Pharmaceutical intermediate synthesizer

Abstract

The invention discloses a medical intermediate synthesis device, and relates to the technical field of medical intermediate production, the medical intermediate synthesis device comprises a frame body assembly, the frame body assembly comprises a base, a mounting rack and an opening, the top surface of the base is fixedly connected with the mounting rack, two sides of the inner wall of the mounting rack are fixedly connected with a plurality of heating columns, and the top surface of the base is rotatably provided with a tank body assembly; the tank assembly comprises a synthesis tank body, a feeding pipe and a first gear ring, the synthesis tank body is located among the multiple heating columns, and a stirring assembly is arranged in the synthesis tank body. According to the invention, when raw materials are synthesized, the synthesis tank body rotates, a first rotating rod drives stirring blades to revolve reversely and rotate at the same time, so that the intermediate raw materials in the synthesis tank body form a spiral three-dimensional turbulent flow, the mixing uniformity is improved, and during stirring, a scraping plate scrapes the inner wall of the synthesis tank body at the same time, so that the raw material adhesion is reduced, and the mixing efficiency is improved. The thermal resistance caused by raw material adhesion is eliminated, the temperature imbalance of the local synthesis tank body is avoided, and the raw materials can be uniformly heated.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical intermediate production, in particular to a pharmaceutical intermediate synthesis device. Background Art

[0002] Pharmaceutical intermediate synthesis equipment is a specialized chemical equipment used to prepare pharmaceutical intermediates (i.e. key intermediates in the drug synthesis process). It realizes the transformation from basic raw materials to target intermediates by integrating reaction, mixing, heat transfer and other functions.

[0003] Existing pharmaceutical intermediate synthesis equipment usually uses a relatively simple stirring method when synthesizing raw materials, which reduces the uniformity of mixing. When the raw materials stick to the inner wall of the tank, it will lead to increased thermal resistance and cause temperature imbalance inside the tank, making it impossible to ensure uniform heating of the raw materials.

[0004] Therefore, it is necessary to propose a pharmaceutical intermediate synthesis device to solve the above problems. Summary of the Invention

[0005] The present invention aims to provide a pharmaceutical intermediate synthesis device to solve the problems that, during the synthesis of raw materials, the stirring method is relatively simple, which reduces the uniformity of mixing, and the raw materials adhere to the inner wall of the tank, which increases the thermal resistance and causes the temperature imbalance in the tank, making it impossible to ensure uniform heating of the raw materials.

[0006] To achieve the above object, the present invention provides the following technical solution: a pharmaceutical intermediate synthesis device, comprising a frame assembly, the frame assembly comprising a base, a mounting frame, and an opening, the mounting frame being fixedly connected to the top surface of the base, a plurality of heating columns being fixedly connected to both sides of the inner wall of the mounting frame, and a tank assembly being rotatably mounted on the top surface of the base;

[0007] The tank assembly includes a synthesis tank body, a feed pipe and a first gear ring. The synthesis tank body is located between a plurality of heating columns. A stirring assembly is provided inside the synthesis tank body. The stirring assembly includes a disc frame, two first rotating rods and a plurality of stirring blades.

[0008] A second rotating rod is rotatably connected to the middle of the inner wall of the synthesis tank body, the disc frame is fixedly connected to the top periphery of the second rotating rod, two first rotating rods are rotatably arranged on both sides of the disc frame, and the outer peripheries of the two first rotating rods are fixedly connected to a plurality of stirring blades, the stirring blades are inclined, and the ends of the stirring blades are bent upward;

[0009] A knocking assembly is provided on one side of the outer wall of the synthetic tank body, and the knocking assembly includes a rotating column, multiple elastic strips and multiple knocking balls. The rotating column is rotatably provided on one side of the outer wall of the tank body assembly, and the multiple elastic strips are fixedly connected to the outer periphery of the rotating column. The knocking balls are fixedly connected to the corresponding ends of the elastic strips, and the knocking balls are in active contact with the outer wall of the synthetic tank body.

