Method for hydrogenation reaction of specific component squalene in multicoloured leaf extract and application thereof

Abstract

The invention relates to the technical field of multicoloured leaves, and discloses a method for hydrogenation reaction of a specific component squalene in a multicoloured leaf extract and application of the multicoloured leaf extract, and the method comprises the following steps: dissolving the multicoloured leaf extract containing squalene in a solvent of water, methanol, ethanol, normal hexane, cyclohexane or tetrahydrofuran, so that the mass ratio of the extract to the solvent is 10: 100 to 50: 100; a supported spinel structure catalyst is added into the solution, the catalyst is selected from CoFe2O4, CuFe2O4, CoMn2O4, NiMn2O4, CuCo2O4 or NiAl2O4, and the mass ratio of the catalyst to the extract ranges from 1: 50 to 1: 500. By adopting a selective hydrogenation catalytic system with spinel structure supported multi-metal oxide as a core, the effect of accurate hydro-conversion of squalene in the multicoloured leaf extract is achieved, and the problems that the hydrogenation selectivity is low and the product purity is difficult to guarantee are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of Paniculata spp., in particular to a method for hydrogenation reaction of squalene, a specific component of Paniculata spp. extract and application thereof. Background Art

[0002] In the field of natural plant resource development, Panax notoginseng has attracted widespread attention because it is rich in various functional bioactive ingredients. Its extracts contain unsaturated lipid compounds such as squalene, neophytadiene, phytol, and linoleic acid. Among them, squalene is prone to oxidative degradation in the air due to its multiple carbon-carbon double bond structure, which not only affects its storage stability, but also limits its in-depth application in food additives, cosmetics, health care products and other fields. Therefore, in order to improve its stability and safety, the industry generally uses hydrogenation treatment to convert squalene into squalane derivatives with more stable structure and milder properties, thereby achieving a balance between function retention and application adaptability.

[0003] Panicum variegatum leaf extract has a complex composition, containing multiple coexisting components with similar reactivity. Traditional hydrogenation processes often face the problem of difficult selectivity control when dealing with such multi-component systems. Currently commonly used hydrogenation catalysts such as Pd / C, Ni-based or Pt-based metal-supported catalysts, although they perform well in terms of hydrogenation reaction activity, are insufficient in their recognition and catalytic ability for specific targeted components in composite natural extract systems. They are prone to simultaneous hydrogenation of non-target components (such as neophytadiene and linoleic acid), resulting in a decrease in product purity and an increase in reaction by-products, ultimately affecting the yield and functional properties of the target product.

[0004] In addition, most existing commercial catalysts have non-adjustable structures, and active metal sites are prone to agglomeration and deactivation, resulting in poor reusability and making it difficult to meet the needs of green, efficient and stable industrial transformation. Summary of the Invention

[0005] In response to the shortcomings of the existing technology, the present invention provides a method for the hydrogenation reaction of squalene, a specific component of the Paniculata leaf extract, and its application, which solves the problems that the Paniculata leaf extract has complex components, traditional hydrogenation catalysts have low selectivity for the hydrogenation of squalene, and there are side reactions of hydrogenation of other active substances.

[0006] To achieve the above objectives, the present invention is implemented by the following technical scheme: a method for hydrogenating squalene, a specific component of Paniculata leaf extract, comprising:

[0007] Dissolving the Panicum dahliae leaf extract containing squalene in a solvent selected from water, methanol, ethanol, n-hexane, cyclohexane or tetrahydrofuran to prepare a solution having a mass ratio of the extract to the solvent of 10:100 to 50:100;

[0008] Adding a supported spinel structure catalyst to the solution, wherein the catalyst is selected from CoFe2O4, CuFe2O4, CoMn2O4, NiMn2O4, CuCo2O4 or NiAl2O4, and the mass ratio of the catalyst to the extract is 1:50 to 1:500;

[0009] The mixed system is placed in a high-pressure reactor and reacted for 110 hours at a hydrogen pressure of 2 to 10 MPa and a temperature of 40° C. to 140° C. to obtain a hydrogenated product of squalene.

