Electric field application control method and system for multi-focus dynamic non-invasive non-contact treatment device

Abstract

The invention discloses an electric field application control method and system for a multi-focus dynamic non-invasive non-contact treatment device, and the method comprises the following steps: S1, collecting a tumor image of a patient, segmenting tumor focuses, determining the number and size of the focuses, and executing the step S2 if there are multiple focuses; s2, determining the intensity and frequency of electrode plates and electric fields acting on different focuses according to the volume of the tumor focuses; s3, determining an output voltage phase of the electrode plate based on an asymmetric phase modulation model; and S4, carrying out field intensity regulation and control on the electrode array by adopting a time division energy distribution strategy. By adopting the technical scheme, multi-focus phase compensation is established, the field intensity balance is realized by adjusting the phase difference of the electrode array, and the field intensity is distributed according to the volume weight to adapt to the tumor morphological change.

Description

Technical Field

[0001] The present invention belongs to the technical field of tumor electric field therapy, and relates to an electric field application control method and system for a multi-lesion dynamic non-invasive non-contact therapy device. Background Art

[0002] Malignant tumors seriously endanger human life and health. Ablation therapy based on irreversible electroporation, which has emerged in recent years, is a new type of non-thermal ablation technology. This technology uses high-voltage pulsed electric fields to destroy cell membranes, causing irreversible perforation, destroying cell homeostasis, and ultimately leading to cell death. Compared with thermal ablation technology, its ablation boundaries are clear and can effectively avoid damage to important structures such as blood vessels, bile ducts and nerves, allowing more cancer patients to have the opportunity to be treated and achieving significant clinical results.

[0003] However, the prior art still has the following defects:

[0004] Single lesion limitation: Traditional electric field therapy equipment is only designed for single lesions. Multi-lesion treatment requires multiple positioning, which is inefficient.

[0005] Field strength imbalance: The electric fields of multiple lesions interfere with each other, and the intensity deviation is >30%;

[0006] Static electrode layout: Fixed electrode array cannot adapt to changes in tumor morphology, leading to cold / hot spot problems. Summary of the Invention

[0007] The purpose of the present invention is to provide a method and system for controlling electric field application of a multi-lesion dynamic non-invasive non-contact treatment device to achieve field intensity balance and adapt to changes in tumor morphology.

[0008] In order to achieve the above-mentioned object, the basic scheme of the present invention is: a method for controlling electric field application of a multi-lesion dynamic non-invasive non-contact treatment device, comprising the following steps:

[0009] S1, collects the patient's tumor image and inputs it into the convolutional neural network to segment the tumor boundary, obtain segmented tumor lesions, and determine the number and volume of lesions;

[0010] S2, based on the volume of the tumor lesion, determines the electrode plates, electric field strength and frequency acting on different lesions;

[0011] S3, based on the asymmetric phase modulation model, determines the output voltage phase of the electrode plate;

[0012] S4, a time-division energy allocation strategy is used to perform field intensity control on the electrode array.

[0013] The working principle and beneficial effects of this basic solution are as follows: Based on the asymmetric phase modulation model (APM model), this technical solution establishes a phase difference compensation formula to solve the problem of electric field intensity imbalance in multiple lesions, with a synchronous field intensity error of less than 5%. Based on CT / MRI imaging data, the electrode array arrangement scheme is generated in real time to achieve precise positioning of multiple lesions.

[0014] This method utilizes a time-fractionated energy allocation strategy, weighting field strength distribution by tumor volume, increasing treatment efficiency by 42%. Through adaptive electric field control, this method breaks through the limitations of traditional single-lesion treatment and is suitable for treating multifocal tumors such as pancreatic cancer and lung cancer.

[0015] Furthermore, the patient's tumor image is collected and input into the convolutional neural network to segment the tumor boundary. The method for obtaining the segmented tumor lesions is as follows:

[0016] Normalize the grayscale of the tumor image and perform noise reduction;

[0017] The tumor image is input into the DU-Net model to obtain segmented tumor lesions and determine the number of tumor lesions;

[0018] Tumor lesion volume = number of voxels × voxel volume.

[0019] Segmenting tumor lesions facilitates targeted treatment.

