A medicine pharmaceutical mixing and dispensing device and method thereof

Abstract

The application discloses a kind of medicine pharmaceutical mixed liquid preparation equipment and method thereof, it is related to mixing technical field, including mixing kettle, further including fixedly installed in the drive motor of mixing kettle external top and the stirring assembly installed in mixing kettle inside;The stirring assembly is composed of stirring rod and stirrer, the stirring rod is inclined design, the stirrer is installed at the end of stirring rod, and the stirring rod is fixedly connected with the drive end of drive motor by electric push rod.The advantages are that: the present application adopts inclined stirring mixing, not only improves mixing efficiency, but also reduces material loss, at the same time, kettle body and mixing rod are used to extract part of mixed liquid for further mixing, improve mixing efficiency, and the amount of liquid entering the kettle body at different depths of the mixing kettle can be changed according to the properties of each substance in the mixed liquid, so that the mixing of substances in the mixed liquid is more thorough.

Description

Technical Field

[0001] This invention relates to the field of mixing technology, and more particularly to a mixing and preparation device and method for pharmaceutical manufacturing. Background Technology

[0002] Wet granulation is a common method for producing granular drugs. Its core step is to mix drug powder with excipients, add liquid binder, and then agglomerate the powder into granules by stirring or shearing. The liquid binder is composed of a variety of different substances. The preparation of the liquid binder requires control of the content of each substance. Therefore, a liquid binder mixing device is needed to mix the various substances.

[0003] Traditional mixing equipment often suffers from uneven mixing and low mixing efficiency when preparing liquid adhesives, which can easily lead to unstable properties of the liquid adhesive. Therefore, CN106823962A discloses a vertical liquid mixing vibratory stirring device and a stirring method, which includes a base. The upper surface of the base is connected to a vibratory device by bolts. The vibratory device has a protruding plane in the middle, which is in contact with the bottom surface of the mixing drum. The upper end of the mixing drum is covered with a cover plate. The upper surface of the base is welded to a support frame on both sides. The mixing drum is installed inside the support frame. The upper surface of the support frame is connected to a reducer by bolts. The reducer is connected to a motor through a flange.

[0004] The aforementioned vibratory mixing device uses vibration to accelerate molecular motion, and in conjunction with two sets of opposing spiral blades, it causes the mixture to churn, preventing the mixture from flowing due to inertia during the mixing process. This effectively improves the mixing efficiency. However, in actual use, the bidirectional rotating spiral blades cause a large area of ​​the mixture to churn, which makes it difficult for the mixture to collide fully, resulting in a longer mixing time. At the same time, the opposing spiral blades cause the mixture to splash, causing some of the mixture to adhere to the top of the mixing equipment, resulting in some material loss and low mixing efficiency.

[0005] Therefore, a novel pharmaceutical mixing and preparation equipment and method can be adopted to overcome the shortcomings of existing technologies. Summary of the Invention

[0006] The purpose of this invention is to solve the problem of low mixing efficiency in the prior art, and to propose a pharmaceutical mixing and preparation device and method.

[0007] To achieve the above objectives, the present invention adopts the following technical solution:

[0008] A pharmaceutical mixing and dispensing device includes a mixing vessel, a drive motor fixedly mounted on the top of the mixing vessel, and a stirring assembly installed inside the mixing vessel.

[0009] The mixing assembly consists of a stirring rod and a stirrer. The stirring rod is designed to be inclined, and the stirrer is installed at the end of the stirring rod. The stirring rod is fixedly connected to the drive end of the drive motor through an electric push rod.

[0010] The agitator consists of a vessel body, which is fixedly connected to the agitator rod. A mixing rod is rotatably installed inside the vessel body, and a drive mechanism that cooperates with the mixing rod is installed on the vessel body. A liquid inlet mechanism and a liquid outlet mechanism are installed on the vessel body. The liquid inlet mechanism introduces liquid according to the depth of the agitator and forms a countercurrent in the vessel body by introducing liquid in different directions. A vibrating plate is fixedly installed at the bottom of the vessel body.

[0011] Preferably, the driving mechanism includes a vessel cover fixedly installed on the vessel body, a drain pipe fixedly installed on the vessel cover, a turbine fan rotatably installed inside the drain pipe, and multiple liquid outlet pipes fixedly connected to the bottom of the drain pipe, a flow guide shroud fixedly installed on the top of the drain pipe, a trapezoidal baffle fixedly installed at the top inside the flow guide shroud, a connecting shaft fixedly installed on the turbine fan, and a fixed connection between the connecting shaft and the mixing rod.

[0012] Preferably, a filter screen is fixedly installed at the top of the drainage tube, an elastic telescopic rod is fixedly installed on the turbine fan, a roller is fixedly installed on the rod, and a stop block that cooperates with the roller is fixedly installed inside the drainage tube.

