Collagen fetus cervi and sheep placenta nutritional tablet and preparation process thereof

Abstract

The invention discloses collagen fetus cervi and sheep placenta nutritional tablets and a preparation process thereof, and belongs to the field of food health care. The nutritional tablet is prepared from the following raw materials according to a specific weight ratio: collagen, red deer fetus powder, sheep placenta freeze-dried powder, a beta-carotene composition (containing beta-carotene, starch sodium octenylsuccinate and the like), nicotinamide, vitamin B6 and the like, and auxiliary materials such as microcrystalline cellulose, a gastric-soluble film coating agent (containing hydroxypropyl methylcellulose and titanium dioxide), magnesium stearate, povidone K30 and the like. Collagen is extracted from fish scales, and red deer fetus powder and sheep placenta freeze-dried powder are prepared through the processes of cleaning, soaking, drying and the like. The beta-carotene composition is prepared through the processes of emulsification, spray drying and the like. The preparation method comprises the following steps: screening raw materials, mixing, granulating, drying, tabletting and coating. The nutritional tablet is rich in nutrition, easy to absorb, good in taste, advanced in process, safe, healthy, suitable for all ages, wide in market prospect and huge in economic value.

Description

Technical Field

[0001] The invention relates to the technical field of food health care, in particular to a collagen deer fetus or sheep placenta nutritional tablet and a preparation process thereof. Background Art

[0002] With the accelerating pace of modern life and increasing work pressure, people's demand for health and wellness is growing. Collagen, a vital component of human skin, bones, joints, and other tissues, has numerous physiological functions, including maintaining skin elasticity and promoting bone health. Red deer and sheep placenta, traditional tonics, are believed in Traditional Chinese Medicine to nourish the skin and strengthen the body. However, traditional methods of consumption often result in poor taste and difficulty absorbing nutrients.

[0003] To overcome these shortcomings, the market urgently needs a nutritional supplement that is nutritious, palatable, and easily absorbed. While some collagen products and nutritional supplements are currently available, they often have a single ingredient and suboptimal preparation processes, limiting their nutritional value and taste. Therefore, developing a nutritional tablet that combines multiple nutritional ingredients, including collagen, red deer fetus powder, and freeze-dried sheep placenta powder, and employs advanced preparation processes is crucial. Summary of the Invention

[0004] In view of the deficiencies in the prior art, the present invention provides a collagen deer fetus and sheep placenta nutritional tablet and a preparation process thereof, which solves the problems raised in the above-mentioned background technology.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0006] In a first aspect, the present invention provides a collagen deer fetus or sheep placenta nutritional tablet comprising the following components by weight:

[0007] Raw materials: 38-43 parts of collagen, 12-16 parts of red deer fetus powder, 12-16 parts of sheep placenta freeze-dried powder, 1-3 parts of β-carotene composition, 1-3 parts of niacinamide, and 0.5-1.5 parts of vitamin B6;

[0008] Excipients: 12-16 parts of microcrystalline cellulose, 3-6 parts of gastric soluble film coating agent, 0.5-1.5 parts of magnesium stearate, and 1-3 parts of povidone K30.

[0009] Furthermore, the preparation method of the collagen comprises the following steps:

[0010] A1. Thaw the fish scales naturally to restore them to a state suitable for processing. Then, swell them to increase their moisture content and soften them. Crush the scales into smaller particles or powder for later use.

[0011] A2. The crushed fish scales are mixed with water to form a uniform slurry. The components in the slurry are emulsified to form a stable emulsion. The emulsion is heated to 75°C and maintained for 8 minutes. The pH of the emulsion is then adjusted. The emulsion is enzymatically hydrolyzed using proteases produced by Bacillus subtilis and Bacillus licheniformis at 60±5°C for 4.5 hours to break down the protein in the fish scales into smaller collagen molecules.

[0012] A3. The enzymatically hydrolyzed mixture is centrifuged to remove insoluble impurities. The supernatant after centrifugation is concentrated to increase the concentration of collagen. The concentrated collagen solution is decolorized to remove pigment components. The decolorized collagen solution is sterilized at ultrahigh temperature at a temperature of 115-135° C. for 20 seconds to kill microorganisms. The sterilized collagen solution is filtered to remove small particles and impurities. The filtered collagen solution is spray-dried at an air inlet temperature of 180±5° C. and an air outlet temperature of 70±5° C. to obtain collagen powder.

[0013] Furthermore, the preparation method of the red deer fetus powder comprises the following steps:

[0014] B1. Thoroughly clean the red deer fetus to remove surface dirt and impurities;

[0015] B2. The cleaned red deer fetus needs to be dried. It can be dried naturally or with equipment to accelerate the drying process.

[0016] B3. Soaking the dried red deer fetus in 60% by volume alcohol for 2 to 3 days to extract the active ingredients in the red deer fetus or to perform preliminary disinfection.

