Orthokeratology contact lens for wearer's eye

Abstract

The invention relates to an orthokeratology contact lens (L) for the eye of a wearer, the rear face of the back of the lens having at least one three-dimensional structure which extends along a loop-shaped or annular path around the geometric central axis of the lens, the three-dimensional structure is configured to provide a non-uniform spatial distribution of optical power along a loop or loop path or to reshape the cornea with a non-uniform spatial distribution of optical power along a loop or loop path, and wherein the three-dimensional structure is configured and arranged to: in use, receive a spatial distribution of optical power along the loop or loop path, and reshape the cornea with a non-uniform spatial distribution of optical power along the loop or loop path; the optical characteristics of the cornea of a wearer's eye are modified to have a non-uniform spatial distribution of optical power to reduce myopia by shaping the optical characteristics on the medial peripheral cornea of the wearer's eye in the form of non-uniform relatively positive power rings and negative power lenses made up of epithelial microlenses.

Description

Technical Field

[0001] The present invention relates to orthokeratology contact lenses for use in the eyes of wearers, the orthokeratology contact lenses having at least one three-dimensional structure for reshaping the cornea by means of a spatial distribution of non-uniform optical refractive power along a circumferential or annular path. Background Technology

[0002] Myopia is associated with diseases that can cause serious vision impairment, and myopia usually progresses because the axial length of the eye grows longer than the focal length of the eye's optical components.

[0003] High prevalence of myopia exists in many parts of the world. According to the World Health Organization (WHO), myopia is the leading cause of vision impairment, and it is projected that 50% of the global population will be myopic by 2025. A key concern is that myopia can progress to high myopia, defined as a refractive error exceeding six (6) or an axial length exceeding 26 mm. Without optical assistance, high myopia can severely impact daily life and increases the risk of retinal diseases, cataracts, and glaucoma. Severe visual complications can lead to blindness.

[0004] Optical devices are used to modify the eye's focus to provide a clearer picture at the plane of the retina. However, optical corrective devices such as ophthalmic contact lenses or regular contact lenses cannot prevent the eye's axial length from increasing, thus increasing the rate of myopia, because myopia may only be pseudo-myopia or symptomatic.

[0005] Recently, various contact lens designs have emerged in order to slow down the growth of children's eyeballs.

[0006] Orthokeratology (overnight contact lenses):

[0007] Orthokeratology, or ortho-k (OK) surgery, uses specially designed and custom-made lenses to temporarily reshape the eye to improve vision. OK lenses are worn overnight to reshape the front surface of the eye while you sleep.

[0008] Traditional rigid gas permeable lenses are double-curved lenses with a rear optical zone radius (BOZR) and a peripheral curvature. Orthokeratology (Ortho-k) lenses use specially designed gas permeable lenses to temporarily reshape the cornea, thereby improving vision. Basic standard Ortho-k lenses, or reverse geometry lenses, have three curvatures from the center to the periphery: the BOZR, the reverse curvature (with a curvature radius smaller than the BOZR and the corneal surface curvature), and the peripheral curvature. The reverse curvature assists in the corneal reshaping effect. To improve lens alignment, lenses are further modified into multi-curvature designs. An alignment curvature (AC) is introduced and combined between the reverse curvature and the peripheral curvature. This alignment curvature (AC) can also be divided into two curvatures (AC1 and AC2), thus forming a five-zone lens.

[0009] This combination of different curved sections controls the sagittal height of the lens, thus producing a reshaping effect. With the eye closed, the tear film beneath the lens exerts hydrodynamic positive and negative forces on the cornea, altering the treatment outcome. Positive forces are applied to flatten the central cornea, while negative forces resist traction on the intermediate-peripheral cornea. Through these two forces, epithelial cells are driven from the central cornea to the intermediate-peripheral cornea, creating a negative refractive power lens composed of epithelial microlenses to reduce myopia. The area of ​​the inverted curved section serves as a buffer for tissue redistribution. Modifications induced in the corneal epithelium result in optical zone correction, which has a intermediate-peripheral positive refractive power ring (PPR). The optical zone is associated with the central area where the refractive error is corrected, and the PPR surrounds this optical zone due to the change in curvature (smaller than the radius of the original cornea). Therefore, the refractive power of the central-peripheral cornea increases with a positive (positive) refractive power value, causing peripheral myopic defocus. Major later scientific discoveries showed that the subjects in the clear myopia control effect group had more adjustment in the positive refractive power ring within a 360° range [5]. In fact, studies have shown that the asymmetric positive refractive power ring has a physiological effect of inhibiting eyeball growth, thereby slowing down the trend of myopic eyeball growth.

[0010] Stoyan (US4952045) first proposed the concept of a three-segment curved corneal lens, which has: a basal curve, also known as a central curve or posterior curve, because it is located on the side in contact with the eye and is considered the posterior surface of the lens; a reverse curve, which creates a tear reservoir area and a peripheral curve area. According to this concept, the radius of curvature of the basal curve in the central region is greater than the radius of curvature of the corneal apex in myopic patients. Furthermore, the reverse curve is a loop-shaped curve with a radius of curvature smaller than that of the basal curve and the corresponding corneal region. The reverse curve and the underlying anterior corneal surface form a loop-shaped cavity or space called a tear reservoir, where tears accumulate and accommodate the thickening of the epithelial cell layer of the central peripheral cornea. The peripheral curve area is a loop-shaped curve or series of curves extending to the edge of the lens, connecting to the reverse curve and rising outwards. In the original three-section curvature design, the peripheral curvature formed a linear portion that contacted the anterior surface of the cornea. A major drawback of this design was that the lens was prone to movement and its centering was not accurate enough.

