Composition suitable for oil-in-water sunscreen system and application thereof

Abstract

The invention relates to a composition suitable for an oil-in-water sunscreen system and application of the composition. The composition is prepared from polysorbate, polyethylene glycol monomethyl ether polydimethylsiloxane, dextrin palmitate and hydrolyzed royal jelly protein. The composition is safe and non-irritant in formula, has excellent sunscreen performance, is easier to prepare a stable oil-in-water sunscreen product, does not need to be removed by a cleaning product, and can be washed by clean water.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a composition suitable for an oil-in-water sunscreen system and application thereof. BACKGROUND

[0002] UV rays can damage skin cells, causing sunburn, photoaging (wrinkles, pigmentation), and long-term exposure can increase the risk of skin cancer. Children's skin is thinner and more sensitive, and more susceptible to UV damage, and the damage accumulates, affecting the whole life. The physical sunscreen cream for children does not contain chemical sunscreen agents, reducing the risk of allergy and irritation; it is not easily absorbed by the skin, suitable for sensitive skin, and has high stability and is not easily decomposed; it takes effect immediately after application, without the need to wait, and is suitable for active children.

[0003] The oil-in-water physical sunscreen cream has a lighter and thinner texture, a refreshing skin feel, is easier to wash, reduces the risk of mildness during the removal process of the makeup removal product, and has high compatibility and is not easy to rub mud. However, in order to meet the requirements of the sun protection factor, a large amount of physical sunscreen powder is generally added, and in order to enhance the stability, a large amount of oil dispersant and emulsifier is often added, which can easily cause a heavy skin feel and difficulty in washing.

[0004] Therefore, it has become one of the technical problems to be solved to develop a composition suitable for an oil-in-water sunscreen system, which can improve the sunscreen effect while improving the refreshing degree of the skin feel and reducing the difficulty of washing. SUMMARY

[0005] In view of the deficiencies of the prior art, the present application aims to provide a composition suitable for an oil-in-water sunscreen system and application thereof. The composition has excellent sunscreen performance, and is easier to prepare a stable oil-in-water sunscreen product, and can be washed with clean water without the need for cleaning products to remove.

[0006] To achieve the purpose of the present application, the following technical solutions are adopted:

[0007] In a first aspect, the present application provides a composition suitable for an oil-in-water sunscreen system, which comprises polysorbate, polyethylene glycol methyl ether dimethicone, dextrin palmitate and hydrolyzed royal jelly protein.

[0008] Polysorbate has good hydrophilicity and lipophilicity balance, can enhance the solubility of the system in water, and is convenient to clean after use. Polyethylene glycol methyl ether dimethicone has the hydrophobicity of silicone oil and the hydrophilicity of polyethylene glycol, can improve the skin feel of sunscreen products, and makes the products more easily washed off under clean water, and synergizes with polysorbate to further improve the washability of the system. The present application creatively finds that the water-washable effect of polysorbate and polyethylene glycol methyl ether dimethicone is better than that of single polysorbate or single polyethylene glycol methyl ether dimethicone, indicating that the two have significant synergistic effect in improving the water-washable performance of sunscreen products.

[0009] Dextrin palmitate is a fatty acid ester extracted from palm oil, which can form a network gel structure and play a role in thickening oil, and can improve the adhesion of sunscreen on the skin surface; hydrolyzed royal jelly protein is a small molecular peptide or amino acid mixture obtained by hydrolysis process (such as enzymatic hydrolysis) of royal jelly, which retains the active ingredients in royal jelly, has small molecular weight, good water solubility and skin permeability. The present application creatively finds that the sunscreen effect of sunscreen products using dextrin palmitate and hydrolyzed royal jelly protein is significantly better than that of single dextrin palmitate or single hydrolyzed royal jelly protein, indicating that the two have significant synergistic effect in sunscreen synergism.

[0010] Preferably, in the polysorbate, the sorbitol esterified fatty acid is selected from dodecanoic acid, hexadecanoic acid, octadecanoic acid or octadecenoic acid.

[0011] Preferably, the polysorbate is polysorbate-60.

[0012] Preferably, the number of repeating units of polyethylene glycol in the polyethylene glycol methyl ether dimethicone is 8-15, for example, it can be 8, 10, 11, 15, etc.

[0013] Preferably, the polyethylene glycol methyl ether dimethicone is PEG-11 methyl ether dimethicone.

[0014] Preferably, the composition comprises 0.3-0.8 parts of polysorbate, 0.05-0.3 parts of polyethylene glycol methyl ether dimethicone, 0.1-0.5 parts of dextrin palmitate and 0.05-0.3 parts of hydrolyzed royal jelly protein by mass fraction.

[0015] The specific point value in 0.3-0.8 parts can be selected as 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, etc., the specific point value in 0.05-0.3 parts can be selected as 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, etc., the specific point value in 0.1-0.5 parts can be selected as 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc., the specific point value in 0.05-0.3 parts can be selected as 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, etc., and the specific point value in 0.1-0.8 parts can be selected as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, etc.

