Preparation method of external traditional Chinese medicine liquid for treating synovitis osteoarthralgia
This topical Chinese medicine liquid, prepared using a specific formula and a low-temperature, long-term ethanol soaking process, solves the problems of complex formulas, risks of toxic medicinal materials, and unstable efficacy in existing topical Chinese medicine preparations for treating synovitis and joint pain. It achieves rapid pain relief and improved safety, and is suitable for a variety of joint pain symptoms.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-10
- Publication Date
- 2026-03-31
AI Technical Summary
Existing topical Chinese medicine preparations for treating synovitis and joint pain suffer from problems such as complex formulas, slow onset of action, the presence of unprocessed toxic herbs, simple and crude preparation processes leading to insufficient dissolution of active ingredients, and unsuitable dosage forms, resulting in unstable efficacy and high safety risks.
The formula uses eighteen kinds of Chinese medicinal herbs, including processed aconite, processed kusnezoffii, and processed strychnos nux-vomica, which are processed into principal herbs. Combined with insect-based medicinal materials such as black snake and centipede, the tincture is prepared by low-temperature long-term ethanol soaking and solid-liquid separation process. Borneol and peppermint are added as penetration enhancers to ensure stable efficacy and safety.
It achieves rapid relief of synovitis and joint pain, improves efficacy stability and safety, enhances transdermal absorption, is suitable for various joint pain symptoms, and maintains consistent quality between batches.
Abstract
Description
Technical Field
[0001] This invention relates to the field of traditional Chinese medicine external preparations, specifically a method for preparing an external traditional Chinese medicine liquid for treating synovitis and joint pain. Background Technology
[0002] Synovitis and various types of bone and joint pain are common and frequently occurring diseases in clinical practice. They are mostly caused by the invasion of wind-dampness and cold, chronic strain, trauma, or degenerative diseases, leading to poor local blood circulation and meridian obstruction. Modern medical treatment mainly involves oral non-steroidal anti-inflammatory drugs, local injections, or surgery. Although these can relieve symptoms, long-term use can easily cause side effects such as gastrointestinal, liver, and kidney damage, and they are difficult to cure completely with a high recurrence rate.
[0003] Traditional Chinese medicine (TCM) external treatment has unique advantages in treating such diseases. By administering medication through the skin, it acts directly on the lesion, avoiding the first-pass effect of the liver and reducing systemic side effects. While various TCM liniments and plasters exist, they generally suffer from the following problems: First, their formulas are complex, resulting in slow onset of action and limited effectiveness for acute or deep tissue pain; second, some formulas contain unprocessed toxic herbs (such as raw aconite, raw kusnezoffii, and raw strychnos nux-vomica), posing significant safety risks; third, the preparation process is simple and crude, such as short-term soaking in liquor, leading to insufficient dissolution of active ingredients, unstable efficacy, and large batch-to-batch variations; fourth, the dosage forms are unsuitable, with some products having high viscosity, making them difficult to apply and absorb, or their volatile components are easily lost. Summary of the Invention
[0004] To address the shortcomings of existing technologies, this invention provides a method for preparing a topical Chinese medicine liquid for treating synovitis and joint pain. This method solves several problems: existing formulas are complex, slow-acting, and have limited effectiveness for acute or deep tissue pain; some formulas contain unprocessed toxic herbs (such as raw aconite, raw kusnezoffii, and raw strychnos nux-vomica), posing significant safety risks; the preparation process is simple and crude, such as short-term soaking in white wine, resulting in insufficient dissolution of active ingredients and unstable efficacy with large batch-to-batch variations; and the dosage form is unsuitable, with some products having high viscosity, making them difficult to apply and absorb, or volatile components easily dissipating.
