Red blood cell activity maintaining device for nanometer engineering

Abstract

The invention discloses a erythrocyte activity keeping device for nanometer engineering, and relates to the technical field of erythrocyte activity keeping, the erythrocyte activity keeping device comprises a box body, a rotating assembly, a storage basket, a controller and a temperature control assembly, the upper surface of the box body is provided with a door body, the front side of the box body is provided with a front side plate, and a storage cavity is formed between the box body and the front side plate; and a rotating hole is formed in the front side plate. The rotating assembly is rotationally installed in the containing cavity. The controller controls the temperature control assembly to preset the temperature range (such as 1-6 DEG C) suitable for red blood cell preservation, the door body is arranged, when the door body is opened, the red blood cell bag can be placed into the containing cavity or taken out of the containing cavity, when the door body is opened, the lower end of the door body makes contact with the containing basket, the leakproofness is improved, and the storage efficiency is improved. And the problem that the activity of other red blood cells is reduced due to the change of the internal temperature when the red blood cells are frequently taken or stored is avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of red blood cell activity maintenance, and particularly relates to a red blood cell activity maintenance device for nanotechnology. BACKGROUND

[0002] The red blood cell is very small in volume, with a diameter of only 7-8 mu m, like a disc, with a concave middle and a thick edge, like a round cake. It has elasticity and plasticity, and must pass through alone when passing through a capillary with a diameter of 10 mu m, which is beneficial to the exchange of substances.

[0003] Standard in vitro liquid preservation (1-6 DEG C + special anticoagulant preservation solution) is still the most commonly used and most mature and reliable method for maintaining red blood cell activity, and the preservation period can reach several weeks. The existing red blood cell activity maintenance device will cause the internal temperature to change when frequently taken out or stored, resulting in a decrease in the activity of the remaining red blood cells. SUMMARY

[0004] The embodiment of the present application provides a red blood cell activity maintenance device for nanotechnology, which aims to solve the problem that the internal temperature changes when frequently taken out or stored, resulting in a decrease in the activity of the remaining red blood cells.

[0005] In order to achieve the above-mentioned purpose, the embodiment of the present application adopts the following technical scheme:

[0006] A red blood cell activity maintenance device for nanotechnology comprises:

[0007] A box body, the upper surface of the box body is provided with a door body, the front side of the box body is provided with a front side plate, a receiving cavity is formed between the box body and the front side plate, and a rotating hole is formed in the front side plate;

[0008] A rotating assembly is rotatably installed in the inside of the receiving cavity, a fixed groove is formed in the inner side wall of the box body for the rotation of one end of the rotating assembly, the other end of the rotating assembly is connected with a rotating disc through the rotating hole, and a locking assembly is arranged between the rotating assembly and the rotating hole;

[0009] A plurality of receiving baskets are annularly distributed on the periphery of the rotating assembly with the rotating assembly as the center, and perform synchronous rotary motion with the rotating assembly, and a connecting piece is arranged between the receiving basket and the rotating assembly;

[0010] A controller is connected with the front side of the front side plate;

[0011] A temperature control assembly is connected with the rear side of the box body, the temperature control assembly is in communication with the receiving cavity, and the temperature control assembly is electrically connected with the controller.

[0012] Further, the rotating assembly comprises:

[0013] A rotating column is transversely rotatably installed inside the receiving cavity.

[0014] A fixed rod has one end connected to one end of the rotating column, and the other end of the fixed rod is rotatably installed in the fixed slot.

[0015] A first connecting rod has one end connected to the other end of the rotating column, and the other end of the first connecting rod passes through the rotating hole and is connected to the rotating disc.

[0016] Further, the locking assembly comprises:

[0017] A round head locking block, the sidewall of the rotating hole is provided with a receiving slot, and the round head locking block is slidably installed in the receiving slot.

[0018] A telescopic spring is located in the receiving slot, one end of the telescopic spring is connected to the inner sidewall of the receiving slot, and the other end of the telescopic spring is connected to the round head locking block.

[0019] A semicircular slot, a plurality of semicircular slots are provided on the outer surface of the first connecting rod, and the round head end of the round head locking block is clamped with the semicircular slot.