[0016] Preferably, the composition further comprises glyceryl behenate.

[0017] Glyceryl behenate is an ester compound generated by esterification reaction of behenic acid and glycerol, which contains both the hydrophilic segment of glycerol structure and the hydrophobic structure of long carbon chain of behenic acid. It is found that the use of glyceryl behenate and polyethylene glycol methyl ether dimethicone has a significant synergistic effect in improving the refreshing feeling of sunscreen products.

[0018] Preferably, the composition comprises polysorbate 0.3-0.8 parts, polyethylene glycol methyl ether dimethicone 0.05-0.3 parts, dextrin palmitate 0.1-0.5 parts, hydrolyzed royal jelly protein 0.05-0.3 parts, and glyceryl behenate 0.1-0.8 parts in terms of mass fraction.

[0019] The specific point value in 0.3-0.8 parts can be selected as 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, etc., the specific point value in 0.05-0.3 parts can be selected as 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, etc., the specific point value in 0.1-0.5 parts can be selected as 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, etc., 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc., the specific point value in 0.05-0.3 parts can be selected as 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, etc., and the specific point value in 0.1-0.8 parts can be selected as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, etc.

[0020] Preferably, the hydrolyzed royal jelly protein is prepared by a preparation method comprising the following steps:

[0021] (1) Mix the royal jelly with water, and perform microwave treatment, filter the filtrate after the microwave treatment to obtain a pretreatment liquid.

[0022] (2) Mix the pretreatment liquid with a compound enzyme to perform enzymolysis reaction to obtain an enzymolysis liquid, filter the filtrate of the enzymolysis liquid to obtain the hydrolyzed royal jelly protein.

[0023] The compound enzyme in step (2) comprises papain, trypsin and neutral protease.

[0024] In the preparation process of the hydrolyzed royal jelly protein, the royal jelly is first subjected to microwave treatment, and then the pretreatment liquid obtained after the microwave treatment is subjected to enzymolysis reaction, so that the royal jelly raw material can be better hydrolyzed, and the mixture of small molecule peptides obtained has more excellent sunscreen synergistic effect.

[0025] The pretreatment liquid is subjected to enzymolysis by using the compound enzyme, wherein the papain is a cysteine protease, can hydrolyze various protein substrates, has relatively wide specificity for peptide bonds, and tends to hydrolyze peptide bonds containing aromatic amino acids such as phenylalanine, tyrosine and tryptophan, or hydrophobic amino acids such as leucine and valine; the trypsin is a serine protease, can hydrolyze peptide bonds at the carboxyl end of basic amino acids such as lysine and arginine in proteins; and the neutral protease has high catalytic efficiency and wide substrate adaptability. It is found creatively that the pretreatment liquid of the royal jelly is subjected to enzymolysis treatment by using the papain, the trypsin and the neutral protease in combination, the enzymolysis product not only retains the active ingredients of the royal jelly protein, but also can be better compatible with physical sunscreen agents such as titanium dioxide, and the sunscreen enhancing effect of the prepared hydrolyzed royal jelly protein is further improved.

[0026] Preferably, the ratio of the royal jelly to water in step (1) is 1:5-1:20 g / mL, for example, 1:5 g / mL, 1:10 g / mL, 1:15 g / mL or 1:20 g / mL.

[0027] Preferably, the temperature of the microwave treatment in step (1) is 50-80℃, the power of the microwave treatment is 200-500 W, and the time of the microwave treatment is 10-30 min.

[0028] Specific point values in 50-80℃ can be selected as 50℃, 60℃, 70℃ or 80℃, specific point values in 200-500 W can be selected as 200 W, 250 W, 300 W, 350 W, 400 W, 450 W or 500 W, and specific point values in 10-30 min can be selected as 10 min, 15 min, 20 min, 25 min or 30 min.

[0029] Preferably, the mass ratio of the pretreatment liquid to the complex enzyme in step (2) is 100:1-100:5, the temperature of the enzymatic reaction is 30-50℃, and the time of the enzymatic reaction is 0.5-2 h.

[0030] Specific point values in 100:1-100:5 can be selected as 100:1, 100:2, 100:3, 100:4, 100:5, etc., specific point values in 30-50℃ can be selected as 30℃, 35℃, 40℃, 45℃, 50℃, etc., and specific point values in 0.5-2 h can be selected as 0.5 h, 1 h, 1.5 h, 2 h, etc.

[0031] Preferably, the mass ratio of the papain, trypsin and neutral protease in step (2) is (1-3):(0.5-1):(0.1-0.5).

[0032] Specific point values in 1-3 can be selected as 1, 1.5, 2, 2.5, 3, etc., specific point values in 0.5-1 can be selected as 0.5, 0.6, 0.7, 0.8, 0.9, 1, etc., and specific point values in 0.1-0.5 can be selected as 0.1, 0.2, 0.3, 0.4, 0.5, etc.