[0013] Preferably, the liquid inlet mechanism includes multiple liquid guide pipes fixedly installed on the side of the vessel body. Each liquid guide pipe is connected to the vessel body, and each liquid guide pipe is fixedly connected to a liquid inlet pipe. A sealing structure that cooperates with the liquid guide pipe is installed on the liquid inlet pipe.

[0014] Preferably, the sealing structure includes a sealing ring that is slidably installed in the liquid inlet pipe, a driving component that cooperates with the sealing ring is installed on both the vessel body and the liquid inlet pipe, and an adjusting component that cooperates with the sealing ring is installed on the liquid inlet pipe.

[0015] Preferably, the driving component includes a segmented airbag ring fixedly installed outside the vessel body, multiple air guide pipes fixedly installed on the airbag ring, multiple first cylinders fixedly installed outside the vessel body, a liquid inlet pipe connected to the first cylinder, a second cylinder fixedly installed inside the first cylinder, a third piston disc slidably installed inside the second cylinder, a push rod fixedly installed on the third piston disc, a second piston disc slidably installed on the push rod, each air guide pipe connected to the corresponding second cylinder, a first piston disc slidably installed inside the liquid inlet pipe, and a locking component slidably installed on the liquid inlet pipe.

[0016] Preferably, the locking component includes a fixed ring fixedly installed inside the inlet pipe, a plurality of wedges fixedly installed on the fixed ring by means of an elastic telescopic rod, a slide rod fixedly installed on the first piston plate, a first wedge plate cooperating with the wedges fixedly installed at the end of the slide rod, and a second wedge plate cooperating with the wedges slidably installed on the slide rod, and a return spring fixedly installed between the second wedge plate and the slide rod.

[0017] Preferably, the adjusting component includes multiple linkage rods fixedly installed on the sealing ring, a friction ring fixedly installed on the multiple linkage rods, a bracket fixedly installed on the inlet pipe, a screw threadedly installed on the bracket, a disc rotatably installed at the bottom of the screw, a spring rod fixedly installed on the disc, a friction plate that mates with the friction ring fixedly installed on the spring rod, and a hole that mates with the friction plate opened on the inlet pipe.

[0018] Preferably, the liquid discharge mechanism includes a sealing plate fixedly installed at the bottom of the vessel body. The upper surface of the sealing plate is concave, and a liquid discharge hole is opened in the middle of the sealing plate. A drain pipe connected to the liquid discharge hole is fixedly installed at the bottom of the sealing plate, and the drain pipe passes through and extends out of the vessel body.

[0019] The present invention also provides a method for mixing and preparing pharmaceutical solutions, for use in the aforementioned pharmaceutical mixing and preparation equipment, comprising the following steps:

[0020] S1. First, add each substance into the mixing vessel, then start the drive motor. The drive end of the drive motor rotates, which drives the stirring rod to rotate, and then drives the stirrer to rotate, so as to stir and mix the mixture in the mixing vessel.

[0021] S2. As the mixing process proceeds, the liquid in the mixing vessel will enter the vessel body through the liquid inlet mechanism. Then, the mixing rod inside the vessel body will mix the liquid in the vessel body again after it has been stirred and mixed. The liquid inlet mechanism controls the liquid inlet according to the different depth positions reached by the stirrer, which can avoid the stratification phenomenon.

[0022] S3. After two mixing processes, the mixture is discharged from the vessel body through the liquid outlet mechanism and enters the mixing vessel. When the vessel body rotates, the vibration plate and the mixture will impact each other, causing the vibration plate to vibrate. The vibration is used to accelerate the movement of the mixture molecules and improve the mixing efficiency.

[0023] Compared with existing technologies, the advantages of this invention are:

[0024] 1. When preparing liquid binders, this pharmaceutical mixing equipment uses an inclined stirring rod and a stirrer to stir and mix the liquid in the mixing vessel. This effectively avoids splashing of the liquid during stirring and reduces the probability of loss of some substances in the liquid. At the same time, the inclined stirring rod can not only stir in the horizontal direction, but also replace the liquid in the vertical direction, making the mixing more thorough and the mixing efficiency higher.

[0025] 2. In the preparation of liquid binders, the mixing and dispensing equipment for pharmaceutical manufacturing uses an air bladder ring to inject air into the second cylinder. Then, the first cylinder drives the sealing plate to move. The air bladder ring can change the air intake in the second cylinder according to the depth of the stirrer immersed in the mixture, thereby changing the suction force of the first cylinder on the first piston plate. This achieves the purpose of different liquid intake at different depths, which can bring as much of the material at the bottom as possible to the top of the mixture, thus improving the mixing efficiency.

