Anti-hair loss shampoo composition and preparation method thereof

Abstract

The invention relates to the field of daily chemical products, and discloses an anti-hair loss shampoo composition and a preparation method thereof.The anti-hair loss shampoo composition is prepared from, by weight, 5-15 parts of cacumen biotae extract; 2-8 parts by weight of caffeine; 1-5 parts by weight of azelaic acid; 3 to 10 parts by weight of succinyl glycan; 1.5 to 3.5 parts by weight of D-panthenol; 0.1 to 0.3 part by weight of sodium hyaluronate; 5 to 10 parts by weight of sodium lauroyl sarcosinate; 5-10 parts by weight of sodium cocoyl glutamate; 0.1 to 0.3 part by weight of essence; 30 to 80 parts by weight of purified water; 0.2 to 0.5 part by weight of xanthan gum; 5-10 parts by weight of vegetable oil; 1.5 to 3 parts by weight of polyglycerol-6 octoate; 0.5 to 2 parts by weight of tocopherol; the succinyl glycan is subjected to hydrophobic modification treatment. By optimizing a formula and a preparation process, the anti-hair-loss shampoo composition has good stability and a good anti-hair-loss effect.

Description

Technical Field

[0001] This application relates to the field of daily chemical products, and mainly to an anti-hair loss shampoo composition and its preparation method. Background Technology

[0002] Shampoo, as a common personal care product, primarily functions to cleanse the hair and scalp. As consumers' demands for shampoo efficacy increase, moisturizing, conditioning, and repairing functions are also gaining importance in addition to cleansing. Currently, there are many types of shampoos on the market, but shampoos targeting hair loss often suffer from problems such as insignificant effects and limited mechanisms of action. Hair loss typically involves multiple factors, including hair follicle atrophy, scalp inflammation, and poor blood circulation. Therefore, shampoos with a single active ingredient may not meet the needs of all users. While some compound anti-hair loss shampoos exist, the characteristics of each active ingredient are different, and different active ingredients may interact, affecting the stability or effectiveness of the shampoo and failing to achieve a synergistic effect. Therefore, how to optimize the ratio of multiple active ingredients to construct a multi-target, multi-mechanism hair growth system, improving the stability and transdermal absorption efficiency of active ingredients, is a pressing technical problem to be solved in the shampoo industry.

[0003] Therefore, existing technologies still need to be improved and developed. Summary of the Invention

[0004] In view of the shortcomings of the prior art, the purpose of this application is to provide an anti-hair loss shampoo composition and its preparation method, aiming to solve the problem that the stability and effectiveness of existing anti-hair loss shampoos need to be improved.

[0005] The technical solution of this application is as follows: An anti-hair loss shampoo composition, comprising, by weight, the following ingredients: Platycladus orientalis leaf extract: 5-15 parts by weight; Caffeine: 2-8 parts by weight; Azelaic acid: 1-5 parts by weight; Succinyl polysaccharide: 3-10 parts by weight; D-Panthenol: 1.5-3.5 parts by weight; Sodium hyaluronate: 0.1-0.3 parts by weight; Sodium lauroyl sarcosinate: 5-10 parts by weight; Sodium cocoyl glutamate: 5-10 parts by weight; Fragrance: 0.1-0.3 parts by weight; Purified water: 30-80 parts by weight; The succinyl polysaccharide has undergone hydrophobic modification treatment; The hydrophobic modification process of the succinyl polysaccharide includes the following steps: Step 1: Dissolve the succinyl polysaccharide in deionized water to prepare a succinyl polysaccharide solution; Step 2: Under stirring conditions, add octenyl succinic anhydride to the succinyl polysaccharide solution, adjust the pH value to 8.0-8.5, and react at 35-45℃ for 2.5-3.5 hours; Step 3: After the reaction is complete, adjust the pH of the solution to neutral and dialyze. Step 4: Under stirring conditions, add lecithin to the dialyzed solution and disperse it evenly; Step 5: Spray dry the solution from step 4 to obtain solid hydrophobic modified succinopolysaccharide.

[0006] The aforementioned anti-hair loss shampoo composition, wherein the anti-hair loss shampoo composition, by weight parts, further comprises the following ingredients: Xanthan gum: 0.2-0.5 parts by weight; Vegetable oil: 5-10 parts by weight; Polyglycerol-6 octanoate: 1.5-3 parts by weight; Tocopherol: 0.5-2 parts by weight.

[0007] The aforementioned anti-hair loss shampoo composition, wherein the anti-hair loss shampoo composition, by weight parts, further comprises the following ingredients: Fragrance: 0.1-0.3 parts by weight.

[0008] The aforementioned anti-hair loss shampoo composition, wherein the anti-hair loss shampoo composition, by weight parts, further comprises the following ingredients: Citric acid or sodium hydroxide: 0.01-2 parts; The pH of the anti-hair loss shampoo composition is adjusted to between 5.5 and 6.5 using either the citric acid or the sodium hydroxide.

