A mental health evaluation method and system based on brain region electrical stimulation

Abstract

The application discloses a mental health evaluation method and system based on brain area electric stimulation, relates to the technical field of medical and health information science, and creatively integrates brain area electric stimulation into mental health evaluation. The basic cognitive level and neural plasticity potential of a measured person are objectively quantified through comprehensive scores before and after brain area electric stimulation, so that corresponding suitable mental health evaluation test questions are selected based on the basic cognitive level and neural plasticity potential, and the precision, sensitivity of corresponding mental tests and the mental comfort of the measured person are significantly improved. A decay quantization model of a stimulating current from an electrode to the brain is given, the decay quantization model is used to accurately control the electric quantity, and the maximum beneficial effect is realized under the condition of guaranteeing health and safety. Historical data accumulated in the application process can be effectively used to solve medical problems, such as the influence of brain area electric stimulation on child neural development evaluation, early warning of mental illness and brain function reinforcement.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of healthcare informatics, in particular to a mental health evaluation method and system based on brain area electrical stimulation. BACKGROUND

[0002] The internationally recognized non-invasive brain stimulation technology is transcranial direct current stimulation technology. This technology continuously delivers low-intensity (≤2 mA) direct current to the cortex of a specific brain area, thereby changing the resting potential of the brain and promoting the improvement of individual cognitive ability. As a new and effective, simple and convenient non-invasive brain stimulation method, transcranial direct current stimulation technology has made remarkable research and development in improving the clinical symptoms of patients and improving the personal cognitive ability of healthy individuals.

[0003] Attention is a core element of individual cognitive ability and a prerequisite for performing higher cognitive functions. The efficiency, mode (such as bias, deviation, etc.), and stability of attention and cognitive ability deeply affect an individual's emotional experience, ability to cope with stress, and overall mental health level. The level of an individual's attention can be evaluated by the Shulte square test. The Shulte square is a square table with 5x5, a total of 25 small squares, filled with numbers 1 to 25 in random order. The testee needs to count from 1 to 25 as fast as possible and point out while reading. At the same time, the examiner records the time (or a computer program can be designed to count the time), the shorter the time, the stronger the attention of the testee.

[0004] Applying transcranial direct current stimulation technology to the Shulte square test can evaluate the brain potential of the testee by the time it takes for the testee to complete the Shulte square test before and after electrical stimulation. By combining the time it takes for the testee to complete the Shulte square test before electrical stimulation and the evaluation results of the testee's brain potential, a comprehensive score of the testee is obtained. Referring to the comprehensive score of the testee, further selecting appropriate mental health evaluation questions for the testee to test will significantly improve the scientificity and accuracy of the test. SUMMARY

[0005] The purpose of the present application is to provide a mental health evaluation method and system that introduces dynamic Shulte square testing and transcranial direct current stimulation technology, based on the comprehensive evaluation of the attention level and brain potential of the testee.

[0006] To solve the above technical problems, the technical solution adopted by the present application is as follows: a mental health evaluation method based on brain area electrical stimulation, comprising the following steps:

[0007] Step 1: Conduct three rounds of dynamic Schulte grid test on the test subject. After the test subject clicks on a square in the Schulte grid, the numbers in all the squares will be randomly redistributed. Record the time required for the test subject to complete each round of dynamic Schulte grid test, and take the average time of the three rounds of dynamic Schulte grid test as the previous reference time.

[0008] Step 2: Based on the subject's gender, age, body fat percentage, bone density, and head diameter data in three directions, calculate and determine the current application scheme for the subject's brain region electrical stimulation.

[0009] Step 3: Place the discharge electrodes for brain region electrical stimulation in the head area corresponding to the dorsolateral prefrontal cortex of the subject, and perform brain region electrical stimulation for 15 to 30 minutes according to the current application plan of the subject.

[0010] Step 4: After the subject completes the brain region electrical stimulation, the subject will undergo three rounds of dynamic Schulte grid test again, and the average time taken for these three rounds of dynamic Schulte grid test will be used as the subsequent reference time.