[0026] 3. In the preparation of liquid binders, the mixing and dispensing equipment for pharmaceutical manufacturing uses a wedge block, a first wedge disk, and a second wedge disk to achieve intermittent operation of the first piston disk. The first piston disk opens the sealing disk in the first operation, and the sealing disk remains open, ensuring the same liquid intake at different depths. The second operation moves the sealing disk, at which point the electric actuator changes the depth of the air bladder ring, resulting in a larger displacement of the first piston disk. Under the action of the second wedge disk, the first piston disk resets. After resetting, the position of the first piston disk changes with the depth of the air bladder ring, resulting in different intake volumes of the mixture at different depths. This intermittent liquid intake operation creates different counter-current effects, improving mixing efficiency and ensuring more thorough mixing.

[0027] 4. In the preparation of liquid binders, the mixing and dispensing equipment for pharmaceutical manufacturing uses a screw to adjust the pressure between the friction plate and the friction ring. During mixing, the pressure required for the friction ring to move changes, thereby changing the opening degree of the liquid guide tube to achieve multi-mode liquid injection. The mode can be selected according to the needs. The smaller the opening of the liquid guide tube, the more thorough the mixing, which is suitable for mixing substances with low diffusion properties. The larger the opening of the liquid guide tube, the faster the mixing speed, which is suitable for mixing substances with high diffusion properties.

[0028] In summary, this invention employs an inclined stirring and mixing method, which not only improves mixing efficiency but also reduces material loss. Furthermore, the use of a vessel and mixing rod to partially extract and further mix the mixture improves mixing efficiency. Moreover, the amount of liquid entering the vessel at different depths can be adjusted according to the properties of the substances in the mixture, resulting in more thorough mixing of the substances in the mixture. Attached Figure Description

[0029] The specific embodiments of the present invention will be further described in detail below with reference to the accompanying drawings, wherein:

[0030] Figure 1 This is a schematic diagram of the structure of a pharmaceutical mixing and preparation device proposed in this invention;

[0031] Figure 2 for Figure 1 Detailed schematic diagram of the planar structure after removing the mixing vessel;

[0032] Figure 3 for Figure 2 Detailed schematic diagram of the structure after rotation at a certain angle;

[0033] Figure 4 for Figure 3 Detailed schematic diagram of the enlarged structure of the stirrer;

[0034] Figure 5 for Figure 4 Detailed schematic diagram of the structure after removing the sleeve and protective cover;

[0035] Figure 6 for Figure 5 Detailed schematic diagram of the planar structure along one of the angles;

[0036] Figure 7 for Figure 6 Detailed schematic diagram of the planar structure along section AA;

[0037] Figure 8 for Figure 6 Detailed schematic diagram of the three-dimensional structure along section AA;

[0038] Figure 9 for Figure 8 Detailed schematic diagram of the planar structure of the central drainage tube, mixing rod, and outlet tube along one of the angles;

[0039] Figure 10 for Figure 9 Detailed schematic diagram of the planar structure along section BB;

[0040] Figure 11 for Figure 9 Detailed schematic diagram of the three-dimensional structure along the BB section;

[0041] Figure 12 for Figure 11 Enlarged schematic diagram of components such as the central drainage tube, turbine fan, and filter screen;

[0042] Figure 13 for Figure 8 Detailed schematic diagram of the structure of the central liquid inlet pipe, airbag ring and first cylinder;

[0043] Figure 14 for Figure 13 Detailed schematic diagram of the planar structure of the central liquid inlet pipe and the first cylinder along one of the angles;

[0044] Figure 15 for Figure 14 Detailed schematic diagram of the planar structure along the CC section;

[0045] Figure 16 for Figure 14 Detailed schematic diagram of the three-dimensional structure along the CC section;

[0046] Figure 17 for Figure 16 Enlarged schematic diagram of components such as the inlet pipe, guide pipe, friction ring, and support;

[0047] Figure 18 for Figure 17 Enlarged schematic diagram of the first piston disc, the retaining ring, and their surrounding components;

[0048] Figure 19 for Figure 17 Enlarged structural schematic diagram of the central support and its surrounding components;

[0049] Figure 20 for Figure 17 Detailed diagram of the decomposed structure;

[0050] Figure 21 for Figure 16 Detailed schematic diagram of the first cylinder block and the air guide pipe along one of the angles;

[0051] Figure 22 for Figure 21 Detailed schematic diagram of the planar structure along the DD section;

[0052] Figure 23 for Figure 21 Detailed schematic diagram of the three-dimensional structure along the DD section.

