Colorectal cancer plasma circulating microbial marker, reagent, kit and application thereof

Through the screening method of colorectal cancer plasma circulating microbial markers, using specific microbial combinations and low-depth whole genome sequencing, the problems of high invasiveness and high cost of colon cancer screening in existing technologies are solved, and high sensitivity and specificity of early colon cancer detection are achieved.

CN120796473AActive Publication Date: 2025-10-17BEIJING XUTENG GENE TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510919563.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-03
Publication Date
2025-10-17
Estimated Expiration
2045-07-03

AI Technical Summary

Technical Problem

Existing colon cancer screening methods are highly invasive, costly, and lack sensitivity and specificity, making large-scale screening difficult.

Method used

Methods: We used eight circulating microbial markers for colorectal cancer in plasma, including Alternaria alternata, Ogatia philadelphica, Clostridium perfringens, R. hominis, Ralstonia solanacearum, Alternaria conjoints, Bacillus paralicheniformis, and Pseudomonas sichuanensis. Low-depth whole-genome sequencing was used to detect the microbial content in peripheral blood, and a risk scoring model was constructed for diagnosis.

Benefits of technology

It significantly improves the detection rate and accuracy of colorectal cancer, reduces costs, and is suitable for large-scale screening, especially for early colorectal cancer, with high sensitivity and specificity.

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Abstract

The invention discloses a colorectal cancer plasma circulating microbial marker, a reagent, a kit and application thereof, and belongs to the technical field of biomedical detection. The plasma circulating microbial marker for colorectal cancer comprises alternaria alternata, alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous alophilous The colorectal cancer plasma circulating microbial marker can be used for early screening of colorectal cancer, has relatively high sensitivity and specificity, and remarkably improves the accuracy and reliability of detection; the limitation of traditional ctDNA detection is broken through, and the detection rate of early colorectal cancer is improved. The colorectal cancer plasma circulating microbial marker in a colorectal cancer plasma sample is detected through low-depth whole genome sequencing, the requirement for depth in an experiment is reduced, the cost can be greatly reduced while high sensitivity and specificity are guaranteed, and the method is more suitable for large-scale screening.
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Citation Information

Patent Citations

  • Detection method and system for colorectal cancer

    CN109609639A

  • Microbial marker of colorectal cancer and application of marker

    CN109943636A

  • Probiotic composition for improving colorectal cancer symptoms and preparation method and application thereof

    CN115305228A

  • Method for diagnosing adenomas and / or colorectal cancer (CRC) based on analyzing the gut microbiome

    EP2955232A1

  • Biomarker combination for colorectal cancer early diagnosis and use thereof

    US20240254569A1

Cited By

  • Multi-cancer-species early screening method based on fragment omics and microbiological omics characteristics and application of multi-cancer-species early screening method

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