Formula and preparation process of cold compress patch capable of being bagged on line

Abstract

The invention discloses a formula of a cold compress patch capable of being bagged on line and a preparation process of the cold compress patch, the specific formula comprises the following raw materials: oil raw materials comprise 400-500 g of glycerol, 300-350 g of sodium polyacrylate, 6-9 g of dihydroxyaluminum aminoacetate and 7-8 g of disodium salt; the water item raw materials comprise 5140 g of purified water, 13.2 g of tartaric acid, 30 g of a cool feeling agent, 60 g of ethyl alcohol, 0.6 g of potassium sorbate and 0.4 g of glucomannan. According to the formula, on the basis of ensuring the water locking effect of the hydrogel, the use amount of glycerol is reduced through the preparation process, so that the material cost for producing the cold compress patch is saved. The cold compress patch is arranged at the joint of the base body layer and the sealing layer, the closed bonding ring is formed through heat sealing, the closed storage space is formed in the inner side area in the bonding ring and used for containing hydrogel, the gel is prevented from overflowing through the closed bonding ring, airing and curing treatment is not needed, field stacking is reduced, and the cost is reduced. And meanwhile, the moisture of the gel can be locked, online bagging can be achieved, the product process steps are reduced, and the delivery speed is increased. A spacing gap with a certain interval is formed on the outer side of the bonding ring, so that the sealing layer can be conveniently separated from the base body layer.

Description

Technical Field

[0001] This invention relates to the field of medical assistive devices, and in particular to a formulation and preparation process of a cold compress that can be packaged online. Background Technology

[0002] Cooling patches are a common type of topical medicated patch, typically used to relieve symptoms of high fever caused by heat. Cooling patches contain a gel layer; their cooling principle involves the evaporation of moisture from the gel layer to absorb heat, thereby lowering the patient's skin temperature and alleviating discomfort caused by high fever.

[0003] The cooling effect of a cold compress mainly depends on the moisture content in the gel layer. If the moisture in the gel layer evaporates too quickly or the gel layer has poor water retention, the cooling duration of the cold compress will be short, affecting its effectiveness. To achieve a better cooling effect, a large amount of glycerin needs to be added to the hydrogel, which keeps the production cost of the cold compress high.

[0004] Currently, the storage structure for gels is too simple. Freshly produced gels are highly fluid and easily disperse, so they need to be dried and cured for a period of time to reduce their fluidity. However, drying and curing require space, and moisture is easily lost during the curing process, resulting in poor cold compress effects. A curing step is necessary before bagging, leading to a long production cycle. Summary of the Invention

[0005] To address the above problems, this invention proposes a formula and preparation process for a cold compress that can be bagged online.

[0006] The technical solution adopted in this invention is: a formula for a cold compress patch that can be packaged online, comprising the following raw materials.

[0007] Oil raw materials:

[0008] (1) 400-500 grams of glycerin;

[0009] (2) Sodium polyacrylate 300-350 grams;

[0010] (3) Aluminum hydroxychloroquine 6-9 grams;

[0011] (4) 7-8 grams of disodium salt;

[0012] Water-based raw materials:

[0013]

[0014] A process for preparing an online bagged cold compress patch includes the following steps.

[0015] S1: Dissolve 0.6 g potassium sorbate and 0.4 g g glucomannan in 4000 g purified water, and dissolve 13.2 g tartaric acid in 1140 g purified water. Then mix the two solutions and stir well before use.

[0016] S2: Take 312g of sodium polyacrylate, 7.8g of aluminum hydroxyl, and 7.2g of disodium salt and mix them evenly in a dry state for later use;

[0017] S3: Place 500g of glycerin in the emulsifier tank, add the mixture obtained in S2 into the emulsifier tank, start the emulsifier and emulsify for 5-6 minutes, then set aside.

[0018] S4: Take 30 grams of cooling agent, dissolve it in 60 grams of ethanol, then pour the mixed solution into a mixing bowl, stir well and set aside.