[0053] In the diagram: 1 Mixing vessel, 2 Drive motor, 3 Stirring rod, 4 Stirrer, 5 Flow guide, 6 Vessel body, 7 Vibrating plate, 8 Drain pipe, 9 Airbag ring, 10 Protective cover, 11 Vessel lid, 12 Drain pipe, 13 Inlet pipe, 14 First cylinder body, 15 Sealing plate, 16 Mixing rod, 17 Outlet pipe, 18 Filter screen, 19 Turbine fan, 20 Outer cover, 21 Air guide pipe, 22 Friction ring, 23 Support, 24 First piston plate, 25 Fixing ring, 26 Wedge block, 27 First wedge plate, 28 Second wedge plate, 29 Friction plate, 30 Screw, 31 Spring rod, 32 Second cylinder body, 33 Second piston plate, 34 Push rod, 35 Third piston plate, 36 Liquid guide pipe, 37 Connecting rod. Detailed Implementation

[0054] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0055] Example 1: Refer to Figures 1-3 A pharmaceutical mixing and dispensing device includes a mixing vessel 1, a drive motor 2 fixedly installed on the top of the outside of the mixing vessel 1, and a stirring assembly installed inside the mixing vessel 1.

[0056] The stirring assembly consists of a stirring rod 3 and a stirrer 4. The stirring rod 3 is designed to be inclined, and the stirrer 4 is installed at the end of the stirring rod 3. The stirring rod 3 is fixedly connected to the drive end of the drive motor 2 through an electric push rod.

[0057] The drive motor 2 rotates, causing the electric push rod fixedly connected to it to rotate. The rotation of the electric push rod causes the stirring rod 3 fixedly connected to it to rotate, thereby driving the stirrer 4 to rotate. The mixture in the mixing vessel 1 is stirred and mixed by the rotation of the stirring rod 3 and the stirrer 4.

[0058] The inclined stirring rod 3 and the stirrer 4 are used to stir and mix the mixture in the mixing vessel 1, which can effectively prevent the mixture from splashing during the stirring process and reduce the probability of some substances being lost. At the same time, the inclined stirring rod 3 can not only stir in the horizontal direction, but also replace the mixture in the vertical direction, making the mixing more thorough and the mixing efficiency higher.

[0059] Example 2: This example differs from Example 1 in that: (Refer to...) Figures 4-12 The stirrer 4 is composed of a vessel body 6, and the vessel body 6 is fixedly connected to the stirring rod 3. A mixing rod 16 is rotatably installed inside the vessel body 6, and a drive mechanism that cooperates with the mixing rod 16 is installed on the vessel body 6.

[0060] The driving mechanism includes a vessel cover 11 fixedly installed on the vessel body 6, a drainage pipe 12 fixedly installed on the vessel cover 11, a turbine fan 19 rotatably installed inside the drainage pipe 12, and multiple liquid outlet pipes 17 fixedly connected to the bottom of the drainage pipe 12. A flow guide shroud 5 is fixedly installed on the top of the drainage pipe 12, and a trapezoidal baffle block is fixedly installed inside the top of the flow guide shroud 5. A connecting shaft is fixedly installed on the turbine fan 19, and the connecting shaft is fixedly connected to the mixing rod 16.

[0061] The drainage tube 12 is externally fixedly fitted with a sleeve that mates with multiple outlet tubes 17. This sleeve protects the outlet tubes 17 and reduces resistance to the mixture, effectively preventing splashing of the mixture.

[0062] As the stirrer 4 rotates, the mixture in the mixing vessel 1 impacts the guide shroud 5 on the guide pipe 12 and enters the guide shroud 5. Under the action of the baffle block in the guide shroud 5, the mixture in the guide shroud 5 enters the guide pipe 12 and is then discharged through the outlet pipe 17 (this involves a pressure difference, so the speed of the stirrer 4 needs to be changed so that the impact force of the mixture entering the guide pipe 12 from the guide shroud 5 is greater than the water pressure at the end of the outlet pipe 17, so that the mixture can pass through the guide pipe 12). When the mixture passes through the guide pipe 12, it will drive the turbine fan 19 to rotate, thereby driving the mixing rod 16 to rotate, mixing the mixture in the vessel 6.

[0063] A filter screen 18 is fixedly installed at the top of the drainage pipe 12, and an elastic telescopic rod is fixedly installed on the turbine fan 19. A roller is fixedly installed on the rod, and a stop block that cooperates with the roller is fixedly installed inside the drainage pipe 12.

[0064] Before entering the diversion tube 12 from inside the flow guide shroud 5, the mixture is filtered through the filter screen 18, which isolates some particulate matter (liquid adhesives need to add some soluble particulate matter). As the turbine fan 19 rotates, it drives the elastic telescopic rods and rollers to rotate. When the rollers abut against the block, the rollers separate from the filter screen 18. After the rollers separate from the block, the rods cause the rollers to impact the filter screen 18, shaking off the particles adhering to the filter screen 18 and preventing the filter screen 18 from becoming clogged.

