Cisatracurium besilate content testing method
The cisatracurium besylate solution is prepared by diluting the hydrochloric acid solution and measured using ultraviolet-visible spectrophotometry, which solves the problem of long time and high cost in testing the content of cisatracurium besylate in the prior art, and achieves a rapid and cost-effective method. Safe and accurate detection results.
CN103868868AInactive Publication Date: 2014-06-18SHANGHAI PHARMA DONGYING JIANGSU PHARMA CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI PHARMA DONGYING JIANGSU PHARMA CO LTD
- Filing Date
- 2014-03-26
- Publication Date
- 2014-06-18
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
The existing cisatracurium besylate content testing method takes a long time to prepare the mobile phase, is expensive, and uses organic solvents, causing environmental and human pollution.
Method used
The cisatracurium besylate solution is prepared by diluting it with hydrochloric acid solution, and the absorbance is measured at 280nm by UV-visible spectrophotometry, which simplifies the solution preparation process, reduces the harm to the environment and human body, and shortens the inspection time.
Benefits of technology
The inspection time and cost are significantly reduced. Each batch of products takes only 30 minutes on average, and the cost of the reagents used does not exceed 20 yuan, while ensuring the accuracy and safety of the inspection.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a cisatracurium besilate content testing method which comprises the following steps: respectively weighing a test substance and a reference substance in a measuring flask, adding hydrochloric acid for dissolving and metering a volume to a scale, shaking up to prepare a corresponding solution, finally, measuring the solution according to an ultraviolet-visible spectrophotometry, measuring absorbance at a place of a maximum adsorption wavelength of 280nm, and calculating the content of cisatracurium besilate according to an anhydrous substance. According to the cisatracurium besilate content testing method, the solution is simply and conveniently prepared, no organic solvent is used, and the pollution to the environment and the harm to a human body are small. The cisatracurium besilate content testing method is higher in testing speed, and the time of testing each batch of products in average only needs 30 min. A place of a maximum adsorption wavelength of 280 nm is selected, so that the testing accuracy is ensured. The cost of a reagent used in a process of checking each batch of samples does not exceed 20 yuan; the testing cost of each batch of samples by adopting a high-performance liquid chromatography method is not less than 200 yuan, so that the cost of enterprises is greatly lowered.
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