Toothpaste with caries prevention effect and preparation method thereof

Abstract

The invention relates to toothpaste with an anti-caries effect and a preparation method of the toothpaste. The toothpaste is prepared from the following raw materials: an anti-caries agent, a freckle removing agent, a humectant, a foaming agent and a solvent. The anti-caries agent comprises hydroxyapatite, sodium monofluorophosphate and casein phosphopeptides. The invention creatively discovers that hydroxyapatite, sodium monofluorophosphate or casein phosphopeptides are lack of any one of hydroxyapatite, sodium monofluorophosphate and casein phosphopeptides, and the whole streptococcus mutans removal effect of the toothpaste is reduced, which indicates that hydroxyapatite, sodium monofluorophosphate and casein phosphopeptides have obvious synergistic effects in the aspects of removing streptococcus mutans and preventing and treating decayed teeth. The toothpaste can efficiently remove streptococcus mutans, has the effect of preventing decayed teeth, and also has the effects of removing dental plaque and whitening.

Description

Technical Field

[0001] This invention belongs to the field of daily necessities technology, specifically relating to a toothpaste with anti-caries effect and its preparation method. Background Technology

[0002] In the field of oral health, dental caries is an extremely common and harmful disease, with a high incidence rate across all age groups. Dental caries primarily results from pathogenic bacteria such as Streptococcus mutans in the oral cavity breaking down food debris and producing acidic substances. These acidic substances gradually erode tooth enamel, leading to demineralization and the formation of cavities. If left untreated, caries can progress further, causing pulpitis, periapical periodontitis, and even tooth loss, severely impacting chewing function and overall health.

[0003] CN1318362A discloses a toothpaste for preventing tooth decay, comprising, by weight percentage: 20-30% toothpaste moisturizer, 1.0-1.3% toothpaste binder, 0.2-0.35% toothpaste sweetener, 0.3-0.9% toothpaste corrosion inhibitor, 0.005-0.5% magnolol and / or magnolol isomers, 48-52% toothpaste abrasive, 1.8-2.5% toothpaste foaming agent, 1.0-1.4% fragrance, with the balance being water. This toothpaste has the effects of preventing tooth decay and eliminating bad breath, with no side effects.

[0004] CN117224449A discloses a safe and gentle toothpaste for children to prevent tooth decay. It contains no preservatives, and the active ingredients that provide antibacterial and preservative effects are all plant extracts with antibacterial activity, such as extracts of Hibiscus mutabilis flower and Ginkgo biloba. These extracts contain various active substances such as flavonoids, ginkgolides, diterpenoids, and polyphenols, thus exhibiting broad-spectrum and excellent in vitro antibacterial and antioxidant activity, enabling them to play an antibacterial and preservative role. Furthermore, extracts from lemon peel, as well as Hibiscus mutabilis flower and Ginkgo biloba extracts, have inhibitory effects on cariogenic Streptococcus mutans, thus playing a role in preventing tooth decay and providing adjunctive treatment.

[0005] However, current anti-caries toothpastes often have complex ingredients and limited efficacy. Therefore, developing a toothpaste that can effectively prevent and treat cavities while also removing plaque and improving whitening effects has become one of the urgent technical challenges to be addressed. Summary of the Invention

[0006] To address the shortcomings of existing technologies, the present invention aims to provide a toothpaste with anti-caries properties and its preparation method. This toothpaste effectively removes Streptococcus mutans, thus preventing tooth decay, while also removing plaque and whitening the teeth.

[0007] To achieve this objective, the present invention adopts the following technical solution:

[0008] In a first aspect, the present invention provides a toothpaste with anti-caries effect, wherein the raw materials for preparing the toothpaste include anti-caries agent, stain remover, humectant, foaming agent and solvent.

[0009] The caries-preventing agent includes hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide.