[0010] Preferably, connecting rods are fixedly connected to both sides of the outer periphery of the disc rack and both sides of the bottom of the second rotating rod, and scrapers are fixedly connected to the two ends of the connecting rods on one side, and the scrapers are in active contact with the inner wall of the synthesis tank body.

[0011] Preferably, a second fixed plate is fixedly connected to one side of the base, and a first fixed plate is fixedly connected to the top of the mounting frame close to the second fixed plate. A limiting rod is fixedly connected between the first fixed plate and the second fixed plate, and the limiting rod is in movably contact with the elastic strip. The rotating column is rotatably arranged in the middle of the first fixed plate and the second fixed plate.

[0012] Preferably, a transmission assembly is provided on the top of the frame assembly, and the transmission assembly includes a motor, a first gear and two transmission wheels. The motor is fixedly connected to the top surface of the first fixed plate, the top of the rotating column passes through the first fixed plate and is fixedly connected to the motor shaft, the top of the rotating column and the top of the second rotating rod are both fixedly connected to the transmission wheels, and the two transmission wheels are both connected to the transmission belt.

[0013] Preferably, a second gear ring is fixedly connected to the top surface of the inner wall of the synthesis tank body, and the second gear ring is rotatably connected to the disc frame. Two second gears are provided inside the disc frame. The top end of the first rotating rod passes through the disc frame and is fixedly connected to the corresponding second gear, and the second gear is meshed with the second gear ring.

[0014] Preferably, the outer periphery of the top of the rotating column is fixedly connected to the first gear, the outer periphery of the top of the synthesis tank body is fixedly connected to the first gear ring, and the first gear is meshed with the first gear ring.

[0015] Preferably, a turntable is rotatably connected to the middle of the top surface of the frame assembly, a through hole is opened in the middle of the base and the turntable, and the turntable is fixedly connected to the bottom surface of the outer wall of the synthesis tank body.

[0016] Preferably, a discharge pipe is fixed and connected to the middle of the bottom surface of the synthesis tank body, and a feed pipe is fixed and connected to the top of the synthesis tank body, and the discharge pipe is located between the through holes.

[0017] Preferably, an opening is provided on the top of the mounting frame away from the first fixing plate.

[0018] Technical effects and advantages of the present invention:

[0019] 1. In the present invention, when the raw materials are synthesized, the synthesis tank body rotates, and the first rotating rod drives the stirring blade to rotate in the opposite direction, so that the intermediate raw materials in the synthesis tank body form a spiral three-dimensional turbulent flow, which improves the mixing uniformity. During stirring, the scraper also scrapes the inner wall of the synthesis tank body, reducing the sticking of raw materials and eliminating the thermal resistance caused by the sticking of raw materials, avoiding the temperature imbalance of the local synthesis tank body, and ensuring that the raw materials can be evenly heated.

[0020] 2. In the present invention, the arrangement of the inclined stirring blade and the upward bending of the end reduces shear damage to the intermediate raw materials during the stirring process, protects sensitive raw materials, and improves the purity of the intermediate raw materials synthesized. Moreover, when the stirring blade stirs, it pushes the intermediate raw materials to circulate up and down, reducing the time of the catalytic reaction and accelerating the synthesis of the intermediate raw materials.

[0021] 3. During the stirring process of the present invention, the synthesis tank body rotates, and the cooperation of the components enables the knocking ball to continuously knock on the periphery of the synthesis tank body. The vibration causes the raw materials attached to the inner wall of the synthesis tank body to fall off, further eliminating the thermal resistance of the raw material layer. At the same time, the knocking of the knocking ball can avoid the residue of raw materials and reduce the frequency of manual cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the structure of the present invention from the first perspective.

[0023] Figure 2 This is a schematic diagram of the structure of the present invention from a second viewing angle.

