Integrated bone marrow sample treatment device
Through the design of guide plates and curved baffles, the differences in specific gravity and fluidity are used to separate impurities in bone marrow samples. Combined with dilution with sterile water, the problem of removing impurities from bone marrow samples is solved, and the efficiency and accuracy of sample processing are improved.
Patent Information
- Application Number
- CN202510908670.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-02
- Publication Date
- 2025-09-05
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Existing technologies are unable to effectively remove bone fragments and other solid impurities from bone marrow samples, resulting in complex and ineffective detection and analysis.
The design of guide plates, curved plates and curved baffles is adopted, and the difference in specific gravity and fluidity between bone marrow samples and impurities is utilized to retain and separate impurities in specific areas. Combined with the dilution of the sample with sterile water, the screening and dilution of the bone marrow sample can be achieved.
The method achieves effective removal of impurities in bone marrow samples, improves sample fluidity and the accuracy of detection and analysis, and simplifies the pretreatment process.
Smart Images
Figure CN120591081A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medical sample preprocessing, and more particularly, to an integrated bone marrow sample processing device. Background Art
[0002] Bone marrow examination is one of the commonly used, easily popularized and effective diagnostic examination methods in clinical practice. Bone marrow examination can be used to diagnose hematopoietic system diseases, such as the differential diagnosis of leukemia, the differential diagnosis of various anemias, the diagnosis of multiple myeloma and thrombocytopenia. Bone marrow examination is one of the commonly used, easily popularized and effective diagnostic examination methods in clinical practice. It is divided into bone marrow puncture and bone marrow biopsy. Both of them are to extract a small amount of bone marrow sample for examination. The purpose of bone marrow fluid examination is mainly cell morphology examination, followed by parasitic and bacteriological examination, to assist in the diagnosis of blood diseases, infectious diseases and certain parasitic diseases.
[0003] Current bone marrow samples are usually relatively viscous and have a high cell concentration. During the puncture sampling process, the puncture needle will directly break the bone layer, resulting in the bone marrow sample containing a large amount of bone fragments and impurities, which will affect the subsequent detection and analysis of the bone marrow sample. At the same time, due to the presence of these impurities and small bone fragments, the current pretreatment process of bone marrow samples is complicated and difficult. The current processing methods cannot fully remove bone fragments and other solid impurities in the samples, and the filtration and dilution effects of the bone marrow sample pretreatment need to be further improved. Summary of the Invention
[0004] To overcome the above-mentioned shortcomings of the prior art, an embodiment of the present invention provides an integrated bone marrow sample processing device. By providing a guide plate, an arc-shaped plate, an arc-shaped baffle, and an arc-shaped surface of section A and an arc-shaped surface of section B, the convex design of the arc-shaped surface of section A can fully disperse and separate the bone marrow sample outward. When the sample flows through the connection between the arc-shaped surface of section B and the blocking surface, the bone marrow sample, bone fragments, and other fine solid impurities with higher specific gravity and lower fluidity are retained in the low-lying concave area formed at the connection between the arc-shaped surface of section B and the blocking surface, thereby being separated from the bone marrow sample and temporarily stored, thereby achieving the effect of removing bone fragments and other fine impurities remaining in the bone marrow sample. At the same time, by simultaneously pouring the bone marrow sample into the device along with sterile water, the sample concentration can be diluted while improving the sample fluidity, thereby helping to improve the separation of bone fragments and impurities from the bone marrow sample, thereby solving the problems raised in the above-mentioned background technology.
