An H3N2 influenza mRNA vaccine targeting the tandem HA and NA proteins and its preparation method
CN120733020BActive Publication Date: 2026-05-26INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
- Filing Date
- 2025-07-16
- Publication Date
- 2026-05-26
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Abstract
This invention provides an H3N2 influenza mRNA vaccine targeting the tandem HA and NA proteins and its preparation method, relating to the field of vaccine preparation technology. The H3N2 influenza mRNA vaccine is obtained by linking the conserved amino acid sequences of HA and NA of H3N2 with GGGSGGGSGGGSGGGS, and the amino acid sequence of the H3N2 influenza mRNA vaccine is shown in SEQ ID NO.1, and the nucleic acid sequence is shown in SEQ ID NO.2. This invention overcomes the shortcomings of existing technologies, improves the protective effect of the vaccine against H3N2 influenza, and enables it to better cope with immune evasion from the latest emerging H3N2 variants.
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