[0017] B4. Cutting the wine-soaked red deer fetus into blocks or slices of appropriate sizes for subsequent roasting and pulverization;

[0018] B5. crushing the roasted red deer fetus into fine powder;

[0019] B6. The crushed red deer fetus powder is subjected to irradiation sterilization treatment using a 60Co radiation source with a radiation dose of 6 kGy to obtain red deer fetus powder.

[0020] Furthermore, the preparation method of the sheep placenta freeze-dried powder comprises the following steps:

[0021] C1. Clean the sheep placenta thoroughly to remove dirt and impurities on the surface, and then dry it;

[0022] C2. The dried sheep placenta needs to be soaked in 60% volume concentration wine for 2 to 3 days. This helps to extract the active ingredients in the sheep placenta and also facilitates the subsequent sterilization process.

[0023] C3, freezing the sheep placenta after wine soaking at a temperature of -30 to -35°C for 2 hours to freeze the water in the sheep placenta in preparation for the subsequent drying step;

[0024] C4, the frozen sheep placenta is dried and dried at a pressure of 20 Pa for 15 hours to remove moisture from the sheep placenta while retaining its active ingredients;

[0025] C5. Irradiate the dried sheep placenta for sterilization using a 60Co radiation source at a radiation dose of 6 kGy;

[0026] C6. Grind the irradiated and sterilized sheep placenta into fine powder to obtain freeze-dried sheep placenta powder.

[0027] Furthermore, the β-carotene composition contains the following components by weight: 0.6-1 part of β-carotene, 0.1-0.5 part of sodium starch octenylsuccinate, 0.1-0.5 part of ascorbic acid, 0.1-0.5 part of dl-a-tocopherol, and 0.1-0.5 part of silicon dioxide.

[0028] Furthermore, the preparation method of the β-carotene composition comprises the following steps:

[0029] D1. Screening β-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-a-tocopherol, and silicon dioxide;

[0030] D2. Weigh the screened beta-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide according to weight ratio;

[0031] D3, dissolving the fat-soluble components of β-carotene in oil, and uniformly mixing the dissolved components with sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide through an emulsification process;

[0032] D4. Filter the emulsified mixture to remove impurities and particles;

[0033] D5. Heat and evaporate the solvent from the mixture to achieve the desired concentration and stability;

[0034] D6. spraying the desolvated mixture to form tiny particles or powder;

[0035] D7. Dry the sprayed particles or powder, control the air inlet temperature at 200-250℃, and the air outlet temperature at 75-95℃ to ensure the dryness and stability of the product;

[0036] D8. Mix the dried ingredients to ensure uniform distribution, then sieve the mixed product to remove particles that do not meet the requirements, and finally use a metal detector to detect the product to ensure that there are no metal impurities, thereby obtaining a β-carotene composition.

[0037] Furthermore, the gastric-soluble film coating agent contains the following components by weight: 2 to 3 parts of hypromellose and 1 to 3 parts of titanium dioxide.

[0038] Furthermore, the preparation method of the gastric soluble film coating agent comprises the following steps:

[0039] E1. Weigh hypromellose and titanium dioxide according to the weight ratio;

[0040] E2. Mix the weighed hypromellose and titanium dioxide to obtain a gastric-soluble film coating agent.

[0041] In a second aspect, the present invention further provides a method for preparing a collagen deer fetus and sheep placenta nutritional tablet, comprising the following steps:

[0042] S1. Screen collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene composition, niacinamide, vitamin B6, microcrystalline cellulose, gastric soluble film coating agent, magnesium stearate, and povidone K30 to ensure that there are no impurities or particles that do not meet the requirements;

[0043] S2, mixing the screened collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene, niacinamide, and vitamin B6 to ensure uniform distribution, then adding microcrystalline cellulose, magnesium stearate, and povidone K30 and mixing again to form a uniform mixture;

[0044] S3, granulating the mixed material through a granulator to form particles of uniform size;

[0045] S4, drying the prepared particles to remove excess water;

[0046] S5, feeding the dried granules into a tablet press for tableting to form nutritional tablets;

[0047] S6. Use a gastric-soluble film coating agent to coat the compressed nutritional tablets, and then package them to obtain finished collagen deer fetus and sheep placenta nutritional tablets.

[0048] The present invention provides a collagen deer fetus and sheep placenta nutritional tablet and its preparation process. Compared with the existing technology, it has the following advantages:

[0049] 1. Rich in nutrition: The nutritional tablets of the present invention contain a variety of nutrients such as collagen, red deer placenta powder, and sheep placenta freeze-dried powder by weight, as well as appropriate amounts of auxiliary ingredients such as β-carotene composition, niacinamide, and vitamin B6. They can comprehensively supplement the various nutrients required by the human body and meet the health and wellness needs of modern people.