[0010] Hydroxyapatite is a naturally occurring mineral whose main components are calcium, phosphorus, and oxygen. It is a major component of tooth enamel and dentin, and can fill enamel cracks, form a protective film, help prevent cavities, and relieve sensitivity. Sodium monofluorophosphate is an ionic compound composed of sodium ions and monofluorophosphate ions. The fluoride ions it releases can enhance the acid resistance of tooth enamel and have low irritation. Casein phosphopeptide contains multiple phosphorylated serine residues, which can bind calcium and phosphorus, providing raw materials for tooth remineralization.

[0011] This invention creatively discovers that the absence of any one of hydroxyapatite, sodium monofluorophosphate, or casein phosphopeptide reduces the overall effectiveness of toothpaste in removing Streptococcus mutans, indicating that hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide have a significant synergistic effect in removing Streptococcus mutans and preventing tooth decay.

[0012] Preferably, the raw materials for preparing the toothpaste, by weight, include 5-8 parts of anti-caries agent, 1-3 parts of stain remover, 10-30 parts of humectant, 0.5-3 parts of foaming agent, and 20-80 parts of solvent.

[0013] Specifically, for 5-8 portions, the specific point values ​​can be 5, 6, 7, 8, etc.; for 1-3 portions, the specific point values ​​can be 1, 1.5, 2, 2.5, 3, etc.; for 10-30 portions, the specific point values ​​can be 10, 15, 20, 25, 30, etc.; for 0.5-3 portions, the specific point values ​​can be 0.5, 1, 1.5, 2, 2.5, 3, etc.; and for 20-80 portions, the specific point values ​​can be 20, 30, 40, 50, 60, 70, 80, etc.

[0014] Preferably, the mass ratio of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide is (3-5):(1-3):(0.5-1).

[0015] Among them, the specific point values ​​for 3-5 can be 3, 3.3, 3.6, 3.9, 4.2, 4.5, 4.8, 5, etc.; the specific point values ​​for 1-3 can be 1, 1.3, 1.6, 1.9, 2.2, 2.5, 2.8, 3, etc.; and the specific point values ​​for 0.5-1 can be 0.5, 0.6, 0.7, 0.8, 0.9, 1, etc.

[0016] Based on the significant synergistic effect of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide in removing Streptococcus mutans and preventing tooth decay, controlling the mass ratio of the three to (3-5):(1-3):(0.5-1) can better enhance the toothpaste's anti-caries effect.

[0017] Preferably, the spot-removing agent includes calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside.

[0018] Calcium glycerol phosphate is a compound formed by the combination of the hydroxyl groups of glycerol and phosphoric acid to form a phosphate ester, which then combines with calcium ions. It can relieve tooth sensitivity. Sodium lauryl sulfate is a sodium salt formed by the reaction of lauryl alcohol and sulfuric acid. Its structure contains long-chain alkyl groups and sulfate ester groups, which can reduce surface tension and have a foaming effect. Lauryl glucoside is formed by lauryl alcohol and glucose linked by glycosidic bonds. It can penetrate into the interior of dental plaque and has little irritation to the oral mucosa.

[0019] This invention creatively discovers that the absence of any one of calcium glycerophosphate, sodium lauryl sulfate, or lauryl glucoside significantly reduces the overall stain removal effect of toothpaste, indicating that calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside have a significant synergistic effect in removing tooth stains.

[0020] Preferably, the mass ratio of the calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside is (0.5-1):(0.1-0.5):(1-5).

[0021] Among them, the specific point values ​​in 0.5-1 can be 0.5, 0.6, 0.7, 0.8, 0.9, 1, etc.; the specific point values ​​in 0.1-0.5 can be 0.1, 0.2, 0.3, 0.4, 0.5, etc.; and the specific point values ​​in 1-5 can be 1, 2, 3, 4, 5, etc.

[0022] Based on the synergistic effect of calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside in removing tooth stains, controlling the mass ratio of the three in the range of (0.5-1):(0.1-0.5):(1-5) can better enhance the stain removal effect of toothpaste.

