A medicinal and edible Chinese medicine composition with the effects of regulating immunity, relieving fatigue and benefiting throat and its preparation method

Abstract

The application discloses a kind of homoeopathy medicine composition with the efficacy of regulating immunity, relieving fatigue and benefiting throat and its preparation method, belong to homoeopathy medicine composition technical field, the preparation raw material of the traditional Chinese medicine composition includes phyllanthus emblica 100 parts, astragalus 30~70 parts, medlar 30~70 parts, platycodon 1~20 parts, mint 1~20 parts, preparation method includes phyllanthus emblica, astragalus, platycodon, mint is crushed into coarse powder, adding the step of 50wt% or above concentration ethanol aqueous solution, ultrasonic and heating treatment, and the step of adding water in medlar and ultrasonic treatment, the traditional Chinese medicine composition with phyllanthus emblica as main functional raw material with the efficacy of benefiting throat and relieving fatigue, compound can synergistically regulate immunity, astragalus, medlar, platycodon, mint, and by optimizing extraction process, can realize traditional Chinese medicine composition good sensory quality and the efficacy of regulating immunity, relieving fatigue and benefiting throat.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medicinal and edible Chinese medicine composition, and particularly relates to a medicinal and edible Chinese medicine composition with the effects of regulating immunity, relieving fatigue and benefiting throat and a preparation method thereof. BACKGROUND

[0002] The existing medicinal and edible Chinese medicine composition or beverage has the problems of poor taste and single function, and it is difficult to meet the dual requirements of experience and function of consumers.

[0003] As a state-identified medicinal and edible material, emblic leafflower fruit is rich in active ingredients such as polyphenols and vitamin C, and has various health functions such as clearing heat and benefiting throat, antioxidant and liver protection. Its application value is significant. However, its own strong astringent taste and cool nature limit its deep development in medicinal and edible Chinese medicine composition or beverage.

[0004] Therefore, how to retain the core functional ingredients of emblic leafflower fruit, effectively improve its sensory quality, and develop a new medicinal and edible Chinese medicine composition or beverage product with pleasant taste, functional synergy and suitable for daily consumption of sub-health population by compounding other functional ingredients is a technical problem to be solved in the field. SUMMARY

[0005] In view of the above problems in the prior art, a medicinal and edible Chinese medicine composition with the effects of regulating immunity, relieving fatigue and benefiting throat and a preparation method thereof are provided. The medicinal and edible Chinese medicine composition takes emblic leafflower fruit with the effects of benefiting throat and relieving fatigue as the main functional raw material, and is compounded with astragalus, medlar, platycodon grandiflorum and dried tangerine or orange peel which can synergistically regulate immunity, benefit throat and adjust taste. By optimizing the extraction process, the medicinal and edible Chinese medicine composition can achieve good sensory quality and the effects of regulating immunity, relieving fatigue and benefiting throat.

[0006] The first object of the present application is to provide a medicinal and edible Chinese medicine composition with the effects of regulating immunity, relieving fatigue and benefiting throat. The preparation raw materials include, by weight, 100 parts of emblic leafflower fruit, 30-70 parts of astragalus, 30-70 parts of medlar, 1-20 parts of platycodon grandiflorum and 1-20 parts of mint.

[0007] The preparation method comprises the following steps:

[0008] The emblic leafflower fruit, astragalus, platycodon grandiflorum and mint are weighed by weight, crushed into coarse powder, added with an ethanol aqueous solution with a concentration of 50wt% or more, ultrasonically treated and heated, filtered, and a mixture A is obtained.

[0009] The medlar is weighed by weight, added with water, ultrasonically treated, filtered, and a mixture B is obtained.

[0010] Mixing the mixture A with the mixture B to obtain the medicinal and edible Chinese medicine composition with the effects of regulating immunity, relieving fatigue and benefiting throat.

[0011] For the medicinal and edible Chinese medicine composition, the emblic leafflower as the monarch drug has high antioxidant activity, can remove excess free radicals after fatigue, and quickly restore energy. Meanwhile, it can directly act on the pharyngeal mucosa to relieve swelling and discomfort. The astragalus and medlar as the ministerial drug, the former can deeply supplement energy, enhance immunity and anti-fatigue, and the latter can nourish the liver and kidney yin. The former and the latter can form a pattern of "qi and yin dual supplementation" to synergistically regulate immunity and benefit throat. The platycodon and mint as the auxiliary drug, the former can directly reach the throat to strengthen the effect of benefiting throat, and the latter can bring a cooling sensation to instantly relieve throat itching and burning, and improve the flavor level.