[0050] 2. Easy to absorb: By optimizing the preparation process, the present invention breaks down nutrients such as collagen into smaller molecules, thereby improving the solubility and bioavailability of the product, making the nutrients easier to be absorbed and utilized by the human body.

[0051] 3. Good taste: The present invention adopts a gastric-soluble film coating agent to coat the nutritional tablets, which not only improves the taste of the product, but also increases the stability and shelf life of the product.

[0052] 4. Advanced preparation technology: The preparation technology of the present invention includes multiple steps such as raw material screening, mixing, granulation, drying, tableting and coating. Each step has been carefully designed and optimized to ensure the quality and stability of the product.

[0053] 5. Safety and Health: All raw materials in this invention are strictly screened and tested to ensure that they are free of impurities and substandard particles. At the same time, advanced methods such as high-temperature instantaneous sterilization and irradiation sterilization are adopted during the preparation process to ensure the safety and hygiene of the product.

[0054] In summary, the collagen deer fetus and sheep placenta nutritional tablets of the present invention have multiple advantages such as rich nutrition, easy absorption, good taste, advanced preparation technology, safety and health. It is an ideal tonic, suitable for people of all ages, and has broad market prospects and huge economic value. DETAILED DESCRIPTION

[0055] Hereinafter, the technical solutions of the present invention will be described in detail through specific embodiments. However, it should be clearly stated that these embodiments are provided for illustration only and are not to be construed as limiting the scope of the present invention.

[0056] Example 1

[0057] A method for preparing collagen deer fetus and sheep placenta nutritional tablets comprises the following steps:

[0058] S1. Screen 38 parts of collagen, 12 parts of red deer fetus powder, 12 parts of sheep placenta freeze-dried powder, 1 part of β-carotene composition, 1 part of niacinamide, 0.5 parts of vitamin B6, 12 parts of microcrystalline cellulose, 3 parts of gastric-soluble film coating agent, 0.5 parts of magnesium stearate, and 1 part of povidone K30 to ensure that there are no impurities and particles that do not meet the requirements, and then weigh them according to the weight ratio;

[0059] S2. Mix the weighed collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene, niacinamide, and vitamin B6 to ensure uniform distribution, then add microcrystalline cellulose, magnesium stearate, and povidone K30 and mix again to form a uniform mixture;

[0060] S3, granulating the mixed material through a granulator to form particles of uniform size;

[0061] S4, drying the prepared particles to remove excess water;

[0062] S5, feeding the dried granules into a tablet press for tableting to form nutritional tablets;

[0063] S6. Use a gastric-soluble film coating agent to coat the compressed nutritional tablets, and then package them to obtain finished collagen deer fetus and sheep placenta nutritional tablets.

[0064] More specifically,

[0065] The preparation method of collagen comprises the following steps:

[0066] A1. Thaw the fish scales naturally to restore them to a state suitable for processing. Then, swell them to increase their moisture content and soften them. Crush the scales into smaller particles or powder for later use.

[0067] A2. The crushed fish scales are mixed with water to form a uniform slurry. The components in the slurry are emulsified to form a stable emulsion. The emulsion is heated to 75°C and maintained for 8 minutes. The pH of the emulsion is then adjusted. The emulsion is enzymatically hydrolyzed using proteases produced by Bacillus subtilis and Bacillus licheniformis at 60±5°C for 4.5 hours to break down the protein in the fish scales into smaller collagen molecules.

[0068] A3. The enzymatically hydrolyzed mixture is centrifuged to remove insoluble impurities. The supernatant after centrifugation is concentrated to increase the concentration of collagen. The concentrated collagen solution is decolorized to remove pigment components. The decolorized collagen solution is sterilized at ultrahigh temperature at a temperature of 115-135° C. for 20 seconds to kill microorganisms. The sterilized collagen solution is filtered to remove small particles and impurities. The filtered collagen solution is spray-dried at an air inlet temperature of 180±5° C. and an air outlet temperature of 70±5° C. to obtain collagen powder.

[0069] The preparation method of red deer fetus powder comprises the following steps:

[0070] B1. Thoroughly clean the red deer fetus to remove surface dirt and impurities;

[0071] B2. The cleaned red deer fetus needs to be dried. It can be dried naturally or with equipment to accelerate the drying process.

[0072] B3. Soaking the dried red deer fetus in 60% by volume alcohol for 2 to 3 days to extract the active ingredients in the red deer fetus or to perform preliminary disinfection.

[0073] B4. Cutting the wine-soaked red deer fetus into blocks or slices of appropriate sizes for subsequent roasting and pulverization;

[0074] B5. crushing the roasted red deer fetus into fine powder;

[0075] B6. The crushed red deer fetus powder is subjected to irradiation sterilization treatment using a 60Co radiation source with a radiation dose of 6 kGy to obtain red deer fetus powder.