[0011] To enhance the centering of orthokeratology (Ortho-k) contact lenses, Reim (US5963297) proposed a four-segment curvature design: a base curvature zone, a reverse curvature zone, an adaptation curvature zone, and a surrounding curvature zone. The reverse curvature zone connects to the loop-shaped curvature segment in close contact with the corneal epithelial cell layer. This loop-shaped segment's contact with its corneal epithelial cell layer becomes a surface contact starting from the contact line in the three-segment curvature design, thereby enhancing the centering function of the Ortho-k contact lens. Based on this idea and to improve centering, M. Xinjie et al. described a four-quadrant asymmetric Ortho-k lens with an asymmetric peripheral curvature or adaptation curvature for stabilization purposes in CN114740635A.

[0012] Several studies have been published on the effects of orthokeratology (OK) contact lenses or special contact lenses on myopia development, and have shown that orthokeratology (OK) contact lenses or special contact lenses can slow the development of myopia in children. Recently, OK lenses have been considered the most effective optical treatment for myopia control. Although it does not completely stop the development of myopia, it has a two-year efficacy of 32% to 63% in axial length reduction compared to monofocal lenses and contact lenses. Special contact lenses for myopia control have achieved efficacy between 32% and 55%. It is unclear how long treatment should continue to maximize the benefit for each patient. However, it is known that the highest efficacy is achieved in the first six months, after which the efficacy may decrease due to visual cue adaptation [1]. The mechanism by which orthokeratology affects myopia development has not been fully elucidated. There are still many speculations about the underlying mechanism, and the mainstream hypothesis that orthokeratology or special contact lenses slow the development of myopia is based on the "peripheral refractive theory". This theory states that orthokeratology or contact lenses for myopia control reduce the stimuli of axial elongation by reducing peripheral hyperopic defocus and increasing peripheral myopic defocus [2].

[0013] The mechanism by which retinal imaging is altered and myopic defocus is based on changes in the so-called optical zone correction and intermediate peripheral positive refractive power ring. As the inventors have shown in their scientific study on reducing the diameter of the optical zone, the optical shape of the orthokeratology lens can be adjusted by designing it[3]. Surprisingly, the inventors found that different corneal morphologies can be shaped by adjusting specific areas in the design of the orthokeratology lens, resulting in excellent therapeutic effects. However, it is noteworthy that the improved myopia control effect of the smaller posterior optical zone diameter (BOZD) OK lens mainly occurs within the first six months (possibly due to retinal adaptation to the optical treatment), after which the differences in axial elongation between groups in the current lens become no longer significant[4].

[0014] In summary, existing orthokeratology contact lenses provide a stable, constant defocus or aberration input with limited long-term effectiveness.

[0015] CN110515218A discloses an orthokeratology contact lens that includes the features of the preamble of claim 1. However, the three-dimensional structure of the posterior or inner surface of the lens disclosed in this document is constructed and configured to improve the degree of parallelism and fit between the lens and the cornea, thereby addressing asymmetry and irregularities along the cornea. This is particularly achieved by adapting the geometry of different portions of the three-dimensional structure to the geometry of different regions of the wearer's cornea, for example, by providing different radii of curvature to those different portions, but each radius of curvature always coincides with the radius of curvature of the corresponding region of the cornea to which that portion is applied. This results in a tear fluid of the same thickness formed between each of these different portions, such as inverted / reverse curvature regions, and the corresponding corneal region, thus avoiding providing different myopia corrections to those different corneal regions.

[0016] Therefore, document CN110515218A teaches the opposite of providing orthokeratology contact lenses with a three-dimensional structure to modify the optical properties of the wearer's cornea by utilizing a non-uniform spatial distribution of optical refractive power, because the lenses disclosed in document CN110515218A are constructed and configured to prevent the above from happening, i.e., instead provide a uniform spatial distribution of optical refractive power.

[0017] Therefore, there is a need to provide an alternative to the prior art that covers the gaps found in the prior art by providing an orthokeratology contact lens that does not have the aforementioned defects.

[0018] References:

[0019] [1]Hiraoka, Takahiro MDMyopia Control with Orthokeratology:AReview.Eye&Contact Lens:Science&Clinical Practice 48(3):p 100-104,March2022.

[0020] [2]Lv,Huibin M.D.;Liu,Ziyuan M.D.;Li,Jiaxi M.D.;Wang,Yuexin M.D.;Tseng,Yulin M.D.;Li,Xuemin M.D..Long-Term Efficacy of Orthokeratology toControl Myopia Progression.Eye&Contact Lens:Science&Clinical Practice 49(9):p399-403,September 2023。

[0021] [3]PaunéJ,Fonts S,Rodríguez L,Queirós A.The Role of Back Optic ZoneDiameter in Myopia Control with Orthokeratology Lenses.J Clin Med.2021Jan 18;10(2):336。

[0022] [4]Guo B,Cheung SW,Kojima R,Cho P.Variation of Orthokeratology LensTreatment Zone(VOLTZ)Study:A2-year randomized clinical trial.OphthalmicPhysiol.Opt.2023Aug 6。