[0012] In some embodiments of the present application, the preparation raw materials further include 1-20 parts of dried tangerine or orange peel. The dried tangerine or orange peel can regulate qi and invigorate the spleen, promote the absorption of tonifying ingredients, resolve greasy feeling, add fruity aroma, and neutralize the initial astringency of emblic leafflower.

[0013] In some embodiments of the present application, the preparation raw materials further include 1-20 parts of licorice. The licorice can soften the astringency of emblic leafflower with natural sweetness, return sweetness, and ensure smoothness in the mouth.

[0014] The second object of the present application is to provide a preparation method of the medicinal and edible Chinese medicine composition with the effects of regulating immunity, relieving fatigue and benefiting throat, which comprises the following steps:

[0015] S1. Weigh the emblic leafflower, astragalus, platycodon and mint, and optionally dried tangerine or orange peel and optionally licorice by weight parts, crush them into coarse powder, add an ethanol aqueous solution with a concentration of 50wt% or more, ultrasonically treat and heat, filter to obtain a mixture A;

[0016] S2. Weigh the medlar by weight parts, add water, ultrasonically treat, filter to obtain a mixture B;

[0017] S3. Mix the mixture A with the mixture B to obtain the medicinal and edible Chinese medicine composition.

[0018] In some embodiments of the present application, after the filtering step in S1 and / or S2, a step of concentration is further included.

[0019] In some embodiments of the present application, in S1, the concentration of the ethanol aqueous solution is 50wt%-90wt%.

[0020] In some embodiments of the present application, in S1, the ratio of the amount of the aqueous ethanol solution to the amount of the crude powder is 3-20 L:1 Kg.

[0021] In some embodiments of the present application, in S1, the frequency of the ultrasound is 15-40 kHz.

[0022] In some embodiments of the present application, in S1, the temperature of the heating is 50-85℃.

[0023] In some embodiments of the present application, in S1, the processing time is 30 minutes-6 hours.

[0024] In some embodiments of the present application, in S2, the ratio of the amount of the water to the amount of the wolfberry fruit is 3-15 L:1 Kg.

[0025] In some embodiments of the present application, in S2, the frequency of the ultrasound is 15-40 kHz.

[0026] In some embodiments of the present application, in S2, the ultrasound treatment further comprises a heating step.

[0027] In some embodiments of the present application, in S2, the ultrasound treatment time is 20 minutes-5 hours.

[0028] In some embodiments of the present application, in S2, the heating temperature during the ultrasound treatment is 35-100℃.

[0029] A third object of the present application is to provide a preparation having the effects of regulating immunity, relieving fatigue, and benefiting the throat, which comprises the above-mentioned homoeopathic Chinese medicinal composition having the effects of regulating immunity, relieving fatigue, and benefiting the throat, and a pharmaceutically acceptable excipient or a food acceptable excipient.

[0030] In some embodiments of the present application, the pharmaceutically acceptable excipient comprises at least one of a diluent, a wetting agent, a binder, a disintegrant, a preservative, a lubricant, a surface active agent, a penetration enhancer.

[0031] In some embodiments of the present application, the food acceptable excipient comprises at least one of an antioxidant, a flavor enhancer, a preservative, a sweetener, a thickener, an emulsifier, a stabilizer, a food flavor.

[0032] In some embodiments of the present application, the dosage form of the preparation comprises a granule or a liquid dosage form.

[0033] In some embodiments of the present application, the preparation is a liquid beverage or a solid beverage.

[0034] Compared with the prior art, the present application has the following beneficial effects:

[0035] 1) The preparation raw materials of the medicinal and edible traditional Chinese medicine composition of the present application are reasonably matched, and the monarch drug, the ministerial drug and the auxiliary drug jointly act to obtain good sensory quality, and also obtain the effects of regulating immunity, relieving fatigue and benefiting the throat;

[0036] 2) The medicinal and edible traditional Chinese medicine composition of the present application uses different processes to treat different preparation raw materials, which can effectively adjust and enrich the types and contents of active ingredients, so as to form a pattern of "dual tonifying of qi and yin", and synergistically regulate immunity and benefit the throat;

[0037] 3) The medicinal and edible traditional Chinese medicine composition of the present application can be prepared into solid and liquid, and can be prepared into a beverage with good taste and health care function. DETAILED DESCRIPTION

[0038] In order for those skilled in the art to better understand the technical solutions in the present application, the technical solutions of the present application will be described clearly and completely in combination with the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor should be within the scope of protection of the present application.

