Anti-aging mask composition containing supramolecular rhizoma polygonati extract and preparation method of anti-aging mask composition

Abstract

The invention discloses an anti-aging mask composition containing a supramolecular rhizoma polygonati extract and a preparation method of the anti-aging mask composition, and belongs to the technical field of cosmetics. The mask composition is prepared from the following components in parts by mass: 0.5 to 5.0 parts of rhizoma polygonati extract, 0.5 to 5.0 parts of sophocarpidine oxoglutaric acid supramolecular NaDES, 0.1 to 1.0 part of acetyl hexapeptide-8, 0.05 to 0.1 part of conopeptide, 8 to 16 parts of a moisturizing agent, 0.01 to 0.5 part of a preservative, 2 to 5 parts of a thickening agent and 40 to 90 parts of water. The supramolecular NaDES is prepared by reacting sophocarpidine and oxoglutaric acid in a molar ratio of 1: (0.2-5) at 50-80 DEG C for 3-12 hours, and the stability and transdermal absorption efficiency of active ingredients are remarkably improved. The preparation method comprises the steps of step-by-step mixing, homogenizing and aging, so that the synergistic interaction of the components is ensured. Experiments show that after the mask is used for 6 weeks, the wrinkle reduction rate reaches 61.68%-67.37%, and compared with a control group, the wrinkle reduction rate is remarkably improved. Through the synergistic effect of the supramolecular carrier and the polypeptide component, the technical problems that a traditional anti-aging mask is poor in transdermal absorption and active components are easy to degrade are solved, and the anti-aging mask has a good market application prospect.

Description

Technical Field

[0001] The present invention belongs to the field of cosmetics technology and specifically relates to an anti-aging facial mask composition containing a supramolecular polygonatum extract and a preparation method thereof. The composition combines polygonatum extract with a specific supramolecular natural deep eutectic solvent (NaDES) to synergize the active polypeptide ingredients, significantly enhancing anti-aging efficacy and being suitable for facial skin care. Background Art

[0002] As consumer demand for anti-aging skincare grows, facial masks have become a hot topic in the market due to their effective topical care capabilities. Traditional anti-aging facial masks often rely on single active ingredients (such as vitamin C and retinol) or plant extracts (such as ginseng and Centella asiatica), but they have the following problems:

[0003] Low transdermal absorption efficiency: Most active ingredients have difficulty penetrating the stratum corneum due to their large molecular weight or polarity limitations, resulting in limited actual effects;

[0004] Insufficient stability: Some antioxidant ingredients (such as polyphenols) are easily degraded by light, heat or oxidation, affecting the shelf life of the product;

[0005] Lack of synergistic effect: Existing formulas often simply stack ingredients, lacking a synergistic enhancement system targeting the mechanisms of skin aging. For example, Chinese patent publication number CN110507560A proposes a facial mask containing polygonatum polysaccharide, which, while having a certain moisturizing effect, does not address the problem of poor transdermal absorption of polygonatum extract. Meanwhile, publication number CN114533597B discloses a supramolecular liposome essence with whitening, anti-aging, and antiviral properties, and its preparation method. The supramolecular liposome essence includes the following components: whitening and anti-aging active ingredients, soybean lecithin, cholesterol, tocopherol, 1,3-butylene glycol, polysorbate 80, phenoxyethanol, dipropylene glycol, glycerin, matrine coconut oil, ferulic acid, hyaluronic acid, disodium EDTA, and deionized water, but does not involve the synergistic anti-aging application of polygonatum extract and polypeptides.