[0033] In the second aspect, the present application provides an oil-in-water sunscreen cream, which comprises the composition of the first aspect, a physical sunscreen agent, a stabilizer, an emulsifier, a thickening agent, an antioxidant, water, an optional moisturizer and an optional dispersant.

[0034] Preferably, the physical sunscreen agent comprises titanium dioxide modified by a surface treatment agent.

[0035] Preferably, the surface treatment agent comprises any one or a combination of at least two of silica, aluminum hydroxide or triethoxyl octyl silane.

[0036] Preferably, the stabilizer comprises octyl trimethyl siloxane and isononyl isononanoate.

[0037] Octyl trimethyl siloxane has the characteristics of low surface tension, good lubricity, strong hydrophobicity, etc., has good compatibility with the surface of titanium dioxide, can be adsorbed on the surface of particles to reduce the mutual attraction between particles and prevent agglomeration; isononyl isononanoate is a branched fatty acid ester generated by esterification reaction of isononyl alcohol and isononanoic acid, has strong solubility, excellent dispersing power for powder, and excellent compatibility with other raw materials in sunscreen cream. The present application creatively finds that octyl trimethyl siloxane and isononyl isononanoate have significant synergistic effect in improving the stability of the oil-in-water sunscreen cream involved in the present application.

[0038] Preferably, the mass ratio of the octylpolymethylsiloxane and isononyl isononanoate is 1:1-1:4, for example, it can be 1:1, 1:1.5, 1:2, 1:2.5, 1:3.5, 1:4.5, 1:4, etc.

[0039] Preferably, the emulsifier comprises a cocoglycoside-coceth complex and / or cetylstearyl alcohol.

[0040] Preferably, the thickening agent comprises polyacrylamide, laureth, C13-14 isoparaffin, water complex and / or xanthan gum.

[0041] Preferably, the antioxidant comprises para-hydroxyacetophenone.

[0042] Preferably, the humectant comprises any one or a combination of at least two of glycerin, 1,3-propanediol, 1,2-hexanediol.

[0043] Preferably, the dispersing agent comprises polyhydroxystearic acid.

[0044] Preferably, the oil-in-water sunscreen cream comprises 0.5-2.5 parts of the composition of the first aspect, 5-10 parts of a physical sunscreen agent, 5-10 parts of a stabilizing agent, 2-4 parts of an emulsifier, 0.3-2 parts of a thickening agent, 0.2-0.8 parts of an antioxidant, 5-10 parts of a humectant, and 60-85 parts of water, in terms of mass fraction.

[0045] Preferably, the specific point values in 0.5-2.5 parts can be selected as 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, etc., the specific point values in 5-10 parts can be selected as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc., the specific point values in 2-4 parts can be selected as 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, etc., the specific point values in 0.3-2 parts can be selected as 0.3 parts, 0.6 parts, 0.9 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc., the specific point values in 0.2-0.8 parts can be selected as 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, etc., the specific point values in 0.2-0.4 parts can be selected as 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, etc., and the specific point values in 60-85 parts can be selected as 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, etc.

[0046] The oil-in-water sunscreen cream according to the present application does not need to add a large amount of a physical sunscreen agent, and by adding the composition suitable for an oil-in-water sunscreen system according to the first aspect, an excellent sunscreen effect can be achieved; at the same time, the sunscreen cream also does not need to add a large amount of a surfactant, and by adding a small amount of a stabilizing agent, the stability of the product is greatly improved, and at the same time, the skin does not feel heavy, and it is easy to clean.

[0047] The numerical range described in the present application includes not only the point values listed above, but also any point values between the above numerical ranges that are not listed, and the present application does not exhaustively list the specific point values included in the range for the sake of brevity and simplicity.

[0048] Compared with the prior art, the present application has the following beneficial effects:

[0049] The composition suitable for the oil-in-water sunscreen system has excellent sunscreen performance, and is easier to prepare a stable oil-in-water sunscreen product, without the need for cleaning product removal, and can be washed with water.

[0050] Further, glyceryl behenate is added to the composition, which has a significant synergistic effect with polyethylene glycol methyl ether dimethicone in improving the refreshing degree of the sunscreen product.

[0051] Further, in the preparation process of hydrolyzed royal jelly protein, the present application can better hydrolyze royal jelly by first microwave treating the royal jelly and then performing enzymatic reaction on the pretreated liquid obtained after microwave treatment, and the mixture of small molecule peptides obtained has more excellent sunscreen enhancing effect. In addition, controlling the microwave treatment power at 200-500W, or setting the complex as a combination of papain, trypsin and neutral protease, can further improve the sunscreen enhancing effect of hydrolyzed royal jelly protein.

