An oleandros oligosaccharide, a preparation method and application thereof
Oleander oligosaccharide with a molecular weight of 2970 Da was prepared by water extraction, alcohol precipitation and multi-stage membrane separation technology, which solved the problems of unclear structure and complicated purification steps in the existing technology, and achieved efficient purification and immune enhancement effect.
CN121045409BActive Publication Date: 2026-06-30INSTITUTE OF TCM HEALTH INDUSTRY CACMS
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INSTITUTE OF TCM HEALTH INDUSTRY CACMS
- Filing Date
- 2025-11-05
- Publication Date
- 2026-06-30
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Figure CN121045409B_ABST
Abstract
This invention belongs to the field of pharmaceutical technology and discloses an oleander oligosaccharide, its preparation method, and its applications. The oleander oligosaccharide has a molecular weight of 2970 Da and is composed of glucose, mannose, galactose, and arabinose. The method involves first defatting oleander roots with ethanol, followed by water extraction and sequential alcohol extraction at varying concentrations. The alcohol extracts are then enriched by ceramic membrane-ultrafiltration-nanofiltration, purified by ion exchange column chromatography, and purified by molecular sieve gel column chromatography. This oligosaccharide can be used in the preparation of immune-enhancing drugs, corresponding tumor immunotherapy drugs, or health products. The preparation method of this invention is efficient and safe, yielding a high-quality product suitable for the preparation of tumor immunotherapy drugs.
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