Composite iodophor disinfectant, and preparation equipment and method thereof

Abstract

The invention relates to the technical field of disinfectant preparation, in particular to a composite iodophor disinfectant and preparation equipment and method.The mixing assembly comprises a stirring motor, a stirring rod, a bottom stirring blade, a sliding blade set, a rotating ring, a connecting ring and a driving air cylinder; the stirring motor is fixed to the cover plate, the stirring rod is connected with the output end of the stirring motor, the bottom stirring blade is fixed to the bottom of the stirring rod, the connecting ring is slidably arranged on one side of the stirring rod, and the rotating ring is rotationally connected with the connecting ring; the sliding blade set comprises a first sliding blade, a limiting sleeve and a second sliding blade, the first sliding blade is slidably arranged on the stirring rod, the limiting sleeve is fixed to one side of the first sliding blade, the second sliding blade is slidably arranged on the limiting sleeve, the rotating ring is rotationally connected with the second sliding blade, and the output end of the driving air cylinder is connected with the rotating ring. The stirring height of the blades can be adjusted, so that solid materials and liquid materials can be sufficiently stirred respectively.

Description

Technical Field

[0001] The present invention relates to the technical field of disinfectant preparation, in particular to a composite iodine tincture disinfectant, a preparation device and a preparation method. Background Art

[0002] Iodine-containing disinfectant is a widely used disinfectant. Its main component is a complex of iodine with a surfactant and a solvent. It has a broad-spectrum bactericidal effect, effectively killing bacteria, fungi, viruses, and some spore-forming microorganisms. It is suitable for disinfecting skin, mucous membranes, and wounds. Compared with traditional iodine tincture, iodine-containing disinfectant is less irritating, less likely to cause allergic reactions, and does not stain the skin. Therefore, it is widely used in medical treatment, home care, and personal hygiene. When using, dilute according to the instructions or apply directly to ensure safe and effective disinfection.

[0003] In the preparation process of disinfectant, stirring is a very critical link, which directly affects the uniformity, stability and disinfection effect of the final product. Generally, the preparation process is divided into two main stages: first, the solid materials are mixed and stirred, and then the overall solution is further stirred after the liquid components are added to ensure that the components are fully integrated. In actual operation, especially when dealing with smaller solid materials, the problem of insufficient stirring is often encountered. Due to the small amount of solid material used, it is easy to be unevenly distributed, agglomerated, or adhere to the container wall and the stirring paddle during the stirring process, resulting in it not being able to fully contact and react with the subsequently added liquid materials. Summary of the Invention

[0004] The present invention aims to provide a composite iodine disinfectant, a preparation device and a method thereof, which are designed to adjust the stirring height of blades so as to facilitate sufficient stirring of solid materials and liquid materials respectively.

[0005] To achieve the above-mentioned purpose, in a first aspect, the present invention provides a composite iodine tincture disinfectant preparation device, comprising a support assembly, wherein the support assembly comprises a stirring shell, a cover plate, a feed pipe and a protective gas input device, wherein the cover plate is fixedly connected to the stirring shell and is located at the top of the stirring shell, the feed pipe is arranged on the cover plate, and the protective gas input device is arranged on one side of the cover plate; the support assembly further comprises a mixing assembly, wherein the mixing assembly comprises a stirring motor, a stirring rod, a bottom stirring blade, a sliding blade group, a rotating ring, a connecting ring and a driving cylinder; the stirring motor is fixed on the cover plate, the stirring rod is connected to the output end of the stirring motor, the bottom stirring blade is fixed to the bottom of the stirring rod, the connecting ring is slidably arranged on one side of the stirring rod, and the rotating ring is rotatably connected to the connecting ring;

[0006] The sliding blade group includes a first sliding blade, a limiting sleeve, and a second sliding blade. The first sliding blade is slidably arranged on the stirring rod, the limiting sleeve is fixed on one side of the first sliding blade, and the second sliding blade is slidably arranged on the limiting sleeve. The rotating ring is rotatably connected to the second sliding blade, and the output end of the driving cylinder is connected to the rotating ring.

[0007] Wherein, the mixing assembly further includes a spacer ring, which is arranged between the first sliding blade and the bottom stirring blade.

[0008] Wherein, the sliding blade assembly further includes an elastic member, and the elastic member is arranged between the limiting sleeve and the second sliding blade.

[0009] The sliding blade assembly further includes a push ring and a sealing ring. The push ring is arranged at the bottom of the first sliding blade, and the sealing ring is arranged between the push ring and the stirring rod. The push ring is used to clean the raw materials on the stirring rod.

[0010] In a second aspect, the present invention further provides a method for preparing a composite iodine disinfectant, comprising:

[0011] Under the protection of nitrogen generated by the protective gas input device, polyvinyl pyrrolidone and iodine are placed in the stirring shell, and the sliding blade group is driven to move down to the bottom to stir and form an iodine complex;

[0012] Add the ethanol-water solvent containing surfactant into the stirring shell and stir at a temperature of 20-25°C;

[0013] Add citric acid-sodium citrate buffer, panthenol, hyaluronic acid and tea tree oil extract to adjust the pH to 3.5-4.5;

[0014] Add vitamin E and sodium sulfite, mix well under light-proof conditions, and obtain a compound iodine-containing disinfectant.

