Traditional Chinese medicine composition for conditioning consumptive disease syndrome and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for conditioning consumptive disease syndrome and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from 15-20 parts of astragalus membranaceus, 12-15 parts of radix pseudostellariae, 10-15 parts of poria cocos, 10-20 parts of Chinese yam, 10-20 parts of gordon euryale seeds, 5-15 parts of coix seeds, 5-15 parts of black sesame seeds and 10-15 parts of lotus seeds. The traditional Chinese medicine composition is reasonable in compatibility aiming at the core pathogenesis of the consumptive disease syndrome, radix astragali and radix pseudostellariae are taken as monarch drugs, Chinese yam, gordon euryale seed, lotus seed and black sesame are taken as ministerial drugs, poria cocos and coix seed are taken as adjuvant drugs, all the drugs have a synergistic effect, and the traditional Chinese medicine composition has the main effect of strengthening body resistance and the auxiliary effect of eliminating evil, tonifies qi and nourishes yin, and harmonizes upper jiao, middle jiao and lower jiao together (radix astragali and radix pseudostellariae regulate upper jiao, poria cocos, Chinese yam and lotus seed regulate middle jiao and lower jiao); gordon euryale seed and black sesame can regulate lower jiao, repair viscera functions, strengthen spleen and clear damp, prevent stagnation of nourishing, solve the contradiction of'stagnation of tonifying medicine to spleen ', regulate medicine properties, balance dryness of warm tonifying medicine through rhizoma nardostachyos and dryness moistening products, and avoid'attacking and hurting body resistance'.

Description

Technical Field

[0001] This invention relates to the field of pharmaceuticals and health products, and in particular to a traditional Chinese medicine composition for treating asthenia syndrome and its application. Background Technology

[0002] Traditional Chinese medicine (TCM) refers to a general state of chronic weakness, with the core pathogenesis being deficiency of Qi, blood, Yin, and Yang, and decline in organ function. This includes, but is not limited to, chronic fatigue, primarily manifested as long-term fatigue, decreased physical strength, and multi-system dysfunction, which cannot be relieved by rest. Treatment of TCM for this condition often involves tonifying Qi and blood with single or compound formulas, such as using donkey-hide gelatin alone, or combining formulas with Astragalus membranaceus, Codonopsis pilosula, Epimedium, and Angelica sinensis to improve and treat the condition. However, these approaches often overlook the fact that patients with this condition may experience digestive and absorptive disorders due to "inability to tolerate tonification," affecting the efficacy of the medication and its therapeutic effect. Furthermore, while the core principle of these treatments is "strengthening the body's resistance and eliminating pathogenic factors," aggressive approaches can easily damage the body's vital energy, and tonification can easily stagnate the spleen, further leading to poor digestion and absorption. Summary of the Invention

[0003] Therefore, based on the above background, the present invention provides a traditional Chinese medicine composition for treating asthenia syndrome and its application. It addresses the problem of drug absorption disorders caused by "deficiency and intolerance" in asthenia patients. The composition is rationally formulated, which not only avoids gastrointestinal irritation and reduces the occurrence of poor digestion and absorption, but also effectively improves asthenia syndrome.

[0004] The technical solution provided by this invention is as follows:

[0005] A traditional Chinese medicine composition for treating asthenia syndrome, comprising, by weight, the following components:

[0006] Astragalus membranaceus 15-20 parts, Codonopsis pilosula 12-15 parts, Poria cocos 10-15 parts, Dioscorea opposita 10-20 parts, Euryale ferox 10-20 parts, Coix lacryma-jobi 5-15 parts, black sesame 5-15 parts, lotus seed 10-15 parts.

[0007] Furthermore, by weight, it consists of the following components:

[0008] Astragalus membranaceus 18 parts, Codonopsis pilosula 12 parts, Poria cocos 12 parts, Dioscorea opposita 15 parts, Euryale ferox 12 parts, Coix lacryma-jobi 18 parts, black sesame 18 parts, lotus seeds 18 parts.

[0009] Based on the same inventive concept, the present invention also provides the application of a traditional Chinese medicine composition for treating asthenia syndrome in the preparation of a preparation for treating chronic fatigue syndrome.

[0010] Based on the same inventive concept, the present invention also provides the application of a traditional Chinese medicine composition for treating asthenia syndrome in the preparation of a preparation for improving sub-health.

[0011] Furthermore, one of the specific manifestations of sub-health is physical weakness and susceptibility to illness.

[0012] Based on the same inventive concept, the present invention also provides the application of a traditional Chinese medicine composition for treating asthenia syndrome in the preparation of an adjunct hypoglycemic agent.

[0013] Preferably, the preparation is a nutritional powder or a nutritional cake.

