Continuous crystallization and purification equipment and process for sodium cromoglycate

Abstract

The invention relates to the technical field of continuous crystallization and purification of sodium cromoglycate, and provides continuous crystallization and purification equipment and a continuous crystallization and purification process of sodium cromoglycate, the continuous crystallization and purification equipment comprises a preheater body, a first crystallizer body, a centrifugal separator body, a cleaning machine body and a second crystallizer body which are communicated in sequence, and the continuous crystallization and purification equipment further comprises a driving motor, an assembly cylinder, an embedded plate and a stirring paddle plate. When a sodium cromoglycate solution in the crystallizer is stirred and mixed through the stirring paddle plate, the sodium cromoglycate solution can be prevented from being attached and crystallized on the surface of the stirring paddle plate by supplying heating gas into the assembly cylinder, and the sodium cromoglycate solution is heated through the stirring paddle plate, so that fine crystals in crystal slurry are completely dissolved, and only part of larger crystals are dissolved; more growth space and supersaturation degree are provided for residual crystals, and the sodium cromoglycate solution is continuously cooled and crystallized through the crystallizer, so that the average particle size of the product is increased, the crystallization effect of the crystallizer is improved, and the use is convenient.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of continuous crystallization purification of cromolyn sodium, and particularly relates to a continuous crystallization purification equipment and process for cromolyn sodium. BACKGROUND

[0002] Cromolyn sodium is an important anti-allergic drug, and the purity and crystal form of cromolyn sodium are crucial to drug efficacy and bioavailability. Compared with traditional batch crystallization, continuous crystallization has significant advantages such as stable product properties, high production efficiency, low operating cost, and easy automation, and is the development direction of modern pharmaceutical industry.

[0003] In the conventional continuous crystallization purification process of cromolyn sodium, the solution needs to be preheated, crystallized, centrifuged, washed, and recrystallized. The preheating is mainly used to preheat the crude cromolyn sodium solution to ensure that all the cromolyn sodium is completely dissolved to form an unsaturated or nearly saturated clear solution. The crystallization and recrystallization reactions are usually carried out by mixing and cooling the solution in a crystallizer to form a crystal slurry. After solid-liquid separation by a centrifugal separator, the crystals are washed by a washing machine, and the solution is recrystallized. Through two-step crystallization, crystals with more uniform purity and particle size are formed. However, since the crystallizer needs to be stirred during the crystallization reaction, the formed crystals may adhere to the outside of the stirring paddle during the cooling crystallization of the solution in the crystallizer. Since the crystals adhering to the stirring paddle can significantly reduce the stirring efficiency and destroy the uniformity of the flow field in the tank, the crystallization process is affected. Therefore, the present application proposes a continuous crystallization purification equipment and process for cromolyn sodium to solve the above problems. SUMMARY

[0004] Therefore, the present application provides a continuous crystallization purification equipment and process for cromolyn sodium to solve the technical problem that the formed crystals may adhere to the outside of the stirring paddle during the cooling crystallization of the solution in the crystallizer, which can significantly reduce the stirring efficiency and destroy the uniformity of the flow field in the tank, affecting the crystallization process.

[0005] The technical scheme of the present application is as follows: The present application provides a continuous crystallization purification equipment for cromolyn sodium, which comprises a preheater body, a first crystallizer body, a centrifugal separator body, a washing machine body, and a second crystallizer body connected in sequence, and further comprises a driving motor, an assembly cylinder, an embedded plate, and a stirring paddle.

[0006] The structures of the first crystallizer body and the second crystallizer body are adapted to each other. The preheater body is used to preheat the crude sodium cromoglycate solution. Both the first crystallizer body and the second crystallizer body are used to crystallize the sodium cromoglycate solution. The centrifuge body is used to perform solid-liquid separation on the sodium cromoglycate crystal slurry. The cleaning machine body is used to clean the sodium cromoglycate crystals.

[0007] Two drive motors are mounted on the first crystallizer body and the second crystallizer body, and the assembly cylinder is fixedly connected to the output shaft of the drive motor. The two assembly cylinders are located inside the first crystallizer body and the second crystallizer body, respectively, and the assembly cylinder is a hollow cylinder.

[0008] Multiple inner panels are disposed on the periphery of the assembly cylinder, and the periphery of the assembly cylinder is provided with a first vent hole that communicates with the inner cavity of the inner panel, and the periphery of the inner panel is provided with a hollow hole.

[0009] A stirring plate is fixedly sleeved on the outside of the inner plate and is used to stir the crude sodium cromoglycate solution inside the first crystallizer body or the second crystallizer body. The stirring plate is a heat-conducting plate.

[0010] Based on the above technical solutions, the preferred embodiment also includes an intake guide ring, a heating gas inlet pipe, and a sealing clamp, wherein...