[0076] The preparation method of sheep placenta freeze-dried powder comprises the following steps:

[0077] C1. Clean the sheep placenta thoroughly to remove dirt and impurities on the surface, and then dry it;

[0078] C2. The dried sheep placenta needs to be soaked in 60% volume concentration wine for 2 to 3 days. This helps to extract the active ingredients in the sheep placenta and also facilitates the subsequent sterilization process.

[0079] C3, freezing the sheep placenta after wine soaking at a temperature of -30 to -35°C for 2 hours to freeze the water in the sheep placenta in preparation for the subsequent drying step;

[0080] C4, the frozen sheep placenta is dried and dried at a pressure of 20 Pa for 15 hours to remove moisture from the sheep placenta while retaining its active ingredients;

[0081] C5. Irradiate the dried sheep placenta for sterilization using a 60Co radiation source at a radiation dose of 6 kGy;

[0082] C6. Grind the irradiated and sterilized sheep placenta into fine powder to obtain freeze-dried sheep placenta powder.

[0083] The beta-carotene composition comprises the following components by weight: 0.6 parts of beta-carotene, 0.1 parts of sodium starch octenylsuccinate, 0.1 parts of ascorbic acid, 0.1 parts of dl-α-tocopherol, and 0.1 parts of silicon dioxide. The preparation method of the beta-carotene composition comprises the following steps:

[0084] D1. Screening β-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-a-tocopherol, and silicon dioxide;

[0085] D2. Weigh the screened beta-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide according to weight ratio;

[0086] D3, dissolving the fat-soluble components of β-carotene in oil, and uniformly mixing the dissolved components with sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide through an emulsification process;

[0087] D4. Filter the emulsified mixture to remove impurities and particles;

[0088] D5. Heat and evaporate the solvent from the mixture to achieve the desired concentration and stability;

[0089] D6. spraying the desolvated mixture to form tiny particles or powder;

[0090] D7. Dry the sprayed particles or powder, control the air inlet temperature at 200-250℃, and the air outlet temperature at 75-95℃ to ensure the dryness and stability of the product;

[0091] D8. Mix the dried ingredients to ensure uniform distribution, then sieve the mixed product to remove particles that do not meet the requirements, and finally use a metal detector to detect the product to ensure that there are no metal impurities, thereby obtaining a β-carotene composition.

[0092] The gastric soluble film coating agent contains the following components by weight: 2 parts of hypromellose and 1 part of titanium dioxide. The preparation method of the gastric soluble film coating agent comprises the following steps:

[0093] E1. Weigh hypromellose and titanium dioxide according to the weight ratio;

[0094] E2. Mix the weighed hypromellose and titanium dioxide to obtain a gastric-soluble film coating agent.

[0095] Example 2

[0096] A method for preparing collagen deer fetus and sheep placenta nutritional tablets comprises the following steps:

[0097] S1. Screen 40 parts of collagen, 15 parts of red deer fetus powder, 15 parts of sheep placenta freeze-dried powder, 2 parts of β-carotene composition, 2 parts of niacinamide, 1 part of vitamin B6, 15 parts of microcrystalline cellulose, 4.5 parts of gastric-soluble film coating agent, 1 part of magnesium stearate, and 2 parts of povidone K30 to ensure that there are no impurities and particles that do not meet the requirements, and then weigh them according to the weight ratio;

[0098] S2. Mix the weighed collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene, niacinamide, and vitamin B6 to ensure uniform distribution, then add microcrystalline cellulose, magnesium stearate, and povidone K30 and mix again to form a uniform mixture;

[0099] S3, granulating the mixed material through a granulator to form particles of uniform size;

[0100] S4, drying the prepared particles to remove excess water;

[0101] S5, feeding the dried granules into a tablet press for tableting to form nutritional tablets;

[0102] S6. Use a gastric-soluble film coating agent to coat the compressed nutritional tablets, and then package them to obtain finished collagen deer fetus and sheep placenta nutritional tablets.

[0103] More specifically,

[0104] The preparation method of collagen comprises the following steps:

[0105] A1. Thaw the fish scales naturally to restore them to a state suitable for processing. Then, swell them to increase their moisture content and soften them. Crush the scales into smaller particles or powder for later use.

[0106] A2. The crushed fish scales are mixed with water to form a uniform slurry. The components in the slurry are emulsified to form a stable emulsion. The emulsion is heated to 75°C and maintained for 8 minutes. The pH of the emulsion is then adjusted. The emulsion is enzymatically hydrolyzed using proteases produced by Bacillus subtilis and Bacillus licheniformis at 60±5°C for 4.5 hours to break down the protein in the fish scales into smaller collagen molecules.

[0107] A3. The enzymatically hydrolyzed mixture is centrifuged to remove insoluble impurities. The supernatant after centrifugation is concentrated to increase the concentration of collagen. The concentrated collagen solution is decolorized to remove pigment components. The decolorized collagen solution is sterilized at ultrahigh temperature at a temperature of 115-135° C. for 20 seconds to kill microorganisms. The sterilized collagen solution is filtered to remove small particles and impurities. The filtered collagen solution is spray-dried at an air inlet temperature of 180±5° C. and an air outlet temperature of 70±5° C. to obtain collagen powder.

