Anti-wrinkle whitening composition and preparation method thereof

Abstract

The invention relates to an anti-wrinkle whitening composition and a preparation method thereof, and belongs to the technical field of cosmetics, the composition comprises the following raw materials: composite peptide, hydroxypropyl tetrahydropyrantriol, a plant extract, vegetable oil, an emulsifier, a preservative and a solvent. According to the application, acetyl hexapeptide-7 and tripeptide-10 citrulline are selected as composite peptides, and the composite peptides, the Xixia lotus bulb extract and the hydroxypropyl tetrahydropyrantriol are compounded to serve as main anti-wrinkle components, so that different dimensions of reducing dynamic lines, increasing the collagen content and increasing the extracellular matrix content so as to assist in enhancing collagen deposition can be started; due to the synergistic effect, the finished product of the composition has an excellent anti-wrinkle effect; in addition, a patrinia scabiosaefolia extract, a pepperweed root extract, grape seed oil and a physalis alkekengi extract are combined for use, and the outstanding whitening effect is synergistically exerted from different dimensions of inhibiting melanocyte activity, reducing melanogenesis and reducing pigmentation.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to an anti-wrinkle and whitening composition and a preparation method thereof. Background Art

[0002] In the cosmetics industry, anti-wrinkle and whitening are two core needs that consumers have long focused on. With improved living standards and shifts in aesthetic standards, consumer demand for cosmetics that combine anti-wrinkle and whitening benefits is growing. However, the compositions currently used to prepare finished cosmetics on the market still have many shortcomings in terms of anti-wrinkle and whitening. Most existing anti-wrinkle compositions often rely on a single active ingredient, such as retinol or peptides, which can easily limit the amount added due to skin tolerance issues, resulting in slow and short-lived wrinkle improvement. Regarding whitening, many compositions focus solely on inhibiting melanin production, lacking effective intervention for existing melanin deposits, significantly reducing their whitening effectiveness.

[0003] Therefore, by rationally combining multiple active ingredients, a cosmetic composition that can effectively fight wrinkles and significantly whiten the skin is developed, which can effectively overcome the limitations of existing compositions in terms of anti-wrinkle and whitening effects and provide consumers with better cosmetic options. Summary of the Invention

[0004] The purpose of the present invention is to provide an anti-wrinkle and whitening composition and a preparation method thereof, which solves the problem that the anti-wrinkle and whitening effects of existing compositions used to prepare finished cosmetics are poor.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] The first aspect of the present invention provides an anti-wrinkle and whitening composition comprising the following raw materials in parts by weight:

[0007] 3-5.5 parts by weight of a composite peptide, 2-5 parts by weight of hydroxypropyl tetrahydropyrantriol, 8.2-12.3 parts by weight of a plant extract, 6-10 parts by weight of a vegetable oil, 5-10 parts by weight of an emulsifier, 0.1-0.5 parts by weight of a preservative, and 61-70 parts by weight of a solvent;

[0008] Hydroxypropyl tetrahydropyrantriol has the ability to increase the content of extracellular matrix and promote the synthesis of elastin and collagen.

[0009] As a preferred technical solution of the present invention, the composite peptide includes at least one of acetyl hexapeptide-1, acetyl hexapeptide-7, acetyl hexapeptide-8 and tripeptide-10 citrulline.

[0010] Preferably, the composite peptide comprises acetyl hexapeptide-7 and tripeptide-10 citrulline;

[0011] Acetyl hexapeptide-7 has the ability to stimulate keratinocyte proliferation and migration, while inducing collagen synthesis, which can effectively reduce the depth of dynamic lines;

[0012] Tripeptide-10 citrulline can further stabilize the extracellular matrix content increased by hydroxypropyl tetrahydropyrantriol and improve wrinkles, playing a certain auxiliary role.

[0013] Furthermore, the composite peptide comprises 2-4 parts by weight of acetyl hexapeptide-7 and 1-1.5 parts by weight of tripeptide-10 citrulline.

