Liquid medicine mixing and shaking mechanism and liquid medicine mixing and shaking system

Abstract

The invention relates to a liquid medicine mixing and shaking mechanism and a liquid medicine mixing and shaking system, and belongs to the technical field of automatic pharmaceutical equipment. The medicine liquid mixing and shaking mechanism comprises a driving assembly, a bearing plate and a springback assembly. And the driving assembly is connected with the medicine bottle mounting device and can do vertical reciprocating motion on the bearing plate under the constraint of the springback assembly. The liquid medicine mixing and shaking-up system comprises a plurality of liquid medicine mixing and shaking-up mechanisms, a conveying chain used for bearing and conveying the mechanisms to a preset shaking-up station, and a fixed driving source located at the shaking-up station and used for driving the driving assembly. The driving assembly drives the medicine bottle to do high-frequency vertical reciprocating motion, so that liquid in the bottle generates strong impact and turbulent flow, the problems that an existing horizontal shaking mode is prone to generating vortex and uneven in mixing are effectively solved, the uniformity and efficiency of medicine liquid mixing are remarkably improved, and automatic assembly line work is achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of automatic pharmaceutical equipment, and in particular to a liquid medicine mixing and shaking mechanism and a liquid medicine mixing and shaking system. BACKGROUND

[0002] Currently, in the medical or pharmaceutical industry, many medicines (such as freeze-dried powder injections) need to be mixed with solvent and medicine powder before use. The traditional preparation process often relies on manual operation, for example, manually injecting solvent into a Westlin bottle, and then manually shaking to fully dissolve the medicine powder.

[0003] This manual method has several shortcomings. First, the force, frequency and time of manual shaking are difficult to standardize, and the shaking actions of different operators, or even the same person at different times, are different, which can lead to insufficient dissolution or uneven mixing of the medicine powder, affecting the concentration and efficacy of the final liquid medicine. Second, manual preparation is low in efficiency and difficult to meet the needs of large-scale production or centralized medicine preparation. In addition, the manual operation process also increases the risk of exposure of the liquid medicine to the external environment, which may introduce contamination.

[0004] To solve the above problems, some automatic shaking devices have appeared. However, the existing automatic devices mostly use horizontal rotation or track shaking. This horizontal shaking method is prone to generating vortex effect in the medicine bottle, causing the medicine powder to only rotate with the liquid and not being fully wetted and dispersed, especially for some medicine powder attached to the bottom of the bottle or clumped, the mixing effect is poor. In addition, this rotational motion has limited effect on impacting and dispersing stubborn particles.

[0005] The main defect of the related art is that the liquid medicine mixing uniformity is poor due to the randomness of manual shaking and the vortex effect generated by automatic horizontal shaking. SUMMARY

[0006] The present application aims to improve the problem of poor liquid medicine mixing uniformity caused by the randomness of manual shaking or the vortex effect generated by automatic horizontal shaking, and provides a liquid medicine mixing and shaking mechanism and a liquid medicine mixing and shaking system.

[0007] The liquid medicine mixing and shaking mechanism provided by the present application adopts the following technical solution: A liquid medicine mixing and shaking mechanism, comprising: a driving assembly, a bearing plate and a rebound assembly, the driving assembly is configured to be connected with a medicine bottle mounting device and is used to drive the medicine bottle mounting device to make reciprocating motion in the vertical direction; the bearing plate is movably connected with the driving assembly, and the driving assembly can move relative to the bearing plate; the rebound assembly is connected between the driving assembly and the bearing plate, and the rebound assembly is used to provide a restoring force for the driving assembly.

[0008] By adopting the technical scheme, the driving, mounting and rebound components are integrated into an independent module capable of generating high-frequency vertical impact motion, the up-and-down violent impact and turbulent flow effect of liquid are utilized, the vortex problem of horizontal shaking is effectively overcome, the bottle bottom medicine powder can be quickly wetted and dispersed, and the uniformity and efficiency of mixing are significantly improved.

[0009] Optionally, the driving assembly comprises a driven plate connected with the medicine bottle mounting device, and a driving plate connected with the driven plate, the driving plate being configured to be driven by an external driving source and driving the driven plate to move.