[0015] The specific steps of placing polyvinyl pyrrolidone and iodine into a stirring shell under the protection of nitrogen generated by a protective gas input device, and driving the sliding blade group to move downward to the bottom for stirring to form an iodine complex include:

[0016] The polyvinyl pyrrolidone powder is dried in advance to remove moisture;

[0017] In a nitrogen-filled stirring shell, polyvinyl pyrrolidone and iodine were added alternately in a ratio of 9:1 to 10:1 in three additions, with an interval of 5 minutes, a stirring speed of 200 to 300 rpm, and a temperature controlled at 20±2°C for 30 minutes until an iodine complex was formed.

[0018] The specific steps of adding the ethanol-water solvent containing the surfactant into the stirring shell and stirring at a stirring temperature of 20 to 25° C. include:

[0019] Ethanol and purified water were mixed at a temperature of 10°C to 15°C, and a surfactant was added for ultrasonic degassing;

[0020] First, premix 50% solvent and iodine complex into a slurry at a speed of 100 rpm to 200 rpm and a stirring temperature of 20 to 25°C;

[0021] The remaining solvent was added in two portions, each time increasing the stirring speed to 500 rpm and maintaining for 15 min.

[0022] The specific steps of adding citric acid-sodium citrate buffer, panthenol, hyaluronic acid and tea tree oil extract to adjust the pH to 3.5-4.5 include:

[0023] Dissolve citric acid-sodium citrate in 5% formula water, preheat to 30°C, and slowly add to the stirring shell. Monitor the pH value to 4.0±0.1 with an online pH meter.

[0024] Add panthenol and hyaluronic acid to the stirring shell and stir for 10 minutes at 200 rpm;

[0025] Pre-emulsify the tea tree oil extract and add it.

[0026] The specific steps of adding vitamin E and sodium sulfite and mixing them in the dark to obtain the composite iodine disinfectant include:

[0027] Dissolve vitamin E in ethanol solution and sodium sulfite in 5% water, and filter them separately;

[0028] Add vitamin E solution and stir in a stirring shell for 5 minutes, then add sodium sulfite solution dropwise to obtain a composite iodine disinfectant preform;

[0029] The composite iodine tincture disinfectant preform was filtered through a 0.45 μm microporous filter, filled with nitrogen, and sealed in an aluminum foil bag to avoid light.

[0030] In a third aspect, the present invention also provides a composite iodine disinfectant, wherein the components of the composite iodine disinfectant include, by weight percentage, 0.5% to 1.2% iodine; 5% to 10% polyvinyl pyrrolidone; 50% to 70% ethanol aqueous solution; 0.5% to 2% surfactant; 0.1% to 0.5% citric acid-sodium citrate buffer; 0.01% to 0.1% complex of vitamin E and sodium sulfite; 0.02% to 0.03% panthenol, 0.01% to 0.04% hyaluronic acid and 0.05% to 0.1% tea tree oil extract.

[0031] A kind of composite iodine tincture disinfectant, preparation equipment and method of the present invention, the stirring shell is the main body container of the whole equipment, is used to accommodate the liquid raw material to be mixed, and has certain corrosion resistance and sealing performance, to ensure the safety and stability of the mixing process. The cover plate is fixedly connected to the top of the stirring shell, plays the role of closing the stirring chamber, prevents external impurities from entering or materials from splashing. The feed pipe is arranged on the cover plate, as an input channel for multiple raw materials (such as iodine, surfactant, stabilizer, etc.), it is convenient to add different ingredients in proportion. The protective gas input device is arranged on one side of the cover plate, for passing inert gas (such as nitrogen) into the stirring shell, to reduce the occurrence of oxidation reaction, and ensure the quality and stability of the finished product.

[0032] The stirring motor is fixedly mounted on the cover plate, and its output end is connected to the stirring rod, which is driven by the motor to rotate. The bottom stirring blade is fixed to the bottom of the stirring rod and is used to vigorously stir the material at the bottom of the stirring shell to prevent sedimentation.

[0033] To further enhance mixing efficiency and uniformity, the device also features a sliding blade assembly, comprising a first sliding blade, a limiting sleeve, and a second sliding blade. The first sliding blade can slide up and down along the stirring rod to accommodate stirring at varying liquid levels. The limiting sleeve is secured to one side of the first sliding blade, limiting the second sliding blade's range of motion. The second sliding blade slides within the limiting sleeve and is rotatably connected to it via a rotating ring, enabling the blade to automatically adjust its stirring height based on fluid resistance during stirring.