[0014] As a preferred technical solution of the present invention, the plant extracts include Leucophyllum aestivum bulb extract, Patrinia chrysantha extract, Leucanthemum officinale root extract and Physalis calyx extract;

[0015] Leucojum aestivum bulb extract has the ability to activate the TGF-β / Smad signaling pathway, thereby increasing collagen content;

[0016] The extract of Patrinia Scabiosaefolia contains ingredients such as Patrinene, Isopatrin, Scopolamine, Oleanolic Acid, and Quercetin, which can inhibit the activity of B-16 melanocytes and effectively reduce melanin content.

[0017] The root extract of Lepidium meyenii contains active ingredients such as fatty acids, phytosterols, and maca alkaloids, which have a certain inhibitory effect on tyrosinase and can block the melanin synthesis pathway;

[0018] Physalis ALKEKENGI calyx extract is rich in vitamin C, steroid compounds, sugar acid, sterols and other ingredients, which can reduce pigmentation, brighten skin tone, and make the skin whiter and more translucent.

[0019] Furthermore, the plant extract comprises 4-7 parts by weight of Leucophyllum aestivum bulb extract, 1-1.5 parts by weight of Patrinia chrysantha extract, 1.5-2 parts by weight of Leucophyllum mainianum root extract, and 1-2 parts by weight of Physalis calyx extract.

[0020] As a preferred technical solution of the present invention, the vegetable oil includes any one of grape seed oil, carrot seed oil and lemon peel oil.

[0021] Preferably, the vegetable oil comprises grape seed oil;

[0022] Grape (VITIS VINIFERA) seed oil contains polyphenols such as proanthocyanidins, fats, pantothenic acid and vitamins, which can speed up metabolism and prevent melanin deposition.

[0023] As a preferred technical solution of the present invention, the emulsifier includes at least one of cetyl alcohol, PEG-10 glyceryl stearate, and PEG-75 stearate, the preservative includes p-hydroxyacetophenone, and the solvent includes deionized water.

[0024] The second aspect of the present invention provides a method for preparing an anti-wrinkle and whitening composition, comprising the following steps:

[0025] S1, mixing the composite peptide, hydroxypropyl tetrahydropyrantriol and solvent under temperature control to obtain a mixture A;

[0026] S2, controlling the temperature and stirring the vegetable oil, emulsifier and preservative to obtain a mixture B;

[0027] S3. Add mixed material A to mixed material B, control the temperature and homogenize evenly, then cool down, add plant extract, mix and homogenize evenly, let it stand, and obtain the finished product of the composite material.

[0028] As a preferred technical solution of the present invention, the temperature of the temperature control in step S1 is 30-35°C.

[0029] As a preferred technical solution of the present invention, the temperature of the temperature control in step S2 is 35-40°C.

[0030] As a preferred technical solution of the present invention, the temperature of the temperature-controlled homogenization in step S3 is 80-85°C, the temperature of the cooling is 40-45°C, and the standing is standing to room temperature.

[0031] The third aspect of the present invention provides an anti-wrinkle and whitening composition for use in preparing cosmetics, wherein the anti-wrinkle and whitening composition is added at 3-5% of the total weight of the cosmetics.

[0032] As a preferred technical solution of the present invention, the cosmetics include but are not limited to toner, essence, cream and lotion.

[0033] Beneficial effects of the present invention:

[0034] (1) This application selects two peptides, Leucophyllum aestivum bulb extract and hydroxypropyl tetrahydropyrantriol as the main anti-wrinkle components, uses acetyl hexapeptide-7 to block nerve transmission of muscle signals and quickly reduce dynamic lines; uses Leucophyllum aestivum bulb extract to increase the content of collagen; at the same time, uses hydroxypropyl tetrahydropyrantriol in combination with tripeptide-10 citrulline to jointly increase the content of extracellular matrix and assist in enhancing the deposition of collagen. Therefore, the finished product of the composition prepared thereby has excellent anti-wrinkle effect.