[0024] Figure 3 It is a cross-sectional schematic diagram of the present invention.

[0025] Figure 4 For the present invention Figure 3 Enlarged schematic diagram of point A in the middle.

[0026] Figure 5 For the present invention Figure 3 Enlarged schematic diagram of point B in the middle.

[0027] In the figure: 1, frame assembly; 11, base; 12, mounting frame; 13, opening; 14, first fixing plate; 15, second fixing plate; 16, through hole; 17, heating column; 18, turntable;

[0028] 2. Tank assembly; 21. Synthesis tank body; 22. Feed pipe; 23. First gear ring; 24. Discharge pipe;

[0029] 3. Stirring assembly; 31. Disc frame; 32. First rotating rod; 33. Stirring blade; 34. Connecting rod; 35. Scraper;

[0030] 4. striking assembly; 41. rotating column; 42. elastic strip; 43. striking ball; 44. limiting rod;

[0031] 5. Transmission assembly; 51. Motor; 52. First gear; 53. Transmission wheel; 54. Transmission belt; 55. Second rotating rod; 56. Second gear ring; 57. Second gear. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the drawings in the present invention. Obviously, the embodiments described are part of the embodiments of the present invention, not all of the embodiments, and they should not be understood as limitations on the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. In the description of the present invention, it should be understood that the terms used are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0033] The present invention provides Figures 1-5 The pharmaceutical intermediate synthesis device shown includes a frame assembly 1, which includes a base 11, a mounting frame 12 and an opening 13. The top surface of the base 11 is fixedly connected to the mounting frame 12, and multiple heating columns 17 are fixedly connected to the inner walls of the mounting frame 12 on both sides. The top surface of the base 11 is rotatably provided with a tank assembly 2; when using the device, the pharmaceutical intermediate raw materials are placed inside the synthesis tank body 21, and the tank body assembly 2 is rotated. The rotation of the tank body assembly 2 itself generates centrifugal force to ensure that the raw materials are better stirred. While stirring, the heating columns 17 are turned on, and the heating columns 17 heat the tank body assembly 2. In conjunction with the rotation of the synthesis tank body 21, the pharmaceutical intermediate raw materials are heated evenly, thereby improving the synthesis efficiency.

[0034] Furthermore, the tank assembly 2 includes a synthesis tank body 21, a feed pipe 22 and a first gear ring 23. The synthesis tank body 21 is located between multiple heating columns 17. A stirring assembly 3 is provided inside the synthesis tank body 21. The stirring assembly 3 includes a disc rack 31, two first rotating rods 32 and multiple stirring blades 33. When synthesizing pharmaceutical intermediates, the intermediate raw materials are stirred by the cooperation of the disc rack 31, the first rotating rod 32 and the stirring blades 33 to ensure faster synthesis of the raw materials.

[0035] It should be noted that a second rotating rod 55 is rotatably connected to the middle part of the inner wall of the synthesis tank body 21, the disc frame 31 is fixedly connected to the top periphery of the second rotating rod 55, and the two first rotating rods 32 are rotatably arranged on both sides of the disc frame 31. The outer peripheries of the two first rotating rods 32 are fixedly connected to multiple stirring blades 33, the stirring blades 33 are tilted, and the ends of the stirring blades 33 are bent upward; the rotation of the second rotating rod 55 drives the disc frame 31 to rotate, the rotation of the disc frame 31 drives the first rotating rod 32 to rotate, the rotation of the first rotating rod 32 drives the stirring blades 33 to rotate, and the first rotating rod 32 rotates while revolving along the disc frame 31 to stir the raw materials.

[0036] In the present invention, by setting the stirring blade 33 to be tilted and the end portion bent upward, the shear damage to the intermediate raw material is reduced during the stirring process, the sensitive raw materials are protected, and the purity of the synthesis of the intermediate raw material is improved. When the stirring blade 33 stirs, it pushes the intermediate raw material to circulate up and down, reducing the time of the catalytic reaction and accelerating the synthesis of the intermediate raw material.