[0034] The connecting ring is slidingly arranged on one side of the stirring rod, and the rotating ring forms a rotating connection with the connecting ring, so that the entire sliding blade group can rotate together with the stirring rod and can also be dynamically adjusted according to the action of the driving cylinder. Specifically, the driving cylinder can drive the connecting ring to move up and down, thereby driving the rotating ring to move. The rotating ring can drive the limit sleeve to move up or down to change the stirring height of the sliding blade, so that when stirring solid substances, the sliding blade can be moved down to the bottom to fully stir the polyvinyl pyrrolidone and iodine at the bottom, and then an ethanol-water solvent containing a surfactant is added to the stirring shell, and then the first sliding blade and the second sliding blade are lifted to stir the liquid, thereby realizing a multi-dimensional and multi-level mixing method, effectively improving the mixing efficiency and the quality of the finished product. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0036] Figure 1 The present invention is a structural diagram of a composite iodine tincture disinfectant preparation device.

[0037] Figure 2 This is the right side structural diagram of a composite iodine tincture disinfectant preparation device of the present invention.

[0038] Figure 3 The present invention is a cross-sectional structural diagram of a composite iodine tincture disinfectant preparation device.

[0039] Figure 4 The invention discloses a longitudinal cross-sectional structural diagram of a composite iodine tincture disinfectant preparation device.

[0040] Figure 5 yes Figure 4 A partial enlargement of detail A.

[0041] Figure 6 The present invention is a flow chart of a method for preparing a composite iodine tincture disinfectant.

[0042] Figure 7 The invention is a flow chart of placing polyvinyl pyrrolidone and iodine into a stirring shell under the protection of nitrogen generated by a protective gas input device, and driving a sliding blade group to move downward to the bottom for stirring to form an iodine complex.

[0043] Figure 8 The invention discloses a flow chart of adding an ethanol-water solvent containing a surfactant into a stirring shell and stirring the solvent at a temperature of 20 to 25°C.

[0044] Figure 9 This is a flow chart of the present invention for adding citric acid-sodium citrate buffer, panthenol, hyaluronic acid and tea tree oil extract to adjust the pH to 3.5-4.5.

[0045] Figure 10 The invention discloses a flow chart of adding vitamin E and sodium sulfite, mixing them evenly under light-proof conditions, and obtaining a composite iodine disinfectant.

[0046] Stirring shell 101, cover plate 102, feed pipe 103, protective gas input device 104, stirring motor 105, stirring rod 106, bottom stirring blade 107, sliding blade group 108, rotating ring 109, connecting ring 110, driving cylinder 111, first sliding blade 112, limiting sleeve 113, second sliding blade 114, spacer ring 115, elastic member 116, push ring 117, sealing ring 118. DETAILED DESCRIPTION

[0047] The following describes embodiments of the present invention in detail, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and are not to be construed as limiting the present invention.

[0048] In the description of the present invention, it should be understood that the terms "length," "width," "up," "down," "front," "back," "left," "right," "vertical," "horizontal," "top," "bottom," "inside," "outside," and the like, indicating positions or location relationships, are based on the positions or location relationships shown in the accompanying drawings and are intended only to facilitate the description of the present invention and simplify the description. They do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limiting the present invention. Furthermore, in the description of the present invention, "plurality" means two or more, unless otherwise expressly and specifically defined.

[0049] First embodiment

[0050] See also Figures 1 to 5The present invention provides a composite iodine tincture disinfectant preparation device, including a support assembly, the support assembly including a stirring shell 101, a cover plate 102, a feed pipe 103 and a protective gas input device 104, the cover plate 102 is fixedly connected to the stirring shell 101 and is located on the top of the stirring shell 101, the feed pipe 103 is arranged on the cover plate 102, the protective gas input device 104 is arranged on one side of the cover plate 102, and also includes a mixing assembly, the mixing assembly including a stirring motor 105, a stirring rod 106, a bottom stirring blade 107, a sliding blade group 108, a rotating ring 109, a connecting ring 110 and a driving cylinder 111; the stirring motor 105 is fixed on the cover plate 102, the stirring rod 106 is fixed to the bottom stirring blade 107, a sliding blade group 108, a rotating ring 109, a connecting ring 110 and a driving cylinder 111; the stirring motor 105 is fixed on the cover plate 102, and the stirring rod 106 is fixed to the bottom stirring blade 107. The output end of the stirring motor 105 is connected, the bottom stirring blade 107 is fixed to the bottom of the stirring rod 106, the connecting ring 110 is slidably set on one side of the stirring rod 106, and the rotating ring 109 is rotatably connected to the connecting ring 110; the sliding blade group 108 includes a first sliding blade 112, a limiting sleeve 113, and a second sliding blade 114, the first sliding blade 112 is slidably set on the stirring rod 106, the limiting sleeve 113 is fixed on one side of the first sliding blade 112, the second sliding blade 114 is slidably set on the limiting sleeve 113, the rotating ring 109 is rotatably connected to the second sliding blade 114, and the output end of the driving cylinder 111 is connected to the rotating ring 109.