[0035] (2) This application uses the extract of Patrinia scabra to inhibit the activity of B-16 melanocytes. At the same time, the root extract of Herba Lycoris Radiatae and grape seed oil are used in combination. The fatty acid chains in the root extract of Herba Lycoris Radiatae and the phenolic substances in the grape seed oil can synergistically regulate the NF-κB and Nrf2 / ARE pathways, enhance the antioxidant capacity of cells, reduce UV-induced melanin production and prevent melanin deposition to a certain extent. On this basis, the extract of Herba Lycoris Radiatae is also used to reduce pigment deposition and brighten the skin tone. Therefore, the finished product of the composition prepared in this way can synergistically exert outstanding whitening effects from the different dimensions of inhibiting melanocyte activity, reducing melanin production and reducing pigment deposition. DETAILED DESCRIPTION

[0036] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0037] The raw materials used in this application are all existing commercially available products. In detail, the summer leucophylla bulb extract, item number: xcsw20210331, was purchased from Ningxia Vanilla Biotechnology Co., Ltd.; the yellow flower patrinia extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd.; the main scutellaria root extract was purchased from Shanghai Boshuo Industrial Co., Ltd.; the calyx extract of the physalis was purchased from Fufeng Snow Biotechnology Co., Ltd.; the grape seed oil was purchased from Nanjing Bermuda Biotechnology Co., Ltd.; the above will not be repeated in the following.

[0038] Example 1

[0039] An anti-wrinkle and whitening composition comprising the following raw materials in parts by weight:

[0040] 4.2 parts by weight of a composite peptide, 2 parts by weight of hydroxypropyl tetrahydropyrantriol, 8.2 parts by weight of a plant extract, 8 parts by weight of a vegetable oil, 10 parts by weight of an emulsifier, 0.1 parts by weight of a preservative, and 67.5 parts by weight of a solvent;

[0041] The composite peptide comprises 3 parts by weight of acetyl hexapeptide-7 and 1.2 parts by weight of tripeptide-10 citrulline;

[0042] The plant extracts include 4 parts by weight of Leucophyllum aestivum bulb extract, 1.2 parts by weight of Patrinia chrysantha extract, 1.5 parts by weight of Leucophyllum mainianum root extract, and 1.5 parts by weight of Physalis calyx extract;

[0043] The vegetable oil includes grapeseed oil;

[0044] The emulsifier includes cetyl alcohol;

[0045] The preservative includes p-hydroxyacetophenone;

[0046] The solvent includes deionized water;

[0047] The preparation method of the anti-wrinkle and whitening composition comprises the following steps:

[0048] S1. Mix the composite peptide, hydroxypropyl tetrahydropyrantriol and solvent at a temperature of 32.5° C. to obtain a mixture A;

[0049] S2. Mix the vegetable oil, emulsifier and preservative at 40° C. with stirring to obtain a mixture B;

[0050] S3. Add mixed material A to mixed material B and homogenize at 80°C. Then cool to 45°C, add plant extract, mix and homogenize, and let stand to room temperature to obtain a finished composite material.

[0051] Example 2

[0052] An anti-wrinkle and whitening composition comprising the following raw materials in parts by weight:

[0053] 3 parts by weight of a composite peptide, 5 parts by weight of hydroxypropyl tetrahydropyrantriol, 12.3 parts by weight of a plant extract, 10 parts by weight of a vegetable oil, 7.5 parts by weight of an emulsifier, 0.3 parts by weight of a preservative, and 61.9 parts by weight of a solvent;

[0054] The composite peptide comprises 2 parts by weight of acetyl hexapeptide-7 and 1 part by weight of tripeptide-10 citrulline;

[0055] The plant extracts include 7 parts by weight of Leucophyllum aestivum bulb extract, 1.5 parts by weight of Patrinia chrysantha extract, 1.8 parts by weight of Leucophyllum mainianum root extract, and 2 parts by weight of Physalis calyx extract;

