Neutron beam generation system for neutron capture therapy

Abstract

The invention discloses a neutron beam generation system for neutron capture therapy. According to one embodiment of the present disclosure, there is provided a neutron beam generation system, comprising: an incident device for generating a proton beam; the RF linear accelerator is connected with the incident device so as to accelerate the proton beam; a beam line transmitting the proton beam accelerated by the RF linear accelerator; a target material which collides with the proton beam transmitted by the beam line and generates fast neutrons; and a deceleration means disposed on one side of the bunch and configured to decelerate the fast neutrons to epithermal neutrons.

Description

Technical Field

[0001] This disclosure relates to a neutron beam generation system for neutron capture therapy. Background Technology

[0002] The content described in this section is only to provide background information for this disclosure and does not constitute prior art.

[0003] Neutron Capture Therapy (NCT) is a method of treating cancer by injecting boron, a component that effectively captures or absorbs neutrons, into cancer cells in the body and irradiating the cancer cells with neutrons. The powerful energy generated by the nuclear reaction between boron and neutrons induces the death of cancer cells.

[0004] Neutron capture therapy requires a device or system to generate and irradiate neutrons. There are two main methods for generating neutrons with an energy spectrum suitable for cancer treatment. The first method utilizes uranium nuclear fission in a nuclear reactor to generate neutrons. Although several countries have conducted research on generating neutrons through uranium nuclear fission, issues such as nuclear energy licensing make it unsuitable for hospital facilities used in patient treatment. The second method involves accelerating protons to bombard a target made of materials such as lithium or beryllium to generate neutrons. The method of using a proton accelerator to bombard a target to generate neutrons is also suitable for hospital facilities used in patient treatment, and research on this method is currently underway globally.

[0005] For a device that generates neutrons by accelerating protons and impacting a target to be used as a hospital facility, it needs to be free from radiation hazards and capable of continuously supplying 1×10⁻⁶ neutrons for more than one hour. 9 pcs / cm 2 • Epithermal neutrons above sec. Related to this, there are problems such as energy loss during proton beam acceleration, shielding required for radiation generation, excessive device size, device malfunctions due to handling high-energy protons and neutrons, long-term usable targets, and low treatment efficiency due to target replacement time. Summary of the Invention

[0006] Technical issues One embodiment of the neutron beam generation system includes an RF linear accelerator composed of low-energy and high-energy accelerating tubes, thereby enabling continuous generation of 1×10⁻⁶ neutron beams while maintaining a compact size. 9 pcs / cm 2 High-quality hyperthermal neutrons with a sec or higher.

[0007] One embodiment of the neutron beam generation system includes a beam direction adjustment unit composed of a bending magnet or the like, thereby enabling efficient treatment of patients using multiple beamlines and multiple targets.

[0008] The problems to be solved by the present invention are not limited to those mentioned above. Those skilled in the art will clearly understand other problems not mentioned from the following description.

[0009] Technical solution According to one embodiment of this disclosure, a neutron beam generating system is provided, comprising: an incident device that generates a proton beam; an RF linear accelerator connected to the incident device to accelerate the proton beam; a beamline that transmits the proton beam accelerated by the RF linear accelerator; a target that collides with the proton beam transmitted by the beamline to generate fast neutrons; and a deceleration assembly disposed on one side of the beamline and configured to decelerate the fast neutrons into hyperthermal neutrons.

[0010] Invention Effects According to one embodiment, the following effect is achieved: the neutron beam generation system includes an RF linear accelerator composed of low-energy and high-energy accelerating tubes, thereby enabling the continuous generation of 1×10⁻⁶ neutron beams while maintaining a compact size. 9 pcs / cm 2 High-quality hyperthermal neutrons with a sec or higher.

[0011] According to one embodiment, the neutron beam generation system includes a beam direction adjustment unit composed of a bending magnet, thereby enabling efficient treatment of patients using multiple beams and multiple targets. Attached Figure Description

[0012] Figure 1 This is a structural block diagram of a neutron beam generation system according to an embodiment of the present disclosure.