[0019] S5: Pour the mixed solution and emulsion obtained in steps S1, S3 and S4 into a vacuum stirring tank and cover it with a sealed lid;

[0020] S6: Turn on the vacuum pump to evacuate the vacuum mixing tank. When the vacuum reaches 0.9-1 MPa, turn off the vacuum pump. Then start the mixing motor to mix. First, mix at 900-1000 rpm for 5 minutes, then mix at 400-500 rpm for 2 minutes, and finally mix at 900-1000 rpm for 2 minutes to end the entire mixing process.

[0021] S7: Open the evacuation valve. After the vacuum is removed, raise the sealing cover of the vacuum mixer and pour the mixed raw material into the feed hopper of the coating machine. Adjust the coating thickness and width according to the required specifications, and then start the machine to produce cold compresses.

[0022] S8: The finished cold compress patches should be placed on a drying rack to air dry naturally, or directly packaged in a packaging bag. The drying time should be controlled within 5-7 hours, followed by random sampling. The sampling indicators are the moisture content in the hydrogel of the cold compress patch, or the residue of the hydrogel after the cold compress patch is applied to human skin. If there is no residue after the cold compress patch is removed, the product is qualified.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] A cold compress that can be packaged online includes a base layer and a sealing layer. The edges of the base layer and the sealing layer are heat-sealed to form an adhesive ring. A storage space is formed inside the adhesive ring, and a gel layer is provided inside. A separation gap is formed at the outer edge of the adhesive ring.

[0025] Furthermore, the sealing layer is made of a transparent material.

[0026] Furthermore, the sealing layer is made of a mixture of cast polypropylene film and oriented polypropylene film.

[0027] Furthermore, the base layer is provided with ear loops on both sides.

[0028] This invention improves the formulation and preparation process, reducing the amount of glycerin used while maintaining the water-locking effect of the hydrogel, thereby lowering the material cost of the cold compress. In terms of the product structure, the edges of the substrate layer and the sealing layer are heat-sealed together, forming an adhesive ring. The inner area of ​​this adhesive ring forms a sealed storage space that can hold the fluid gel layer structure. The gel layer is locked within the sealed space formed by the base layer, sealing layer, and edge sealing, preventing gel spillage and eliminating the need for drying and curing, reducing storage space and effectively locking in the moisture of the gel. It also allows for online bagging, reducing product processing steps and increasing delivery speed. A small gap is formed on the outer side of the adhesive ring to facilitate the separation of the sealing layer from the substrate layer. Attached Figure Description

[0029] The present invention will be further described below with reference to the accompanying drawings:

[0030] Figure 1 This is a schematic diagram of the structure of a cold compress patch that can be bagged online according to the present invention;

[0031] Figure 2 This is a schematic diagram of the structure of a cold compress patch that can be bagged online according to the present invention;

[0032] Figure 3 for Figure 2 A cross-sectional view along the center line at point “AA”;

[0033] Figure 4 for Figure 3 Enlarged view of point B in the middle. Detailed Implementation

[0034] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0035] This invention proposes a formula for an online-packaged cold compress patch. By changing the material ratio and preparation process, the water-locking ability of the cold compress patch is improved, thereby extending the effective duration of the cold compress patch.

[0036] Example 1:

[0037] The specific material composition is as follows:

[0038] Oil raw materials:

[0039]

[0040] Water-based raw materials:

[0041]

[0042] The specific preparation steps are as follows:

[0043] S1: Dissolve 0.6 g potassium sorbate and 0.4 g g glucomannan in 4000 g purified water, and dissolve 13.2 g tartaric acid in 1140 g purified water. Then mix the two solutions and stir well before use.

[0044] S2: Take 312g of sodium polyacrylate, 7.8g of aluminum hydroxyl, and 7.2g of disodium salt and mix them evenly in a dry state for later use;

[0045] S3: Place 500g of glycerin in the emulsifier tank, add the mixture obtained in S2 into the emulsifier tank, start the emulsifier and emulsify for 5-6 minutes, then set aside.

[0046] S4: Take 30 grams of cooling agent, dissolve it in 60 grams of ethanol, then pour the mixed solution into a mixing bowl, stir well and set aside.