[0023] Preferably, the moisturizer includes any one or a combination of at least two of sorbitol, xylitol, or glycerin.

[0024] Preferably, the foaming agent comprises any one or a combination of at least two of sodium lauryl glucocarboxylate, sodium citrate, or sorbic acid.

[0025] Preferably, the solvent includes water.

[0026] Preferably, the raw materials for preparing the toothpaste further include any one or a combination of at least two of the following: thickeners, chelating agents, viscosity modifiers, or taste improvers.

[0027] Preferably, the raw materials for preparing the toothpaste, by mass parts, further include any one or a combination of at least two of the following: 0.1-0.5 parts thickener, 0.5-1 parts chelating agent, 10-15 parts viscosity modifier, and 0.1-0.5 parts taste improver.

[0028] Specifically, the point values ​​for 0.1-0.5 parts can be 0.1, 0.2, 0.3, 0.4, 0.5, etc.; the point values ​​for 0.5-1 parts can be 0.5, 0.6, 0.7, 0.8, 0.9, 1, etc.; and the point values ​​for 10-15 parts can be 10, 11, 12, 13, 14, 15, etc.

[0029] Preferably, the thickener comprises methyl vinyl ether-maleic anhydride copolymer (PVM / MA copolymer) and / or lecithin.

[0030] Preferably, the chelating agent comprises tetrasodium pyrophosphate.

[0031] Preferably, the viscosity modifier comprises any one or a combination of at least two of hydrated silica, xanthan gum, or cellulose gum.

[0032] Preferably, the taste improver includes sodium saccharin.

[0033] Secondly, the present invention provides a method for preparing a toothpaste with anti-caries effect as described in the first aspect, the method comprising stirring and mixing an anti-caries agent, a stain remover, a humectant, a foaming agent, a solvent, an optional thickener, an optional chelating agent, an optional viscosity modifier, and an optional taste improver, and then defoaming to obtain the toothpaste.

[0034] Preferably, the stirring speed is 500-1200 rpm.

[0035] Preferably, the mixing temperature is 20-30°C, and the mixing time is 20-40 minutes.

[0036] Specific values ​​for the 500-1200rpm range can be selected from 500rpm, 700rpm, 900rpm, 1100rpm, 1200rpm, etc.; specific values ​​for the 20-30℃ range can be selected from 20℃, 22℃, 24℃, 26℃, 28℃, 30℃, etc.; and specific values ​​for the 20-40min range can be selected from 20min, 22min, 24min, 26min, 28min, 30min, etc.

[0037] The numerical range described in this invention includes not only the point values ​​listed above, but also any point values ​​within the numerical ranges not listed above. Due to space limitations and for the sake of brevity, this invention will not exhaustively list all the specific point values ​​included in the range.

[0038] Compared with the prior art, the present invention has the following beneficial effects:

[0039] This invention provides a toothpaste with anti-caries effect, which can effectively remove Streptococcus mutans and has anti-caries effect, while also removing plaque and whitening effect.

[0040] This invention creatively discovers that hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide have a significant synergistic effect in removing Streptococcus mutans and preventing tooth decay, while also having a certain effect on removing tooth stains. Furthermore, controlling the mass ratio of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide within the range of (3-5):(1-3):(0.5-1) can better enhance the toothpaste's anti-caries effect.

[0041] Furthermore, this invention creatively discovers that the absence of any one of the following components—calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside—significantly reduces the overall stain removal effect of the toothpaste, indicating that calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside have a significant synergistic effect in removing tooth stains. Additionally, these components also possess a certain degree of ability to prevent the growth of Streptococcus mutans. Detailed Implementation

[0042] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0043] The sources of each component / raw material in the following embodiments are shown in Table 1.