[0051] In this embodiment, the stirring shell 101 is the main container of the entire equipment, which is used to accommodate the liquid raw materials to be mixed, and has certain corrosion resistance and sealing properties to ensure the safety and stability of the mixing process. The cover plate 102 is fixedly connected to the top of the stirring shell 101, and serves to close the stirring chamber to prevent external impurities from entering or materials from splashing. The feed pipe 103 is arranged on the cover plate 102 as an input channel for a variety of raw materials (such as iodine, surfactants, stabilizers, etc.), which is convenient for adding different ingredients in proportion. The protective gas input device 104 is arranged on one side of the cover plate 102, and is used to introduce an inert gas (such as nitrogen) into the interior of the stirring shell 101 to reduce the occurrence of oxidation reactions and ensure the quality and stability of the finished product.

[0052] The stirring motor 105 is fixedly mounted on the cover plate 102, and its output end is connected to the stirring rod 106, which is driven by the motor to rotate the stirring rod 106. The bottom stirring blade 107 is fixed to the bottom of the stirring rod 106 and is used to vigorously stir the material at the bottom of the stirring shell 101 to prevent sedimentation.

[0053] To further enhance mixing efficiency and uniformity, the device also features a sliding blade assembly 108, comprising a first sliding blade 112, a limiting sleeve 113, and a second sliding blade 114. The first sliding blade 112 can slide up and down along the stirring rod 106 to accommodate stirring at varying liquid levels. The limiting sleeve 113, secured to one side of the first sliding blade 112, limits the range of movement of the second sliding blade 114. The second sliding blade 114 can slide within the limiting sleeve 113 and is rotatably connected to it via a rotating ring 109, enabling the blades to automatically adjust the stirring height based on fluid resistance during stirring.

[0054] The connecting ring 110 is slidably arranged on one side of the stirring rod 106, and the rotating ring 109 is rotatably connected to the connecting ring 110, so that the entire sliding blade group 108 can rotate together with the stirring rod 106 and can also be dynamically adjusted according to the action of the driving cylinder 111. Specifically, the driving cylinder 111 can drive the connecting ring 110 to move up and down, thereby driving the rotating ring 109 to move. The rotating ring 109 can drive the limiting sleeve 113 to move up or down to change the stirring height of the sliding blade, so that when stirring solid substances, the sliding blade can be moved down to the bottom to fully stir the polyvinyl pyrrolidone and iodine at the bottom, and then an ethanol-water solvent containing a surfactant is added to the stirring shell 101, and then the first sliding blade 112 and the second sliding blade 114 are raised to stir the liquid, thereby realizing a multi-dimensional and multi-level mixing method, effectively improving the mixing efficiency and the quality of the finished product.

[0055] The mixing assembly further includes a spacer ring 115 , which is disposed between the first sliding blade 112 and the bottom stirring blade 107 .

[0056] The spacer ring 115 is positioned between the first sliding blade 112 and the bottom stirring blade 107. The spacer ring 115 maintains a certain distance between the first sliding blade 112 and the bottom stirring blade 107, preventing direct contact or interference between the two during the stirring process, thereby ensuring that the stirring components can operate independently and in a coordinated manner. Furthermore, the spacer ring 115 serves as a flow guide, directing the flow of liquid during stirring, enhancing the upward and downward circulation of the material, and improving overall mixing efficiency.

[0057] The sliding blade assembly 108 further includes an elastic member 116 , which is disposed between the limiting sleeve 113 and the second sliding blade 114 .

[0058] The sliding blade assembly 108 also includes an elastic member 116, which is positioned between the stop sleeve 113 and the second sliding blade 114. This elastic member 116 is typically a spring or elastic rubber pad, and its primary function is to provide a certain amount of cushioning force and reset capability for the second sliding blade 114 during the stirring process. When there is significant resistance or uneven distribution within the stirred liquid, the second sliding blade 114 can be appropriately extended and retracted relative to the stop sleeve 113 and automatically reset by the elastic force of the elastic member 116, effectively preventing blade damage or structural jamming caused by excessive force.

[0059] The sliding blade assembly 108 further includes a push ring 117 and a sealing ring 118 . The push ring 117 is disposed at the bottom of the first sliding blade 112 , and the sealing ring 118 is disposed between the push ring 117 and the stirring rod 106 . The push ring 117 is used to clean the raw materials on the stirring rod 106 .

[0060] The push ring 117 is fixedly connected to the bottom of the first sliding blade 112 and moves synchronously with the first sliding blade 112 sliding up and down along the stirring rod 106. Its main function is to physically scrape off the raw materials or mixture adhering to the surface of the stirring rod 106 during the stirring process, preventing the materials from being retained, accumulated, or even solidified on the stirring rod 106 for a long time, thereby avoiding affecting the subsequent mixing effect and the stability of the equipment operation.