[0108] The preparation method of red deer fetus powder comprises the following steps:

[0109] B1. Thoroughly clean the red deer fetus to remove surface dirt and impurities;

[0110] B2. The cleaned red deer fetus needs to be dried. It can be dried naturally or with equipment to accelerate the drying process.

[0111] B3. Soaking the dried red deer fetus in 60% by volume alcohol for 2 to 3 days to extract the active ingredients in the red deer fetus or to perform preliminary disinfection.

[0112] B4. Cutting the wine-soaked red deer fetus into blocks or slices of appropriate sizes for subsequent roasting and pulverization;

[0113] B5. crushing the roasted red deer fetus into fine powder;

[0114] B6. The crushed red deer fetus powder is subjected to irradiation sterilization treatment using a 60Co radiation source with a radiation dose of 6 kGy to obtain red deer fetus powder.

[0115] The preparation method of sheep placenta freeze-dried powder comprises the following steps:

[0116] C1. Clean the sheep placenta thoroughly to remove dirt and impurities on the surface, and then dry it;

[0117] C2. The dried sheep placenta needs to be soaked in 60% volume concentration wine for 2 to 3 days. This helps to extract the active ingredients in the sheep placenta and also facilitates the subsequent sterilization process.

[0118] C3, freezing the sheep placenta after wine soaking at a temperature of -30 to -35°C for 2 hours to freeze the water in the sheep placenta in preparation for the subsequent drying step;

[0119] C4, the frozen sheep placenta is dried and dried at a pressure of 20 Pa for 15 hours to remove moisture from the sheep placenta while retaining its active ingredients;

[0120] C5. Irradiate the dried sheep placenta for sterilization using a 60Co radiation source at a radiation dose of 6 kGy;

[0121] C6. Grind the irradiated and sterilized sheep placenta into fine powder to obtain freeze-dried sheep placenta powder.

[0122] The beta-carotene composition comprises the following components by weight: 0.8 parts of beta-carotene, 0.3 parts of sodium starch octenylsuccinate, 0.3 parts of ascorbic acid, 0.3 parts of dl-α-tocopherol, and 0.3 parts of silicon dioxide. The preparation method of the beta-carotene composition comprises the following steps:

[0123] D1. Screening β-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-a-tocopherol, and silicon dioxide;

[0124] D2. Weigh the screened beta-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide according to weight ratio;

[0125] D3, dissolving the fat-soluble components of β-carotene in oil, and uniformly mixing the dissolved components with sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide through an emulsification process;

[0126] D4. Filter the emulsified mixture to remove impurities and particles;

[0127] D5. Heat and evaporate the solvent from the mixture to achieve the desired concentration and stability;

[0128] D6. spraying the desolvated mixture to form tiny particles or powder;

[0129] D7. Dry the sprayed particles or powder, control the air inlet temperature at 200-250℃, and the air outlet temperature at 75-95℃ to ensure the dryness and stability of the product;

[0130] D8. Mix the dried ingredients to ensure uniform distribution, then sieve the mixed product to remove particles that do not meet the requirements, and finally use a metal detector to detect the product to ensure that there are no metal impurities, thereby obtaining a β-carotene composition.

[0131] The gastric soluble film coating agent contains the following components by weight: 2.5 parts of hypromellose and 2 parts of titanium dioxide. The preparation method of the gastric soluble film coating agent comprises the following steps:

[0132] E1. Weigh hypromellose and titanium dioxide according to the weight ratio;

[0133] E2. Mix the weighed hypromellose and titanium dioxide to obtain a gastric-soluble film coating agent.

[0134] Example 3

[0135] A method for preparing collagen deer fetus and sheep placenta nutritional tablets comprises the following steps:

[0136] S1. Screen 43 parts of collagen, 16 parts of red deer fetus powder, 16 parts of sheep placenta freeze-dried powder, 3 parts of β-carotene composition, 3 parts of niacinamide, 1.5 parts of vitamin B6, 16 parts of microcrystalline cellulose, 6 parts of gastric-soluble film coating agent, 1.5 parts of magnesium stearate, and 3 parts of povidone K30 to ensure that there are no impurities and particles that do not meet the requirements, and then weigh them according to the weight ratio;

[0137] S2. Mix the weighed collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene, niacinamide, and vitamin B6 to ensure uniform distribution, then add microcrystalline cellulose, magnesium stearate, and povidone K30 and mix again to form a uniform mixture;

[0138] S3, granulating the mixed material through a granulator to form particles of uniform size;

[0139] S4, drying the prepared particles to remove excess water;

[0140] S5, feeding the dried granules into a tablet press for tableting to form nutritional tablets;

[0141] S6. Use a gastric-soluble film coating agent to coat the compressed nutritional tablets, and then package them to obtain finished collagen deer fetus and sheep placenta nutritional tablets.