[0023] [5]Wang J,Yang D,Bi H,Du B,Lin W,Gu T,Zhang B,Wei R.A New Method toAnalyze the Relative Corneal Refractive Power and Its Association to MyopicProgression Control With Orthokeratology.Transl.Vis Sci Technol.2018Nov 30;7(6):17。

[0024] [6]Swarbrick HA.Orthokeratology review and update.Clin ExpOptom.2006;89(3):124–143。

[0025] [7] Chamberlain P, et al. Long-term Effect of Dual-focus Contact Lenseson Myopia Progression in Children: A6-year Multicenter Clinical Trial. OptomVis Sci. 2022Mar 1;99(3):204-212. Summary of the Invention

[0026] Therefore, the present invention relates to an orthokeratology contact lens for a wearer's eye, wherein the rear or inner surface of the back of the lens facing or in contact with the wearer's eye has at least one three-dimensional structure, the at least one three-dimensional structure extending along at least one circular or annular path around the geometric central axis of the lens.

[0027] Compared to existing orthokeratology contact lenses, in the orthokeratology lens of the present invention, the three-dimensional structure is configured to provide a non-uniform spatial distribution of optical refractive power along at least one circumferential or annular path, and the three-dimensional structure is configured and set such that, in use, in the case of myopia reduction, the optical properties of the wearer's cornea are modified to have a non-uniform spatial distribution of optical refractive power by shaping these optical properties on the intermediate peripheral cornea of ​​the wearer's eye into a lens with unequal relative positive refractive power rings and negative refractive power composed of epithelial microlenses.

[0028] In other words, the non-uniform spatial distribution of optical refractive power is set on the cornea by reshaping the wearer's cornea.

[0029] In some implementations, the three-dimensional structure is constructed and configured to achieve different tear thicknesses in the tear fluid formed between different regions of the three-dimensional structure and the corresponding corneal region to which the three-dimensional structure is applied.

[0030] The first implementation option is that the different developments of refractive power proceed from the geometric center in a positive relative value, or the different developments of refractive power are divided into two segments. In this case, for some implementations, the end of the central segment of the dual optical region may have a diameter between 0 mm and 4 mm, with a spherical curvature or an aspheric surface with very low asphericity, spanning a range of -0.5 to 0.9 units of eccentricity, and is the total diameter of the central optical region consisting of one or more developments of refractive power, up to a maximum diameter of 10 mm. The eccentricity of the optical region or the second outer portion is between -3 and +3, or follows a polynomial shape. In the case of lenses worn daily in ophthalmology, the continuous curvature will have a development towards a smaller radius of curvature; in the case of orthokeratology lenses, the continuous curvature will have a development towards a larger radius of curvature, or similarly, directly causing an increase in refractive power at the end of the optical region on the lens or on the wearer's cornea. In some embodiments, this radial development of refractive power will preferably be performed differently along the axis, preferably as a sinusoidal or cosine-shaped fluctuation after measurement along the outer periphery of the ring. In some embodiments, this fluctuation will establish itself within a period between 5 and 60 degrees as the nominal refractive power reaches its maximum and minimum values. This change in refractive power can be applied to continuous rings, wherein the final refractive power will increase and decrease successively until the end of the concentric rings, the preferred number of which is between one and six, and is shaped to have a width between 0.1 mm and 1.5 mm.

[0031] According to an embodiment, at least one three-dimensional structure includes a circular central region extending along a circular path, wherein different cross-sections of the circular central region taken along a corresponding radial plane including the geometric central axis of the contact lens have different curvature shapes.

[0032] In this implementation, the circular central region is a circular wavy central region, which includes: radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric central axis of the lens; and a transitional radial position located between the radial peaks and radial valleys.

[0033] Therefore, for this implementation, starting from a common starting point at the geometric center axis of the lens, for the circular central region, the cross-section including the peak has a curved shape with a maximum radial dimension, the cross-section including the valley has a curved shape with a minimum radial dimension, and the radial dimension of the cross-section including the transition radial position has a value between the maximum radius and the minimum radius.

[0034] In variations of this implementation, the end points of these sections are located at the same height (i.e., at corresponding points on a virtual plane perpendicular to the geometric center axis of the lens), such that the different curvature shapes differ only due to the radial dimensions of the radial peaks, radial valleys, and transitional radial positions of the circular central region.

[0035] In another variant of this implementation, the end points of these cross sections in the circular central region are located at different heights (i.e., at points on a virtual plane parallel to the geometric center axis of the lens), such that the different curvature shapes are due not only to the different radial dimensions of the radial peaks, radial valleys, and transitional radial positions, but also to the different heights of the end points of the cross sections in the circular central region.

[0036] For different variations of this implementation, the curved shape of the cross section in the circular wavy central region has the same or different radii of curvature.

[0037] In one embodiment, at least one three-dimensional structure includes at least one annular inversion region extending radially from the circular central region of the lens and extending along an annular path according to an annular inversion curved profile, wherein different cross-sections of the annular inversion curved profile taken along a corresponding radial plane including the geometric central axis of the contact lens have different curvature shapes and different lengths.

[0038] In this implementation, the annular reversal region is an annular wavy region, which includes: radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric center axis of the lens, and a transitional radial position located between the radial peaks and radial valleys.

