Antibacterial healing-promoting ostomy bag lining based on nano-silver-hydrogel composite material

Abstract

The invention provides an antibacterial healing-promoting ostomy bag lining based on a nano-silver-hydrogel composite material, and relates to the technical field of medical instruments, the antibacterial healing-promoting ostomy bag lining comprises a protective layer, a functional layer, a working layer and a contact layer which are sequentially connected from bottom to top, the outer surface of the protective layer is fixedly connected with an ostomy bag main body, and the outer surface of the functional layer is fixedly connected with the ostomy bag main body; the protective layer is made of a polyurethane material; the functional layer is made of cross-linked sodium carboxymethyl cellulose hydrogel, and a plurality of nano-silver particles are embedded in the functional layer; the working layer is prepared from methacrylic acid-co-acrylamide; the contact layer is made of a chitosan-hyaluronic acid composite material. The problems that an ostomy bag lining in the prior art is poor in adaptability to complex wound exudate, poor in use comfort, poor in antibacterial effect after being worn for a long time and hinders tissue regeneration are solved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to an antibacterial and healing-promoting ostomy bag liner based on a nano-silver-hydrogel composite material. Background Technology

[0002] An ostomy bag is a medical device used to collect human excrement, primarily for patients after ostomy surgery. Existing technology discloses a patent titled "An Ostomy Bag Lining Structure for Absorbing Intestinal Fluid," publication number CN214967442U. While this structure can collect items, it has poor adaptability to exudates from complex wounds in practical applications. Furthermore, for patients requiring long-term wear, its antibacterial effect is poor, and it hinders tissue regeneration, thus affecting patient comfort and wound healing efficiency. Summary of the Invention

[0003] The purpose of this invention is to provide an antibacterial and healing-promoting ostomy bag liner based on nano-silver-hydrogel composite material, which solves the problems of existing ostomy bag liners, such as poor adaptability to complex wound exudates, poor comfort, poor antibacterial effect during long-term wear, and hindering tissue regeneration.

[0004] The technical solution of the present invention:

[0005] This invention provides an antibacterial and healing-promoting ostomy bag liner based on a nano-silver-hydrogel composite material, comprising: a protective layer, a functional layer, a working layer, and a contact layer connected sequentially from bottom to top, wherein: the outer surface of the protective layer is fixedly connected to the main body of the ostomy bag, and the protective layer is made of polyurethane material; the functional layer is made of cross-linked sodium carboxymethyl cellulose hydrogel with embedded nano-silver particles; the working layer is made of methacrylic acid-co-acrylamide; and the contact layer is made of chitosan-hyaluronic acid composite material.

[0006] Furthermore, the outer surface of the protective layer is fixedly connected to the ostomy bag body by a hot-pressing process; the functional layer is fixedly connected to the protective layer by a covalent grafting method; the functional layer forms a chemical bond with the hydroxyl groups on the surface of the working layer through a free radical polymerization reaction; and the working layer is connected to the contact layer by an electrostatic self-assembly method.

[0007] Furthermore, the protective layer has a pore size of 100–300 μm and a porosity of 65%–75%; the protective layer has a thickness of 0.4–0.7 mm, the functional layer has a thickness of 0.8–1.2 mm, and the working layer has a thickness of 0.15–0.25 mm.

[0008] Furthermore, the outer surface of the protective layer is connected with a plurality of positioning protrusions, the diameter of the positioning protrusions being 0.5 mm, and the plurality of positioning protrusions being arranged in a rectangular array with a spacing of 5 mm.

[0009] Furthermore, the inner wall of the ostomy bag body is provided with a mating groove, and the positioning protrusion is fixedly connected to the mating groove.

[0010] Furthermore, an annular working groove is formed on the edge of the inner surface of the protective layer, the annular working groove having a depth of 0.3 mm and a width of 1.0 mm.

[0011] Furthermore, the bottom of the annular working groove is provided with several drainage holes, the diameter of which is 0.2 mm.