[0013] Figure 2 This is a perspective view of a neutron beam generation system according to an embodiment of the present disclosure.

[0014] Figure 3 This is a cross-sectional view of an incident device according to an embodiment of the present disclosure.

[0015] Figure 4 This is a cross-sectional view of a low-energy accelerator tube according to an embodiment of the present disclosure.

[0016] Figure 5 This is a cross-sectional view of a high-energy accelerator tube according to an embodiment of this disclosure.

[0017] Figure 6 This is a side sectional view of the wire and target material according to an embodiment of the present disclosure.

[0018] Figure 7 This is a top cross-sectional view of the wire bundle and target material according to an embodiment of the present disclosure.

[0019] (Explanation of reference numerals in the attached image) 110: Receiver; 120: RF linear accelerator 130: Cable harness 140: Cable harness direction adjustment unit 150: Beam scanning section; 160: Target material 170: Reduction assembly. Detailed Implementation

[0020] The following detailed description of some embodiments of this disclosure is provided in conjunction with exemplary accompanying drawings. It should be noted that when adding reference numerals to the constituent elements of each figure, the same constituent elements will be given the same numerals as much as possible, even if they are shown in different figures. Furthermore, in describing this disclosure, detailed descriptions of relevant well-known structures or functions will be omitted if it is determined that such detailed descriptions may obscure the main points of this disclosure.

[0021] When describing the constituent elements of the present invention, terms such as first, second, A, B, (a), and (b) may be used. These terms are only used to distinguish the constituent element from other constituent elements and do not limit the nature, order, or sequence of the corresponding constituent elements.

[0022] When a constituent element is described as being "connected", "combined", or "linked" with another constituent element, it should be understood that the constituent element can be directly connected or linked with the other constituent element, but there may also be another constituent element "connected", "combined", or "linked" between the constituent elements.

[0023] Throughout the specification, when a part is referred to as "including" or "possessing" a certain constituent element, unless otherwise stated, this does not mean that other constituent elements are excluded, but rather that the part may further include other constituent elements.

[0024] The terms "...section" and "module" used in the instruction manual refer to a unit that performs at least one function or operation, which can be implemented through hardware, software, or a combination of hardware and software.

[0025] It should be noted that, unless otherwise stated, the description of any embodiment is equally applicable to other embodiments.

[0026] The following description of the invention, taken in conjunction with the accompanying drawings, is intended to describe exemplary embodiments of the invention, and not to show the only embodiments in which the invention can be implemented.

[0027] Figure 1This is a structural block diagram of a neutron beam generation system according to an embodiment of the present disclosure.

[0028] Figure 2 This is a perspective view of a neutron beam generation system according to an embodiment of the present disclosure.

[0029] Figure 3 This is a cross-sectional view of an incident device according to an embodiment of the present disclosure.

[0030] Figure 4 This is a cross-sectional view of a low-energy accelerator tube according to an embodiment of the present disclosure.

[0031] Figure 5 This is a cross-sectional view of a high-energy accelerator tube according to an embodiment of this disclosure.

[0032] Figure 6 This is a side sectional view of the wire and target material according to an embodiment of the present disclosure.

[0033] Figure 7 This is a top cross-sectional view of the wire bundle and target material according to an embodiment of the present disclosure.

[0034] Reference Figures 1 to 7 A neutron beam generation system 100 according to an embodiment of the present disclosure may include an injector 110, an RF linear accelerator 120, a beamline 130, a beam direction adjustment unit 140, a beam scanning unit 150, a target 160, a beam shaping assembly 170 (BSA), and an LLRF (Low Level Radio Frequency) device (not shown) for RF (Radio Frequency) control.

[0035] The incident device 110 may include an ion source device 111 and a LEBT (Low Energy Beam Transport) device 112.

[0036] The RF linear accelerator 120 may include a low-energy accelerator 121 and a high-energy accelerator 122.

[0037] The deceleration assembly 170 may include a fast neutron filter 171, a deceleration element 172, and a collimator 173.

