Liquid phase chip detection equipment

Abstract

The invention relates to the field of liquid-phase chips, particularly discloses liquid-phase chip detection equipment, and aims to solve the problems that the number of sampling tubes is inconvenient to flexibly switch and adjust during sampling of existing liquid-phase chip detection equipment, and meanwhile, after sampling, sample liquid in the sampling tubes drips to pollute other samples. The device comprises a device body, a sample bin, a pore plate frame, a sampling frame, a direction adjusting assembly, a variable frequency motor, a rotating base, a first rotating shaft, an electric control sampling pipe, a control assembly, a frame, a second rotating shaft, an anti-dripping cover, a limiting table, a second gear, a sliding frame, a second rack, a transverse plate and a cleaning box. The cleaning box is driven to be started to the lower part so as to clean the electric control sampling pipe. The equipment can flexibly switch and adjust the use number of the sampling pipes, can effectively avoid pollution caused by dropping of sample liquid in the sampling pipes after sampling, and is convenient to clean the sampling pipes.

Description

Technical Field

[0001] The present invention relates to the field of liquid phase chips, in particular to a liquid phase chip detection device. Background Art

[0002] Liquid-phase chip detection equipment is an analytical instrument used in fields such as chemistry, biology, and clinical medicine. It utilizes dual-fluorescence labeling of microspheres and liquid-dispersed laser automated detection technology to automatically perform multi-channel, high-throughput analysis of nucleic acids, enzymes, receptors, antibodies, and antigens. The core technology of the liquid-phase chip detection equipment is the patented xMAP coded microsphere system. Using unique microsphere surface chemistry, different probe molecules are labeled on the microspheres, each corresponding to a specific target molecule. When the microbeads, coupled with specific antibodies, react with proteins in the sample, biotin-labeled detection antibodies are added, and the signal is amplified by linking PE-labeled streptavidin to the biotin. During detection, the microbeads rapidly pass through the liquid flow system through a first red laser beam to identify the microbeads. A second green laser beam detects the intensity of the PE fluorescence signal. Finally, the optical signal is rapidly processed into a digital signal, which is analyzed by software to calculate the content of each protein.

[0003] However, existing liquid chip detection equipment generally uses 96-well plates or 384-well plates, and is equipped with a sampling head with 4 or 8 sampling tubes for sampling. Regardless of whether 4 or 8 sampling tubes are used, neither can be flexibly adjusted and switched, and the sampling rate cannot be conveniently adjusted.

[0004] The authorization announcement number is CN113985048B, which discloses a liquid chip detection device, which relates to the field of biochip detection technology, including a loading mechanism, a pipetting mechanism, a collection mechanism, a detection area and a detection device. The loading mechanism is used to detachably load the reagent card, the pipetting mechanism is used to transfer the sample from the sample position for accommodating the sample to the reaction position for providing a reaction site, transfer the reagent from the reagent position to the reaction position, and remove the reacted solution from the reaction position. The sample and the reagent react at the reaction position and obtain the particles to be analyzed, and the collection mechanism is used to collect the particles to be analyzed. The detection area includes a microfluidic detection area or a fixed detection area, the light source is used to irradiate the particles in the detection area, and the detection device is used to detect the light signal emitted by each particle. Due to the addition of the pipetting mechanism and the collection mechanism, the manual operation steps of the liquid chip detection equipment are reduced, which is conducive to reducing the labor intensity of the operator and reducing the errors caused by manual operation.

[0005] While the above technical solution can reduce manual operation steps, it still cannot flexibly adjust the number of sampling tubes used, nor can it flexibly switch and control them during the specific sampling process. In addition, the existing sampling tubes have the risk of dripping after sampling, which can easily cause the sampling solution to drip into other areas of the well plate and contaminate samples in other areas of the well plate. Therefore, a liquid chip detection device is proposed. Summary of the Invention

[0006] In order to overcome the shortcomings of the existing technology, the present invention proposes a liquid chip detection device that can flexibly switch and control the number of sampling tubes used, and can effectively prevent the sample in the sampling tube from dripping after sampling is completed, thereby contaminating the samples contained in other areas of the well plate.