[0014] Furthermore, the preparation of the nutritional paste includes the following steps:

[0015] ① Take the raw materials according to the specified amount, crush them, sieve them, and then mix them to obtain a powder;

[0016] ② Add rice wine and maltose to the powder from step ①, stir well, pour into a mold, and bake at low temperature until the moisture content is ≤12%.

[0017] Furthermore, in step ②, the amount of rice wine added is less than 5% of the powder dosage, and the amount of maltose added is less than 20% of the powder dosage.

[0018] This invention addresses the core pathogenesis of asthenospermia syndrome with a rational combination of herbs. Astragalus and Codonopsis are the principal herbs, their combination tonifying both Qi and Yin, supporting the body's vital energy and replenishing deficiencies. Codonopsis neutralizes the warming nature of Astragalus, preventing dryness and heat from damaging Yin. Dioscorea, Euryale ferox, Nelumbo nucifera, and black sesame are the assistant herbs. Dioscorea, Euryale ferox, and Nelumbo nucifera synergistically strengthen the spleen and kidney functions, consolidating essence and preventing further depletion of Qi and blood. The sweet and neutral properties of Dioscorea and Nelumbo nucifera moderate the astringent nature of Euryale ferox, while black sesame nourishes Yin and moistens dryness, providing tonification while moistening, alleviating the potential dryness and stagnation caused by the warming and astringent herbs like Astragalus and Euryale ferox, and guiding the medicine to the lower Jiao to replenish the essence and blood of the liver and kidneys. Poria and Coix seed are the adjuvant herbs, dispelling dampness and turbidity, promoting digestion and preventing the tonifying herbs from stagnating the spleen and stomach, and eliminating the cloying and stomach-damaging effects of Astragalus and other herbs.

[0019] The beneficial effects achieved by this invention are as follows:

[0020] This invention utilizes the synergistic effects of various herbs to primarily strengthen the body's resistance while secondarily eliminating pathogenic factors. It replenishes Qi and nourishes Yin, simultaneously regulating the upper, middle, and lower Jiao (Astragalus and Codonopsis regulate the upper Jiao, Poria, Dioscorea, and Lotus seeds regulate the middle Jiao, and Euryale ferox and black sesame seeds regulate the lower Jiao). This repairs the functions of the internal organs while also strengthening the spleen and removing dampness, preventing stagnation from tonifying herbs, resolving the contradiction of "tonifying herbs causing spleen stagnation," and harmonizing the properties of the herbs. By using sweet, neutral, and moistening herbs to balance the dryness of warming tonics, it avoids "attacking and damaging the body's resistance." Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] Example 1: A traditional Chinese medicine composition for treating asthenia syndrome, comprising the following components by weight:

[0023] Astragalus membranaceus 18 parts, Codonopsis pilosula 12 parts, Poria cocos 12 parts, Dioscorea opposita 15 parts, Euryale ferox 12 parts, Coix lacryma-jobi 18 parts, black sesame 18 parts, lotus seeds 18 parts.

[0024] In practical applications, the above-mentioned Chinese herbal medicine composition can be prepared into nutritional powder or nutritional cake.

[0025] The specific steps for preparing the nutrient powder are as follows:

[0026] After measuring the raw materials, they are dried separately until the moisture content is ≤8%, then ultra-finely pulverized, passed through a 300-mesh sieve, mixed, and prepared into powder, which is then aseptically packaged in nitrogen-filled cans (oxygen residue ≤0.5%).

[0027] When using, take 30-50g of powder, add 200-300ml of water, boil for 3 minutes, and make into a paste for warm consumption.

[0028] Specific steps for preparing nutritional cakes:

[0029] ① Take the raw materials according to the specified amount, crush them, sieve them, and then mix them to obtain powder; the preparation of the powder in this step is the same as the preparation of the nutrient powder above.

[0030] ② Add rice wine and maltose to the powder from step ①, stir well, pour into a mold, and bake at a low temperature of 60℃ until the moisture content is ≤12%.

[0031] In this step, the amount of rice wine added is less than 5% of the powder dosage, and the amount of maltose added is less than 20% of the powder dosage.

[0032] Maltose used in the preparation of nutritional cakes from traditional Chinese medicine compositions has the effects of binding, flavoring, and tonifying the middle jiao (spleen and stomach). Low-temperature baking can preserve active ingredients such as black sesame lignans.

[0033] Fatigue syndrome can be classified as a type of asthenia syndrome, and it is the most common one. Moreover, cancer patients often exhibit weakness during and after treatment, and their weakness is a clinical subtype of asthenia syndrome. Therefore, this invention can be used as an adjuvant drug for cancer treatment or as a prognostic adjuvant after cancer treatment to improve and treat the weakness symptoms of cancer patients.