[0047] S5: Pour the mixed solution and emulsion obtained in steps S1, S3 and S4 into a vacuum stirring tank and cover it with a sealed lid;

[0048] S6: Turn on the vacuum pump to evacuate the vacuum mixing tank. When the vacuum reaches 0.9-1 MPa, turn off the vacuum pump. Then start the mixing motor to mix. First, mix at 900-1000 rpm for 5 minutes, then mix at 400-500 rpm for 2 minutes, and finally mix at 900-1000 rpm for 2 minutes to end the entire mixing process.

[0049] S7: Open the evacuation valve. After the vacuum is removed, raise the sealing cover of the vacuum mixer and pour the mixed raw material into the feed hopper of the coating machine. Adjust the coating thickness and width according to the required specifications, and then start the machine to produce cold compresses.

[0050] S8: The finished cold compress patches should be placed on a drying rack to air dry naturally, or directly packaged in a packaging bag. The drying time should be controlled within 5-7 hours, followed by random sampling. The sampling indicators are the moisture content in the hydrogel of the cold compress patch, or the residue of the hydrogel after the cold compress patch is applied to human skin. If there is no residue after the cold compress patch is removed, the product is qualified.

[0051] Example 2:

[0052] The specific material composition is as follows:

[0053] Oil raw materials:

[0054]

[0055] Water-based raw materials:

[0056]

[0057] The specific preparation steps are as follows:

[0058] S1: Dissolve 0.6 g potassium sorbate and 0.4 g g glucomannan in 4000 g purified water, and dissolve 13.2 g tartaric acid in 1140 g purified water. Then mix the two solutions and stir well before use.

[0059] S2: Take 350g of sodium polyacrylate, 9g of aluminum hydroxyl, and 7g of disodium salt and mix them evenly in a dry state for later use.

[0060] S3: Place 400g of glycerin in the emulsifier tank, add the mixture obtained in S2 to the emulsifier tank, start the emulsifier and emulsify for 5-6 minutes, then set aside.

[0061] S4: Take 30 grams of cooling agent, dissolve it in 60 grams of ethanol, then pour the mixed solution into a mixing bowl, stir well and set aside.

[0062] S5: Pour the mixed solution and emulsion obtained in steps S1, S3 and S4 into a vacuum stirring tank and cover it with a sealed lid;

[0063] S6: Turn on the vacuum pump to evacuate the vacuum mixing tank. When the vacuum reaches 0.9-1 MPa, turn off the vacuum pump. Then start the mixing motor to mix. First, mix at 900-1000 rpm for 5 minutes, then mix at 400-500 rpm for 2 minutes, and finally mix at 900-1000 rpm for 2 minutes to end the entire mixing process.

[0064] S7: Open the evacuation valve. After the vacuum is removed, raise the sealing cover of the vacuum mixer and pour the mixed raw material into the feed hopper of the coating machine. Adjust the coating thickness and width according to the required specifications, and then start the machine to produce cold compresses.

[0065] S8: The finished cold compress patches should be placed on a drying rack to air dry naturally, or directly packaged in a packaging bag. The drying time should be controlled within 5-7 hours, followed by random sampling. The sampling indicators are the moisture content in the hydrogel of the cold compress patch, or the residue of the hydrogel after the cold compress patch is applied to human skin. If there is no residue after the cold compress patch is removed, the product is qualified.

[0066] Additionally, the production process of the coating machine includes: ① applying hydrogel to achieve a predetermined thickness → ② molding to form a regular shape of the hydrogel on the base fabric → ③ heat sealing to fix the protective layer to the base fabric, with the hydrogel fixed between the protective layer and the base fabric → ④ shaping to cut the cold compress into individual pieces using a cutter.

[0067] See Figure 1-4 In this invention, a cold compress that can be packaged online includes a base layer 1 and a sealing layer 2. The edges of the base layer 1 and the sealing layer 2 are heat-sealed to form an adhesive ring 12. The inner side of the adhesive ring 12 forms a storage space and contains a gel layer 4. The outer edge of the adhesive ring 12 forms a separation gap 10. The base layer 1 and the sealing layer 2 form the main structure of the cold compress. The edges of the surfaces that meet each other are heat-sealed to form an adhesive ring 12, so that the interior of the base layer 1 and the sealing layer 2 inside the adhesive ring 12 forms a sealed space to store the fluid gel layer 4. The outer edge of the adhesive ring 12, that is, between the base layer 1 and the sealing layer 2, forms a separation gap 10 to facilitate the removal of the sealing layer 2.