[0007] In order to solve the above technical problems, the basic technical solutions proposed by the present invention are: A liquid chip detection device comprises a device body and a sample chamber, a well plate rack is installed at the bottom of the sample chamber, a sampling frame is slidably arranged in the sample chamber, an azimuth adjustment component is provided in the sample chamber, the azimuth adjustment component is used to adjust the azimuth and height of the sampling frame, frequency conversion motors are installed on both sides of the inner wall of the sampling frame, the frequency conversion motors on both sides are close to each other and a rotating seat is installed on one side of the output end, two mutually parallel rotating shafts 1 are rotatably connected between the rotating seats on both sides, a plurality of electrically controlled sampling tubes are evenly spaced and installed on each of the rotating shafts 1, a control component is provided on the rotating seat, the control component is used to control the rotation of the two rotating shafts 1 to control the number of electrically controlled sampling tubes used during sampling, and a frame is connected to the front side of the sampling frame; The frame is rotatably connected to a rotating shaft 2 via a spring hinge, and a drip-proof cover is connected to the rotating shaft 2. The frame is connected to a limit platform for limiting the drip-proof cover. Gear 2 is provided at both ends of the rotating shaft 2. A slide is also slidably provided on the frame, and a rack 2 meshing with gear 2 is connected to the slide. A horizontal plate that interferes with the inner wall of the sample chamber is connected to the slide. A cleaning box is slidably provided in the sample chamber, and a linkage component is also provided in the sample chamber. The linkage component is used to drive the cleaning box to start below the sampling frame when the sampling frame moves upward to clean the electronically controlled sampling tube.

[0008] Preferably, the sample chamber is opened on one side of the device body, and an electric control display screen is installed on the other side of the device body.

[0009] Preferably, the orientation adjustment assembly includes an x-axis slide rail, an upper telescopic member, a y-axis slide rail, and a lower telescopic member, the x-axis slide rail is installed on the upper inner wall of the sample chamber, the upper end of the upper telescopic member is slidably connected in the x-axis slide rail, the y-axis slide rail is installed at the lower output end of the upper telescopic member, the upper end of the lower telescopic member is slidably connected in the y-axis slide rail, and the sampling frame is connected to the lower output end of the lower telescopic member.

[0010] Preferably, the upper ends of the upper telescopic member and the lower telescopic member are connected to guide blocks, and are slidably connected to the x-axis slide rail and the y-axis slide rail through the guide blocks respectively. The lower end of the y-axis slide rail is connected to the top frame, and the upper end of the horizontal plate and the lower end of the top frame cooperate and slide in contact.

[0011] Preferably, the two ends of the second rotating shaft rotate and extend through the two sides of the frame, and gear two is installed on the extended ends on both sides. The slide slides through the upper and lower sides of the frame, and a spring two is installed on the outside of the slide and connected between the upper end of the slide and the frame.

[0012] Preferably, the control assembly includes a gear, a guide rod frame, a rack, an arc block, and an arc frame. The gear is mounted on both ends of each rotating shaft, the guide rod frame is connected to the side where the rotating seats on both sides are close to each other, one end of the rack is slidably mounted on the outside of the guide rod frame, and the other end extends between the gears on the two rotating shafts and is meshed with the gears on both sides. A spring is connected between the rack and the guide rod frame, the arc block is connected to the end of the rack away from the guide rod frame, the arc frame is connected to the sampling frame, and the arc block is slidably connected in the arc frame.

[0013] Preferably, a guide slide is provided on the rack, a guide block is connected to the rotating seat, and the guide block is slidably sleeved in the guide slide, and the rotating seats on both sides are connected to connecting plates on the side close to each other, and the arc frame is connected to the end of the connecting plates on both sides close to each other.

[0014] The lifting mechanism is connected with the lifting mechanism, and the lifting mechanism is connected with the lifting mechanism of the lifting mechanism were connected with the lifting mechanism, and the lifting mechanism is connected with the lifting mechanism of the lifting mechanism are connected with the lifting mechanism.