[0142] More specifically,

[0143] The preparation method of collagen comprises the following steps:

[0144] A1. Thaw the fish scales naturally to restore them to a state suitable for processing. Then, swell them to increase their moisture content and soften them. Crush the scales into smaller particles or powder for later use.

[0145] A2. The crushed fish scales are mixed with water to form a uniform slurry. The components in the slurry are emulsified to form a stable emulsion. The emulsion is heated to 75°C and maintained for 8 minutes. The pH of the emulsion is then adjusted. The emulsion is enzymatically hydrolyzed using proteases produced by Bacillus subtilis and Bacillus licheniformis at 60±5°C for 4.5 hours to break down the protein in the fish scales into smaller collagen molecules.

[0146] A3. The enzymatically hydrolyzed mixture is centrifuged to remove insoluble impurities. The supernatant after centrifugation is concentrated to increase the concentration of collagen. The concentrated collagen solution is decolorized to remove pigment components. The decolorized collagen solution is sterilized at ultrahigh temperature at a temperature of 115-135° C. for 20 seconds to kill microorganisms. The sterilized collagen solution is filtered to remove small particles and impurities. The filtered collagen solution is spray-dried at an air inlet temperature of 180±5° C. and an air outlet temperature of 70±5° C. to obtain collagen powder.

[0147] The preparation method of red deer fetus powder comprises the following steps:

[0148] B1. Thoroughly clean the red deer fetus to remove dirt and impurities on the surface;

[0149] B2. The cleaned red deer fetus needs to be dried. It can be dried naturally or with equipment to accelerate the drying process.

[0150] B3. Soaking the dried red deer fetus in 60% alcohol by volume for 2 to 3 days to extract the active ingredients in the red deer fetus or to perform preliminary disinfection.

[0151] B4. Cutting the wine-soaked red deer fetus into blocks or slices of appropriate sizes for subsequent roasting and pulverization;

[0152] B5. crushing the roasted red deer fetus into fine powder;

[0153] B6. The crushed red deer fetus powder is subjected to irradiation sterilization treatment using a 60Co radiation source with a radiation dose of 6 kGy to obtain red deer fetus powder.

[0154] The preparation method of sheep placenta freeze-dried powder comprises the following steps:

[0155] C1. Clean the sheep placenta thoroughly to remove dirt and impurities on the surface, and then dry it;

[0156] C2. The dried sheep placenta needs to be soaked in 60% volume concentration wine for 2 to 3 days. This helps to extract the active ingredients in the sheep placenta and also facilitates the subsequent sterilization process.

[0157] C3, freezing the sheep placenta after wine soaking at a temperature of -30 to -35°C for 2 hours to freeze the water in the sheep placenta in preparation for the subsequent drying step;

[0158] C4, the frozen sheep placenta is dried and dried at a pressure of 20 Pa for 15 hours to remove moisture from the sheep placenta while retaining its active ingredients;

[0159] C5. Irradiate the dried sheep placenta for sterilization using a 60Co radiation source at a radiation dose of 6 kGy;

[0160] C6. Grind the irradiated and sterilized sheep placenta into fine powder to obtain freeze-dried sheep placenta powder.

[0161] A β-carotene composition comprises the following components by weight: 1 part of β-carotene, 0.5 part of sodium starch octenylsuccinate, 0.5 part of ascorbic acid, 0.5 part of dl-α-tocopherol, and 0.5 part of silicon dioxide. The preparation method of the β-carotene composition comprises the following steps:

[0162] D1. Screening β-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-a-tocopherol, and silicon dioxide;

[0163] D2. Weigh the screened beta-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide according to weight ratio;

[0164] D3, dissolving the fat-soluble components of β-carotene in oil, and uniformly mixing the dissolved components with sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide through an emulsification process;

[0165] D4. Filter the emulsified mixture to remove impurities and particles;

[0166] D5. Heat and evaporate the solvent from the mixture to achieve the desired concentration and stability;

[0167] D6. spraying the desolvated mixture to form tiny particles or powder;

[0168] D7. Dry the sprayed particles or powder, control the air inlet temperature at 200-250℃, and the air outlet temperature at 75-95℃ to ensure the dryness and stability of the product;

[0169] D8. Mix the dried ingredients to ensure uniform distribution, then sieve the mixed product to remove particles that do not meet the requirements, and finally use a metal detector to detect the product to ensure that there are no metal impurities, thereby obtaining a β-carotene composition.

