Hair growing and nourishing gel as well as preparation method and application thereof

Abstract

The invention relates to the technical field of daily chemical products, in particular to hair growing and nourishing gel and a preparation method and application thereof.The hair growing and nourishing gel is prepared from 20-40 parts of royal jelly, 6-18 parts of cacumen biotae, 6-18 parts of rhizoma smilacis glabrae, 6-18 parts of radix sophorae flavescentis, 6-18 parts of radix salviae miltiorrhizae, 0.2-0.5 part of carbomer, 1.3-6 parts of glycerinum, 1.3-6 parts of propylene glycol, 0.2 part of azone and 0.5-1.5 parts of vitamin E, the hair-growing and hair-nourishing gel provided by the invention adopts a traditional Chinese medicine syndrome differentiation thought, is specially used for treating damp-heat type alopecia, and has the effects of growing hair, blackening hair, clearing damp and removing fat through a monarch, minister, assistant and guide compatibility thought.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemical products, and in particular to a hair growth and nourishing gel, a preparation method and an application thereof. Background Art

[0002] In today's society, hair loss has gradually become a common disease due to mental stress, dietary preferences, sleep problems, and other reasons caused by work and life. Androgenic alopecia is the most common type of hair loss. According to epidemiological surveys, the prevalence rate among men in my country is approximately 21.3%, and the prevalence rate among women is approximately 6.0%. The overall prevalence of familial AGA is 72.8%, and it is mostly inherited from the father. Although hair does not have any key physiological functions in the eyes of modern people and does not directly affect physical health, with the development of the times and the improvement of aesthetic awareness, people are paying more attention to disfiguring diseases such as hair loss and acne. These diseases often cause psychological stress to patients because they affect their appearance and are difficult to cure, thus affecting their quality of life.

[0003] Western medicine treatments for androgenic alopecia often include medication, physical therapy, and surgery. Finasteride and minoxidil are commonly used in Western medicine treatments. Although medications can effectively treat hair loss, studies have found that finasteride has adverse reactions, including erectile dysfunction, ejaculatory dysfunction, depression, anxiety, muscle atrophy, and male breast development. Minoxidil's adverse reactions mainly include scalp itching, contact dermatitis, and hirsutism. Compared with medication, medications such as low-intensity laser therapy and surgical treatments such as hair transplantation require the active cooperation of a professional medical team and the individual, which increases the difficulty and cost of treatment to a certain extent, making treatment expensive.

[0004] Therefore, there is an urgent need to develop safe hair growth agents without side effects. Summary of the Invention

[0005] To develop a safe and side-effect-free hair growth agent, the present invention provides a hair growth and nourishing gel, its preparation method, and its application. The hair growth and nourishing gel utilizes Traditional Chinese Medicine (TCM) syndrome differentiation principles, specifically targeting damp-heat-related hair loss. By formulating the formula with the principle of monarch, minister, assistant, and guiding ingredients, the gel promotes hair growth, darkens hair, dispels dampness, and removes fat, while increasing total hair density by up to 7.25%.

[0006] A hair growth and nourishing gel, wherein the components of the hair growth and nourishing gel are made of the following components by mass fraction: 20-40 parts of royal jelly, 6-18 parts of Platycladus orientalis leaves, 6-18 parts of Smilax glabra, 6-18 parts of Sophora flavescens, 6-18 parts of Salvia miltiorrhiza, 0.2-0.5 parts of carbomer, 1.3-6 parts of glycerin, 1.3-6 parts of propylene glycol, 0.2 parts of azone, and 0.5-1.5 parts of vitamin E.