[0011] Step 5: Calculate the test subject's brain potential index based on the pre-reference time and post-reference time; divide the mental health assessment questions into three levels: high, medium, and low, with the high level having the most questions and the low level having the fewest; select the corresponding level of mental health assessment questions for the test based on the comprehensive score of the test subject's pre-reference time and brain potential index; evaluate the test subject's mental health based on the test results, and archive and retain the data and evaluation results throughout the test.

[0012] Furthermore, assuming that the electrical stimulation of the brain region begins after... t The electrical current that directly affects the brain of the test subject at any given moment is , t The unit is seconds; in Step 2, the current application scheme includes a static application scheme, a dynamic application scheme, and a pulse application scheme. When the current application scheme is a static application scheme, there is...

[0013] ,

[0014] In the formula, It is a constant with a value range of [0,2] and a unit of mA; when the current application scheme is a dynamic application scheme, we have

[0015] ,

[0016] In the formula, The base current has a range of [0.5, 1] ​​and is measured in mA. His the oscillation amplitude, with unit of mA; the base current and the oscillation amplitude need to satisfy the relationship: ; is the oscillation frequency, with unit of Hz; is the phase shift angle, with unit of rad; when the current application scheme is a pulse application scheme, there is

[0017] ,

[0018] In the formula, is the pulse peak current, with value range of [1.5, 2] and unit of mA; N is the burst number; P is the pulse interval period, with unit of s; w is the pulse width, with unit of s; is the carrier frequency, with unit of Hz.

[0019] Further, the current released by the discharge electrode at the time of t after the start of the brain area electrical stimulation is In step Step2, according to , the formula for calculating is

[0020] ,

[0021] In the formula, is the equivalent scalp conductivity, with unit of s / m; is the equivalent skull conductivity, with unit of s / m; is the equivalent scalp thickness, with unit of mm; is the equivalent skull thickness, with unit of mm; K is the compensation factor; G is the geometric factor, and the calculation formula of the geometric factor G is

[0022] ,

[0023] In the formula, Z is the head diameter factor, with unit of cm -1 ; is the reference head diameter, with unit of cm; is the longitudinal head diameter, and the longitudinal head diameter is the measured distance from the forehead to the back of the head of the measured person, with unit of cm; is the transverse head diameter, and the transverse head diameter is the measured distance between the two temples of the measured person, with unit of cm; is the vertical head diameter, and the vertical head diameter is the measured distance from the top of the head to the junction of the occipital bone and the spine of the measured person, with unit of cm.

[0024] Further, the equivalent scalp conductivity The calculation formula is

[0025] ,

[0026] In the formula, The baseline scalp conductivity is expressed in s / m. F Body fat percentage; b It is a scalp attenuation factor.

[0027] Furthermore, equivalent skull conductivity The calculation formula is

[0028] ,

[0029] In the formula, c The baseline skull conductivity is expressed in s / m. d This is the skull attenuation factor, in units of ; Bone mineral density, unit: .

[0030] Furthermore, equivalent scalp thickness The calculation formula is

[0031] ,

[0032] In the formula, E The reference scalp thickness is in mm. S This is the gender coefficient; when the subject is female, S When the value is 0, and the test subject is male, S The value is 1; A The age value of the test subject; The first gender factor, in mm; The first age factor is expressed in mm. This refers to body fat factor, measured in mm.

[0033] Furthermore, equivalent skull thickness The calculation formula is

[0034] ,

[0035] In the formula, J The baseline skull thickness is in mm. The second sex factor is expressed in mm. The second age factor is expressed in mm. Bone mineral density factor, unit: .

[0036] Furthermore, let the brain potential index of the test subjects be... ,but The calculation formula is

[0037] ,

[0038] In the formula, The previous reference time for the test subject is expressed in seconds. The post-reference time for the test subject is expressed in seconds.

[0039] Furthermore, let the combined score of the test subject's pre-reference time and brain potential indicators be: ,but The calculation formula is ,

[0040] In the formula, Rate the time, there are ,

[0041] Rate the time, there are ,

[0042] when When the value is greater than 0, advanced test questions are selected for the test subject to answer; when... When the value is 0, the test subject is given a medium-difficulty test question; when... When the value is less than 0, the test subject is given a lower difficulty level of questions to answer.