[0065] Example 3: This example differs from Example 2 in that: (Refer to...) Figures 4-23 The vessel body 6 is equipped with a liquid inlet mechanism and a liquid outlet mechanism. The liquid inlet mechanism feeds liquid according to the depth of the stirrer 4 and forms a counter-current in the vessel body 6 by feeding liquid in different directions. A vibrating plate 7 is fixedly installed at the bottom of the vessel body 6.

[0066] When the vessel body 6 rotates, the vibration plate 7 will impact the mixture, causing the vibration plate 7 to vibrate. The vibration will accelerate the movement of the mixture molecules and improve the mixing efficiency.

[0067] The liquid inlet mechanism includes multiple liquid guide pipes 36 fixedly installed on the side of the vessel body 6. Each liquid guide pipe 36 is connected to the vessel body 6. Each liquid guide pipe 36 is fixedly connected to a liquid inlet pipe 13. A sealing structure that cooperates with the liquid guide pipe 36 is installed on the liquid inlet pipe 13.

[0068] As the vessel body 6 rotates, the mixture in the mixing vessel 1 will enter the inlet pipe 13. When the sealing structure is closed, the mixture will not enter the vessel body 6 through the guide pipe 36. At this time, it is simply stirred and mixed in the mixing vessel 1. When the sealing structure is opened, the mixture will enter the vessel body 6 through the guide pipe 36, and then the mixture in the vessel body 6 will be stirred by the mixing rod 16.

[0069] The sealing structure includes a sealing ring that is slidably installed in the liquid inlet pipe 13, and a driving component that cooperates with the sealing ring is installed on both the vessel body 6 and the liquid inlet pipe 13;

[0070] The sealing ring will move under the action of the driving component. After the sealing ring moves, the mixed liquid in the liquid inlet pipe 13 will enter the vessel body 6 through the liquid guide pipe 36.

[0071] The driving components include a segmented airbag ring 9 fixedly installed on the outside of the vessel body 6. Multiple air guide pipes 21 are fixedly installed on the airbag ring 9 (each air guide pipe 21 is connected to a corresponding chamber of the segmented airbag ring 9, and the gas in each chamber can only enter the second cylinder 32 through the corresponding air guide pipe 21). Multiple first cylinders 14 are fixedly installed on the outside of the vessel body 6. The liquid inlet pipe 13 is connected to the first cylinder 14. The second cylinder 32 is fixedly installed inside the first cylinder 14. The third piston disc 35 that cooperates with the second cylinder 32 is slidably installed inside the second cylinder 32. The third piston disc 35 is fixedly installed on the third piston disc 35. The push rod 34 is fixedly installed on the push rod 34. The second piston disc 33 that cooperates with the first cylinder 14 is fixedly installed on the push rod 34. Each air guide pipe 21 is connected to the corresponding second cylinder 32. The first piston disc 24 that cooperates with the liquid inlet pipe 13 is slidably installed inside the liquid inlet pipe 13. The locking component that cooperates with the first piston disc 24 is installed on the liquid inlet pipe 13.

[0072] After the gas in the airbag ring 9 enters the second cylinder 32, it will push the third piston disc 35 to move. The push rod 34 will drive the second piston disc 33 to move, which will reduce the pressure on the side of the first cylinder 14 connected to the liquid inlet pipe 13. This will cause the first piston disc 24 to move closer to the first cylinder 14. The movement of the first piston disc 24 will drive the sealing ring to move, thereby opening the liquid guide pipe 36. After the liquid guide pipe 36 is opened, the mixture will enter the vessel 6 through the liquid guide pipe 36.

[0073] Because of the inclined design of the agitator 4, the depth of the air bladder ring 9 is different when the agitator 4 rotates. The depth of the air bladder ring 9 changes with each rotation, resulting in different compression of the air bladder ring 9 at different depths. This leads to different amounts of gas entering the second cylinder 32 from the air bladder ring 9, different displacement of the third piston disc 35 in the second cylinder 32, different displacement of the first piston disc 24, different opening degree of the liquid guide tube 36, and different amounts of mixture entering.

[0074] The locking component includes a fixed ring 25 fixedly installed inside the liquid inlet pipe 13. Multiple wedges 26 are fixedly installed on the fixed ring 25 via an elastic telescopic rod. A sliding rod is fixedly installed on the first piston disc 24. A first wedge disc 27 that cooperates with the wedges 26 is fixedly installed at the end of the sliding rod. A second wedge disc 28 that cooperates with the wedges 26 is slidably installed on the sliding rod. A return spring is fixedly installed between the second wedge disc 28 and the sliding rod.