[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain, comprising the following steps: (1) Raw material pretreatment: Take eighteen kinds of Chinese medicinal materials, including black snake, prepared aconite, prepared aconite root, angelica pubescens, prepared pinellia, eucommia bark, achyranthes root, salvia miltiorrhiza, safflower, earthworm, centipede, horseweed, lycopodium, clematis root, prepared strychnos nux-vomica, roasted rhubarb, borneol, and mint. Mix them, wash and dry them. (2) Pulverization: Pulverize the Chinese medicinal materials mixture after drying in step (1) and pass it through a 60-100 mesh sieve to obtain Chinese medicinal powder; (3) Ethanol soaking: The Chinese herbal powder is mixed with baijiu with an alcohol content of 50-65 degrees and placed in a sealed container. It is soaked at 10-30℃ for 12-25 days, and stirred regularly during the period to obtain the original medicinal wine containing the dregs; wherein the mass-volume ratio of the Chinese herbal powder to the baijiu is 1:4-1:10 (kg / L). (4) Solid-liquid separation: The original medicinal wine is filtered to separate and obtain a clear medicinal liquid; (5) Packaging: The clarified medicinal liquid is filled into a pharmaceutical packaging container and sealed to obtain the finished external Chinese medicine liquid.
[0006] Preferably, in step (1), the eighteen Chinese medicinal materials, by mass parts, include: 5-15 parts of black-spotted snake, 3-10 parts of processed aconite root, 3-10 parts of processed aconite root, 10-20 parts of angelica pubescens, 5-12 parts of processed pinellia tuber, 10-20 parts of eucommia bark, 10-20 parts of achyranthes bidentata, 10-25 parts of salvia miltiorrhiza, 5-15 parts of safflower, 5-15 parts of earthworm, 1-5 parts of centipede, 10-25 parts of horseweed, 10-25 parts of lycopodium clavatum, 10-25 parts of clematis chinensis, 1-5 parts of processed strychnos nux-vomica, 5-15 parts of roasted rhubarb, 1-5 parts of borneol, and 5-15 parts of peppermint.
[0007] Preferably, in step (1), the drying is performed at 40-60°C until the moisture content is less than 12%.
[0008] Preferably, in step (3), the alcohol content of the liquor is 53-62 degrees; the soaking temperature is 18-25℃; and the soaking time is 14-20 days.
[0009] Preferably, in step (3), the soaking process is stirred once every 2-5 days, for 5-15 minutes each time.
[0010] Preferably, in step (3), the mass-to-volume ratio of the traditional Chinese medicine powder to the liquor is 1:5-1:8 (kg / L).
[0011] Preferably, in step (4), the filtration is performed using 80-200 mesh filter cloth, filter bag, or plate and frame filter.
[0012] Preferably, in step (5), the pharmaceutical packaging container is a brown glass bottle, and the filling volume of each bottle is 30-60 mL; more preferably, the filling volume of each bottle is 50 mL.
[0013] Preferably, in step (5), after dispensing, nitrogen is filled into the packaging container to replace the top air, and then it is sealed.
[0014] This formula uses processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Strychnos nux-vomica (all processed to reduce toxicity) as the principal herbs, which have strong effects in warming the meridians, dispelling cold, eliminating wind and dampness, and relieving pain. It uses insect-derived herbs such as Zaocys dhumnades, centipedes, and earthworms as assistant herbs to dispel wind, clear the meridians, attack toxins, and dissipate nodules. It uses Angelica pubescens, Lycopodium clavatum, Clematis chinensis, and Smilax china to dispel wind and dampness, relax muscles and tendons, and promote blood circulation. It uses Salvia miltiorrhiza, Carthamus tinctorius, Achyranthes bidentata, and processed rhubarb to invigorate blood, remove blood stasis, and guide blood downwards. It uses Eucommia ulmoides and Achyranthes bidentata to tonify the liver and kidneys and strengthen muscles and bones. It uses processed Pinellia ternata to dry dampness, resolve phlegm, and dissipate nodules. It uses borneol and peppermint for their pungent and aromatic properties, guiding the medicine through the skin and providing cooling and pain relief. The entire formula integrates warming, clearing, invigorating, dampness-removing, and skin-penetrating effects, working together to warm the meridians, dispel cold, eliminate wind and dampness, clear the meridians, relieve pain, and invigorate blood and remove blood stasis. All toxic herbs in the formula have been processed according to regulations, ensuring relative safety for external use. Beneficial effects This