[0039] In this implementation, for the annular reversal region, the cross-sections including the peaks have a curved shape with a maximum radius and / or a maximum radial dimension, the cross-sections including the valleys have a curved shape with a minimum radius and / or a minimum radial dimension, and the cross-sections including the transition radial position have a radius and / or radial dimension with a value between the maximum radius and / or radial dimension and the minimum radius and / or radial dimension.

[0040] In one variation of this implementation, all sections of the annular inversion region originate from corresponding radial starting points located at the same radius (i.e., radial dimension) from the geometrical central axis of the lens and at the same height (i.e., at corresponding points on a virtual plane perpendicular to the geometrical central axis of the lens). This would be the case for the annular non-wavy central region. For this variation, the different curvature shapes are solely due to the varying radii (i.e., radial dimensions) of the radial peaks, troughs, and transitional radial positions of the annular inversion region.

[0041] In another variation of this implementation, not all sections of the annular inversion region originate from corresponding radial starting points located at the same radius (i.e., radial dimension) and / or at the same height from the geometric center axis of the lens. This is the case for the wavy central region. In this variation, the different curvature shapes are due not only to the different radii (i.e., radial dimensions) of the radial peaks, troughs, and transitional radial positions, but also to the different radii (i.e., radial dimensions) and / or heights of the radial starting points of these sections of the annular inversion region.

[0042] According to another embodiment, at least one three-dimensional structure further includes an annular outward region that extends radially from an annular reverse region or another annular interconnect region and extends along an annular path according to an annular outward curved profile, wherein different cross-sections of the annular outward region along a corresponding radial plane including the geometric center axis of the contact lens have different curvature shapes and different lengths.

[0043] In this alternative implementation, the annular outward region is an annular wavy region, which includes: radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric center axis of the lens, and a transitional radial position located between the radial peaks and radial valleys.

[0044] In this implementation, for the annular outward region, the cross-sections including the peaks have a curved shape with a maximum radius, the cross-sections including the valleys have a curved shape with a minimum radius, and the cross-sections including the transition radial position have a radius between the maximum and minimum radii.

[0045] In a variant of this implementation, all sections of the annular outward region originate from corresponding radial starting points located at the same radius and height from the geometric center axis of the lens (i.e., at corresponding points on a virtual plane perpendicular to the geometric center axis of the lens). In this variant, the different curvature shapes arise solely from the varying radii of the radial peaks, radial valleys, and transitional radial positions of the annular outward region.

[0046] In another variation of this implementation, not all sections of the annular outward region originate from corresponding radial starting points located at the same radius and / or height from the geometric center axis of the lens. In this variation, the different curvature shapes are due not only to the different radii of the radial peaks, radial valleys, and transitional radial positions, but also to the different radii and / or heights of the radial starting points of the sections in the annular outward region.

[0047] As defined in some embodiments, implementations and variations thereof as described above, in some embodiments of the orthokeratology contact lens of the present invention, the end points of the cross-section of the circular central region (which are also the radial starting points of the cross-section of the annular inversion region) are not located at the same height, but at points on a virtual plane that is parallel to and perpendicular to the geometric central axis of the lens.

[0048] For a first construction embodiment of the orthokeratology lens of the present invention, the design includes an aspherical optical region or a spherical-aspherical optical region, wherein, depending on the radial axis, the radius at the edge of the optical region is larger or smaller relative to different meridians, resulting in different heights at the ends of the optical region located on different meridians. This height will be represented as a change after cyclic measurement in sine or cosine mode. The annular reversal region needs to be adjusted to meet the normal condition of the lens at the current developmental level, wherein the final sagittal height must match the calculated value for each individual. For some embodiments, the diameter of the optical region is between 3.50 mm and 8 mm.

[0049] The second structural embodiment of the orthokeratology lens of the present invention includes a spherical optical zone, an aspherical optical zone, or a spherical-aspherical optical zone with different radial distances along the meridian, the distance from which to the optical center fluctuates between 4 mm and 7 mm, forming a wave-like pattern along the entire 360°.

[0050] The third structural embodiment of the orthokeratology lens of the present invention begins with a circular optical region, a spherical optical region, an aspherical optical region, or a spherical-aspherical optical region, and an annular reverse / reverse region begins in its adjacent region. This annular reverse or reverse region will have end points located at different distances, and will be distributed in a wavy manner as observed in a circular pattern. The width is between 0.3 mm and 1.5 mm.

[0051] In some implementations, the three different exposed structural embodiments of the circular central region and the annular inversion region are followed by a series of at least one pair of additional annular regions, wherein in each pair of additional annular regions, the curvature of the cross-section of the first annular region in the additional annular region has a radius of curvature greater than that of the cross-section of the annular inversion region; and the curvature of the cross-section of the second annular region in the additional annular region has a radius of curvature smaller than that of the cross-section of the first additional annular region. This creates an annular cavity, groove, or slit, which is repeated two or three times with the paired additional annular regions until the final peripheral or edge annular region is reached.

[0052] It is important to note that this invention can be incorporated into any number of different orthokeratology contact lenses formed from any number of materials.

[0053] Regarding the different curve shapes mentioned above, according to the embodiments, they differ from each other in that they include at least one curved segment with a different radius of curvature and / or they have non-uniform aspherical curved portions, continuous curves, splines, or polynomial shapes.

[0054] For the aforementioned non-uniform spatial distribution of optical refractive power, in the implementation method, it is also an asymmetrical spatial distribution of optical refractive power along at least one circular or annular path.