[0020] Further, the connecting member comprises:

[0021] A connecting plate, one end of a plurality of connecting plates is connected to the outer surface of the rotating column, and the other end of a plurality of connecting plates is rotatably connected to the side of the receiving basket, and the connecting plate is on the same straight line with the semicircular slot.

[0022] A first gear is provided on the periphery of the fixed rod.

[0023] A second gear is provided on the other side of the receiving basket, and the second gear is engaged with the first gear.

[0024] Further, the temperature control assembly comprises:

[0025] A gas pump;

[0026] An air inlet pipe has one end connected to the gas pump, and the other end of the air inlet pipe passes through the box and communicates with the receiving cavity.

[0027] A condenser, the outer sidewall of the box is provided with a condensing chamber through which the air inlet pipe passes, and the condensing chamber is provided with a condenser.

[0028] An evaporator, the outer sidewall of the box and located on one side of the condensing chamber is provided with an evaporation chamber through which the air inlet pipe passes, and the evaporation chamber is provided with an evaporator.

[0029] An exhaust pipe is connected to the right side of the box and penetrates the storage cavity, and a one-way valve is arranged in the exhaust pipe.

[0030] Further, a box door is arranged in the front side plate on the other side of the rotating disc, and an inner side wall of the box is provided with a temperature detector, which is electrically connected to the controller.

[0031] Further, a sealing plate is arranged on the inner side wall of the top end of the box on the left and right sides of the door body, and the lower end of the sealing plate is in contact with the storage basket.

[0032] Further, the door body and the box are connected by a hinge, a torsion spring is arranged in the hinge, the end of the door body is provided with a first magnet, and a second magnet is arranged on the upper end surface of the storage basket in a transverse position.

[0033] Beneficial effects: the storage cavity in the box is used for storage, when in use, the rotating disc is rotated to drive the rotating assembly to rotate, the locking assembly is positioned and unlocked, the rotating assembly drives the storage basket to rotate, when the storage basket is rotated to the position directly below the door body, the opening of the storage basket is always upward through the connecting piece, the temperature control assembly is controlled by the controller to preset a temperature range suitable for the preservation of red blood cells (such as 1-6℃), the door body is arranged, when the door body is opened, the red blood cell bag can be put into or taken out from the storage cavity, and when the door body is opened, the lower end of the door body is in contact with the storage basket, the sealing property is improved, and when the red blood cells are frequently taken out or stored, the internal temperature is prevented from changing, and the activity of the red blood cells is prevented from decreasing. BRIEF DESCRIPTION OF DRAWINGS

[0034] Figure 1 It is a first perspective view of the present application;

[0035] Figure 2 It is a schematic view of the internal structure of the box in the present application;

[0036] Figure 3 It is a schematic view of the front structure of the rotating assembly and the connecting piece in the present application;

[0037] Figure 4 It is a schematic view of the back structure of the connecting piece in the present application;

[0038] Figure 5 It is a schematic view of the back side of the box in the present application;

[0039] Figure 6 It is a schematic view of the cross-sectional structure of the upper part of the front side plate in the present application;

[0040] 1. Box body, 2. Door, 3. Front panel, 4. Storage cavity, 5. Rotating hole, 6. Rotating assembly, 7. Rotating disc, 8. Locking assembly, 9. Storage basket, 10. Connector, 11. Controller, 12. Temperature control assembly, 13. Rotating column, 14. Fixing rod, 15. First connecting rod, 16. Round head locking block, 17. Storage slot, 18. Telescopic spring, 19. Semi-circular groove, 20. Connecting plate, 21. First gear, 22. Second gear, 23. Air pump, 24. Air inlet pipe, 25. Condensation chamber, 26. Evaporation chamber, 27. Exhaust pipe, 28. Box door, 29. Temperature detector, 30. Sealing plate, 31. First magnet, 32. Second magnet. Detailed Implementation