[0061] The sealing ring 118 is arranged between the push ring 117 and the stirring rod 106, and plays a good sealing and protective role. Since the raw materials of the compound iodine tincture disinfectant may have certain corrosiveness or adhesion, if it enters the interior of the sliding blade group 108, it may cause erosion or jamming to the sliding structure and rotating parts of the equipment. Therefore, the presence of the sealing ring 118 can effectively prevent liquid from penetrating into key moving parts, keep the internal structure clean and dry, and ensure the smooth operation and long-term reliability of the sliding blade group 108.

[0062] Second embodiment

[0063] See also Figures 6 to 10 The present invention also provides a method for preparing a composite iodine disinfectant, comprising:

[0064] S101 , under the protection of nitrogen gas generated by the protective gas input device 104 , polyvinyl pyrrolidone and iodine are placed in the stirring shell 101 , and the sliding blade assembly 108 is driven to move downward to the bottom for stirring to form an iodine complex;

[0065] Specific steps include;

[0066] S201 pre-dry the polyvinyl pyrrolidone powder to remove moisture.

[0067] Since PVP has a certain degree of hygroscopicity, in order to avoid the presence of moisture in the subsequent reaction process affecting the efficiency and stability of the iodine complex, it needs to be placed in a drying device and dried under constant temperature conditions. The temperature is usually controlled between 50 and 60°C and the duration is 1 to 2 hours to fully remove the moisture and ensure that it is in a dry state for use.

[0068] S202: In a nitrogen-filled stirring shell 101, polyvinyl pyrrolidone and iodine are added alternately in a ratio of 9:1 to 10:1 three times, with an interval of 5 minutes, a stirring speed of 200 to 300 rpm, and a temperature controlled at 20±2°C for 30 minutes until an iodine complex is formed.

[0069] After the drying process is completed, the protective gas input device 104 is turned on, and high-purity nitrogen is introduced into the stirring shell 101 to replace the stirring cavity with inert gas and discharge oxygen and moisture in the air, thereby constructing a low-oxygen, dry reaction environment to prevent unnecessary oxidation or volatilization of iodine during the reaction, thereby improving the safety of the reaction and the stability of the product. Under this nitrogen protection environment, the ingredients are prepared according to a mass ratio of polyvinyl pyrrolidone to iodine of 9:1 to 10:1. Preferably, a ratio of 10:1 can be used to obtain the best complexing effect and antibacterial properties. The weighed raw materials are added step by step in the following manner:

[0070] Stage 1: First add about 1 / 3 of the total amount of polyvinyl pyrrolidone powder;

[0071] Second stage: After a 5-minute interval, add the corresponding proportion of iodine particles or flake crystals;

[0072] The third stage: After another 5 minutes, add the remaining polyvinyl pyrrolidone powder to ensure that the material is evenly distributed in the stirring chamber.

[0073] During the entire feeding process, the stirring motor 105 is kept running at a low speed (about 100 rpm) to initially disperse the materials and prevent dust from flying or local concentration from being too high.

[0074] After all raw materials have been added, the mixing assembly is activated, the stirring speed is adjusted to 200-300 rpm, and the drive cylinder 111 system of the sliding blade assembly 108 is activated, causing the sliding blade assembly 108 to rotate with the stirring rod 106 and move up and down along the axis of the stirring rod 106, thereby enhancing the shear force and mixing efficiency in the stirring area. The entire reaction system is maintained at a constant temperature of 20±2°C. This temperature range helps promote the complexation reaction between PVP and iodine while preventing iodine volatilization or changes in the PVP structure caused by excessively high temperatures.

[0075] S102: adding an ethanol-water solvent containing a surfactant into the stirring shell 101 and stirring at a temperature of 20-25°C.

[0076] The specific steps include:

[0077] S301: Mix ethanol and purified water at a temperature of 10°C to 15°C, add a surfactant, and perform ultrasonic treatment for degassing.

[0078] Prepare an ethanol-water mixed solvent containing a surfactant. Specifically, analytical grade ethanol and purified water are mixed in a specific ratio (e.g., 7:3 or 6:4) in a constant ambient temperature of 10°C to 15°C. This low temperature helps reduce ethanol volatilization losses and improves the dissolution efficiency and stability of the subsequent surfactant. Subsequently, an appropriate amount of surfactant is added to the mixed solvent. Commonly used surfactants include polyoxyethylene hydrogenated castor oil (RH40), Tween series (e.g., Tween-80), or sodium dodecyl sulfate (SDS) to enhance the wettability, permeability, and stability of the final product.

[0079] After adding the surfactant, the entire mixture is degassed by ultrasonic treatment, typically using an ultrasonic device with a frequency of 20 to 40 kHz for 10 to 30 minutes. This process effectively removes dissolved air and tiny bubbles from the solvent system, preventing uneven mixing or localized concentration abnormalities caused by residual bubbles during subsequent stirring. It also helps to fully disperse and activate the surfactant molecules.

[0080] S302: First, 50% of the solvent and the iodine complex are premixed into a slurry at a speed of 100 rpm to 200 rpm, and the stirring temperature is 20 to 25°C.