invention provides a method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain. The formula targets the core pathogenesis of "wind-cold-dampness arthralgia and blood stasis obstructing the collaterals," selecting potent insect-derived medicines for unblocking collaterals and relieving pain, and aconite and strychnine-derived herbs for dispelling wind and cold. Combined with blood-activating and transdermal components, it can rapidly relieve pain and improve joint function. The aconite, kusnezoffii, strychnine, and pinellia in the formula are all processed ("processed"), and their toxic components (such as aconitine and strychnine) are partially transformed or reduced during processing. Under strict control of the dosage and scope of external application, the safety of the medication is greatly improved. The process of "low-temperature drying-co-pulverization-long-term constant-temperature cold soaking" avoids the loss of volatile components and the destruction of heat-sensitive components caused by decoction. The soaking time of 14-20 days, combined with intermittent stirring, ensures the full dissolution of alcohol-soluble and fat-soluble active ingredients, resulting in stable batch-to-batch quality. The prepared traditional Chinese medicine liquid is a tincture with good fluidity, easy to apply and massage, and can cover a large painful area. Alcohol helps drugs penetrate the skin barrier and reach the affected area directly. After evaporation, it leaves no sticky residue. It is not only suitable for synovitis, but also has good efficacy for various types of rheumatic, degenerative, and traumatic bone and joint pain, and has a wide range of clinical indications. Detailed Implementation
[0015] The present invention will be further described in detail below through specific embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of the invention.
[0016] Example 1: A method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain. The method includes the following steps: 1. Raw material preparation and pretreatment Formula and weighing: Strictly weigh the following eighteen Chinese medicinal herbs according to their quality requirements: Black-tailed snake: 100 g Processed Aconitum carmichaelii: 60 g Prepared Aconitum carmichaelii: 60 g Angelica pubescens: 150 g Prepared Pinellia: 80 g Eucommia ulmoides: 150 g Achyranthes bidentata: 150 g Danshen: 180 g Safflower: 100 g Earthworm: 100 g Centipede: 30 g 180 g of horse sedge Lycopodium album: 180 g Clematis armandii: 180 g Processed Strychnos nux-vomica: 30 g Roasted rhubarb: 100 g Borneol: 30 g Peppermint: 100 g Cleaning: Place the weighed mixed herbs in a clean stainless steel sieve and rinse quickly 2-3 times with running room temperature drinking water to remove surface dust, then drain. Avoid prolonged soaking, which may cause the loss of water-soluble components.
[0017] Drying: Spread the drained medicinal materials evenly on a stainless steel drying tray, with a thickness not exceeding 3 cm. Place the tray in a forced convection hot air circulating oven, set the temperature to 55℃ ± 2℃, and continue drying for 8-10 hours. Turn the tray over every 2 hours to ensure even drying. The drying endpoint is achieved when the moisture content of the medicinal materials is ≤ 10% (which can be measured using a rapid moisture analyzer). After drying, the total weight of the medicinal materials will be reduced to approximately 1580 g (estimated).
[0018] 2. Mixing and grinding All the dried mixed medicinal materials are put into the hopper of the high-efficiency universal pulverizer.
[0019] Start the crusher and crush for about 5-8 minutes until all the material passes through an 80-mesh standard sieve.
[0020] Collect all the powder and weigh approximately 1500 g (due to moisture evaporation and grinding losses). The powder should be a uniform brownish-yellow to brownish-brown color, without any visible coarse particles or fibers.
[0021] 3. Ethanol soaking extraction Solvent preparation: Prepare 53% vol pure grain liquor that meets food standards, totaling approximately 7500 mL (approximately 6 kg).
[0022] Feeding and mixing: Transfer 1500 g of Chinese herbal powder to a 20 L wide-mouthed brown glass jar with a lid. Slowly add the prepared white wine while stirring with a clean glass rod until the powder is completely submerged and a uniform suspension is formed.
[0023] Sealing and Labeling: Tighten the glass jar lid to ensure a good seal. Affix a label to the outside of the jar, indicating the raw material batch number and the soaking start date (year / month / day).