[0037] It should also be noted that connecting rods 34 are fixedly connected to both sides of the outer periphery of the disc frame 31 and both sides of the bottom of the second rotating rod 55. The ends of the two connecting rods 34 on one side are fixedly connected to scrapers 35, and the scrapers 35 are in active contact with the inner wall of the synthesis tank body 21; the rotation of the second rotating rod 55 and the disc frame 31 drives the connecting rod 34 to rotate, and the rotation of the connecting rod 34 drives the scraper 35 to scrape the inner wall of the synthesis tank body 21, so that the inner wall of the synthesis tank body 21 will not stick to the raw materials.

[0038] In the present invention, when the raw materials are synthesized, the synthesis tank body 21 rotates by itself, and the first rotating rod 32 drives the stirring blade 33 to revolve in the opposite direction while rotating, so that the intermediate raw material in the synthesis tank body 21 forms a spiral three-dimensional turbulence, which improves the mixing uniformity. During stirring, the scraper 35 also scrapes the inner wall of the synthesis tank body 21, reducing the adhesion of the raw materials, eliminating the thermal resistance caused by the adhesion of the raw materials, avoiding the temperature imbalance of the local synthesis tank body 21, and ensuring that the raw materials can be evenly heated.

[0039] In the present invention, a knocking assembly 4 is provided on one side of the outer wall of the synthesis tank body 21, and the knocking assembly 4 includes a rotating column 41, multiple elastic strips 42 and multiple knocking balls 43. The rotating column 41 is rotatably provided on one side of the outer wall of the tank body assembly 2, and the multiple elastic strips 42 are fixedly connected to the outer periphery of the rotating column 41. The knocking balls 43 are fixedly connected to the corresponding ends of the elastic strips 42, and the knocking balls 43 are in active contact with the outer wall of the synthesis tank body 21; during the use of the device, the rotating column 41 rotates to drive the elastic strips 42 to rotate, and the elastic strips 42 rotate to drive the knocking balls 43 to rotate. After the knocking balls 43 rotate to the vicinity of the outer wall of the synthesis tank body 21, they knock on the synthesis tank body 21. The knocking can cause the raw materials stuck on the inner wall of the synthesis tank body 21 to fall off.

[0040] It should be noted that a second fixed plate 15 is fixedly connected to one side of the base 11, and a first fixed plate 14 is fixedly connected to the top of the mounting frame 12 near the second fixed plate 15. A limiting rod 44 is fixedly connected between the first fixed plate 14 and the second fixed plate 15. The limiting rod 44 is in movable contact with the elastic strip 42. The rotating column 41 is rotatably arranged in the middle of the first fixed plate 14 and the second fixed plate 15; the rotation of the rotating column 41 drives the elastic strip 42 to rotate, and the elastic strip 42 rotates and contacts with the limiting rod 44 and then bends. When the elastic strip 42 is away from the limiting rod 44, the elastic strip 42 uses elastic force to make the knocking ball 43 knock on the outer wall of the synthesis tank body 21.

[0041] During the stirring process of the present invention, the synthesis tank body 21 rotates, and the cooperation of the components enables the knocking ball 43 to continuously knock on the outer periphery of the synthesis tank body 21. The vibration causes the raw materials attached to the inner wall of the synthesis tank body 21 to fall off, further eliminating the thermal resistance of the raw material layer. At the same time, the knocking of the knocking ball 43 can avoid the residue of raw materials and reduce the frequency of manual cleaning.