[0052] Further, the composition of the oil-in-water sunscreen system of the present application can be added to the oil-in-water sunscreen cream, and only a small amount of sunscreen agent is needed to make the sunscreen product have excellent sunscreen performance; at the same time, in the oil-in-water sunscreen cream, the addition of the stabilizer composed of octyl trimethylsiloxane and isononyl isononanoate can further improve the powder stability and heat and cold resistance of the sunscreen product. DETAILED DESCRIPTION

[0053] In order to further illustrate the technical means adopted by the present application and its effects, the technical solutions of the present application will be further described below in combination with the preferred embodiments of the present application, but the present application is not limited in the scope of the embodiments.

[0054] The sources of each component / ingredient in the following embodiments are shown in Table 1.

[0055] Table 1

[0056]

[0057] Preparation Example 1

[0058] The present preparation example provides a hydrolyzed royal jelly protein, which is prepared by the following method:

[0059] (1) Mix the royal jelly with water according to a material-liquid ratio of 1:10 g / mL, and perform microwave treatment (the microwave treatment temperature is 70°C, the power is 300 W, and the time is 20 min); filter the microwave treatment product to collect the filtrate, and obtain a pretreatment liquid;

[0060] (2) Add a composite enzyme (the composite enzyme is papain, trypsin, and neutral protease with a mass ratio of 2:0.8:0.3) with a mass of 3% of the pretreatment liquid to the pretreatment liquid, and perform an enzymolysis reaction (the enzymolysis reaction temperature is 40°C, and the time is 1 h) to obtain an enzymolysis liquid; filter the enzymolysis liquid to take the filtrate, concentrate the filtrate to 20% (v / v), freeze-dry the concentrated liquid, and obtain a royal jelly protein hydrolysate.

[0061] Preparation Example 2

[0062] The present preparation example provides a royal jelly protein hydrolysate, which is prepared by the following method:

[0063] (1) Mix the royal jelly with water according to a material-liquid ratio of 1:5 g / mL, and perform microwave treatment (the microwave treatment temperature is 50°C, the power is 200 W, and the time is 30 min); filter the microwave treatment product to collect the filtrate, and obtain a pretreatment liquid;

[0064] (2) Add a composite enzyme (the composite enzyme is papain, trypsin, and neutral protease with a mass ratio of 1:1:0.1) with a mass of 5% of the pretreatment liquid to the pretreatment liquid, and perform an enzymolysis reaction (the enzymolysis reaction temperature is 30°C, and the time is 2 h) to obtain an enzymolysis liquid; filter the enzymolysis liquid to take the filtrate, concentrate the filtrate to 20% (v / v), freeze-dry the concentrated liquid, and obtain a royal jelly protein hydrolysate.

[0065] Preparation Example 3

[0066] The present preparation example provides a royal jelly protein hydrolysate, which is prepared by the following method:

[0067] (1) Mix the royal jelly with water according to a material-liquid ratio of 1:20 g / mL, and perform microwave treatment (the microwave treatment temperature is 80°C, the power is 500 W, and the time is 10 min); filter the microwave treatment product to collect the filtrate, and obtain a pretreatment liquid;

[0068] (2) Add a composite enzyme (the composite enzyme is papain, trypsin, and neutral protease with a mass ratio of 3:0.5:0.5) with a mass of 1% of the pretreatment liquid to the pretreatment liquid, and perform an enzymolysis reaction (the enzymolysis reaction temperature is 50°C, and the time is 0.5 h) to obtain an enzymolysis liquid; filter the enzymolysis liquid to take the filtrate, concentrate the filtrate to 20% (v / v), freeze-dry the concentrated liquid, and obtain a royal jelly protein hydrolysate.

[0069] Preparation Example 4

[0070] The present preparation example provides a hydrolyzed royal jelly protein, which is only different from the preparation example 1 in that the power of microwave treatment in step (1) is adjusted to 600 W, and the remaining steps are consistent with the preparation example 1.

[0071] Preparation example 5

[0072] The present preparation example provides a hydrolyzed royal jelly protein, which is only different from the preparation example 1 in that the power of microwave treatment in step (1) is adjusted to 150 W, and the remaining steps are consistent with the preparation example 1.

[0073] Preparation example 6

[0074] The present preparation example provides a hydrolyzed royal jelly protein, which is only different from the preparation example 1 in that the total mass of the complex enzyme is kept unchanged in step (2), and the complex enzyme is adjusted to papain and trypsin with a mass ratio of 2:0.8, and the remaining steps are consistent with the preparation example 1.

[0075] Preparation example 7

[0076] The present preparation example provides a hydrolyzed royal jelly protein, which is only different from the preparation example 1 in that the total mass of the complex enzyme is kept unchanged in step (2), and the complex enzyme is adjusted to papain and trypsin with a mass ratio of 2:0.3, and the remaining steps are consistent with the preparation example 1.

[0077] Preparation example 8

[0078] The present preparation example provides a hydrolyzed royal jelly protein, which is only different from the preparation example 1 in that the total mass of the complex enzyme is kept unchanged in step (2), and the complex enzyme is adjusted to papain and trypsin with a mass ratio of 2:0.8, and the remaining steps are consistent with the preparation example 1.

