Sterilization composition containing Xinjunan or Xinjunan acetate and metconazole and application thereof

Abstract

The invention relates to the field of pesticides, in particular to a sterilization composition containing Xinjunan or Xinjunan acetate and metconazole and application of the sterilization composition, and aims at solving the problems that an existing sterilization agent is limited in sterilization effect, pathogenic bacteria easily generate drug resistance after being singly used for a long time, and the prevention and treatment effect is reduced. According to the bactericidal composition, the bactericidal effect is achieved by utilizing different action mechanisms of the xinjunan or the xinjunan acetate and the metconazole, the xinjunan and the metconazole have a remarkable synergistic effect after being compounded, the control effect on pathogenic bacteria can be improved, and the drug resistance risk of the pathogenic bacteria is reduced. The action mechanisms of the two effective components are different, the two effective components are compounded for use, pathogenic bacteria can be inhibited from a plurality of target spots, the bactericidal spectrum can be expanded, a good prevention and treatment effect on various crop diseases is achieved, the possibility that the pathogenic bacteria generate drug resistance to a single agent is reduced, and the service life of the agent is prolonged.

Description

Technical Field

[0001] This invention relates to the field of pesticides, and more specifically to a fungicide composition containing cyprodinil or cyprodinil acetate and tebuconazole, and its application. Background Technology

[0002] Crop diseases are a significant factor affecting agricultural production, seriously threatening crop yield and quality. Chemical control is currently the main method for controlling crop diseases, but long-term use of the same fungicide can easily lead to drug resistance in pathogens, reducing the effectiveness of control. Therefore, developing novel fungicides that are highly efficient, low in toxicity, environmentally friendly, and can delay the development of drug resistance is of great importance.

[0003] Cyprodinil or cyprodinil acetate is an organic amine fungicide. Its mechanism of action is to disrupt the cell membrane of pathogens, causing the cell contents to leak out, thereby leading to the death of the pathogens. Cyprodinil has broad-spectrum fungicidal activity, with certain control effects against diseases caused by various fungi, bacteria, and viruses. It also has systemic and translocative properties, allowing it to be absorbed by plants and translocated within them, thus providing both preventative and curative effects against plant diseases. However, long-term use of cyprodinil can lead to drug resistance in pathogens, and its control effect on certain stubborn diseases is limited.

[0004] Imidacloprid belongs to the triazole fungicide class. It kills pathogens by inhibiting the biosynthesis of ergosterol within the fungus, thereby disrupting the structure and function of the pathogen's cell membrane. Imidacloprid is characterized by strong systemic activity and a long-lasting effect, showing good control efficacy against various higher fungal diseases such as powdery mildew, rust, and leaf spot. However, its fungicidal spectrum is relatively narrow, and it is less effective against some lower fungal and bacterial diseases.

[0005] Combining fungicides with different mechanisms of action is an effective way to address pathogen resistance and broaden the fungicidal spectrum. Currently, there are no reports on fungicidal compositions of cymoxanil or cymoxanil acetate combined with tebuconazole and their applications. Summary of the Invention

[0006] In order to overcome the above-mentioned technical problems, the present invention aims to provide a fungicide composition containing cymoxanil or cymoxanil acetate and tebuconazole and its application, which solves the problems that existing fungicides have limited fungicide activity and that long-term single use can easily lead to the development of drug resistance in pathogens, resulting in a decline in the control effect.

[0007] The objective of this invention can be achieved through the following technical solutions:

[0008] A bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising 30-70% by weight of the active ingredient, with the remainder being excipients;

[0009] The active ingredients include a first active ingredient and a second active ingredient;

[0010] The first active ingredient is octochlor or octochlor acetate;

[0011] The second active ingredient is tebuconazole;

[0012] The mass ratio of the first active ingredient to the second active ingredient is (1-10):(1-20).

[0013] As a further aspect of the present invention: the mass ratio of the first effective component to the second effective component is (1-5):(5-10).

[0014] As a further aspect of the present invention, the mass ratio of the first effective component to the second effective component is 5:10.

[0015] As a further aspect of the present invention, the dosage form of the bactericidal composition includes, but is not limited to, wettable powder, suspension concentrate, water-dispersible granules, water emulsion, emulsifiable concentrate, and microemulsion.

[0016] As a further aspect of the present invention: the bactericidal composition is a wettable powder, wherein the excipients in the wettable powder include a dispersant, a wetting agent, and a filler; the dispersant is one of sodium dodecylbenzene sulfonate and sodium lignosulfonate; the wetting agent is one of a separating powder and sodium dodecyl sulfate; and the filler is one of diatomaceous earth and kaolin.