[0007] The hair growth and nourishing gel provided by the present invention comprises royal jelly, Platycladus orientalis leaves, Smilax glabra, Sophora flavescens, and Salvia miltiorrhiza. The entire formula contains a small but highly specialized set of ingredients. Royal jelly is the main ingredient, capable of relieving pain and detoxifying, curing a wide range of illnesses, and harmonizing all other medicines. The "Compendium of Materia Medica" states that it is suitable for all ailments related to the mind, qi and blood, deficiency and excess, cold and heat, yin and yang, and internal and external conditions. Platycladus orientalis leaves are bitter, astringent, cold, and slightly pungent. They can cool the blood and stop bleeding, replenish qi and eliminate dampness. The Song Dynasty book "Rihuazi Bencao" states that they can "blacken and moisturize the temples," while the "Compendium of Materia Medica Congxin" states that they are "the most effective in clearing damp-heat from the blood," making them effective for treating hair loss caused by damp-heat. Sophora flavescens is bitter and cold. It clears heat and dampness, kills insects, and relieves itching. The two ingredients, combined as auxiliary ingredients, are specifically designed to clear heat and dampness. Smilax glabra is sweet, mild, and neutral. It detoxifies and removes dampness, and promotes joint circulation. Salvia miltiorrhiza is bitter and slightly cold. It promotes blood circulation and removes blood stasis, cools the blood and eliminates carbuncles, and relieves restlessness and calms the mind. The Jingyue Complete Works states that it nourishes and activates blood circulation, generates new blood, promotes the circulation of old blood, and promotes the growth of flesh and muscle. It can assist the auxiliary herbs in cooling blood and removing dampness, dispersing blood stasis and unblocking the meridians. The combination of the entire formula and the various herbs achieves a synergistic effect.

[0008] The hair growth and nourishing gel provided by this invention utilizes Traditional Chinese Medicine (TCM) syndrome differentiation to specifically treat damp-heat-related hair loss. Its formulation utilizes a combination of monarch, minister, assistant, and envoy ingredients, resulting in the gel's benefits of promoting hair growth, darkening hair, removing dampness, and eliminating fat. The gel, which uses pure natural royal jelly as the monarch ingredient, not only relieves pain and detoxifies, eliminates various diseases, and harmonizes various medicinal properties, but also increases total hair density by up to 7.25%, meeting the needs of modern consumers.

[0009] The present invention provides a method for preparing a hair growth and nourishing gel, comprising the following steps: S1. Mixing Platycladus orientalis leaves, Smilax glabra, Sophora flavescens, and Salvia miltiorrhiza to obtain a Chinese medicine mixture, heating the Chinese medicine mixture under reflux for extraction, and concentrating the extract under reduced pressure to obtain an extract; S2. mixing the royal jelly with the extract to obtain a mixed extract, adding ethanol solution to the mixed extract until the alcohol content in the mixed extract reaches 50% to 55%, filtering, and vacuum freeze-drying the filtrate to obtain a dry product; S3. Dissolve the dried product in 72% to 75% ethanol, add carbomer, glycerol, propylene glycol, azone, and vitamin E, and mix well to obtain a mixture. Then, add 1 to 1.2 times the mass of water of the mixture, let it stand until it swells, and adjust the pH to neutral to obtain the hair growth and nourishing gel.

[0010] Furthermore, in S1, the solvent for heating and refluxing is water, the mass of the water is 8 to 12 times the mass of the traditional Chinese medicine mixture, the extraction temperature is 83 to 86°C, the extraction time is 1.5 to 2 hours, and the number of extractions is 2 to 3 times.

[0011] Furthermore, the relative density of the extract is 1.05~1.25.

[0012] Furthermore, in S2, the volume fraction of the ethanol solution is 94% to 95%.

[0013] Furthermore, in S3, the dry product and ethanol are in an equal mass ratio.

[0014] Furthermore, triethanolamine was used to adjust the pH.

[0015] The present invention also provides the use of the hair growth and nourishing gel in preparing a medicine for improving the sub-healthy state of the scalp and hair.

[0016] Furthermore, the hair growth and nourishing gel can increase the total density of hair.

[0017] Compared with the prior art, the present invention has the following beneficial effects: The hair growth and nourishing gel provided by this invention utilizes Traditional Chinese Medicine (TCM) syndrome differentiation to specifically treat damp-heat-related hair loss. Its formulation utilizes a combination of monarch, minister, assistant, and envoy ingredients, resulting in the gel's benefits of promoting hair growth, darkening hair, removing dampness, and eliminating fat. The gel, which uses pure natural royal jelly as the monarch ingredient, not only relieves pain and detoxifies, eliminates various diseases, and harmonizes various medicinal properties, but also increases total hair density by up to 7.25%, meeting the needs of modern consumers.

[0018] The hair growth and nourishing gel provided by the present invention has stable properties, is easy to store, has a rapid effect, is easy to use and carry, and can accurately penetrate into the scalp hair follicles, activate hair follicle cells, promote scalp blood circulation, and provide sufficient nutrition for the hair follicles. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0020] Figure 1 This is a comparison of hair density of two hair loss patients in experimental group 1 before and after using the hair growth and nourishing gel of Example 1. A is patient 1 before use, B is patient 1 after use, C is patient 2 before use, and D is patient 2 after use. DETAILED DESCRIPTION

[0021] The specific embodiments of the present invention are described in detail below, but it should be understood that the scope of protection of the present invention is not limited by the specific embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of the present invention. The test methods described in the embodiments of the present invention are conventional methods unless otherwise specified, and the materials, reagents, etc. used in the following examples can be obtained from commercial sources unless otherwise specified.