[0012] Furthermore, the outer surface of the protective layer has a liquid storage cavity, which is connected to the drainage hole and the drainage channel of the ostomy bag body.

[0013] Furthermore, the nano-silver particles have a particle size of 10–30 nm, and the nano-silver particles are in-situ reduced and embedded inside the cross-linked sodium carboxymethyl cellulose hydrogel by using sodium citrate as a reducing agent.

[0014] Furthermore, the contact layer has micropores, which are formed by freeze-drying.

[0015] Based on the above technical features, the beneficial effects of the present invention are as follows:

[0016] (1) The antibacterial and healing-promoting ostomy bag liner provided by the present invention is provided with a protective layer, a functional layer, a working layer and a contact layer. The functional layer enables the antibacterial components to be released stably during long-term use. The working layer enables on-demand antibacterial treatment. The contact layer can improve cell compatibility and tissue regeneration efficiency.

[0017] (2) The antibacterial and healing-promoting ostomy bag liner provided by the present invention, through the combination of hot pressing process, covalent grafting method, chemical bonding and electrostatic self-assembly connection method, can ensure that even under repeated aspiration, release and circulation and patient movement deformation, the protective layer, functional layer, working layer and contact layer will not delaminate or slip, thereby ensuring the continuity of effective use.

[0018] (3) The antibacterial and healing-promoting ostomy bag liner provided by the present invention can effectively prevent interface peeling caused by the accumulation of exudate through the setting of the annular working groove, drainage hole, liquid storage cavity and drainage channel. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the structure of the present invention.

[0021] In the diagram: 1. Protective layer; 2. Functional layer; 3. Working layer; 4. Contact layer; 5. Positioning protrusions; 6. Annular working groove; 7. Drainage hole; 8. Liquid storage chamber. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0023] The following detailed description of embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0024] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0025] In the description of this invention, it should be noted that if terms such as "upper" or "lower" are used to indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the product is usually placed in during use, they are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0026] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0027] Example 1

[0028] Please refer to Figure 1 The present invention provides an antibacterial and healing-promoting ostomy bag liner based on a nano-silver-hydrogel composite material. The structure includes, from bottom to top, a protective layer 1, a functional layer 2, a working layer 3, and a contact layer 4, wherein: the outer surface of the protective layer 1 is fixedly connected to the ostomy bag body, and the protective layer 1 is made of polyurethane material; the functional layer 2 is made of cross-linked sodium carboxymethyl cellulose hydrogel and has embedded a number of nano-silver particles therein; the working layer 3 is made of methacrylic acid-co-acrylamide; and the contact layer 4 is made of chitosan-hyaluronic acid composite material.

[0029] It should be noted that the liner provided in this embodiment of the invention comprises a protective layer 1, a functional layer 2, a working layer 3, and a contact layer 4. Specifically, the protective layer 1 protects the entire liner and connects and fixes it to the ostomy bag body. Furthermore, the protective layer 1 is a membrane structure made of porous polyurethane material, which is elastic and adapts to the patient's movements, reducing the risk of leakage, improving patient comfort, blocking leakage of excrement, and allowing water vapor from the patient's skin to pass through, preventing the wound area from becoming hot and damp, thus reducing the probability of skin maceration and infection. This makes the structure more adaptable to complex wound exudates and provides better antibacterial effects with long-term wear. The functional layer 2 absorbs wound exudate. The functional layer 2 is made of cross-linked sodium carboxymethyl cellulose hydrogel, allowing it to expand after absorbing wound exudate while controlling the volume expansion rate to 170%. This ensures that the functional layer 2 maintains structural integrity while preventing detachment from the wound due to excessive expansion. The working layer 3 remains highly elastic at the patient's body temperature (approximately 37°C), maintaining flexibility and deformability to adapt to changes in the wound's contour. The contact layer 4, made of chitosan-hyaluronic acid composite material, contacts the patient's skin. Hyaluronic acid promotes cell migration and proliferation, providing a suitable microenvironment for tissue repair-related cells such as fibroblasts and endothelial cells, facilitating effective cell migration and proliferation, and laying the foundation for tissue regeneration. Chitosan induces macrophage differentiation, further creating a stable environment for cell adhesion and proliferation. This allows the contact layer 4 to provide a biocompatible interface and promote cell behavior, thus promoting tissue regeneration during long-term wear. Specifically, the functional layer 2 is surrounded by the working layer 3, and the working layer 3 is surrounded by the contact layer 4. This invention can solve the problems of existing ostomy bag liners, which have poor adaptability to complex wound exudates, poor comfort, poor antibacterial effect when worn for a long time, and hinder tissue regeneration.