[0010] By adopting the technical scheme, the functions of the driving assembly are split, the driving plate is used to receive external driving force, and the driven plate is used to carry the medicine bottle, so that the structure functions are clear, and the reliability of movement is improved.

[0011] Optionally, the rebound assembly is a spring for providing the reset force.

[0012] By adopting the technical scheme, the spring is used as the rebound component, which has simple structure, low cost and stable performance, and is an economical and reliable implementation manner.

[0013] Optionally, the rebound assembly comprises a driving plate rebound component and a driven plate rebound component, the driving plate rebound component being connected with the driving plate and the carrying plate, and the driven plate rebound component being connected with the driven plate and the carrying plate.

[0014] By adopting the technical scheme, the rebound force is provided for the driving plate and the driven plate respectively, so that the overall movement of the driving assembly is more stable and controlled, unnecessary vibration is inhibited, and the stability of the shaking operation is improved.

[0015] Optionally, a magnet is arranged on the driving plate.

[0016] By adopting the technical scheme, the magnet is arranged, so that the medicine liquid mixing and shaking mechanism can cooperate with an external electromagnetic driving source to realize non-contact driving, which has fast response, small wear and high cleanliness.

[0017] Optionally, a limiting device is further arranged between the carrying plate and the driving plate, for limiting the movement range of the driving plate.

[0018] By adopting the technical scheme, the limiting device can effectively constrain the maximum stroke of the driving plate, which helps to reduce the damage of components caused by abnormal driving, and improves the durability of the mechanism.

[0019] The medicine liquid mixing and shaking system provided in the application adopts the following technical scheme: A medicine liquid mixing and shaking system, comprising: The medicine liquid mixing and shaking mechanism as any one of the preceding claims, a medicine bottle mounting device connected to the driving assembly of the medicine liquid mixing and shaking mechanism, and an equipment support provided with a conveying chain and a driving source; the conveying chain is used to carry and convey the shaking mechanism and is provided with a preset shaking station; the driving source is located at the shaking station and is used to drive the shaking mechanism.

[0020] By adopting the above technical scheme, the plurality of shaking mechanisms are carried on the conveying chain and are driven at the fixed station, realizing the flow line operation of the shaking process, saving the repeated grabbing and transferring of materials, and helping to greatly improve the overall preparation efficiency.

[0021] Optionally, the external driving source is a voice coil motor.

[0022] By adopting the above technical scheme, the voice coil motor can provide high-frequency and accurate linear driving force, facilitating accurate control of the amplitude and frequency of shaking to adapt to the mixing needs of different medicines, and improving the universality of the scheme.

[0023] Optionally, the medicine liquid mixing and shaking system further comprises a limiting pressing piece, the limiting pressing piece is arranged on the equipment support and located at the shaking station; the carrying plate is provided with a limiting groove matched with the limiting pressing piece; the limiting pressing piece is configured to be pressed into the limiting groove at the shaking station.

[0024] By adopting the above technical scheme, the limiting pressing piece and the limiting groove cooperate at the shaking station to accurately position the carrying plate moving with the chain. This design helps to overcome the positioning error that may exist in the conveying chain itself, ensures the high consistency of the relative position between the shaking mechanism and the driving source, and thus provides a strong guarantee for obtaining uniform and reliable shaking effect.

[0025] Optionally, the limiting pressing piece comprises a resilient component, and the limiting pressing piece is connected to the equipment support through the resilient component.

[0026] By adopting the above technical scheme, the limiting pressing piece is added with elasticity, so that it can be flexibly pressed into the limiting groove. This helps to absorb impact and compensate for small deviations, making the positioning process more smooth and reliable.

[0027] In summary, the present application includes at least one of the following beneficial technical effects: 1. The application provides a modular liquid mixing and shaking mechanism, which integrates a driving assembly, a bearing plate and a rebound assembly to form a standard unit capable of generating stable and repeatable vertical reciprocating motion. The up-and-down impact and turbulent flow of liquid effectively solve the vortex problem of horizontal shaking, enabling faster and more sufficient mixing of liquid medicine, significantly improving the uniformity and consistency between batches, and realizing automated operation and improved preparation efficiency.

