEST 2.0;

[0127] Intestinal-targeted release rate: Release rate in simulated gastric juice (pH 1.2, 2h) and intestinal juice (pH 7.4, 6h);

[0128] Instant solubility: tested according to standard GB / T 19077-2016;

[0129] The test results are shown in Table 1 below:

[0130] Table 1 Performance Test Table

[0131]

[0132]

[0133] Comparing the results of Examples 1-9 and Comparative Example 1 above, it can be found that:

[0134] Examples 1-3, compared with Comparative Example 1, further illustrate that this application uses flaxseed diglyceride as the core, combined with konjac extract, L-carnitine, white kidney bean extract, and green coffee extract to construct a multi-target weight regulation network. By regulating the entire pathway of intake, absorption, and metabolism, it overcomes the limitations of single-component effects.

[0135] By comparing Examples 1-3 and Examples 4-6, it is further illustrated that the technical solution of this application adds α-linolenic acid as an essential fatty acid, which forms a complex with flaxseed diglycerides with a sn-1,3 structure. This complex enhances the effect through a dual mechanism: firstly, α-linolenic acid is converted to EPA / DHA in the liver, inhibiting lipase activity and reducing new fat production; secondly, the ALA-DAG structure enhances the small intestinal lymphatic absorption pathway, bypassing the portal vein first-pass effect and improving bioavailability. Simultaneously, the microencapsulation uses sodium alginate as the wall material, releasing the α-linolenic acid in a pH-responsive manner, preventing gastric acid from damaging the cis-double bond structure.

[0136] Further explanation based on Examples 4-6 and 7-9 illustrates that this application selects fucoidan oligosaccharides as a prebiotic, which promotes the production of short-chain fatty acids by selectively proliferating beneficial bacteria such as Bifidobacteria and Lactobacillus. Short-chain fatty acids activate intestinal L cells to secrete GLP-1, suppressing appetite and enhancing insulin sensitivity. Simultaneously, fucoidan oligosaccharides and konjac glucomannan form a complex dietary fiber network, prolonging the duration of the gastric gel barrier and reducing calorie intake. Its low molecular weight ensures colon-targeted fermentation, preventing premature degradation in the stomach.

[0137] The present invention has been described in detail above with reference to specific embodiments and exemplary examples; however, these descriptions should not be construed as limiting the present invention. Those skilled in the art will understand that various equivalent substitutions, modifications, or improvements can be made to the technical solutions and embodiments of the present invention without departing from the spirit and scope of the invention, and all such modifications and improvements fall within the scope of the present invention. The scope of protection of the present invention is defined by the appended claims.

[0138] All publications, patent applications, patents, and other references mentioned in this specification are incorporated herein by reference. Unless otherwise defined, all technical and scientific terms used in this specification have the meanings commonly understood by those skilled in the art. In case of conflict, the definitions in this specification shall prevail.

[0139] When this specification uses the prefixes “known to those skilled in the art,” “prior art,” or similar terms to derive materials, substances, methods, steps, apparatus, or components, the objects derived from such prefixes cover those commonly used in the art at the time of this application, but also include those that are not currently commonly used but will become generally recognized in the art as suitable for similar purposes.

[0140] In the context of this specification, except where expressly stated otherwise, any matters or issues not mentioned shall apply directly to those known in the art without any modification.

Claims

1. A diglyceride oil powder for weight management, characterized in that, Includes the following substances by weight: Flaxseed diglyceride 18-30 parts; 10-20 parts of konjac extract; L-carnitine 3-8 parts; 3-8 parts of white kidney bean extract; 2-5 parts green coffee extract; The flaxseed diglyceride is a flaxseed diglyceride with a sn-1,3 structure content of ≥85%; the flaxseed diglyceride with a sn-1,3 structure content of ≥85% is prepared by the following method: First, place the flaxseed diglyceride in a 150-160℃, 3-5MPa pressure environment for distillation for 25-30 minutes. The distillate is subjected to secondary distillation at 200-220℃ and 1-3MPa for 25-30 minutes to prepare flaxseed diglyceride with a sn-1,3 structure ratio ≥85%. The konjac extract is a phosphorylated glucomannan.

2. The diglyceride oil powder for weight management according to claim 1, characterized in that, The weight management diglyceride oil powder also includes 1-5 parts by weight of α-linolenic acid microcapsule powder.

3. The diglyceride oil powder for weight management according to claim 2, characterized in that, The α-linolenic acid microcapsule powder is prepared by the following method: After shearing and emulsifying flaxseed oil and sodium alginate, the emulsion is collected and placed in a spray drying device for spray drying to prepare the α-linolenic acid microcapsule powder.

4. The diglyceride oil powder for weight management according to claim 2, characterized in that, The weight management diglyceride oil powder also includes 1-8 parts by weight of fucoidan oligosaccharides.

5. The method for preparing a diglyceride oil powder for weight management according to claim 4, characterized in that, The preparation steps include the following: L-carnitine, green coffee extract and α-linolenic acid microcapsule powder were mixed and soybean lecithin was added. The mixture was then homogenized under high pressure at 80 MPa to form a nanoemulsion. Using konjac extract and sodium alginate as bilayer wall materials, white kidney bean extract, brown algae oligosaccharide, flaxseed diglyceride and nanoemulsion were encapsulated through gradient encapsulation treatment. After supercritical CO2-assisted spray drying, nano-silica and microcrystalline cellulose are added, followed by fluidized bed coating and packaging to prepare the diglyceride oil powder for weight management; the gradient encapsulation process includes the following steps: Phosphorylated modified glucomannan was selected as the primary encapsulation wall material to encapsulate white kidney bean extract, flaxseed diglyceride and nanoemulsion in one step, and the encapsulated particles were collected by spray drying. Sodium alginate was then selected as the second-layer embedding wall material to perform a second embedding treatment on the first-layer embedded particles. The temperature of the first embedding treatment was 35-45℃, and the spray drying rate was 3-5 mL / min. The temperature of the second embedding treatment was 40-50℃, and the spray drying rate was 2-3 mL / min.

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