[0015] Preferably, a plurality of cleaning holes are arranged in an array on the upper end surface of the cleaning box, each of the cleaning holes is equipped with a detergent nozzle, a brush and an emptying channel, and the electrically controlled sampling tube is slidably inserted into the cleaning hole.

[0016] Preferably, limit slide bars are installed on both sides of the upper inner wall of the sample bin, the pull seat sliding sleeve is arranged on the outer side of the limit slide bar, and a spring four is connected between the pull seat and the upper inner wall of the sample bin.

[0017] The beneficial effects of the present invention are: 1. The technical solution of the present invention can drive the rotating seat to rotate by controlling the operation of the variable frequency motor, so that the rotating seat can drive the rack 1 sliding thereon to rotate along with it during the rotation process, and then the arc block connected to one end of the rack 1 will slide in the arc frame and come into conflict with the inner wall of the arc frame, so that the rack 1 can slide relative to the rotating shaft 1 on both sides, and through engagement with the gear 1, drive the electric control sampling tubes on the two sides of the rotating shaft 1 that were originally 180 degrees apart to approach each other and rotate to 0 degrees. During the process, the electric control sampling tubes originally facing upwards are also rotated to face downwards, so that the electric control sampling tubes installed on the two rotating shafts 1 can both face downwards and be used at the same time, forming multiple electric control sampling tubes for joint sampling, thereby improving sampling efficiency. When the electric control sampling tubes installed on the two rotating shafts 1 are 180 degrees apart from each other, only the electric control sampling tube on one rotating shaft is used for sampling, which greatly facilitates the adjustment of the use of the electric control sampling tubes. 2. The technical solution of the present invention can drive the sampling frame to move upward after sampling is completed through the contraction cooperation of the upper telescopic member and the lower telescopic member, until the slide sliding in the upper frame moves upward, and the horizontal plate connected to the slide moves up to contact the top frame. At this time, the slide can be pushed downward relative to the frame, and the rack second can be driven downward. The engagement of the rack second and the gear second drives the rotation shaft second to rotate, so that the drip-proof cover can overcome the elastic force of the spring hinge and rotate to the lower side of the electric-controlled sampling tube to block the lower side of the electric-controlled sampling tube, thereby avoiding the risk of dripping and contamination of the sample liquid in the electric-controlled sampling tube; 3. The technical solution of the present invention drives the lower telescopic member and the sampling frame to the rear end of the sample chamber through the Y-axis slide rail, and controls the extension and coordination of the upper telescopic member and the lower telescopic member, so that the side seats on both sides of the sampling frame can move to the lower side of the pulling seat. After the electric-controlled sampling tube completes sampling and pipetting, the sampling frame is controlled to move upward, and the rotating plate is pulled by the pulling seat to rotate, thereby driving the lower seat to move directly below the sampling frame. At the same time, according to the rotation of the rotating seat, when the electric-controlled sampling tubes on the two rotating shafts are both facing downward, the rotating seat will not interfere with the T-shaped top plate, and the cleaning box can also be directly below the sampling frame and clean each electric-controlled sampling tube through the cleaning hole. When the electric-controlled sampling tubes on the two rotating shafts are 180 degrees to each other, only one side of the electric-controlled sampling tube is facing downward. At this time, one end of the rotating seat will interfere with the T-shaped top plate, causing the cleaning box to slide and push a row of the two cleaning holes opened on the cleaning box to directly below the sampling frame to achieve precise coordinated cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of the present invention; Figure 2 This is a schematic diagram of the internal structure of the sample chamber of the present invention; Figure 3 It is a rear view schematic diagram of the internal structure of the sample chamber of the present invention; Figure 4 It is a schematic diagram of the orientation adjustment component, sampling frame and related structures on the cleaning box of the present invention; Figure 5 This is a schematic structural diagram of the sampling frame, cleaning box and linkage assembly of the present invention; Figure 6 It is a schematic diagram of the relevant structure of the cleaning box of the present invention; Figure 7 A schematic diagram of the relevant structures on the sampling frame of the present invention; Figure 8 Schematic diagram of the relevant structures in the sampling frame of the present invention.