[0020] Furthermore, according to the volume of the tumor lesion, the electrode plates acting on different lesions are determined, specifically:

[0021] S31, sorting the tumor lesions by volume from largest to smallest, and selecting the locations of the top M tumor lesions, where M is the number of movable electrode plate arrays;

[0022] S32, let the tumor number t = 1, and establish a working sequence for the mobile electrode plate sub-array and the fixed electrode plate sub-array;

[0023] S32, if t = M, then exit; otherwise, project the t-th tumor lesion onto different fixed electrode plate sub-arrays, and select the fixed electrode plate sub-array corresponding to the largest projected area as the fixed electrode plate sub-array to be activated;

[0024] Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor lesion;

[0025] The fixed electrode plate sub-array is on one side of the tumor lesion, and the movable electrode plate sub-array is moved to the other side of the corresponding tumor lesion, so that the center of the movable electrode plate sub-array moves to the straight line and is perpendicular to the straight line. The movable electrode plate sub-array and the fixed electrode plate sub-array to be turned on are the electrode plate arrays that need to be turned on;

[0026] S33, let t=t+1, delete the serial numbers of the movable electrode plate subarray and the fixed electrode plate subarray selected in step S32 from the working sequence of the movable electrode plate subarray and the fixed electrode plate subarray, and return to step S32.

[0027] The electrode plates acting on different lesions are determined according to the volume of the tumor lesions.

[0028] Furthermore, the intensity and frequency of the electric field of the electrode plate acting on each lesion are determined. The specific steps are as follows:

[0029] Get the distance d between the i-th electrode plate and the center of the tumor of lesion j ij (x);

[0030] Determine the electric field strength E of the i-th electrode plate at the tumor center x of the lesion j ij (x), using the impedance tomography technology of the tumor area to obtain the conductivity σ of the tumor center of the lesion j j (x):

[0031]

[0032] Among them, V ij (x,φ i ) is the voltage of the i-th electrode plate at the center of the tumor area x of the lesion j, φ i is the phase of the output voltage of the i-th electrode plate, σ0 is the conductivity of the normal tissue around the tumor area;

[0033] Determine the desired electric field strength E0(x) according to the treatment purpose;

[0034] Adjust the voltage and phase of each electrode plate to solve the objective function The electric field is focused on the tumor area, A1 is the tumor area;

[0035] Determine the characteristic frequency f of the tumor in lesion j tj ,for:

[0036]

[0037] Among them, σ j is the conductivity of the tumor, that is, the conductivity σ of the tumor center of lesion j j (x); ε is the dielectric constant of the tumor, which can be determined in advance based on the tumor type;

[0038] According to the characteristic frequency f of the tumor tj During the treatment process, the working frequency of the electrode array and the duration of treatment need to be adjusted according to different goals. Suppose the working frequency of the electrode array is f ele , set it near the resonant frequency of the tumor:

[0039] f ele =f tj ±Δf

[0040] Wherein, Δf is the preset frequency range.

[0041] Determining the intensity and frequency of the electric field of the electrode plate acting on each lesion is beneficial for subsequent control of the electrode plate.

[0042] Furthermore, based on the asymmetric phase modulation model, the electrode plate output voltage phase φ is determined. i for:

[0043]

[0044] Where φ0 is the initial phase of the output voltage of the i-th electrode plate (can be 0); λ is the wavelength of the electric field electromagnetic wave; d i is the distance between the i-th electrode plate and its corresponding lesion.

[0045] The multi-lesion phase difference compensation parameters are calculated based on the asymmetric phase modulation model (APM Model) to solve the problem of multi-lesion electric field intensity imbalance, and the synchronization field intensity error is <5%.

[0046] Furthermore, the time-segmented energy allocation strategy is used to perform differentiated field intensity control on multiple lesions:

[0047] S61, if the number of tumors is greater than M, sort the tumor lesions from largest to smallest, starting from the M+1th to the 2Mth, and screen the locations of the top M tumor lesions, where M is the number of movable electrode plate arrays;

[0048] S62, let the tumor number t = 1, and establish a working sequence for the mobile electrode plate sub-array and the fixed electrode plate sub-array;

[0049] S63, if t=2M, then exit; otherwise, project the t-th tumor lesion onto different fixed electrode plate sub-arrays, and select the fixed electrode plate sub-array corresponding to the largest projected area as the fixed electrode plate sub-array to be activated;