[0022] Example 1: A hair growth and nourishing gel and a preparation method thereof.

[0023] The hair growth and nourishing gel of this embodiment is composed of traditional Chinese medicine ingredients and a gel matrix; The Chinese medicine ingredients are: royal jelly 30g, Platycladus orientalis leaves 12g, Smilax glabra 12g, Sophora flavescens 12g, and Salvia miltiorrhiza 12g.

[0024] The gel matrix consists of: carbomer 0.2g, glycerol 4g, propylene glycol 4g, azone 0.2g, and vitamin E 1.5g.

[0025] The preparation method of the hair growth and nourishing gel of this embodiment is as follows: 12g of Platycladus orientalis leaves, 12g of Smilax glabra, 12g of Sophora flavescens, and 12g of Salvia miltiorrhiza are taken, the medicines are crushed, 480ml of deionized water are added, and the mixture is soaked for 24h, and then heated to 83°C and refluxed for extraction 3 times, each time for 2 hours. The extracts are combined, concentrated under reduced pressure to an extract with a relative density of 1.15, mixed with 30g of royal jelly, and 95% ethanol is added dropwise until the alcohol content in the mixed extract reaches 55%, the filtrate is filtered, and vacuum freeze-dried; the dry product is dissolved in 75% ethanol in an equal mass ratio, 0.2g of carbomer, 4g of glycerol, 4g of propylene glycol, 0.2g of azone, and 1.5g of vitamin E are added and mixed evenly, then 82ml of pure water is added, and the mixture is allowed to stand until swelling, triethanolamine is added dropwise to adjust the pH to neutral, and mixed to obtain a hair growth and nourishing gel.

[0026] Example 2: A hair growth and nourishing gel and a preparation method thereof.

[0027] The hair nourishing gel of this embodiment is composed of traditional Chinese medicine ingredients and a gel matrix; The Chinese medicinal ingredients are: royal jelly 20g, Platycladus orientalis leaves 6g, Smilax glabra 6g, Sophora flavescens 6g, and Salvia miltiorrhiza 6g.

[0028] The gel matrix consists of: carbomer 0.1g, glycerol 1.3g, propylene glycol 1.3g, azone 0.2g, and vitamin E 0.5g.

[0029] The preparation method of the hair growth and nourishing gel of this embodiment is as follows: 6 g of Platycladus orientalis leaves, 6 g of Smilax glabra, 6 g of Sophora flavescens, and 6 g of Salvia miltiorrhiza are taken, the medicines are crushed, 240 mL of deionized water are added, and the mixture is soaked for 24 hours, and then heated to 80° C. and refluxed for extraction 3 times, each time for 2 hours. The extracts are combined and concentrated under reduced pressure to an extract with a relative density of 1.05, mixed with 20 g of royal jelly, and 95% ethanol is added dropwise until the alcohol content in the mixed extract reaches 55%. The filtrate is filtered and freeze-dried in vacuum; the dry product is dissolved in 75% ethanol in an equal mass ratio, 0.1 g of carbomer, 1.3 g of glycerol, 1.3 g of propylene glycol, 0.2 g of azone, and 0.5 g of vitamin E are added and mixed evenly, then 43 ml of pure water is added, and the mixture is allowed to stand until swelling occurs. After adding triethanolamine dropwise to adjust the pH to neutral, the mixture is mixed to obtain a hair growth and nourishing gel.

[0030] Example 3: A hair growth and nourishing gel and a preparation method thereof.

[0031] The hair growth and nourishing gel of this embodiment is composed of traditional Chinese medicine ingredients and a gel matrix; The Chinese medicinal ingredients are: royal jelly 40g, Platycladus orientalis leaves 18g, Smilax glabra 18g, Sophora flavescens 18g, and Salvia miltiorrhiza 18g.

[0032] The gel matrix consists of: carbomer 0.5g, glycerol 6g, propylene glycol 6g, azone 0.2g, and vitamin E 1.2g.