[0038] The incident device 110 is configured to generate a proton beam. The incident device 110 can be an ion source. The incident device 110 can extract positive hydrogen ions using a potential difference. The incident device 110 is connected to an RF linear accelerator 120. The incident device 110 generates a proton beam and transmits it to the RF linear accelerator 120. The incident device 110 can create a high-density plasma environment to generate a high-current (e.g., peak current above 40 mA) proton beam. The incident device 110 can accelerate and focus the proton beam using an electric field. The incident device 110 can accelerate the proton beam to a beam energy above 50 keV.

[0039] Ion source device 111 generates a proton beam. Ion source device 111 can extract positive hydrogen ions using a potential difference (e.g., 50 kV). Ion source device 111 can create a high-density plasma environment using a dual plasma tube to generate a high-current proton beam. To stably generate high-density plasma, ion source device 111 can form pulsed plasma. Ion source device 111 can accelerate and focus the proton beam using an electric field. Ion source device 111 can be connected to LEBT device 112. Ion source device 111 can transmit the generated proton beam to LEBT device 112.

[0040] The LEBT device 112 is configured to transmit the proton beam generated by the ion source device 111 to the RF linear accelerator 120. The LEBT device 112 can be connected to both the ion source device 111 and the RF linear accelerator 120. The LEBT device 112 can be positioned between the ion source device 111 and the RF linear accelerator 120. The LEBT device 112 may include a chamber 310 for diagnosing beam size, etc. Hydrogen gas is inevitably generated in the dual plasma tubes of the ion source device 111, and to stably supply a high current, it is necessary to maintain the interior of the LEBT device 112 and the RF linear accelerator 120, etc., at near-vacuum. Therefore, the LEBT device 112 of this disclosure may further include a pump for drawing hydrogen gas from the interior of the chamber 310, etc. Furthermore, as... Figure 3 As shown, a throttling orifice structure 320 is formed on the chamber 310 to minimize the amount of hydrogen gas other than protons transferred from the LEBT device 112 to the RF linear accelerator 120. Accordingly, the vacuum level inside the LEBT device 112 and the RF linear accelerator 120 can be increased, thereby enabling stable proton beam transmission and high current supply.

[0041] The LEBT device 112 is configured to transport only protons (H+) from multiple types of hydrogen gas (e.g., H+, H2+, H3+, etc.) to the RF linear accelerator 120. For example, the LEBT device 112 may include a solenoid magnet 330. The LEBT device 112 can use the solenoid magnet 330 to accelerate and focus only protons from the multiple types of hydrogen gas and transport them to the RF linear accelerator 120, while the remainder can be pushed towards the wall of the beam transport tube, etc. The LEBT device 112 may include multiple solenoid magnets 330. Accordingly, protons can be focused more efficiently, and H2+ and H3+ can be separated.

[0042] The RF linear accelerator 120 is configured to accelerate a proton beam transmitted by the incident device 110. The RF linear accelerator 120 can be connected to the LEBT device 112 of the incident device 110. The RF linear accelerator 120 can be connected to the beamline 130 to transmit the accelerated proton beam to the beamline 130. The RF linear accelerator 120 of this disclosure can accelerate a proton beam to a beam energy of 10 MeV or higher and a power of 25 kW or higher. When the RF linear accelerator 120 accelerates the proton beam to a beam energy of 10 MeV or higher and a beam power of 25 kW or higher, the supply current can be 25 mA. The RF linear accelerator 120 may include a low-energy accelerating tube 121 and a high-energy accelerating tube 122, thereby enabling the proton beam to be accelerated to a beam energy of 10 MeV or higher and a beam power of 25 kW or higher while having a compact size.