[0050] S64, let t = t + 1, delete the sequence numbers of the movable electrode plate subarray and the fixed electrode plate subarray selected in step S63 from the working sequence of the movable electrode plate subarray and the fixed electrode plate subarray, and return to step S63;

[0051] After processing, one electrode plate will correspond to one or two lesions. When corresponding to two lesions, a time-division energy allocation strategy is adopted to perform differentiated field intensity control on different lesions corresponding to the same electrode plate:

[0052] The same electrode plate treatment cycle is divided into N time slots, and the corresponding tumor volume V ij Calculate the weight coefficient w ij :

[0053]

[0054] In each time slot, a field strength E is applied to the tumor lesion j. ij :

[0055]

[0056] Among them, V ij is the tumor volume of the jth tumor corresponding to the i-th electrode plate, E max is the maximum field strength applied by the i-th electrode plate to the tumor lesion.

[0057] By utilizing a time-fractionated energy allocation strategy and weighted distribution of field strength according to tumor volume, treatment efficiency was increased by 42%.

[0058] Furthermore, the electric field distribution is corrected in real time using impedance tomography;

[0059] Via electrostatic force feedback: Maintain non-contact electrode spacing.

[0060] Correct the electric field distribution in real time to prevent imbalance of field strength in multiple lesions and optimize the treatment effect.

[0061] The present invention also provides an electric field application control system for a multi-lesion dynamic non-invasive non-contact treatment device, comprising an image acquisition module and a processing module, wherein the image acquisition module is used to acquire tumor images of the patient and transmit the images to the processing module;

[0062] The processing module executes the method of the present invention to perform differentiated field intensity control on the electrode plate array.

[0063] This system is based on dynamic, non-invasive, and contactless adaptive electric field technology to achieve spatiotemporal synchronous treatment of multiple lesions.

[0064] Furthermore, the electrode plate array includes a plurality of fixed electrode plate sub-arrays and a plurality of movable electrode plate sub-arrays;

[0065] Each electrode plate sub-array includes a plurality of independently operable electrode plates. During treatment, a fixed electrode plate sub-array is determined to form an electrode plate array pair with the movable electrode plate sub-array.

[0066] The number of electrode plates on the fixed electrode plate subarray and the number of electrode plates on the movable electrode plate subarray are the same;

[0067] During treatment, each tumor lesion is projected onto a different fixed electrode plate sub-array, and the fixed electrode plate sub-array corresponding to the largest projected area is selected as the fixed electrode plate sub-array to be activated;

[0068] Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor lesion;

[0069] The fixed electrode plate sub-array is on one side of the tumor lesion, and the movable electrode plate sub-array is moved to the other side of the corresponding tumor lesion, so that the center of the movable electrode plate sub-array moves to the straight line and is perpendicular to the straight line. The movable electrode plate sub-array and the fixed electrode plate sub-array to be turned on are the electrode plate arrays that need to be turned on;

[0070] The electrode plates on the movable electrode plate sub-array are matched in pairs with the electrode plates on the fixed electrode plate array to be turned on, and each electrode pair forms two poles of the alternating electric field.

[0071] The electrode plate can adopt a nine-square grid structure, and the fixed electrode plate sub-array and the movable electrode plate sub-array are coordinated to realize flexible regulation of the electrode plate array.

[0072] Furthermore, the electrode plate array includes a plurality of fixed electrode plate sub-arrays and a movable electrode plate sub-array;

[0073] Each electrode plate sub-array includes a plurality of independently operable electrode plates. During treatment, a fixed electrode plate sub-array is determined to form an electrode plate array pair with the movable electrode plate sub-array.

[0074] The number of electrode plates on the fixed electrode plate subarray and the number of electrode plates on the movable electrode plate subarray are the same;

[0075] During treatment, the tumor is projected onto different fixed electrode plate sub-arrays, and the fixed electrode plate sub-array corresponding to the largest projected area is selected as the fixed electrode plate sub-array to be activated;

[0076] Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor;

[0077] The fixed electrode plate subarray is on one side of the tumor, and the electrode plates on each movable electrode plate subarray can independently change their orientation so that the center of the movable electrode plate subarray moves to the straight line and is perpendicular to the straight line;

[0078] The electrode plates on the movable electrode plate sub-array are matched in pairs with the electrode plates on the fixed electrode sub-plate array to be turned on, and each electrode pair forms two poles of the alternating electric field.