[0030] Example 2

[0031] Based on Example 1, an antibacterial and healing-promoting ostomy bag liner based on a nano-silver-hydrogel composite material is provided. Specifically, the outer surface of the protective layer 1 is fixedly connected to the main body of the ostomy bag via a hot-pressing process, resulting in a strong connection and good sealing performance, providing waterproofing and leak-proofing. The functional layer 2 is fixedly connected to the protective layer 1 via covalent grafting. Specifically, the functional layer 2 and the protective layer 1 are connected by covalent bonds. The functional layer 2 contains CMC-Na molecular chains, and the surface of the protective layer 1 has hydroxyl groups. After activation, the ends of the CMC-Na molecular chains form ester bonds with the hydroxyl groups. The functional layer 2 forms chemical bonds with the hydroxyl groups on the surface of the working layer 3 through a free radical polymerization reaction. Specifically, the working layer 3 and the functional layer 2 achieve chemical bonding through C-C bonds generated during the free radical polymerization process. The working layer 3 and the contact layer 4 are connected via electrostatic self-assembly. Specifically, the working layer 3 and the contact layer 4 are bonded by ionic bonds formed through electrostatic self-assembly.

[0032] Furthermore, the protective layer 1 has a pore size of 100–300 μm and a porosity of 65%–75%; the protective layer 1 has a thickness of 0.4–0.7 mm, preferably 0.5 mm; the functional layer 2 has a thickness of 0.8–1.2 mm, preferably 1.0 mm; and the working layer 3 has a thickness of 0.15–0.25 mm, preferably 0.2 mm.

[0033] Furthermore, the outer surface of the protective layer 1 is connected with several positioning protrusions 5, each with a diameter of 0.5 mm. These protrusions 5 are arranged in a rectangular array with a spacing of 5 mm. A mating groove is formed on the inner wall of the ostomy bag body, and the positioning protrusions 5 are fixedly connected to this groove. The positioning protrusions 5 are embedded in the mating groove, and the polyurethane material used in the protective layer 1 is partially melted and cooled to solidify using hot air welding. This permanently fixes the protective layer 1 to the inner wall of the ostomy bag body, ensuring the stability of the connection between the protective layer 1 and the ostomy bag body during long-term wear and preventing interface loosening due to exudate penetration. Optionally, the positioning protrusions 5 are cylindrical, preferably with a height of 0.3 mm.

[0034] Furthermore, an annular working groove 6 is formed on the edge of the inner surface of the protective layer 1. The annular working groove 6 has a depth of 0.3 mm and a width of 1.0 mm. Several drainage holes 7 are formed at the bottom of the annular working groove 6. The diameter of the drainage holes 7 is 0.2 mm. The outer surface of the protective layer 1 has a liquid storage cavity 8, which is a closed cavity formed by hot pressing. The liquid storage cavity 8 is connected to the drainage holes 7, that is, the drainage holes 7 penetrate the protective layer 1 and are connected to the liquid storage cavity 8. The liquid storage cavity 8 is connected to the drainage channel of the ostomy bag body. Optionally, the annular working groove 6 has a depth of 0.3 mm and a width of 1.0 mm. The number of drainage holes 7 is 3 per centimeter of length. The volume of the liquid storage cavity 8 is 0.8 cm³. A silicone valve is connected to the outlet of the liquid storage cavity 8. It can be opened unidirectionally under the strong action of the seepage pressure to realize the directional discharge of excess liquid and prevent the accumulation of liquid from causing interface separation.