[0019] Description of reference numerals: 1. Equipment body; 2. Sample chamber; 3. Electronically controlled display screen; 4. Orifice plate rack; 5. X-axis slide rail; 6. Upper telescopic member; 7. Y-axis slide rail; 8. Lower telescopic member; 9. Guide block; 10. Sampling frame; 11. Frequency conversion motor; 12. Rotating seat; 13. Rotating shaft 1; 14. Electronically controlled sampling tube; 15. Gear 1; 16. Guide rod rack; 17. Rack 1; 18. Spring 1; 19. Guide slide; 20. Guide block; 21. Arc block; 22. Connecting plate; 23. Arc frame; 2 4. Frame; 25. Second rotating shaft; 26. Drip shield; 27. Horizontal plate; 28. Second gear; 29. ​​Slide; 30. Second rack; 31. Second spring; 32. Limiting platform; 33. Top frame; 34. Side seat; 35. Slide rail; 36. Lower slide seat; 37. Slide rod frame; 38. Upper slide seat; 39. Third spring; 40. Electric telescopic rod; 41. Cleaning box; 42. Cleaning hole; 43. T-shaped top plate; 44. Rotating plate; 45. Pull seat; 46. Limiting slide; 47. Fourth spring. DETAILED DESCRIPTION

[0020] The following will be combined with the Figure 1 To the attached Figure 8 The technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without inventive effort shall fall within the scope of protection of the present invention.

[0021] Example 1:

[0022] like Figures 1-8As shown, the present invention discloses a liquid chip detection device, including a device body 1, a sample chamber 2, a well plate rack 4 is installed at the bottom of the sample chamber 2, a sampling frame 10 is slidably arranged in the sample chamber 2, an azimuth adjustment component is provided in the sample chamber 2, the azimuth adjustment component is used to adjust the azimuth and height of the sampling frame 10, and frequency conversion motors 11 are installed on both sides of the inner wall of the sampling frame 10, and the frequency conversion motors 11 on both sides are close to each other. The output end of each side is installed with a rotating seat 12, and two mutually parallel rotating shafts 13 are rotatably connected between the rotating seats 12 on both sides, and a plurality of electrically controlled sampling tubes 14 are evenly spaced and installed on each rotating shaft 13. A control component is provided on the rotating seat 12, and the control component is used to control the rotation of the two rotating shafts 13 to control the number of electrically controlled sampling tubes 14 used during sampling. The front side of the sampling frame 10 is connected to a frame 24; A second rotating shaft 25 is rotatably connected to the frame 24 through a spring hinge, and a drip-proof cover 26 is connected to the second rotating shaft 25. A limit platform 32 for limiting the drip-proof cover 26 is connected to the frame 24. Gear 28 is provided at both ends of the second rotating shaft 25. A slide 29 is also slidably provided on the frame 24. The slide 29 is connected to a rack 2 30 meshing with the second gear 28. The slide 29 is connected to a horizontal plate 27 that contacts the inner wall of the sample chamber 2. A cleaning box 41 is slidably provided in the sample chamber 2. A linkage component is also provided in the sample chamber 2. The linkage component is used to drive the cleaning box 41 to start to the bottom of the sampling frame 10 when it moves upward to clean the electronically controlled sampling tube 14.

[0023] The sample chamber 2 is opened on one side of the device body 1 , and an electric control display screen 3 is installed on the other side of the device body 1 . The electric control display screen 3 is convenient for directly controlling the device body 1 .

[0024] The two ends of the second rotating shaft 25 rotate and extend through the two sides of the frame 24, and the two gears 28 are installed on the extended ends on both sides. The slide 29 slides through the upper and lower sides of the frame 24. The upper end of the slide 29 is connected to the frame 24 with a second spring 31 installed on the outside of the slide 29, so that under the elastic force of the second spring 31, the slide 29 can move up to the top of the frame 24.

[0025] Example 2:

[0026] like Figures 1-8 As shown, the present invention discloses a liquid chip detection device. Compared with the first embodiment, this embodiment discloses the structure of the orientation adjustment component.