[0079] The electrode plate array has a simple structure and is easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0080] Figure 1 It is a flow chart of the electric field application control method of the multi-lesion dynamic non-invasive non-contact treatment device of the present invention. DETAILED DESCRIPTION

[0081] The following describes embodiments of the present invention in detail. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended only to explain the present invention and are not to be construed as limiting the present invention.

[0082] In the description of the present invention, it should be understood that the terms "longitudinal", "transverse", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0083] In the description of the present invention, unless otherwise specified and limited, it should be noted that the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a mechanical connection or an electrical connection, or it can be the internal communication between two components. It can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to the specific circumstances.

[0084] The present invention discloses a method for controlling the electric field application of a multi-lesion dynamic non-invasive non-contact treatment device. By adaptively regulating the electric field, the method breaks through the limitations of traditional single-lesion treatment and is applicable to the treatment of multi-lesion tumors such as pancreatic cancer and lung cancer. Figure 1 As shown, the electric field application control method of the multi-lesion dynamic non-invasive non-contact treatment device includes the following steps:

[0085] S1. Capture a patient's tumor image and input it into a convolutional neural network to segment the tumor boundary, obtain segmented tumor lesions, and determine the number and volume of lesions. If the lesion is a single lesion, the specific steps are described in detail in the applicant's patent application entitled "A Non-Invasive High-Voltage Alternating Electric Field Tumor Treatment System and Method" and are not repeated here. This patent application is directed to a method for controlling electric field application in a dynamic, non-invasive, and non-contact treatment device for multiple lesions.

[0086] S2, based on the volume of the tumor lesion, determines the electrode plates, electric field strength and frequency acting on different lesions;

[0087] S3, based on the asymmetric phase modulation model (APM Model), determine the output voltage phase of the electrode plate;

[0088] S4 uses a time-fractionated energy allocation strategy, weighting field strength by volume and controlling the field intensity of the electrode array. This weighted distribution of field strength by tumor volume improves treatment efficiency by 42%, keeping skin temperature rise within a ΔT < 1.5°C.

[0089] In a preferred embodiment of the present invention, a method for collecting a patient's tumor image and inputting it into a convolutional neural network to segment the tumor boundary and obtain segmented tumor lesions is as follows:

[0090] Normalize the grayscale of the tumor image and perform noise reduction;

[0091] The tumor image is input into the DU-Net model to obtain segmented tumor lesions and determine the number of tumor lesions;

[0092] Tumor lesion volume = number of voxels × voxel volume.

[0093] In a preferred embodiment of the present invention, the electrode plates acting on different tumor lesions are determined according to the volume of the tumor lesion, specifically:

[0094] S31, sorting the tumor lesions by volume from largest to smallest, and selecting the locations of the top M tumor lesions, where M is the number of movable electrode plate arrays;

[0095] S32, let the tumor number t = 1, and establish a working sequence for the mobile electrode plate sub-array and the fixed electrode plate sub-array;

[0096] S32, if t = M, then exit; otherwise, project the t-th tumor lesion onto different fixed electrode plate sub-arrays, and select the fixed electrode plate sub-array corresponding to the largest projected area as the fixed electrode plate sub-array to be activated;

[0097] Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor lesion;

[0098] The fixed electrode plate sub-array is on one side of the tumor lesion, and the movable electrode plate sub-array is moved to the other side of the corresponding tumor lesion, so that the center of the movable electrode plate sub-array moves to the straight line and is perpendicular to the straight line. The movable electrode plate sub-array and the fixed electrode plate sub-array to be turned on are the electrode plate arrays that need to be turned on;

[0099] S33, let t=t+1, delete the serial numbers of the movable electrode plate subarray and the fixed electrode plate subarray selected in step S32 from the working sequence of the movable electrode plate subarray and the fixed electrode plate subarray, and return to step S32.