[0017] As a further aspect of the present invention: the bactericidal composition is a suspending agent, wherein the excipients in the suspending agent include a dispersant, an emulsifier, a thickener, an antifreeze agent, an antifoaming agent, and deionized water; the dispersant is one of SP-3275 polycarboxylate dispersant and SP-27001 polycarboxylate dispersant; the emulsifier is one of agricultural emulsion No. 600 and agricultural emulsion No. 700; the thickener is xanthan gum; the antifreeze agent is one of ethylene glycol and propylene glycol; and the antifoaming agent is antifoaming agent DF-520.

[0018] As a further aspect of the present invention: the bactericidal composition is a water-dispersible granule, wherein the excipients in the water-dispersible granule include a dispersant, a wetting agent, a disintegrant, a binder, and a filler; the dispersant is one of naphthalene sulfonate dispersant SP-2818 and polycarboxylate dispersant SP-2836; the wetting agent is one of a dispersing agent and sodium dodecyl sulfate; the disintegrant is one of ammonium sulfate and sodium bicarbonate; the binder is starch; and the filler is one of diatomaceous earth and kaolin.

[0019] As a further aspect of the present invention: the application of the fungicidal composition containing octochlor or octochlor acetate and tebuconazole in the prevention and control of crop diseases.

[0020] As a further aspect of the present invention, the diseases include, but are not limited to, Fusarium head blight, powdery mildew, rust, leaf spot, anthracnose, sheath blight, rice blast, damping-off, root rot, wilt, and canker.

[0021] The beneficial effects of this invention are:

[0022] This invention discloses a fungicidal composition containing cyprodinil or cyprodinil acetate and tebuconazole, and its application. By utilizing the different mechanisms of action of cyprodinil or cyprodinil acetate and tebuconazole, the fungicidal effect is achieved. The combination of the two exhibits a significant synergistic effect, improving the control efficacy against pathogens and reducing the risk of pathogen resistance. The two active ingredients have different mechanisms of action, allowing for multi-target inhibition of pathogens, broadening the fungicidal spectrum, and providing good control against various crop diseases. Furthermore, it reduces the possibility of pathogens developing resistance to single agents and extends the lifespan of the agents. Moreover, due to the excellent synergistic effect, the dosage of the combined fungicidal composition is reduced compared to using either agent alone, thereby lowering application costs, improving economic efficiency, and ensuring crop safety and environmental friendliness, meeting the requirements of modern green pest control in agriculture. Detailed Implementation

[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0024] Example 1:

[0025] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0026] Weigh the following components according to the following mass ratio: 40% active ingredient, 3% dispersant, 2% wetting agent, and filler to make up to 100%; wherein, the mass ratio of cymoxanil and tebuconazole in the active ingredient is 5:5; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is a separating powder; and the filler is diatomaceous earth.

[0027] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤44μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole in the form of a wettable powder.

[0028] Example 2:

[0029] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0030] Weigh the following components according to the following mass ratio: 45% active ingredient, 4.5% dispersant, 3% wetting agent, and filler to bring the total to 100%; wherein, the mass ratio of cymoxanil and tebuconazole in the active ingredient is 5:10; the dispersant is sodium dodecylbenzenesulfonate; the wetting agent is sodium dodecyl sulfate; and the filler is diatomaceous earth.

[0031] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤44μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole in the form of a wettable powder.

[0032] Example 3:

[0033] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0034] Weigh the following components according to the following mass ratio: 50% active ingredient, 6% dispersant, 4% wetting agent, and filler to make up to 100%; wherein, the mass ratio of octochlor acetate and tebuconazole in the active ingredient is 1:5; the dispersant is sodium lignosulfonate; the wetting agent is sodium dodecyl sulfate; and the filler is kaolin.

[0035] The components are mixed evenly and then pulverized by an air jet mill to a particle size ≤44μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole in the form of a wettable powder.

[0036] Example 4:

[0037] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0038] Weigh the following components according to the following mass ratio: 30% active ingredient, 3% dispersant, 2% emulsifier, 0.3% thickener, 3% antifreeze, 0.4% defoamer, and deionized water to bring the total to 100%; wherein, the mass ratio of cymoxanil and tebuconazole in the active ingredient is 5:5; the dispersant is SP-3275 polycarboxylate dispersant; the emulsifier is agricultural emulsion 600; the thickener is xanthan gum; the antifreeze is ethylene glycol; and the defoamer is defoamer DF-520.

[0039] The components are mixed evenly and ground in a sand mill until the particle size is ≤5μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole in the form of a suspension.

[0040] Example 5:

[0041] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0042] Weigh the following components according to the following mass ratio: 35% active ingredient, 3.5% dispersant, 2.5% emulsifier, 0.4% thickener, 4% antifreeze, 0.5% defoamer, and deionized water to bring the total to 100%; wherein, the mass ratio of cymoxanil and tebuconazole in the active ingredient is 5:10; the dispersant is SP-3275 polycarboxylate dispersant; the emulsifier is agricultural emulsion 700; the thickener is xanthan gum; the antifreeze is propylene glycol; and the defoamer is defoamer DF-520.