[0043] This invention also proposes a mental health evaluation system based on brain region electrical stimulation, employing the aforementioned method for mental health evaluation based on brain region electrical stimulation. The system includes a computer, an electrical stimulation device, and an interactive module. Both the electrical stimulation device and the interactive module are electrically connected to the computer. Both the electrical stimulation device and the interactive module interact with the computer for data exchange. The computer contains an assessment module and a storage module. The assessment module provides a dynamic Schulte grid test and a question-and-answer test. The storage module archives and retains the data and evaluation results throughout the testing process.

[0044] Compared with the prior art, the present application has the beneficial effects that: (1) the present application innovatively integrates brain area electrical stimulation into mental health evaluation, quantifies the basic cognitive level and neural plasticity potential of the measured person before and after brain area electrical stimulation through comprehensive scores, and selects corresponding suitable mental health evaluation test questions based on the above, which significantly improves the accuracy, sensitivity of corresponding psychological test and the psychological comfort of the measured person; (2) a quantitative model of the attenuation of the stimulating current from the electrode to the brain is given, and the amount of electricity is accurately controlled according to the quantitative model of the attenuation, so as to maximize the beneficial effects under the condition of health and safety; (3) the application of the present application not only proposes a new mental health evaluation method, but also effectively solves the medical problems such as the influence of brain area electrical stimulation on child neurodevelopment evaluation, early warning of mental illness and brain function strengthening through the accumulation of historical data in the process of using the method. BRIEF DESCRIPTION OF DRAWINGS

[0045] Figure 1 The figure is a step principle diagram of the mental health evaluation method based on brain area electrical stimulation of the present application.

[0046] Figure 2 The figure is a module principle diagram of the mental health evaluation system based on brain area electrical stimulation of the present application.

[0047] Figure 3 The figure is a layout area marking diagram of the discharge electrode of the present application.

[0048] In the figure: 1-computer; 2-electrical stimulation device; 3-interaction module; 4-evaluation module; 5-storage module. DETAILED DESCRIPTION

[0049] The technical solutions of the present application will be further described below in combination with the drawings and through specific embodiments, wherein the drawings are only used for exemplary description, and the representation is only a schematic diagram, not a physical diagram, and cannot be understood as a limitation on the present application; in order to better illustrate the embodiments of the present application, some components in the drawings may be omitted, enlarged or reduced, and do not represent the size of the actual product; for those skilled in the art, it is understandable that some well-known structures and their descriptions in the drawings may be omitted.

[0050] Figure 1 And Figure 2 The preferred embodiments of the present application are given.

[0051] As Figure 1 shown, the step principle of the mental health evaluation method based on brain area electrical stimulation is given, specifically:

[0052] Step Step1: three rounds of dynamic Shulte square test are conducted on the subject, and after the subject clicks a square in the Shulte square, the numbers in all the squares are randomly redistributed; the average time of the three rounds of dynamic Shulte square test is recorded as the reference time;

[0053] Step Step2: according to the gender, age, body fat rate, bone density and head diameter data in three directions of the subject, the current application scheme of the brain region electric stimulation of the subject is calculated and determined; the electric current directly acting on the brain of the subject at the time after the brain region electric stimulation starts is t , , t The unit is second; the current application scheme includes static application scheme, dynamic application scheme and pulse application scheme, when the current application scheme is the static application scheme, there is

[0054] ,

[0055] In the formula, is a constant, the value range is [0, 2], and the unit is mA; when the current application scheme is the dynamic application scheme, there is ,

[0056] In the formula, is the basic current, the value range is [0.5, 1], and the unit is mA; H is the oscillation amplitude, and the unit is mA; the basic current and the oscillation amplitude need to satisfy the relationship formula: ; is the oscillation frequency, the value range is [4, 50], and the unit is Hz; is the phase shift angle, and the unit is rad; when the current application scheme is the pulse application scheme, there is ,

