Traditional Chinese medicine composition for treating gout and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating gout and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: Feiluo flour, ginger juice, scallion juice, vinegar and oxhide gelatin. The weight ratio of the Feiluo flour to the ginger juice to the scallion juice to the vinegar to the oxhide gelatin is 2: 1: 1: 1: 1. The preparation method comprises the following steps: mixing the raw materials, heating for melting, and slightly decocting to obtain the plaster. The traditional proved recipe is optimized, the Feiluo powder, the ginger juice, the scallion juice, the vinegar and the oxhide gelatin are carefully selected, and a specific ratio and a preparation process are combined, so that the external application plaster is prepared, directly acts on an affected part, has the effects of quickly relieving pain, resisting inflammation and regulating uric acid metabolism, and achieves the effects of dispelling wind and relieving pain.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating gout and a preparation method thereof. Background Art

[0002] Gout is an inflammatory disease caused by abnormal uric acid metabolism, characterized by severe joint pain, swelling, and limited mobility. Currently, clinical treatment relies primarily on Western medications (such as colchicine and nonsteroidal anti-inflammatory drugs), but long-term use can easily cause side effects such as gastrointestinal damage and liver and kidney toxicity.

[0003] Existing traditional Chinese medicine treatments for gout mostly use oral decoctions or external application patches, but there are the following problems:

[0004] Slow onset of effect: Oral medications require metabolism and absorption, making it difficult to quickly relieve acute pain;

[0005] Complex ingredients: The compatibility of compound medicinal materials is complicated and quality control is difficult;

[0006] Strong local irritation: Some topical medications can easily cause skin allergies. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a traditional Chinese medicine composition for treating gout and a preparation method thereof.

[0008] To solve the above technical problems, the present invention provides a technical solution comprising a Chinese medicine composition for treating gout and a preparation method thereof:

[0009] A traditional Chinese medicine composition for treating gout comprises the following raw materials: feiluo noodles, ginger juice, scallion juice, vinegar and cowhide glue.

[0010] Furthermore, the weight ratio of the feiluo noodles, ginger juice, scallion juice, vinegar and cowhide glue is 2:1:1:1:1.

[0011] Furthermore, the following raw materials are included: one ounce of Feiluo noodles, five ounces of ginger juice, five ounces of green onion juice, five ounces of vinegar, and five ounces of cowhide glue.

[0012] A preparation method of a traditional Chinese medicine composition for treating gout, wherein the traditional Chinese medicine composition for treating gout is any of the traditional Chinese medicine compositions for treating gout described above, and the specific steps are: mixing the above raw materials, heating and melting, and briefly boiling to form a plaster.

[0013] Drug pharmacological analysis

[0014] Ferulic acid (extract from the dried rhizome of Stephania tetrandra of the Menispermaceae family):

[0015] Active ingredients: Tetrandrine, Fangchinoline;

[0016] Mechanism of action: Inhibits xanthine oxidase (XO) activity and reduces uric acid production; reduces the expression of inflammatory factors such as IL-1β and TNF-α by inhibiting the NF-κB pathway.

[0017] Ginger juice (extracted from the fresh rhizome of ginger, a plant of the Zingiberaceae family):

[0018] Active ingredients: Gingerols, Shogaols;

[0019] Mechanism of action: Inhibits COX-2 enzyme activity, reduces prostaglandin synthesis, and relieves pain; broad-spectrum antibacterial effect prevents secondary infection.

[0020] Onion juice (liquid extracted from the fresh stems of the scallion plant of the lily family):

[0021] Active ingredients: Sulfur compounds (such as allyl sulfide), quercetin;

[0022] Mechanism of action: Promotes local blood circulation, accelerates uric acid metabolism; acts as an antioxidant to scavenge free radicals and reduce oxidative damage to joints.

[0023] Vinegar (rice vinegar or aged vinegar):

[0024] Active ingredients: acetic acid, amino acids;

[0025] Mechanism of action: The acidic environment promotes transdermal absorption of drugs; softens tophi and relieves joint stiffness.

[0026] Cowhide glue (glue made from the skin of bovine animals):

[0027] Active ingredients: collagen, gelatin peptide;

[0028] Mechanism of action: Forms a moisturizing film, prolongs the drug's action time, and repairs damaged skin barrier.

[0029] The synergistic effect of the present invention: Feiluo noodles inhibit uric acid production, ginger juice and onion juice are anti-inflammatory and analgesic, vinegar promotes drug penetration, and cowhide glue enhances the stability of the patch. The five ingredients work together to achieve an integrated treatment of "lowering uric acid, anti-inflammation, analgesia, and repair."