[0009] The anti-hair loss shampoo composition wherein the mass ratio of the octenyl succinic anhydride to the succinopolysaccharide is 0.02-0.08:1, and the mass ratio of the lecithin to the succinopolysaccharide is 0.4-0.6:100.

[0010] The anti-hair loss shampoo composition, wherein in step 1, the mass concentration of the succinopolysaccharide solution is 5%.

[0011] The hair loss prevention shampoo composition, wherein in step 3, dialysis is performed using a dialysis bag with a molecular weight cutoff of 1000 Da for 24 hours, and the deionized water is replaced every 4 hours.

[0012] The hair loss prevention shampoo composition, wherein in step 5, the spray drying conditions are an inlet air temperature of 120°C, an outlet air temperature of 70°C, and a feed rate of 5 mL / min.

[0013] A method for preparing the anti-hair loss shampoo composition as described above, comprising the following steps: Azelaic acid, succinosaccharide, vegetable oil, polyglycerol-6 octanoate and tocopherol are mixed, heated to 70-75℃ and stirred until homogeneous to obtain the oil phase; D-panthenol, caffeine and the first part of purified water of the arborvitae leaf extract were mixed to obtain a water-polyol phase; The oil phase is added to the water-polyol phase and stirred in a homogenizer at a speed of 3000-5000 rpm for 5-10 minutes to obtain a gel. The mixture is stirred at 2000-3000 rpm in the homogenizer, and a second portion of purified water is added to the gel to form a nanoemulsion. Add sodium hyaluronate to the purified water in the third part at a stirring speed of 300-400 rpm, stir well, then add sodium lauroyl sarcosinate and sodium cocoyl glutamate, stir for 20-30 minutes to obtain the shampoo base. Add xanthan gum to the purified water in the fourth part and disperse it using a high-speed disperser at a speed of 10,000-12,000 rpm for 15-20 minutes to obtain a xanthan gum solution. At a stirring speed of 300-400 rpm, the nanoemulsion is added to the shampoo base and stirred evenly, and then the xanthan gum solution is added and stirred evenly. The first part of purified water accounts for 15-20% of the total amount of purified water, the second part accounts for 50-60% of the total amount of purified water, the third part accounts for 13-32% of the total amount of purified water, and the fourth part accounts for 3-7% of the total amount of purified water.

[0014] The method for preparing the aforementioned anti-hair loss shampoo composition further includes the following steps: Add flavoring and stir well; Adjust the pH to 5.5-6.5 using citric acid or sodium hydroxide.

[0015] Beneficial Effects: The anti-hair loss shampoo composition of this application employs a multi-target active ingredient combined with a hair growth promoting system, comprehensively considering various factors affecting hair growth, and can more effectively promote hair growth to achieve the effect of preventing hair loss. At the same time, through optimized formulation and preparation process, the anti-hair loss shampoo composition of this application possesses good stability and good anti-hair loss efficacy. Attached Figure Description

[0016] Figure 1 This is a comparison chart showing the stability test results of the products in Examples 1-2 and Comparative Examples 1-2 of this application.

[0017] Figure 2 This is a comparison diagram of the foam height effect in Examples 1-2 of this application.

[0018] Figure 3 These are before-and-after photos of hair taken by volunteers who used the product of Example 1 in this application. Detailed Implementation

[0019] This application provides an anti-hair loss shampoo composition and its preparation method. To make the purpose, technical solution, and effects of this application clearer and more explicit, the following provides a more detailed description. It should be understood that the specific embodiments described herein are merely illustrative of this application and are not intended to limit this application.

[0020] This application provides an anti-hair loss shampoo composition, comprising the following raw materials in parts by weight: Platycladus orientalis leaf extract: 5-15 parts by weight; Caffeine: 2-8 parts by weight; Azelaic acid: 1-5 parts by weight; Succinyl polysaccharide: 3-10 parts by weight; D-Panthenol: 1.5-3.5 parts by weight; Sodium hyaluronate: 0.1-0.3 parts by weight; Sodium lauroyl sarcosinate: 5-10 parts by weight; Sodium cocoyl glutamate: 5-10 parts by weight; Purified water: 30-80 parts by weight.

