High-elasticity and high-biocompatibility skin elastic material and preparation method thereof

Abstract

The invention relates to the technical field of simulated skin, in particular to a high-elasticity and high-biocompatibility skin elastic material and a preparation method thereof, the tensile strength can reach 15-25 MPa, the elongation at break can reach 500-800%, and the elasticity recovery rate can still be kept at 95% or above after the skin elastic material is repeatedly pulled for 1000 times. Compared with a traditional material, under the same using condition, the elasticity decline speed of the material is obviously slowed down, the service life is greatly prolonged, and the cell survival rate of the material is larger than 95%. In an animal implantation experiment, an experimental animal implanted with the material does not have obvious inflammatory response and tissue damage, good biological safety of the material is proved, conventional stirring, extrusion and hot press molding processes are adopted, complex equipment and special process conditions are not needed, the production cost is low, and the material is suitable for large-scale industrial production. Compared with an existing complex preparation process, the production period is shortened by 30%-50%, and the production efficiency is remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of simulated skin, and in particular to a skin elastic material with high elasticity and high biocompatibility and a preparation method thereof. Background Art

[0002] At present, the existing simulated skin elasticity materials have many shortcomings. In the application of medical cosmetic prostheses, some materials have poor elasticity and durability, and are prone to deformation and loss of elasticity after long-term use, affecting the use effect and aesthetics; in terms of biocompatibility, some materials may cause adverse reactions such as allergies and inflammation when in contact with human tissue; and the preparation process of most materials is complicated and the production cost is high, which limits their large-scale application. For example, in the existing technology, although it has a certain elasticity, it has poor biocompatibility and is prone to rejection after implantation in the human body. In addition, in the existing technology, its preparation process requires special reaction equipment and strict environmental control, resulting in low production efficiency and high cost. Therefore, there is an urgent need to develop a skin elasticity material that has excellent elasticity, high biocompatibility and a simple preparation process. Summary of the Invention

[0003] The purpose of the present invention is to provide a skin elastic material with high elasticity and high biocompatibility and a preparation method thereof, so as to solve the problems raised in the background art and facilitate promotion.

[0004] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is:

[0005] A skin elastic material with high elasticity and high biocompatibility is composed of the following components in parts by weight: 40-60 parts of thermoplastic polyurethane, 20-30 parts of silicone rubber, 5-15 parts of nanocellulose, 3-8 parts of bioactive glass, 2-5 parts of plasticizer, and 1-3 parts of crosslinking agent.

[0006] Furthermore, the thermoplastic polyurethane is a polyether thermoplastic polyurethane with a number average molecular weight of 10,000-20,000.

[0007] Furthermore, the silicone rubber is vinyl silicone rubber, and the vinyl content is 0.1-0.5 mol%.

[0008] Furthermore, the nanocellulose has a diameter of 10-50 nm and a length of 100-500 nm.

[0009] Furthermore, the particle size of the bioactive glass is 1-5 μm, and its chemical composition is: SiO2 50-60 wt%, CaO 20-30 wt%, P2O5 10-15 wt%, Na2O 5-10 wt%.

[0010] 6. The skin elastic material with high elasticity and high biocompatibility according to claim 1, wherein the plasticizer is dioctyl phthalate.

[0011] Furthermore, the cross-linking agent is hydrogen-containing silicone oil, and the hydrogen content is 0.1-0.3 wt%.

[0012] A method for preparing a skin elastic material with high elasticity and high biocompatibility, characterized by comprising the following steps:

[0013] Step (1): adding thermoplastic polyurethane, silicone rubber, nanocellulose, bioactive glass, and plasticizer into a high-speed blender, stirring at 80-100° C. for 30-60 minutes, and mixing uniformly;

[0014] Step (2): adding a crosslinking agent to the above mixture and continuing stirring for 10-20 minutes;

[0015] Step (3): transferring the mixture to a twin-screw extruder, performing melt extrusion at 180-220° C., and extruding into granules;

[0016] Step (4): hot-pressing the granulated material in a mold at a molding temperature of 150-180° C., a molding pressure of 5-10 MPa, and a holding time of 10-20 min to obtain a skin elastic material.

[0017] Furthermore, the stirring speed of the high-speed mixer is 800-1200 r / min, and the screw speed of the twin-screw extruder is 100-200 r / min.

[0018] Furthermore, in the step (3), the aspect ratio of the twin-screw extruder is 25-40, and before the hot pressing molding, the granulated material is preheated at a temperature of 80-120° C. for a time of 5-15 minutes.