[0055] In one implementation, the non-uniform spatial distribution of optical refractive power follows a sine or cosine pattern along 360° of at least one circular or annular path. Attached Figure Description

[0056] Some preferred embodiments of the invention will now be described with reference to the accompanying drawings. These drawings are provided for illustrative purposes only and are not intended to limit the scope of the invention. In accordance with common practice, components in the drawings are drawn to emphasize specific features, but the components are not drawn to scale.

[0057] Figure 1 schematically illustrates an embodiment of the lens of the present invention, which is an orthokeratology lens. A) By means of Figure 1B A) A side view of the lens taken from the cutting plane indicated by the 150° angled cutting plane line A-A'; B) A bottom view of the lens; C) A curve diagram showing the sagittal distance from the anterior surface of the eye to the posterior surface of the lens or to the tear film contour of the lens shown.

[0058] Figure 2 schematically illustrates another embodiment of the lens of the present invention, which is also an orthokeratology lens. A) By Figure 2B A) A side view of the lens taken from the cutting plane indicated by the 150° angled cutting plane line B-B'; B) A bottom view of the lens; C) A curve showing the tear film profile of the lens shown.

[0059] Figure 3 schematically illustrates another embodiment of the lens of the present invention, which is also an orthokeratology lens. A) By Figure 3B A) A side view of the lens taken from the cutting plane indicated by the 150° angled cutting plane line C-C' as shown in the diagram; B) A bottom view of the lens; C) A graph showing the radius of curvature of the lens shown.

[0060] Figure 4 Another embodiment of the lens of the present invention is schematically illustrated by a side cross-sectional view of the lens, which is also an orthokeratology lens. This side cross-sectional view is obtained by comparing... Figure 1B The cutting plane line A-A' is similar to the cutting plane line A-A', but is used for lenses with additional annular regions. The cutting plane is cut at a 150° angle.

[0061] Figure 5 schematically illustrates another embodiment of the orthokeratology contact lens of the present invention. A) By Figure 5B A) A side cross-sectional view of the lens taken by the cutting plane indicated by the 150° angled cutting plane line D-D'; B) A bottom view of the lens; C) A graph showing the radius of curvature of the lens shown.

[0062] Figure 6 The graphs represent the following: for the embodiment of the orthokeratology lens of the present invention, the height variation at the end of the optical region in a circular form along 360°; for the embodiment of the orthokeratology contact lens of the present invention, the refractive power fluctuates along the same meridian. Detailed Implementation

[0063] In this section, different embodiments of the orthokeratology contact lens of the present invention will be described with reference to the accompanying drawings.

[0064] In the illustrated embodiment, the back surface Lb of the orthokeratology contact lens L faces the wearer's eye. The orthokeratology contact lens L has at least one three-dimensional structure, which is constructed and configured to shape the optical properties of the wearer's cornea into a non-uniform spatial distribution of optical refractive power along a circular or annular path during use. In the case of myopia, these optical properties are shaped on the intermediate peripheral cornea of ​​the wearer's eye into a central lens with negative refractive power composed of epithelial microlenses and an uneven, relatively central peripheral ring of positive refractive power, thereby reducing myopia in the central region and inducing myopic defocus in the intermediate peripheral region.

[0065] For the embodiments shown in Figures 1 to 3, the orthokeratology lens L is based on a basic OK lens or a reverse geometry lens, and has the above three curved portions from the central portion to the outer periphery: BOZR 1; annular reverse region 2 or reverse curved portion 2; and annular outer peripheral region 5, or outer peripheral adaptive curved portion 5.

[0066] Specifically, for Figure 1A , Figure 1B and Figure 1C The embodiments shown are as follows: Figure 1B As shown, the three-dimensional structure includes: a circular, wavy central region 1 as a BOZR, the wavy central region 1 including radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric central axis of the lens L; and an annular reversal region 2 as a reversal curve portion, the annular reversal region 2 extending radially from the circular, wavy central region 1 and extending along an annular path according to the annular reversal curve profile portion.

[0067] like Figure 1B As shown, in the illustrated embodiment, the radial peaks and radial valleys of the circular wavy central region 1 alternate at an angle every 30° along 360°, but for the embodiment not shown, an angle other than 30° between 10° and 90° may also be used.

[0068] Figure 1A A cross section is shown, comprising a left cross section portion passing through one of the radial valleys and a right cross section portion passing through one of the radial peaks, wherein the angle between those cross sections is 150°.

[0069] The left cross-section includes a section 1a of a circular, wavy central region 1. The radial dimension of section 1a is shorter than that of section 1b, i.e., X1. <X2。

[0070] Furthermore, since X1+X3=X2+X4, the radial dimension of section 2a of the annular inversion region 2 is greater than the radial dimension of section 2b, i.e., X3>X4.

[0071] These radial dimensions make:

[0072] - The curved shape of section 1a has the minimum radial dimension, the curved shape of section 1b has the maximum radial dimension, and the radial dimension of the section at the transition radial position has a value between the minimum and maximum radius; and

[0073] - The curved shape of section 2a has the minimum radius (i.e., radius of curvature), the curved shape of section 2b has the maximum radius (i.e., radius of curvature), and the radius of the section at the transition radial position has a value between the minimum radius and the maximum radius (i.e., radius of curvature).

