Metal polyphenol nano-enzyme as well as preparation method and application thereof

By constructing a core-shell structured metal polyphenol nanozyme and utilizing Ce-TA co-loaded with RSV and a hybrid cell membrane, the problems of poor targeting, immune escape, and release controllability in existing technologies have been solved, achieving a highly efficient and safe treatment for inflammatory bowel disease.

CN121668192APending Publication Date: 2026-03-17GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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Patent Information

Application Number
CN202511906071.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-17
Publication Date
2026-03-17

AI Technical Summary

Technical Problem

Existing technologies for treating inflammatory bowel disease (IBD) suffer from limitations in targeting, insufficient immune escape, limited catalytic activity, and poor release controllability, resulting in low drug delivery efficiency, high toxicity risk, and difficulty in achieving drug concentrations at the lesion site.

Method used

The metal polyphenol nanozyme with a core-shell structure has a core of Ce-TA and RSV co-loaded nanoparticles and a shell of hybrid macrophage and neutrophil membranes. It utilizes Ce3+/Ce4+ valence state cycling and pH/ROS dual response release characteristics to achieve SOD-CAT cascade ROS clearance and RSV anti-inflammatory synergy, cross the mucus layer and epithelial barrier, prolong the circulating half-life and achieve controlled release.

Benefits of technology

It significantly enhances catalytic activity and targeting ability, prolongs drug circulation time in vivo, increases lesion enrichment, reduces toxicity risk, and achieves precise and controllable drug release at the site of inflammation, avoiding off-target toxicity.

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Abstract

The invention relates to a metal polyphenol nano-enzyme, the metal polyphenol nano-enzyme comprises a core and a shell, the core comprises cerium, tannic acid and resveratrol, the shell comprises a hybrid cell membrane, and the shell wraps the surface of the core. The preparation method of the metal polyphenol nano enzyme comprises the following steps: preparing metal polyphenol nano particles; and extraction of a hybrid cell membrane and integration of a core and a shell. The metal polyphenol nano-enzyme provided by the invention has the advantages that the catalytic activity and selectivity are remarkably improved, the targeting capability and focus enrichment are improved, and controllable release and safety are realized.
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