[0043] The low-energy accelerating tube 121 is connected to the LEBT device 112 and configured to accelerate a proton beam transmitted from the LEBT device 112. The low-energy accelerating tube 121 of this disclosure can be an RFQ (Radio Frequency Quadrupole) accelerating tube. The low-energy accelerating tube 121 can be configured to accelerate and focus the proton beam using an electric field. When accelerating and focusing a proton beam using an electric field, the transmission rate may be lower than when using a magnetic field. However, for low-energy proton beams, extremely strong magnetic fields are required for acceleration and focusing, making it difficult to achieve acceleration and focusing using a magnetic field. Therefore, the low-energy accelerating tube 121 is configured to accelerate and focus the low-energy proton beam transmitted from the LEBT device 112 to a specified energy level (e.g., 3 MeV) using an electric field. Conversely, when accelerating and focusing a high-energy (e.g., above 3 MeV) proton beam using an electric field, the strong electric field may induce a breakdown phenomenon. Here, breakdown refers to electrostatic damage, resulting in the inability to produce neutrons within a corresponding time period. To prevent breakdown, the low-energy accelerator tube 121 of this disclosure is designed to reduce the intensity of the electric field. Specifically, the low-energy accelerator tube 121 can be designed to increase the difference between the resonant frequency of the quadrupole mode and the resonant frequency of the dipole mode. When the difference in resonant frequencies between the two modes decreases, a metal rod (dipole stabilizer rod) is inserted into the low-energy accelerator tube 121, such as in the RFQ, to increase the difference in resonant frequencies between the two modes. At this time, the inserted metal rod may increase the electric field intensity. In addition, a pump can be arranged near the inlet of the low-energy accelerator tube 121 to draw in and discharge hydrogen gas generated by the dual plasma tubes of the ion source device 111 before it flows into the low-energy accelerator tube 121, thereby increasing the vacuum level inside the low-energy accelerator tube 121. As a result, the low-energy accelerating tube 121 of this disclosure is able to stably accelerate the proton beam transmitted from the LEBT device 112 to a beam energy of 2 MeV to 4 MeV, preferably to 3 MeV.

[0044] A high-energy accelerating tube 122 is connected to a low-energy accelerating tube 121 to accelerate a proton beam transmitted from the low-energy accelerating tube 121. The high-energy accelerating tube 122 of this disclosure can be a DTL (Drift Tube Linear Accelerator). The high-energy accelerating tube 122 can be configured to focus the proton beam using a magnetic field. When focusing the proton beam using a magnetic field, the transmission rate is higher than when using an electric field. However, as mentioned above, it is difficult to focus a low-energy proton beam using a magnetic field. Accordingly, the technical feature of the RF linear accelerator 120 of this disclosure is that it uses the low-energy accelerating tube 121 to accelerate and focus a low-energy proton beam to a specified energy level (e.g., 3 MeV), and uses the high-energy accelerating tube 122 to accelerate the proton beam accelerated to the specified energy level using an electric field and to focus it using a magnetic field, thereby enabling the proton beam to be stably and efficiently accelerated to a high energy level (e.g., 10 MeV). The high-energy accelerator tube 122 disclosed herein can be designed, through simulation or other means, to achieve a proton beam transmission efficiency close to 100%.

[0045] The beam direction adjustment unit 140 is configured to adjust the direction of the proton beam accelerated and focused by the RF linear accelerator 120. The beam direction adjustment unit 140 can be disposed between the RF linear accelerator 120 and the beamline 130. The beam direction adjustment unit 140 can also be disposed on the beamline 130. For example, as... Figure 6 and Figure 7 As shown, when the neutron beam generation system 100 of this disclosure includes a triplet lens group 610 for focusing a proton beam and a beam scanning unit 150 for high-speed scanning of the proton beam, the beam direction adjustment unit 140 can also be configured between the triplet lens group 610 and the beam scanning unit 150 on the beamline 130. However, it should be noted that the position of the beam direction adjustment unit 140 is not limited to the aforementioned situation, and can also be configured in other suitable positions as appropriate. The beam direction adjustment unit 140 may include a bending magnet. According to an embodiment of this disclosure, the beam direction adjustment unit 140 is configured to adjust the direction of the proton beam and includes multiple beamlines 130, multiple targets 160, and multiple deceleration components 170, thereby solving the problem of low patient treatment efficiency caused by long target replacement time (radiation cooling requires 2-3 days), thereby enabling efficient treatment of patients.