[0041] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0042] In the description of this invention, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0043] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0044] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0045] according to Figures 1-6As shown, a device for preserving the activity of erythrocytes for nanoengineering includes a housing 1, a rotating assembly 6, storage baskets 9, a controller 11, and a temperature control assembly 12. A door 2 is provided on the upper surface of the housing 1, and a front side plate 3 is provided on the front side of the housing 1. A storage cavity 4 is formed between the housing 1 and the front side plate 3, and a rotating hole 5 is provided inside the front side plate 3. The rotating assembly 6 is rotatably mounted inside the storage cavity 4. A fixing groove is provided on the inner side wall of the housing 1 for one end of the rotating assembly 6 to rotate. The other end of the rotating assembly 6 passes through the rotating hole 5 and is connected to a rotating disk 7. A locking assembly 8 is provided between the rotating assembly 6 and the rotating hole 5. Multiple storage baskets 9 are arranged in a ring around the rotating assembly 6, and rotate synchronously with the rotating assembly 6. A connecting piece 10 is provided between the storage baskets 9 and the rotating assembly 6. The controller 11 is connected to the front side of the front side plate 3. The temperature control component 12 is connected to the rear side of the housing 1, the temperature control component 12 is connected to the storage cavity 4, and the temperature control component 12 is electrically connected to the controller 11.

[0046] In this embodiment, the storage cavity 4 inside the housing 1 is used for storage. When in use, the rotating disk 7 is rotated, which drives the rotating component 6 to rotate. The locking component 8 achieves positioning and unlocking. The rotating component 6 drives the storage basket 9 to rotate. When the storage basket 9 rotates to the bottom of the door 2, the opening of the storage basket 9 is always facing upwards due to the connection 10. The controller 11 controls the temperature control component 12 to preset a suitable temperature range for red blood cell preservation (e.g., 1-6℃). With the door 2, the red blood cell bags can be placed into or taken out of the storage cavity 4 when the door 2 is opened. When the door 2 is opened, the lower end of the door 2 contacts the storage basket 9, which increases the airtightness and avoids the problem of internal temperature changes caused by frequent handling or storage, which would lead to a decrease in the activity of other red blood cells.

[0047] Combination Figure 3 and Figure 4 As shown in the embodiment of this application, the rotating assembly 6 includes a rotating column 13, a fixed rod 14, and a first connecting rod 15. The rotating column 13 is laterally rotatably mounted inside the storage cavity 4. One end of the fixed rod 14 is connected to one end of the rotating column 13, and the other end of the fixed rod 14 is rotatably mounted in a fixing groove. One end of the first connecting rod 15 is connected to the other end of the rotating column 13, and the other end of the first connecting rod 15 passes through the rotating hole 5 and is connected to the rotating disk 7.

[0048] Combination Figure 6As shown in the embodiment of this application, the locking assembly 8 includes a round-headed locking block 16, a telescopic spring 18, and a semi-circular groove 19. A receiving groove 17 is provided on the side wall of the rotating hole 5, and the round-headed locking block 16 is slidably installed within the receiving groove 17. The telescopic spring 18 is located within the receiving groove 17, with one end connected to the inner side wall of the receiving groove 17 and the other end connected to the round-headed locking block 16. Multiple semi-circular grooves 19 are formed on the outer surface of the first connecting rod 15, and the rounded end of the round-headed locking block 16 engages with the semi-circular grooves 19. During rotation, the round-headed locking block 16, under the action of the telescopic spring 18, alternately engages and disengages with the semi-circular grooves 19 on the first connecting rod 15, achieving positioning and unlocking.

[0049] Combination Figure 3 As shown in the embodiment of this application, the connector 10 includes a connecting plate 20, a first gear 21, and a second gear 22. One end of the multiple connecting plates 20 is connected to the outer surface of the rotating column 13, and the other end of the multiple connecting plates 20 is rotatably connected to the side of the storage basket 9. The connecting plates 20 and the semi-circular groove 19 are on the same straight line. The first gear 21 is disposed on the periphery of the fixed rod 14. The second gear 22 is disposed on the other side of the storage basket 9, and the second gear 22 meshes with the first gear 21. Since the first gear 21 is fixed, when the storage basket 9 rotates around the rotating column 13, the second gear 22 drives the storage basket 9 to rotate under the meshing action of the first gear 21, so that the opening of the storage basket 9 always faces upward. When the target storage basket 9 rotates to below the door 2, the rotating disk 7 stops rotating. The round head locking block 16 engages and positions with the corresponding semi-circular groove 19, the door 2 is opened for sample loading and unloading operations, and the door 2 is closed after the operation is completed.