[0043] The components are mixed evenly and ground in a sand mill until the particle size is ≤5μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole in the form of a suspension.

[0044] Example 6:

[0045] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0046] Weigh the following components according to the following mass ratio: 40% active ingredient, 4% dispersant, 3% emulsifier, 0.5% thickener, 5% antifreeze, 0.6% defoamer, and deionized water to bring the total to 100%; wherein, the mass ratio of octochlor acetate and tebuconazole in the active ingredient is 1:5; the dispersant is SP-27001 polycarboxylate dispersant; the emulsifier is agricultural emulsion 700; the thickener is xanthan gum; the antifreeze is propylene glycol; and the defoamer is defoamer DF-520.

[0047] The components are mixed evenly and ground in a sand mill until the particle size is ≤5μm to obtain a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole in the form of a suspension.

[0048] Example 7:

[0049] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0050] The following components are weighed according to the following mass ratio: 35% active ingredient, 5% dispersant, 3% wetting agent, 8% disintegrant, 3% binder, and filler to 100%; wherein, the mass ratio of octochlor and tebuconazole in the active ingredient is 5:5; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is one of dispersing powder and sodium dodecyl sulfate; the disintegrant is one of ammonium sulfate and sodium bicarbonate; the binder is starch; and the filler is one of diatomaceous earth and kaolin.

[0051] The components are mixed evenly and then pulverized by air jet milling to a particle size ≤150μm. After granulation and drying by a granulation and drying machine, a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole is obtained in the form of water-dispersible granules.

[0052] Example 8:

[0053] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0054] The following components are weighed according to the following mass ratio: 40% active ingredient, 6% dispersant, 4% wetting agent, 9% disintegrant, 3.5% binder, and filler to 100%; wherein, the mass ratio of cymoxanil and tebuconazole in the active ingredient is 5:10; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is sodium dodecyl sulfate; the disintegrant is ammonium sulfate; the binder is starch; and the filler is kaolin.

[0055] The components are mixed evenly and then pulverized by air jet milling to a particle size ≤150μm. After granulation and drying by a granulation and drying machine, a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole is obtained in the form of water-dispersible granules.

[0056] Example 9:

[0057] This embodiment describes a method for preparing a bactericidal composition containing octochlor or octochlor acetate and tebuconazole, comprising the following steps:

[0058] The following components are weighed according to the following mass ratio: 45% active ingredient, 7% dispersant, 5% wetting agent, 10% disintegrant, 4% binder, and filler to bring the total to 100%; wherein, the mass ratio of octochlor acetate and tebuconazole in the active ingredient is 1:5; the dispersant is polycarboxylate dispersant SP-2836; the wetting agent is sodium dodecyl sulfate; the disintegrant is sodium bicarbonate; the binder is starch; and the filler is kaolin.

[0059] The components are mixed evenly and then pulverized by air jet milling to a particle size ≤150μm. After granulation and drying by a granulation and drying machine, a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole is obtained in the form of water-dispersible granules.

[0060] Comparative Example 1:

[0061] This comparative example illustrates a method for preparing a bactericidal composition containing octochlor, comprising the following steps:

[0062] Weigh the following components according to the following mass ratio: 40% active ingredient, 6% dispersant, 4% wetting agent, 9% disintegrant, 3.5% binder, and filler to make up to 100%; wherein, the active ingredient is octochlor; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is sodium dodecyl sulfate; the disintegrant is ammonium sulfate; the binder is starch; and the filler is kaolin.

[0063] The components are mixed evenly and then pulverized by air jet milling to a particle size ≤150μm. After granulation and drying by a granulation and drying machine, a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole is obtained in the form of water-dispersible granules.

[0064] Comparative Example 2:

[0065] This comparative example illustrates a method for preparing a bactericidal composition containing octochlor, comprising the following steps:

[0066] Weigh the following components according to the following mass ratio: 40% active ingredient, 6% dispersant, 4% wetting agent, 9% disintegrant, 3.5% binder, and filler to make up to 100%; wherein, the active ingredient is octochlor acetate; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is sodium dodecyl sulfate; the disintegrant is ammonium sulfate; the binder is starch; and the filler is kaolin.

[0067] The components are mixed evenly and then pulverized by air jet milling to a particle size ≤150μm. After granulation and drying by a granulation and drying machine, a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole is obtained in the form of water-dispersible granules.