[0079] Example 1

[0080] The present example provides a composition, which comprises, in mass parts:

[0081] Polysorbate-60 0.5 parts, PEG-11 methyl ether dimethicone 0.1 part, dextrin palmitate 0.2 part, hydrolyzed royal jelly protein obtained by the preparation example 1 0.1 part, glyceryl behenate 0.2 part.

[0082] Example 2

[0083] The present example provides a composition, which comprises, in mass parts:

[0084] Polysorbate-60 0.3 parts, PEG-11 methyl ether dimethicone 0.3 parts, dextrin palmitate 0.1 part, hydrolyzed royal jelly protein obtained by the preparation example 2 0.2 part, glyceryl behenate 0.1 part.

[0085] Example 3

[0086] This embodiment provides a composition comprising, by weight:

[0087] 0.8 parts of polysorbate 60, 0.05 parts of PEG-11 methyl ether polydimethylsiloxane, 0.3 parts of dextrin palmitate, 0.05 parts of hydrolyzed royal jelly protein obtained in Preparation Example 3, and 0.3 parts of glyceryl behenate.

[0088] Example 4-Example 8

[0089] Examples 4 to 8 each provide a composition, the difference between which is different from Example 1 is that the hydrolyzed royal jelly protein obtained in Preparation Example 1 is replaced by the hydrolyzed royal jelly protein obtained in Preparation Example 4 to Preparation Example 8, respectively, and the components and addition amounts of the other raw materials remain consistent with those in Example 1.

[0090] Example 9

[0091] This embodiment provides a composition, which differs from Example 1 only in that glyceryl behenate is not included in the composition, and the reduced mass fraction is supplemented by PEG-11 methyl ether polydimethylsiloxane. The components and addition amounts of the remaining raw materials are consistent with those in Example 1.

[0092] Comparative Example 1

[0093] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include polysorbate 60, and the reduced mass fraction is supplemented by PEG-11 methyl ether polydimethylsiloxane. The components and addition amounts of the remaining raw materials are consistent with those in Example 1.

[0094] Comparative Example 2

[0095] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include PEG-11 methyl ether polydimethylsiloxane, and the reduced mass fraction is supplemented by polysorbate 60. The components and addition amounts of the remaining raw materials are consistent with those in Example 1.

[0096] Comparative Example 3

[0097] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include dextrin palmitate, and the reduced mass fraction is supplemented by hydrolyzed royal jelly protein. The components and addition amounts of the remaining raw materials are consistent with those in Example 1.

[0098] Comparative Example 4

[0099] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include hydrolyzed royal jelly protein, and the reduced mass fraction is supplemented by dextrin palmitate, and the components and addition amounts of the remaining raw materials are consistent with those in Example 1.

[0100] Comparative Example 5

[0101] This comparative example provides a composition, which differs from Example 1 only in that PEG-11 methyl ether polydimethylsiloxane is not included in the composition, and the reduced mass fraction is supplemented by glyceryl behenate. The components and addition amounts of the remaining raw materials are consistent with those in Example 1.

[0102] Application Example 1

[0103] This application example provides an oil-in-water sunscreen, including the components shown in Table 2.

[0104] Table 2

[0105]

[0106] The preparation method is as follows:

[0107] (1) Dissolve and mix all the components in phase A at 80°C and disperse them evenly; dissolve and mix all the components in phase B at 80°C and disperse them evenly; dissolve and mix all the components in phase C at 60°C and cool to 25°C for later use.

[0108] (3) Add phase A to phase B while stirring, then homogenize at 2500 rpm for 5 min, stirring and cooling to 40°C, and add phase C to the mixture of phases A and B, stirring evenly and cooling to 25°C.

[0109] Application Example 2

[0110] This application example provides an oil-in-water sunscreen, including the components shown in Table 3.

[0111] Table 3

[0112]

[0113] The preparation method is as follows:

[0114] (1) Dissolve and mix all components in phase A at 85°C and disperse them evenly; dissolve and mix all components in phase B at 85°C; dissolve and mix all components in phase C at 65°C and cool to 25°C for later use.

[0115] (3) Add phase A to phase B while stirring, then homogenize at 2000 rpm for 10 min, stirring and cooling to 35°C, and add phase C to the mixture of phases A and B, stirring evenly and cooling to 25°C.

[0116] Application Example 3

[0117] This application example provides an oil-in-water sunscreen cream comprising the components shown in Table 4.

[0118] Table 4

[0119]

[0120] The preparation method is as follows:

[0121] (1) Dissolve and mix the components in phase A at 75°C, homogenize and uniformly disperse; dissolve and mix the components in phase B uniformly at 75°C; dissolve and mix the components in phase C uniformly at 55°C, and then reduce to 25°C for standby.