[0035] Furthermore, the nanoparticles have a particle size of 10–30 nm, and are in-situ reduced and embedded within the cross-linked sodium carboxymethyl cellulose hydrogel using sodium citrate as a reducing agent. Specifically, the surface of the nanoparticles is modified with thioglycolic acid molecules. The slow oxidation and dissolution of the nanoparticles in functional layer 2 yields silver ions. The thioglycolic acid molecules on the surface of the nanoparticles form coordination bonds with the carboxyl groups in the cross-linked sodium carboxymethyl cellulose hydrogel, allowing the nanoparticles to be uniformly dispersed within the three-dimensional network of the cross-linked sodium carboxymethyl cellulose hydrogel. This effectively inhibits the aggregation and burst release of silver particles, ensuring long-term stable release.

[0036] Furthermore, the contact layer 4 has micropores, which are formed by freeze-drying.

[0037] It should be noted that the contact layer 4 is made of chitosan-hyaluronic acid composite material. The contact layer 4 is connected to the working layer 3. The micropores on the contact layer 4 form a capillary network, which rapidly absorbs liquid and forms a hydration layer on the membrane surface. The outermost layer of hyaluronic acid in the contact layer 4 has carboxyl groups on its molecular chain that dissociate and become negatively charged in the physiological environment. These carboxyl groups form an electrostatic attraction with the protonated amino groups remaining on the surface of the working layer 3, allowing the contact layer 4 to firmly cover the working layer 3 even in a wet state, preventing delamination due to hydration. At the same time, the RGD tripeptide sequence grafted onto the surface of the hyaluronic acid is exposed at the interface. The guanidinyl group of its arginine residues specifically recognizes and binds to the integrin receptor on the keratinocyte membrane, promoting initial cell adhesion and providing a molecular basis for subsequent epithelialization. In detail, hyaluronic acid has a strong water-retention capacity, which can keep the skin around the stoma moist and prevent dryness and aggravation of damage caused by excrement irritation. Chitosan has good adhesion, which can make the liner fit tightly against the stoma tissue, reduce secondary irritation of damaged tissue by excrement leakage, and thus maintain a moist and stable microenvironment in the stoma bag. On the other hand, chronic inflammation often occurs around the stoma due to foreign body irritation and mild infection. Persistent inflammation can hinder tissue regeneration. Hyaluronic acid can regulate the activity of inflammatory cells and reduce excessive inflammatory response. Chitosan can also alleviate local inflammation by regulating the expression of inflammation-related proteins, thereby reducing the inflammatory state at the stoma site and promoting tissue regeneration.

[0038] It should be noted that the working layer 3 is made of methacrylic acid-co-acrylamide. Methacrylic acid-co-acrylamide is sensitive to pH. Specifically, when the pH of the patient's wound is below 6.0 (i.e., infection or inflammation), the carboxyl group in methacrylic acid-co-acrylamide is protonated, which leads to enhanced hydrogen bonds between molecular chains. The network formed in the structure of methacrylic acid-co-acrylamide shrinks, and the pores decrease, thereby limiting the diffusion of silver ions from the nanoparticles in functional layer 2. When the pH is above 7.4 (i.e., the normal healing environment), the carboxyl group in methacrylic acid-co-acrylamide is deprotonated, which generates electrostatic repulsion. The network swells, the pores expand, and the release of silver ions from the nanoparticles in functional layer 2 is accelerated, which diffuses to the wound and can effectively inhibit the growth of Staphylococcus aureus and Escherichia coli.