[0033] The preparation method of the hair growth and nourishing gel of this embodiment is as follows: 18g of Platycladus orientalis leaves, 18g of Smilax glabra, 18g of Sophora flavescens, and 18g of Salvia miltiorrhiza are taken, the medicines are crushed, 720ml of deionized water are added, and the mixture is soaked for 24h, and then heated to 85°C and refluxed for extraction 3 times, each time for 2 hours. The extracts are combined, concentrated under reduced pressure to an extract with a relative density of 1.25, mixed with 40g of royal jelly, and 95% ethanol is added dropwise until the alcohol content in the mixed extract reaches 55%, the filtrate is filtered, and vacuum freeze-dried; the dry product is dissolved in 75% ethanol in an equal mass ratio, 0.5g of carbomer, 6g of glycerin, 6g of propylene glycol, 0.2g of azone, and 1.2g of vitamin E are added and mixed evenly, then 98ml of pure water is added, and the mixture is allowed to stand until swelling occurs. Triethanolamine is added dropwise to adjust the pH to neutral, and the mixture is mixed to obtain a hair growth and nourishing gel.

[0034] The hair growth and anti-hair loss effect of the product of the present invention is demonstrated by taking the hair nourishing gel of Example 1 as an example. The specific test method and test results are as follows: 1. Test methods In order to illustrate the hair growth and nourishing gel prepared by the present invention, the following study was conducted using the hair growth and nourishing gel prepared in Example 1 of the present invention and the commercially available Zhangguang 101 hair growth liquid product as examples: The hair growth and hair loss prevention abilities of the hair growth and nourishing gel prepared by the present invention and the Zhangguang 101 hair growth liquid were evaluated. 90 volunteers were selected as test subjects, including 48 males and 42 females. Their hair loss levels were mild to moderate androgenic alopecia according to the BASP classification (M1-M2, C1, V1-V2, F1-F3). The age ratios of the test subjects were: 40% aged 18 to 35 years, 35% aged 35 to 50 years, and 25% aged 50 years and above.

[0035] The participants were divided into two groups: an experimental group (60 participants) and a control group (30 participants). The experimental group consisted of 32 males and 28 females. The experimental group was divided into two groups of 30: experimental group 1 and experimental group 2. Both groups consisted of 16 males and 14 females, with a relatively balanced gender ratio and age composition.

[0036] Patients in experimental group 1 used the hair growth and nourishing gel, while patients in experimental group 2 used the hair growth and nourishing stock solution (i.e., the combined extracts from Example 1). Application was scheduled once nightly, centered on the area of hair loss, and gently massaged for 4 minutes after application to promote drug absorption. Results were analyzed after 4 weeks of continuous use, and efficacy was determined over a total of 12 weeks. The control group consisted of 16 males and 14 females. The control group used Zhang Guang 101 hair growth solution once daily, and after 4 weeks of continuous use, efficacy was determined over a total of 12 weeks. The dosage of Zhang Guang 101 hair growth solution and hair growth and nourishing stock solution was 10 ml, and the dosage of hair growth and nourishing gel was 1 g.

[0037] The efficacy results are specifically divided into: Ineffective: There is almost no obvious new hair growth before and after use, or only a small amount of vellus hair grows, and hair loss still occurs.

[0038] Effective: With the use of the product, hair loss stops and more than 1 / 3 of fine, sparse hair gradually grows in the area where there was no hair originally.

[0039] Visible effect: With the use of the product, hair loss stops and more than 2 / 3 of black and white hair of uneven thickness gradually grows in the areas where there was no hair originally.

[0040] Total effective rate (%) = apparent effective rate + effective rate.

[0041] Density testing: The dermatoscope provided with the hair analysis system is fixed at the Baihui point and photographed at 70x magnification. The hair roots in the captured image are marked, and based on the number of marks, the system calculates the hair density.

[0042] 2. Test results: The results are shown in Table 1. After 12 weeks of using the hair growth and nourishing gel, the total effective rate of the 30 volunteers in the experimental group 1 was 86.7%. After 12 weeks of using the hair growth and nourishing liquid, the total effective rate of the 30 volunteers in the experimental group 2 was 83.3%. After 12 weeks of using the Zhangguang 101 hair growth liquid, the total effective rate of the 30 volunteers in the control group was 56.7%. The effectiveness of the experimental groups 1 and 2 was analyzed by chi-square test. P The values were all <0.05, indicating statistically significant differences, indicating that hair growth gel and hair growth solution are superior to Zhangguang 101 hair growth solution in the treatment of mild to moderate androgenic alopecia. Furthermore, hair growth gel is more effective than hair growth solution. This is because encapsulating the drug in a gel significantly increases its content in the skin and reduces its concentration in the systemic blood circulation. Furthermore, the gel formulation is easier and more convenient to use than the solution, leading to better patient compliance and ultimately better efficacy.