[0044] Table 1

[0045]

[0046]

[0047] Example 1

[0048] This embodiment provides a toothpaste with anti-caries effect, which, based on 100 parts by weight, includes 8 parts of anti-caries agent, 3 parts of stain remover, 20 parts of moisturizer, 2 parts of foaming agent, 0.3 parts of thickener, 0.8 parts of chelating agent, 12 parts of viscosity modifier, 0.3 parts of taste improver, and the balance being water.

[0049] The caries-preventing agent consists of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide in a mass ratio of 4:2:0.7.

[0050] The spot-removing agent is composed of calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside in a mass ratio of 0.8:0.3:2.

[0051] The foaming agent is sodium lauryl gluconate, sodium citrate, and sorbic acid in a mass ratio of 3:0.6:0.1;

[0052] The thickener is a PVM / MA copolymer and lecithin in a mass ratio of 50:1;

[0053] The chelating agent is tetrasodium pyrophosphate;

[0054] The viscosity modifier is a mixture of hydrated silica, xanthan gum, and cellulose gum in a mass ratio of 16:0.2:0.8.

[0055] The taste improver is sodium saccharin.

[0056] The toothpaste is prepared by stirring the above raw materials at 1000 rpm for 30 minutes at 25°C until they are evenly mixed.

[0057] Example 2

[0058] This embodiment provides a toothpaste with anti-caries effect, which, based on 100 parts by weight, includes 6 parts of anti-caries agent, 2 parts of stain remover, 30 parts of moisturizer, 3 parts of foaming agent, 0.1 parts of thickener, 1 part of chelating agent, 10 parts of viscosity modifier, 0.5 parts of taste improver, and the balance being water.

[0059] The caries-preventing agent consists of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide in a mass ratio of 5:1:0.5.

[0060] The spot-removing agent is composed of calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside in a mass ratio of 1:0.1:1.

[0061] The foaming agent is sodium lauryl gluconate, sodium citrate, and sorbic acid in a mass ratio of 4:0.5:0.2;

[0062] The thickener is a PVM / MA copolymer and lecithin in a mass ratio of 45:2;

[0063] The chelating agent is tetrasodium pyrophosphate;

[0064] The viscosity modifier is a mixture of hydrated silica, xanthan gum, and cellulose gum in a mass ratio of 15:0.5:0.3.

[0065] The taste improver is sodium saccharin.

[0066] The toothpaste is prepared by stirring the above raw materials at 500 rpm for 40 minutes at 30°C until they are evenly mixed.

[0067] Example 3

[0068] This embodiment provides a toothpaste with anti-caries effect, which, based on 100 parts by weight, includes 5 parts of anti-caries agent, 1 part of stain remover, 10 parts of moisturizer, 0.5 parts of foaming agent, 0.5 parts of thickener, 0.5 parts of chelating agent, 15 parts of viscosity modifier, 0.1 parts of taste improver, and the balance being water.

[0069] The caries-preventing agent consists of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide in a mass ratio of 3:3:1.

[0070] The spot-removing agent is composed of calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside in a mass ratio of 0.5:0.5:5.

[0071] The foaming agent is sodium lauryl gluconate, sodium citrate, and sorbic acid in a mass ratio of 2:1:0.3;

[0072] The thickener is a PVM / MA copolymer and lecithin in a mass ratio of 60:1;

[0073] The chelating agent is tetrasodium pyrophosphate;

[0074] The viscosity modifier is hydrated silica, xanthan gum and cellulose gum in a mass ratio of 15:0.5:1;

[0075] The taste improver is sodium saccharin.

[0076] The toothpaste is prepared by stirring the above raw materials at 1200 rpm for 20 minutes at 20°C until they are evenly mixed.

[0077] Example 4

[0078] This embodiment provides a toothpaste with anti-caries effect. The only difference between this embodiment and Embodiment 1 is that the total mass fraction of the anti-caries agent remains unchanged, and the mass ratio of hydroxyapatite, sodium monofluorophosphate and casein phosphopeptide in the anti-caries agent is adjusted to 1:2:3. The rest of the formula and preparation method are the same as in Embodiment 1.