[0011] An air intake guide ring is fixedly sleeved on the periphery of the assembly cylinder, and a connecting ring hole is provided on the top of the air intake guide ring. A second vent hole is provided on the assembly cylinder that communicates with the inner cavity of the air intake guide ring.

[0012] A heating gas inlet pipe passes through the connecting ring hole and extends into the interior of the inlet guide ring. The heating gas inlet pipe is used to connect to an external heating gas supply pipeline.

[0013] Two sealing clamps are both disposed on the periphery of the heating gas inlet pipe and located on the upper and lower sides of the top wall of the inlet guide ring, sealing and rotating with the inlet guide ring.

[0014] Based on the above technical solutions, the preferred embodiment also includes an inner ring body and a cooling coil, wherein...

[0015] Two inner ring bodies are respectively disposed inside the first crystallizer body and the second crystallizer body, with the stirring plate located inside the inner ring body. A spiral-shaped embedding groove is formed on the inner sidewall of the inner ring body.

[0016] A cooling coil is disposed inside the embedded groove, and the peripheral wall of the cooling coil extends out of the embedded groove for cooling the crude sodium cromoglycate solution inside the inner ring.

[0017] Based on the above technical solutions, preferably, it also includes a side-lead-out connecting plate and a heating jacket, wherein...

[0018] A side-lead-out connecting plate is a hollow, heat-conducting arched plate, which is set on one side of the inner ring body. Two mounting holes are opened on the inner ring body, and the two ends of the side-lead-out connecting plate pass through the mounting holes and are connected to the inner cavity of the inner ring body.

[0019] A heating jacket is fitted over the outside of the side lead-out connecting plate and is used to heat the side lead-out connecting plate.

[0020] Based on the above technical solutions, the preferred embodiment also includes an installation box, a top cover, and a filter screen, wherein...

[0021] The preheater body is connected to a second discharge pipe and a solution inlet pipe. The second discharge pipe is connected to the first crystallizer body. The second discharge pipe includes a first connecting pipe and a second connecting pipe.

[0022] The mounting box is a rectangular box, which is disposed between the first connecting pipe and the second connecting pipe, and the first connecting pipe and the second connecting pipe are respectively connected to the opposite sides of the mounting box.

[0023] The top opening of the mounting box, and the upper cover is detachably connected to the top of the mounting box, covering the top opening of the mounting box;

[0024] The filter screen is fixedly connected to the upper cover and covers the inlet of the second connecting pipe, used to filter large-volume impurities.

[0025] Based on the above technical solutions, a preferred embodiment also includes a lower cap, wherein...

[0026] The mounting box has a bottom opening, and the lower cover is detachably connected to the bottom of the mounting box, covering the bottom opening of the mounting box.

[0027] Based on the above technical solutions, a preferred embodiment also includes an anti-backflow limiting cone plate, wherein...

[0028] The anti-backflow limiting cone plate is a frustoconical plate, which is disposed inside the mounting box, and the first connecting pipe is connected to the inner side of the anti-backflow limiting cone plate.

[0029] Based on the above technical solutions, the preferred embodiment further includes a filter screen, a material guide block, and a water guide block, wherein...

[0030] The cleaning machine body is connected to a fourth discharge pipe, a drain pipe, and a rinsing water inlet pipe. The fourth discharge pipe is connected to the second crystallizer body.

[0031] A water filter screen is installed inside the main body of the cleaning machine and is sealed to the inner wall of the main body of the cleaning machine. The drain pipe is connected to the bottom of the water filter screen.

[0032] Two guide blocks are both located inside the main body of the washing machine and above the filter screen. They are sealed to the inner wall of the main body of the washing machine and the filter screen. The opposite side of the two guide blocks is an inclined surface, and the inclined surface of the guide blocks extends to the fourth discharge pipe.

[0033] A water guide block is installed on the top wall of the inner cavity of the cleaning machine body, and the bottom wall of the water guide block is an arc-shaped wall. The rinsing water inlet pipe is connected to the top side of the cleaning machine body and is used to discharge water towards the arc-shaped wall of the water guide block.

[0034] Based on the above technical solutions, the preferred embodiment also includes a baffle plate and an electrically operated telescopic component, wherein...

[0035] The fourth discharge pipe is a rectangular pipe, and a connection hole is provided at the top of the fourth discharge pipe. The baffle plate is slidably connected to the inside of the connection hole and is used to slide to block the fourth discharge pipe.

[0036] An electric telescopic component is provided on one side of the washing machine body, and the telescopic end of the electric telescopic component is fixedly connected to the baffle plate.

[0037] This invention also proposes a continuous crystallization purification process for sodium cromoglycate, which is completed using the aforementioned continuous crystallization purification equipment for sodium cromoglycate, and includes the following steps:

[0038] S1. Supply the crude sodium cromoglycate solution to the preheater body and heat the crude sodium cromoglycate solution to T1 through the preheater body, where 60℃≤T1≤70℃.