[0021] This application employs a multi-target active ingredient combined hair growth promotion system, comprehensively considering various factors affecting hair growth. Multiple active ingredients, such as Platycladus orientalis leaf extract, caffeine, azelaic acid, and succinopolysaccharide, work synergistically to prevent hair loss and promote hair growth from multiple targets and mechanisms. Caffeine and azelaic acid have antioxidant and 5α-reductase inhibitory effects, respectively, and work synergistically with Platycladus orientalis leaf extract to target the hair loss mechanism at multiple points. Specifically, the alkaloids in Platycladus orientalis leaf extract may prevent hair loss by promoting hair follicle cell proliferation and inhibiting hair follicle cell apoptosis; azelaic acid may promote hair growth by scavenging free radicals, reducing scalp inflammation, and improving the microenvironment around hair follicles, and also has antibacterial and anti-inflammatory effects; caffeine may reduce the production of dihydrotestosterone (DHT) by inhibiting 5α-reductase activity, thereby reducing DHT damage to hair follicles, and also stimulate hair follicles, promote scalp blood circulation, and provide sufficient nutrition to hair follicles. Succinyl polysaccharide has moisturizing and repairing effects, improving the scalp environment and providing a good foundation for hair growth. D-panthenol also has moisturizing and repairing effects, improving the scalp environment. Simultaneously, as a polyol, D-panthenol is used to form a water-polyol phase, allowing the active ingredients in the shampoo composition to be prepared into nanoemulsions via the D-phase method. Sodium hyaluronate has excellent moisturizing properties, enhancing the shampoo's moisturizing effect. The shampoo composition contains some plant oils and fat-soluble components, which may lead to oily hair after shampooing, affecting the user experience. Therefore, in this formulation, sodium lauroyl sarcosinate is combined with sodium cocoyl glutamate to improve the shampoo's cleansing power. Sodium lauroyl sarcosinate, as a mild surfactant, provides the shampoo with cleansing power while minimizing skin irritation. Sodium cocoyl glutamate, an amino acid-type surfactant, has good cleansing power and gentleness, enhancing the shampoo's cleansing ability while reducing skin irritation.

[0022] In this application, the dosage of Platycladus orientalis leaf extract ranges from 5-15 parts by weight to ensure sufficient hair growth activity in the shampoo; however, excessive use may cause scalp irritation. The dosage of caffeine ranges from 2-8 parts by weight to ensure effective stimulation of hair follicles and promotion of scalp blood circulation; however, excessive use may cause scalp dryness. The dosage of azelaic acid ranges from 1-5 parts by weight to ensure effective inhibition of DHT and improvement of androgenetic alopecia; however, excessive use may cause scalp irritation. The dosage of succinopolysaccharide ranges from 3-10 parts by weight to ensure sufficient moisturizing and repairing effects and improve the scalp environment; however, excessive use may result in an excessively viscous shampoo.

[0023] Although arborvitae leaf extract, caffeine, azelaic acid, succinopolysaccharide, and other ingredients can have a synergistic effect, the stability of the combination needs to be considered because existing shampoos are not ready to use immediately. In actual use, the combination of multiple active ingredients may have poor stability, and long-term storage may result in layering and decreased efficacy.

[0024] The stability of succinosaccharides in shampoo systems is affected by factors such as pH, temperature, and ionic strength. In the acidic environment of azelaic acid, succinosaccharides may undergo hydrolysis or degradation, leading to a reduction in their moisturizing and thickening effects. Therefore, in this application, the succinosaccharides undergo hydrophobic modification treatment, specifically including the following steps: Step 1: Dissolve succinosaccharide in deionized water to prepare a 5% (w / w) succinosaccharide solution. In this step, under stirring conditions, slowly add the succinosaccharide to the deionized water to ensure complete dissolution and prevent clumping. The stirring speed can be 200 rpm.

[0025] Step 2: Under stirring conditions, add octenyl succinic anhydride (OSA) to the succinosaccharide solution at a mass ratio of OSA to succinosaccharide of 0.02-0.08:1. Adjust the pH of the solution to 8.0-8.5 and react at 40°C for 3 hours. In this step, octenyl succinic acid groups are introduced through the reaction of OSA with the hydroxyl groups on the succinosaccharide. The stirring speed in this step can be 200 rpm, and the pH of the solution can be adjusted using sodium hydroxide solution or hydrochloric acid. Maintaining the pH at 8.0-8.5 facilitates the opening of the cyclic anhydride of OSA and its reaction with the hydroxyl groups of the succinosaccharide. Setting the reaction temperature to 40°C accelerates the reaction rate while preventing the degradation of the succinosaccharide.

[0026] Step 3: After the reaction is complete, adjust the pH of the solution to neutral (pH=7.0), and perform dialysis using a dialysis bag with a molecular weight cutoff of 1000 Da for 24 hours. Replace the deionized water every 4 hours to remove unreacted OSA and byproducts.

[0027] Step 4: Under stirring conditions, add lecithin as a dispersant to the dialyzed solution. The mass ratio of lecithin to succinopolysaccharide is 0.4-0.6:100. In this step, the stirring speed can be 200 rpm to ensure that the lecithin is uniformly dispersed in the solution. Modified succinopolysaccharide particles are prone to agglomeration during spray drying, mainly due to the hydrophobicity of the octenyl succinic acid groups, resulting in high surface tension between particles. Lecithin is an amphiphilic molecule, containing both hydrophilic and hydrophobic groups in its molecular structure. In aqueous solution, the hydrophobic groups of lecithin can interact with the hydrophobic groups of the modified succinopolysaccharide particles, reducing the surface tension between particles and thus preventing agglomeration. Simultaneously, the hydrophilic groups of lecithin can interact with water molecules, enhancing the dispersibility of the particles in water. Reducing the spray pressure can decrease the probability of collisions between particles, further reducing agglomeration. Modified succinopolysaccharides with good dispersibility are more easily and uniformly dispersed in shampoo systems, improving shampoo stability.