[0010] Furthermore, the present invention adopts a solvent extraction method to effectively extract squalene from the variegated leaves. On the basis of selecting an appropriate solvent, the mass ratio of the extract to the solvent is controlled to ensure that the squalene component is fully dissolved. The selected solvent can effectively dissolve non-polar to medium-polar components and avoid dissolving water-soluble impurities, thereby ensuring the high efficiency and selectivity of the hydrogenation reaction. The introduction of a supported spinel structure catalyst is the core innovation of the present invention. The spinel structure of the catalyst provides rich active sites, which helps to improve the rate and selectivity of the hydrogenation reaction. The hydrogen can be fully activated under the high pressure conditions in the reactor, and the hydrogenation reaction is carried out at a suitable temperature and time, thereby effectively converting squalene into a hydrogenated product.

[0011] Preferably, the catalyst is prepared by the following method:

[0012] The metal precursors A and B are dissolved in water at a molar ratio of 1:0.5 to 1:4, and one of ethanol, ethylene glycol, 2-methylformamide, diethylamine or glycerol is added as a small molecule template, with the molar ratio of A to the template being 1:100 to 1:2000;

[0013] NaOH and Na2CO3 were added as precipitants to the mixed solution, the pH was controlled to 12, and the mixture was stirred and precipitated for 2 hours;

[0014] The stirred suspension is transferred to a hydrothermal reactor and hydrothermally treated at a temperature of 100 to 200° C. for 8 to 20 hours;

[0015] The hydrotalcite precursor was obtained by filtering, washing, and drying at 80°C for 10 hours;

[0016] The dried solid is placed in a muffle furnace for calcination, the temperature is raised to 300-800° C. at a rate of 5-10° C. / min, the temperature is maintained for 2-8 hours, and the spinel catalyst is obtained by grinding after calcination.

[0017] Furthermore, during the preparation of the catalyst, a small molecule template is used to regulate the distribution and morphology of the metal precursor, which is an important innovation of the present invention. By introducing the template, the surface properties and pore structure of the catalyst can be precisely controlled, which is crucial for the selectivity of the catalytic reaction. The precipitation reaction is carried out under specific pH conditions, which can promote the full precipitation of metal ions as precursors, and the hydrothermal treatment process provides the necessary conditions for the formation of the crystal structure of the catalyst. Through high-temperature calcination, the precursor is converted into a spinel-structured catalyst, which enhances the stability and efficiency of the catalyst and ensures the smooth progress of the subsequent hydrogenation reaction.

[0018] Preferably, during the preparation of the catalyst, the precipitation reaction is carried out by stirring with a magnetic stirrer at room temperature. After the reaction is completed, the resulting suspension is filtered through a vacuum filtration device, and the filter cake is washed 3 to 5 times with deionized water until the pH of the filtrate is neutral. The washed solid is then placed in a forced air drying oven to obtain a hydrotalcite precursor, wherein the catalyst is a spinel structured CuFe2O4.

[0019] Furthermore, the magnetic stirrer provides uniform stirring conditions, making the metal precursor more evenly distributed in the solution, avoiding the risk of uneven precipitation leading to fluctuations in catalyst performance. Vacuum filtration and deionized water washing can not only effectively remove impurities, but also prevent the impact of residual byproducts of the metal precursor on catalytic performance. The drying process helps to remove solvents and moisture, ensuring the stability of the catalyst precursor. Subsequently, calcination at high temperature converts it into a spinel-structured CuFe2O4 catalyst, improving the efficiency of its catalytic reaction.

[0020] Preferably, the mass ratio of the squalene extract in the reaction system to the active metal in the catalyst is 1:100 to 1:1000.

[0021] Furthermore, the present invention ensures the efficient progress of the catalytic reaction by precisely controlling the mass ratio of squalene extract to the active metal in the catalyst. At a lower mass ratio of catalyst to squalene, excessive use of the catalyst can be effectively avoided, reducing costs while still ensuring the high efficiency of the hydrogenation reaction. The appropriate active metal ratio ensures that the catalyst can fully interact with the squalene molecules, thereby improving the selectivity of the reaction and the purity of the product.

[0022] Preferably, the NaOH concentration of the precipitant solution is 0.1-0.5 mol / L, and the Na2CO3 concentration is 0.4-1.2 mol / L.