[0027] The azimuth adjustment assembly includes an x-axis slide rail 5, an upper telescopic member 6, a y-axis slide rail 7, and a lower telescopic member 8. The x-axis slide rail 5 is installed on the upper inner wall of the sample chamber 2, the upper end of the upper telescopic member 6 is slidably connected in the x-axis slide rail 5, the y-axis slide rail 7 is installed at the lower output end of the upper telescopic member 6, the upper end of the lower telescopic member 8 is slidably connected in the y-axis slide rail 7, and the sampling frame 10 is connected to the lower output end of the lower telescopic member 8.

[0028] The upper ends of the upper telescopic member 6 and the lower telescopic member 8 are connected to the guide blocks 9, and are respectively slidably connected to the x-axis slide rail 5 and the y-axis slide rail 7 through the guide blocks 9. The lower end of the y-axis slide rail 7 is connected to the top frame 33, and the upper end of the cross plate 27 and the lower end of the top frame 33 cooperate and slide in contact.

[0029] The upper telescopic member 6 can be controlled to slide left and right in the sample chamber 2 by the x-axis slide 5, the lower telescopic member 8 can be controlled to slide back and forth in the sample chamber 2 by the y-axis slide 7, and the sampling frame 10 can be driven to move up and down in the sample chamber 2 through the telescopic cooperation of the upper telescopic member 6 and the lower telescopic member 8, thereby realizing the flexible adjustment of the orientation position of the sampling frame 10 and the electrically controlled sampling tube 14 installed therein in the sample chamber 2.

[0030] Example 3:

[0031] like Figures 1-8 As shown, the present invention discloses a liquid phase chip detection device. Compared with the second embodiment, this embodiment discloses the structure of the control component.

[0032] The control assembly includes a gear 15, a guide rod frame 16, a rack 17, an arc block 21, and an arc frame 23. The gear 15 is mounted on both ends of each rotating shaft 13. The guide rod frame 16 is connected to the side of the rotating seats 12 on both sides close to each other. One end of the rack 17 is slidably mounted on the outside of the guide rod frame 16, and the other end extends between the gears 15 on the two rotating shafts 13 and is meshed with the gears 15 on both sides. A spring 18 is connected between the rack 17 and the guide rod frame 16 and is mounted on the outside of the guide rod frame 16. The arc block 21 is connected to the end of the rack 17 away from the guide rod frame 16. The arc frame 23 is connected to the sampling frame 10, and the arc block 21 is slidably connected in the arc frame 23.

[0033] The arc frame 23 is an irregular arc shape, with its side end away from the rotating seat 12 and the lower end close to the rotating seat 12, so that when the rotating seat 12 rotates and drives the arc block 21 to slide therein, it can drive the rack 17 to be pushed to slide on the guide rod frame 16 and compress the spring 18. When the electric control sampling tubes 14 installed on the upper and lower rotating shafts 13 are 180 degrees apart, the arc block 21 is at the side end of the arc frame 23, and then when the rotating seat 12 is driven to rotate by the frequency conversion motor 11, it can drive the arc block 21 to slide from the side end of the arc frame 23 to the lower end. During the process, the arc block 21 will drive the rack 17 to slide, and through engagement with the gear 15, drive the electric control sampling tubes 14 installed on the two rotating shafts 13 to rotate close to each other to a state of 0 degrees and facing downward, so as to facilitate sampling and also facilitate adjustment of the number of electric control sampling tubes 14 used for specific sampling.

[0034] Furthermore, the rotating seat 12 is actually a disc with a protrusion at one end. When the two electrically controlled sampling tubes 14 on the rotating shaft 13 are at 0° to each other, the protrusion side is facing upward and is located in the sampling frame 10. When the two electrically controlled sampling tubes 14 on the rotating shaft 13 are at 180° to each other, the protrusion side is facing the side away from the orifice plate rack 4.

[0035] A guide slide 19 is provided on the rack 17, and a guide block 20 is connected to the rotating seat 12, and the guide block 20 is slidably sleeved in the guide slide 19. The rotating seats 12 on both sides are connected to the side close to each other, and the arc frame 23 is connected to the end of the connecting plates 22 on both sides that are close to each other. This arrangement allows the rack 17 to slide more stably on the rotating seat 12 when the arc block 21 pushes the rack 17 to slide.