[0039] It should be noted that one embodiment of the present invention is as follows: First, the positioning protrusion 5 is aligned and fitted with the mating groove, and then fixed by hot air welding. After the patient wears it, the contact layer 4 directly adheres to the wound surface around the stoma. The wound exudate first comes into contact with the micropores of the contact layer 4, and the exudate is quickly absorbed, wetting the chitosan-hyaluronic acid composite material to form a hydrophilic interface. Then, the water in the exudate further penetrates into the working layer 3, causing the methacrylic acid-co-acrylamide material to swell or shrink according to its pH value. For example, if there is an infection in the wound, p When pH drops to 5.8, the working layer 3 contracts, slowing down the diffusion of silver ions from the functional layer 2. For example, if the wound is in the normal healing stage and the pH is 7.6, the working layer 3 swells, opening the channels to allow the silver ions to be released continuously. At the same time, excess liquid in the exudate flows along the gap between the contact layer 4 and the wound to the edge of the liner, enters the annular working groove 6, and flows into the storage chamber 8 through the drainage hole 7. When the liquid pressure in the storage chamber 8 exceeds the opening threshold of the one-way silicone valve, the valve opens, and the liquid is discharged into the drainage channel of the ostomy bag body, avoiding local fluid accumulation that could cause the liner to lift or peel off.

[0040] Example 3

[0041] Based on Example 2, an antibacterial and healing-promoting ostomy bag liner based on a nano-silver-hydrogel composite material is provided. Specifically, the connection process between functional layer 2 and protective layer 1 involves first introducing active hydroxyl groups through plasma treatment on the inner surface of protective layer 1, then coating it with a cross-linked sodium carboxymethyl cellulose hydrogel precursor solution. The precursor solution contains 0.8 wt% CMC-Na, 0.05 wt% N,N'-methylenebisacrylamide cross-linking agent, and 0.02 wt% ammonium persulfate initiator. Subsequently, 0.01 M silver nitrate solution and 0.015 M sodium citrate solution are added, and the reaction is carried out in a 60°C water bath for 2 hours, thereby reducing silver ions in situ within the hydrogel network to generate nano-silver particles with a particle size of 10–30 nm. After the reaction is completed, the sample is vacuum dried at 60°C for 4 hours, and then placed in a pH 7.4 phosphate buffer for swelling equilibrium, thereby forming a cross-linking density of 8 × 10⁻⁻⁻⁻⁻⁶. 4 Functional layer 2 with mol / cm³.

[0042] In some embodiments, the connection process between the working layer 3 and the functional layer 2 specifically involves mixing methacrylic acid and acrylamide in a molar ratio of 40:60, adding 0.1 wt% azobisisobutyronitrile as an initiator, and dissolving the mixture in anhydrous ethanol to prepare a 10 wt% monomer solution; then immersing the functional layer 2 in the solution and reacting it at 70°C for 6 hours under nitrogen protection, so that the monomer polymerizes in situ on the surface of the functional layer 2, thereby forming the working layer 3. The molar proportion of methacrylic acid units in the working layer 3 is 40%, and its carboxyl groups undergo protonation or deprotonation transformation under different pH conditions.

[0043] In some embodiments, the connection process between the contact layer 4 and the working layer 3 specifically involves first immersing the working layer 3 in a 1 mg / mL chitosan solution (molecular weight 80 kDa, degree of deacetylation 92%, dissolved in 0.1 M acetic acid solution) for 10 minutes, then rinsing it with deionized water, and then immersing it in a 1 mg / mL hyaluronic acid solution (molecular weight 300 kDa, dissolved in deionized water) for 10 minutes, followed by rinsing again. This alternating deposition process is repeated for a total of five layers, resulting in an outermost layer of hyaluronic acid. After completion, the sample is placed in a −20°C environment and frozen at a rate of 5°C / min, and then freeze-dried under a vacuum of 10 Pa for 12 hours to form an interconnected honeycomb microporous structure with a pore size of 50–200 μm. Before freeze-drying, the RGD tripeptide is dissolved in a hyaluronic acid solution to a final concentration of 0.5 mg / mL, allowing the RGD sequence to be grafted onto the surface of the outermost hyaluronic acid membrane. The grafting density, measured by X-ray photoelectron spectroscopy, is 1.2 × 10¹³ molecules / cm². The contact layer 4 is bonded to the working layer 3 through electrostatic interaction. Its outermost layer of hyaluronic acid is negatively charged, which forms an electrostatic attraction with the protonated amino groups remaining on the surface of the working layer 3, thus achieving stable coverage.