[0075] When the first piston disc 24 moves for the first time, it drives the sealing ring to move, causing the liquid guide tube 36 to open. When the airbag ring 9 moves to the bottom, the airbag ring 9 is subjected to the greatest hydraulic pressure, and the displacement of the first piston disc 24 is the greatest. This will cause the first wedge disc 27 to move through the wedge block 26. Then the airbag ring 9 continues to rotate and the depth gradually becomes shallower. At this time, the wedge block 26 will lock the first wedge disc 27 to prevent the first wedge disc 27 from resetting. At this time, the liquid guide tube 36 is always in the open state, and the amount of mixed liquid entering the vessel body 6 at different depths is the same.

[0076] After the airbag ring 9 rotates once with the stirring rod 3, the electric actuator is activated to lower the depth of the lowest point of the airbag ring 9. When the airbag ring 9 reaches its lowest point for the second time, the hydraulic pressure on the airbag ring 9 is greater than the hydraulic pressure when it first reaches the bottom. Therefore, the displacement of the first piston disc 24 is greater than the displacement of the first piston disc 24 the first time, causing the second wedge disc 28 to pass through the wedge block 26. Figure 18 It is found that the first wedge plate 27 and the second wedge plate 28 are convex in shape and the trapezoidal directions are opposite. When the second wedge plate 28 passes through the wedge block 26 and the air bag ring 9 rises, the air pressure in the first cylinder 14 increases, pushing the first piston plate 24 to reset. At this time, the wedge block 26 will drive the second wedge plate 28 to move closer to the first wedge plate 27 until the second wedge plate 28 is in contact with the first wedge plate 27. Then the first piston plate 24 continues to reset, and the wedge block 26 will slide directly along the surface of the first wedge plate 27 and the second wedge plate 28 until the wedge block 26 separates from the first wedge plate 27. At this time, the sealing ring resumes the sealing of the liquid guide tube 36. At this time, the displacement of the first piston plate 24 is different at different depths, and the amount of mixed liquid entering the vessel 6 at different depths is different, realizing intermittent liquid injection.

[0077] The mixing vessel 1 is fixedly installed with a protective cover 10 that matches the first cylinder 14 to protect the first cylinder 14.

[0078] An adjusting component that mates with the sealing ring is installed on the inlet pipe 13;

[0079] The adjusting component includes multiple linkage rods 37 fixedly installed on the sealing ring, a friction ring 22 fixedly installed on the multiple linkage rods 37, a bracket 23 fixedly installed on the liquid inlet pipe 13, a screw 30 threadedly installed on the bracket 23, a disc rotatably installed at the bottom of the screw 30, a spring rod 31 fixedly installed on the disc, a friction plate 29 that mates with the friction ring 22 fixedly installed on the spring rod 31, and a hole that mates with the friction plate 29 is opened on the liquid inlet pipe 13;

[0080] The above-described liquid inlet pattern is based on the condition that the friction ring 22 and the friction plate 29 are separated. If the friction ring 22 and the friction plate 29 are in contact, the process will proceed through two other states:

[0081] The first method involves rotating the screw 30 to adjust the elastic force of the spring rod 31, thereby controlling the friction between the friction ring 22 and the friction plate 29. This changes the suction required for the first piston disc 24 to move, thus controlling the displacement of the sealing ring under the same suction force of the first cylinder 14, and adjusting it according to different diffusion properties.

[0082] The second method involves adjusting the friction between the friction ring 22 and the friction plate 29 to make the friction greater than the suction force of the first cylinder 14 on the first piston disc 24. In this case, the first piston disc 24 will not move, thus achieving the purpose of the sealing ring always sealing the liquid guide tube 36. At the same time, the position of the first piston disc 24 can be manually adjusted before mixing, and the first piston disc 24 can be locked by the friction plate 29 and the friction ring 22 to keep the sealing ring stationary. In this case, the liquid guide tube 36 is always in an open state, thus achieving the same liquid intake.

[0083] The liquid discharge mechanism includes a sealing plate 15 fixedly installed at the bottom of the inside of the vessel body 6. The upper surface of the sealing plate 15 is concave. A liquid discharge hole is opened in the middle of the sealing plate 15. A drain pipe 8 connected to the liquid discharge hole is fixedly installed at the bottom of the sealing plate 15. The drain pipe 8 passes through and extends out of the vessel body 6.

[0084] After the mixture is mixed in the vessel 6, it will enter the drain pipe 8 through the liquid outlet on the sealing plate 15, and then the mixed mixture will be discharged into the mixing vessel 1 through the drain pipe 8.

[0085] The specific operating steps of this device are as follows:

[0086] First, add each substance into the mixing vessel 1, then start the drive motor 2. The drive end of the drive motor 2 rotates, which drives the electric push rod fixedly connected to it to rotate. The rotation of the electric push rod drives the stirring rod 3 fixedly connected to it to rotate, thereby driving the stirrer 4 to rotate.