[0028] Step 5: Spray dry the solution from Step 4 to obtain solid modified succinyl polysaccharide. In this step, the spray drying conditions are: inlet air temperature 120℃, outlet air temperature 70℃, and feed rate 5 mL / min.

[0029] In OSA, the cyclic anhydride undergoes an esterification reaction with the hydroxyl groups of succinopolysaccharide, grafting octenyl succinic acid groups onto the succinopolysaccharide molecule. Introducing the octenyl succinic acid groups enhances the acid resistance, salt resistance, and thermal stability of succinopolysaccharide. Furthermore, the hydrophobic nature of the octenyl succinic acid groups allows them to bind with sebum on the scalp, reducing sebum buildup on the hair and achieving an oil-controlling effect. Simultaneously, the hydrophobically modified succinopolysaccharide exhibits better film-forming properties, forming a protective film on the hair surface to prevent moisture loss and thus improve moisturizing effects.

[0030] Nanoemulsions can encapsulate active ingredients, preventing them from being affected by the external environment and improving their stability. They can also fuse with the lipid bilayer on the skin surface, delivering active ingredients to the deeper layers of the skin and improving transdermal absorption efficiency. While nanoemulsions have good transdermal absorption efficiency, their long-term stability remains a challenge, especially when containing multiple active ingredients, which may accelerate the degradation of the nanoemulsion. In this solution, a specific combination of nanoemulsion and active substances is used to improve the long-term stability of the shampoo composition. Therefore, the anti-hair loss shampoo composition of this application, by weight, also includes the following ingredients: Xanthan gum: 0.2-0.5 parts by weight; Vegetable oil: 5-10 parts by weight; Polyglycerol-6 octanoate: 1.5-3 parts by weight; Tocopherol: 0.5-2 parts by weight.

[0031] Using nanoemulsions as a carrier can improve the stability of active ingredients and transdermal absorption efficiency. The molecular structure of polyglycerol-6-octanoate contains multiple glycerol groups, which can form hydrogen bonds with water molecules, enhancing hydrophilicity and thus improving the stability of the nanoemulsion. Furthermore, polyglycerol-6-octanoate also possesses good antioxidant and hydrolysis resistance, extending the shelf life of the nanoemulsion. Simultaneously, xanthan gum is added as a stabilizer. Xanthan gum is a natural polysaccharide with excellent thickening and suspending properties, preventing nanoemulsions from layering, flocculating, and agglomerating. Xanthan gum molecules can form hydrogen bonds with water molecules, creating a three-dimensional network structure, thereby improving the viscosity and stability of the nanoemulsion.

[0032] Furthermore, the anti-hair loss shampoo composition of this application, by weight, also includes the following ingredients: Fragrance: 0.1-0.3 parts by weight.

[0033] Adding fragrance can improve the scent of shampoo compositions and enhance the consumer experience.

[0034] The anti-hair loss shampoo composition of this application further includes the following ingredients in parts by weight: Citric acid or sodium hydroxide: 0.01-2 parts.

[0035] The pH value of the anti-hair loss shampoo composition of this application is adjusted to between 5.5 and 6.5 using citric acid or sodium hydroxide, making it closer to the physiological pH value of the scalp and reducing irritation to the scalp.

[0036] This application also provides a method for preparing the above-mentioned anti-hair loss shampoo composition, comprising the following steps: Azelaic acid, succinosaccharide, vegetable oil, polyglycerol-6 octanoate and tocopherol are mixed, heated to 70-75℃ and stirred until homogeneous to obtain the oil phase; D-panthenol, caffeine and the first part of purified water of the arborvitae leaf extract were mixed to obtain a water-polyol phase; Stir at 3000-5000 rpm in a homogenizer, slowly add the oil phase to the water-polyol phase, and keep stirring for 5-10 minutes to form a uniform gel, ensuring that the gel is uniform and free of particles. Stir at 2000-3000 rpm in a homogenizer, and slowly add a second portion of purified water in batches to the gel to form a nanoemulsion; At a stirring speed of 300-400 rpm, add sodium hyaluronate to the purified water in the third part and stir well. Then add sodium lauroyl sarcosinate and sodium cocoyl glutamate and stir for 20-30 minutes to fully dissolve them to obtain the shampoo base. Slowly add xanthan gum to the purified water in the fourth part, and disperse it for 15-20 minutes using a high-speed disperser at a speed of 10,000-12,000 rpm to ensure that the xanthan gum is completely dispersed and free of lumps, thus obtaining a xanthan gum solution. At a stirring speed of 300-400 rpm, the nanoemulsion was added to the shampoo base and stirred evenly, and then the xanthan gum solution was added and stirred evenly. Add flavoring and stir well; Adjust the pH to 5.5-6.5 using citric acid or sodium hydroxide.

[0037] In this application, by employing D-phase emulsification technology, the particle size of the nanoemulsion can be reduced, improving its stability and transdermal absorption efficiency, while also reducing energy consumption. Pre-dispersing xanthan gum in a small amount of purified water prevents it from clumping in the shampoo, improving its dispersibility and thickening effect, thereby enhancing the shampoo's stability and user experience.