[0079] Example 5

[0080] This embodiment provides a toothpaste with anti-caries effect. The only difference between this embodiment and Embodiment 1 is that the total mass fraction of the anti-caries agent remains unchanged, and the mass ratio of hydroxyapatite, sodium monofluorophosphate and casein phosphopeptide in the anti-caries agent is adjusted to 6:0.5:2. The rest of the formula and preparation method are the same as in Embodiment 1.

[0081] Example 6

[0082] This embodiment provides a toothpaste with anti-caries effect. The only difference between this embodiment and Embodiment 1 is that the total mass fraction of the stain remover remains unchanged, and the stain remover is adjusted to be calcium glycerophosphate and sodium lauryl sulfate in a mass ratio of 0.8:0.3. The rest of the formula and preparation method are the same as in Embodiment 1.

[0083] Example 7

[0084] This embodiment provides a toothpaste with anti-caries effect. The only difference between this embodiment and Embodiment 1 is that the total mass fraction of the stain remover remains unchanged, and the stain remover is adjusted to be calcium glycerophosphate and lauryl glucoside in a mass ratio of 0.8:2. The rest of the formula and preparation method are the same as in Embodiment 1.

[0085] Example 8

[0086] This embodiment provides a toothpaste with anti-caries effect. The only difference between this embodiment and Embodiment 1 is that the total mass fraction of the stain remover remains unchanged, and the stain remover is adjusted to sodium lauryl sulfate and lauryl glucoside in a mass ratio of 0.3:2. The rest of the formula and preparation method are the same as in Embodiment 1.

[0087] Comparative Example 1

[0088] This comparative example provides a toothpaste with anti-caries effect. The only difference between this example and Example 1 is that the total mass fraction of the anti-caries agent remains unchanged, and the anti-caries agent is adjusted to a mass ratio of hydroxyapatite and sodium monofluorophosphate of 4:2. The rest of the formulation and preparation method are the same as in Example 1.

[0089] Comparative Example 2

[0090] This comparative example provides a toothpaste with anti-caries effect. The only difference between this toothpaste and Example 1 is that the total mass fraction of the anti-caries agent remains unchanged, and the anti-caries agent is adjusted to be hydroxyapatite and casein phosphopeptide in a mass ratio of 4:0.7. All other formulations and preparation methods are the same as in Example 1.

[0091] Comparative Example 3

[0092] This comparative example provides a toothpaste with anti-caries effect. The only difference between this toothpaste and Example 1 is that the total mass fraction of the anti-caries agent remains unchanged, and the anti-caries agent is adjusted to sodium monofluorophosphate and casein phosphopeptide in a mass ratio of 2:0.7. All other formulations and preparation methods are the same as in Example 1.

[0093] Test Example 1

[0094] Test on the inhibitory effect on cariogenic bacteria:

[0095] (1) Test principle:

[0096] Streptococcus mutans is a major cariogenic bacterium. Using Streptococcus mutans as the research subject, bovine tooth modules contaminated with Streptococcus mutans were brushed 50 times with a toothbrush coated with toothpaste. The number of residual colonies on the bovine tooth modules was collected. By comparing the number of colonies collected from bovine tooth modules that had not been brushed, the removal rate of Streptococcus mutans by the toothpaste was calculated.

[0097] (2) Test method:

[0098] (2.1) Preparation of Streptococcus mutans suspension: Streptococcus mutans CICC10387 was inoculated onto TSA agar plates and anaerobically cultured at 36℃±1℃ for 60 h. Typical colonies from the first generation culture were streaked onto TSA agar plates using an inoculation loop and anaerobically cultured at 36℃±1℃ for 60 h to obtain the second generation culture. Fresh colonies from the third generation were picked, mixed with PBS, and the bacterial concentration was adjusted to 10⁻⁶. 8 CFU / mL was used to prepare a suspension of Streptococcus mutans for later use.