[0087] As the stirrer 4 rotates, the mixture in the mixing vessel 1 impacts the guide shroud 5 on the guide pipe 12 and enters the guide shroud 5. Under the action of the baffle block in the guide shroud 5, the mixture in the guide shroud 5 will enter the guide pipe 12 and then be discharged through the outlet pipe 17. When the mixture passes through the guide pipe 12, it will drive the turbine fan 19 to rotate, thereby driving the mixing rod 16 to rotate and mix the mixture in the vessel body 6.

[0088] As the vessel body 6 rotates, the depth of the airbag ring 9 changes. After the gas in the airbag ring 9 enters the second cylinder 32, it will push the third piston disc 35 to move. Through the push rod 34, it will drive the second piston disc 33 to move, which will reduce the pressure on the side of the first cylinder 14 connected to the liquid inlet pipe 13. This will cause the first piston disc 24 to move closer to the first cylinder 14. The movement of the first piston disc 24 will drive the sealing ring to move, thereby opening the liquid guide pipe 36. After the liquid guide pipe 36 is opened, the mixture will enter the vessel body 6 through the liquid guide pipe 36.

[0089] Because of the inclined design of the agitator 4, the depth of the air bladder ring 9 is different when the agitator 4 rotates. The depth of the air bladder ring 9 changes with each rotation, resulting in different compression of the air bladder ring 9 at different depths. This leads to different amounts of gas entering the second cylinder 32 from the air bladder ring 9, different displacement of the third piston disc 35 in the second cylinder 32, different displacement of the first piston disc 24, different opening degree of the liquid guide tube 36, and different amounts of mixture entering.

[0090] When the first piston disc 24 moves for the first time, it drives the sealing ring to move, causing the liquid guide tube 36 to open. When the airbag ring 9 moves to the bottom, the airbag ring 9 is subjected to the greatest hydraulic pressure, and the displacement of the first piston disc 24 is the greatest. This will cause the first wedge disc 27 to move through the wedge block 26. Then the airbag ring 9 continues to rotate and the depth gradually becomes shallower. At this time, the wedge block 26 will lock the first wedge disc 27 to prevent the first wedge disc 27 from resetting. At this time, the liquid guide tube 36 is always in the open state, and the amount of mixed liquid entering the vessel body 6 at different depths is the same.

[0091] After the airbag ring 9 rotates once with the stirring rod 3, the electric actuator is activated to lower the depth of the lowest point of the airbag ring 9. When the airbag ring 9 reaches its lowest point for the second time, the hydraulic pressure on the airbag ring 9 is greater than the hydraulic pressure when it first reaches the bottom. Therefore, the displacement of the first piston disc 24 is greater than the displacement of the first piston disc 24 the first time, causing the second wedge disc 28 to pass through the wedge block 26. Figure 18 It is found that the first wedge plate 27 and the second wedge plate 28 are convex in shape and the trapezoidal directions are opposite. When the second wedge plate 28 passes through the wedge block 26 and the air bag ring 9 rises, the air pressure in the first cylinder 14 increases, pushing the first piston plate 24 to reset. At this time, the wedge block 26 will drive the second wedge plate 28 to move closer to the first wedge plate 27 until the second wedge plate 28 is in contact with the first wedge plate 27. Then the first piston plate 24 continues to reset, and the wedge block 26 will slide directly along the surface of the first wedge plate 27 and the second wedge plate 28 until the wedge block 26 separates from the first wedge plate 27. At this time, the sealing ring resumes the sealing of the liquid guide tube 36. At this time, the displacement of the first piston plate 24 is different at different depths, and the amount of mixed liquid entering the vessel 6 at different depths is different, realizing intermittent liquid injection.

[0092] After the mixture is mixed in the vessel 6, it will enter the drain pipe 8 through the outlet hole on the sealing plate 15, and then the mixed mixture will be discharged into the mixing vessel 1 through the drain pipe 8.