[0122] (3) Under stirring, pour phase A into phase B, then homogenize at a speed of 3000 rpm for 5 min, reduce the temperature to 35°C under stirring, pour phase C into the mixture of phases A and B, stir uniformly and reduce to 25°C.

[0123] Application Examples 4-9

[0124] Application Examples 4-9 each provide an oil-in-water sunscreen cream, which differs from Application Example 1 only in that the composition of Example 1 in phase A is replaced by an equal amount of the composition of Example 4-9, respectively, and the rest of the formulation and preparation method remain the same as in Application Example 1.

[0125] Application Example 10

[0126] This application example provides an oil-in-water sunscreen cream, which differs from Application Example 1 only in that the total mass of the stabilizer is kept unchanged, and the stabilizer is adjusted to 8 parts of octyl trimethylsiloxane, and the rest of the formulation and preparation method remain the same as in Application Example 1.

[0127] Application Example 11

[0128] This application example provides an oil-in-water sunscreen cream, which differs from Application Example 1 only in that the total mass of the stabilizer is kept unchanged, and the stabilizer is adjusted to 8 parts of isononyl isononanoate, and the rest of the formulation and preparation method remain the same as in Application Example 1.

[0129] Comparative Application Examples 1-5

[0130] Comparative Application Examples 1-5 each provide an oil-in-water sunscreen cream, which differs from Application Example 1 only in that the composition of Example 1 in phase A is replaced by an equal amount of the composition of Comparative Example 1-5, respectively, and the rest of the formulation and preparation method remain the same as in Application Example 1.

[0131] Comparative Application Example 6

[0132] The application example provides an oil-in-water sunscreen cream, which is only different from the application example 1 in that no stabilizer is added in the formula, the reduced mass fraction is supplemented to 100 parts by water, and the rest of the formula and the preparation method are consistent with the application example 1.

[0133] Comparative application example 7

[0134] The application example provides an oil-in-water sunscreen cream, which is only different from the application example 1 in that no stabilizer is added in the formula, the reduced mass fraction is supplemented to 100 parts by water, and the rest of the formula and the preparation method are consistent with the application example 1.

[0135] Test example 1

[0136] The sunscreen index (SPF value) of the oil-in-water sunscreen cream in each application example and comparative application example is tested in the test example.

[0137] (1) Test method:

[0138] 60 healthy volunteers aged 18-60 years old are selected and evenly divided into 6 groups, 10 people in each group, and each person tests 3 samples to be tested (the samples to be tested are the oil-in-water sunscreen creams in each application example and comparative application example), and each group of volunteers tests the same 3 samples to be tested. A radiation area is selected on the back skin of the subject, and the minimum irradiation dose at which the skin appears red is the minimum erythema dose MED of the normal skin of the subject. The test product is applied to the skin of the subject, and the sample is weighed at a dosage of 2.00±0.05 mg / cm 2 , and the sample is evenly applied to the test area. After waiting for 15-30 min, the minimum irradiation dose at which the skin appears red is the MED of the skin of the subject under the protection of the product. The SPF value of the sample for a single subject is calculated by the following formula:

[0139] Individual SPF = MED of the skin protected by the sample / MED of the skin without protection.

[0140] (2) Test results:

[0141] The SPF values of the oil-in-water sunscreen creams in each application example and comparative application example are shown in Table 5. It can be seen that the composition suitable for the oil-in-water sunscreen system can significantly improve the SPF value of the sunscreen cream.

[0142] From the data of the application example 1 and the comparative application examples 3-4, it can be seen that the dextrin palmitate and the hydrolyzed royal jelly protein have a significant synergistic effect on sunscreen enhancement.

[0143] It can be seen from the comparison of the data of application example 1 and application examples 4-8 that, in the preparation process of the royal jelly protein hydrolysate, controlling the microwave treatment power at 200-500 W can further improve the sunscreen enhancing effect of the royal jelly protein; in addition, in the preparation process of the royal jelly protein hydrolysate, using papain, trypsin and neutral protease as a composite enzyme to enzymatically hydrolyze the pretreated liquid after microwave treatment can further improve the content of the effective component in the product, so that the royal jelly protein hydrolysate can better play a synergistic effect with the dextrin palmitate.

[0144] Test example 2

[0145] The water washability of the oil-in-water sunscreen cream of each application example and the comparative application example is tested in this test example.

[0146] (1) Test method:

[0147] 90 healthy volunteers aged 18-60 years old are selected and evenly divided into 18 groups, 5 people in each group, and each group uses the oil-in-water sunscreen cream of each application example and the comparative application example, and the water washability test is performed according to the test method in the group standard of the water washability test evaluation method for sunscreen cosmetics.

[0148] (1.1) T0 stage: the subjects clean their faces with cleaning products, and after sitting for 30 min in an independent environment with a temperature of 21±1℃ and a relative humidity of 50±10%, the skin colorimeter and facial image analyzer are used to measure the index base value of the test site of the subjects; the volunteers in each group use the sunscreen cream products of each application example and the comparative application example under the guidance.