[0039] S2. The preheated sodium cromoglycate solution is supplied to the first crystallizer body, and the sodium cromoglycate solution is cooled and crystallized by the first crystallizer body, and the temperature of the sodium cromoglycate solution is reduced to T2, 30℃≤T2≤40℃, and heating gas is supplied into the assembly cylinder at the same time.

[0040] S3. The crystal slurry generated by the first crystallizer body is supplied to the centrifugal separator body, and the crystal slurry is separated into solid and liquid by the centrifugal separator body;

[0041] S4. The crystals produced after separation by the centrifugal separator are supplied to the cleaning machine body, and the crystals are rinsed by the cleaning machine body.

[0042] S5. Mix the rinsed crystals with pure solvent and then slurry them, and supply the slurry to the second crystallizer body.

[0043] S6. The slurry is subjected to secondary crystallization through the second crystallizer body.

[0044] The sodium cromoglycate continuous crystallization purification equipment and process of the present invention have the following advantages over the prior art:

[0045] (1) The sodium cromoglycate continuous crystallization purification equipment of this application can also heat the sodium cromoglycate solution in the crystallizer by stirring and mixing the sodium cromoglycate solution in the crystallizer through the stirring plate, and by supplying heating gas into the assembly cylinder and heating the stirring plate through the first vent and the inner plate. This allows the stirring plate to heat the sodium cromoglycate solution simultaneously during the stirring and mixing process. By heating the stirring plate, the sodium cromoglycate solution is prevented from adhering to the surface of the stirring plate and crystallizing. By heating the sodium cromoglycate solution through the stirring plate, the small crystals in the crystal slurry are completely dissolved, while the larger crystals are only partially dissolved, providing more growth space and supersaturation for the remaining crystals. The sodium cromoglycate solution is continuously cooled and crystallized in the crystallizer, thereby increasing the average particle size of the product, improving the crystallization effect of the crystallizer, and making it convenient to use.

[0046] (2) The preheated solution discharged through the preheater body needs to pass through the installation box, which is detachably connected to an upper cover. This allows the filter screen connected to the upper cover to be detachably connected to the installation box. After the upper cover is connected, the filter screen can naturally block the second connecting pipe, filtering out large-volume impurities in the solution flowing through the installation box. The filtered large-volume impurities accumulate inside the installation box, making it easy to clean by opening the installation box. When the filter screen needs to be replaced or maintained, only the upper cover needs to be removed to replace or maintain the removed filter screen. The rectangular shape of the installation box facilitates the connection of the filter screen.

[0047] (3) By setting up guide blocks and water guide blocks, specifically after the centrifugal separator supplies the crystals to the cleaning machine body, the crystals are stored above the filter screen. A flushing water inlet pipe is connected to the top side of the cleaning machine body and flows out towards the bottom wall of the water guide block. The bottom wall of the water guide block is an arc-shaped wall. Under the guidance of the bottom wall of the water guide block, the flushing water discharged from the flushing water inlet pipe has a circumferential flow tendency. The rotating flushing water can more easily flush the crystals in all directions. By setting the opposite side walls of the two guide blocks to be inclined walls, the crystals can be collected at the fourth discharge pipe under the action of the flushing water. After the crystals are flushed, the fourth discharge pipe can be opened to discharge the crystals, which is convenient for use. At the same time, by setting a drain pipe connected to the bottom of the filter screen, the flushing water is discharged through the drain pipe, so that the cleaning machine body can continuously maintain water with a high degree of cleanliness to flush the crystals, thereby improving the flushing effect of the crystals. Attached Figure Description

[0048] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0049] Figure 1 This is a perspective view of the sodium cromoglycate continuous crystallization purification apparatus of the present invention;

[0050] Figure 2 This is a perspective view of the first crystallizer body of the sodium cromoglycate continuous crystallization purification apparatus of the present invention;

[0051] Figure 3 This is a schematic diagram of the internal structure of the first crystallizer body of the sodium cromoglycate continuous crystallization purification device of the present invention;

[0052] Figure 4 The sodium cromoglycate continuous crystallization purification device of the present invention Figure 3 A bottom-view perspective of the structure shown.

[0053] Figure 5 This is a cross-sectional schematic diagram of the first crystallizer body of the sodium cromoglycate continuous crystallization purification device of the present invention;

[0054] Figure 6 The sodium cromoglycate continuous crystallization purification device of the present invention Figure 5 An enlarged view of point A is shown below;

[0055] Figure 7 The sodium cromoglycate continuous crystallization purification device of the present invention Figure 5 An enlarged view of point B is shown below;

[0056] Figure 8 This is a perspective view of the preheater body of the sodium cromoglycate continuous crystallization purification device of the present invention;

[0057] Figure 9 This is a cross-sectional schematic diagram of the structure of the mounting box of the sodium cromoglycate continuous crystallization purification device of the present invention;

[0058] Figure 10 This is a perspective view of the cleaning machine body of the sodium cromoglycate continuous crystallization purification equipment of the present invention;

[0059] Figure 11 This is a schematic diagram of the internal structure of the cleaning machine body of the sodium cromoglycate continuous crystallization purification equipment of the present invention;

[0060] Figure 12 This is a cross-sectional schematic diagram of the cleaning machine body of the sodium cromoglycate continuous crystallization purification equipment of the present invention.