[0036] By controlling the frequency conversion motor 11 to operate, the rotating seat 12 can be driven to rotate, so that during the rotation of the rotating seat 12, the rack 17 sliding thereon can be driven to rotate accordingly, and then the arc block 21 connected to one end of the rack 17 will slide in the arc frame 23 and come into conflict with the inner wall of the arc frame 23, so that the rack 17 slides relative to the rotating shaft 13 on both sides, and through the engagement with the gear 15, drives the electric control sampling tube 1 on both sides of the rotating shaft 13, which was originally at 180 degrees. 4 are rotated close to each other to 0°. During the process, the electric-controlled sampling tube 14 originally facing upward is also rotated to face downward, so that the electric-controlled sampling tubes 14 installed on the two rotating shafts 13 can all face downward and be used at the same time, forming multiple electric-controlled sampling tubes 14 for joint sampling, thereby improving the sampling efficiency. When the electric-controlled sampling tubes 14 installed on the rotating shafts 13 on both sides are 180° apart from each other, only the electric-controlled sampling tube 14 on the rotating shaft 13 is used for sampling, which greatly facilitates the adjustment of the use of the electric-controlled sampling tubes 14.

[0037] Example 4:

[0038] like Figures 1-8 As shown, the present invention discloses a liquid chip detection device. Compared with the third embodiment, this embodiment discloses the structure of a linkage component.

[0039] The linkage assembly includes a side seat 34, a slide rail 35, a lower slide seat 36, a slide rod frame 37, an upper slide seat 38, an electric telescopic rod 40, a T-shaped top plate 43, and a pull seat 45. The side seat 34 is connected to both sides of the sampling frame 10, the slide rail 35 is connected to the lower inner wall of the sample chamber 2, the lower slide seat 36 is slidably connected to the slide rail 35, the slide rod frame 37 is connected to the lower slide seat 36, and the upper slide seat 38 is slidably sleeved on the outer side of the slide rod frame 37, and the upper slide seat 38 is connected to the slide rod frame 37. There is a spring 39 sleeved on the outside of the slide rack 37, the electric telescopic rod 40 is connected to both sides of the upper slide 38, the cleaning box 41 is connected to the upper output end of the two electric telescopic rods 40, the T-shaped top plate 43 is connected to the side of the cleaning box 41 away from the orifice plate rack 4, and cooperates with the rotating seat 12, the pull seat 45 is slidably set in the sample chamber 2, and is rotatably connected to the lower slide seat 36 with a rotating plate 44, and the upper end surface of the side seat 34 cooperates with the lower end surface of the pull seat 45.

[0040] A plurality of cleaning holes 42 are arranged in an array on the upper end surface of the cleaning box 41. A cleaning agent nozzle, a brush and an emptying channel are installed in each cleaning hole 42. The electric-controlled sampling tube 14 is slidably inserted into the cleaning hole 42, so that each electric-controlled sampling tube 14 can be inserted into its respective cleaning hole 42 for cleaning.

[0041] Limit slide bars 46 are installed on both sides of the upper inner wall of the sample chamber 2, and the pull seat 45 is slidably sleeved on the outer side of the limit slide bar 46. A spring four 47 is connected between the pull seat 45 and the upper inner wall of the sample chamber 2, so that the pull seat 45 can slide more stably in the sample chamber 2, and in the absence of external force, the pull seat 45 will move downward under the elastic force of the spring four 47 until it contacts the lower end of the limit slide bar 46 and stops.