[0039] All raw materials of the present application are from the market unless otherwise specified.

[0040] Preparation Example 1

[0041] The present preparation example provides a medicinal and edible composition with the effects of regulating immunity, relieving fatigue and benefiting the throat, and the preparation raw materials thereof are, by weight, Emblica 100 parts, Astragalus 30 parts, Fructus Lycii 70 parts, Platycodon 10 parts and Mentha 10 parts; and the preparation method thereof is as follows:

[0042] Step (1), Emblica, Astragalus, Platycodon and Mentha are weighed by weight parts, crushed into coarse powder, and 50wt% ethanol aqueous solution is added in an amount of 13L / 1Kg of coarse powder, 30kHz ultrasonic, 70℃ heating treatment for 2 hours, filtration, and concentration to 1 / 13 of the original volume to obtain mixture A;

[0043] Step (2), Fructus Lycii is weighed by weight parts, and water is added in an amount of 8L / 1Kg of Fructus Lycii, 30kHz ultrasonic treatment at room temperature for 2 hours, filtration, and concentration to 1 / 8 of the original volume to obtain mixture B;

[0044] Step (3), mixture A and mixture B are mixed to obtain the medicinal and edible composition.

[0045] Preparation Example 2

[0046] The preparation example provides a kind of medicine food homologous composition with the efficacy of regulating immunity, relieving fatigue and benefiting throat, and preparation raw materials are as follows by weight: 100 parts of phyllanthus emblica, 50 parts of astragalus, 50 parts of medlar, 10 parts of platycodon grandiflorum, and 10 parts of mint;The preparation method is as follows:

[0047] Step (1), phyllanthus emblica, astragalus, platycodon grandiflorum and mint are weighed by weight parts, and are crushed into coarse powder, and 10L / 1Kg of coarse powder is added to 70wt% ethanol aqueous solution, 30kHz ultrasonic, 60℃ heating treatment for 2 hours, filtration, concentration to 1 / 10 of original volume, to obtain mixture A;

[0048] Step (2), medlar is weighed by weight parts, and 10L / 1Kg of medlar is added to water, 30kHz ultrasonic, 60℃ heating treatment for 2 hours, filtration, concentration to 1 / 10 of original volume, to obtain mixture B;

[0049] Step (3), mixture A and mixture B are mixed to obtain the medicine food homologous composition.

[0050] Preparation example 3

[0051] The preparation example provides a kind of medicine food homologous composition with the efficacy of regulating immunity, relieving fatigue and benefiting throat, and preparation raw materials are as follows by weight: 100 parts of phyllanthus emblica, 70 parts of astragalus, 30 parts of medlar, 10 parts of platycodon grandiflorum, and 10 parts of mint;The preparation method is as follows:

[0052] Step (1), phyllanthus emblica, astragalus, platycodon grandiflorum and mint are weighed by weight parts, and are crushed into coarse powder, and 8L / 1Kg of coarse powder is added to 90wt% ethanol aqueous solution, 30kHz ultrasonic, 50℃ heating treatment for 4 hours, filtration, concentration to 1 / 8 of original volume, to obtain mixture A;

[0053] Step (2), medlar is weighed by weight parts, and 6L / 1Kg of medlar is added to water, 30kHz ultrasonic, 50℃ heating treatment for 4 hours, filtration, concentration to 1 / 6 of original volume, to obtain mixture B;

[0054] Step (3), mixture A and mixture B are mixed to obtain the medicine food homologous composition.

[0055] Preparation example 4

[0056] The preparation example provides a kind of medicine food homologous composition with the efficacy of regulating immunity, relieving fatigue and benefiting throat, and the difference between preparation example 2 is only that preparation raw materials also include 16 parts of dried tangerine or orange peel, and phyllanthus emblica, astragalus, platycodon grandiflorum, mint and dried tangerine or orange peel are crushed into coarse powder by weight parts in step (1). The rest is consistent with preparation example 2.