[0046] A beamline 130 is disposed between the RF linear accelerator 120 and the target 160, and is connected to both the RF linear accelerator 120 and the target 160. The beamline 130 is configured to transmit the proton beam accelerated by the RF linear accelerator 120 to the target. A triple lens group 610 may be disposed on the beamline 130 to focus the proton beam, ensuring that the proton beam transmitted along the length (e.g., 8 m) of the beamline 130 does not diffuse and can be stably transmitted to the target. The triple lens group 610 may be configured to consist of multiple lenses (e.g., convex lenses, concave lenses) arranged sequentially along the direction of proton beam movement. Furthermore, when the proton beam concentrates its impact on a narrow area of ​​the target 160, the lifetime of the target 160 may be shortened. Therefore, by performing high-speed scanning of the proton beam to expand the area of ​​the proton beam impacting the target 160, the lifetime of the target 160 can be extended. For this purpose, a beam scanning unit 150 may be disposed on the beamline 130. The beam scanning unit 150 may include a scanning magnet. As previously described, a beam direction adjustment unit 140 may be disposed between the beam scanning unit 150 and the triple lens group 610.

[0047] The target 160 is accelerated by the RF linear accelerator 120 and collides with the proton beam transmitted by the beamline 130, generating fast neutrons. The target 160 may be configured to be positioned on one side of the beamline 130. The target 160 may be configured to be surrounded by a deceleration assembly 170. The target 160 may be made of lithium or beryllium, which smoothly generate neutrons by colliding with the proton beam. However, when the target 160 is made of lithium, there are problems with radioactivity and stability. When the target 160 is made of beryllium, stability is ensured, but a high beam energy is required for the proton beam to collide with the beryllium target 160 and generate neutrons. The neutron beam generation system 100 of this disclosure can stably accelerate the proton beam to a beam energy of 10 MeV using the RF linear accelerator 120, which includes a low-energy accelerating tube 121 and a high-energy accelerating tube 122, thus enabling stable neutron generation by using a beryllium target 160.

[0048] The deceleration assembly 170 can be disposed on one side of the beamline 130. The deceleration assembly 170 can be disposed at one end of the beamline 130. The deceleration assembly 170 is configured to decelerate fast neutrons generated by the collision of the proton beam with the target 160 into hyperthermal neutrons.

[0049] The speed reduction component 170 disclosed herein can be configured to have a conversion efficiency of 5 × 10⁻⁶. 7 The conversion efficiency can refer to the number of hyperthermic neutrons generated per kilowatt (kW) of proton beam power. For example, the neutron beam generation system 100 of this disclosure can accelerate a proton beam to a beam power of 25 kW; when the conversion efficiency of the deceleration assembly 170 is 5 × 10⁻⁶, the conversion efficiency is 5 × 10⁻⁶ kW. 7 At a rate of _ / kW, the number of superthermal neutrons generated is The number exceeds the number required for effective neutron capture therapy. This indicates that it is suitable for neutron capture therapy.

[0050] The deceleration assembly 170 may include: a fast neutron filter 171; a moderator 172 disposed in front of the target 160 to reduce the energy of neutrons scattered along the incident direction of the proton beam; a collimator 173 that focuses neutrons onto the affected area of ​​the patient; and a reflector (not shown) that houses the moderator 172 and the collimator 173 to shield against leakage of hyperthermic neutrons and gamma rays to the outside. The deceleration assembly 170 may also include a neutron reflector (not shown) disposed outside the end of the beamline 130 and behind the target 160, configured to reflect neutrons scattered rearward from the target 160 forward. The neutron reflector may be made of a material such as lead that has the property of reflecting neutrons scattered rearward from the target 160. The deceleration assembly 170 disclosed herein includes a neutron reflector, which reflects neutrons lost due to scattering toward the rear of the target 160 back toward the target, thereby achieving excellent superthermal neutron flux.