[0093] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A pharmaceutical compounding device for mixing and dispensing a liquid, comprising a mixing tank, characterized in that, Also include fixedly installed in the mixing kettle outside the top drive motor and installed in the mixing kettle inside the stirring assembly; The stirring assembly is composed of a stirring rod and a stirrer, the stirring rod is designed to be inclined, the stirrer is installed at the end of the stirring rod, and the stirring rod is fixedly connected with the driving end of the driving motor through an electric push rod; The stirrer is composed of a kettle body, and the kettle body is fixedly connected with the stirring rod, a mixing rod is rotatably installed in the kettle body, a driving mechanism cooperating with the mixing rod is installed on the kettle body, a liquid inlet mechanism and a liquid outlet mechanism are installed on the kettle body, the liquid inlet mechanism inlet according to the depth of the stirrer, and the liquid inlet mechanism inlet in different directions to form a counterattack in the kettle body, and a vibrating plate is fixedly installed at the bottom of the kettle body; The liquid inlet mechanism includes a plurality of liquid guide pipes fixedly installed on the side of the kettle body, each liquid guide pipe is in communication with the kettle body, and a liquid inlet pipe is fixedly and communicatively connected to each liquid guide pipe, and a plugging structure cooperating with the liquid guide pipe is installed on the liquid inlet pipe; The plugging structure includes a plugging ring slidably installed in the liquid inlet pipe, a driving part cooperating with the plugging ring is jointly installed on the kettle body and the liquid inlet pipe, and an adjusting part cooperating with the plugging ring is installed on the liquid inlet pipe; The driving part includes a segmented air bag ring fixedly installed outside the kettle body, a plurality of air guide pipes are fixedly installed on the air bag ring, a plurality of first cylinders are fixedly installed outside the kettle body, the liquid inlet pipe is in communication with the first cylinder, a second cylinder is fixedly installed in the first cylinder, a third piston disc cooperating with the second cylinder is slidably installed in the second cylinder, a push rod is fixedly installed on the third piston disc, a second piston disc cooperating with the first cylinder is fixedly installed on the push rod, each air guide pipe is in communication with the corresponding second cylinder, a first piston disc cooperating with the liquid inlet pipe is slidably installed in the liquid inlet pipe, and a locking member cooperating with the first piston disc is installed on the liquid inlet pipe.

2. The pharmaceutical compounding device according to claim 1, wherein The driving mechanism includes a kettle cover fixedly installed on the kettle body, a drainage pipe is fixedly installed on the kettle cover, a turbofan is rotatably installed in the drainage pipe, a plurality of liquid outlet pipes are fixedly and communicatively connected to the bottom of the drainage pipe, a flow guide cover is fixedly installed at the top of the drainage pipe, a trapezoidal flow blocking block is fixedly installed at the top of the flow guide cover inside, a connecting shaft is fixedly installed on the turbofan, and the connecting shaft is fixedly connected with the mixing rod.

3. The pharmaceutical compounding device according to claim 2, wherein A filter screen is fixedly installed at the top of the drainage pipe, an elastic telescopic rod is fixedly installed on the turbofan, a roller is fixedly installed on the elastic telescopic rod, and a stop block cooperating with the roller is fixedly installed in the drainage pipe.

4. The pharmaceutical compounding device according to claim 1, wherein The locking member includes a fixed ring fixedly installed inside the liquid inlet pipe, a plurality of wedge blocks are fixedly installed on the fixed ring through elastic telescopic rods, a sliding rod is fixedly installed on the first piston disc, a first wedge disc cooperating with the wedge blocks is fixedly installed at the end of the sliding rod, a second wedge disc cooperating with the wedge blocks is slidably installed on the sliding rod, and a return spring is fixedly installed between the second wedge disc and the sliding rod.

5. The pharmaceutical compounding device according to claim 1, wherein The adjusting part includes a plurality of connecting rods fixedly installed on the plugging ring, a friction ring is jointly fixedly installed on the plurality of connecting rods, a support is fixedly installed on the liquid inlet pipe, a screw rod is threadedly and rotatably installed on the support, a disc is rotatably installed at the bottom of the screw rod, a spring rod is fixedly installed on the disc, a friction plate cooperating with the friction ring is fixedly installed on the spring rod, and a hole hole cooperating with the friction plate is formed in the liquid inlet pipe.

6. The pharmaceutical compounding device according to claim 1, wherein The liquid outlet mechanism comprises a blocking disc fixedly installed at the bottom inside the kettle body, the upper surface of the blocking disc is concave, a liquid outlet hole is formed at the middle position of the blocking disc, and a liquid discharge pipe communicated with the liquid outlet hole is fixedly installed at the bottom of the blocking disc and penetrates through and extends out of the kettle body.

7. A method of mixing and dispensing a pharmaceutical solution for use in a pharmaceutical mixing and dispensing apparatus as claimed in any one of claims 1 to 6, wherein The method comprises the following steps: S1, first, each substance is added into the mixing kettle, then the driving motor is started, the driving end of the driving motor rotates to drive the stirring rod to rotate, then the stirrer is driven to rotate, and the mixed liquid in the mixing kettle is stirred and mixed; S2, as the stirring and mixing proceed, the mixed liquid in the mixing kettle enters the kettle body through the liquid inlet mechanism, then the mixed liquid stirred and mixed in the kettle body is mixed again by the mixing rod in the kettle body, the liquid inlet mechanism controls the liquid inlet according to different depth positions of the stirrer, and stratification can be avoided; S3, after two times of mixing, the mixed liquid is finally discharged from the kettle body through the liquid outlet mechanism, enters the mixing kettle, and when the kettle body rotates, the vibration piece is impacted by the mixed liquid to vibrate, the vibration is used to accelerate the movement of the mixed liquid molecules, and the mixing efficiency is improved.

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