[0061] In the diagram: 11. First crystallizer body; 111. First discharge pipe; 12. Second crystallizer body; 13. Preheater body; 131. Second discharge pipe; 1311. First connecting pipe; 1312. Second connecting pipe; 132. Solution inlet pipe; 14. Centrifuge body; 141. Third discharge pipe; 15. Washing machine body; 151. Fourth discharge pipe; 152. Drain pipe; 153. Rinse water inlet pipe; 21. Drive motor; 22. Assembly cylinder; 221. First vent; 222. Second vent; 2 3. Inner plate; 231. Hollow hole; 24. Stirring plate; 25. Air inlet guide ring; 251. Connecting ring hole; 26. Heating gas inlet pipe; 27. Sealing clamp; 31. Inner ring body; 311. Embedded groove; 312. Mounting hole; 32. Cooling coil; 41. Side lead-out connecting plate; 42. Heating jacket; 51. Mounting box; 52. Upper cover; 53. Lower cover; 54. Filter screen; 55. Anti-backflow limiting cone plate; 6. Water filter screen; 71. Material guide block; 72. Water guide block; 81. Material baffle plate; 82. Electric telescopic component. Detailed Implementation

[0062] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0063] like Figures 1-12As shown, the sodium cromoglycate continuous crystallization purification device of the present invention includes a preheater body 13, a first crystallizer body 11, a centrifuge body 14, a washing machine body 15, and a second crystallizer body 12 connected in sequence. It also includes a drive motor 21, an assembly cylinder 22, an inner plate 23, and a stirring plate 24. The structures of the first crystallizer body 11 and the second crystallizer body 12 are adapted to each other. The preheater body 13 is used to preheat the crude sodium cromoglycate solution. Both the first crystallizer body 11 and the second crystallizer body 12 are used to crystallize the sodium cromoglycate solution. The centrifuge body 14 is used for solid-liquid separation of the sodium cromoglycate crystal slurry. The washing machine body 15 is used to wash the sodium cromoglycate crystals. The two drive motors 21, 22, 23, and 24 are connected in sequence. The drive motor 21 is mounted on the first crystallizer body 11 and the second crystallizer body 12, and the assembly cylinder 22 is fixedly connected to the output shaft of the drive motor 21. The two assembly cylinders 22 are located inside the first crystallizer body 11 and the second crystallizer body 12, respectively. The assembly cylinder 22 is a hollow cylinder. Multiple inner plates 23 are all arranged on the periphery of the assembly cylinder 22, and the periphery of the assembly cylinder 22 is provided with a first vent hole 221 that communicates with the inner cavity of the inner plate 23. The periphery of the inner plate 23 is provided with a hollow hole 231. The stirring plate 24 is fixedly sleeved on the outside of the inner plate 23 and is used to stir the crude sodium cromoglycate solution in the first crystallizer body 11 or the second crystallizer body 12. The stirring plate 24 is a heat-conducting plate.

[0064] In specific implementation, the preheater body 13 is connected to a solution inlet pipe 132 and is connected to the first crystallizer body 11 through a second discharge pipe 131. The first crystallizer body 11 and the second crystallizer body 12 are both connected to a first discharge pipe 111. The first discharge pipe 111 on the first crystallizer body 11 is connected to the centrifuge body 14. The first discharge pipe 111 on the second crystallizer body 12 is used to discharge crystal slurry. The centrifuge body 14 is connected to the washing machine body 15 through a third discharge pipe 141. The third discharge pipe 141 is used to discharge the crystals separated by the centrifuge body 14. The washing machine body 15 is connected to the second crystallizer body 12 through a fourth discharge pipe 151.

[0065] In specific implementation, a crude sodium cromoglycate solution is supplied to the preheater body 13, and the preheater body 13 heats the crude sodium cromoglycate solution to T1, where 60℃≤T1≤70℃. The preheated sodium cromoglycate solution is then supplied to the first crystallizer body 11, where the first crystallizer body 11 cools and crystallizes the sodium cromoglycate solution, lowering its temperature to T2, where 30℃≤T1≤40℃. Simultaneously, heating gas is supplied into the assembly cylinder 22. At this time, the heating gas is supplied to the inner plate 23 through the first vent 221, and heats the stirring plate 24 through the perforated holes 231 of the inner plate 23. The drive motor 21 starts synchronously, and drives the stirring plate 24 through the assembly cylinder 22 to stir, mix and heat the sodium cromoglycate solution in the crystallizer; the crystal slurry generated by the first crystallizer body 11 is supplied to the centrifuge body 14, and the centrifuge body 14 performs solid-liquid separation on the crystal slurry; the crystals generated after separation by the centrifuge body 14 are supplied to the cleaning machine body 15, and the crystals are washed by the cleaning machine body 15; the washed crystals are mixed with pure solvent and then slurried again, and the slurried crystal slurry is supplied to the second crystallizer body 12; the crystal slurry is subjected to secondary crystallization by the second crystallizer body 12.