[0149] (1.2) T1 stage: after using the sunscreen cream product for 30 min, the skin colorimeter and facial image analyzer are used to measure the index of the test site of the subjects; the volunteers in each group clean their faces under the guidance (half of the face is cleaned with a water cleansing towel, and the other half of the face is cleaned with a water cleansing towel after using makeup remover).

[0150] (1.3) T2 stage: after cleaning the face for 30 min, the skin colorimeter and facial image analyzer are used to measure the index of the test site of the subjects.

[0151] (2) Test results:

[0152] The cleaning rate is calculated according to the method in the water washability test evaluation method for sunscreen cosmetics, and the test results of the cleaning rate of each sunscreen product are shown in Table 5, and the water washability is considered when the cleaning rate is >75%, and the water washability is considered when the cleaning rate is ≥90.

[0153] It can be seen from the data in Table 5 that the composition suitable for the oil-in-water sunscreen system according to the present application can significantly improve the water washability of the sunscreen cream.

[0154] In addition, it can be seen from the data of application example 1 and comparative application example 1-2 that polysorbate and polyethylene glycol methyl ether dimethicone have a significant synergistic effect on water washability.

[0155] Test example 3

[0156] The present test example tests the refreshing degree of the oil-in-water sunscreen cream of each of the above application examples and comparative application examples.

[0157] (1) Test method: 90 subjects in test example 2 were selected and divided into 18 groups, 5 people in each group. After sitting for 30 min in the same temperature of 21±1℃ and relative humidity of 50±10% in an independent environment, the oil-in-water sunscreen cream of each of the above application examples and comparative application examples was used, and the subjects rated the refreshing degree of the sunscreen cream. The score is an integer in 1-10, and the average value of each sample is taken after the scoring is completed. The higher the score, the stronger the refreshing feeling.

[0158] (2) Test results:

[0159] The test results are shown in Table 5, and the results show that the water washable composition suitable for the oil-in-water sunscreen system involved in the present application can significantly improve the use refreshing degree of the sunscreen cream.

[0160] At the same time, it can be seen from the data of application example 1 and application example 9, comparative application example 5 that glyceryl behenate and polyethylene glycol methyl ether dimethicone have a significant synergistic effect on improving the use refreshing degree of sunscreen products.

[0161] Table 5

[0162]

[0163] Test example 4

[0164] The present test example tests the safety of the oil-in-water sunscreen cream of each of the above application examples and comparative application examples.

[0165] (1) Test method:

[0166] 60 subjects in test example 1 were selected and divided into 6 groups, 10 people in each group. Each person tested 3 test samples (the test samples were the oil-in-water sunscreen cream of each of the above application examples and comparative application examples), and each group of volunteers tested the same 3 test samples.

[0167] After the back of the subject is cleaned, the patch tester with the same quality of sunscreen cream sample is attached to the selected position on the back with a non-irritating adhesive tape. After the patch is attached, it is pressed evenly on the skin with fingers for 48 h. The subject keeps the patch area dry within 48 h, avoids vigorous exercise, scratches the patch area, and long-term sunlight exposure, etc. After 48 h, the tester is removed and marked. After 30 min, when the pressure marks disappear, the determination is made under sufficient light.

[0168] The skin adverse reaction grading standard is shown in Table 6.

[0169] Table 6

[0170]

[0171] (2) Test results:

[0172] The safety test results of the oil-in-water sunscreen cream of each application example and the comparative application example are shown in Table 7, and the results show that the sunscreen cream involved in the present application is safe and non-irritating.

[0173] Table 7

[0174]

[0175] Test Example 5

[0176] The stability of the oil-in-water sunscreen cream of each application example and the comparative application example is tested in this test example.

[0177] (1) Test method:

[0178] (1.1) Appearance stability: The oil-in-water sunscreen cream of each application example and the comparative application example is placed under room temperature standard light source, and the appearance state of the material is observed.

[0179] (1.2) Heat resistance: The oil-in-water sunscreen cream of each application example and the comparative application example is placed in a 45℃ electric constant temperature incubator for 30 days, and the appearance state of the material is observed after recovery to room temperature.

[0180] (1.3) Cold resistance: The oil-in-water sunscreen cream of each application example and the comparative application example is placed in a-10℃ refrigerator for 30 days, and the appearance state of the material is observed after recovery to room temperature.

[0181] (1.4) Cycle heat stability: Within 72 h, the oil-in-water sunscreen cream of each application example and the comparative application example is repeatedly changed between 10℃ and 45℃, and such repeated operation is performed for 3 cycles. The appearance state of the material is observed after recovery to room temperature.

[0182] (2) Test results:

[0183] The stability test results of the oil-in-water sunscreen cream of each application example and the comparative application example are shown in Table 8, and it can be seen that the oil-in-water sunscreen cream related to the present application has excellent storage stability and less restriction on the storage environment.