[0068] Comparative Example 3:

[0069] This comparative example illustrates a method for preparing a fungicide composition containing tebuconazole, comprising the following steps:

[0070] The following components are weighed according to the following mass ratio: 40% active ingredient, 6% dispersant, 4% wetting agent, 9% disintegrant, 3.5% binder, and filler to make up to 100%; wherein, the active ingredient is tebuconazole; the dispersant is naphthalene sulfonate dispersant SP-2818; the wetting agent is sodium dodecyl sulfate; the disintegrant is ammonium sulfate; the binder is starch; and the filler is kaolin.

[0071] The components are mixed evenly and then pulverized by air jet milling to a particle size ≤150μm. After granulation and drying by a granulation and drying machine, a bactericidal composition containing octenylamine or octenylamine acetate and tebuconazole is obtained in the form of water-dispersible granules.

[0072] The inhibitory effects of the fungicidal compositions of Examples 1-9 and Comparative Examples 1-2 on Fusarium graminearum were determined using the mycelial growth rate method, and the inhibitory concentration EC was measured. 50 The efficacy of fungicides in controlling wheat scab was tested according to NY / T 1464.15-2007, "Field Efficacy Test Guidelines for Pesticides, Part 15: Control of Wheat Fusarium Head Blight by Fungicides". The tested wheat variety was "Xinnong 20 Wheat". Two applications were made at 7-day intervals during the early flowering stage of wheat, with each application at a rate of 60g / 667m². 2 The randomized block design was used with four replicates and a test plot size of 20m. 2 The experiment used a uniform spraying method on the stems and leaves of the plants for pesticide application, with a spray volume of 675L per hectare. The blank control was sprayed with 675L of clean water per hectare.

[0073] The test results are shown in the table below:

[0074]

[0075] Referring to the data in the table above, it can be seen that the rational combination of cymoxanil or cymoxanil acetate with tebuconazole has a significant synergistic effect.

[0076] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0077] The above description is merely an example and illustration of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described or use similar methods to replace them, as long as they do not deviate from the invention or exceed the scope defined in this application, they should all fall within the protection scope of the present invention.

Claims

1. A bactericidal composition containing octochlor or octochlor acetate and tebuconazole, characterized in that, It contains 30-70% active ingredients by weight, with the remainder being excipients; The active ingredients include a first active ingredient and a second active ingredient; The first active ingredient is octochlor or octochlor acetate; The second active ingredient is tebuconazole; The mass ratio of the first active ingredient to the second active ingredient is (1-10):(1-20).

2. The bactericidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 1, characterized in that, The mass ratio of the first active ingredient to the second active ingredient is (1-5):(5-10).

3. The bactericidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 2, characterized in that, The mass ratio of the first active ingredient to the second active ingredient is 5:

10.

4. The bactericidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 1, characterized in that, The dosage forms of the bactericidal composition include, but are not limited to, wettable powders, suspensions, water-dispersible granules, water-emulsions, emulsifiable concentrates, and microemulsions.

5. The bactericidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 4, characterized in that, The bactericidal composition is a wettable powder, and the excipients in the wettable powder include a dispersant, a wetting agent, and a filler; the dispersant is one of sodium dodecylbenzene sulfonate and sodium lignosulfonate; the wetting agent is one of a separating powder and sodium dodecyl sulfate; and the filler is one of diatomaceous earth and kaolin.

6. The bactericidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 4, characterized in that, The bactericidal composition is a suspension concentrate, and the excipients in the suspension concentrate include a dispersant, an emulsifier, a thickener, an antifreeze agent, an antifoaming agent, and deionized water; the dispersant is one of SP-3275 polycarboxylate dispersant and SP-27001 polycarboxylate dispersant; the emulsifier is one of Agricultural Emulsion No. 600 and Agricultural Emulsion No. 700; the thickener is xanthan gum; the antifreeze agent is one of ethylene glycol and propylene glycol; and the antifoaming agent is antifoaming agent DF-520.

7. The bactericidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 4, characterized in that, The bactericidal composition is a water-dispersible granule, and the excipients in the water-dispersible granule include a dispersant, a wetting agent, a disintegrant, a binder, and a filler; the dispersant is one of naphthalene sulfonate dispersant SP-2818 and polycarboxylate dispersant SP-2836; the wetting agent is one of a dispersing agent and sodium dodecyl sulfate; the disintegrant is one of ammonium sulfate and sodium bicarbonate; the binder is starch; and the filler is one of diatomaceous earth and kaolin.

8. The application of the fungicidal composition containing octochlor or octochlor acetate and tebuconazole according to claim 1 in the prevention and control of crop diseases.

9. The application according to claim 8, characterized in that, The diseases mentioned include, but are not limited to, Fusarium head blight, powdery mildew, rust, leaf spot, anthracnose, sheath blight, rice blast, damping-off, root rot, wilt, and canker.

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