[0043] Table 1 Comparison of the effective rates of the experimental groups and the control group Note: - indicates that the data is not included.

[0044] From Table 2 and Figure 1 It can be seen that hair growth gel and original solution are superior to Zhang Guang 101 hair growth solution in terms of density growth rate in the treatment of mild to moderate androgenic alopecia.

[0045] Table 2 Comparison of hair growth effects between the experimental groups and the control group At the same time, this trial also observed and compiled the improvement in scalp oiliness and itching in 90 volunteers before and after the 12-week treatment period, using symptom and sign classification scores. Specific symptom and sign scores are shown in Table 3, and the results are shown in Tables 4 and 5.

[0046] Table 3 Symptom and sign classification scores Table 4 Comparison of greasiness Note: - indicates that the data is not included.

[0047] Table 5 Comparison of itching degree Note: - indicates that the data is not included.

[0048] The statistical results show that after 12 weeks of treatment, the improvement of scalp oiliness and itching by hair growth gel is statistically significant compared with Zhangguang 101 hair growth liquid ( P <0.01), hair growth and nourishing gel has a better symptomatic effect on damp-heat type hair loss.

[0049] The above results show that the various drugs in the hair growth and nourishing gel can work together to maximize their efficacy, nourish hair, improve local blood circulation to the scalp, and reduce oil secretion, thereby alleviating hair loss and nourishing hair development.

[0050] Although preferred embodiments of the present invention have been described, additional changes and modifications to these embodiments may occur to those skilled in the art once the basic inventive concepts become known.

[0051] Obviously, those skilled in the art may make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, if such modifications and variations fall within the scope of the claims and their equivalents, the present invention is intended to include such modifications and variations.

Claims

1. A hair growth and nourishing gel, characterized in that: The hair growth and nourishing gel is made of the following components: 20-40 parts of royal jelly, 6-18 parts of Platycladus orientalis leaves, 6-18 parts of Smilax glabra, 6-18 parts of Sophora flavescens, 6-18 parts of Salvia miltiorrhiza, 0.2-0.5 parts of carbomer, 1.3-6 parts of glycerin, 1.3-6 parts of propylene glycol, 0.2 parts of azone, and 0.5-1.5 parts of vitamin E.

2. A method for preparing the hair growth and nourishing gel according to claim 1, characterized in that: The steps include: S1. Mixing Platycladus orientalis leaves, Smilax glabra, Sophora flavescens, and Salvia miltiorrhiza to obtain a Chinese medicine mixture, heating the Chinese medicine mixture under reflux for extraction, and concentrating the extract under reduced pressure to obtain an extract; S2. mixing the royal jelly with the extract to obtain a mixed extract, adding ethanol solution to the mixed extract until the alcohol content in the mixed extract reaches 50% to 55%, filtering, and vacuum freeze-drying the filtrate to obtain a dry product; S3. Dissolve the dried product in 72% to 75% ethanol, add carbomer, glycerol, propylene glycol, azone, and vitamin E, and mix well to obtain a mixture. Then, add 1 to 1.2 times the mass of water of the mixture, let it stand until it swells, and adjust the pH to neutral to obtain the hair growth and nourishing gel.

3. The method for preparing the hair growth and nourishing gel according to claim 2, wherein: In S1, the solvent for heating and refluxing is water, the mass of water is 8 to 12 times the mass of the Chinese medicine mixture, the extraction temperature is 83 to 86°C, the extraction time is 1.5 to 2 hours, and the number of extractions is 2 to 3 times.

4. The method for preparing the hair growth and nourishing gel according to claim 3, wherein: The relative density of the extract is 1.05-1.

25.

5. The method for preparing the hair growth and nourishing gel according to claim 4, characterized in that: In S2, the volume fraction of the ethanol solution is 94%~95%.

6. The method for preparing the hair growth and nourishing gel according to claim 5, characterized in that: In S3, the dry product and ethanol are in an equal mass ratio.

7. The method for preparing the hair growth and nourishing gel according to claim 6, characterized in that: The pH was adjusted with triethanolamine.

8. Use of the hair growth and nourishing gel according to claim 1 in the preparation of a medicament for improving the sub-healthy state of the scalp and hair.

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