[0100] In a preferred embodiment of the present invention, the intensity and frequency of the electric field of the electrode plate acting on each lesion are determined by the following specific steps:

[0101] Get the distance d between the i-th electrode plate and the center of the tumor of lesion j ij (x);

[0102] Determine the electric field strength E of the i-th electrode plate at the tumor center x of the lesion j ij (x), using the impedance tomography technology of the tumor area to obtain the conductivity σ of the tumor center of the lesion j j (x):

[0103]

[0104] Among them, V ij (x,φ i ) is the voltage of the i-th electrode plate at the center of the tumor area x of the lesion j, φ i is the phase of the output voltage of the i-th electrode plate, σ0 is the conductivity of the normal tissue around the tumor area;

[0105] The expected electric field strength E0(x) is determined according to the treatment purpose. When used for the treatment of cell apoptosis (such as smaller tumors or shallow tumors), the amplitude of the expected electric field strength is set to several tens of V / cm; when used to enhance the permeability of the cell membrane (such as electroporation therapy), the amplitude of the expected electric field strength is set to 100V / cm to 1000V / cm; when used for the treatment of tumor necrosis and deep tumors (such as invasive tumor treatment), the amplitude of the expected electric field strength is set to above 1000V / cm. The specific setting can be based on actual conditions.

[0106] Adjust the voltage and phase of each electrode plate to solve the objective function The electric field is focused on the tumor area, A1 is the tumor area;

[0107] Determine the characteristic frequency f of the tumor in lesion j tj ,for:

[0108]

[0109] Among them, σ j is the conductivity of the tumor, that is, the conductivity σ of the tumor center of lesion j j (x); ε is the dielectric constant of the tumor, which can be determined in advance based on the tumor type;

[0110] According to the characteristic frequency f of the tumor tj During the treatment process, the working frequency of the electrode array and the duration of treatment need to be adjusted according to different goals. Suppose the working frequency of the electrode array is f ele , set it near the resonant frequency of the tumor:

[0111] f ele =f tj ±Δf

[0112] Wherein, Δf is the preset frequency range.

[0113] Preferably, the method for determining the tumor center is specifically:

[0114] Use CT to obtain the morphology and location of the tumor;

[0115] Use computer-assisted image processing technology to perform three-dimensional reconstruction of CT images;

[0116] Determine the centroid of the 3D shape of the tumor: discretize the 3D model of the tumor into small volume units, calculate the centroids of all small volume units and average them.

[0117] In a preferred embodiment of the present invention, based on the asymmetric phase modulation model, the output voltage phase φ of the electrode plate is determined. i for:

[0118]

[0119] Where φ0 is the initial phase of the output voltage of the i-th electrode plate (can be 0); λ is the wavelength of the electric field electromagnetic wave; d i is the distance between the i-th electrode plate and its corresponding lesion.

[0120] A phase difference compensation formula was established to solve the problem of imbalanced electric field strength in multiple lesions, and the synchronous field strength error was <5%.

[0121] When three lesions were treated simultaneously, the standard deviation of the field strength decreased from 32.7% to 4.8% (p<0.01).

[0122] In a preferred embodiment of the present invention, a method for performing differentiated field intensity control on multiple lesions using a time-segmented energy allocation strategy is as follows:

[0123] S61, if the number of tumors is greater than M, sort the tumor lesions from largest to smallest, starting from the M+1th to the 2Mth, and screen the locations of the top M tumor lesions, where M is the number of movable electrode plate arrays;

[0124] S62, let the tumor number t = 1, and establish a working sequence for the mobile electrode plate sub-array and the fixed electrode plate sub-array;

[0125] S63, if t=2M, then exit; otherwise, project the t-th tumor lesion onto different fixed electrode plate sub-arrays, and select the fixed electrode plate sub-array corresponding to the largest projected area as the fixed electrode plate sub-array to be activated;

[0126] S64, let t = t + 1, delete the sequence numbers of the movable electrode plate subarray and the fixed electrode plate subarray selected in step S63 from the working sequence of the movable electrode plate subarray and the fixed electrode plate subarray, and return to step S63;

[0127] After processing, one electrode plate will correspond to one or two lesions. When corresponding to two lesions, a time-division energy allocation strategy is adopted to perform differentiated field intensity control on different lesions corresponding to the same electrode plate:

[0128] The same electrode plate treatment cycle is divided into N time slots, and the corresponding tumor volume V ij Calculate the weight coefficient w ij :

[0129]

[0130] In each time slot, a field strength E is applied to the tumor lesion j. ij :

[0131]

[0132] Among them, V ij is the tumor volume of the jth tumor corresponding to the i-th electrode plate, E max is the maximum expected electric field amplitude applied by the i-th electrode plate to the tumor lesion.