[0023] Furthermore, the concentration of the precipitant has an important influence on the formation of the catalyst. By rationally adjusting the concentrations of NaOH and Na2CO3, the rate of the precipitation reaction and the degree of precipitation of metal ions can be effectively controlled to ensure the purity and quality of the catalyst precursor. The appropriate precipitant concentration contributes to the uniform distribution of the catalyst and the stability of the crystal structure, thereby enhancing the activity of the catalyst.

[0024] Preferably, the reaction system is carried out under stirring conditions with a stirring rate of 300 to 800 rpm.

[0025] Furthermore, the optimization of the stirring rate helps to improve the contact efficiency between the reactants and the catalyst in the reaction system. A higher stirring rate helps to increase the collision frequency between the reactant molecules and the catalyst, promotes the adsorption and dissociation of hydrogen molecules, and thus accelerates the hydrogenation reaction. The appropriate stirring rate ensures the uniformity of the reaction and avoids the precipitation or uneven distribution of the substance.

[0026] Preferably, the product after the hydrogenation reaction is separated and extracted by solvent evaporation, rotary distillation or reduced pressure concentration, wherein:

[0027] The solvent evaporation is carried out at a temperature of 50°C to 70°C under normal pressure or reduced pressure until no obvious solvent remains in the system;

[0028] The rotary distillation is operated at a temperature of 40°C to 65°C, a vacuum degree of -0.08MPa to -0.095MPa, and a rotation speed of 80 to 150rpm to recover the reaction solvent and enrich the hydrogenation product;

[0029] The reduced pressure concentration operation temperature is controlled at 45° C. to 60° C. and is carried out under vacuum conditions of -0.07 MPa to -0.09 MPa, and the volume of the original reaction liquid is concentrated to 10% to 30%, and the concentrated liquid is used for subsequent purification or direct use.

[0030] Furthermore, the combination of solvent evaporation, rotary distillation, and vacuum concentration can efficiently remove the solvent used in the reaction, preventing the impact of residual solvent on product purity, while simultaneously enriching the hydrogenation reaction product. Both rotary distillation and vacuum concentration can be performed at low temperatures, effectively preventing product degradation or volatilization caused by excessive temperatures. Through the rational application of these separation techniques, the purity and effectiveness of the reaction products are ensured.

[0031] Preferably, the A and B metal precursors are any combination of Co(NO3)2, Fe(NO3)3, Cu(NO3)2, Ni(NO3)2 or Al(NO3)3 in the form of nitrates.

[0032] Furthermore, metal precursors in the form of nitrates have good solubility, which facilitates the uniform distribution of metal ions in the solution, thereby affecting the morphology and performance of the catalyst. By selecting different metal precursors, the composition and performance of the catalyst can be adjusted to adapt to different reaction requirements.

[0033] Preferably, the initial particle size of the catalyst in the reaction system is controlled between 10 and 200 nm.

[0034] Furthermore, the particle size of the catalyst directly affects its surface area and reactivity. Within a smaller particle size range, the number of active sites on the catalyst surface increases, allowing reactants to more fully contact the catalyst, thereby improving catalytic efficiency. Appropriate particle size control helps improve the rate and selectivity of hydrogenation reactions.

[0035] Preferably, the method for hydrogenation reaction of squalene, a specific component of the Panicum tiliaceum leaf extract, is applied to stabilization, solubilization or functionalization modification of squalene, and is used for modification of the Panicum tiliaceum leaf extract in food additives, cosmetics, nutritional health products or pharmaceutical raw materials.

[0036] The present invention provides a method and application for the hydrogenation reaction of squalene, a specific component of Paniculata leaf extract. It has the following beneficial effects:

[0037] 1. This invention utilizes a selective hydrogenation catalytic system based on a spinel-structured multimetallic oxide to achieve precise hydrogenation conversion of squalene from Panicum variegatum leaf extract. Conventional catalysts have poor recognition of active substances in multi-component systems, often leading to frequent non-target reactions. This invention addresses the issues of low hydrogenation selectivity and difficulty ensuring product purity.