[0006] Based on this, there is an urgent need to develop a new anti-aging mask composition that uses supramolecular technology to enhance the stability and bioavailability of active ingredients and optimize the synergistic mechanism of multiple components to solve the problems of insignificant anti-aging effects and poor ingredient permeability in existing technologies. Summary of the Invention

[0007] In response to the existing technical problems, the purpose of the present invention is to provide an anti-aging facial mask composition containing supramolecular Polygonatum sibiricum extract and a preparation method thereof. Through the synergistic effect of the supramolecular carrier and the polypeptide component, the technical problems of poor transdermal absorption and easy degradation of active ingredients in traditional anti-aging facial masks are solved.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] An anti-aging facial mask composition containing a supramolecular polygonatum extract comprises the following components in parts by mass:

[0010] Polygonatum sibiricum extract: 0.5-5.0 parts;

[0011] Supramolecular NaDES: 0.5-5.0 parts, wherein the supramolecular NaDES is prepared by reacting matrine with oxoglutaric acid in a molar ratio of 1:0.2-5;

[0012] Acetyl hexapeptide-8: 0.1-1.0 parts;

[0013] Conopeptide: 0.05-0.1 parts;

[0014] Moisturizer: 8-16 parts;

[0015] Preservatives: 0.01-0.5 parts;

[0016] Thickener: 2-5 parts;

[0017] Water: 40-90 parts.

[0018] Preferably, the supramolecular NaDES is prepared by the following steps: mixing matrine and oxoglutaric acid in the molar ratio, stirring and heating at 50-80° C. for 3-12 hours to obtain a viscous liquid.

[0019] Preferably, the anti-aging mask composition further comprises:

[0020] pH regulator: 0-1 part, one or more selected from L-arginine, citric acid, tartaric acid, and lactic acid;

[0021] Chelating agent: 0-0.8 parts, which is disodium EDTA.

[0022] Preferably, the moisturizing agent is selected from at least one of glycerin, 1,3-butylene glycol, sodium hyaluronate, trehalose, and betaine.

[0023] Preferably, the preservative is selected from at least one of phenoxyethanol, chlorphenesin, and caprylhydroxamic acid.

[0024] Preferably, the thickener is a combination of carbomer and xanthan gum, and the mass ratio of carbomer to xanthan gum is 1:0.5-2.

[0025] The present invention also provides a method for preparing an anti-aging facial mask composition containing a supramolecular Polygonatum sibiricum extract, comprising the following steps:

[0026] (1) Mixing a polygonatum extract, supramolecular NaDES, a pH adjuster, and water, and stirring at 50-80° C. for 25-40 minutes to obtain a mixture A;

[0027] (2) mixing the chelating agent, moisturizing agent, and preservative, and stirring at the same temperature for 25 to 40 minutes to obtain a mixture B;

[0028] (3) Homogenize mixture A and mixture B for 15 to 30 seconds, cool to 20 to 40°C, age at room temperature for 2 hours, and then fill.

[0029] Preferably, the pressure of the homogenization treatment is 10-50 MPa, and the mixing temperature of the mixture A and the mixture B is 50-80°C.

[0030] Due to the adoption of the above solution, the beneficial effects of the present invention are as follows:

[0031] 1. Highly effective anti-aging performance:

[0032] Through the synergistic effect of Polygonatum sibiricum extract and matrine oxoglutaric acid supramolecular NaDES, the transdermal absorption efficiency and bioavailability of the active ingredients are significantly improved. Combined with the polypeptide-targeted anti-wrinkle mechanism of acetyl hexapeptide-8 and cono peptide, experimental data show that after 6 weeks of continuous use, the facial wrinkle reduction rate reaches 61.68% to 67.37%, which is a significant improvement compared to traditional facial masks.

[0033] 2. Enhanced ingredient stability:

[0034] The introduction of supramolecular NaDES effectively encapsulates the active ingredients in the polygonatum extract (such as polygonatum polysaccharides, saponins, etc.), preventing them from degradation due to light, heat or oxidation during storage or use. Experiments have shown that the active ingredient retention rate of the composition in the accelerated stability test at 40°C is ≥95%.

[0035] 3. Formula synergy optimization:

[0036] The proportion of each component is strictly limited (such as 0.5-5.0 parts of polygonatum extract and 0.5-5.0 parts of supramolecular NaDES), which not only avoids the problem of sticky or irritating skin caused by excessive addition, but also ensures the synergistic enhancement of the anti-aging active system (polygonatum + polypeptide + supramolecular carrier).