[0042] In the present invention, a transmission assembly 5 is provided on the top of the frame assembly 1, and the transmission assembly 5 includes a motor 51, a first gear 52 and two transmission wheels 53. The motor 51 is fixedly connected to the top surface of the first fixed plate 14, and the top of the rotating column 41 passes through the first fixed plate 14 and is fixedly connected to the rotating shaft of the motor 51. The top of the rotating column 41 and the top of the second rotating rod 55 are both fixedly connected to the transmission wheel 53, and the two transmission wheels 53 are both connected to the transmission belt 54 for transmission. When the device needs to be used, the motor 51 is turned on, and the motor 51 drives the transmission wheel 53 on one side to rotate through the rotating column 41, and the transmission wheel 53 on one side drives the transmission wheel 53 on the other side to rotate through the transmission belt 54, and the rotation of the transmission wheel 53 on the other side drives the second rotating rod 55 to rotate.

[0043] It should be noted that a second gear ring 56 is fixedly connected to the top surface of the inner wall of the synthesis tank body 21, and the second gear ring 56 is rotatably connected to the disc frame 31. Two second gears 57 are arranged inside the disc frame 31. The top end of the first rotating rod 32 passes through the disc frame 31 and is fixedly connected to the corresponding second gear 57. The second gear 57 is meshed with the second gear ring 56; the second rotating rod 55 rotates to drive the disc frame 31 to rotate, and when the disc frame 31 rotates, it drives the first rotating rod 32 thereon to revolve orbitally, and the first rotating rod 32 drives the second gear 57 to rotate along the teeth of the second gear ring 56, so that the first rotating rod 32 revolves and rotates at the same time.

[0044] In the application, the top outer periphery of the rotating column 41 is fixedly connected with the first gear 52, the top outer periphery of the synthetic tank body 21 is fixedly connected with the first tooth ring 23, and the first gear 52 is meshingly connected with the first tooth ring 23; the rotating column 41 drives the first gear 52 to rotate at the same time, the first gear 52 drives the first tooth ring 23 to rotate, and the first gear 52 drives the synthetic tank body 21 to rotate.

[0045] It should be noted that the rotating disc 18 is rotatably connected to the top middle part of the frame assembly 1, the through holes 16 are formed in the middle part of the base 11 and the rotating disc 18, and the rotating disc 18 is fixedly connected to the bottom surface of the outer wall of the synthetic tank body 21; the synthetic tank body 21 drives the rotating disc 18 to rotate on the top surface of the base 11.

[0046] In the application, the bottom middle part of the synthetic tank body 21 is fixedly connected with and communicated with the discharge pipe 24, the top of the synthetic tank body 21 is fixedly connected with and communicated with the feeding pipe 22, and the discharge pipe 24 is located between the through holes 16; the raw materials of the pharmaceutical intermediates are added through the feeding pipe 22, the synthesized pharmaceutical intermediates are discharged through the discharge pipe 24, and the through holes 16 are arranged to enable the normal rotation of the tank body assembly 2.

[0047] It should be noted that the mounting frame 12 is provided with the opening 13 on the top side away from the first fixed plate 14; when it is needed to add raw materials into the synthetic tank body 21, the feeding pipe 22 is rotated to one side of the opening 13.

Claims

1. A pharmaceutical intermediate synthesis device, comprising a frame assembly (1), characterized in that: The frame assembly (1) comprises a base (11), a mounting frame (12) and an opening (13); the top surface of the base (11) is fixedly connected to the mounting frame (12); a plurality of heating columns (17) are fixedly connected to both sides of the inner wall of the mounting frame (12); and the top surface of the base (11) is rotatably provided with a tank assembly (2); The tank assembly (2) comprises a synthesis tank body (21), a feed pipe (22) and a first gear ring (23); the synthesis tank body (21) is located between a plurality of heating columns (17); a stirring assembly (3) is provided inside the synthesis tank body (21); the stirring assembly (3) comprises a disc frame (31), two first rotating rods (32) and a plurality of stirring blades (33); A second rotating rod (55) is rotatably connected to the middle of the inner wall of the synthesis tank body (21); the disc frame (31) is fixedly connected to the top periphery of the second rotating rod (55); two first rotating rods (32) are rotatably arranged on both sides of the disc frame (31); the peripheries of the two first rotating rods (32) are fixedly connected to a plurality of stirring blades (33); the stirring blades (33) are tilted, and the ends of the stirring blades (33) are bent upward; A knocking assembly (4) is provided on one side of the outer wall of the synthesis tank body (21). The knocking assembly (4) comprises a rotating column (41), a plurality of elastic strips (42) and a plurality of knocking balls (43). The rotating column (41) is rotatably provided on one side of the outer wall of the tank body assembly (2). The plurality of elastic strips (42) are fixedly connected to the outer periphery of the rotating column (41). The knocking balls (43) are fixedly connected to the ends of the corresponding elastic strips (42). The knocking balls (43) are in movable contact with the outer wall of the synthesis tank body (21).