[0038] 2. By introducing a multifunctional small molecule template to control the distribution of metal ions, this invention creates a uniformly dispersed catalyst microstructure with controllable crystal form, thereby improving catalyst stability and sustained reaction activity. Compared with existing metal catalyst solutions that suffer from severe particle agglomeration and poor reusability, this approach effectively overcomes key bottlenecks such as short catalytic life and reduced conversion rate.

[0039] 3. This invention utilizes mild hydrogenation conditions in conjunction with a solvent system to avoid damaging heat-sensitive components during the reaction, achieving stable conversion of squalene. Common commercial technologies often rely on high temperatures or strong acid-base reaction environments, which not only lead to component degradation but also compromise product safety. This solution effectively avoids these uncontrollable negative effects.

[0040] 4. This invention utilizes a pH-adjustable co-precipitation strategy combined with hydrothermal conversion to produce a catalyst with excellent crystallinity and pore structure, achieving precise catalysis in complex plant extracts. Unlike previous practices that indiscriminately utilize commercial oxide catalysts, this invention addresses the problem of unstable reaction activity due to structural disorganization, significantly improving the controllability and practicality of the catalytic process. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 is a flow chart of the method of the present invention;

[0042] Figure 2 This is the squalene hydrogenation route of the present invention. DETAILED DESCRIPTION

[0043] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the present specification. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0044] Please see the attached Figure 1 -Attached Figure 2 :

[0045] Example 1

[0046] Co(NO3)2 (precursor A) and Fe(NO3)3 (precursor B) precursors were dissolved in a certain amount of water, with the molar ratio of Co to Fe being 1:3; NaOH and Na2CO3 were dissolved in a certain amount of water at the same time, with the concentration of NaOH being 0.25 mol / L and the concentration of Na2CO3 being 0.8 mol / L; 2-methylformamide was added to the Co(NO3)3 and Fe(NO3)3 solutions as a small molecule template, with the molar ratio of Co to Fe and 2-methylformamide being 1:200; Co(NO3) 3 and Fe(NO3)3 solutions were dropwise mixed with a mixed solution of NaOH and Na2CO3. The pH was controlled at 12 by the dropwise addition rate of the precipitant. After precipitation was complete, the mixture was stirred for 2 hours. The stirred suspension was transferred to a hydrothermal reactor and hydrothermally treated at 160°C for 15 hours. The CoFe hydrotalcite precursor was obtained by filtration, washing, and drying at 80°C for 10 hours. The dried solid was calcined in a muffle furnace, heated to 600°C at a rate of 10°C / min, maintained for 6 hours, and ground after calcination to obtain a CoFe2O4 spinel catalyst. The same steps were used to prepare CuFe2O4, CoMn2O4, NiMn2O4, and CuCo2O4 spinel catalysts.

[0047] In a 25 mL stainless steel autoclave, 3 g of Paniculata leaf extract, 0.05 g of the above catalyst, and a certain amount of ethanol as solvent were added to a total reaction volume of 15 mL. After sealing the reactor, H2 was injected at 25 MPa and heated to 100°C for 4 hours. After the reaction was completed, the reaction solution was cooled to room temperature and the product types and concentrations were analyzed by gas chromatography, as shown in Table 1.

[0048] The squalene conversion rate was calculated by the following formula:

[0049] Conversion rate = (initial molar concentration of reactant - final molar concentration of reactant) / initial molar concentration of reactant × 100%

[0050] Squalane selectivity was calculated by the following formula:

[0051] Selectivity = final molar concentration of squalane / (initial molar concentration of squalene - final molar concentration of squalene) × 100%;

[0052] Table 1 Conversion rate of each component and selectivity of squalane in hydrogenation reaction of Panicum tiliaceum extract under different catalysts:

[0053]

[0054] As can be seen from Table 1, the CoMn2O4 catalyst exhibits good performance and can achieve selective hydrogenation of squalene while obtaining extremely high selectivity for squalane. The NiMn2O4 catalyst also has strong hydrogenation ability, but also has the ability to hydrogenate other substances, and its selective hydrogenation ability for squalene is not high.