[0184] In addition, as can be seen from the comparison of the data of application example 1 and application examples 10-11 and comparative application example 6, octylpolymethylsiloxane and isononyl isononanoate have significant synergistic effect in improving the stability of the composition, and the addition of the stabilizer can improve the stability of the sunscreen product, thereby exerting excellent effects in the aspects of refreshing, washable, sunscreen enhancement, etc.

[0185] Table 8

[0186]

[0187] The applicant declares that the technical solutions of the present application are illustrated by the above-mentioned embodiments, but the present application is not limited to the above-mentioned embodiments, that is, it does not mean that the present application must rely on the above-mentioned embodiments to be implemented. It should be understood by those skilled in the art that any improvement of the present application, equivalent replacement of each raw material of the product of the present application, addition of auxiliary ingredients, selection of specific modes, etc. fall within the protection scope and disclosure scope of the present application.

[0188] The preferred embodiments of the present application are described in detail above, but the present application is not limited to the specific details in the above-mentioned embodiments, and within the technical concept scope of the present application, the technical solutions of the present application can be subjected to various simple modifications, and these simple modifications all belong to the protection scope of the present application.

[0189] In addition, it should be noted that each specific technical feature described in the above-mentioned specific embodiments can be combined by any suitable method without contradiction, and in order to avoid unnecessary repetition, the present application will not further describe various possible combination methods.

Claims

1. A composition suitable for an oil-in-water sunscreen system, characterized in that: The composition comprises polysorbate, polyethylene glycol methyl ether polydimethylsiloxane, dextrin palmitate and hydrolyzed royal jelly protein.

2. The composition according to claim 1, characterized in that Calculated by mass, the composition comprises 0.3-0.8 parts of polysorbate, 0.05-0.3 parts of polyethylene glycol methyl ether polydimethylsiloxane, 0.1-0.5 parts of dextrin palmitate and 0.05-0.3 parts of hydrolyzed royal jelly protein.

3. The composition according to claim 1, characterized in that The composition also includes glyceryl behenate; Calculated by mass, the composition comprises 0.3-0.8 parts of polysorbate, 0.05-0.3 parts of polyethylene glycol methyl ether polydimethylsiloxane, 0.1-0.5 parts of dextrin palmitate, 0.05-0.3 parts of hydrolyzed royal jelly protein and 0.1-0.8 parts of glyceryl behenate.

4. The composition according to claim 1, characterized in that The hydrolyzed royal jelly protein is prepared by a preparation method comprising the following steps: (1) mixing royal jelly with water, subjecting the mixture to microwave treatment, and filtering and collecting the filtrate after the microwave treatment to obtain a pre-treated solution; (2) mixing the pretreatment solution with the complex enzyme, performing an enzymatic hydrolysis reaction to obtain an enzymatic hydrolyzate, filtering the enzymatic hydrolyzate and collecting the filtrate to obtain hydrolyzed royal jelly protein; The complex enzyme in step (2) includes papain, trypsin and neutral protease.

5. The composition according to claim 4, characterized in that The material-liquid ratio of the royal jelly to water in step (1) is 1:5-1:20 g / mL; The temperature of the microwave treatment in step (1) is 50-80° C., the power of the microwave treatment is 200-500 W, and the time of the microwave treatment is 10-30 min.

6. The composition according to claim 4, characterized in that In step (2), the mass ratio of the pretreatment liquid to the complex enzyme is 100:1-100:5, the temperature of the enzymatic hydrolysis reaction is 30-50°C, and the time of the enzymatic hydrolysis reaction is 0.5-2 h; The mass ratio of papain, trypsin and neutral protease in step (2) is (1-3):(0.5-1):(0.1-0.5).

7. An oil-in-water sunscreen, characterized in that: The oil-in-water sunscreen comprises the composition of any one of claims 1 to 6, a physical sunscreen, a stabilizer, an emulsifier, a thickener, an antioxidant, water, an optional humectant, and an optional dispersant.

8. The oil-in-water sunscreen according to claim 7, characterized in that The physical sunscreen includes titanium dioxide modified with a surface treatment agent; The surface treatment agent includes any one of silica, aluminum hydroxide or triethoxyoctylsilane or a combination of at least two thereof.

9. The oil-in-water sunscreen according to claim 7, characterized in that The stabilizer includes octyl polymethylsiloxane and isononyl isononanoate; The mass ratio of the octyl polymethylsiloxane to isononyl isononanoate is 1:1-1:

4.

10. The oil-in-water sunscreen according to claim 7, characterized in that: The oil-in-water sunscreen comprises, by weight, 0.5-2.5 parts of the composition of any one of claims 1 to 6, 5-10 parts of a physical sunscreen, 5-10 parts of a stabilizer, 2-4 parts of an emulsifier, 0.3-2 parts of a thickener, 0.2-0.8 parts of an antioxidant, 5-10 parts of a humectant, 0.2-0.4 parts of a dispersant, and 60-85 parts of water.

Images