[0066] The sodium cromoglycate continuous crystallization purification equipment of this application, while stirring and mixing the sodium cromoglycate solution in the crystallizer using the stirring plate 24, can also supply heating gas into the assembly cylinder 22, heating the stirring plate 24 through the first vent 221 and the inner plate 23. This allows the stirring plate 24 to simultaneously heat the sodium cromoglycate solution during stirring and mixing. Heating the stirring plate 24 prevents the sodium cromoglycate solution from adhering to the surface of the stirring plate 24 and crystallizing. Heating the sodium cromoglycate solution with the stirring plate 24 completely dissolves the fine crystals in the crystal slurry, while only partially dissolving the larger crystals, providing more growth space and supersaturation for the remaining crystals. By continuously cooling and crystallizing the sodium cromoglycate solution in the crystallizer, the average particle size of the product is increased, the crystallization effect of the crystallizer is improved, and the equipment is convenient to use.

[0067] In a preferred embodiment, the system further includes an air inlet guide ring 25, a heating gas inlet pipe 26, and sealing clamps 27. The air inlet guide ring 25 is fixedly sleeved on the periphery of the assembly cylinder 22, and a connecting ring hole 251 is provided on the top of the air inlet guide ring 25. A second vent hole 222 communicating with the inner cavity of the air inlet guide ring 25 is provided on the assembly cylinder 22. The heating gas inlet pipe 26 passes through the connecting ring hole 251 and extends into the interior of the air inlet guide ring 25. The heating gas inlet pipe 26 is used to connect to an external heating gas supply pipeline. The two sealing clamps 27 are both provided on the periphery of the heating gas inlet pipe 26 and are located on the upper and lower sides of the top wall of the air inlet guide ring 25, sealing and rotatingly connected to the air inlet guide ring 25.

[0068] In practice, heating gas is supplied to the air inlet guide ring 25 through the heating gas inlet pipe 26, and the air inlet guide ring 25 supplies air to the assembly cylinder 22 through the second vent 222, thus completing the supply of heating gas. The air inlet guide ring 25 facilitates the assembly of the heating gas inlet pipe 26, and the sealing clamp 27 ensures that the air inlet guide ring 25 remains connected to the heating gas inlet pipe 26 during rotation, thereby ensuring that the heating gas inlet pipe 26 continuously supplies air to the rotating assembly cylinder 22, making it convenient to use.

[0069] In a preferred embodiment, the system further includes an inner ring body 31 and a cooling coil 32. The two inner ring bodies 31 are respectively disposed inside the first crystallizer body 11 and the second crystallizer body 12, and the stirring plate 24 is located inside the inner ring body 31. A spiral-shaped embedding groove 311 is provided on the inner side wall of the inner ring body 31. The cooling coil 32 is disposed inside the embedding groove 311, and the peripheral wall of the cooling coil 32 extends out of the embedding groove 311 for cooling the crude sodium cromoglycate solution inside the inner ring body 31.

[0070] In practice, sodium cromoglycate solution is stored inside the inner ring 31. The sodium cromoglycate solution is cooled and crystallized by the cooling coil 32. By setting an embedded groove 311 extending from the peripheral wall of the cooling coil 32, the cooling coil 32 can directly contact the sodium cromoglycate solution, thereby improving the cooling effect on the sodium cromoglycate solution.

[0071] It also includes a side lead-out connecting plate 41 and a heating jacket 42. The side lead-out connecting plate 41 is a hollow heat-conducting arched plate, which is set on one side of the inner ring body 31. The inner ring body 31 has two mounting holes 312, and both ends of the side lead-out connecting plate 41 pass through the mounting holes 312 and communicate with the inner cavity of the inner ring body 31. The heating jacket 42 is sleeved on the outside of the side lead-out connecting plate 41 and is used to heat the side lead-out connecting plate 41.

[0072] In practice, when the sodium cromoglycate solution is stirred and mixed by the stirring plate 24, a portion of the rotating sodium cromoglycate solution can be discharged into the interior of the side-exit connecting plate 41 through the mounting hole 312. The sodium cromoglycate solution flowing through the side-exit connecting plate 41 is heated by the heating jacket 42, causing the fine crystals in the flowing sodium cromoglycate solution to completely dissolve, while the larger crystals only partially dissolve. This design provides more growth space and supersaturation for the remaining crystals, thereby increasing the average particle size of the product and facilitating its use.