[0044] It should be noted that the remaining structures are existing technologies and will not be discussed further here.

[0045] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the scope of the invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0046] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A nano-silver-hydrogel composite-based antibacterial and healing-promoting pouch inner liner, characterized in that, Comprise: From bottom to top, the protective layer (1), functional layer (2), working layer (3) and contact layer (4) are connected in turn, wherein: The outer surface of the protective layer (1) is fixedly connected with the ostomy bag body, and the protective layer (1) is made of polyurethane material; The functional layer (2) is made of cross-linked sodium carboxymethyl cellulose hydrogel and several nano silver particles are embedded in it; The working layer (3) is made of methacrylic acid-co-acrylamide; The contact layer (4) is made of chitosan-hyaluronic acid composite material.

2. The antimicrobial, pro-healing ostomy pouch inner liner according to claim 1, characterized in that, The outer surface of the protective layer (1) and the ostomy bag body are fixedly connected by hot pressing process; the functional layer (2) and the protective layer (1) are fixedly connected by covalent grafting; the functional layer (2) and the working layer (3) are chemically bonded through the hydroxyl groups on the surface of the working layer (3) by free radical polymerization reaction; the working layer (3) and the contact layer (4) are connected by electrostatic self-assembly.

3. The antimicrobial, pro-healing ostomy pouch inner liner according to claim 1, characterized in that, The pore size of the protective layer (1) is 100-300 μm, and the porosity is 65%-75%; the thickness of the protective layer (1) is 0.4-0.7 mm, the thickness of the functional layer (2) is 0.8-1.2 mm, and the thickness of the working layer (3) is 0.15-0.25 mm.

4. The antimicrobial, pro-healing ostomy pouch inner liner of claim 1, wherein, The outer surface of the protective layer (1) is connected with several positioning convex points (5), the diameter of the positioning convex points (5) is 0.5 mm, several positioning convex points (5) are arranged in rectangular array and the spacing is 5 mm.

5. The antimicrobial, pro-healing ostomy pouch inner liner according to claim 4, characterized in that, The inner wall of the ostomy bag body is provided with a matching groove, and the positioning convex points (5) and the matching groove are fixedly connected.

6. The antimicrobial, pro-healing ostomy pouch inner liner of claim 4, wherein, The edge of the inner surface of the protective layer (1) is provided with an annular working groove (6), and the depth of the annular working groove (6) is 0.3 mm and the width is 1.0 mm.

7. The antimicrobial, pro-healing ostomy pouch inner liner according to claim 6, characterized in that, The bottom of the annular working groove (6) is provided with several drainage holes (7), and the diameter of the drainage holes (7) is 0.2 mm.

8. The antimicrobial, pro-healing ostomy pouch inner liner according to claim 7, characterized in that, The outer surface of the protective layer (1) has a liquid storage cavity (8), the liquid storage cavity (8) communicates with the drainage hole (7), and the liquid storage cavity (8) communicates with the drainage channel of the ostomy bag body.

9. The antimicrobial, pro-healing ostomy pouch inner liner of claim 1, wherein, The particle size of the nano silver particles is 10-30 nm, and the nano silver particles are embedded in situ by sodium citrate as a reducing agent in the cross-linked sodium carboxymethyl cellulose hydrogel.

10. The antimicrobial, pro-healing ostomy pouch inner liner of claim 2, wherein, The contact layer (4) has micropores, and the micropores are formed by freeze-drying method.

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