[0099] (2.2) Simulation of Streptococcus mutans formation: The sterilized bovine tooth module was placed in a sterile bottle, and 10 mL of Streptococcus mutans suspension and 10 mL of BHI broth were added to each bottle. The mixture was then anaerobically cultured at 36℃±1℃ for 24 h.

[0100] (2.3) Experimental grouping and intervention method: The bovine teeth were divided into 12 groups with 6 teeth in each group. Groups 1-11 were the experimental groups, which were brushed with the toothpaste of Examples 1-8 and Comparative Examples 1-3 respectively. Group 13 was the control group, which did not brush its teeth.

[0101] In each experimental group, approximately 1g of toothpaste was applied to an unused toothbrush, which was then used to fix the cow teeth. The teeth were brushed 50 times back and forth for 7 consecutive days. The toothpaste foam was then rinsed off the surface of the cow teeth with sterile water. The cow teeth were then placed in a sterile homogenizing bag and each tooth was washed with 20mL of SCDLP. After anaerobic incubation at 36℃±1℃ for 60h, the teeth were counted, and the average value was recorded as A.

[0102] The control group consisted of untreated bovine teeth. The bovine teeth were placed in a sterile homogenizing bag, and each tooth was washed with 20 ml of LSCDLP. After anaerobic incubation at 36℃±1℃ for 60 h, the teeth were counted, and the average value was recorded as B.

[0103] Colony counts will be taken in the range of 30-300. For each sample, the colony count is calculated by multiplying the value read on the plate by the dilution factor.

[0104] Removal rate of Streptococcus mutans = (BA) / B × 100%.

[0105] (3) Test results:

[0106] The removal rate test results of Streptococcus mutans in each experimental group are shown in Table 2.

[0107] Table 2

[0108]

[0109]

[0110] As can be seen from the data in Table 2, the toothpaste of the present invention can effectively remove Streptococcus mutans, thereby effectively preventing tooth decay.

[0111] A comparison of the data from Example 1 and Comparative Examples 1-3 shows that the absence of any one of hydroxyapatite, sodium monofluorophosphate, or casein phosphopeptide significantly reduces the overall effectiveness of the toothpaste in removing Streptococcus mutans, indicating that hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide have a significant synergistic effect in removing Streptococcus mutans and preventing dental caries.

[0112] A comparison of the data from Examples 1 and 4-5 shows that controlling the mass ratio of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide within the range of (3-5):(1-3):(0.5-1) can better enhance the toothpaste's anti-caries effect.

[0113] A comparison of the data from Examples 1 and 6-8 shows that calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside all have the effect of preventing bacterial growth and also have a certain effect on removing Streptococcus mutans.

[0114] Test Example 2

[0115] Spot removal effect test:

[0116] (1) Samples to be tested: toothpaste prepared in Examples 1-8 and Comparative Examples 1-3.

[0117] (2) Testing process:

[0118] One hundred and ten volunteers aged 30-50 with extrinsic dental stains were randomly divided into 11 groups of 10 each. All volunteers were given the same soft-bristled toothbrush and brushed their teeth twice daily, morning and evening, for two minutes each time. Volunteers were instructed to maintain their usual oral hygiene habits, dietary habits, and smoking habits. Clinical examinations were conducted at the start of the test and at week eight, and were performed by the same examiner.

[0119] (3) Evaluation method:

[0120] Tooth stains are evaluated using the Lobene Stain Index, which uses a number from 0 to 3 to assess the size and severity of the stain.

[0121] The Lobene Pigmentation Index (LoBN) scoring table is shown in Table 3.