[0055] Example 2

[0056] Co(NO3)2 (precursor A) and Mn(NO3)2 (precursor B) were dissolved in a certain amount of water, respectively, with the molar ratio of Co to Mn being 1:3; NaOH and Na2CO3 were dissolved in a certain amount of water at the same time, with the concentration of NaOH being 0.25 mol / L and the concentration of Na2CO3 being 0.8 mol / L; 2-methylformamide was added to the Co(NO3)3 and Mn(NO3)3 solutions as a small molecule template, with the molar ratio of Co, Mn and 2-methylformamide being 1:200; Co(NO3)2 and Mn(NO3)3 were dissolved in a certain amount of water, with the molar ratio of Co to Mn being 1:3; NaOH and Na2CO3 were dissolved in a certain amount of water at the same time, with the concentration of NaOH being 0.25 mol / L and the concentration of Na2CO3 being 0.8 mol / L; 2-methylformamide was added to the Co(NO3)3 and Mn(NO3)3 solutions as a small molecule template, with the molar ratio of Co, Mn and 2-methylformamide being 1:200; 3) Solution 2 was dropwise mixed with a mixed solution of NaOH and Na2CO3, and the pH was controlled to 12 by the dropwise addition rate of the precipitant. After precipitation was complete, the suspension was stirred for 2 hours. The stirred suspension was transferred to a hydrothermal kettle and hydrothermally treated at 160°C for 15 hours. A CoMn hydrotalcite precursor was obtained by filtration, washing, and drying at 80°C for 10 hours. The dried solid was calcined in a muffle furnace, heated to 300°C at a rate of 10°C / min, and maintained for 6 hours. After calcination, the solid was ground to obtain a CoMn2O4 spinel catalyst, which was labeled CoMn2O4-300. The calcination temperature was changed to 400℃, 500℃, 600℃, 700℃ and 800℃ to prepare spinel catalysts with different calcination temperatures, which were marked as CoMn2O4-400, CoMn2O4-500, CoMn2O4-600, CoMn2O4-700 and CoMn2O4-800.

[0057] A 25 mL stainless steel autoclave was charged with 3 g of Paniculata leaf extract, 0.05 g of the above-mentioned catalyst, and a certain amount of ethanol as solvent. The total reaction volume was 15 mL. The reactor was sealed and flushed with 25 MPa of hydrogen. The reaction was heated to 100°C for 4 hours. After the reaction was completed, the reaction solution was cooled to room temperature and the product types and concentrations were analyzed by gas chromatography (Table 2). The conversion and selectivity formulas are the same as above.

[0058] Table 2 Conversion rate of each composition and selectivity of squalane in the hydrogenation reaction of Panax notoginseng extract under different calcined catalyst temperatures:

[0059]

[0060]

[0061] It can be seen from Table 2 that with the increase of calcination temperature, the activity of CoMn2O4 catalyst for squalene hydrogenation increases. When the calcination temperature is higher than 600℃, the activity of the catalyst decreases, which may be caused by the destruction of the crystal structure of spinel at higher temperatures.

[0062] Effect of reaction solvent

[0063] Example 3

[0064] A 25 mL stainless steel autoclave was charged with 3 g of Paniculata leaf extract and 0.05 g of CoMn2O4-600 catalyst. Ethanol, water, tetrahydrofuran, and cyclohexane were used as solvents, respectively, for a total reaction volume of 15 mL. The reactor was sealed and flushed with 25 MPa of H2O. The reaction was heated to 100°C for 4 hours. After the reaction was completed, the reaction solution was cooled to room temperature and the product types and concentrations were analyzed by gas chromatography (Table 3). The conversion and selectivity formulas are the same as above.

[0065] Table 3 Experimental results of hydrogenation of Panax notoginseng extract in different reaction solvents:

[0066]

[0067] As shown in Table 3, ethanol is the optimal solvent for the reaction. High squalene conversion and squalane selectivity can also be achieved in tetrahydrofuran. Water is less effective as a solvent, likely due to the low solubility of Paniculata leaf extract in water. Squalene conversion is also low in cyclohexane, likely due to the solvent's polarity.