[0050] Combination Figure 5 As shown in the embodiment of this application, the temperature control component 12 includes an air pump 23, an air inlet pipe 24, a condenser, an evaporator, and an exhaust pipe 27. One end of the air inlet pipe 24 is connected to the air pump 23, and the other end of the air inlet pipe 24 passes through the housing 1 and communicates with the receiving cavity 4. A condensing chamber 25 is provided on the outer wall of the housing 1 for the air inlet pipe 24 to pass through, and a condenser is provided in the condensing chamber 25. An evaporating chamber 26 is provided on the outer wall of the housing 1 and on one side of the condensing chamber 25 for the air inlet pipe 24 to pass through, and an evaporator is provided in the evaporating chamber 26. The exhaust pipe 27 is connected to the right side of the housing 1 and communicates with the receiving cavity 4, and a one-way valve is provided in the exhaust pipe 27.

[0051] Combination Figure 1 and Figure 2As shown in the embodiment of this application, a door 28 is provided inside the front panel 3 and on the other side of the rotating disk 7. The door 28 facilitates opening the interior of the storage cavity 4. A temperature detector 29 is provided on the inner wall of the housing 1, and the temperature detector 29 is electrically connected to the controller 11. The temperature detector 29 monitors the temperature inside the storage cavity 4 in real time and transmits the signal to the controller 11. When the temperature is higher than the preset range, the controller 11 controls the condenser and evaporator to work. The air pump 23 draws in external gas through the air inlet pipe 24. The gas is cooled by the condenser and evaporator in sequence and then sent into the storage cavity 4. The hot gas in the storage cavity 4 is discharged through the exhaust pipe 27. A one-way valve prevents the external gas from flowing back in. When the temperature is lower or higher than the preset range, the controller 11 controls the condenser and evaporator to work to regulate the gas temperature and ensure that the temperature inside the storage cavity 4 is stable.

[0052] Combination Figure 2 As shown in the embodiment of this application, a sealing plate 30 is provided on the inner side wall of the top of the box 1 and on the left and right sides of the door 2. The lower end of the sealing plate 30 is in contact with the storage basket 9.

[0053] In the embodiments of this application, the door 2 and the box 1 are connected by a hinge, and a torsion spring is provided inside the hinge. A first magnet 31 is provided at the end of the door 2, and a second magnet 32 ​​is provided on the upper surface of the storage basket 9 in a horizontal position. When the container containing red blood cells is placed into each storage basket 9 and the door 2 is closed, the door 2 will automatically close under the action of the torsion spring. The first magnet 31 and the second magnet 32 ​​attract each other, enhancing the sealing performance. The lower end of the sealing plate 30 contacts the storage basket 9, further strengthening the seal.

[0054] In use, the controller 11 presets a suitable temperature range for red blood cell preservation (e.g., 1-6℃). The door 2 is opened, and the containers containing red blood cells are placed into the storage baskets 9. The door 2 is then closed automatically by a torsion spring. The first magnet 31 and the second magnet 32 ​​attract each other, enhancing the seal. The lower end of the sealing plate 30 contacts the storage baskets 9, further strengthening the seal. The temperature detector 29 monitors the temperature inside the storage chamber 4 in real time and transmits the signal to the controller 11. When the temperature exceeds the preset range, the controller 11 controls the condenser and evaporator to operate. The air pump 23 draws in external gas through the air inlet pipe 24. The gas is cooled by the condenser and evaporator before being sent into the storage chamber 4. The hot gas inside the storage chamber 4 is discharged through the exhaust pipe 27. A one-way valve prevents backflow of external gas. When the temperature is below or above the preset range, the controller 11 controls the condenser and evaporator to regulate the gas temperature, ensuring a stable temperature inside the storage chamber 4. When a sample needs to be placed or removed from a specific storage basket 9, the rotating disk 7 is rotated, causing the first connecting rod 15 and the rotating column 13 to rotate. The rotating column 13, through the connecting plate 20, causes the storage basket 9 to rotate as well. During rotation, the round-headed locking block 16, under the action of the telescopic spring 18, alternately engages and disengages with the semi-circular groove 19 on the first connecting rod 15, achieving positioning and unlocking. Simultaneously, since the first gear 21 remains stationary, as the storage basket 9 rotates around the rotating column 13, the second gear 22, under the meshing action of the first gear 21, drives the storage basket 9 to rotate itself, ensuring that the opening of the storage basket 9 always faces upwards. When the target storage basket 9 rotates to below the door 2, the rotating disk 7 is stopped, the round-headed locking block 16 engages and positions with the corresponding semi-circular groove 19, the door 2 is opened for sample placement or removal, and the door 2 is closed after the operation is complete.