[0019] As an improvement, the beneficial effects of the present invention are:

[0020] 1. High Elasticity: The synergistic effect of thermoplastic polyurethane and silicone rubber imparts the material with excellent elastic properties. Testing has shown that the skin elastic material prepared in this invention has a tensile strength of 15-25 MPa and an elongation at break of 500-800%. Even after repeated stretching for 1,000 times, its elastic recovery rate remains above 95%. Compared with traditional materials, under the same operating conditions, the elasticity of this material declines significantly slower, significantly extending its service life.

[0021] 2. High biocompatibility: The addition of bioactive glass promotes the material's integration with human tissue, reducing the likelihood of rejection. Furthermore, the introduction of nanocellulose further improves the material's biocompatibility. Cytotoxicity testing demonstrated a cell survival rate exceeding 95%. In animal implantation experiments, the material showed no significant inflammatory reactions or tissue damage, demonstrating its excellent biosafety.

[0022] 3. Simple preparation process: The present invention utilizes conventional stirring, extrusion, and hot pressing processes, eliminating the need for complex equipment and specialized processing conditions. This reduces production costs and makes it suitable for large-scale industrial production. Compared to existing complex preparation processes, the present invention shortens production cycles by 30%-50%, significantly improving production efficiency.

[0023] 4. Strong controllability: By adjusting the proportion of each component and the preparation process parameters, the elasticity, hardness, biocompatibility and other properties of the material can be flexibly controlled according to different application requirements, broadening the application range of the material. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 A comparison diagram of a skin elastic material with high elasticity and high biocompatibility and its preparation method of the present invention; DETAILED DESCRIPTION

[0025] In order to make the contents of the present invention more clearly understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0026] Example 1

[0027] 1. Weigh 50 parts of thermoplastic polyurethane (number average molecular weight 12,000), 25 parts of vinyl silicone rubber (vinyl content 0.2 mol%), 10 parts of nanocellulose (diameter 20 nm, length 200 nm), 5 parts of bioactive glass (particle size 2 μm, chemical composition: SiO2 55 wt%, CaO 25 wt%, P2O5 12 wt%, Na2O 8 wt%), and 3 parts of dioctyl phthalate into a high-speed blender and stir at 90°C for 45 min to mix thoroughly.

[0028] 2. Add 2 parts of hydrogenated silicone oil (hydrogen content 0.2 wt%) to the above mixture and continue stirring for 15 minutes;

[0029] 3. Transfer the mixture to a twin-screw extruder, melt extrude at 200°C, and extrusion granulate;

[0030] 4. The granulated material is hot-pressed in a mold at a molding temperature of 165° C., a molding pressure of 7 MPa, and a holding time of 15 min to obtain a skin elastic material.

[0031] Example 2

[0032] 1. Weigh 45 parts of thermoplastic polyurethane (number average molecular weight 15,000), 28 parts of vinyl silicone rubber (vinyl content 0.3 mol%), 8 parts of nanocellulose (diameter 30 nm, length 300 nm), 6 parts of bioactive glass (particle size 3 μm, chemical composition: SiO2 58 wt%, CaO 23 wt%, P2O5 11 wt%, Na2O 8 wt%), and 4 parts of dioctyl phthalate into a high-speed blender and stir at 85°C for 50 min to mix thoroughly.

[0033] 2. Add 2.5 parts of hydrogenated silicone oil (hydrogen content 0.25 wt%) to the above mixture and continue stirring for 12 minutes;

[0034] 3. Transfer the mixture to a twin-screw extruder, melt extrude at 210°C, and extrusion granulate;

[0035] 4. The granulated material is hot-pressed in a mold at a molding temperature of 170° C., a molding pressure of 8 MPa, and a holding time of 18 min to obtain a skin elastic material.

[0036] Example 3

[0037] 1. Weigh 40 parts of thermoplastic polyurethane (number average molecular weight 10,000), 30 parts of vinyl silicone rubber (vinyl content 0.1 mol%), 15 parts of nanocellulose (diameter 10 nm, length 100 nm), 3 parts of bioactive glass (particle size 1 μm, chemical composition: SiO2 50 wt%, CaO 30 wt%, P2O5 15 wt%, Na2O 5 wt%), and 2 parts of dioctyl phthalate into a high-speed blender and stir at 80°C for 60 min to mix thoroughly.

