Preparation method and application of anti-Parkinson hydrogel preparation
By preparing bacterial outer membrane vesicles loaded with cerium metal polyphenol networks and mixing them with inulin to form a hydrogel preparation, the problems of brain oxidative stress and intestinal flora imbalance in Parkinson's disease were solved, and a synergistic therapeutic effect of the intestine and brain was achieved.
CN120585778APending Publication Date: 2025-09-05ZHENGZHOU UNIV
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Patent Information
- Application Number
- CN202510852675.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-24
- Publication Date
- 2025-09-05
AI Technical Summary
Technical Problem
Existing technologies have failed to effectively address the brain oxidative stress and intestinal flora imbalance problems of Parkinson's disease, and lack treatment options for both the gut and the brain.
Method used
By preparing bacterial outer membrane vesicles loaded with cerium metal polyphenol networks and mixing them with inulin, an anti-Parkinson's hydrogel preparation is formed for oral administration, which synergistically exerts antioxidant and anti-inflammatory effects in the intestine and brain.
Benefits of technology
Hydrogel preparations can regulate intestinal flora imbalance, reduce the expression of inflammatory factors in the brain, relieve Parkinson's symptoms, and achieve a therapeutic effect of gut-brain linkage.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to a preparation method and application of an anti-Parkinson hydrogel preparation, solves the problems of oxidative stress of the brain of Parkinson and dysbacteriosis of intestinal flora, and adopts the technical scheme that the anti-Parkinson hydrogel preparation is prepared by the following steps: extracting bacterial outer membrane vesicles of alcaligenes faecalis through an ultracentrifugation method; the preparation method comprises the following steps: complexing cerium ions and polyphenol substances into a metal polyphenol network, loading the cerium metal polyphenol network into bacterial outer membrane vesicles by a mechanical extrusion method, and finally mixing the substances with inulin to obtain the anti-Parkinson hydrogel preparation. The preparation conditions are mild, the process is simple, the method is stable and reliable, the production cost is low, a new thought for treating the Parkinson's disease is developed, and the traditional Chinese medicine composition is an innovation for treating the Parkinson's disease and has huge economic and social benefits.
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