[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: an integrated bone marrow sample processing device, comprising a guide plate, wherein the guide plate is in an overall semicircular arc shape and is designed to be inclined from top to bottom, and the guide plate is designed to be gradually narrowed from top to bottom. Curved plates are integrally formed on both sides of the guide plate, the curvature of the curved plates is greater than the curvature of the guide plate, and the curved plates are designed to be gradually involute-shaped from top to bottom. A collection cylinder is installed at the bottom end of the guide plate, and a receiving groove is provided inside the collection cylinder. A plurality of curved baffles are equidistantly installed on the inner wall surface of the guide plate from top to bottom, and the shapes of the plurality of curved baffles change as the overall narrowing of the guide plate changes. The arc-shaped baffle includes an arc-shaped surface of section A, an arc-shaped surface of section B is provided on one side of the arc-shaped surface of section A, a blocking surface is provided on the other side of the arc-shaped surface of section B, a flat surface is provided on the side of the blocking surface, and a rounded transition design is adopted between the blocking surface and the flat surface. The convex directions of the arc-shaped surface of section A and the arc-shaped surface of section B are relatively distributed, the trajectory length of the arc-shaped surface of section A is smaller than the trajectory length of the arc-shaped surface of section B, a low-lying concave area is formed at the connection between the arc-shaped surface of section B and the blocking surface, the overall curvature of the blocking surface is greater than the overall curvature of the arc-shaped surface of section B, and the bending direction of the blocking surface is toward one side of the arc-shaped surface of section B.
[0006] In a preferred embodiment, the inner wall surface of the arc-shaped plate maintains close contact with the left and right sides of the arc-shaped baffle, and the arc-shaped plate and the side surfaces of the arc-shaped baffle maintain a fully wrapped design.
[0007] In a preferred embodiment, the expansion directions of the overall shapes of the guide plate and the curved plate are arranged in opposite directions, and the guide plate, the curved plate and the curved baffle are all made of medical-grade sterile materials.
[0008] In a preferred embodiment, the bottom end of the collecting cylinder is flat, a counterweight block may be added to the bottom end of the collecting cylinder, and the bottom surface of the collecting cylinder is configured as a frosted surface.
[0009] In a preferred embodiment, the plurality of arc-shaped baffles are distributed in a stepped manner along the inclined inner wall of the guide plate, and the tail end of the upper arc-shaped baffle is located directly above the head end of the lower arc-shaped baffle.
[0010] Technical effects and advantages of the present invention: The present invention provides a guide plate, an arc plate, an arc baffle, and an arc surface of section A and an arc surface of section B. By utilizing the mutual cooperation of these, the convex design of the arc surface of section A can first disperse the bone marrow sample outward. Then, when the sample flows through the connection between the arc surface of section B and the blocking surface, the bone marrow sample, the bone fragments and other fine solid impurities with different specific gravities and different fluidities are retained in the low-lying concave area formed at the connection between the arc surface of section B and the blocking surface, thereby separating the bone fragments and other fixed impurities with larger specific gravity and poorer fluidity from the bone marrow sample and temporarily storing them, thereby achieving the effect of removing the bone fragments and other fine impurities remaining in the bone marrow sample. At the same time, the bone marrow sample is poured into the device simultaneously with sterile water, which can improve the fluidity of the sample while diluting the sample concentration, and assist in improving the separation effect of bone fragments and impurities from the bone marrow sample, thereby completing the integrated screening and dilution process of the bone marrow sample and further improving the practicality of the device. BRIEF DESCRIPTION OF THE DRAWINGS
[0011] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the three-dimensional structure of the guide plate of the present invention; Figure 3 This is a schematic diagram of the side three-dimensional structure of the guide plate of the present invention; Figure 4 Schematic diagram of the contact surface structure of the arc plate and the arc baffle of the present invention; Figure 5 This is a schematic diagram of the overall three-dimensional structure of the arc baffle of the present invention; Figure 6 It is a schematic diagram of the overall structure of the present invention from multiple angles; Figure 7 It is a schematic diagram of the overall cross-sectional structure of the present invention; Figure 8 Schematic diagram of the half-section structure of the arc-shaped baffle of the present invention; Figure 9 Schematic diagram of the flow direction trajectory of the bone marrow sample on the surface of the arc-shaped baffle according to the present invention.