[0034] Typical Case:

[0035] This invention has been used as an adjunct therapy for cancer patients and other patients with asthenia syndrome in multiple cases, and feedback has been received that it has an effect on improving the symptoms of asthenia. The following are typical cases.

[0036] Case 1: Mr. Cai, male, 68 years old, experienced dribbling urination, generalized bone pain, and weight loss for six months. On November 4, 2023, he underwent relevant examinations at the hospital and was diagnosed with late-stage bladder cancer with bone metastasis throughout his body. Due to his weak constitution, he could not undergo radiotherapy or chemotherapy, so he was given oral targeted drugs, calcium supplements, and nutritional powder prepared in Example 1 as an adjunct treatment. He took 50-80g / day, cooked into a paste and consumed twice a day. His condition gradually improved, and by May 2024, his health had significantly improved. His appetite improved, he ate well, his sleep improved, his weight increased, and his pain decreased. All laboratory test indicators improved. He continued treatment until now, and his health is getting better and better. His diet, sleep, and physical strength are all approaching normal, and his test results are also improving.

[0037] Case 2: Mr. Hu, male, 58 years old, first visited on July 20, 2021. He presented with pale complexion, unsteady head, palpitations, insomnia, bitter taste in the mouth, and cold neck and legs. His blood pressure and blood sugar were normal. He was diagnosed with Qi and Yin deficiency, belonging to the category of general debility. He was treated with the nutritional cake from Example 1, approximately 80-100g daily. After one month, his appetite improved, he felt craving food, his complexion improved, and he had more energy. Most of his previous discomforts disappeared, and he has continued to take the nutritional cake to this day.

[0038] Case 3: Ms. Wang, female, 17 years old, was diagnosed with aplastic anemia at age 12. She sought medical attention on March 10, 2016. At that time, she required blood transfusions approximately every 20 days, had a sallow complexion, and was emaciated. She was then given the nutritional powder described in Example 1, 50-80 grams per day, made into porridge and consumed in two divided doses. The frequency of blood transfusions gradually decreased, and after one year, the need for transfusions was reduced from every 20 days to once every six months.

[0039] Case 4: Ms. Yang, female, 19 years old, consulted on September 3, 2016. She had a constitution of Yin and Yang deficiency, was weak and sickly, had a pale complexion, was weak and fatigued, had excessive sweating of the hands and feet, and irregular menstruation, which corresponded to general weakness. She was treated with the nutritional cake from Example 1, 100-150g per day. After half a year, her sleep improved, her complexion became rosy, her sleep was good, the sweating of her hands and feet disappeared, she rarely caught colds, and her menstruation became normal.

[0040] The present invention and its embodiments have been described above. This description is not restrictive, and the embodiments shown are only one of the embodiments of the present invention. The actual structure is not limited to this. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the present invention, they should all fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating asthenia syndrome, characterized in that, By weight, it consists of the following components: Astragalus membranaceus 15-20 parts, Codonopsis pilosula 12-15 parts, Poria cocos 10-15 parts, Dioscorea opposita 10-20 parts, Euryale ferox 10-20 parts, Coix lacryma-jobi 5-15 parts, black sesame 5-15 parts, lotus seed 10-15 parts.

2. The traditional Chinese medicine composition for treating asthenia syndrome according to claim 1, characterized in that, By weight, it consists of the following components: Astragalus membranaceus 18 parts, Codonopsis pilosula 12 parts, Poria cocos 12 parts, Dioscorea opposita 15 parts, Euryale ferox 12 parts, Coix lacryma-jobi 18 parts, black sesame 18 parts, lotus seeds 18 parts.

3. The use of the traditional Chinese medicine composition for treating chronic fatigue syndrome as described in claim 1 or 2 in the preparation of a preparation for treating chronic fatigue syndrome.

4. The application of the traditional Chinese medicine composition for treating asthenia syndrome as described in claim 1 or 2 in the preparation of preparations for improving sub-health conditions.

5. The application according to claim 4, characterized in that, One of the specific manifestations of sub-health is physical weakness and susceptibility to illness.

6. The use of the traditional Chinese medicine composition for treating asthenia syndrome as described in claim 1 or 2 in the preparation of an adjunct hypoglycemic agent.

7. The application according to any one of claims 3 to 6, characterized in that, The preparation is a nutritional powder or nutritional cake.

8. The application according to claim 7, characterized in that, The preparation of the nutritional paste includes the following steps: ① Take the raw materials according to the specified amount, crush them, sieve them, and then mix them to obtain a powder; ② Add rice wine and maltose to the powder from step ①, stir well, pour into a mold, and bake at low temperature until the moisture content is ≤12%.

9. The application according to claim 8, characterized in that, In step ②, the amount of rice wine added was less than 5% of the powder dosage, and the amount of maltose added was less than 20% of the powder dosage.