[0081] 50% of the total amount of the prepared ethanol-water mixed solvent is slowly added to the iodine complex formed in the stirring shell 101. At this time, the stirring system is started, the stirring speed is set to 100 rpm to 200 rpm, and the material is gradually formed into a slurry mixture with a certain viscosity under continuous stirring. During this process, the temperature in the stirring shell 101 is controlled to be maintained between 20°C and 25°C. The temperature can be accurately controlled by an external cooling jacket or a heating circulation system to prevent excessive temperature from causing volatilization of iodine or destruction of the surfactant structure.

[0082] The remaining solvent in S303 was added in two portions, each time increasing the stirring speed to 500 rpm and maintaining for 15 minutes.

[0083] After completing the initial premixing, start adding the remaining 50% solvent in batches. The amount added each time is about half of the remaining solvent, and a total of two additions are made. After each addition of solvent, immediately increase the stirring speed to 500 rpm and maintain this high-speed stirring state for 15 minutes. Through the high-speed shearing effect, the agglomeration phenomenon in the material can be further broken, the uniform dispersion of the iodine complex in the solvent system can be promoted, and the transparency and stability of the solution can be improved. At the same time, the sliding blade group 108 works together at this stage to enhance the three-dimensional flow of the material through up and down sliding and the driving mode of the rotating ring 109, thereby improving the overall mixing uniformity.

[0084] S103 adds citric acid-sodium citrate buffer, panthenol, hyaluronic acid and tea tree oil extract to adjust the pH to 3.5-4.5.

[0085] The specific steps include:

[0086] S401: Dissolve citric acid-sodium citrate in 5% formula water, preheat to 30°C, and slowly add to the stirring shell 101. Monitor the pH value to 4.0±0.1 with an online pH meter.

[0087] To maintain the pH stability of the iodine-containing disinfectant system and prevent inactivation or structural damage to the active ingredients due to changes in the external environment or during storage, first accurately weigh the citric acid-sodium citrate buffer solution at a specific molar ratio (usually 1:1 to 2:1) and dissolve it in 5% formulation water (i.e., 5% of the total formulation water volume). The purified water used must be pre-degassed to reduce the generation of bubbles during subsequent stirring.

[0088] Subsequently, the buffer solution is preheated to 30°C in a constant temperature water bath to improve the dissolution efficiency and avoid causing severe disturbances to the system temperature. Then, while stirring is in continuous operation, it is slowly added dropwise or pumped into the mixed system in the stirring shell 101 to avoid pH fluctuations caused by excessive local concentration. During this process, the online pH meter equipped with the equipment monitors the changes in the pH value of the system in real time, and adjusts the addition rate through feedback from the control system until the pH of the system stabilizes within the range of 4.0±0.1. This pH range can not only ensure the stability of the iodine complex, but also take into account the adaptability to the physiological environment of the skin and reduce irritation.

[0089] S402: Add panthenol and hyaluronic acid into the stirring shell 101 and stir for 10 minutes at a rotation speed of 200 rpm.

[0090] After pH adjustment, the functional skincare ingredients are added. Panthenol, a precursor to vitamin B5, possesses excellent moisturizing, repairing, and anti-inflammatory properties. Hyaluronic acid (HA), known for its excellent water-retention properties, enhances the product's ability to protect the skin barrier.

[0091] After weighing panthenol and hyaluronic acid according to the designed ratio, add them sequentially to the mixing shell 101. To avoid clumping and uneven dissolution, it is recommended to pre-mix them using a dry method or wet-wet them before adding them to the system. Start the stirring system at 200 rpm and stir continuously for 10 minutes to ensure that both ingredients are fully dissolved and evenly distributed in the mixture. During this process, the sliding blade assembly 108 continues to function, promoting rapid diffusion and fusion of the materials through up and down motion and rotational shearing, ensuring the uniformity of the final product.

[0092] S403 pre-emulsifies the tea tree oil extract and then adds it.

[0093] Tea tree oil extract is a natural, plant-derived, broad-spectrum antimicrobial agent with excellent synergistic effects, further enhancing the bactericidal efficacy of iodine-containing disinfectants. It is particularly effective against Gram-positive bacteria, fungi, and some viruses. However, due to its strong hydrophobicity and incompatibility with aqueous systems, direct addition can easily lead to stratification or aggregation, compromising product quality.

[0094] Therefore, pre-emulsification is required before addition. Specifically, the tea tree oil extract is mixed with an appropriate amount of surfactant (such as Tween 80 or lecithin) and a small amount of water. The mixture is then homogenized and emulsified in a high-speed shear emulsifier to form a stable microemulsion with uniform particle size. This pre-emulsified tea tree oil system exhibits excellent hydrophilicity and dispersibility.