[0057] Preparation example 5

[0058] The present preparation example provides a kind of medicine food composition with the efficacy of regulating immunity, relieving fatigue and benefiting throat, which is only different from preparation example 2 in that the preparation raw material further includes 16 parts of liquorice, and the remaining parts of phyllanthus emblica, astragalus, platycodon, mint and liquorice are crushed into coarse powder in step (1). The rest is consistent with preparation example 2.

[0059] Preparation example 6

[0060] The present preparation example provides a kind of medicine food composition with the efficacy of regulating immunity, relieving fatigue and benefiting throat, which is only different from preparation example 2 in that the preparation raw material further includes 8 parts of dried tangerine or orange peel and 8 parts of liquorice, and the remaining parts of phyllanthus emblica, astragalus, platycodon, mint, dried tangerine or orange peel and liquorice are crushed into coarse powder in step (1). The rest is consistent with preparation example 2.

[0061] Comparative preparation example 1

[0062] The present comparative preparation example provides a kind of medicine food composition, and the preparation raw material is 100 parts of phyllanthus emblica, 50 parts of astragalus, 50 parts of medlar, 10 parts of platycodon and 10 parts of mint by weight; and the preparation method is as follows:

[0063] The remaining parts of phyllanthus emblica, astragalus, medlar, platycodon and mint are crushed into coarse powder, and 10L / 1Kg of coarse powder is added to an ethanol aqueous solution with a concentration of 70wt%, and then ultrasonic treatment is carried out at 30kHz and heated at 60℃ for 2 hours. After filtration, the volume is concentrated to 1 / 10 of the original volume to obtain the medicine food composition.

[0064] Comparative preparation example 2

[0065] The present comparative preparation example provides a kind of medicine food composition, which is only different from preparation example 2 in that the preparation raw material is 100 parts of phyllanthus emblica, 100 parts of astragalus, 10 parts of platycodon and 10 parts of mint, and the corresponding preparation method does not include steps (2) and (3). The rest is consistent with preparation example 2.

[0066] Comparative preparation example 3

[0067] The present comparative preparation example provides a kind of medicine food composition, which is only different from preparation example 2 in that the preparation raw material is 100 parts of phyllanthus emblica, 100 parts of medlar, 10 parts of platycodon and 10 parts of mint, and the remaining parts of phyllanthus emblica, platycodon and mint are crushed into coarse powder in step (1). The rest is consistent with preparation example 2.

[0068] Example 1

[0069] The present embodiment provides a kind of medicinal and edible traditional Chinese medicine composition: take the medicinal and edible composition of preparation example 1, according to 1g preparation raw material: 2mL water is added to 50 ℃ warm water, stirring uniformly, cooling, respectively, medicinal and edible traditional Chinese medicine composition A is obtained.

[0070] Examples 2~3 and Comparative Examples 1~3

[0071] The present embodiment and comparative example provide a kind of medicinal and edible traditional Chinese medicine composition, which is only different from the embodiment 1 in that: respectively take the medicinal and edible composition of preparation example 2~3 and comparative preparation example 1~3, and respectively obtain medicinal and edible traditional Chinese medicine composition B, C, D, E, F.

[0072] Performance test

[0073] 1、Sensory test

[0074] Take the medicinal and edible composition of preparation example 1~6 and comparative preparation example 1~3 5g, add 45mL water to prepare medicinal and edible beverage A, B, C, D, E, F, G, H, I; randomly select 20 people with dry throat in the past week as the evaluation team, half of men and women, 21~40 years old, 41~60 years old, half of each; each evaluator drinks the above medicinal and edible beverage A~I, respectively from the initial astringency, throat moist feeling, overall taste, overall flavor, and evaluates it, wherein:

[0075] For initial astringency, 1~5 points represent very strong, strong, general, slight, none;

[0076] For throat moist feeling, 1~5 points represent none, slight, general, strong, very strong;

[0077] For overall taste and overall flavor, 1~5 points represent very poor, poor, general, good, very good;

[0078] The number of people corresponding to different sensory properties is counted, and the average score is calculated, as shown in table 1, the higher the score, the better the sensory quality.