[0133] The present invention also provides an electric field application control system for a multi-lesion dynamic non-invasive, contactless treatment device, comprising an image acquisition module and a processing module. The image acquisition module is configured to capture images of a patient's tumor and transmit them to the processing module. The processing module executes the method described herein to perform differentiated field intensity control on the electrode plate array.

[0134] This system is based on dynamic, non-invasive, and contactless adaptive electric field technology to achieve spatiotemporal synchronous treatment of multiple lesions.

[0135] In a preferred embodiment of the present invention, the electrode plate array includes a plurality of fixed electrode plate sub-arrays and a plurality of movable electrode plate sub-arrays;

[0136] Each electrode plate sub-array includes a plurality of independently operable electrode plates. During treatment, a fixed electrode plate sub-array is determined to form an electrode plate array pair with the movable electrode plate sub-array.

[0137] The number of electrode plates on the fixed electrode plate subarray and the number of electrode plates on the movable electrode plate subarray are the same;

[0138] During treatment, each tumor lesion is projected onto a different fixed electrode plate sub-array, and the fixed electrode plate sub-array corresponding to the largest projected area is selected as the fixed electrode plate sub-array to be activated;

[0139] Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor lesion;

[0140] The fixed electrode plate sub-array is on one side of the tumor lesion, and the movable electrode plate sub-array is moved to the other side of the corresponding tumor lesion, so that the center of the movable electrode plate sub-array moves to the straight line and is perpendicular to the straight line. The movable electrode plate sub-array and the fixed electrode plate sub-array to be turned on are the electrode plate arrays that need to be turned on;

[0141] The electrode plates on the movable electrode plate sub-array are matched in pairs with the electrode plates on the fixed electrode sub-plate array to be turned on, and each electrode pair forms two poles of the alternating electric field.

[0142] The electrode plate can adopt a nine-square grid structure, and the fixed electrode plate sub-array and the movable electrode plate sub-array are coordinated to realize flexible regulation of the electrode plate array.

[0143] In another preferred embodiment of the present invention, the electrode plate array includes a plurality of fixed electrode plate sub-arrays and a movable electrode plate sub-array;

[0144] Each electrode plate sub-array includes a plurality of independently operable electrode plates. During treatment, a fixed electrode plate sub-array is determined to form an electrode plate array pair with the movable electrode plate sub-array.

[0145] The number of electrode plates on the fixed electrode plate subarray and the number of electrode plates on the movable electrode plate subarray are the same;

[0146] During treatment, the tumor is projected onto different fixed electrode plate sub-arrays, and the fixed electrode plate sub-array corresponding to the largest projected area is selected as the fixed electrode plate sub-array to be activated;

[0147] Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor;

[0148] The fixed electrode plate subarray is on one side of the tumor, and the electrode plates on each movable electrode plate subarray can independently change their orientation so that the center of the movable electrode plate subarray moves to the straight line and is perpendicular to the straight line;

[0149] The electrode plates on the movable electrode plate sub-array are matched in pairs with the electrode plates on the fixed electrode sub-plate array to be turned on, and each electrode pair forms two poles of the alternating electric field.

[0150] The present invention is based on an asymmetric phase modulation model:

[0151] Establish a multi-lesion phase compensation formula to achieve field intensity balance by adjusting the phase difference of the electrode array;

[0152] Experimental data: When three lesions were treated simultaneously, the standard deviation of the field strength decreased from 32.7% to 4.8% (p<0.01).

[0153] Using dynamic topology reconstruction algorithm:

[0154] Segment CT / MRI images based on the U-Net network and output the three-dimensional coordinates of the lesion;

[0155] Energy allocation based on time division:

[0156] Allocation of field strength by volume weight: The total treatment time for multifocal pancreatic cancer was shortened by 42% (n=30 cases).

[0157] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0158] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to the embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the claims and their equivalents.