[0038] In this application, the amount of purified water used in the first part can be 15-20% of the total amount of purified water used, the amount of purified water used in the second part can be 50-60% of the total amount of purified water used, the amount of purified water used in the third part can be 13-32% of the total amount of purified water used, and the amount of purified water used in the fourth part can be 3-7% of the total amount of purified water used.

[0039] Furthermore, while both untreated succinosaccharide and Platycladus orientalis leaf extract are soluble in the aqueous phase, their simultaneous presence in the aqueous phase can easily lead to stratification, resulting in poor nanoemulsion stability. However, after hydrophobic modification, succinosaccharide can be dispersed in the oil phase, reducing its interaction with the Platycladus orientalis leaf extract and improving the stability of the nanoemulsion. Simultaneously, the reduced hydrogen ion release from azelaic acid in the oil phase weakens its protonation attack on succinosaccharide. The micelles formed by the emulsifier may also hinder direct contact between azelaic acid and succinosaccharide, further reducing the reaction probability and improving the stability of the nanoemulsion while protecting the activity of succinosaccharide. Therefore, in this application, a combination of azelaic acid and succinosaccharide in the oil phase, and caffeine and Platycladus orientalis leaf extract in the water-polyol phase is used.

[0040] The anti-hair loss shampoo composition of this application has the following advantages: 1. It adopts a multi-target active ingredient combined hair growth promotion system, comprehensively considering various factors affecting hair growth, and can more effectively promote hair growth to achieve the effect of preventing hair loss. 2. It uses nanoemulsion as a carrier, which can improve the stability of active ingredients and transdermal absorption efficiency. 3. Multiple active ingredients can work synergistically to promote hair growth from multiple targets and mechanisms. 4. The formula is safe and gentle, with minimal scalp irritation.

[0041] The present application will be further described below through specific embodiments.

[0042] The sources of the main raw materials in the following embodiments are as follows: Platycladus orientalis leaf extract: Liupanyun Biotechnology; Caffeine: NeoNova; Azelaic acid: Hubei Xinyuhong Biotechnology; D-Panthenol: Jiangsu Pules Biotechnology; Sodium hyaluronate: Bloomage Biotechnology; Sodium lauroyl sarcosinate: Guangzhou Bailijia Technology Co., Ltd. Sodium cocoyl glutamate: Hefei Nuolang Biotechnology; Citric acid and sodium hydroxide: Aladdin Biochemistry; Succinyl polysaccharide: Yunnan Magnesium Chemicals; Octenyl succinic anhydride: Wuhan Lanabai Pharmaceutical & Chemical Co., Ltd. Lecithin: Hubei Hongxin Ruiyu Fine Chemical Co., Ltd. Xanthan gum: Plum Blossom Biology; Vegetable oil: Croda Corporation, Limnanthes Alba (Meadowfoam) Seed Oil; Polyglycerol-6 octanoate: Wuhan Lingfan Technology; Tocopherol (Vitamin E): Zhejiang Xinhecheng.

[0043] Example 1 The formulation of the anti-hair loss shampoo composition in this embodiment is as follows: Platycladus orientalis leaf extract: 10 parts by weight; Caffeine: 5 parts by weight; Azelaic acid: 3 parts by weight; Succinyl polysaccharide: 6 parts by weight; D-Panthenol: 2.5 parts by weight; Sodium hyaluronate: 0.2 parts by weight; Sodium lauroyl sarcosinate: 8 parts by weight; Sodium cocoyl glutamate: 8 parts by weight; Xanthan gum: 0.2 parts by weight; Vegetable oil: 5 parts by weight; Polyglycerol-6 octanoate: 2 parts by weight; Tocopherol: 1 part by weight; Purified water: 50 parts by weight; Fragrance: 0.2 parts by weight; Citric acid: 0.2 parts by weight.

[0044] The succinyl polysaccharide undergoes hydrophobic modification, specifically including the following steps: Step 1: Under stirring at 200 rpm, slowly add succinyl polysaccharide to deionized water to prepare a succinyl polysaccharide solution with a mass concentration of 5%, ensuring complete dissolution and no clumping.

[0045] Step 2: Under stirring at 200 rpm, add octenyl succinic anhydride to the succinopolysaccharide solution. The mass ratio of OSA to succinopolysaccharide is 0.05:1. Adjust the pH of the solution to 8.0 and react at 40°C for 3 hours.

[0046] Step 3: After the reaction is complete, adjust the pH of the solution to neutral (pH=7.0), and perform dialysis using a dialysis bag with a molecular weight cutoff of 1000 Da for 24 hours. Replace the deionized water every 4 hours to remove unreacted OSA and byproducts.

[0047] Step 4: Under stirring at 200 rpm, add lecithin as a dispersant to the dialyzed solution. The mass ratio of lecithin to succinosaccharide is 0.5:100.