[0056] The vegetable oil includes grapeseed oil;

[0057] The emulsifier includes PEG-75;

[0058] The preservative includes p-hydroxyacetophenone;

[0059] The solvent includes deionized water;

[0060] The preparation method of the anti-wrinkle and whitening composition comprises the following steps:

[0061] S1. Mix the composite peptide, hydroxypropyl tetrahydropyrantriol and solvent at 30° C. to obtain a mixture A;

[0062] S2. Mix the vegetable oil, emulsifier and preservative at 35° C. with stirring to obtain a mixture B;

[0063] S3. Add mixed material A to mixed material B and homogenize at 82.5°C. Then cool to 42.5°C, add plant extract, mix and homogenize, and let stand to room temperature to obtain a finished composition.

[0064] Example 3

[0065] An anti-wrinkle and whitening composition comprising the following raw materials in parts by weight:

[0066] 5.5 parts by weight of a composite peptide, 3.5 parts by weight of hydroxypropyl tetrahydropyrantriol, 9.5 parts by weight of a plant extract, 6 parts by weight of a vegetable oil, 5 parts by weight of an emulsifier, 0.5 parts by weight of a preservative, and 70 parts by weight of a solvent;

[0067] The composite peptide comprises 4 parts by weight of acetyl hexapeptide-7 and 1.5 parts by weight of tripeptide-10 citrulline;

[0068] The plant extracts include 5.5 parts by weight of Leucophyllum aestivum bulb extract, 1 part by weight of Patrinia chrysantha extract, 2 parts by weight of Leucanthemum officinale root extract, and 1 part by weight of Physalis liliifolia extract;

[0069] The vegetable oil includes grapeseed oil;

[0070] The emulsifier includes PEG-10 glyceryl stearate;

[0071] The preservative includes p-hydroxyacetophenone;

[0072] The solvent includes deionized water;

[0073] The preparation method of the anti-wrinkle and whitening composition comprises the following steps:

[0074] S1. Mix the composite peptide, hydroxypropyl tetrahydropyrantriol and solvent at 35° C. to obtain a mixture A;

[0075] S2. Control the temperature at 37.5° C. and stir to mix the vegetable oil, emulsifier, and preservative to obtain a mixture B;

[0076] S3. Add mixed material A to mixed material B and homogenize at 85°C. Then cool to 40°C, add plant extract, mix and homogenize, and let stand to room temperature to obtain a finished composition.

[0077] Comparative Example 1

[0078] Compared with Example 2, the difference is that in Comparative Example 1, acetyl hexapeptide-7 is not added, and the missing weight is supplemented with tripeptide-10 citrulline, hydroxypropyl tetrahydropyrantriol, and Leucophyllum aestivum bulb extract in a mass ratio of 1:5:7, and the other operating steps and parameters remain unchanged.

[0079] Comparative Example 2

[0080] Compared with Example 2, the difference is that tripeptide-10 citrulline is not added in Comparative Example 2, and the missing weight is supplemented with acetyl hexapeptide-7, hydroxypropyl tetrahydropyrantriol, and Leucophyllum aestivum bulb extract in a mass ratio of 2:5:7. The other operating steps and parameters remain unchanged.

[0081] Comparative Example 3

[0082] Compared with Example 2, the difference is that in Comparative Example 3, hydroxypropyl tetrahydropyrantriol is not added, and the missing weight is supplemented with acetyl hexapeptide-7, tripeptide-10 citrulline, and Leucophyllum aestivum bulb extract in a mass ratio of 2:1:7, and the other operating steps and parameters remain unchanged.

[0083] Comparative Example 4

[0084] Compared with Example 2, the difference is that in Comparative Example 4, the extract of Leucophyllum aestivum bulb is not added, and the missing weight is supplemented with acetyl hexapeptide-7, tripeptide-10 citrulline, and hydroxypropyl tetrahydropyrantriol in a mass ratio of 2:1:5. The other operating steps and parameters remain unchanged.