[0057] In the formula, is the pulse peak current, the value range is [1.5, 2], and the unit is mA; N is the burst number, the value range is [180, 900]; P is the pulse interval period, the value range is [2, 5], and the unit is s; w is the pulse width, the value range is [0.1, 0.3], and the unit is s; is the carrier frequency, the value range is [100, 200], and the unit is Hz; the current application scheme in the embodiment selects the static application scheme, the value is constant 1.5 mA; the electric current released by the discharge electrode at the time after the brain region electric stimulation starts is t , In step 2, according to calculate The formula is ,

[0058] In the formula, Equivalent scalp conductivity, in units of S / m; Equivalent skull conductivity, in units of S / m; Equivalent scalp thickness, in mm; Equivalent skull thickness, in mm; K As a compensation factor, its value ranges from [0.1, 0.5]. In this embodiment, K The value is 0.3; G Geometric factor G The calculation formula is ,

[0059] In the formula, Z This is the head diameter factor, with a value range of [0.01, 0.03]. In this embodiment, Z The value is 0.01, and the unit is cm. -1 ; The reference head diameter has a value range of [50, 60]. In this embodiment, The value is 55, and the unit is cm; The longitudinal head diameter is the distance from the forehead to the back of the head of the subject, measured in cm. The transverse head diameter is the distance between the two temples of the subject, measured in cm. The vertical head diameter is the distance measured from the top of the subject's head to the point where the occipital bone connects to the spine, and the unit is cm.

[0060] Specifically, equivalent scalp conductivity The calculation formula is ,

[0061] In the formula, The baseline scalp conductivity is used, with a value range of [0.28, 0.33]. In this embodiment, The value is 0.3, and the unit is s / m; F Body fat percentage; b The scalp attenuation factor has a value range of [0.01, 0.03]. In this embodiment, b The value is set to 0.02; equivalent skull conductivity. The calculation formula is ,

[0062] In the formula, c The baseline skull conductivity is used, with a value range of [0.008, 0.015]. In this embodiment,c Value is 0.01, unit is s / m; d is the skull attenuation factor, value range is [0.01, 0.03], in the embodiment, d Value is 0.02, unit is ; is the bone density, unit is ; equivalent scalp thickness The calculation formula of is ,

[0063] In the formula, E is the reference scalp thickness, value range is [4.5, 5.5], in the embodiment, E Value is 5, unit is mm; S is the gender coefficient, when the measured person is female, S the value of is 0, when the measured person is male, S the value of is 1; A is the age value of the measured person; is the first gender factor, value range is [0.4, 0.6], in the embodiment, Value is 0.5, unit is mm; is the first age factor, value range is [0.01, 0.03], in the embodiment, Value is 0.02, unit is mm; is the body fat factor, value range is [0.02, 0.05], in the embodiment, Value is 0.03, unit is mm; equivalent skull thickness The calculation formula of is ,

[0064] In the formula, J is the reference skull thickness, value range is [6, 8], in the embodiment, J Value is 7, unit is mm; is the second gender factor, value range is [0.5, 0.8], in the embodiment, Value is 0.6, unit is mm; is the second age factor, value range is [0.02, 0.05], in the embodiment, Value is 0.03, unit is mm; is the bone density factor, value range is [1.8, 2.1], in the embodiment, Value is 2, unit is .

[0065] Step 3: Place discharge electrodes for brain region electrical stimulation in the head area corresponding to the dorsolateral prefrontal cortex of the subject. Perform brain region electrical stimulation for 15 to 30 minutes according to the current application plan of the subject. In this embodiment, the duration of brain region electrical stimulation is set to 20 minutes.

[0066] Step 4: After the subject completes the brain region electrical stimulation, the subject will undergo three rounds of dynamic Schulte grid test again, and the average time taken for these three rounds of dynamic Schulte grid test will be used as the subsequent reference time.