[0068] Effect of reaction temperature

[0069] Comparative Example 1

[0070] A 25 mL stainless steel autoclave was charged with 3 g of Paniculata leaf extract, 0.05 g of CoMn2O4-600 catalyst, and a certain amount of ethanol as solvent. The total reaction volume was 15 mL. The reactor was sealed and flushed with 25 MPa of H2O. The reaction was heated to 100°C for 4 hours. After the reaction was completed, the reaction solution was cooled to room temperature and the product types and concentrations were analyzed by gas chromatography (Table 3). The conversion and selectivity formulas are the same as above.

[0071] Example 4

[0072] The reaction temperature was set to 40° C., and other conditions were the same as those in Comparative Example 1.

[0073] Example 5

[0074] The reaction temperature was set to 70° C., and other conditions were the same as those in Comparative Example 1.

[0075] Example 6

[0076] The reaction temperature was set to 90° C., and other conditions were the same as those in Comparative Example 1.

[0077] Example 7

[0078] The reaction temperature was set to 120° C., and other conditions were the same as those in Comparative Example 1.

[0079] Example 8

[0080] The reaction temperature was set to 140° C., and other conditions were the same as those in Comparative Example 1.

[0081] Table 4 Conversion rate of each substance in Panicum scabra extract and selectivity of squalane at different reaction temperatures:

[0082]

[0083]

[0084] As can be seen from Table 4, with the increase of reaction temperature, the conversion rate of squalene gradually increased. The reaction was basically complete at 120 °C. However, when the temperature was greater than 100 °C, neophytadiene began to hydrogenate. This may be because squalene and neophytadiene had a competitive adsorption relationship. When squalene was present, it occupied the main hydrogenation active sites, inhibiting the hydrogenation of neophytadiene. After squalene was completely consumed, neophytadiene began to react. It may also be because the active sites at high temperature have hydrogenation activity for neophytadiene, while the hydrogenation sites at lower temperatures do not have hydrogenation activity for neophytadiene.

[0085] Effect of reaction pressure

[0086] Example 9

[0087] The pressure of H2 was increased to 2 MPa, and other conditions were the same as those in Comparative Example 1.

[0088] Example 10

[0089] The pressure was increased to 8 MPa, and other conditions were the same as those in Comparative Example 1.

[0090] Example 11

[0091] The pressure of H2 was increased to 10 MPa, and other conditions were the same as those in Comparative Example 1.

[0092] Table 5 Conversion rate of each substance in Panicum scabra extract and selectivity of squalane under different H2 pressures:

[0093]

[0094]

[0095] It can be seen from Table 5 that the H2 pressure has little effect on the reaction. The lower conversion rate of squalene at 2 MPaH2 is due to the complete consumption of hydrogen.

[0096] The impact of reaction time

[0097] Example 12

[0098] The reaction time was set to 1 hour, and other conditions were the same as those in Comparative Example 1.

[0099] Example 13

[0100] The reaction time was set to 2 hours, and other conditions were the same as those in Comparative Example 1.

[0101] Example 14

[0102] The reaction time was set to 6 hours, and other conditions were the same as those in Comparative Example 1.

[0103] Example 15

[0104] The reaction time was set to 8 hours, and other conditions were the same as those in Comparative Example 1.

[0105] Example 16

[0106] The reaction time was set to 10 hours, and other conditions were the same as those in Comparative Example 1.

[0107] Table 6 Conversion rate of each substance in Pandan leaf extract and selectivity of squalane at different reaction times:

[0108]

[0109]

[0110] As can be seen from Table 6, with the increase of reaction time, the conversion rate of squalene continues to increase. Squalene is basically reacted completely after 6 hours of reaction, and further extension of the reaction time has no effect on the reaction.

[0111] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A method for hydrogenating squalene, a specific component of Panicum scabra leaf extract, characterized in that: include: Dissolving the Panicum dahliae leaf extract containing squalene in a solvent selected from water, methanol, ethanol, n-hexane, cyclohexane or tetrahydrofuran to prepare a solution having a mass ratio of the extract to the solvent of 10:100 to 50:100; Adding a supported spinel structure catalyst to the solution, wherein the catalyst is selected from CoFe2O4, CuFe2O4, CoMn2O4, NiMn2O4, CuCo2O4 or NiAl2O4, and the mass ratio of the catalyst to the extract is 1:50 to 1:500; The mixed system is placed in a high-pressure reactor and reacted for 110 hours at a hydrogen pressure of 2 to 10 MPa and a temperature of 40° C. to 140° C. to obtain a hydrogenated product of squalene.