[0051] The diverse implementations of the systems and technologies described in this specification can be implemented as digital electronic circuits, integrated circuits, FPGAs (field programmable gate arrays), ASICs (application-specific integrated circuits), computer hardware, firmware, software, and / or combinations thereof. These diverse implementations may include implementations by one or more computer programs that execute on a programmable system. The programmable system includes at least one programmable processor (which may be a dedicated or general-purpose processor) combined in a manner that receives and transmits data and instructions from and to a storage system, at least one input device, and at least one output device. The computer program (also referred to as a program, software, software application, or code) includes instructions for the programmable processor and is stored on a computer-readable recording medium.

[0052] Computer-readable recording media include all types of recording devices that store data readable by a computer system. Such computer-readable recording media can be non-volatile or non-transitory media such as ROM, CD-ROM, magnetic tape, floppy disk, memory card, hard disk, magneto-optical disk, and storage devices, and may further include transitory media such as data transmission medium. Furthermore, computer-readable recording media can be distributed across networked computer systems, thereby enabling the distributed storage and execution of computer-readable code.

[0053] The diverse implementations of the systems and technologies described in this specification can be implemented using a programmable computer. Here, a computer includes a programmable processor, a data storage system (including volatile memory, non-volatile memory, or other types of storage systems or combinations thereof), and at least one communication interface. For example, a programmable computer can be one of a server, network device, set-top box, embedded device, computer expansion module, personal computer, laptop computer, PDA (Personal Data Assistant), cloud computing system, or mobile device.

[0054] The above description is merely an illustrative representation of the technical concept of this embodiment. Those skilled in the art to which this embodiment pertains will be able to make various modifications and variations without departing from the essential characteristics of this embodiment. Therefore, this embodiment is intended to illustrate, not limit, the technical concept of this embodiment, and these embodiments do not limit the scope of the technical concept of this embodiment. The scope of protection of this embodiment should be interpreted by the following claims, and all technical concepts within the equivalent scope should be interpreted as falling within the scope of the rights of this embodiment.

[0055] [Cross-references to related applications] This application is a continuation of international application PCT / KR2023 / 004714, filed on April 7, 2023, which is based on and claims priority to Korean Patent Application No. 10-2023-0045522, filed in Korea on April 6, 2023. The entire disclosure of the above application is incorporated herein by reference.

Claims

1. A neutron beam generation system, comprising: The incident device generates a proton beam; An RF linear accelerator, connected to the incident device, is used to accelerate the proton beam; A beamline that transmits the proton beam accelerated by the RF linear accelerator; A target material that collides with the proton beam transmitted by the beamline and generates fast neutrons; and A deceleration assembly, disposed on one side of the beam, is configured to decelerate the fast neutrons into hyperthermal neutrons.

2. The neutron beam generation system according to claim 1, wherein, The neutron beam generating system is configured to generate 1×10 9 pcs / cm 2 The superthermal neutrons are generated by a superthermal neutron flux of more than 1 second.

3. The neutron beam generation system according to claim 2, wherein, The neutron beam generating system is configured to continuously generate the hyperthermal neutrons for more than 40 minutes.

4. The neutron beam generation system according to claim 1, wherein, The incident device includes: An ion source device that generates the proton beam; and A low-energy beam transport device that transports the proton beam to the RF linear accelerator.

5. The neutron beam generation system according to claim 3, wherein, The incident device is an ion source type.

6. The neutron beam generation system according to claim 4, wherein, The ion source device is configured to generate the proton beam using a potential difference.

7. The neutron beam generation system according to claim 6, wherein, The ion source device is configured to generate positive hydrogen ions.

8. The neutron beam generation system according to claim 4, wherein, The ion source device is configured to accelerate and focus the proton beam using an electric field.

9. The neutron beam generation system according to claim 8, wherein, The ion source device accelerates the proton beam to an energy of 50 keV.

10. The neutron beam generation system according to claim 4, wherein, The ion source device generates the proton beam using a plasma environment.

11. The neutron beam generation system according to claim 10, wherein, The ion source device generates the plasma environment using dual plasma tubes.