[0068] Specifically, the sealing layer 2 is made of a transparent material, which facilitates observation of the fluidity of the gel inside. For example, it is made of a mixture of oriented polypropylene film and cast polypropylene film. The oriented polypropylene film (OPP) has high strength and high transparency, which can reduce the chance of breakage and make it easy to observe the state of the gel. The cast polypropylene film (CPP) has high toughness and high tear resistance. When the sealing layer made of the two is torn and separated from the base layer 1, it will not leave the adhesive ring 12 marks, which is convenient for use.

[0069] Specifically, the base layer 1 is provided with ear loops 3 on both sides. When the cold compress is used as an eye patch, the ear loops on both sides can be hung on the user's ears for easy use.

[0070] The above description is only a preferred embodiment of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions that fall within the scope of the present invention are within the scope of protection of the present invention.

Claims

1. A cold compress that can be packaged online, comprising a substrate layer (1) and a sealing layer (2), characterized in that, The substrate layer (1) and the sealing layer (2) are heat-sealed to form an adhesive ring (12). The inner side of the adhesive ring (12) forms a storage space and is provided with a hydrogel layer (4). The outer edge of the adhesive ring (12) forms a separation gap (10).

2. The online-packageable cold compress according to claim 1, characterized in that, The sealing layer (2) is made of a transparent material.

3. A cold compress patch that can be bagged online according to claim 1 or 2, characterized in that, The sealing layer (2) is made of a mixture of cast polypropylene film and oriented polypropylene film.

4. A cold compress patch that can be bagged online according to claim 3, characterized in that, The base layer (1) is provided with ear loops (3) on both sides.

5. A formula for a cold compress patch that can be packaged online, characterized in that: Including the following raw materials Oil raw materials: Water-based raw materials:

6. A preparation process for a cold compress patch that can be bagged online, characterized in that... The cold compress is prepared using the formula described in claim 5, and the specific steps are as follows: S1: Dissolve 0.6 g potassium sorbate and 0.4 g g glucomannan in 4000 g purified water, and dissolve 13.2 g tartaric acid in 1140 g purified water. Then mix the two solutions and stir well before use. S2: Take 312g of sodium polyacrylate, 7.8g of aluminum hydroxyl, and 7.2g of disodium salt and mix them evenly in a dry state for later use; S3: Place 500g of glycerin in the emulsifier tank, add the mixture obtained in S2 into the emulsifier tank, start the emulsifier and emulsify for 5-6 minutes, then set aside. S4: Take 30 grams of cooling agent, dissolve it in 60 grams of ethanol, then pour the mixed solution into a mixing bowl, stir well and set aside. S5: Pour the mixed solution and emulsion obtained in steps S1, S3 and S4 into a vacuum stirring tank and cover it with a sealed lid; S6: Turn on the vacuum pump to evacuate the vacuum mixing tank. When the vacuum reaches 0.9-1 MPa, turn off the vacuum pump. Then start the mixing motor to mix. First, mix at 900-1000 rpm for 5 minutes, then mix at 400-500 rpm for 2 minutes, and finally mix at 900-1000 rpm for 2 minutes to end the entire mixing process. S7: Open the evacuation valve. After the vacuum is removed, raise the sealing cover of the vacuum mixer and pour the mixed raw material into the feed hopper of the coating machine. Adjust the coating thickness and width according to the required specifications, and then start the machine to produce cold compresses. S8: The finished cold compress patches should be placed on a drying rack to air dry naturally, or directly packaged in a packaging bag. The drying time should be controlled within 5-7 hours, followed by random sampling. The sampling indicators are the moisture content in the hydrogel of the cold compress patch, or the residue of the hydrogel after the cold compress patch is applied to human skin. If there is no residue after the cold compress patch is removed, the product is qualified.

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