2. The method for hydrogenating squalene, a specific component of Panicum scabra leaf extract according to claim 1, characterized in that: The catalyst is prepared by the following method: The metal precursors A and B are dissolved in water at a molar ratio of 1:0.5 to 1:4, and one of ethanol, ethylene glycol, 2-methylformamide, diethylamine or glycerol is added as a small molecule template, with the molar ratio of A to the template being 1:100 to 1:2000; NaOH and Na2CO3 were added as precipitants to the mixed solution, the pH was controlled to 12, and the mixture was stirred and precipitated for 2 hours; The stirred suspension is transferred to a hydrothermal reactor and hydrothermally treated at a temperature of 100 to 200° C. for 8 to 20 hours; The hydrotalcite precursor was obtained by filtering, washing, and drying at 80°C for 10 hours; The dried solid is placed in a muffle furnace for calcination, the temperature is raised to 300-800° C. at a rate of 5-10° C. / min, the temperature is maintained for 2-8 hours, and the spinel catalyst is obtained by grinding after calcination.

3. The method for hydrogenating squalene, a specific component of Paniculata leaf extract according to claim 1, characterized in that: During the preparation process of the catalyst, a precipitation reaction is carried out by stirring with a magnetic stirrer at room temperature. After the reaction is completed, the resulting suspension is filtered through a vacuum filtration device, and the filter cake is washed 3 to 5 times with deionized water until the pH of the filtrate is neutral. The washed solid is then placed in a forced air drying oven to obtain a hydrotalcite precursor. The catalyst is CuFe2O4 with a spinel structure.

4. The method for hydrogenating squalene, a specific component of Panicum scabra leaf extract according to claim 1, characterized in that: The mass ratio of the squalene extract in the reaction system to the active metal in the catalyst is 1:100 to 1:1000.

5. The method for hydrogenating squalene, a specific component of Paniculata leaf extract according to claim 2, characterized in that: The NaOH concentration of the precipitant solution is 0.1-0.5 mol / L, and the Na2CO3 concentration is 0.4-1.2 mol / L.

6. The method for hydrogenating squalene, a specific component of Paniculata leaf extract according to claim 1, characterized in that: The reaction system is carried out under stirring conditions with a stirring rate of 300 to 800 rpm.

7. The method for hydrogenating squalene, a specific component of Panicum scabra leaf extract according to claim 1, characterized in that: The product after the hydrogenation reaction is separated and extracted by solvent evaporation, rotary distillation or reduced pressure concentration, wherein: The solvent evaporation is carried out at a temperature of 50°C to 70°C under normal pressure or reduced pressure until no obvious solvent remains in the system; The rotary distillation is operated at a temperature of 40°C to 65°C, a vacuum degree of -0.08MPa to -0.095MPa, and a rotation speed of 80 to 150rpm to recover the reaction solvent and enrich the hydrogenation product; The reduced pressure concentration operation temperature is controlled at 45° C. to 60° C. and is carried out under vacuum conditions of -0.07 MPa to -0.09 MPa, and the volume of the original reaction liquid is concentrated to 10% to 30%, and the concentrated liquid is used for subsequent purification or direct use.

8. The method for hydrogenating squalene, a specific component of Paniculata leaf extract according to claim 1, characterized in that: The A and B metal precursors are any combination of Co(NO3)2, Fe(NO3)3, Cu(NO3)2, Ni(NO3)2 or Al(NO3)3 in the form of nitrates.

9. The method for hydrogenating squalene, a specific component of Paniculata leaf extract according to claim 1, characterized in that: The initial particle size of the catalyst in the reaction system is controlled between 10 and 200 nm.

10. The method for hydrogenation of squalene, a specific component of Panicum scabra extract according to claims 1-9, characterized in that: It is used for stabilization, solubilization or functionalization modification of squalene, and for modification of Panax notoginseng leaf extract in food additives, cosmetics, nutritional health products or pharmaceutical raw materials.

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