[0067] Step 5: Calculate the subject's brain potential index based on the pre-reference time and post-reference time. Let the subject's brain potential index be... ,but The calculation formula is ,

[0068] In the formula, The previous reference time for the test subject is expressed in seconds. The pre-reference time for the test subject is expressed in seconds (s). The mental health assessment test is divided into three levels: high, medium, and low. The high level test has the most questions (30), the medium level test has 20 questions (between high and low), and the low level test has the fewest questions (10). The combined score of the test subject's pre-reference time and brain potential index is defined as follows: ,but The calculation formula is

[0069] ,

[0070] In the formula, Rate the time, there are ,

[0071] Rate the time, there are ,

[0072] when When the value is greater than 0, advanced test questions are selected for the test subject to answer; when... When the value is 0, the test subject is given a medium-difficulty test question; when... When the value is less than 0, a lower-level test question is selected for the test subject to answer; based on the test results, the test subject's mental health is evaluated, and the data and evaluation results throughout the test are archived and retained.

[0073] like Figure 2As shown, the psychological health evaluation system based on brain area electric stimulation provided by the present application is electrically connected with the computer 1, and the electric stimulation device 2 and the interactive module 3 are both in data interaction with the computer 1; the interactive module 3 includes a computer display, a mouse, a keyboard and an audio device; the computer 1 is provided with an evaluation module 4 and a storage module 5; the evaluation module 4 is used for providing dynamic Shulte square test and answering test; and the storage module 5 is used for archiving and retaining the data and evaluation results of the whole test.

[0074] The working principle of the present application: the electric stimulation device 2 of the present embodiment adopts the high-precision transcranial direct current stimulation device (model 1300A&4×1-C3A) of the American Soterix Medical Company, and the brain area of the measured person is selected as the left dorsolateral prefrontal cortex, such as Figure 3 As shown, F3 is selected as the anode discharge electrode site, and the cathode sites are AF3, F1, F5 and FC3. The electric stimulation device 2 is directly connected with the computer 1 with Windows system, the measured person sits in front of the computer 1 before the test, inputs and confirms his personal information, and then performs the work of step Step1; at the same time, the psychological test teacher starts to perform the work of step Step2, and determines the current application scheme, after the measured person completes the work of step Step1, the psychological teacher performs the work of step Step3 according to the decision result of step Step2, after the work of step Step3 is completed, the measured person repeats the work of step Step1 once, that is, the work of step Step4, after the work of step Step4 is completed, the computer 1 automatically calculates the comprehensive score, at the same time, the measured person is allowed to rest for a few minutes, then the test of step Step5 is completed, after the measured person completes the test, the psychological test teacher gives the evaluation result and operates the computer 1 to save the information data of the whole test.

Claims

1. A mental health evaluation method based on brain region electrical stimulation, characterized in that: Step 1: The measured person is subjected to three rounds of dynamic Shulte square test, and after the measured person clicks a square in the Shulte square, the numbers in all squares are randomly redistributed; the average time of the three rounds of dynamic Shulte square test is taken as the reference time after recording the time required by the measured person to complete each round of dynamic Shulte square test; Step Step 2: According to the gender, age, body fat rate, bone density and head diameter data in three directions of the measured person, the current application scheme of the brain area electric stimulation of the measured person is calculated and determined; the direct current acting on the brain of the measured person after the start of the brain area electric stimulation is t , , t unit: second; The current application scheme includes static application scheme, dynamic application scheme and pulse application scheme, when the current application scheme is static application scheme, there is ， wherein is a constant constant, with a value range of [0, 2] in mA; when the current application scheme is a dynamic application scheme, there is ， In the formula, is a base current, with a value range of [0.5, 1] and a unit of mA; H is an oscillation amplitude, with a unit of mA; the base current and the oscillation amplitude need to satisfy the relationship formula: ; is an oscillation frequency, with a unit of Hz; is a phase shift angle, with a unit of rad; when the current application scheme is a pulse application scheme, there is ， In the formula, is the pulse peak current, with a value range of [1.5, 2] and a unit of mA; N is the burst number; P is the pulse interval period, with a unit of s; w is the pulse width in s; is the carrier frequency in Hz; and t is the current released by the discharge electrode at the time instant after the start of the electrical stimulation of the brain region, and is calculated according to the formula ​ ， wherein Geff is the equivalent scalp conductivity, in s / m; Geff is the equivalent skull conductivity, in s / m; Geff is the equivalent scalp thickness, in mm; Geff is the equivalent skull thickness, in mm; K is a compensation factor; G is a geometric factor, the geometric factor G is calculated as ， wherein, Z is the head diameter factor, in cm -1 ; is the reference head diameter, in cm; is the longitudinal head diameter, which is the measured distance from the forehead to the back of the head of the subject, in cm; is the transverse head diameter, which is the measured distance between the two temples of the subject, in cm; is the vertical head diameter, which is the measured distance from the top of the head to the junction of the occipital bone and the spine of the subject, in cm; Step 3: The discharge electrode for brain region electrical stimulation is arranged on the head region corresponding to the measured person's dorsolateral prefrontal cortex, and the brain region electrical stimulation is continuously carried out for 15-30 minutes according to the current application scheme of the measured person; Step 4: After the measured person completes the brain region electrical stimulation, the measured person is subjected to three rounds of dynamic Shulte square test again, and the average time of the three rounds of dynamic Shulte square test is taken as the reference time; Step 5: According to the reference time and the brain potential index of the measured person, the brain potential index of the measured person is calculated; The mental health evaluation test questions are divided into high, medium and low three levels, the high level test question quantity is the largest, and the low level test question quantity is the smallest; according to the reference time and the comprehensive score of the brain potential index of the measured person, the corresponding mental health evaluation test questions are selected for answering test, the mental health of the measured person is evaluated according to the answering test result, and the data and evaluation results of the whole test are archived and retained.