2. A pharmaceutical intermediate synthesis device according to claim 1, characterized in that: Connecting rods (34) are fixedly connected to both sides of the outer periphery of the disc frame (31) and both sides of the bottom of the second rotating rod (55). The ends of the two connecting rods (34) on one side are fixedly connected to scrapers (35), and the scrapers (35) are in active contact with the inner wall of the synthesis tank body (21).

3. A pharmaceutical intermediate synthesis device according to claim 1, characterized in that: A second fixed plate (15) is fixedly connected to one side of the base (11); a first fixed plate (14) is fixedly connected to the top of one side of the mounting frame (12) close to the second fixed plate (15); a limiting rod (44) is fixedly connected between the first fixed plate (14) and the second fixed plate (15); the limiting rod (44) is in movable contact with the elastic strip (42); and the rotating column (41) is rotatably arranged in the middle of the first fixed plate (14) and the second fixed plate (15).

4. A pharmaceutical intermediate synthesis device according to claim 3, characterized in that: A transmission assembly (5) is provided on the top of the frame assembly (1), and the transmission assembly (5) includes a motor (51), a first gear (52) and two transmission wheels (53). The motor (51) is fixedly connected to the top surface of the first fixed plate (14). The top of the rotating column (41) passes through the first fixed plate (14) and is fixedly connected to the rotating shaft of the motor (51). The top of the rotating column (41) and the top of the second rotating rod (55) are both fixedly connected to the transmission wheel (53). The two transmission wheels (53) are both connected to the transmission belt (54) for transmission.

5. A pharmaceutical intermediate synthesis device according to claim 1, characterized in that: A second gear ring (56) is fixedly connected to the top surface of the inner wall of the synthesis tank body (21), and the second gear ring (56) is rotatably connected to the disc frame (31). Two second gears (57) are provided inside the disc frame (31). The top end of the first rotating rod (32) passes through the disc frame (31) and is fixedly connected to the corresponding second gear (57). The second gear (57) is meshed with the second gear ring (56).

6. A pharmaceutical intermediate synthesis device according to claim 4, characterized in that: The top periphery of the rotating column (41) is fixedly connected to the first gear (52), the top periphery of the synthesis tank body (21) is fixedly connected to the first gear ring (23), and the first gear (52) is meshedly connected to the first gear ring (23).

7. A pharmaceutical intermediate synthesis device according to claim 1, characterized in that: A turntable (18) is rotatably connected to the middle of the top surface of the frame assembly (1), a through hole (16) is provided in the middle of the base (11) and the turntable (18), and the turntable (18) is fixedly connected to the bottom surface of the outer wall of the synthesis tank body (21).

8. A pharmaceutical intermediate synthesis device according to claim 7, characterized in that: A discharge pipe (24) is fixed and connected to the middle of the bottom surface of the synthesis tank body (21), and a feed pipe (22) is fixed and connected to the top of the synthesis tank body (21). The discharge pipe (24) is located between the through holes (16).

9. A pharmaceutical intermediate synthesis device according to claim 1, characterized in that: An opening (13) is provided on the top of the mounting frame (12) on a side away from the first fixing plate (14).

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