[0037] 4. The preparation process is efficient and controllable:

[0038] The combination of step-by-step mixing (mixture A / B), homogenization (10-50 MPa pressure) and aging processes ensures that the active ingredients are evenly dispersed and free of aggregation, with performance differences between product batches ≤3%, while shortening the production cycle to less than 3 hours.

[0039] 5. Improved safety and skin feel:

[0040] The preferred excipient system (such as glycerin / sodium hyaluronate for moisturizing, phenoxyethanol for preservatives, and carbomer / xanthan gum for thickening) not only ensures product stability, but is also proven to be non-irritating (sensitization rate <0.1%) through human skin patch tests, and has a refreshing texture that is easily absorbed. User satisfaction surveys show a skin feel score of 4.8 / 5.0. DETAILED DESCRIPTION

[0041] The technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments of the present invention. Obviously, the embodiments described are part of the embodiments of the present invention, not all of them. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0042] Example 1

[0043] Formula of the anti-aging mask composition containing supramolecular polygonatum extract (parts by mass): 0.5 parts of polygonatum extract, 5.0 parts of matrine oxoglutarate supramolecular NaDES (molar ratio 1:2, prepared by reaction at 60°C for 8 hours), 0.1 parts of acetyl hexapeptide-8, 0.05 parts of cono peptide, 3.0 parts of glycerin, 0.2 parts of sodium hyaluronate, 5.0 parts of 1,3-butylene glycol, 1.5 parts of carbomer, 1.2 parts of xanthan gum, 0.2 parts of phenoxyethanol, 0.15 parts of methylparaben, 0.1 parts of L-arginine, and 82.9 parts of water.

[0044] The preparation method is as follows:

[0045] (1) Mix the polygonatum extract, supramolecular NaDES, L-arginine and water, and stir at 60°C for 30 minutes to obtain mixture A;

[0046] (2) Glycerin, 1,3-butylene glycol, sodium hyaluronate, phenoxyethanol, and methylparaben were mixed and stirred at 60° C. for 30 minutes to obtain a mixture B;

[0047] (3) Mixtures A and B were homogenized (30 MPa, 20 seconds), cooled to 30°C, aged at room temperature for 2 hours, and then filled.

[0048] Example 2-5:

[0049] The formula is shown in Table 1. The preparation method is the same as that in Example 1, except that the amounts of the polygonatum extract and supramolecular NaDES are adjusted (see Table 1 for details).

[0050] Table 1

[0051]

[0052] The performance test results are shown in Table 2

[0053] Test method:

[0054] Anti-aging effect: Volunteers aged 35 to 55 (20 people per group) used the product for 6 consecutive weeks, and the wrinkle reduction rate was measured by VISIA analyzer;

[0055] Stability: Accelerated test at 40°C for 6 months to detect the retention rate of active ingredients;

[0056] Skin feel score: 30 subjects gave blind scores (1 to 5 points, 5 being the best).

[0057] The test results are shown in Table 2.

[0058] Table 2

[0059] Group Wrinkle reduction rate in week 3 Wrinkle reduction rate in week 6 Stability (activity retention) Skin feel score Example 1 47.35 63.19 96.2 4.5 Example 2 48.12 65.47 95.8 4.6 Example 3 50.36 67.37 97.5 4.8 Example 4 47.69 61.68 94.3 4.4 Example 5 48.91 64.56 93.7 4.3

[0060] Comparative Example 1

[0061] Component formula: 0 parts of polygonatum extract, 2.0 parts of supramolecular NaDES, and other components are the same as those in Example 3.

[0062] Preparation method: same as Example 1.

[0063] Comparative Example 2

[0064] Component formula: 0 parts of supramolecular NaDES, 2.0 parts of polygonatum sibiricum extract, and other components are the same as those in Example 3.