[0095] Subsequently, under the continuous stirring state of the stirring shell 101, the pre-emulsified tea tree oil extract is slowly added to the main system, and the stirring speed is still maintained at about 200 rpm. Stirring is continued for 10 to 15 minutes to ensure that it is fully mixed with the remaining components to form a homogeneous and stable composite iodine disinfectant system.

[0096] S104 adds vitamin E and sodium sulfite, mixes under dark conditions, and obtains a composite iodine disinfectant.

[0097] The specific steps include:

[0098] S501: Dissolve vitamin E in ethanol solution and sodium sulfite in 5% water, and filter them separately;

[0099] To ensure that the two additives can be quickly and evenly dispersed in the main system and reduce the risk of impurities being introduced, they need to be dissolved, filtered and other pretreatment operations before adding.

[0100] Add a certain amount of vitamin E (α-tocopherol) to an appropriate amount of anhydrous ethanol solution and stir until it is completely dissolved to form a homogeneous solution. Since vitamin E is a fat-soluble antioxidant, using ethanol as a solvent can effectively improve its dispersibility and stability in the subsequent aqueous phase system.

[0101] Heat 5% of the total formula in purified water to 30-40°C to enhance dissolution. Slowly add the weighed sodium sulfite (Na2SO3) and stir until completely dissolved. Sodium sulfite is a commonly used water-soluble antioxidant that effectively scavenges trace oxygen from the system, preventing excessive oxidation of iodine.

[0102] S502 adds vitamin E solution into stirring shell 101 and stirs for 5 minutes, then adds sodium sulfite solution dropwise to obtain a composite iodine disinfectant preform;

[0103] After completing the addition and mixing of other functional ingredients in the main system (such as buffer, panthenol, hyaluronic acid, tea tree oil extract, etc.), the key stage of this step begins:

[0104] While the stirring shell 101 is in continuous operation, the pre-filtered vitamin E ethanol solution is slowly added to the main system, the stirring speed is set to 200-300 rpm, and stirring is continued for 5 minutes to achieve initial uniform distribution of vitamin E in the system and exert its fat-soluble antioxidant effect.

[0105] While maintaining stirring, slowly add the sodium sulfite aqueous solution dropwise into the stirring shell 101 using a drip pump or a constant flow pump. The dripping rate is controlled at 10-20 mL per minute to avoid drastic pH fluctuations or local reactions caused by excessively high local concentrations. After the dropwise addition is completed, continue stirring for 10-15 minutes to ensure that the system is fully mixed and uniform, forming a composite iodine disinfectant preform.

[0106] S503: The composite iodine tincture disinfectant preform is filtered through a 0.45 μm micropore filter, filled with nitrogen, and sealed in an aluminum foil bag to avoid light.

[0107] To ensure the physical uniformity, microbiological safety and long-term stability of the final product, the preformed product needs to be finely filtered and aseptically filled after all components are mixed:

[0108] The composite iodine tincture disinfectant preform is finely filtered through a 0.45 μm microporous filter membrane to remove any remaining particulate impurities, undissolved matter or potential microbial contamination in the system, ensuring that the product is clear and transparent and the quality is controllable.

[0109] The filtered product is transferred to the filling system, where it is quantitatively filled under nitrogen protection. Brown glass bottles or aluminum-plastic composite bags are typically used as containers to further isolate the product from oxygen and light. The filling process is designed to minimize splashing and foaming to ensure filling accuracy and consistent appearance.

[0110] After filling, immediately seal the package in an aluminum foil bag or multi-layer composite packaging material to avoid light, and mark the outer packaging with information such as the expiration date, batch number, and storage conditions. The product should be stored in a cool, dry place, away from direct sunlight, to maximize its chemical stability and antimicrobial activity.

[0111] According to the above steps, four different ratios were selected to prepare four types of compound iodine disinfectants:

[0112] Example 1

[0113]

[0114] Example 2

[0115]

[0116] Example 3

[0117]

[0118] Example 4

[0119]

[0120]

[0121] The finished product prepared in the above manner was compared with a commercially available common iodine disinfectant, and the experimental data table obtained is as follows:

[0122]

[0123] The above disclosure is only a preferred embodiment of the present invention, and certainly cannot be used to limit the scope of the rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made in accordance with the claims of the present invention are still within the scope of the invention.

Claims

1. A preparation device for a composite iodine disinfectant, comprising a support assembly, wherein the support assembly comprises a stirring shell, a cover plate, a feed pipe and a protective gas input device, wherein the cover plate is fixedly connected to the stirring shell and is located at the top of the stirring shell, the feed pipe is arranged on the cover plate, and the protective gas input device is arranged on one side of the cover plate, characterized in that: The invention also includes a mixing assembly, which includes a stirring motor, a stirring rod, a bottom stirring blade, a sliding blade group, a rotating ring, a connecting ring and a driving cylinder; the stirring motor is fixed to the cover plate, the stirring rod is connected to the output end of the stirring motor, the bottom stirring blade is fixed to the bottom of the stirring rod, the connecting ring is slidably arranged on one side of the stirring rod, and the rotating ring is rotatably connected to the connecting ring; The sliding blade group includes a first sliding blade, a limiting sleeve, and a second sliding blade. The first sliding blade is slidably arranged on the stirring rod, the limiting sleeve is fixed on one side of the first sliding blade, and the second sliding blade is slidably arranged on the limiting sleeve. The rotating ring is rotatably connected to the second sliding blade, and the output end of the driving cylinder is connected to the rotating ring.