[0012] The accompanying drawings are marked as follows: 1. guide plate; 2. curved plate; 3. collecting cylinder; 4. receiving tank; 5. curved baffle; 51. curved surface of section A; 52. curved surface of section B; 53. blocking surface; 6. flat surface. DETAILED DESCRIPTION
[0013] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0014] like Figures 1 to 9 The integrated bone marrow sample processing device shown in the figure includes a guide plate 1, which is in the shape of a semicircle as a whole and is designed to be inclined from top to bottom. The guide plate 1 is designed to be gradually narrowed from top to bottom. The shape design of the guide plate 1 can gradually gather the bone fragments when guiding the bone fragments, so as to achieve a rapid screening effect on the sample. The two sides of the guide plate 1 are respectively formed with an arc plate 2, and the curvature of the arc plate 2 is greater than the curvature of the guide plate 1. The arc plate 2 is gradually designed to be involute from top to bottom. The characteristics of the arc plate 2 are set, so that when the bone marrow sample flows through the surface of the arc baffle 5, the arc plate 2 can fully guide and Block, prevent the sample from overflowing from the outside of the arc-shaped baffle 5 during the gathering process, further improve the safety and anti-pollution effect of sample processing, the bottom end of the guide plate 1 is installed with a collecting cylinder 3, the interior of the collecting cylinder 3 is provided with a receiving groove 4, and the inner wall surface of the guide plate 1 is equidistantly installed with multiple arc-shaped baffles 5 from top to bottom. The shapes of the multiple arc-shaped baffles 5 change with the overall narrowing of the guide plate 1. The arrangement of multiple arc-shaped baffles 5 ensures that the bone marrow sample as a whole is screened by the multiple arc-shaped baffles 5 on the inner wall of the guide plate 1 and flows into the collecting cylinder 3 below the guide plate 1 for temporary storage, further improving the processing accuracy of the bone marrow sample, ensuring that impurities in the sample are fully removed, so as to ensure the purity of the sample; The arc-shaped baffle 5 includes an arc-shaped surface 51 of section A, an arc-shaped surface 52 of section B is provided on one side of the arc-shaped surface 51 of section A, and a blocking surface 53 is provided on the other side of the arc-shaped surface 52 of section B. A flat surface 6 is provided on the side of the blocking surface 53, and a rounded transition design is adopted between the blocking surface 53 and the flat surface 6. The convex directions of the arc-shaped surface 51 of section A and the arc-shaped surface 52 of section B are relatively distributed. The trajectory length of the arc-shaped surface 51 of section A is smaller than the trajectory length of the arc-shaped surface 52 of section B. A low-lying concave area is formed at the connection between the arc-shaped surface 52 of section B and the blocking surface 53. The overall curvature of the blocking surface 53 is greater than the overall curvature of the arc-shaped surface 52 of section B. The bending direction of the blocking surface 53 is toward one side of the arc-shaped surface 52 of section B. Through the above arrangement, the arcuate surface 51 of section A protrudes toward the outside of the guide plate 1, and the arcuate surface 52 of section B protrudes toward the inside of the guide plate 1. Thus, the outward convex design of the arcuate surface 51 of section A can fully disperse and separate the bone marrow sample outward, and when the sample flows through the connection between the arcuate surface 52 of section B and the blocking surface 53, the bone marrow sample, bone fragments and other fine solid impurities with different specific gravities and fluidities are retained in the low-lying concave area formed at the connection between the arcuate surface 52 of section B and the blocking surface 53, thereby being separated from the bone marrow sample and temporarily stored, thereby achieving the effect of removing the bone fragments and other fine impurities remaining inside the bone marrow sample.