[0048] Step 5: Spray dry the solution from Step 4 under the following conditions: inlet air temperature 120℃, outlet air temperature 70℃, and feed rate 5mL / min, to obtain solid hydrophobically modified succinopolysaccharide.

[0049] The preparation method of the anti-hair loss shampoo composition in this embodiment is as follows: Azelaic acid, succinosaccharide, vegetable oil, polyglycerol-6 octanoate, and tocopherol were mixed, heated to 70°C, and stirred until homogeneous to obtain the oil phase. D-panthenol, caffeine, and the first part of the arborvitae leaf extract were mixed with purified water (18% of the total amount of purified water) to obtain a water-polyol phase. Stir at 4000 rpm in a homogenizer, slowly add the oil phase to the water-polyol phase, and keep stirring for 5 minutes to form a uniform gel, ensuring that the gel is uniform and free of particles. While stirring at 2500 rpm in a homogenizer, a second portion of purified water (55% of the total amount of purified water) was slowly added in batches to the gel to form a nanoemulsion. At a stirring speed of 350 rpm, sodium hyaluronate was added to the third part of purified water (22% of the total amount of purified water) and stirred evenly. Then sodium lauroyl sarcosinate and sodium cocoyl glutamate were added and stirred for 25 minutes to fully dissolve them, thus obtaining the shampoo base. Slowly add xanthan gum to the fourth part of purified water (5% of the total amount of purified water) and disperse it for 15 minutes at 12,000 rpm using a high-speed disperser to ensure that the xanthan gum is completely dispersed and free of lumps, thus obtaining a xanthan gum solution. At a stirring speed of 350 rpm, the nanoemulsion was added to the shampoo base and stirred evenly, and then the xanthan gum solution was added and stirred evenly. Add flavoring and stir well; Adjust the pH to 6.0 using citric acid.

[0050] Example 2 The formulation of the anti-hair loss shampoo composition in this embodiment is as follows: Platycladus orientalis leaf extract: 5 parts by weight; Caffeine: 2 parts by weight; Azelaic acid: 1 part by weight; Succinyl polysaccharide: 3 parts by weight; D-Panthenol: 2.0 parts by weight; Sodium hyaluronate: 0.1 parts by weight; Sodium lauroyl sarcosinate: 5 parts by weight; Sodium cocoyl glutamate: 5 parts by weight; Xanthan gum: 0.2 parts by weight; Vegetable oil: 5 parts by weight; Polyglycerol-6 octanoate: 1.5 parts by weight; Tocopherol: 0.5 parts by weight; Fragrance: 0.1 parts by weight; Purified water: 70 parts by weight; Citric acid: 0.1 parts.

[0051] The hydrophobic modification treatment of succinosaccharide was the same as in Example 1.

[0052] The preparation method of the anti-hair loss shampoo composition in this embodiment is the same as that in Example 1.

[0053] Comparative Example 1 The formulation of the anti-hair loss shampoo composition in this embodiment is as follows: Platycladus orientalis leaf extract: 10 parts by weight; Caffeine: 5 parts by weight; Azelaic acid: 3 parts by weight; Succinyl polysaccharide: 6 parts by weight; D-Panthenol: 2.5 parts by weight; Sodium hyaluronate: 0.2 parts by weight; Sodium lauroyl sarcosinate: 8 parts by weight; Sodium cocoyl glutamate: 8 parts by weight; Xanthan gum: 0.2 parts by weight; Purified water: 50 parts by weight; Fragrance: 0.2 parts by weight; Citric acid: 0.1 parts by weight.

[0054] The succinyl polysaccharide in this comparative example was not hydrophobically treated.

[0055] The preparation method of the anti-hair loss shampoo composition in this embodiment is as follows: Azelaic acid, succinosaccharide, caffeine, and arborvitae leaf extract were mixed with purified water (30% of the total amount of purified water used in the first part) to obtain an active ingredient solution. Slowly add xanthan gum to the second part of purified water (10% of the total amount of purified water) and disperse it for 15 minutes at 12,000 rpm using a high-speed disperser to ensure that the xanthan gum is completely dispersed and free of lumps, thus obtaining a xanthan gum solution. Add D-panthenol and sodium hyaluronate to the remaining purified water and stir at 400 rpm for 5 minutes until well mixed. Then add sodium lauroyl sarcosinate and sodium cocoyl glutamate and stir at 400 rpm for 20 minutes until fully dissolved to obtain the shampoo base. Add the active ingredient solution to the shampoo base at a stirring speed of 400 rpm and stir until homogeneous; Add xanthan gum solution and stir well; Add flavoring and stir well; Adjust the pH to 6.0 using citric acid.

[0056] Comparative Example 2 The formulation of the anti-hair loss shampoo composition in this comparative example is the same as that in Example 1, except that the succinopolysaccharide is not hydrophobically treated.