[0079] Table 1

[0080]

[0081] 2、Efficacy study

[0082] 2.1、Chronic pharyngitis model of Kunming mice and lymphocyte proliferation test

[0083] Screen healthy male Kunming mice with body weight of 28-30 g, and adaptively feed for 7 days. Then, the mice are modeled according to the following method: 10% ammonia water is placed in a sprayer, and 2 sprays of the ammonia water are sprayed to the pharynx of each mouse, 3 times a day, with an interval of 8 h each time, for 21 days. The general conditions of the mice are observed, and when rough and dull fur, increased oral secretion and water intake, side head scratching, lip scratching, and other actions are observed, and when the pharynx of the mouse is observed to have hyperemia and swelling, and a large amount of secretion adheres to the pharynx, it is determined that the modeling is successful.

[0084] Then, the mice successfully modeled are randomly divided into 8 groups, with 6 mice in each group, and each group of mice is treated as follows:

[0085] The negative control group is orally administered with 12 mL / kg of normal saline.

[0086] The positive control group is orally administered with 12 mL / kg of Liyin oral liquid.

[0087] The example 1-3 and the comparative example 1-3 groups are respectively orally administered with 12 mL / kg of the above-mentioned medicinal and edible Chinese medicinal composition A-F (converted to 6 g of the preparation raw material per kg of mice).

[0088] Another group of adaptively fed Kunming mice that are not modeled is taken as a blank group, and the mice are orally administered with 12 mL / kg of normal saline.

[0089] The above treatment is continuously performed once a day for 21 days.

[0090] 24 h after the above treatment is completed, the mice are observed and scored according to the following method:

[0091] The mouse pharynx is scored as 0 if the pharynx is moist and shiny, has no hyperemia, swelling, and other pathological symptoms, and is light red, and no secretion adheres to the pharynx.

[0092] The mouse pharynx is scored as 1 if the pharynx is shiny, has a small amount of acute hyperemia, and a small amount of secretion adheres to the pharynx.

[0093] The mouse pharynx is scored as 2 if the pharynx is dark in color, has acute and mild swelling, and adheres to secretion.

[0094] The mouse pharynx is scored as 3 if the pharynx is dark red and dark in color, has obvious acute hyperemia and swelling, and adheres to a large amount of secretion.

[0095] The average score of the mice in each group is calculated, and the results are shown in Table 2. The lower the score, the better the effect of Liyin Runhou.

[0096] After the above observation, the mice in the blank group and the groups of examples 1-3 and comparative examples 1-3 were killed by cervical dislocation, and the ConA-induced mouse spleen lymphocyte transformation experiment in the test method for the function of enhancing immunity in the health food function evaluation procedure and test method was used for determination: MTT method, the lymphocyte proliferation capacity was determined, and the results were shown in Table 2. In the table, the optical density value OD at 570 nm was determined by a semi-automatic biochemical analyzer; the lymphocyte proliferation capacity = OD of the ConA-added well-OD of the ConA-unadded well, and the greater the value, the stronger the immunity.

[0097] 2.2, Weight-loaded swimming test of Kunming mice

[0098] Healthy male Kunming mice with a weight of 28-30 g were screened, adaptively fed for 7 days, and finally randomly divided into 7 groups, 6 mice in each group, and each group was treated as follows:

[0099] The blank group: 12 mL / Kg of normal saline was orally administered;

[0100] The groups of examples 1-3 and comparative examples 1-3: 12 mL / Kg of the above medicinal and edible traditional Chinese medicine composition A-F (6 g of the preparation raw material / Kg of mice after conversion) was orally administered.

[0101] The above treatment was continuously performed once a day for 3 days, and during the oral administration, the mice were placed in a 700 hPa low-pressure environment.

[0102] 30 min after the above treatment, the tail of each mouse was loaded with 5% body weight of lead, and the mouse was placed in a swimming box (water depth 30 cm, water temperature 25℃) to swim, and the time from the start of swimming to exhaustion (the mouse's head was completely submerged in water for 10 seconds and could not float out of the water) was recorded, that is, the weight-loaded swimming time, and the results were shown in Table 2.

[0103] Table 2

[0104]

[0105] As shown in Table 1, the medicinal and edible traditional Chinese medicine composition prepared by the preparation examples 1-6 has relatively weak initial astringency, strong throat moistening, good overall taste and overall flavor, that is, good sensory quality; as shown in Table 2, the medicinal and edible traditional Chinese medicine composition prepared by the examples 1-3 has the effects of soothing the throat, enhancing immunity and relieving fatigue. Therefore, the medicinal and edible traditional Chinese medicine composition of the present application can be used as a daily beverage with good taste and health care function.