[0085] Comparative Example 5

[0086] Compared with Example 2, the difference is that in Comparative Example 5, no Patrinia cava extract is added, and the missing weight is supplemented with Herba Lycopodii root extract, grape seed oil, and Physalis calyx extract in a mass ratio of 0.9:5:1, and the other operating steps and parameters remain unchanged.

[0087] Comparative Example 6

[0088] Compared with Example 2, the difference is that in Comparative Example 6, the extract of the root of Herba Myrindae was not added, and the missing weight was supplemented with the extract of Patrinia odorata, grape seed oil, and Physalis liliifolia in a mass ratio of 1.5:10:2, and the other operating steps and parameters remained unchanged.

[0089] Comparative Example 7

[0090] Compared with Example 2, the difference is that in Comparative Example 7, grape seed oil is not added, and the missing weight is supplemented with a Patrinia vulgaris extract, a Herba Lycopodii root extract, and a Herba Physalis calyx extract in a mass ratio of 1.5:1.8:2, and the other operating steps and parameters remain unchanged.

[0091] Comparative Example 8

[0092] Compared with Example 2, the difference is that in Comparative Example 8, no Physalis calyx extract is added, and the missing weight is supplemented with Patrinia scabra extract, Herba Lycopodii root extract, and grape seed oil in a mass ratio of 1.5:1.8:10, and the other operating steps and parameters remain unchanged.

[0093] Test Example 1: Anti-wrinkle effect test

[0094] The finished compositions prepared in Examples 1-3 and Comparative Examples 1-4 were added to the same essence matrix at 3% of the total essence mass to prepare essence samples. Healthy female volunteers aged 30-50 years with similar facial wrinkle severity were randomly divided into 7 groups of 12 participants each, with each group testing one sample. The samples were then applied to the wrinkle areas of the subjects' cheeks. The subjects applied 1 mL of the corresponding essence from each group evenly to the wrinkle areas and massaged until completely absorbed. This was done once in the morning and evening for 28 consecutive days. The number of wrinkles and the degree of wrinkle area reduction in the subjects' cheek wrinkle areas were measured using an Antera 3D Skin Analyzer. The values ​​for each group were averaged, and the results are shown in Table 1.

[0095] Table 1

[0096]

[0097] As can be seen from Table 1, the finished composition prepared in this application has excellent anti-wrinkle effects. This is because the application uses acetyl hexapeptide-7 and tripeptide-10 citrulline as the composite peptides, together with Leucophyllum aestivum bulb extract and hydroxypropyl tetrahydropyrantriol as the main anti-wrinkle components. They can reduce dynamic wrinkles, increase collagen content, increase extracellular matrix content, and thus assist in enhancing collagen deposition. The synergistic effect makes the finished composition have excellent anti-wrinkle effects.

[0098] Test Example 2: Whitening Efficacy Test

[0099] Determination of tyrosinase inhibition rate: Use a 10 mL test tube to set up a sample tube (T2), a sample background (T1), an enzyme reaction tube (C2), and a solvent background (C1). For each sample and each tested concentration, three parallel tubes need to be set up for the sample tube (T2) and enzyme reaction tube (C2). The finished compositions prepared in Examples 1-3 and Comparative Examples 5-8 were added as sample solutions according to Table 2 and mixed thoroughly. The mixture was then placed in a 37°C water bath and incubated for 10 minutes. 2 mL of levodopa solution was added to each tube in turn. The reaction time for each tube was controlled to 5 minutes. The reaction solution in each tube was immediately transferred to a cuvette, and the absorbance was measured at 475 nm. The tyrosinase inhibition rate of the finished composition was calculated according to the following formula:

[0100] Tyrosinase inhibition rate (%) = 1-[(AT2 -A T1 ) / A C2 -A C1 )];

[0101] Table 2 Sample addition requirements

[0102]

[0103] The results are shown in Table 3.