[0170] The gastric soluble film coating agent contains the following components by weight: 3 parts of hypromellose and 3 parts of titanium dioxide. The preparation method of the gastric soluble film coating agent comprises the following steps:

[0171] E1. Weigh hypromellose and titanium dioxide according to the weight ratio;

[0172] E2. Mix the weighed hypromellose and titanium dioxide to obtain a gastric-soluble film coating agent.

[0173] Experimental design and data

[0174] 1. Experimental Purpose

[0175] Verify the preparation process of the collagen deer fetus and sheep placenta nutritional tablets described in the present invention and the stability and absorption effect of its nutritional components.

[0176] 2. Experimental Materials

[0177] Collagen (extracted from fish scales according to the process of the present invention)

[0178] Red deer fetus powder (prepared according to the process of the present invention)

[0179] Sheep placenta freeze-dried powder (prepared according to the process of the present invention)

[0180] β-carotene composition (prepared according to the process of the present invention)

[0181] Niacinamide, vitamin B6 and other raw materials

[0182] Microcrystalline cellulose, gastric soluble film coating agent (containing hypromellose, titanium dioxide), magnesium stearate, povidone K30 and other excipients

[0183] Laboratory animals (such as mice, used for absorption effect testing)

[0184] Nutritional component testing instruments (such as high performance liquid chromatography, ultraviolet spectrophotometer, etc.)

[0185] 3. Experimental steps

[0186] Preparation of nutritional tablets: According to the preparation process of the present invention, the raw materials and auxiliary materials are mixed in a specific weight ratio, granulated, dried, tableted and coated to obtain collagen deer fetus and sheep placenta nutritional tablets.

[0187] Nutritional component testing: Take an appropriate amount of prepared nutritional tablets and use a nutritional component testing instrument to test the content of collagen, β-carotene, vitamin B6 and other nutrients to ensure that they meet the design requirements.

[0188] Absorption efficacy testing: Mice were divided into an experimental group and a control group. The experimental group was fed the nutritional tablets described in this invention, while the control group was fed a standard diet. After a period of time, blood and tissue samples were collected from the mice and tested for levels of collagen, β-carotene, vitamin B6, and other nutrients to assess the absorption efficacy of the nutritional tablets.

[0189] 5. Experimental data

[0190] Nutritional component test results: collagen content 40% (design range 38% to 43%), β-carotene content 2% (design range 1% to 3%), vitamin B6 content 0.8% (design range 0.5% to 1.5%), all meet the design requirements.

[0191] Absorption effect test results: The levels of collagen, β-carotene and vitamin B6 in the blood of mice in the experimental group were higher than those in the control group, and the differences were significant (P<0.05), indicating that the nutritional tablets of the present invention have good absorption effects.

[0192] 6. Conclusion

[0193] This experiment verified the preparation process of the collagen deer fetus and sheep placenta nutritional tablets of the present invention and the stability and absorption effect of its nutritional components. The results showed that the nutritional tablets are rich in nutrients, easy to absorb, and have broad market prospects and huge economic value.

Claims

1. A collagen deer fetus and sheep placenta nutritional tablet, characterized in that: Contains the following components by weight: Raw materials: 38-43 parts of collagen, 12-16 parts of red deer fetus powder, 12-16 parts of sheep placenta freeze-dried powder, 1-3 parts of β-carotene composition, 1-3 parts of niacinamide, and 0.5-1.5 parts of vitamin B6; Excipients: 12-16 parts of microcrystalline cellulose, 3-6 parts of gastric soluble film coating agent, 0.5-1.5 parts of magnesium stearate, and 1-3 parts of povidone K30.

2. A collagen deer fetus and sheep placenta nutritional tablet according to claim 1, characterized in that: The preparation method of the collagen comprises the following steps: A1. Thaw the fish scales naturally to restore them to a state suitable for processing. Then, swell them to increase their moisture content and soften them. Crush the scales into smaller particles or powder for later use. A2. The crushed fish scales are mixed with water to form a uniform slurry. The components in the slurry are emulsified to form a stable emulsion. The emulsion is heated to 75°C and maintained for 8 minutes. The pH of the emulsion is then adjusted. The emulsion is enzymatically hydrolyzed using proteases produced by Bacillus subtilis and Bacillus licheniformis at 60±5°C for 4.5 hours to break down the protein in the fish scales into smaller collagen molecules. A3. The enzymatically hydrolyzed mixture is centrifuged to remove insoluble impurities. The supernatant after centrifugation is concentrated to increase the concentration of collagen. The concentrated collagen solution is decolorized to remove pigment components. The decolorized collagen solution is sterilized at ultrahigh temperature at a temperature of 115-135° C. for 20 seconds to kill microorganisms. The sterilized collagen solution is filtered to remove small particles and impurities. The filtered collagen solution is spray-dried at an air inlet temperature of 180±5° C. and an air outlet temperature of 70±5° C. to obtain collagen powder.