[0030] The advantages of the present invention over the prior art are: the present invention optimizes the traditional prescription, selects feiluo noodles, ginger juice, scallion juice, vinegar and cowhide glue, combines a specific ratio and preparation process, and makes an external application plaster, which acts directly on the affected area, has the effects of rapid analgesia, anti-inflammation and regulating uric acid metabolism, achieves the effect of dispelling wind and relieving pain, and has very little toxic and side effects. DETAILED DESCRIPTION

[0031] Example 1, a traditional Chinese medicine composition for treating gout and a preparation method thereof, comprising the following raw materials: feiluo noodles, ginger juice, onion juice, vinegar, and cowhide glue.

[0032] The weight ratio of the feiluo noodles, ginger juice, scallion juice, vinegar and cowhide glue is 2:1:1:1:1.

[0033] The preparation method is: mix the above ingredients, heat and melt, and simmer briefly to make a plaster.

[0034] When implementing:

[0035] Grind the flour into 100 mesh fine powder;

[0036] Ginger juice and scallion juice are squeezed and filtered from fresh ginger and scallion respectively;

[0037] Mix the flour, ginger juice, scallion juice, and vinegar, heat in a 60°C water bath, and stir until it becomes a paste.

[0038] Add kraft glue, continue heating to 80°C and stirring for 30 minutes to form a uniform paste, cool to room temperature, and package and seal.

[0039] Directions:

[0040] Clean the affected skin, take 5g of ointment and spread it evenly on the non-woven patch, cover the affected area, and fix it for 6 hours before removing it;

[0041] Use once daily in the acute phase and once every other day in the chronic phase. Continuous use should be ≤ 14 days.

[0042] Invention Clinical Trial Data:

[0043] Experimental Design:

[0044] Participants: 120 patients with acute gouty arthritis (meeting the ACR 2015 classification criteria) were randomly divided into an experimental group (n=80) and a control group (n=40, using flurbiprofen gel patch);

[0045] Efficacy evaluation:

[0046] Primary endpoint: change from baseline in visual analogue scale (VAS);

[0047] Secondary endpoints: time for joint swelling to subside and changes in CRP levels.

[0048] Test results:

[0049] index Experimental group (n=80) Control group (n=40) P-value 2-hour VAS reduction value (mm) 32.1±8.3 18.4±7.1 <0.001 24-hour CRP decrease rate (%) 45.2±9.8 31.7±8.6 <0.001 Swelling subsidence time (h) 42.3±12.5 68.7±15.2 <0.001

[0050] Safety evaluation:

[0051] This drug can achieve the effect of quickly dispelling wind and relieving pain. Only 3 cases in the experimental group experienced mild skin flushing (3.75%), while 7 cases in the control group experienced gastrointestinal discomfort (17.5%). The drug effect and safety were higher than those in the control group.

[0052] Pharmacology and toxicology tests:

[0053] Acute toxicity test (oral administration in rats, the dose is 100 times the clinical dose):

[0054] During the 72-hour observation period, no death or abnormal behavior was observed, and no damage was found in the heart, liver, or kidney pathological sections.

[0055] Skin irritation test (applied to the hair removal area on the back of rabbits for 24 hours):

[0056] No erythema or edema occurred, and the irritation index was 0.0, which met the safety standards for external use preparations.

[0057] Typical Cases

[0058] Case 1:

[0059] Patient: A 48-year-old male with recurrent swelling and redness of the first metatarsophalangeal joint of the right foot for 2 years;

[0060] Medical history: blood uric acid 589μmol / L, this attack has not been relieved for 48 hours;

[0061] Treatment: 4 hours after applying the plaster, the VAS score decreased from 8 to 3, and 24 hours later, the joint circumference decreased from 12.8 cm to 10.2 cm;

[0062] Follow-up: After 5 days of continuous use, the serum uric acid level dropped to 462 μmol / L.

[0063] Case 2

[0064] Patient: A 62-year-old female with tophi formation in both knee joints;

[0065] Medical history: Abnormal liver function after long-term use of allopurinol;

[0066] Treatment: Plaster combined with low-dose colchicine. The patient can get out of bed and move around after 3 days. ALT and AST are maintained within the normal range during treatment.

[0067] The present invention and its implementation methods are described above. This description is not restrictive. If ordinary technicians in this field are inspired by it and design embodiments similar to the technical solution without creatively designing them without departing from the purpose of the invention, they should all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating gout, characterized in that The ingredients include: noodles, ginger juice, onion juice, vinegar, and cowhide glue.

2. A Chinese medicine composition for treating gout according to claim 1, characterized in that: The weight ratio of the feiluo noodles, ginger juice, scallion juice, vinegar and cowhide glue is 2:1:1:1:

1.

3. A Chinese medicine composition for treating gout according to claim 2, characterized in that: The ingredients include: one ounce of Feiluo noodles, five ounces of ginger juice, five ounces of onion juice, five ounces of vinegar, and five ounces of cowhide glue.

4. A method for preparing a Chinese medicine composition for treating gout, wherein the Chinese medicine composition for treating gout is the Chinese medicine composition for treating gout according to any one of claims 1 to 3, characterized in that: Mix the above ingredients, heat and melt, and simmer briefly to make a plaster.