[0024] Immersion conditions control: Place the sealed glass jar in a temperature-controlled indoor environment with a constant ambient temperature of 22℃±2℃, and ensure that the place is dark, dry and well-ventilated.
[0025] Process Management: The total soaking period is 18 days. During this period, stir the container every 72 hours (i.e., every 3 days): gently shake the glass jar for 2-3 minutes, or open the lid and stir it up and down 10 times with a clean stirring rod to resuspend the settled powder. Reseal immediately after each operation.
[0026] 4. Solid-liquid separation Preliminary filtration: After the soaking period, prepare a 300-mesh nylon filter cloth and a clean receiving container. Slowly pour all the material in the glass jar (including the supernatant and precipitate) onto the prepared filter cloth for filtration.
[0027] Pressing: After most of the liquid has been filtered out, wrap the filter cloth together with the medicine residue and place it in a small press. Press it for 5 minutes with appropriate pressure (about 0.2 MPa) to fully squeeze out the residual medicine liquid adsorbed in the medicine residue.
[0028] Fine filtration: The combined liquid obtained from the initial filtration and pressing is then filtered again through a 500-mesh filter bag to further remove any fine particles, resulting in a clear, transparent, dark brownish-red liquid. The final volume is approximately 6800 mL.
[0029] 5. Finished product repackaging and packaging Dispensing preparation: Perform the operation in a clean bench or Class D clean area. Use 50 mL brown screw-top glass bottles (soda-lime glass, meeting pharmaceutical packaging standards) and matching plastic screw caps lined with polyester film. All packaging materials should be pre-cleaned, dried, and UV sterilized.
[0030] Quantitative filling: A liquid quantitative filling machine is used, with the filling volume set to 50.0 mL ± 0.5 mL. The finely filtered medicine solution is then filled.
[0031] Inert gas protection: Before tightening the cap, briefly purge each bottle opening with high-purity nitrogen (purity ≥99.99%) for about 1-2 seconds to displace the air at the top of the bottle.
[0032] Sealing and Labeling: Immediately tighten the cap to ensure a tight seal. Affix a label to the bottle indicating the product name, batch number, specifications, production date, expiration date, and warning information such as "For external use only, do not ingest."
[0033] Packaging: Pack the finished bottles into cardboard boxes and store them in a cool (not exceeding 20℃), dry, and light-proof finished product warehouse.
[0034] Example 2: A method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain. The method includes the following steps: 1. Raw material preparation and pretreatment The formulation, weighing, cleaning, and drying steps were exactly the same as in Example 1, resulting in Chinese herbal powder of the same mass (approximately 1500 g) and particle size.
[0035] 2. Mixing and grinding Same as Example 1.
[0036] 3. Ethanol immersion extraction (low temperature, long-term immersion) Solvent preparation: Prepare approximately 10,500 mL (about 8.4 kg) of 60% vol pure grain liquor. The mass-to-volume ratio of powder to liquor is approximately 1:7.
[0037] Feeding and mixing: Mix 1500 g of Chinese herbal powder with white wine in a glass jar of the same size, following the same procedure as in Example 1.
[0038] Immersion conditions control: Transfer the sealed glass jars to a temperature-controlled refrigerator or incubator, setting the ambient temperature to 16℃±1℃. This low-temperature condition is intended to test the dissolution of components under milder conditions.
[0039] Process management: The soaking period is extended to 25 days. Due to the lower temperature, the molecular diffusion rate is slowed down. Therefore, the stirring frequency is adjusted to once every 120 hours (every 5 days), and the stirring method is the same as before.
[0040] 4. Solid-liquid separation After soaking, the same filtration and pressing methods as in Example 1 were used: initial filtration with a 300-mesh filter cloth, pressing, and fine filtration with a 500-mesh filter cloth. Finally, about 9800 mL of clear medicinal liquid was obtained. Compared with Example 1, the total amount of extract was significantly increased due to the larger amount of solvent and longer soaking time.
[0041] 5. Finished product repackaging and packaging The dispensing, nitrogen filling, sealing, labeling, and packaging steps are exactly the same as in Example 1, with each bottle filled with 50 mL.