[0042] Specifically, when in use, the Y-axis slide rail 7 is controlled to drive the lower telescopic member 8 and the sampling frame 10 to move to the rear end of the sample chamber 2, and the upper telescopic member 6 is controlled to extend and cooperate with the lower telescopic member 8, so that the side seats 34 on both sides of the sampling frame 10 can move to the lower side of the pull seat 45. After the electronically controlled sampling tube 14 completes sampling and pipetting, the sampling frame 10 is controlled to move upward, and the rotating plate 44 is pulled to rotate by the pull seat 45, thereby driving the lower seat 36 to move to the bottom of the sampling frame 10. At the same time, according to the rotation of the rotating seat 12, when the electronically controlled sampling tubes 14 on the two rotating shafts 13 are all facing downward, the rotating seat 12 will not conflict with the T-shaped top plate 43, and the cleaning box 41 can also be in The cleaning box 41 is directly below the sampling frame 10, and each electric-controlled sampling tube 14 is cleaned through the cleaning hole 42. When the electric-controlled sampling tubes 14 on the two rotating shafts 13 are 180 degrees to each other, only the electric-controlled sampling tube 14 on one side is facing downward. At this time, one end of the rotating seat 12 will conflict with the T-shaped top plate 43, causing the cleaning box 41 to slide and push a row of the two cleaning holes 42 opened on the cleaning box 41 to directly below the sampling frame 10 to achieve precise matching cleaning, ensuring that no matter whether the electric-controlled sampling tube 14 on one rotating shaft 13 or the electric-controlled sampling tubes 14 on both rotating shafts 13 are used, efficient and precise alignment cleaning can be performed.

[0043] Based on the disclosure and teachings of the above description, those skilled in the art may also make changes and modifications to the above embodiments. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and modifications and variations of the present invention should also fall within the scope of protection of the claims of the present invention. In addition, although certain specific terms are used in this description, these terms are only for convenience of description and do not constitute any limitation to the present invention.

Claims

1. A liquid phase chip detection device, comprising a device body (1), a sample chamber (2), a well plate rack (4) installed at the bottom of the sample chamber (2), characterized in that: A sampling frame (10) is slidingly provided in the sample chamber (2), and an orientation adjustment component is provided in the sample chamber (2), and the orientation adjustment component is used to adjust the orientation and height of the sampling frame (10). Frequency conversion motors (11) are installed on both inner walls of the sampling frame (10), and rotating seats (12) are installed on the output ends of the frequency conversion motors (11) on both sides close to each other. Two mutually parallel rotating shafts (13) are rotatably connected between the rotating seats (12) on both sides, and a plurality of electrically controlled sampling tubes (14) are evenly spaced and installed on each rotating shaft (13). A control component is provided on the rotating seat (12), and the control component is used to control the rotation of the two rotating shafts (13) to control the number of electrically controlled sampling tubes (14) used during sampling. The front side of the sampling frame (10) is connected to a frame (24); The frame (24) is rotatably connected to a second rotating shaft (25) via a spring hinge, and a drip shield (26) is connected to the second rotating shaft (25). The frame (24) is connected to a limit table (32) for limiting the drip shield (26). Both ends of the second rotating shaft (25) are provided with a second gear (28). The frame (24) is also slidably provided with a slide (29), and the slide (29) is connected to a second rack (30) meshing with the second gear (28). The slide (29) is connected to a horizontal plate (27) that contacts the inner wall of the sample chamber (2). A cleaning box (41) is slidably provided in the sample chamber (2). A linkage component is also provided in the sample chamber (2). The linkage component is used to drive the cleaning box (41) to start to the bottom thereof when the sampling frame (10) moves upward, so as to clean the electronically controlled sampling tube (14).

2. A liquid phase chip detection device according to claim 1, characterized in that: The sample chamber (2) is opened on one side of the device body (1), and an electric control display screen (3) is installed on the other side of the device body (1).

3. The liquid phase chip detection device according to claim 1, characterized in that: The orientation adjustment assembly comprises an x-axis slide rail (5), an upper telescopic member (6), a y-axis slide rail (7), and a lower telescopic member (8); the x-axis slide rail (5) is mounted on the upper inner wall of the sample chamber (2); the upper end of the upper telescopic member (6) is slidably connected in the x-axis slide rail (5); the y-axis slide rail (7) is mounted on the lower output end of the upper telescopic member (6); the upper end of the lower telescopic member (8) is slidably connected in the y-axis slide rail (7); and the sampling frame (10) is connected to the lower output end of the lower telescopic member (8).