2. The mental health evaluation method based on brain region electrical stimulation according to claim 1, characterized in that: Equivalent scalp conductivity The formula for calculating the equivalent scalp conductivity is ， wherein Gref is the reference scalp conductivity in s / m; F Fb is the body fat fraction; b A is the scalp attenuation factor.

3. The mental health evaluation method based on brain region electrical stimulation according to claim 2, characterized in that: Equivalent skull conductivity The formula for calculating the equivalent skull conductivity is ， wherein c is the baseline skull conductivity in s / m; d is the skull attenuation factor in ; is the bone density in g / cm2 .

4. The mental health evaluation method based on brain region electrical stimulation according to claim 3, characterized in that: Equivalent scalp thickness The formula for calculating the equivalent scalp thickness is ， wherein, E is the baseline scalp thickness in mm; S is a gender coefficient, which has a value of 0 for a female subject, S is a gender coefficient, which has a value of 0 for a female subject, S is a gender coefficient, which has a value of 0 for a female subject, A is the age of the subject in years; is a first gender factor in mm; is a first age factor in mm; is a body fat factor in mm.

5. The brain region electrical stimulation-based mental health evaluation method of claim 4, wherein: Equivalent skull thickness The formula for calculating the equivalent skull thickness is ， wherein J is the baseline skull thickness in mm; is the second gender factor in mm; is the second age factor in mm; is the bone density factor in .

6. The mental health evaluation method based on brain region electrical stimulation according to claim 5, wherein the brain region electrical stimulation is provided by a transcranial magnetic stimulation device. The brain potential index of the subject is Then The calculation formula is ， In the formula, is the front reference time of the measured person, in seconds; is the rear reference time of the measured person, in seconds.

7. The mental health evaluation method based on brain region electrical stimulation according to claim 6, characterized in that: The front reference time of the measured person and the comprehensive score of the brain potential index are set as Then The calculation formula is ， In the formulae, For time score, there is ， For time score, there is ， When is greater than 0, high-grade test questions are selected for the examinee to answer; when is equal to 0, middle-grade test questions are selected for the examinee to answer; and when is less than 0, low-grade test questions are selected for the examinee to answer.

8. A mental health evaluation system based on brain region electrical stimulation, which adopts the mental health evaluation method based on brain region electrical stimulation in claim 7, comprising a computer (1), an electrical stimulation device (2), and an interaction module (3), characterized in that: The electrical stimulation device (2) and the interaction module (3) are electrically connected with the computer (1); the electrical stimulation device (2) and the interaction module (3) are in data interaction with the computer (1); the computer (1) is provided with an evaluation module (4) and a storage module (5); the evaluation module (4) is used for providing dynamic Shulte square test and answering test; the storage module (5) is used for archiving and retaining the data and evaluation results of the whole test.

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