[0074] In the illustrated embodiment, the radii of curvature of the curved shapes of these sections 1a and 1b, as well as the radii of curvature at the transition radial position, are the same. However, alternatively, the curved shape of section 1a has the smallest radius of curvature, the curved shape of section 1b has the largest radius of curvature, and the radius of curvature of the section at the transition radial position has a value between the smallest and the largest radius.

[0075] Figure 1C The above content is represented by a graph, which shows... Figure 1A and Figure 1B The tear film contour of the lens L shown in the diagram specifically illustrates (when placed on the wearer's eye) the distance from the corneal plane of the lens relative to the distance from the apex of the lens.

[0076] like Figure 1A and Figure 1CAs shown, in the illustrated embodiment, the end points of sections 1a and 1b are located at different heights (i.e., at points on parallel virtual planes perpendicular to the geometric center axis of lens L) and at different radial distances, and therefore the starting points of sections 2a and 2b are located at different heights (i.e., at points on parallel virtual planes perpendicular to the geometric center axis of lens L) and at different radial distances. The end points of sections 2a and 2b are also located at the same height and the same radial distance, such that the different curvature shapes are due to the different radii of the curvature shapes of sections 2a, 2b and the sections at the transition radial positions, and due to the different radial dimensions X1, X2, X3, X4 and the aforementioned different heights.

[0077] for Figure 2A , Figure 2B and Figure 2C The embodiments shown are as follows: Figure 2B The three-dimensional structure shown includes: a circular (non-wavy) central region 1; and an annular wavy inversion region 2, which extends radially from the circular central region 1 and extends along an annular path according to an annular inversion curved profile, the annular inversion curved profile including radial peaks and radial valleys located on concentric geometric circumferences surrounding the geometric central axis of the lens L.

[0078] like Figure 2B As shown, in the illustrated embodiment, the radial peaks and radial valleys of the annular wavy inverted region 2 alternate at an angle every 30° along 360°, but for the embodiment not shown, angles other than 30° may also be used.

[0079] Figure 2A A cross-section is shown, comprising a left cross-section portion passing through one of the radial valleys and a right cross-section portion passing through one of the radial peaks, with an angle of 150° between these cross-sections.

[0080] The left cross section includes a cross section 1a of the circular central region 1. The radial dimension of cross section 1a is the same as that of cross section 1b, i.e., X5 = X6.

[0081] In this case, the radial dimension of section 2a of the annular wavy inversion region 2 is shorter than the radial dimension of section 2b, i.e., X7. <X8。

[0082] These radial dimensions make:

[0083] - The bending shapes of sections 1a and 1b are equal; and

[0084] - The bending radius of section 2a has the minimum radius (i.e., radius of curvature), the bending shape of section 2b has the maximum radius (i.e., radius of curvature), and the radius (i.e., radius of curvature) of the section at the transition radial position has a value between the minimum and maximum radius.

[0085] Figure 2C The above content is represented by a graph, showing... Figure 2A and Figure 2B The tear film contour of the lens L shown in the diagram specifically illustrates (when placed on the wearer's eye) the distance from the corneal plane of the lens relative to the distance from the apex of the lens.

[0086] like Figure 2A and Figure 2C As shown, for the illustrated embodiment, the end points of sections 1a and 1b are located at the same height (i.e., at corresponding points on a virtual plane perpendicular to the geometric center axis of the lens L) and at the same radial distance. Consequently, the starting points of sections 2a and 2b (and section 2c at the transition radial position) are located at the same height (i.e., at corresponding points on a virtual plane perpendicular to the geometric center axis of the lens L) and at the same radial distance. The end points of sections 2a and 2b are also located at the same height but at different radial distances, such that the different curvatures of 2a, 2b, and 2c are only due to the different radii of the radial valleys, radial peaks, and transition radial positions of the annular wavy inversion region 2.

[0087] for Figure 3A , Figure 3B and Figure 3C The embodiments shown are as follows: Figure 3B As shown, the three-dimensional structure includes a circular (non-wavy) central region 1 and an annular (non-wavy) reverse region 2, which extends radially from the circular central region 1 and extends along an annular path according to the annular reverse curved profile.

[0088] Figure 3A A cross-section is shown, which includes a left cross-section portion and a right cross-section portion, with an angle of 150° between the left and right cross-section portions.

[0089] The left cross section includes a cross section 1a of the circular central region 1. The radial dimension of cross section 1a is the same as that of cross section 1b, that is, X9 = X10.

[0090] Furthermore, since X9+X11=X10+X12, the radial dimension of section 2a is also the same as the radial dimension of section 2b, that is, X11=X12.

[0091] However, the heights of sections 2a and 2b in the annular reversal region 2 are different, that is, the starting points of sections 2a and 2b are located at different heights (i.e., at different corresponding points on the virtual plane perpendicular to the geometric center axis of the lens L). In particular, the height of section 2a is higher than the height of section 2b, i.e., V1>V2.

[0092] These heights make:

[0093] - The bending shape of section 1a has a maximum radius, and the bending shape of section 1b has a minimum radius; and

[0094] - The curved shape of section 2a has the maximum radius, and the curved shape of section 2b has the minimum radius.

[0095] Figure 3C The above content is represented by a graph, showing... Figure 3A and Figure 3B The radius of curvature of the lens L shown is relative to the distance from the vertex of the lens. The segments 1a and 1b can conform to a single aspherical curve, a continuous multi-bend section, or a polynomial shape, wherein the continuous multi-bend section is connected by tangents to form successive and continuous bends.