[0042] Summary of comparison between Examples 1 and 2: Process differences: Example 2 used a lower soaking temperature (16°C vs 22°C), a longer soaking time (25 days vs 18 days), and a higher alcohol content and liquid-to-solid ratio (60°C, 1:7 vs 53°C, 1:5).
[0043] Expected Results: The process conditions in Example 2 are theoretically more favorable for protecting heat-sensitive components (such as some volatile substances) and compensate for the decrease in extraction rate caused by low temperature by extending the soaking time. Higher ethanol concentrations may improve the extraction efficiency of fat-soluble components (such as some alkaloids and volatile oils). The chemical fingerprint of the final product may differ slightly from that of Example 1, but the core active ingredients are fully extracted.
[0044] Production considerations: Example 2 has a longer process cycle and may consume slightly more energy (if low-temperature control is required), making it suitable for products with higher retention requirements for specific heat-sensitive components. Example 1 achieves a good balance between efficiency and effectiveness, making it more suitable for routine production.
[0045] Comparative Example 1 (shortened soaking time): Using the medicinal formula and pulverization process of Example 1, the medicinal powder and liquor were mixed at a ratio of 1:5 and soaked at the same temperature for 7 days, with other conditions remaining the same.
[0046] Comparative Example 2 (without borneol or menthol): The herbal formula of Example 1 was used, but borneol and peppermint were not added, the total amount of herbs was reduced, other steps were adjusted proportionally, and the soaking process was the same as in Example 1.
[0047] Effect verification and comparative analysis To verify the effectiveness of this invention, the following preliminary analysis was conducted: Determination of key analgesic and anti-inflammatory components: The contents of aconitine alkaloids (calculated as neoaconitine and hypoaconitine), strychnine, and strychnine in each sample were determined by high performance liquid chromatography (HPLC).
[0048] sample Total aconitine alkaloids (μg / mL) Strychnine (μg / mL) Strychnine (μg / mL) Example 1 85.6±3.2 12.3±0.5 8.9±0.4 Example 2 88.1±3.5 (more complete leaching) 11.8±0.6 8.5±0.3 Comparative Example 1 42.1±2.8 5.2±0.4 3.8±0.3 Comparative Example 2 84.2±3.0 12.0±0.5 8.7±0.4 In vitro transdermal absorption assay (Franz diffusion cell): Using isolated mouse skin as a model, the transdermal absorption rates of the samples from Example 1 and Comparative Example 2 were compared. The results showed that the steady-state transdermal absorption rate of aconitine alkaloids in the sample from Example 1 was approximately 1.8 times that of the sample from Comparative Example 2, indicating that borneol and peppermint, as permeation enhancers, could significantly enhance the transdermal absorption of the main active ingredients.
[0049] Animal model analgesia and anti-inflammatory test: A rat model of adjuvant-induced arthritis was used, with topical administration of the drug. Evaluation indicators included paw swelling, pain threshold (hot plate test, pressure analgesia test), and levels of joint inflammatory factors (such as IL-1β and TNF-α).
[0050] Group Foot swelling inhibition rate (%) Pain threshold improvement rate (%) IL-1β reduction rate in synovial fluid (%) Example 1 Group 68.5* 75.2* 60.3* Comparative Example 1 35.2 40.1 32.8 Comparative Example 2 55.6 58.7 52.1 Model control group - - - * indicates that compared with the model control group, P<0.01; compared with comparative examples 1 and 2, the effect of example 1 is significantly better.
[0051] The first embodiment of the present invention is most effective in inhibiting arthritis swelling, increasing the pain threshold, and reducing inflammatory factors.
[0052] Skin irritation test: Single and multiple administration tests on intact and broken skin of rabbits showed that the product of Example 1 had mild and transient irritation to intact skin, which could be reversed upon discontinuation of the drug; and moderate irritation to broken skin, suggesting that this product should be used on intact skin and should be avoided on broken skin, which is consistent with expectations.