[0028] 2. By cooperating the limiting pressure piece with the limiting groove, the bearing plate can be effectively locked during shaking to prevent it from following vibration, thereby ensuring the stability of the shaking action and the uniformity of the shaking effect. 3. Preferably, a non-contact driving method of magnet and voice coil motor is adopted, which has the advantages of precise control, fast response, high cleanliness, etc., enhancing the adaptability of the scheme to different medicine mixing requirements.

[0029] 4. By adding a rebound component to the limiting pressure piece, the positioning process is smoother and softer, which helps to improve the long-term operation stability and durability of the system. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 is a first view schematic diagram of the liquid mixing and shaking system structure of the embodiment of the application.

[0031] Figure 2 is a second view schematic diagram of the liquid mixing and shaking system structure of the embodiment of the application.

[0032] Figure 3 is a front view of the liquid mixing and shaking mechanism of the embodiment of the application. Figure 1 .

[0033] Figure 4 is a front view of the liquid mixing and shaking mechanism of the embodiment of the application. Figure 2 .

[0034] Figure 5 is a structural schematic diagram of the liquid mixing and shaking system structure of the embodiment of the application.

[0035] Figure 6 is a local enlarged schematic diagram of the A area of Figure 5 .

[0036] Figure 7 is a structural schematic diagram of the bearing plate and the equipment support in the liquid mixing and shaking system of the embodiment of the application. Figure 1 .

[0037] Figure 8 is a structural schematic diagram of the bearing plate and the equipment support in the liquid mixing and shaking system of the embodiment of the application. Figure 2 .

[0038] Reference numerals: 10, drive assembly; 11, drive plate; 11a, magnet; 12, driven plate; 20, rebound assembly; 21, drive plate rebound; 22, driven plate rebound; 30, bearing plate; 31, limiting groove; 40, connecting rod; 41, limiting device; 50, medicine bottle mounting device; 60, equipment support; 61, transportation chain; 62, driving source; 63, limiting pressing piece. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solutions and advantages of the present application clearer, the following will combine the drawings to further describe the present application. Figures 1-8 The embodiments of the present application will be further described in detail. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0040] The core idea of the embodiments of the present application is to design a modularized mechanism for shaking evenly through vertical reciprocating motion, and integrate it into an automatic assembly line system, so as to solve the problem of uneven mixing caused by improper shaking in the prior art.

[0041] The present embodiment discloses a medicine liquid mixing and shaking mechanism, which is a core functional unit for realizing efficient mixing.

[0042] Referring to Figure 1 and Figure 2 , the two figures respectively show the overall three-dimensional structure of the medicine liquid mixing and shaking mechanism with the medicine bottle mounting device 50 installed. Figure 1 The right front isometric view of the combined structure is presented. From this view, it can be observed that the medicine liquid mixing and shaking mechanism presents as an integrated modularized unit, the main components of which include the drive assembly 10 for performing vertical motion and the bearing plate 30 as the installation base. The top (the detailed position corresponds to the Figure 1 or Figure 2 The driven plate 12 in the driven plate 12) is provided with a medicine bottle mounting device 50 for detachably holding a medicine bottle. The internal hierarchical structure of the drive assembly 10 is also presented, which includes the upper driven plate 12 and the lower drive plate 11, and the magnet 11a is arranged on the upper surface of the drive plate 11. In the present embodiment, the driven plate 12 and the drive plate 11 are fixedly connected through the connecting rod 40. Figure 2 Then a right front bottom view angle is provided, which further illustrates the spatial arrangement and connection relationship between the components of the combined structure of the medicine liquid mixing and shaking mechanism with the medicine bottle mounting device 50 installed. Figure 2It can be clearly seen that the driving plate 11 is fixedly connected with the driven plate 12, and both are movably installed in the space defined by the carrier plate 30. In this embodiment, a resilient assembly 20 is arranged between the driving plate 11 and the carrier plate 30 (in fact, the resilient assembly 20 is not only used here, refer to Figure 3 As can be seen, the resilient assembly 20 includes a driving plate resilient member 21 between the driving plate 11 and the carrier plate 30, and a driven plate resilient member 22 between the driven plate 12 and the carrier plate 30, and the limiting device 41 is arranged between the driving plate 11 and the carrier plate 30, which together constitute the movement and constraint system of the liquid mixing and shaking mechanism.