[0104] Table 3

[0105]

[0106] As can be seen from Table 3, the finished composition prepared in this application has an outstanding whitening effect. This is because the present application uses Patrinia vulgaris extract, Herba Menthae root extract, grape seed oil, and Physalis calyx extract, which can synergistically exert an outstanding whitening effect from different dimensions: inhibiting melanocyte activity, reducing melanin production, and reducing pigmentation.

[0107] Throughout the specification, references to terms such as "one embodiment," "example," or "specific example" indicate that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0108] The above content is merely an example and explanation of the concept of the present invention. Those skilled in the art may make various modifications or additions to the described specific embodiments or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the scope of protection of the present invention.

Claims

1. An anti-wrinkle and whitening composition, characterized in that: It includes the following raw materials in parts by weight: 3-5.5 parts by weight of complex peptide, 2-5 parts by weight of hydroxypropyl tetrahydropyrantriol, 8.2-12.3 parts by weight of plant extract, 6-10 parts by weight of vegetable oil, 5-10 parts by weight of emulsifier, 0.1-0.5 parts by weight of preservative, and 61-70 parts by weight of solvent.

2. The anti-wrinkle and whitening composition according to claim 1, characterized in that The composite peptide comprises at least one of acetyl hexapeptide-1, acetyl hexapeptide-7, acetyl hexapeptide-8 and tripeptide-10 citrulline; preferably, the composite peptide comprises acetyl hexapeptide-7 and tripeptide-10 citrulline.

3. The anti-wrinkle and whitening composition according to claim 2, characterized in that: The composite peptide comprises 2-4 parts by weight of acetyl hexapeptide-7 and 1-1.5 parts by weight of tripeptide-10 citrulline.

4. The anti-wrinkle and whitening composition according to claim 1, characterized in that The plant extracts include Leucophyllum aestivum bulb extract, Patrinia chrysantha extract, Leucanthemum officinale root extract and Physalis liliifolia extract.

5. The anti-wrinkle and whitening composition according to claim 4, characterized in that: The plant extracts include 4-7 parts by weight of Leucophyllum aestivum bulb extract, 1-1.5 parts by weight of Patrinia chrysantha extract, 1.5-2 parts by weight of Leucophyllum mainianum root extract, and 1-2 parts by weight of Physalis calyx extract.

6. The anti-wrinkle and whitening composition according to claim 1, characterized in that: The vegetable oil includes any one of grape seed oil, carrot seed oil and lemon peel oil; preferably, the vegetable oil includes grape seed oil.

7. The anti-wrinkle and whitening composition according to claim 1, characterized in that: The emulsifier includes at least one of cetyl alcohol, PEG-10 glyceryl stearate, and PEG-75 stearate; the preservative includes p-hydroxyacetophenone; and the solvent includes deionized water.

8. A method for preparing the anti-wrinkle and whitening composition according to any one of claims 1 to 7, characterized in that: The steps include: S1, mixing the composite peptide, hydroxypropyl tetrahydropyrantriol and solvent under temperature control to obtain a mixture A; S2, controlling the temperature and stirring the vegetable oil, emulsifier and preservative to obtain a mixture B; S3. Add mixed material A to mixed material B, control the temperature and homogenize evenly, then cool down, add plant extract, mix and homogenize evenly, let it stand, and obtain the finished product of the composite material.

9. The method for preparing the anti-wrinkle and whitening composition according to claim 8, wherein: The temperature of the temperature control in step S1 is 30-35°C; the temperature of the temperature control in step S2 is 35-40°C.

10. The method for preparing the anti-wrinkle and whitening composition according to claim 8, wherein: In step S3, the temperature of the temperature-controlled homogenization is 80-85° C., the temperature of the cooling is 40-45° C., and the standing is standing to room temperature.

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