A 5'utr sequence and its application in improving the efficiency of mrna translation

By designing and optimizing 5'-UTR elements and constructs, the problem of insufficient mRNA translation efficiency was solved, resulting in more efficient mRNA drug expression and stability, and improving the efficacy of tumor therapeutic mRNA vaccines.

CN121022837BActive Publication Date: 2026-05-26BEIJING IMMUPEUTICS MEDICINE TECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING IMMUPEUTICS MEDICINE TECH LTD
Filing Date
2025-02-06
Publication Date
2026-05-26

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Abstract

This invention discloses a 5'UTR sequence and its application in improving mRNA translation efficiency. This invention belongs to the field of biotechnology. The 5'UTR sequence designed in this invention has excellent function in promoting mRNA expression. Compared with the commonly used HBA1 gene 5'UTR, the expression level of FLuc mRNA fused with the 5'UTR in this invention can be increased by 2 to 3.5 times.
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Citation Information

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