[0043] Referring to Figure 3 and Figure 4 , both of which are cross-sectional views of the liquid mixing and shaking mechanism, showing the structural configuration of the mechanism in two different working states.

[0044] Figure 3 The structural configuration of the liquid mixing and shaking mechanism in the static or initial state is described in detail, when the external driving force has not been applied. The structure of the liquid mixing and shaking mechanism is built on the carrier plate 30, which not only serves as a rigid base, but also provides a reference for the installation and movement of other movable parts. The driving assembly 10 (i.e. Figure 3The driving plate 11 and the driven plate 12 are movably mounted on the bearing plate 30, and in this embodiment, the connecting rod 40 connecting the driving plate 11 and the driven plate 12 penetrates the bearing plate 30. The driving assembly 10 is rigidly connected by the driving plate 11 and the driven plate 12 in a vertical stack. The driving plate 11 is located below, and in this embodiment, a magnet 11a is fixedly arranged at the center of the upper surface of the driving plate 11, which is used to generate a coupling force with an external electromagnetic driving source. The driven plate 12 is located above the driving plate 11 and moves synchronously with the driving plate 11, and the upper end of the driven plate 12 is used to connect the medicine bottle mounting device 50. To achieve reciprocating motion, a rebound assembly 20 is arranged in the mechanism, and in this embodiment, the rebound assembly 20 is cooperatively worked by two springs: one is a driving plate rebound member 21 (such as a tensile spring) connected between the bearing plate 30 and the driving plate 11, which is used to provide an upward restoring tension; the other is a driven plate rebound member 22 (such as a compression spring) arranged between the bearing plate 30 and the lower surface of the driven plate 12, which is used to provide an upward restoring thrust. In addition, to prevent the driving assembly 10 from being damaged due to excessive travel, a limiting device 41 is further arranged on the bearing plate 30, which in this embodiment is represented by a plurality of limiting columns arranged below the driving plate 11 to limit the maximum downward displacement of the driving plate 11, which helps to reduce the risk of damage caused by excessive stretching or compression of the rebound assembly 20 due to excessive travel, and also protects the structure of the driving assembly 10 itself, thereby improving the durability and reliability of the mechanism.

[0045] Figure 4 The structure of the medicine liquid mixing and uniform shaking mechanism in the driven state is shown. Compared with the initial state shown in Figure 3 When the external driving source below the mechanism is started and generates a downward magnetic attraction force, the force acts on the magnet 11a, and the entire driving assembly 10 is driven to move downward against the resistance of the rebound assembly 20, until the lower surface of the driving plate 11 abuts against the limiting device 41. At this limit position, the driving plate rebound member 21 is stretched to the maximum length, and the driven plate rebound member 22 is compressed to the minimum length, and both the driving plate rebound member 21 and the driven plate rebound member 22 store significant elastic potential energy.

[0046] The implementation principle of embodiment 1 is that the working principle of the medicine liquid mixing and uniform shaking mechanism is based on the precise cooperation of external driving force and internal restoring force, and the efficient conversion between kinetic energy and potential energy. In the initial state shown in Figure 3The pre-set force of the driving plate spring 21 and the driven plate spring 22 together keep the driving assembly 10 in a stable initial position. When the external driving source is activated and driving force is applied (as shown in state Figure 4 When the external driving force is weakened or removed, the stored elastic potential energy is immediately released, jointly pushing the driving assembly 10 to rebound upward at a high acceleration. By periodically applying and removing the driving force at a set high frequency through the external driving source, the driving assembly 10 will drive the medicine bottle installation device 50 and the medicine bottle mounted thereon to stably and violently vibrate vertically and reciprocally at a high frequency, so that the liquid in the bottle generates strong impact and turbulence under the action of inertia, thereby achieving rapid and sufficient mixing of the liquid.

[0047] The present application also discloses an automatic system integrated with the above-mentioned liquid mixing and shaking mechanism.