[0053] Stability test: The finished product of Example 1 was placed under accelerated conditions of 40℃±2℃ and 75%±5% relative humidity for 6 months and tested regularly. The results showed that there were no significant changes in the appearance, clarity, ethanol content and content of the main active ingredients of the drug solution, and the microbial limit met the requirements, indicating that the formulation had good stability.
[0054] This invention, through specific combinations of medicinal materials (including toxic medicinal materials that have been processed to reduce toxicity and potent blood-activating and meridian-clearing medicinal materials), combined with the core processes of "long-term constant-temperature ethanol cold soaking" and "addition of penetration-enhancing ingredients (borneol, peppermint)," produces a topical Chinese medicine liquid that is significantly superior to the comparative process of shortening the soaking time or not adding penetration enhancers in terms of the content of key active ingredients, transdermal absorption efficiency, and analgesic and anti-inflammatory effects in animal models. This preparation method is scientific, stable, and controllable, and can produce topical preparations for treating synovitis and bone and joint pain with uniform quality, definite efficacy, and relative safety.
[0055] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.
Claims
1. A method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain, characterized in that, Includes the following steps: (1) Raw material pretreatment: Take eighteen kinds of Chinese medicinal materials, including black snake, prepared aconite, prepared aconite root, angelica pubescens, prepared pinellia, eucommia bark, achyranthes root, salvia miltiorrhiza, safflower, earthworm, centipede, horseweed, lycopodium clavatum, clematis chinensis, prepared strychnos nux-vomica, roasted rhubarb, borneol, and mint. Mix them, wash and dry them. (2) Pulverization: Pulverize the Chinese medicinal materials mixture after drying in step (1) and pass it through a 60-100 mesh sieve to obtain Chinese medicinal powder; (3) Ethanol soaking: The Chinese herbal powder is mixed with baijiu with an alcohol content of 50-65 degrees and placed in a sealed container. It is soaked at 10-30℃ for 12-25 days, and stirred regularly during the period to obtain raw medicinal wine containing dregs; wherein, the mass-volume ratio of the Chinese herbal powder to baijiu is 1:4-1:10 (kg / L). (4) Solid-liquid separation: The original medicinal wine is filtered to separate and obtain a clear medicinal liquid; (5) Packaging: The clarified medicinal liquid is filled into a pharmaceutical packaging container and sealed to obtain the finished external Chinese medicine liquid.
2. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (1), the eighteen Chinese medicinal materials, by weight, include: 5-15 parts of black-spotted snake, 3-10 parts of processed aconite root, 3-10 parts of processed aconite root, 10-20 parts of angelica pubescens, 5-12 parts of processed pinellia ternata, 10-20 parts of eucommia ulmoides, 10-20 parts of achyranthes bidentata, 10-25 parts of salvia miltiorrhiza, 5-15 parts of safflower, 5-15 parts of earthworm, 1-5 parts of centipede, 10-25 parts of dwarf sage, 10-25 parts of lycopodium clavatum, 10-25 parts of clematis chinensis, 1-5 parts of processed strychnos nux-vomica, 5-15 parts of roasted rhubarb, 1-5 parts of borneol, and 5-15 parts of peppermint.
3. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (1), the drying is performed at 40-60°C until the moisture content is less than 12%.
4. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (3), the alcohol content of the liquor is 53-62 degrees; the soaking temperature is 18-25℃; and the soaking time is 14-20 days.
5. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 4, characterized in that, In step (3), the soaking process is carried out every 2-5 days, and each time it is stirred for 5-15 minutes.
6. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (3), the mass-to-volume ratio of the Chinese herbal medicine powder to the liquor is 1:5-1:8 (kg / L).
7. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (4), the filtration is carried out using 80-200 mesh filter cloth, filter bag or plate and frame filter.
8. The method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (5), the pharmaceutical packaging container is a brown glass bottle, and the filling volume of each bottle is 30-60 mL; preferably, the filling volume of each bottle is 50 mL.
9. A method for preparing a topical traditional Chinese medicine liquid for treating synovitis and joint pain according to claim 1, characterized in that, In step (5), after dispensing, nitrogen is filled into the packaging container to replace the air at the top, and then it is sealed.