[0055] In the description of this specification, specific features, structures, materials, or characteristics may be combined in any suitable manner in one or more embodiments or examples.

[0056] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A nanoengineered red blood cell viability preservation device, characterized in that, include: The box has a door on its upper surface and a front panel on its front side. A storage cavity is formed between the box and the front panel, and a rotating hole is provided in the front panel. A rotating assembly is rotatably installed inside the storage cavity. The inner side wall of the box has a fixing groove for one end of the rotating assembly to rotate. The other end of the rotating assembly passes through the rotating hole and is connected to a rotating disk. A locking assembly is provided between the rotating assembly and the rotating hole. A storage basket, wherein multiple storage baskets are arranged in a ring around the rotating component as the center, and rotate synchronously with the rotating component; a connecting member is provided between the storage baskets and the rotating component. The controller is connected to the front side of the front panel; A temperature control component is connected to the rear side of the housing, the temperature control component is connected to the storage cavity, and the temperature control component is electrically connected to the controller.

2. The nanoengineered erythrocyte viability preservation device according to claim 1, characterized in that, The rotating component includes: A rotating column is installed laterally inside the storage cavity; A fixed rod, one end of which is connected to one end of the rotating column, and the other end of which is rotatably installed in the fixed groove; The first connecting rod has one end connected to the other end of the rotating column, and the other end of the first connecting rod passes through the rotating hole and is connected to the rotating disk.

3. The nanoengineered erythrocyte viability preservation device according to claim 2, characterized in that, The card locking assembly includes: A round-headed locking block has a storage groove on the side wall of the rotating hole, and the round-headed locking block is slidably installed in the storage groove; A telescopic spring is located inside the storage slot. One end of the telescopic spring is connected to the inner wall of the storage slot, and the other end of the telescopic spring is connected to the round head block. A plurality of semicircular grooves are formed on the outer surface of the first connecting rod, and the round end of the round head block engages with the semicircular groove.

4. The nanoengineered erythrocyte viability preservation device according to claim 3, characterized in that, The connector includes: A connecting plate, one end of which is connected to the outer surface of the rotating column, and the other end of which is rotatably connected to the side of the storage basket. The connecting plate and the semi-circular groove are on the same straight line. The first gear is disposed on the periphery of the fixed rod; The second gear is located on the other side of the storage basket, and the second gear meshes with the first gear.

5. The nanoengineered erythrocyte viability preservation device according to claim 1, characterized in that, The temperature control component includes: air pump; An air intake pipe is connected at one end to the air pump, and at the other end of the air intake pipe passes through the housing and is connected to the storage cavity. A condenser is provided in the outer wall of the housing, through which the air inlet pipe passes, and the condenser is installed in the condenser chamber; An evaporator is provided in the outer wall of the housing and on one side of the condensation chamber, through which the air inlet pipe passes. The evaporator is installed in the evaporation chamber. An exhaust pipe is connected to the right side of the housing and communicates with the storage cavity. A one-way valve is installed inside the exhaust pipe.

6. The nanoengineered erythrocyte viability preservation device according to claim 1, characterized in that, A door is provided inside the front panel and on the other side of the rotating disk. A temperature detector is provided on the inner wall of the box, and the temperature detector is electrically connected to the controller.

7. The nanoengineered erythrocyte viability preservation device according to claim 1, characterized in that, A sealing plate is provided on the inner side wall of the top of the box and on the left and right sides of the door. The lower end of the sealing plate is in contact with the storage basket.

8. The nanoengineered erythrocyte viability preservation device according to claim 1, characterized in that, The door and the box are connected by a hinge, and a torsion spring is provided inside the hinge. A first magnet is provided at the end of the door, and a second magnet is provided on the upper surface of the storage basket at a horizontal position.

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