2. The preparation method of a compound iodine disinfectant according to claim 1, wherein The mixing assembly further includes a spacer ring disposed between the first sliding blade and the bottom stirring blade.

3. The preparation device of a compound iodine disinfectant as claimed in claim 2, wherein The sliding blade assembly further includes an elastic member, which is arranged between the limiting sleeve and the second sliding blade.

4. The preparation device of a compound iodine disinfectant as claimed in claim 3, wherein The sliding blade assembly further includes a push ring and a sealing ring. The push ring is arranged at the bottom of the first sliding blade, and the sealing ring is arranged between the push ring and the stirring rod. The push ring is used to clean the raw materials on the stirring rod.

5. A method for preparing a compound iodine-containing disinfectant, using the preparation equipment of a compound iodine-containing disinfectant according to claims 1 to 4, characterized in that: include: Under the protection of nitrogen generated by the protective gas input device, polyvinyl pyrrolidone and iodine are placed in the stirring shell, and the sliding blade group is driven to move down to the bottom to stir and form an iodine complex; Add the ethanol-water solvent containing surfactant into the stirring shell and stir at a temperature of 20-25°C; Add citric acid-sodium citrate buffer, panthenol, hyaluronic acid and tea tree oil extract to adjust the pH to 3.5-4.5; Add vitamin E and sodium sulfite, mix well under light-proof conditions, and obtain a compound iodine-containing disinfectant.

6. The preparation method of a composite iodine disinfectant according to claim 5, wherein The specific steps of placing polyvinyl pyrrolidone and iodine into the stirring shell under the protection of nitrogen generated by the protective gas input device, and driving the sliding blade group to move down to the bottom to stir and form an iodine complex include: The polyvinyl pyrrolidone powder is pre-dried to remove moisture; In a nitrogen-filled stirring shell, polyvinyl pyrrolidone and iodine were added alternately in a ratio of 9:1 to 10:1 in three additions, with an interval of 5 minutes, a stirring speed of 200 to 300 rpm, and a temperature controlled at 20±2°C for 30 minutes until an iodine complex was formed.

7. The preparation method of a composite iodine disinfectant according to claim 6, wherein The specific steps of adding the ethanol-water solvent containing the surfactant into the stirring shell and stirring at a stirring temperature of 20 to 25° C. include: Ethanol and purified water were mixed at a temperature of 10°C to 15°C, and a surfactant was added for ultrasonic degassing; First, premix 50% of the solvent and the iodine complex into a slurry at a speed of 100 rpm to 200 rpm and a stirring temperature of 20 to 25°C; The remaining solvent was added in two portions, each time increasing the stirring speed to 500 rpm and maintaining for 15 min.

8. The preparation method of a composite iodine disinfectant according to claim 7, wherein The specific steps of adding citric acid-sodium citrate buffer, panthenol, hyaluronic acid and tea tree oil extract to adjust the pH to 3.5-4.5 include: Dissolve citric acid-sodium citrate in 5% formula water, preheat to 30°C, and slowly add to the stirring shell. Monitor the pH value to 4.0±0.1 with an online pH meter. Add panthenol and hyaluronic acid to the stirring shell and stir for 10 minutes at 200 rpm; Pre-emulsify the tea tree oil extract and add it.

9. The preparation method of a composite iodine disinfectant according to claim 8, wherein The specific steps of adding vitamin E and sodium sulfite and mixing them in the dark to obtain the composite iodine disinfectant include: Dissolve vitamin E in ethanol solution and sodium sulfite in 5% water, and filter them separately; Add vitamin E solution and stir in a stirring shell for 5 minutes, then add sodium sulfite solution dropwise to obtain a composite iodine disinfectant preform; The composite iodine tincture disinfectant preform was filtered through a 0.45 μm microporous filter, filled with nitrogen, and sealed in an aluminum foil bag to avoid light.

10. A composite iodine tincture disinfectant, prepared by the method for preparing a composite iodine tincture disinfectant according to claim 5, characterized in that: The components of the compound iodine disinfectant include, by weight percentage, 0.5% to 1.2% of iodine; 5% to 10% of polyvinyl pyrrolidone; 50% to 70% of an ethanol aqueous solution; 0.5% to 2% of a surfactant; 0.1% to 0.5% of a citric acid-sodium citrate buffer pair; 0.01% to 0.1% of a complex of vitamin E and sodium sulfite; 0.02% to 0.03% of panthenol; 0.01% to 0.04% of hyaluronic acid; and 0.05% to 0.1% of a tea tree oil extract.

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