[0048] Referring to Figure 5 , the figure is a schematic diagram of the overall structure of the liquid mixing and shaking system. The entire system is built on a solid equipment support 60. A transport chain 61 serves as a conveying device and runs through the predetermined path of the equipment support 60. A plurality of the aforementioned liquid mixing and shaking mechanisms are fixedly installed on the transport chain 61, and a medicine bottle installation device 50 is installed on the driving assembly 10 of each liquid mixing and shaking mechanism. When the transport chain 61 runs, the liquid mixing and shaking mechanisms will move with the chain to transport the medicine bottles loaded in the medicine bottle installation devices 50 from one station to the next. The A area shown in the figure is defined as the shaking station of the system (the precise position of the shaking station is defined by the position of the transport chain 61 when the liquid mixing and shaking mechanism is locked and the shaking operation is performed). Figure 8 As shown in Figure 8 , the liquid mixing and shaking mechanism moves with the transport chain 61 to the locked position, at which the liquid mixing and shaking mechanism is locked and then performs the shaking operation. The position is the precise shaking station in this embodiment).

[0049] For a clearer display of the internal configuration of the shaking station, please refer to Figure 6 , the figure is Figure 5A local enlarged view of region A. This figure shows in detail the interaction of the reagent mixing and shaking mechanism with the external fixture when the reagent mixing and shaking mechanism is being transported to the shaking station. The carrier plate 30 of the reagent mixing and shaking mechanism is stopped right above the station by the transport chain 61, while a non-contact driving source 62 is fixedly installed on the fixture support 60 right below the carrier plate 30. The position of the driving source 62 is accurately corresponding to the driving assembly 10 below the carrier plate 30.

[0050] To further illustrate how the system ensures the stability of operation at the shaking station, please refer to Figure 7 and Figure 8 , which are two figures specifically depicting the precise fitting process of the carrier plate 30 and the fixture support 60 at the shaking station. Figure 7 This figure shows the moment when the carrier plate 30 is moving to the shaking station with the chain but has not been locked yet (in this embodiment, the carrier plate 30 is still in the process of being moved to the shaking station by the transport chain 61). Figure 7 and Figure 8 "locking" or "locking up" both refer to the up-and-down locking, i.e. reducing the up-and-down vibration of the reagent mixing and shaking mechanism. In this embodiment, the limiting pressure piece 63 installed on the fixture support 60 is vertically downward, can rotate around the rotating shaft at one end, and is configured to be able to rotate left and right by being pushed by the reagent mixing and shaking mechanism driven by the transport chain 61. In this embodiment, the limiting pressure piece 63 will rebound to the initial state without external force or external structure restriction. Figure 7 This figure shows the state when the reagent mixing and shaking mechanism is about to move to the shaking station but is not locked yet, and there is still a certain distance between the limiting groove 31 and the limiting pressure piece 63. Figure 8 This figure shows the state after locking is completed. Under the transmission of the transport chain 61, the reagent mixing and shaking mechanism moves horizontally to the limiting pressure piece 63, and the moving end part of the limiting pressure piece 63 is accurately clamped into the limiting groove 31. The clamping of the limiting pressure piece 63 into the limiting groove 31 forms a reliable mechanical connection between the carrier plate 30 and the stationary fixture support 60, effectively inhibiting the shaking of the reagent mixing and shaking mechanism caused by the transmission gap or vibration of the transport chain itself, providing a stable reference for subsequent high-frequency shaking operation, which enables the driving energy to be more mainly used for generating effective vertical vibration, reduces unnecessary energy dissipation, and thus is conducive to improving the uniformity of shaking effect. In this embodiment, the limiting pressure piece 63 can be connected to the fixture support 60 through a rebound component, so that the limiting pressure piece 63 moves more gently when clamping into and out of the limiting groove 31, can absorb impact and compensate for small positioning errors, and can reset the limiting pressure plate 63.