[0065] Preparation method: same as Example 1.

[0066] Comparative Example 3

[0067] Component formula: 6.0 parts of Polygonatum sibiricum extract, and other components are the same as those in Example 3.

[0068] Preparation method: same as Example 1.

[0069] The comparative test results are shown in Table 3.

[0070] Table 3

[0071] Group Wrinkle reduction rate in week 3 Wrinkle reduction rate in week 6 Stability (activity retention) Skin feel score Comparative Example 1 8.12 12.33 82.4 3.5 Comparative Example 2 38.43 41.36 85.1 3.8 Comparative Example 3 16.58 20.41 79.6 2.9

[0072] It can be seen from Examples 1-5 and Comparative Examples 1-3 that the synergistic effect of Polygonatum sibiricum extract and supramolecular NaDES (Example 3) optimizes the anti-aging effect (wrinkle reduction rate of 67.37% in the 6th week). The absence of Polygonatum sibiricum extract leads to loss of anti-aging effect, while the absence of supramolecular NaDES leads to insufficient permeability. The excess of Polygonatum sibiricum extract causes precipitation problems.

Claims

1. An anti-aging facial mask composition containing supramolecular polygonatum extract, characterized in that: The following components are included in parts by mass: Polygonatum sibiricum extract: 0.5-5.0 parts; Supramolecular NaDES: 0.5-5.0 parts, wherein the supramolecular NaDES is prepared by reacting matrine with oxoglutaric acid in a molar ratio of 1:0.2-5; Acetyl hexapeptide-8: 0.1-1.0 parts; Conopeptide: 0.05-0.1 parts; Moisturizer: 8-16 parts; Preservatives: 0.01-0.5 parts; Thickener: 2-5 parts; Water: 40-90 parts.

2. The anti-aging facial mask composition containing the supramolecular Polygonatum sibiricum extract according to claim 1, characterized in that: The supramolecular NaDES is prepared by the following steps: matrine and oxoglutaric acid are mixed according to the molar ratio, and the mixture is stirred and heated at 50-80° C. for 3-12 hours to obtain a viscous liquid.

3. The anti-aging facial mask composition containing the supramolecular polygonatum extract according to claim 1 or 2, characterized in that: Also includes: pH adjuster: 0-1 part, one or more selected from L-arginine, citric acid, tartaric acid, and lactic acid; Chelating agent: 0-0.8 parts, which is disodium EDTA.

4. The anti-aging facial mask composition containing the supramolecular Polygonatum sibiricum extract according to claim 1, characterized in that: The moisturizing agent is selected from at least one of glycerin, 1,3-butylene glycol, sodium hyaluronate, trehalose, and betaine.

5. The anti-aging facial mask composition containing the supramolecular Polygonatum sibiricum extract according to claim 1, characterized in that: The preservative is selected from at least one of phenoxyethanol, chlorphenesin, and caprylhydroxamic acid.

6. The anti-aging facial mask composition containing the supramolecular Polygonatum sibiricum extract according to claim 1, characterized in that: The thickener is a combination of carbomer and xanthan gum, and the mass ratio of carbomer to xanthan gum is 1:0.5-2.

7. A method for preparing the anti-aging facial mask composition containing the supramolecular polygonatum extract according to any one of claims 1 to 6, characterized in that: The following steps are involved: (1) Mixing a polygonatum extract, supramolecular NaDES, a pH adjuster, and water, and stirring at 50-80° C. for 25-40 minutes to obtain a mixture A; (2) mixing the chelating agent, moisturizing agent, and preservative, and stirring at the same temperature for 25 to 40 minutes to obtain a mixture B; (3) Homogenize mixture A and mixture B for 15 to 30 seconds, cool to 20 to 40°C, age at room temperature for 2 hours, and then fill.

8. The preparation method according to claim 7, characterized in that: The pressure of the homogenization treatment is 10-50 MPa, and the mixing temperature of the mixture A and the mixture B is 50-80°C.

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