[0057] The preparation method of the anti-hair loss shampoo composition in this embodiment is as follows: Vegetable oil, polyglycerol-6 octanoate, and tocopherol were mixed to obtain the oil phase; Azelaic acid, succinosaccharide, caffeine, and arborvitae leaf extract were mixed with purified water (30% of the total amount of purified water used in the first part) to obtain the aqueous phase. The oil phase was slowly added to the aqueous phase, and the mixture was stirred at 10,000 rpm for 10 minutes at 70°C to perform preliminary emulsification and obtain a preliminary emulsion. The initial emulsion was homogenized using a high-pressure homogenizer at a pressure of 100 MPa for four times to obtain a nanoemulsion. Slowly add xanthan gum to the second part of purified water (10% of the total amount of purified water) and disperse it for 15 minutes at 12,000 rpm using a high-speed disperser to ensure that the xanthan gum is completely dispersed and free of lumps, thus obtaining a xanthan gum solution. Add D-panthenol and sodium hyaluronate to the remaining purified water and stir at 400 rpm for 5 minutes until well mixed. Then add sodium lauroyl sarcosinate and sodium cocoyl glutamate and stir at 400 rpm for 20 minutes until fully dissolved to obtain the shampoo base. Add the nano-emulsion to the shampoo base at a stirring speed of 400 rpm and stir until homogeneous; Add xanthan gum solution and stir well; Add flavoring and stir well; Adjust the pH to 6.0 using citric acid.

[0058] The anti-hair loss shampoo compositions of Examples 1-2 and Comparative Examples 1-2 were subjected to performance tests.

[0059] 1. Stability test: The anti-hair loss shampoo compositions of Examples 1-2 and Comparative Examples 1-2 were placed in constant temperature incubators at 4℃, 25℃, and 45℃, respectively. The appearance changes of the samples at different temperatures were observed, and phenomena such as layering, precipitation, and discoloration were recorded. The results are shown in Table 1 and... Figure 1 As shown. Figure 1 In the diagram, the top left image corresponds to the effect of storing Example 1 at 45°C for 3 months, the top right image corresponds to the effect of storing Example 2 at 45°C for 3 months, the bottom left image corresponds to the effect of storing Comparative Example 1 at 45°C for 1 month, and the bottom right image corresponds to the effect of storing Comparative Example 2 at 45°C for 1 month.

[0060] Table 1

[0061] As can be seen from Table 1, the shampoo composition prepared using the formulation and process of this embodiment has good stability.

[0062] 2. Cleaning ability test Referring to GB / T 29679-2013, the physicochemical properties of the anti-hair loss shampoo compositions of Examples 1-2, specifically the foam (40℃) / mm, were determined. The test results are shown in Table 2 and... Figure 2 As shown. Figure 2 In the diagram, the left image corresponds to Example 1, and the right image corresponds to Example 2.

[0063] Table 2

[0064] As can be seen from Table 2, the cleaning ability of the anti-hair loss shampoo compositions of Examples 1-2 meets the standard requirements.

[0065] 3. Anti-hair loss performance test Volunteer Grouping: Thirty male volunteers (men experiencing hair loss), aged 30-40, were recruited. The product from Example 1 was used. The volunteers' hair length was between 3-10 cm. Volunteers did not wash their hair the day before the test, but washed it on the first day of the test, and then every other day thereafter. The amount of hair loss and localized hair density were monitored, and data were collected every 4 weeks, with a test cycle of 20 weeks. In each test, the amount of hair loss was calculated using the 60-comb method, and localized hair density was assessed and recorded in a selected area.

[0066] After 20 weeks, all volunteers showed a significant reduction in the amount of hair loss and a significant increase in localized hair density: the average number of hairs lost before use was 15, and the average localized hair density before use was 120 hairs / cm². 3 After use, the average number of hairs lost was 11, and the average local hair density was 129 hairs / cm². 3 .

[0067] The data for one of the male volunteers, A, is shown in Table 3. Figure 3 The left image is a comparison of the hair of this volunteer before (i.e., the initial stage) and after 20 weeks (i.e., the fifth month) of use.

[0068] Table 3

[0069] The data for one of the male volunteers, B, is shown in Table 4. Figure 3 The image on the right is a comparison of the hair of this volunteer before (i.e., the initial stage) and after 20 weeks (i.e., the fifth month) of use.

[0070] Table 4

[0071] The data above shows that the product using the embodiments of this application does indeed have a significant effect on alleviating hair loss and increasing local hair density.

[0072] All volunteers were invited to rate their user experience with the product described in this application embodiment. The rating results are shown in Table 5. The rating items included: (1) No irritation to the scalp during shampooing: 1-5 points; the stronger the irritation, the lower the score; the lower the irritation, the higher the score.

[0073] (2) Significant reduction in hair loss after use: 1-5 points; the less the reduction, the lower the score; the more the reduction, the higher the score.

[0074] (3) New fine hairs are visible: 1-5 points; the fewer new hairs, the lower the score; the more new hairs, the higher the score.

[0075] (4) Improvement of scalp oiliness: 1-5 points; the lower the degree of improvement, the lower the score; the better the improvement of scalp oiliness, the higher the score.