12. The neutron beam generation system according to claim 10, wherein, The ion source device generates a proton beam with a peak current of 40mA or higher.

13. The neutron beam generation system according to claim 10, wherein, The ion source device generates pulsed plasma.

14. The neutron beam generation system according to claim 4, wherein, The LEBT device includes a solenoid magnet.

15. The neutron beam generation system according to claim 14, wherein, The solenoid magnet is multiple.

16. The neutron beam generation system according to claim 4, wherein, The LEBT device includes: Chambers; and One or more pumps are connected to the chamber.

17. The neutron beam generation system according to claim 16, wherein, The chamber includes a throttling orifice structure.

18. The neutron beam generation system according to claim 1, wherein, The RF linear accelerator accelerates the proton beam to an energy of 10 MeV or higher.

19. The neutron beam generation system according to claim 18, wherein, The power of the proton beam is above 25 kW.

20. The neutron beam generation system according to claim 1, wherein, The RF linear accelerator includes a low-energy accelerator tube and a high-energy accelerator tube.

21. The neutron beam generation system according to claim 20, wherein, The low-energy accelerating tube is a radio frequency tetrode, and the high-energy accelerating tube is a drift tube linear accelerator.

22. The neutron beam generation system according to claim 20, wherein, The low-energy accelerator tube accelerates the proton beam to below 3 MeV.

23. The neutron beam generation system according to claim 22, wherein, The high-energy accelerator tube accelerates the proton beam, which is accelerated by the low-energy accelerator tube, to a beam energy of 10 MeV or higher.

24. The neutron beam generation system according to claim 20, wherein, The low-energy accelerating tube uses an electric field to accelerate and focus the proton beam.

25. The neutron beam generation system according to claim 20, wherein, The high-energy accelerator tube uses a magnetic field to accelerate and focus the proton beam.

26. The neutron beam generation system according to claim 20, wherein, The low-energy accelerator tube is designed such that the difference between the resonant frequency of the quadrupole mode and the resonant frequency of the dipole mode is relatively large.

27. The neutron beam generation system according to claim 20, wherein, The low-energy acceleration tube is equipped with one or more pumps.

28. The neutron beam generating system according to claim 1, further comprising: The beam direction adjustment unit is configured to adjust the direction of the proton beam.

29. The neutron beam generation system according to claim 28, wherein, The beam direction adjustment unit includes one or more deflection magnets.

30. The neutron beam generation system according to claim 28, wherein, There are multiple bundles, target materials, and deceleration components.

31. The neutron beam generation system according to claim 1, wherein, The beamline is equipped with a triple lens group configured to focus the proton beam.

32. The neutron beam generation system according to claim 31, wherein, The triple lens group includes one or more lenses.

33. The neutron beam generation system according to claim 32, wherein, The one or more lenses are arranged sequentially along the direction of movement of the proton beam.

34. The neutron beam generation system according to claim 1, further comprising: A beam scanning unit, which is disposed on the beamline, scans the proton beam.

35. The neutron beam generation system according to claim 1, further comprising: The target material is made of beryllium.

36. The neutron beam generation system according to claim 1, wherein, The conversion efficiency of the deceleration component is 5×10. 7 Units per kW or more.

37. The neutron beam generation system according to claim 1, wherein, The deceleration assembly includes a neutron reflector that reflects neutrons scattered toward the rear of the target toward the target.

38. The neutron beam generation system according to claim 37, wherein, At least a portion of the neutron reflector is made of lead.

39. The neutron beam generation system according to claim 1, wherein, The deceleration assembly is disposed at the end of the wire and configured to accommodate the target material.

40. The neutron beam generation system according to claim 1, wherein, The deceleration component includes: A deceleration component, disposed in front of the target, reduces the energy of the fast neutrons scattered along the incident direction of the proton beam; A collimator that focuses the hyperthermal neutrons onto the affected area of ​​the patient; and A reflector that houses the deceleration element and the collimator to shield the superheated neutrons and gamma rays from leakage to the outside.

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