Claims

1. A method for controlling electric field application of a multi-lesion dynamic non-invasive non-contact treatment device, characterized in that: The steps include: S1, collects the patient's tumor image and inputs it into the convolutional neural network to segment the tumor boundary, obtain segmented tumor lesions, and determine the number and volume of lesions; S2, based on the volume of the tumor lesion, determines the electrode plates, electric field strength and frequency acting on different lesions; S3, based on the asymmetric phase modulation model, determines the output voltage phase of the electrode plate; S4, a time-division energy allocation strategy is used to perform field intensity control on the electrode array.

2. The electric field application control method of the multi-lesion dynamic non-invasive non-contact treatment device according to claim 1, characterized in that: The method for collecting the patient's tumor image and inputting it into the convolutional neural network to segment the tumor boundary and obtain the segmented tumor lesions is as follows: Normalize the grayscale of the tumor image and perform noise reduction; The tumor image is input into the DU-Net model to obtain segmented tumor lesions and determine the number of tumor lesions; Tumor lesion volume = number of voxels × voxel volume.

3. The electric field application control method of the multi-lesion dynamic non-invasive non-contact treatment device according to claim 1, characterized in that: According to the volume of the tumor lesion, the electrode plates acting on different lesions are determined, specifically: S31, sorting the tumor lesions by volume from largest to smallest, and selecting the locations of the top M tumor lesions, where M is the number of movable electrode plate arrays; S32, let the tumor number t = 1, and establish a working sequence for the mobile electrode plate sub-array and the fixed electrode plate sub-array; S32, if t = M, then exit; otherwise, project the t-th tumor lesion onto different fixed electrode plate sub-arrays, and select the fixed electrode plate sub-array corresponding to the largest projected area as the fixed electrode plate sub-array to be activated; Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor lesion; The fixed electrode plate sub-array is on one side of the tumor lesion, and the movable electrode plate sub-array is moved to the other side of the corresponding tumor lesion, so that the center of the movable electrode plate sub-array moves to the straight line and is perpendicular to the straight line. The movable electrode plate sub-array and the fixed electrode plate sub-array to be turned on are the electrode plate arrays that need to be turned on; S33, let t=t+1, delete the serial numbers of the movable electrode plate subarray and the fixed electrode plate subarray selected in step S32 from the working sequence of the movable electrode plate subarray and the fixed electrode plate subarray, and return to step S32.

4. The electric field application control method for a multi-lesion dynamic non-invasive non-contact treatment device according to claim 1, characterized in that: Determine the strength and frequency of the electric field applied to each lesion by the electrode pads. The specific steps are as follows: Get the distance d between the i-th electrode plate and the center of the tumor of lesion j ij (x); Determine the electric field strength E of the i-th electrode plate at the tumor center x of the lesion j ij (x), using the impedance tomography technology of the tumor area to obtain the conductivity σ of the tumor center of the lesion j j (x): Among them, V ij (x,φ i ) is the voltage of the i-th electrode plate at the center of the tumor area x of the lesion j, φ i is the phase of the output voltage of the i-th electrode plate, σ0 is the conductivity of the normal tissue around the tumor area; Determine the desired electric field strength E0(x) according to the treatment purpose; Adjust the voltage and phase of each electrode plate to solve the objective function The electric field is focused on the tumor area, A1 is the tumor area; Determine the characteristic frequency f of the tumor in lesion j tj ,for: Among them, σ j is the conductivity of the tumor, that is, the conductivity σ of the tumor center of lesion j j (x); ε is the dielectric constant of the tumor, which can be determined in advance based on the tumor type; According to the characteristic frequency f of the tumor tj During the treatment process, the working frequency of the electrode array and the duration of treatment need to be adjusted according to different goals. Suppose the working frequency of the electrode array is f ele , set it near the resonant frequency of the tumor: f ele =f tj ±Δf Wherein, Δf is the preset frequency range.

5. The electric field application control method of the multi-lesion dynamic non-invasive non-contact treatment device according to claim 1, characterized in that: Based on the asymmetric phase modulation model, the electrode plate output voltage phase φ is determined i for: Where φ0 is the initial phase of the output voltage of the i-th electrode plate; λ is the wavelength of the electric field electromagnetic wave; d i is the distance between the i-th electrode plate and its corresponding lesion.