[0096] like Figure 3A and Figure 3C As shown, in the illustrated embodiment, the end points of sections 1a and 1b are located at different heights and at the same radial distance, and the starting points of sections 2a and 2b are located at different heights and at the same radial distance, while the end points of sections 2a and 2b are located at the same height and at the same radial distance, such that the different bending shapes of 2a, 2b, and 2c are only due to these different heights.

[0097] exist Figure 4 The image shows another orthokeratology lens L according to the invention, which is based on the above-described multi-curve design, and in particular, the orthokeratology lens L includes an adaptive curvature portion between the inverted curvature portion and the peripheral curvature portion, the adaptive curvature portion being divided into curvature portions.

[0098] In particular, Figure 4 The embodiments shown include those with Figure 1A , Figure 1B , Figure 1C The implementation has the same features regarding the following aspects: an annular wavy central region 1; an annular (non-wavy) reverse region 2; and a first curved portion adapted to be curved, the first curved portion being in the form of an annular outward region extending radially from the annular reverse region 2, in this case extending radially from another annular interconnect region, and the annular outward region extending along an annular path according to the annular outward curved profile.

[0099] Different sections 3a and 3b of the annular outward region, taken along the corresponding radial plane including the geometric center axis of the contact lens L, have different curvature shapes.

[0100] In addition, for Figure 4 In one embodiment, the lens L further includes an additional curved portion of the fitting portion, the additional curved portion being in the form of an additional annular region, the additional annular region extending radially from the annular outward region, in this case extending radially from the additional annular interconnection region, and the additional annular region extending along a corresponding annular path according to the annular outward curved profile portion.

[0101] The other annular regions, with their different cross-sections 4a, 4b, 5a, 5b, 6a, and 6b taken along the corresponding radial planes that include the geometric center axis of the contact lens L, have different curvature shapes.

[0102] like Figure 4 As shown, in the illustrated embodiment, the radii of curvature of the curved shapes of sections 3a and 3b are larger than the radii of curvature of the curved shapes of sections 2a and 2b, respectively; the radii of curvature of the curved shapes of sections 4a and 4b are smaller than the radii of curvature of the curved shapes of sections 3a and 3b, respectively; the radii of curvature of the curved shapes of sections 5a and 5b are smaller than the radii of curvature of the curved shapes of sections 4a and 4b, respectively; and the radii of curvature of the curved shapes of sections 6a and 6b are smaller than the radii of curvature of the curved shapes of sections 5a and 5b, respectively.

[0103] The different curvatures of sections 3a, 3b, 4a, 4b, 5a, 5b, 6a, and 6b can be created in the same or similar manner as described regarding sections 2a and 2b (wavy annular regions, different starting or ending points, etc.).

[0104] The curved shapes of sections 3a, 3b, 4a, 4b, 5a, 5b, 6a, and 6b can be created in the same or similar manner as described regarding the front surface of day contact lenses.

[0105] Figure 5A , Figure 5B and Figure 5C The implementation method is Figure 1A , Figure 1B , Figure 1C and Figure 2A , Figure 2B , Figure 2C A combination of implementation methods.

[0106] Specifically, for Figure 5A , Figure 5B and Figure 5C The embodiments shown are as follows: Figure 5B The implementation shown is similar to Figure 1A , Figure 1B and Figure 1C The implementation method is similar, and the three-dimensional structure includes: a circular wavy central region 1 as the BOZR, the circular wavy central region 1 including radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric central axis of the lens L; and an image Figure 2A , Figure 2B and Figure 2C As in the same implementation, the annular wave-shaped reversal region 2, which is the reversal bending portion, extends radially from the circular wave-shaped central region 1 and extends along an annular path according to the annular reversal bending profile, which includes radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric central axis of the lens L.

[0107] like Figure 5B As shown, in the illustrated embodiment, the radial peaks and radial valleys of both the circular wavy central region 1 and the annular wavy reverse region 2 alternate at an angle every 30° along 360°, but for the embodiment not shown, angles other than 30° may also be used.

[0108] Figure 5A A cross-section is shown, comprising a left cross-section portion passing through a pair of radial valleys (one being the radial valley of the circular wavy central region 1 and the other being the radial valley of the annular wavy inverted region 2) and a right cross-section portion passing through a pair of radial peaks (one being the radial peak of the circular wavy central region 1 and the other being the radial peak of the annular wavy inverted region 2), wherein the angle between these cross-sections is 150°.

[0109] The left cross-section includes a cross-section 1a of a circular wavy central region 1, which has a radial dimension smaller than that of cross-section 1b, i.e., X13 < X14.

[0110] In this case, the radial dimension of section 2a of the annular wavy inversion region 2 is larger than the radial dimension of section 2b, that is, X15>X16.

[0111] These dimensions make:

[0112] - The curved shapes of sections 1a and 1b have the same radius (but different radial dimensions, as described above); and

[0113] - The bending shapes of section 2a and section 2b have different radii, and the radius of the section at the transition radial position has a value between these different radii.

[0114] Figure 5C The above content is illustrated using a graph, showing... Figure 5A and Figure 5B The tear film contour of the lens L shown in the figure, in particular, shows (when placed on the wearer's eye) the distance from the corneal plane of the lens relative to the distance from the apex of the lens.