[0122] Table 3

[0123] Score Evaluation criteria 0 No pigmentation spots present 1 The stain does not exceed 1 / 3 of the tooth surface; mild staining (yellow or yellowish-brown) 2 The stain does not exceed 2 / 3 of the tooth surface; it is a moderate stain (medium-toned brown). 3 The stain covers more than 2 / 3 of the tooth surface; severe staining (dark brown or black)

[0124] (4) Test results:

[0125] The average Lobene stain index test results after volunteers used the toothpastes of each example and comparative example are shown in Table 4.

[0126] Table 4

[0127]

[0128]

[0129] As can be seen from the data in Table 4, the toothpaste of the present invention can effectively remove tooth stains and improve the whitening effect of teeth.

[0130] A comparison of the data from Examples 1 and 6-8 shows that the absence of any one of the following ingredients significantly reduces the overall stain removal effect of the toothpaste: calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside. This indicates that calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside have a significant synergistic effect in removing tooth stains.

[0131] A comparison of the data from Example 1 and Comparative Examples 1-3 shows that hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide have a certain effect on removing tooth stains while removing Streptococcus mutans.

[0132] The applicant declares that the technical solution of this invention is illustrated by the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of raw materials for the products of this invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of this invention.

[0133] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0134] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A toothpaste with anti-caries effect, characterized in that, The raw materials for preparing the toothpaste include anti-caries agents, stain removers, humectants, foaming agents, and solvents; The caries-preventing agent includes hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide.

2. The toothpaste according to claim 1, characterized in that, The raw materials for preparing the toothpaste, by weight, include 5-8 parts of anti-caries agent, 1-3 parts of stain remover, 10-30 parts of moisturizer, 0.5-3 parts of foaming agent, and 20-80 parts of solvent.

3. The toothpaste according to claim 1 or 2, characterized in that, The mass ratio of hydroxyapatite, sodium monofluorophosphate, and casein phosphopeptide is (3-5):(1-3):(0.5-1).

4. The toothpaste according to any one of claims 1-3, characterized in that, The spot-removing agent includes calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside; Preferably, the mass ratio of the calcium glycerophosphate, sodium lauryl sulfate, and lauryl glucoside is (0.5-1):(0.1-0.5):(1-5).

5. The toothpaste according to any one of claims 1-4, characterized in that, The moisturizer includes any one or a combination of at least two of sorbitol, xylitol or glycerin; Preferably, the foaming agent comprises any one or a combination of at least two of sodium lauryl glucocarboxylate, sodium citrate, or sorbic acid; Preferably, the solvent includes water.

6. The toothpaste according to any one of claims 1-5, characterized in that, The raw materials for preparing the toothpaste also include any one or a combination of at least two of the following: thickeners, chelating agents, viscosity modifiers, or taste improvers.

7. The toothpaste according to claim 6, characterized in that, The raw materials for preparing the toothpaste, by mass, also include any one or a combination of at least two of the following: 0.1-0.5 parts thickener, 0.5-1 parts chelating agent, 10-15 parts viscosity modifier, and 0.1-0.5 parts taste improver.

8. The toothpaste according to claim 6 or 7, characterized in that, The thickener includes methyl vinyl ether-maleic anhydride copolymer and / or lecithin; Preferably, the chelating agent comprises tetrasodium pyrophosphate; Preferably, the viscosity modifier comprises any one or a combination of at least two of hydrated silica, xanthan gum, or cellulose gum; Preferably, the taste improver includes sodium saccharin.

9. A method for preparing a toothpaste with anti-caries effect as described in any one of claims 1-8, characterized in that, The preparation method includes stirring and mixing an anti-caries agent, a spot remover, a humectant, a foaming agent, a solvent, an optional thickener, an optional chelating agent, an optional viscosity modifier, and an optional taste improver, followed by defoaming to obtain the final product.

10. The preparation method according to claim 9, characterized in that, The stirring speed is 500-1200 rpm; Preferably, the mixing temperature is 20-30°C, and the mixing time is 20-40 minutes.

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