[0038] 2. Add 1 part of hydrogenated silicone oil (hydrogen content 0.1 wt%) to the above mixture and continue stirring for 20 min;

[0039] 3. Transfer the mixture to a twin-screw extruder, melt extrude at 180°C, and extrusion granulate;

[0040] 4. The granulated material is hot-pressed in a mold at a molding temperature of 150° C., a molding pressure of 5 MPa, and a holding time of 20 min to obtain a skin elastic material.

[0041] Example 4

[0042] 1. Weigh 60 parts of thermoplastic polyurethane (number average molecular weight 20,000), 20 parts of vinyl silicone rubber (vinyl content 0.5 mol%), 5 parts of nanocellulose (diameter 50 nm, length 500 nm), 8 parts of bioactive glass (particle size 5 μm, chemical composition: SiO2 60 wt%, CaO 20 wt%, P2O5 10 wt%, Na2O 10 wt%), and 5 parts of dioctyl phthalate into a high-speed blender and stir at 100°C for 30 min to mix thoroughly.

[0043] 2. Add 3 parts of hydrogenated silicone oil (hydrogen content 0.3 wt%) to the above mixture and continue stirring for 10 minutes;

[0044] 3. Transfer the mixture to a twin-screw extruder, melt extrude at 220°C, and extrusion granulate;

[0045] 4. The granulated material is hot-pressed in a mold at a molding temperature of 180° C., a molding pressure of 10 MPa, and a holding time of 10 min to obtain a skin elastic material.

[0046] Comparative Example 1

[0047] The raw material composition is: 30 parts of polyurethane, 40 parts of rubber, and 30 parts of additives. The preparation is carried out according to the process conditions of the patent.

[0048] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included in the scope of protection of the present invention.

Claims

1. A skin elastic material with high elasticity and high biocompatibility, characterized in that: The invention is composed of the following components in parts by weight: 40-60 parts of thermoplastic polyurethane, 20-30 parts of silicone rubber, 5-15 parts of nanocellulose, 3-8 parts of bioactive glass, 2-5 parts of plasticizer and 1-3 parts of crosslinking agent.

2. The skin elastic material with high elasticity and high biocompatibility according to claim 1, characterized in that: The thermoplastic polyurethane is a polyether thermoplastic polyurethane with a number average molecular weight of 10,000-20,000.

3. The skin elastic material with high elasticity and high biocompatibility according to claim 1, characterized in that: The silicone rubber is vinyl silicone rubber, and the vinyl content is 0.1-0.5 mol%.

4. The skin elastic material with high elasticity and high biocompatibility according to claim 1, characterized in that: The diameter of the nanocellulose is 10-50 nm and the length is 100-500 nm.

5. The skin elastic material with high elasticity and high biocompatibility according to claim 1, characterized in that: The particle size of the bioactive glass is 1-5 μm, and its chemical composition is: SiO2 50-60 wt%, CaO 20-30 wt%, P2O5 10-15 wt%, and Na2O 5-10 wt%.

6. The skin elastic material with high elasticity and high biocompatibility according to claim 1, characterized in that: The plasticizer is dioctyl phthalate.

7. The skin elastic material with high elasticity and high biocompatibility according to claim 3, characterized in that: The cross-linking agent is hydrogen-containing silicone oil, and the hydrogen content is 0.1-0.3 wt%.

8. The method for preparing a skin elastic material with high elasticity and high biocompatibility according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step (1): adding thermoplastic polyurethane, silicone rubber, nanocellulose, bioactive glass, and plasticizer into a high-speed blender, stirring at 80-100° C. for 30-60 minutes, and mixing uniformly; Step (2): adding a crosslinking agent to the above mixture and continuing stirring for 10-20 minutes; Step (3): transferring the mixture to a twin-screw extruder, performing melt extrusion at 180-220° C., and extruding into granules; Step (4): hot-pressing the granulated material in a mold at a molding temperature of 150-180° C., a molding pressure of 5-10 MPa, and a holding time of 10-20 min to obtain a skin elastic material.

9. The method for preparing a skin elastic material with high elasticity and high biocompatibility according to claim 8, characterized in that: The stirring speed of the high-speed mixer is 800-1200 r / min, and the screw speed of the twin-screw extruder is 100-200 r / min.

10. The method for preparing a skin elastic material with high elasticity and high biocompatibility according to claim 8, characterized in that: In the step (3), the aspect ratio of the twin-screw extruder is 25-40, and before the hot pressing molding, the granulated material is preheated at a temperature of 80-120° C. for a time of 5-15 minutes.

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