[0073] In a preferred embodiment, the device further includes a mounting box 51, an upper cover 52, and a filter screen 54. The preheater body 13 is connected to a second discharge pipe 131 and a solution inlet pipe 132. The second discharge pipe 131 is connected to the first crystallizer body 11 and includes a first connecting pipe 1311 and a second connecting pipe 1312. The mounting box 51 is a rectangular box, positioned between the first connecting pipe 1311 and the second connecting pipe 1312, with the first connecting pipe 1311 and the second connecting pipe 1312 respectively connected to opposite sides of the mounting box 51. The mounting box 51 has an opening at the top, and the upper cover 52 is detachably connected to the top of the mounting box 51, covering the opening. The filter screen 54 is fixedly connected to the upper cover 52 and covers the inlet of the second connecting pipe 1312, used to filter large-volume impurities.

[0074] The preheated solution discharged through the preheater body 13 needs to pass through the installation box 51. A detachable upper cover 52 is connected to the installation box 51, allowing the filter screen 54 connected to the upper cover 52 to be detachably connected to the installation box 51. Thus, after the upper cover 52 is connected, the filter screen 54 can naturally block the second connecting pipe 1312, filtering out large-volume impurities in the solution flowing through the installation box 51. The filtered large-volume impurities accumulate inside the installation box 51, making it easy to clean by opening the installation box 51. When the filter screen 54 needs to be replaced or maintained, simply remove the upper cover 52 to replace or maintain the removed filter screen 54. The rectangular shape of the installation box 51 facilitates the connection and processing of the filter screen 54.

[0075] It also includes a lower cover 53, wherein the bottom opening of the mounting box 51 is provided, and the lower cover 53 is detachably connected to the bottom of the mounting box 51 to cover the bottom opening of the mounting box 51.

[0076] This design allows the lower cover 53 to be removed when it is necessary to remove impurities accumulated inside the mounting box 51, making it convenient to use.

[0077] It also includes a backflow prevention limiting cone plate 55, wherein the backflow prevention limiting cone plate 55 is a frustoconical plate, which is set inside the mounting box 51, and the first connecting pipe 1311 is connected to the inner side of the backflow prevention limiting cone plate 55.

[0078] In practice, a material drop gap is formed between the anti-backflow limiting cone plate 55 and the filter screen 54. Under the restriction of the anti-backflow limiting cone plate 55, the falling impurities can be effectively prevented from flowing back into the interior of the first connecting pipe 1311.

[0079] In a preferred embodiment, the system further includes a water filter screen 6, a material guide block 71, and a water guide block 72. The washing machine body 15 is connected to a fourth discharge pipe 151, a drain pipe 152, and a rinsing water inlet pipe 153. The fourth discharge pipe 151 is connected to the second crystallizer body 12. The water filter screen 6 is disposed inside the washing machine body 15 and is sealed to the inner wall of the washing machine body 15. The drain pipe 152 is connected below the water filter screen 6. Both material guide blocks 71 are disposed within the washing machine body. Inside the main body 15, and above the filter screen 6, it is sealed to the inner wall of the main body 15 and the filter screen 6. The opposite sides of the two guide blocks 71 are inclined surfaces, and the inclined surfaces of the guide blocks 71 extend to the fourth discharge pipe 151. The water guide block 72 is set on the top wall of the inner cavity of the main body 15, and the bottom wall of the water guide block 72 is an arc-shaped wall. The rinsing water inlet pipe 153 is connected to the top side of the main body 15 and is used to discharge water towards the arc-shaped wall of the water guide block 72.

[0080] By setting up guide blocks 71 and water guide blocks 72, specifically after the centrifugal separator body 14 supplies crystals to the cleaning machine body 15, the crystals are stored above the water filter screen 6. A rinsing water inlet pipe 153 is set to connect to the top side of the cleaning machine body 15 and the water flows out towards the bottom wall of the water guide block 72. The bottom wall of the water guide block 72 is an arc-shaped wall. Under the guidance of the bottom wall of the water guide block 72, the rinsing water discharged from the rinsing water inlet pipe 153 has a circumferential flow tendency. The rotating rinsing water can more easily rinse the crystals from all directions. By setting the opposite side walls of the two guide blocks 71 to be inclined walls, the crystals can be collected at the fourth discharge pipe 151 under the action of the rinsing water. After the crystals are rinsed, the fourth discharge pipe 151 can be opened to discharge the crystals, which is convenient for use. Meanwhile, by setting a drain pipe 152 connected to the bottom of the filter screen 6, the rinsing water is discharged through the drain pipe 152, so that the cleaning machine body 15 can continuously maintain water with a high degree of cleanliness to rinse the crystal, thereby improving the rinsing effect on the crystal.

[0081] It also includes a baffle plate 81 and an electric telescopic component 82. The fourth discharge pipe 151 is a rectangular tube, and a connection hole is opened at the top of the fourth discharge pipe 151. The baffle plate 81 is slidably connected to the inside of the connection hole and is used to slide to block the fourth discharge pipe 151. The electric telescopic component 82 is set on one side of the washing machine body 15, and the telescopic end of the electric telescopic component 82 is fixedly connected to the baffle plate 81.