6. The electric field application control method for a multi-lesion dynamic non-invasive non-contact treatment device according to claim 3, characterized in that: The method of using time-segmented energy allocation strategy to perform differentiated field intensity control on multiple lesions is as follows: S61, if the number of tumors is greater than M, sort the tumor lesions from largest to smallest, starting from the M+1th to the 2Mth, and screen the locations of the top M tumor lesions, where M is the number of movable electrode plate arrays; S62, let the tumor number t = 1, and establish a working sequence for the mobile electrode plate sub-array and the fixed electrode plate sub-array; S63, if t=2M, then exit; otherwise, project the t-th tumor lesion onto different fixed electrode plate sub-arrays, and select the fixed electrode plate sub-array corresponding to the largest projected area as the fixed electrode plate sub-array to be activated; S64, let t = t + 1, delete the sequence numbers of the movable electrode plate subarray and the fixed electrode plate subarray selected in step S63 from the working sequence of the movable electrode plate subarray and the fixed electrode plate subarray, and return to step S63; After processing, one electrode plate will correspond to one or two lesions. When corresponding to two lesions, a time-division energy allocation strategy is adopted to perform differentiated field intensity control on different lesions corresponding to the same electrode plate: The treatment cycle of the same electrode plate is divided into N time slots, and the corresponding tumor volume V ij Calculate the weight coefficient w ij : In each time slot, a field strength E is applied to the tumor lesion j. ij : Among them, V ij is the tumor volume of the jth tumor corresponding to the i-th electrode plate; E max is the maximum field strength applied by the i-th electrode plate to the tumor lesion.

7. An electric field application control system for a multi-lesion dynamic non-invasive non-contact treatment device, characterized in that: It includes an image acquisition module and a processing module, wherein the image acquisition module is used to acquire the patient's tumor image and transmit it to the processing module; The processing module executes the method according to any one of claims 1 to 6 to perform differentiated field intensity control on the electrode plate array.

8. The electric field application control system of the multi-lesion dynamic non-invasive non-contact treatment device according to claim 7, characterized in that: The electrode plate array includes a plurality of fixed electrode plate sub-arrays and a plurality of movable electrode plate sub-arrays; Each electrode plate sub-array includes a plurality of independently operable electrode plates. During treatment, a fixed electrode plate sub-array is determined to form an electrode plate array pair with the movable electrode plate sub-array. The number of electrode plates on the fixed electrode plate subarray and the number of electrode plates on the movable electrode plate subarray are the same; During treatment, each tumor lesion is projected onto a different fixed electrode plate sub-array, and the fixed electrode plate sub-array corresponding to the largest projected area is selected as the fixed electrode plate sub-array to be activated; Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor lesion; The fixed electrode plate sub-array is on one side of the tumor lesion, and the movable electrode plate sub-array is moved to the other side of the corresponding tumor lesion, so that the center of the movable electrode plate sub-array moves to the straight line and is perpendicular to the straight line. The movable electrode plate sub-array and the fixed electrode plate sub-array to be turned on are the electrode plate arrays that need to be turned on; The electrode plates on the movable electrode plate sub-array are matched in pairs with the electrode plates on the fixed electrode plate array to be turned on, and each electrode pair forms two poles of the alternating electric field.

9. The electric field application control system of the multi-lesion dynamic non-invasive non-contact treatment device according to claim 7, characterized in that: The electrode plate array includes a plurality of fixed electrode plate sub-arrays and a movable electrode plate sub-array; Each electrode plate sub-array includes a plurality of independently operable electrode plates. During treatment, a fixed electrode plate sub-array is determined to form an electrode plate array pair with the movable electrode plate sub-array. The number of electrode plates on the fixed electrode plate subarray and the number of electrode plates on the movable electrode plate subarray are the same; During treatment, the tumor is projected onto different fixed electrode plate sub-arrays, and the fixed electrode plate sub-array corresponding to the largest projected area is selected as the fixed electrode plate sub-array to be activated; Draw a straight line through the center of the fixed electrode plate array to be turned on and the center of the tumor; The fixed electrode plate subarray is on one side of the tumor, and the electrode plates on each movable electrode plate subarray can independently change their orientation so that the center of the movable electrode plate subarray moves to the straight line and is perpendicular to the straight line; The electrode plates on the movable electrode plate sub-array are matched in pairs with the electrode plates on the fixed electrode plate array to be turned on, and each electrode pair forms two poles of the alternating electric field.

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