[0106] In contrast, the comparative example 1 in which all raw materials are treated by ultrasonic heating with an ethanol aqueous solution has a poorer effect of enhancing immunity and relieving fatigue than the examples 1-3 of the present application, the comparative examples 2-3 in which the astragalus and the Chinese wolfberry are not used in combination with the "qi-yin dual supplementation" pattern have a poorer effect of soothing the throat and enhancing immunity than the examples 1-3 of the present application, and all of them cannot have good multiple effects in the health care function.

[0107] It should be finally pointed out that the above examples are only used to illustrate the technical solutions of the present application but not to limit the same, and although the present application has been described in detail with reference to the above examples, those skilled in the art should understand that the specific embodiments of the present application can be modified or replaced by the equivalents after reading the present application, but these modifications or changes are still within the scope of the present application.

Claims

1. A medicinal and edible herbal composition with the effects of regulating immunity, relieving fatigue, and soothing the throat, characterized in that, The raw materials for preparation, by weight, include: 100 parts of Phyllanthus emblica, 30-70 parts of Astragalus membranaceus, 30-70 parts of Lycium barbarum, 1-20 parts of Platycodon grandiflorus, and 1-20 parts of Mentha haplocalyx. Its preparation method includes the following steps: Weigh out the following ingredients by weight: Phyllanthus emblica, Astragalus membranaceus, Platycodon grandiflorus, and Mentha haplocalyx. Crush them into coarse powder, add them to an ethanol aqueous solution with a concentration of 50wt%~90wt%, sonicate and heat them, filter them, and obtain mixture A. Weigh out the wolfberries by weight, add water, sonicate, filter, and obtain mixture B; Mixing mixture A with mixture B yields the medicinal and edible herbal composition that has the effects of regulating immunity, relieving fatigue, and soothing the throat.

2. The medicinal and edible herbal composition according to claim 1, characterized in that, The raw materials for preparation also include 1 to 20 parts of dried tangerine peel.

3. The medicinal and edible herbal composition according to claim 1, characterized in that, The raw materials for preparation also include 1 to 20 parts of licorice.

4. The method for preparing the medicinal and edible herbal composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: S1. Weigh out the following ingredients by weight: Phyllanthus emblica, Astragalus membranaceus, Platycodon grandiflorus, Mentha haplocalyx, and optionally Citrus reticulata peel and Glycyrrhiza uralensis. Crush them into coarse powder, add them to an ethanol aqueous solution with a concentration of 50wt%~90wt%, sonicate and heat them, filter them, and obtain mixture A. S2. Weigh the wolfberries according to the weight, add water, sonicate, filter, and obtain mixture B; S3. Mix mixture A and mixture B to obtain the medicinal and edible herbal composition.

5. The preparation method according to claim 4, characterized in that, In S1 and / or S2, a concentration step is included after the filtration step.

6. The preparation method according to claim 4, characterized in that, In S1, the ratio of the ethanol aqueous solution to the coarse powder is 3~20L:1Kg; And / or, the frequency of the ultrasound is 15~40kHz; And / or, the heating temperature is 50~85°C; And / or, the processing time is 30 minutes to 6 hours.

7. The preparation method according to claim 4, characterized in that, In S2, the ratio of water to wolfberry is 3~15L:1Kg; And / or, the frequency of the ultrasound is 15~40kHz; And / or, the ultrasonic treatment process further includes a heating step; And / or, the duration of the ultrasonic treatment is 20 minutes to 5 hours.

8. The preparation method according to claim 7, characterized in that, The heating temperature during the ultrasonic treatment process is 35~100℃.

9. A preparation having the effects of regulating immunity, relieving fatigue, and soothing the throat, characterized in that, It includes the medicinal and edible herbal composition as described in any one of claims 1 to 3, and pharmaceutically acceptable excipients or food-acceptable excipients.

10. The formulation according to claim 9, characterized in that, The dosage form of the preparation includes granules or liquids.

11. The formulation according to claim 9, characterized in that, The preparation is a liquid beverage or a solid beverage.

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