[0082] Preferably, the electric telescopic component 82 is an electric telescopic rod.

[0083] In practice, the crystals stored inside the cleaning machine body 15 are blocked by the baffle plate 81. When it is necessary to discharge the crystals, the electric telescopic component 82 is adjusted to retract, and the electric telescopic component 82 drives the baffle plate 81 to move upward, opening the fourth discharge pipe 151, thereby allowing the crystals to be discharged from the fourth discharge pipe 151. By setting the fourth discharge pipe 151 as a rectangular tube, it is convenient to assemble the baffle plate 81.

[0084] This invention also proposes a continuous crystallization purification process for sodium cromoglycate, which is completed using the aforementioned continuous crystallization purification equipment for sodium cromoglycate, and includes the following steps:

[0085] Step 1: Supply the crude sodium cromoglycate solution to the preheater body 13, and heat the crude sodium cromoglycate solution to T1 through the preheater body 13, where 60℃≤T1≤70℃;

[0086] Step 2: The preheated sodium cromoglycate solution is supplied to the first crystallizer body 11. The sodium cromoglycate solution is cooled and crystallized by the first crystallizer body 11, and the temperature of the sodium cromoglycate solution is reduced to T2, 30℃≤T2≤40℃. Simultaneously, heating gas is supplied into the assembly cylinder 22. At this time, the heating gas is supplied to the inner plate 23 through the first vent 221 and heated through the hollow hole 231 of the inner plate 23. The drive motor 21 is started simultaneously, and the assembly cylinder 22 drives the stirring plate 24 to stir, mix and heat the sodium cromoglycate solution in the crystallizer.

[0087] Step 3: The crystal slurry generated by the first crystallizer body 11 is supplied to the centrifuge body 14, and the crystal slurry is separated into solid and liquid by the centrifuge body 14.

[0088] Step 4: The crystals produced after separation by the centrifuge body 14 are supplied to the cleaning machine body 15, and the crystals are rinsed by the cleaning machine body 15.

[0089] Step 5: Mix the rinsed crystals with pure solvent and then slurry them, and supply the slurry to the second crystallizer body 12;

[0090] Step 6: The crystal slurry is subjected to secondary crystallization through the second crystallizer body 12.

[0091] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A continuous crystallization purification device for sodium cromoglycate, characterized in that: The system includes a preheater body, a first crystallizer body, a centrifuge body, a cleaning machine body, and a second crystallizer body connected in sequence. It also includes a drive motor, an assembly cylinder, an inner plate, and a stirring plate. The structures of the first crystallizer body and the second crystallizer body are adapted to each other. The preheater body is used to preheat the crude sodium cromoglycate solution. Both the first crystallizer body and the second crystallizer body are used to crystallize the sodium cromoglycate solution. The centrifuge body is used to perform solid-liquid separation on the sodium cromoglycate crystal slurry. The cleaning machine body is used to clean the sodium cromoglycate crystals. Two drive motors are mounted on the first crystallizer body and the second crystallizer body, and the assembly cylinder is fixedly connected to the output shaft of the drive motor. The two assembly cylinders are located inside the first crystallizer body and the second crystallizer body, respectively, and the assembly cylinder is a hollow cylinder. Multiple inner panels are disposed on the periphery of the assembly cylinder, and the periphery of the assembly cylinder is provided with a first vent hole that communicates with the inner cavity of the inner panel, and the periphery of the inner panel is provided with a hollow hole. A stirring plate is fixedly sleeved on the outside of the inner plate and is used to stir the crude sodium cromoglycate solution inside the first crystallizer body or the second crystallizer body. The stirring plate is a heat-conducting plate.

2. The sodium cromoglycate continuous crystallization purification equipment as described in claim 1, characterized in that: It also includes an intake guide ring, a heating air inlet pipe, and a sealing clamp, among which, An air intake guide ring is fixedly sleeved on the periphery of the assembly cylinder, and a connecting ring hole is provided on the top of the air intake guide ring. A second vent hole is provided on the assembly cylinder that communicates with the inner cavity of the air intake guide ring. A heating gas inlet pipe passes through the connecting ring hole and extends into the interior of the inlet guide ring. The heating gas inlet pipe is used to connect to an external heating gas supply pipeline. Two sealing clamps are both disposed on the periphery of the heating gas inlet pipe and located on the upper and lower sides of the top wall of the inlet guide ring, sealing and rotating with the inlet guide ring.

3. The sodium cromoglycate continuous crystallization purification equipment as described in claim 1, characterized in that: It also includes the inner ring and cooling coils, among which, Two inner ring bodies are respectively disposed inside the first crystallizer body and the second crystallizer body, with the stirring plate located inside the inner ring body. A spiral-shaped embedding groove is formed on the inner sidewall of the inner ring body. A cooling coil is disposed inside the embedded groove, and the peripheral wall of the cooling coil extends out of the embedded groove for cooling the crude sodium cromoglycate solution inside the inner ring.