4. The liquid phase chip detection device according to claim 3, characterized in that: The upper ends of the upper telescopic member (6) and the lower telescopic member (8) are both connected to a guide block (9), and are respectively slidably connected to the x-axis slide rail (5) and the y-axis slide rail (7) through the guide block (9); the lower end of the y-axis slide rail (7) is connected to a top frame (33), and the upper end of the horizontal plate (27) and the lower end of the top frame (33) are in sliding contact with each other.

5. The liquid phase chip detection device according to claim 1, characterized in that: The two ends of the second rotating shaft (25) rotate and extend through the two sides of the frame (24), and the two gears (28) are mounted on the extended ends on both sides. The slide (29) slides through the upper and lower sides of the frame (24), and the upper end of the slide (29) and the frame (24) are connected to the second spring (31) mounted on the outside of the slide (29).

6. The liquid phase chip detection device according to claim 1, characterized in that: The control component includes a gear one (15), a guide rod frame (16), a rack one (17), an arc block (21), and an arc frame (23). The gear one (15) is mounted on both ends of each rotating shaft one (13). The guide rod frame (16) is connected to the side of the rotating seats (12) on both sides close to each other. One end of the rack one (17) is slidably mounted on the outside of the guide rod frame (16), and the other end extends between the gears one (15) on the two rotating shafts one (13) and is meshed with the gears one (15) on both sides. A spring one (18) mounted on the outside of the guide rod frame (16) is connected between the rack one (17) and the guide rod frame (16). The arc block (21) is connected to the end of the rack one (17) away from the guide rod frame (16). The arc frame (23) is connected to the sampling frame (10), and the arc block (21) is slidably connected in the arc frame (23).

7. The liquid phase chip detection device according to claim 6, characterized in that: A guide slideway (19) is provided on the rack (17), a guide block (20) is connected to the rotating seat (12), and the guide block (20) is slidably sleeved in the guide slideway (19), and the rotating seats (12) on both sides are connected to the side close to each other with a connecting plate (22), and the arc frame (23) is connected to the end of the connecting plates (22) on both sides close to each other.

8. The liquid phase chip detection device according to claim 1, characterized in that: The linkage assembly includes a side seat (34), a slide rail (35), a lower slide seat (36), a slide rod frame (37), an upper slide seat (38), an electric telescopic rod (40), a T-shaped top plate (43), and a pull seat (45), wherein the side seat (34) is connected to both sides of the sampling frame (10), the slide rail (35) is connected to the lower inner wall of the sample chamber (2), the lower slide seat (36) is slidably connected to the slide rail (35), the slide rod frame (37) is connected to the lower slide seat (36), the upper slide seat (38) is slidably sleeved on the outer side of the slide rod frame (37), and the upper slide seat (38) and the slide rod frame (37) are connected to each other. ) are connected with a spring three (39) which is sleeved on the outside of the slide frame (37), the electric telescopic rod (40) is connected to both sides of the upper slide (38), the cleaning box (41) is connected to the upper output end of the two electric telescopic rods (40), the T-shaped top plate (43) is connected to the side of the cleaning box (41) away from the orifice plate frame (4), and cooperates with the rotating seat (12), the pulling seat (45) is slidably set in the sample chamber (2), and is rotatably connected with the lower sliding seat (36) by a rotating plate (44), and the upper end surface of the side seat (34) cooperates with the lower end surface of the pulling seat (45).

9. The liquid phase chip detection device according to claim 8, characterized in that: The upper end surface of the cleaning box (41) is provided with a plurality of cleaning holes (42) in an array. A cleaning agent nozzle, a brush and an emptying channel are installed in each cleaning hole (42). The electric control sampling tube (14) is slidably inserted in the cleaning hole (42).

10. The liquid phase chip detection device according to claim 8, characterized in that: Limiting slide bars (46) are installed on both sides of the upper inner wall of the sample chamber (2), the pull seat (45) is slidably sleeved on the outer side surface of the limiting slide bar (46), and a spring (47) is connected between the pull seat (45) and the upper inner wall of the sample chamber (2).

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