[0076] Table 5

[0077] As can be seen from Table 5, the volunteers were quite satisfied with the product's experience and effects in this embodiment. Furthermore, the rating results also reflect the product's effectiveness in relieving hair loss from the user's subjective perspective.

[0078] It should be understood that the application of this application is not limited to the examples above. Those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of this application.

Claims

1. An anti-hair loss shampoo composition, characterized in that, By weight, it includes the following ingredients: Platycladus orientalis leaf extract: 5-15 parts by weight; Caffeine: 2-8 parts by weight; Azelaic acid: 1-5 parts by weight; Succinyl polysaccharide: 3-10 parts by weight; D-Panthenol: 1.5-3.5 parts by weight; Sodium hyaluronate: 0.1-0.3 parts by weight; Sodium lauroyl sarcosinate: 5-10 parts by weight; Sodium cocoyl glutamate: 5-10 parts by weight; Fragrance: 0.1-0.3 parts by weight; Purified water: 30-80 parts by weight; Xanthan gum: 0.2-0.5 parts by weight; Vegetable oil: 5-10 parts by weight; Polyglycerol-6 octanoate: 1.5-3 parts by weight; Tocopherol: 0.5-2 parts by weight; The succinyl polysaccharide has undergone hydrophobic modification treatment; The hydrophobic modification process of the succinyl polysaccharide includes the following steps: Step 1: Dissolve the succinyl polysaccharide in deionized water to prepare a succinyl polysaccharide solution; Step 2: Under stirring conditions, add octenyl succinic anhydride to the succinyl polysaccharide solution, adjust the pH value to 8.0-8.5, and react at 35-45℃ for 2.5-3.5 hours; Step 3: After the reaction is complete, adjust the pH of the solution to neutral and dialyze. Step 4: Under stirring conditions, add lecithin to the dialyzed solution and disperse it evenly; Step 5: Spray dry the solution from step 4 to obtain solid hydrophobic modified succinopolysaccharide.

2. The anti-hair loss shampoo composition according to claim 1, characterized in that, The anti-hair loss shampoo composition, by weight, further includes the following ingredients: Fragrance: 0.1-0.3 parts by weight.

3. The anti-hair loss shampoo composition according to claim 1, characterized in that, The anti-hair loss shampoo composition, by weight, further includes the following ingredients: Citric acid or sodium hydroxide: 0.01-2 parts; The pH of the anti-hair loss shampoo composition is adjusted to between 5.5 and 6.5 using either the citric acid or the sodium hydroxide.

4. The anti-hair loss shampoo composition according to claim 1, characterized in that, The mass ratio of octenyl succinic anhydride to succinopolysaccharide is 0.02-0.08:1, and the mass ratio of lecithin to succinopolysaccharide is 0.4-0.6:

100.

5. The anti-hair loss shampoo composition according to claim 1, characterized in that, In step 1, the mass concentration of the succinyl polysaccharide solution is 5%.

6. The anti-hair loss shampoo composition according to claim 1, characterized in that, In step 3, dialysis is performed using a dialysis bag with a molecular weight cutoff of 1000 Da for 24 hours, with the deionized water being replaced every 4 hours.

7. The anti-hair loss shampoo composition according to claim 1, characterized in that, In step 5, the spray drying conditions are: inlet air temperature 120°C, outlet air temperature 70°C, and feed rate 5 mL / min.

8. A method for preparing an anti-hair loss shampoo composition according to any one of claims 1-7, characterized in that, Includes the following steps: Azelaic acid, succinosaccharide, vegetable oil, polyglycerol-6 octanoate and tocopherol are mixed, heated to 70-75℃ and stirred until homogeneous to obtain the oil phase; D-panthenol, caffeine and the first part of purified water of the arborvitae leaf extract were mixed to obtain a water-polyol phase; The oil phase is added to the water-polyol phase and stirred in a homogenizer at a speed of 3000-5000 rpm for 5-10 minutes to obtain a gel. The mixture is stirred at 2000-3000 rpm in the homogenizer, and a second portion of purified water is added to the gel to form a nanoemulsion. Add sodium hyaluronate to the purified water in the third part at a stirring speed of 300-400 rpm, stir well, then add sodium lauroyl sarcosinate and sodium cocoyl glutamate, stir for 20-30 minutes to obtain the shampoo base. Add xanthan gum to the purified water in the fourth part and disperse it using a high-speed disperser at a speed of 10,000-12,000 rpm for 15-20 minutes to obtain a xanthan gum solution. At a stirring speed of 300-400 rpm, the nanoemulsion is added to the shampoo base and stirred evenly, and then the xanthan gum solution is added and stirred evenly. The first part of purified water accounts for 15-20% of the total amount of purified water, the second part accounts for 50-60% of the total amount of purified water, the third part accounts for 13-32% of the total amount of purified water, and the fourth part accounts for 3-7% of the total amount of purified water.

9. The method for preparing the anti-hair loss shampoo composition according to claim 8, characterized in that, It also includes the following steps: Add flavoring and stir well; Adjust the pH to 5.5-6.5 using citric acid or sodium hydroxide.

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