4. The sodium cromoglycate continuous crystallization purification equipment as described in claim 3, characterized in that: It also includes a side-exit connecting plate and a heating jacket, wherein, A side-lead-out connecting plate is a hollow, heat-conducting arched plate, which is set on one side of the inner ring body. Two mounting holes are opened on the inner ring body, and the two ends of the side-lead-out connecting plate pass through the mounting holes and are connected to the inner cavity of the inner ring body. A heating jacket is fitted over the outside of the side lead-out connecting plate and is used to heat the side lead-out connecting plate.

5. The sodium cromoglycate continuous crystallization purification equipment as described in claim 1, characterized in that: It also includes a mounting box, a top cover, and a filter, among which, The preheater body is connected to a second discharge pipe and a solution inlet pipe. The second discharge pipe is connected to the first crystallizer body. The second discharge pipe includes a first connecting pipe and a second connecting pipe. The mounting box is a rectangular box, which is disposed between the first connecting pipe and the second connecting pipe, and the first connecting pipe and the second connecting pipe are respectively connected to the opposite sides of the mounting box. The top opening of the mounting box, and the upper cover is detachably connected to the top of the mounting box, covering the top opening of the mounting box; The filter screen is fixedly connected to the upper cover and covers the inlet of the second connecting pipe, used to filter large-volume impurities.

6. The sodium cromoglycate continuous crystallization purification equipment as described in claim 5, characterized in that: It also includes the lower cap, among which, The mounting box has a bottom opening, and the lower cover is detachably connected to the bottom of the mounting box, covering the bottom opening of the mounting box.

7. The sodium cromoglycate continuous crystallization purification equipment as described in claim 6, characterized in that: It also includes a backflow prevention limiting cone plate, among which, The anti-backflow limiting cone plate is a frustoconical plate, which is disposed inside the mounting box, and the first connecting pipe is connected to the inner side of the anti-backflow limiting cone plate.

8. The sodium cromoglycate continuous crystallization purification equipment as described in claim 1, characterized in that: It also includes a filter screen, a feed guide block, and a water guide block, among which, The cleaning machine body is connected to a fourth discharge pipe, a drain pipe, and a rinsing water inlet pipe. The fourth discharge pipe is connected to the second crystallizer body. A water filter screen is installed inside the main body of the cleaning machine and is sealed to the inner wall of the main body of the cleaning machine. The drain pipe is connected to the bottom of the water filter screen. Two guide blocks are both located inside the main body of the washing machine and above the filter screen. They are sealed to the inner wall of the main body of the washing machine and the filter screen. The opposite side of the two guide blocks is an inclined surface, and the inclined surface of the guide blocks extends to the fourth discharge pipe. A water guide block is installed on the top wall of the inner cavity of the cleaning machine body, and the bottom wall of the water guide block is an arc-shaped wall. The rinsing water inlet pipe is connected to the top side of the cleaning machine body and is used to discharge water towards the arc-shaped wall of the water guide block.

9. The sodium cromoglycate continuous crystallization purification equipment as described in claim 8, characterized in that: It also includes baffles and electrically operated telescopic components, among which, The fourth discharge pipe is a rectangular pipe, and a connection hole is provided at the top of the fourth discharge pipe. The baffle plate is slidably connected to the inside of the connection hole and is used to slide to block the fourth discharge pipe. An electric telescopic component is provided on one side of the washing machine body, and the telescopic end of the electric telescopic component is fixedly connected to the baffle plate.

10. A continuous crystallization purification process for sodium cromoglycate, characterized in that: The purification process is completed using the sodium cromoglycate continuous crystallization purification apparatus according to any one of claims 1 to 9, and includes the following steps: S1. Supply the crude sodium cromoglycate solution to the preheater body and heat the crude sodium cromoglycate solution to T1 through the preheater body, where 60℃≤T≤70℃. S2. The preheated sodium cromoglycate solution is supplied to the first crystallizer body, and the sodium cromoglycate solution is cooled and crystallized by the first crystallizer body, and the temperature of the sodium cromoglycate solution is reduced to T2, 30℃≤T≤40℃, and heating gas is supplied into the interior of the assembly cylinder at the same time. S3. The crystal slurry generated by the first crystallizer body is supplied to the centrifugal separator body, and the crystal slurry is separated into solid and liquid by the centrifugal separator body; S4. The crystals produced after separation by the centrifugal separator are supplied to the cleaning machine body, and the crystals are rinsed by the cleaning machine body. S5. Mix the rinsed crystals with pure solvent and then slurry them, and supply the slurry to the second crystallizer body. S6. The slurry is subjected to secondary crystallization through the second crystallizer body.

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