[0015] The inner wall surface of the arc plate 2 is in close contact with the left and right sides of the arc baffle 5, and the arc plate 2 and the side surfaces of the arc baffle 5 are fully wrapped. The bottom end of the collecting cylinder 3 is flat, and a counterweight block can be added to the bottom end of the collecting cylinder 3. The bottom surface of the collecting cylinder 3 is set to a frosted surface. Through the above-mentioned setting, it is ensured that the weight of one side of the collecting cylinder 3 is greater than the overall weight of the arc baffle 5, thereby effectively ensuring the stability of the overall device during use. At the same time, the bottom end of the collecting cylinder 3 is set to a frosted surface to increase the friction between the collecting cylinder 3 and the workbench, ensuring the stability of the device during use. The arc plate 2 has a certain effect and ensures its normal use. The inner wall surface of the arc plate 2 is in close contact with the left and right sides of the arc baffle 5, and the sides of the arc plate 2 and the arc baffle 5 are fully wrapped. When the arc baffle 5 is retaining the bone marrow sample, no additional sample will overflow on both sides, thereby effectively preventing the sample from contaminating the outside world. At the same time, the curvature of the arc plate 2 itself is greater than the curvature of the guide plate 1, so that when the bone marrow sample flows through the interior of the arc baffle 5, a partial concave space will be formed between the inner wall of the arc plate 2 and the arc baffle 5 to temporarily store the retained bone fragments and impurities.
[0016] Specific reference instructions Figure 3The expansion directions of the overall shape of the guide plate 1 and the curved plate 2 are set in opposite directions. The guide plate 1, the curved plate 2 and the curved baffle 5 are all made of medical-grade sterile materials.
[0017] The specific implementation method is as follows: using the above-mentioned setting, it can be ensured that the guide plate 1 will gradually gather the bone marrow sample flowing from top to bottom, and at the same time, the extended setting of the arc plate 2 is adopted to fully ensure the diversion and blocking of the sample, preventing the sample from overflowing from the outside of the arc baffle 5 during the gathering process, further improving the practicality of the device. At the same time, the use of medical-grade sterile materials can ensure that the bone marrow sample will not be additionally contaminated when the device is used, further improving the safety of the device.
[0018] Specific reference instructions Figure 6-Figure 7 The multiple arc-shaped baffles 5 are distributed in a stepped manner along the inclined inner wall of the guide plate 1 , and the tail end of the upper arc-shaped baffle 5 is located directly above the head end of the lower arc-shaped baffle 5 .
[0019] The specific implementation method is as follows: by utilizing the position setting of the above-mentioned multiple curved baffles 5, it can be ensured that the bone marrow sample flowing out from the previous curved baffle 5 can flow smoothly to the top of the head end of the next curved baffle 5, thereby ensuring that the sample can be fully screened and diverted and sorted when flowing through the surface of each curved baffle 5, thereby blocking bone fragments and other fine impurities and allowing the sample to flow normally through the surface of multiple curved baffles 5, thereby achieving the effect of multi-layer screening and processing. At the same time, the bone marrow sample is poured in simultaneously with sterile water, which can improve the fluidity of the sample while diluting the concentration of the bone marrow sample, and assist in improving the separation effect of bone fragments and impurities from the bone marrow sample, thereby completing the integrated screening and dilution processing process of the bone marrow sample.
[0020] Working principle of the present invention: Step 1: First, the operator assembles the various components of the device normally, then uses the device normally, and places the device on the workbench.
[0021] Step 2: First, the operator pours the bone marrow sample along with a small amount of sterile water from the top of the guide plate 1. At this time, the bone marrow sample gradually flows from top to bottom along the inclined inner wall of the guide plate 1 under the action of the flow of sterile water and its own gravity, and at the same time gradually flows into the surface of the arc-shaped baffle 5, and flows downward along the surface of the arc-shaped surface 51 of section A. The convex design of the arc-shaped surface 51 of section A can fully disperse the bone marrow sample outward and flow toward the surface of the arc-shaped surface 52 of section B. When flowing through the connection between the arc-shaped surface 52 of section B and the blocking surface 53, due to the difference in specific gravity and fluidity between the bone marrow sample and the bone fragments and other fine solid impurities, the bone fragments and other fixed impurities with larger specific gravity and poorer fluidity are retained in the low-lying concave area formed at the connection between the arc-shaped surface 52 of section B and the blocking surface 53. , thereby being separated from the bone marrow sample and temporarily stored, while the bone marrow sample with lighter specific gravity and better fluidity will flow smoothly through the top of the blocking surface 53 with the flow of water and its own flow inertia force, and fall quickly along the flat surface 6 on one side of the blocking surface 53, so as to facilitate the next round of screening operation on the surface of the next arc-shaped baffle 5, ensuring that the entire bone marrow sample is screened and processed by the multiple arc-shaped baffles 5 on the inner wall of the guide plate 1, and then flows into the collection cylinder 3 below the guide plate 1 for collection, so as to facilitate the subsequent collection operation of the processed bone marrow sample. At the same time, after use, the inside of the guide plate 1 and the arc-shaped baffle 5 can be cleaned with running water to ensure that the impurities such as bone fragments trapped inside are flushed out, so as to facilitate subsequent use. Finally, the device completes the process of integrated multiple screening and processing of bone marrow samples.