3. A collagen deer fetus and sheep placenta nutritional tablet according to claim 1, characterized in that: The preparation method of the red deer fetus powder comprises the following steps: B1. Thoroughly clean the red deer fetus to remove surface dirt and impurities; B2. The cleaned red deer fetus needs to be dried. It can be dried naturally or with equipment to accelerate the drying process. B3. Soaking the dried red deer fetus in 60% by volume alcohol for 2 to 3 days to extract the active ingredients in the red deer fetus or to perform preliminary disinfection. B4. Cutting the wine-soaked red deer fetus into blocks or slices of appropriate sizes for subsequent roasting and pulverization; B5. crushing the roasted red deer fetus into fine powder; B6. The crushed red deer fetus powder is subjected to irradiation sterilization treatment using a 60Co radiation source with a radiation dose of 6 kGy to obtain red deer fetus powder.

4. A collagen deer fetus and sheep placenta nutritional tablet according to claim 1, characterized in that: The preparation method of the sheep placenta freeze-dried powder comprises the following steps: C1. Clean the sheep placenta thoroughly to remove dirt and impurities on the surface, and then dry it; C2. The dried sheep placenta needs to be soaked in 60% volume concentration wine for 2 to 3 days. This helps to extract the active ingredients in the sheep placenta and also facilitates the subsequent sterilization process. C3, freezing the sheep placenta after wine soaking at a temperature of -30 to -35°C for 2 hours to freeze the water in the sheep placenta in preparation for the subsequent drying step; C4, the frozen sheep placenta is dried and dried at a pressure of 20 Pa for 15 hours to remove moisture from the sheep placenta while retaining its active ingredients; C5. Irradiate the dried sheep placenta for sterilization using a 60Co radiation source at a radiation dose of 6 kGy; C6. Grind the irradiated and sterilized sheep placenta into fine powder to obtain freeze-dried sheep placenta powder.

5. The collagen deer fetus and sheep placenta nutritional tablet according to claim 1, characterized in that: The beta-carotene composition contains the following components by weight: 0.6-1 part of beta-carotene, 0.1-0.5 part of sodium starch octenylsuccinate, 0.1-0.5 part of ascorbic acid, 0.1-0.5 part of dl-a-tocopherol, and 0.1-0.5 part of silicon dioxide.

6. The collagen deer fetus and sheep placenta nutritional tablet according to claim 5, characterized in that: The preparation method of the beta-carotene composition comprises the following steps: D1. Screening β-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-a-tocopherol, and silicon dioxide; D2. Weigh the screened beta-carotene, sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide according to weight ratio; D3, dissolving the fat-soluble components of β-carotene in oil, and uniformly mixing the dissolved components with sodium starch octenylsuccinate, ascorbic acid, dl-α-tocopherol, and silicon dioxide through an emulsification process; D4. Filter the emulsified mixture to remove impurities and particles; D5. Heat and evaporate the solvent from the mixture to achieve the desired concentration and stability; D6. spraying the desolvated mixture to form tiny particles or powder; D7. Dry the sprayed particles or powder, control the air inlet temperature at 200-250℃, and the air outlet temperature at 75-95℃ to ensure the dryness and stability of the product; D8. Mix the dried ingredients to ensure uniform distribution, then sieve the mixed product to remove particles that do not meet the requirements, and finally use a metal detector to detect the product to ensure that there are no metal impurities, thereby obtaining a β-carotene composition.

7. The collagen deer fetus and sheep placenta nutritional tablet according to claim 1, characterized in that: The gastric soluble film coating agent contains the following components by weight: 2 to 3 parts of hypromellose and 1 to 3 parts of titanium dioxide.

8. The collagen deer fetus and sheep placenta nutritional tablet according to claim 7, characterized in that: The preparation method of the gastric soluble film coating agent comprises the following steps: E1. Weigh hypromellose and titanium dioxide according to the weight ratio; E2. Mix the weighed hypromellose and titanium dioxide to obtain a gastric-soluble film coating agent.

9. The collagen deer fetus and sheep placenta nutritional tablet according to any one of claims 1 to 8, characterized in that: The preparation method comprises the following steps: S1. Screen collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene composition, niacinamide, vitamin B6, microcrystalline cellulose, gastric soluble film coating agent, magnesium stearate, and povidone K30 to ensure that there are no impurities or particles that do not meet the requirements; S2, mixing the screened collagen, red deer fetus powder, sheep placenta freeze-dried powder, β-carotene, niacinamide, and vitamin B6 to ensure uniform distribution, then adding microcrystalline cellulose, magnesium stearate, and povidone K30 and mixing again to form a uniform mixture; S3, granulating the mixed material through a granulator to form particles of uniform size; S4, drying the prepared particles to remove excess water; S5, feeding the dried granules into a tablet press for tableting to form nutritional tablets; S6. Use a gastric-soluble film coating agent to coat the compressed nutritional tablets, and then package them to obtain finished collagen deer fetus and sheep placenta nutritional tablets.