[0115] like Figure 5A and Figure 5C As shown, for the illustrated embodiment, the end points of sections 1a and 1b are located at different heights (i.e., at points on a parallel virtual plane perpendicular to the geometric center axis of lens L) and at different radial distances. Consequently, the starting points of sections 2a and 2b are located at different heights (i.e., at points on a parallel virtual plane perpendicular to the geometric center axis of lens L) and at different radial distances. Furthermore, the end points of sections 2a and 2b are located at the same height but at different radial distances. This results in different curvature shapes due to the following: the radii of the radial valleys, radial peaks, and transition radial positions of the circular wavy central region 1 and the annular wavy reverse region 2 are different, and the aforementioned heights and radii of the curvature shapes of sections 2a and 2b and the transition radial positions are different.

[0116] at last, Figure 6 A graph is shown that, for the embodiment of the orthokeratology lens of the present invention, the height at the end of the circular optical region varies along 360°; and for the embodiment of the orthokeratology contact lens of the present invention, the refractive power fluctuates along the same meridian.

[0117] Those skilled in the art can make changes and modifications to the described embodiments without departing from the scope of the invention as defined in the appended claims.

Claims

1. An orthokeratology contact lens (L) for use in a wearer's eye, wherein, The posterior surface (Lb) of the lens (L) facing or in contact with the wearer's eye has at least one three-dimensional structure extending along at least one circular or annular path around the geometric central axis of the lens (L). The three-dimensional structure is characterized by being configured to provide a non-uniform spatial distribution of optical refractive power along the at least one circular or annular path. Furthermore, the three-dimensional structure is configured and arranged such that, in use, by shaping the optical properties of the wearer's eye's intermediate peripheral cornea into a lens (L) with unequal relative positive refractive power rings and negative refractive power composed of epithelial microlenses, the optical properties of the wearer's eye's cornea are modified to have the non-uniform spatial distribution of optical refractive power, thereby reducing myopia.

2. The lens (L) according to any one of the preceding claims, wherein, The at least one three-dimensional structure includes a circular central region (1, Lc) extending along a circular path, wherein different sections (1a, 1b) of the circular central region (1) taken along a corresponding radial plane including the geometric central axis of the contact lens (L) have different curvature shapes.

3. The lens (L) according to claim 2, wherein, The circular central region (1, Lc) is a circular wavy central region, which includes radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric central axis of the lens (L).

4. The lens (L) according to claim 3, wherein, The radial peaks and radial valleys of the circular, wavy, inverted region (1) alternate at an angle every 30° along a 360° radius.

5. The lens (L) according to any one of claims 2 to 4, wherein, In the orthokeratology contact lens (L), the at least one three-dimensional structure includes at least one annular inversion region (2), which extends radially from the annular central region (1) of the lens (L) and extends along an annular path according to the annular inversion curved profile, wherein different sections (2a, 2b) of the annular inversion curved profile taken along the respective radial plane including the geometric central axis of the contact lens (L) have different curvature shapes.

6. The lens (L) according to claim 5, wherein, The at least one annular inversion region (2) is an annular wavy region, the annular wavy region comprising radial peaks and radial valleys located at corresponding concentric geometric circumferences around the geometric central axis of the lens (L).

7. The lens (L) according to claim 6, wherein, The radial peaks and radial valleys of the annular wavy region (2) alternate at an angle every 30° along 360°.

8. The lens (L) according to claim 5, wherein, At least one of the annular inverted regions (2) is an annular non-wavy region.

9. The lens (L) according to claim 5, 6, 7 or 8, wherein, The at least one three-dimensional structure further includes an annular outward region that extends radially from the at least one annular reverse region (2) or another annular interconnect region and extends along an annular path according to the annular outward curved profile, wherein different sections (3a, 3b) of the annular outward region along the respective radial plane including the geometric center axis of the contact lens (L) have different curvature shapes.

10. The lens of claim 9, further comprising an additional annular region extending radially from the annular outward region or an additional annular interconnecting region and extending along an annular path according to the annular outward curved profile, wherein, The bending shape of the cross section (2a, 2b) of the at least one annular inverted region (2) has a larger radius of curvature than the bending shape of the cross section (3a, 3b) of the annular outward region, and the bending shape of the cross section (4a, 4b) of the other annular region has a smaller radius of curvature than the cross section (3a, 3b) of the annular outward region.

11. The lens (L) according to any one of claims 2 to 10, wherein, The end points of those sections of the annular central region (1) are not at the same height, but at different heights of corresponding points on a virtual plane that is parallel to the geometric center axis of the lens (L), which provides the different curvature shapes.

12. The lens (L) according to any one of claims 2 to 11, wherein, The different bending shapes differ from each other in that they include at least one bending segment with a different radius of curvature.

13. The lens (L) according to any one of claims 2 to 12, wherein, The different bending shapes differ from each other in that they have non-uniform aspherical bending portions, continuous bending lines, serrated portions, or polynomial shapes.

14. The lens (L) according to any one of the preceding claims, wherein, The non-uniform optical refractive power spatial distribution is also an asymmetric optical refractive power spatial distribution along the at least one circular or annular path.

15. The lens (L) according to any one of the preceding claims, wherein, The non-uniform spatial distribution of optical refractive power follows a sine or cosine pattern along 360° of the at least one circular or annular path.

Images