[0022] Step 3: First, the operator shuts down the device normally, then checks whether the fixation between the various components of the device is normal, and then replaces and repairs the aging and severely worn parts inside the device.
[0023] Finally, a few points should be explained: First, in the description of this application, it should be noted that, unless otherwise specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense, and may refer to mechanical or electrical connections, internal communication between two components, or direct connection. "Up," "down," "left," and "right" are only used to indicate relative positional relationships. When the absolute positions of the objects being described change, the relative positional relationships may also change. Secondly: The drawings of the embodiments disclosed in the present invention only involve structures related to the embodiments disclosed in the present invention. Other structures may refer to conventional designs. The same embodiment and different embodiments of the present invention may be combined with each other without conflict. Finally: The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.
Claims
1. An integrated bone marrow sample processing device, characterized by: The invention comprises a guide plate, wherein the guide plate is in an overall semicircular shape, and the guide plate is designed to be inclined from top to bottom, and the guide plate is designed to be gradually narrowed from top to bottom. Arc plates are respectively formed integrally on both sides of the guide plate, and the curvature of the arc plates is greater than the curvature of the guide plate. The arc plates are designed to be gradually involute from top to bottom. A collecting cylinder is installed at the bottom end of the guide plate, and a receiving groove is opened inside the collecting cylinder. A plurality of arc baffles are installed on the inner wall surface of the guide plate at equal intervals from top to bottom, and the shapes of the plurality of arc baffles change as the overall narrowing of the guide plate changes. The arc-shaped baffle includes an arc-shaped surface of section A, an arc-shaped surface of section B is provided on one side of the arc-shaped surface of section A, a blocking surface is provided on the other side of the arc-shaped surface of section B, a flat surface is provided on the side of the blocking surface, and a rounded transition design is adopted between the blocking surface and the flat surface. The convex directions of the arc-shaped surface of section A and the arc-shaped surface of section B are relatively distributed, the trajectory length of the arc-shaped surface of section A is smaller than the trajectory length of the arc-shaped surface of section B, a low-lying concave area is formed at the connection between the arc-shaped surface of section B and the blocking surface, the overall curvature of the blocking surface is greater than the overall curvature of the arc-shaped surface of section B, and the bending direction of the blocking surface is toward one side of the arc-shaped surface of section B.
2. The integrated bone marrow sample processing device according to claim 1, characterized in that: The inner wall surface of the arc-shaped plate is in close contact with the left and right sides of the arc-shaped baffle, and the arc-shaped plate and the side surfaces of the arc-shaped baffle are in a fully wrapped design.
3. The integrated bone marrow sample processing device according to claim 1, characterized in that: The expansion directions of the guide plate and the curved plate are arranged in opposite directions. The guide plate, the curved plate and the curved baffle are all made of medical-grade sterile materials.
4. The integrated bone marrow sample processing device according to claim 1, characterized in that: The bottom end of the collecting cylinder is flat, a counterweight block can be added to the bottom end of the collecting cylinder, and the bottom surface of the collecting cylinder is set to be a frosted surface.
5. The integrated bone marrow sample processing device according to claim 1, characterized in that: The plurality of arc-shaped baffles are distributed in a stepped manner along the inclined inner wall of the guide plate, and the tail end of the upper arc-shaped baffle is located directly above the head end of the lower arc-shaped baffle.