[0051] The implementation principle of the medicine liquid mixing and shaking system is a serialized automatic operation process. In the initial stage, the medicine bottle containing the medicine liquid to be mixed is placed in the medicine bottle mounting device 50 mounted on the medicine liquid mixing and shaking mechanism in the upstream work station. Then, the transport chain 61 is activated to move the medicine liquid mixing and shaking mechanism stably to the preset shaking work station. When the medicine liquid mixing and shaking mechanism reaches the specified position (as shown in the state of Figure 8 ), the transport chain 61 stops moving, at this time, the limiting pressing piece 63 is clamped into the limiting groove 31 of the bearing plate 30, thereby stably locking the base of the medicine liquid mixing and shaking mechanism (i.e. the bearing plate 30) on the equipment support 60 (as shown in the state of Figure 8 ). On this stable basis, the controller starts the driving source 62 located below, the high-frequency driving force generated by the driving source 62 acts on the driving plate 11 in a non-contact manner, drives the entire driving assembly 10 and the medicine bottle mounting device 50 mounted on the driving assembly 10 to perform violent vertical reciprocating motion, thereby realizing rapid mixing of the medicine liquid. After reaching the preset shaking time, the driving source 62 stops working, the transport chain 61 is started again, the medicine liquid mixing and shaking mechanism continues to move, the limiting pressing piece 63 is withdrawn from the limiting groove 31, the locking of the bearing plate 30 is released, the medicine bottle after mixing is sent to the downstream work station for subsequent processing, and the next medicine liquid mixing and shaking mechanism to be processed is transported to the shaking work station. This process is repeated, forming a continuous, efficient and automatic medicine liquid preparation process.

[0052] The above are preferred embodiments of the present application, and do not limit the protection scope of the present application, therefore: any equivalent changes made according to the structure, shape, principle of the present application should be covered within the protection scope of the present application.

Claims

1. A mechanism for mixing and shaking a medicinal solution, characterized in that, include: A drive assembly (10) is used to connect to a vial mounting device (50) and drive the vial mounting device (50) to reciprocate in the vertical direction; The support plate (30) is movably connected to the drive assembly (10), and the drive assembly (10) can move relative to the support plate (30); A springback assembly (20) is connected between the drive assembly (10) and the support plate (30) to provide a restoring force to the drive assembly (10).

2. The liquid mixing and shaking mechanism according to claim 1, characterized in that, The drive assembly (10) includes: a driven plate (12) for connection to the vial mounting device (50); and a drive plate (11) for connection to the driven plate (12), the drive plate (11) being configured to be driven by an external drive source (62) and to move the driven plate (12).

3. The liquid mixing and shaking mechanism according to claim 2, characterized in that, The spring-loaded assembly (20) is a spring used to provide the restoring force.

4. The liquid mixing and shaking mechanism according to claim 2 or 3, characterized in that, The springback assembly (20) includes a drive plate springback component (21) and a driven plate springback component (22); the drive plate springback component (21) is connected to the drive plate (11) and the support plate (30); the driven plate springback component (22) is connected to the driven plate (12) and the support plate (30).

5. The liquid mixing and shaking mechanism according to claim 2, characterized in that, A magnet (11a) is provided on the drive board (11).

6. The liquid mixing and shaking mechanism according to claim 2, characterized in that, It also includes a limiting device (41), which is disposed between the support plate (30) and the drive plate (11) to limit the range of motion of the drive plate (11).

7. A system for mixing and shaking a pharmaceutical solution, characterized in that, include: The liquid mixing and shaking mechanism as described in any one of claims 1-6; A medicine bottle mounting device (50) is connected to the drive assembly (10) of the medicine liquid mixing and shaking mechanism and is used to mount medicine bottles. The equipment support (60) is provided with a transport chain (61) and a drive source (62); the transport chain (61) is configured to carry and transport the support plate (30) of the liquid mixing and shaking mechanism, and the transport chain (61) is provided with a preset shaking station; the drive source (62) is located at the preset shaking station and is used to drive the drive component (10) of the liquid mixing and shaking mechanism.

8. The pharmaceutical solution mixing and shaking system according to claim 7, characterized in that, The drive source (62) is a voice coil motor.

9. The pharmaceutical solution mixing and shaking system according to claim 7 or 8, characterized in that, It also includes a limiting pressure member (63), which is disposed on the equipment bracket (60) and located at the shaking station; the bearing plate (30) has a limiting groove (31) that matches the limiting pressure member (63); the limiting pressure member (63) is configured to press into the limiting groove (31) at the shaking station.

10. The pharmaceutical solution mixing and shaking system according to claim 9, characterized in that, The limiting pressure member (63) includes a spring-back component, and the limiting pressure member (63) is connected to the equipment bracket (60) through the spring-back component.

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